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BOLD Mri

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https://www.readbyqxmd.com/read/28725547/spatial-working-memory-in-neurofibromatosis-1-altered-neural-activity-and-functional-connectivity
#1
Amira F A Ibrahim, Caroline A Montojo, Kristen M Haut, Katherine H Karlsgodt, Laura Hansen, Eliza Congdon, Tena Rosser, Robert M Bilder, Alcino J Silva, Carrie E Bearden
BACKGROUND: Neurofibromatosis Type 1 (NF1) is a genetic disorder that disrupts central nervous system development and neuronal function. Cognitively, NF1 is characterized by difficulties with executive control and visuospatial abilities. Little is known about the neural substrates underlying these deficits. The current study utilized Blood-Oxygen-Level-Dependent (BOLD) functional MRI (fMRI) to explore the neural correlates of spatial working memory (WM) deficits in patients with NF1. METHODS: BOLD images were acquired from 23 adults with NF1 (age M = 32...
2017: NeuroImage: Clinical
https://www.readbyqxmd.com/read/28708550/unsupervised-myocardial-segmentation-for-cardiac-bold
#2
Ilkay Oksuz, Anirban Mukhopadhyay, Rohan Dharmakumar, Sotirios A Tsaftaris
A fully automated 2D+time myocardial segmentation framework is proposed for Cardiac Magnetic Resonance (CMR) Blood-Oxygen-Level-Dependent (BOLD) datasets. Ischemia detection with CINE BOLD CMR relies on spatiotemporal patterns in myocardial intensity but these patterns also trouble supervised segmentation methods, the de-facto standard for myocardial segmentation in cine MRI. Segmentation errors severely undermine the accurate extraction of these patterns. In this paper we build a joint motion and appearance method that relies on dictionary learning to find a suitable subspace...
July 12, 2017: IEEE Transactions on Medical Imaging
https://www.readbyqxmd.com/read/28693449/multiparametric-magnetic-resonance-imaging-in-mucosal-primary-head-and-neck-cancer-a-prospective-imaging-biomarker-study
#3
Christopher N Rumley, Mark T Lee, Lois Holloway, Robba Rai, Myo Min, Dion Forstner, Allan Fowler, Gary Liney
BACKGROUND: Radical radiotherapy, with or without concomitant chemotherapy forms the mainstay of organ preservation approaches in mucosal primary head and neck cancer. Despite technical advances in cancer imaging and radiotherapy administration, a significant proportion of patients fail to achieve a complete response to treatment. For those patients who do achieve a complete response, acute and late toxicities remain a cause of morbidity. A critical need therefore exists for imaging biomarkers which are capable of informing patient selection for both treatment intensification and de-escalation strategies...
July 10, 2017: BMC Cancer
https://www.readbyqxmd.com/read/28692137/portable-perfusion-phantom-for-quantitative-dce-mri-of-the-abdomen
#4
Harrison Kim, Mina Mousa, Patrick Schexnailder, Robert Hergenrother, Mark Bolding, Bernard Ntsikoussalabongui, Vinoy Thomas, Desiree E Morgan
PURPOSE: To develop a portable perfusion phantom and validate its utility in quantitative dynamic contrast-enhanced magnetic resonance imaging of the abdomen. METHODS: A portable perfusion phantom yielding a reproducible contrast enhancement curve (CEC) was developed. A phantom package including perfusion and static phantoms were imaged simultaneously with each of three healthy human volunteers in two different 3T MR scanners. Look-up tables correlating reference (known) contrast concentrations with measured ones were created using either the static or perfusion phantom...
July 10, 2017: Medical Physics
https://www.readbyqxmd.com/read/28687521/simultaneous-gcamp6-based-fiber-photometry-and-fmri-in-rats
#5
Zhifeng Liang, Yuncong Ma, Glenn D R Watson, Nanyin Zhang
BACKGROUND: Understanding the relationship between neural and vascular signals is essential for interpretation of functional MRI (fMRI) results with respect to underlying neuronal activity. Simultaneously measuring neural activity using electrophysiology with fMRI has been highly valuable in elucidating the neural basis of the blood oxygenation-level dependent (BOLD) signal. However, this approach is also technically challenging due to the electromagnetic interference that is observed in electrophysiological recordings during MRI scanning...
July 4, 2017: Journal of Neuroscience Methods
https://www.readbyqxmd.com/read/28687517/comparing-test-retest-reliability-of-dynamic-functional-connectivity-methods
#6
Ann S Choe, Mary Beth Nebel, Anita D Barber, Jessica R Cohen, Yuting Xu, James J Pekar, Brian Caffo, Martin A Lindquist
Due to the dynamic, condition-dependent nature of brain activity, interest in estimating rapid functional connectivity (FC) changes that occur during resting-state functional magnetic resonance imaging (rs-fMRI) has recently soared. However, studying dynamic FC is methodologically challenging, due to the low signal-to-noise ratio of the blood oxygen level dependent (BOLD) signal in fMRI and the massive number of data points generated during the analysis. Thus, it is important to establish methods and summary measures that maximize reliability and the utility of dynamic FC to provide insight into brain function...
July 5, 2017: NeuroImage
https://www.readbyqxmd.com/read/28686788/influence-of-physiological-noise-on-accelerated-2d-and-3d-resting-state-functional-mri-data-at-7%C3%A2-t
#7
Olivier Reynaud, João Jorge, Rolf Gruetter, José P Marques, Wietske van der Zwaag
PURPOSE: Physiological noise often dominates the blood-oxygen level-dependent (BOLD) signal fluctuations in high-field functional MRI (fMRI) data. Therefore, to optimize fMRI protocols, it becomes crucial to investigate how physiological signal fluctuations impact various acquisition and reconstruction schemes at different acquisition speeds. In particular, further differences can arise between 2D and 3D fMRI acquisitions due to different encoding strategies, thereby impacting fMRI sensitivity in potentially significant ways...
July 7, 2017: Magnetic Resonance in Medicine: Official Journal of the Society of Magnetic Resonance in Medicine
https://www.readbyqxmd.com/read/28686073/effect-of-hypoxia-on-bold-fmri-response-and-total-cerebral-blood-flow-in-migraine-with-aura-patients
#8
Nanna Arngrim, Anders Hougaard, Henrik W Schytz, Mark B Vestergaard, Josefine Britze, Faisal Mohammad Amin, Karsten S Olsen, Henrik Bw Larsson, Jes Olesen, Messoud Ashina
Experimentally induced hypoxia triggers migraine and aura attacks in patients suffering from migraine with aura (MA). We investigated the blood oxygenation level-dependent (BOLD) signal response to visual stimulation during hypoxia in MA patients and healthy volunteers. In a randomized double-blind crossover study design, 15 MA patients were allocated to 180 min of normobaric poikilocapnic hypoxia (capillary oxygen saturation 70-75%) or sham (normoxia) on two separate days and 14 healthy volunteers were exposed to hypoxia...
January 1, 2017: Journal of Cerebral Blood Flow and Metabolism
https://www.readbyqxmd.com/read/28684333/improving-temporal-resolution-in-fmri-using-a-3d-spiral-acquisition-and-low-rank-plus-sparse-l-s-reconstruction
#9
Andrii Y Petrov, Michael Herbst, V Andrew Stenger
Rapid whole-brain dynamic Magnetic Resonance Imaging (MRI) is of particular interest in Blood Oxygen Level Dependent (BOLD) functional MRI (fMRI). Faster acquisitions with higher temporal sampling of the BOLD time-course provide several advantages including increased sensitivity in detecting functional activation, the possibility of filtering out physiological noise for improving temporal SNR, and freezing out head motion. Generally, faster acquisitions require undersampling of the data which results in aliasing artifacts in the object domain...
July 4, 2017: NeuroImage
https://www.readbyqxmd.com/read/28678737/functional-brain-mri-in-patients-complaining-of-electrohypersensitivity-after-long-term-exposure-to-electromagnetic-fields
#10
Gunnar Heuser, Sylvia A Heuser
INTRODUCTION: Ten adult patients with electromagnetic hypersensitivity underwent functional magnetic resonance imaging (fMRI) brain scans. All scans were abnormal with abnormalities which were consistent and similar. It is proposed that fMRI brain scans be used as a diagnostic aid for determining whether or not a patient has electromagnetic hypersensitivity. Over the years we have seen an increasing number of patients who had developed multi system complaints after long term repeated exposure to electromagnetic fields (EMFs)...
July 5, 2017: Reviews on Environmental Health
https://www.readbyqxmd.com/read/28676738/the-multiple-correspondence-analysis-method-and-brain-functional-connectivity-its-application-to-the-study-of-the-non-linear-relationships-of-motor-cortex-and-basal-ganglia
#11
Clara Rodriguez-Sabate, Ingrid Morales, Alberto Sanchez, Manuel Rodriguez
The complexity of basal ganglia (BG) interactions is often condensed into simple models mainly based on animal data and that present BG in closed-loop cortico-subcortical circuits of excitatory/inhibitory pathways which analyze the incoming cortical data and return the processed information to the cortex. This study was aimed at identifying functional relationships in the BG motor-loop of 24 healthy-subjects who provided written, informed consent and whose BOLD-activity was recorded by MRI methods. The analysis of the functional interaction between these centers by correlation techniques and multiple linear regression showed non-linear relationships which cannot be suitably addressed with these methods...
2017: Frontiers in Neuroscience
https://www.readbyqxmd.com/read/28674515/investigating-the-blood-oxygenation-level-dependent-functional-mri-response-to-a-verbal-fluency-task-in-early-stroke-before-and-after-hemodynamic-scaling
#12
Veena A Nair, Ryan V Raut, Vivek Prabhakaran
BACKGROUND AND OBJECTIVE: Blood oxygenation level-dependent (BOLD) functional MRI (fMRI) has been extensively used as a marker of brain dysfunction and subsequent recovery following stroke. However, growing evidence suggests that straightforward interpretation of BOLD fMRI changes with aging and disease is challenging. In this study, we investigated the effect of calibrating task fMRI data by applying a hemodynamic calibration method using the resting-state fluctuation amplitude (RSFA)...
2017: Frontiers in Neurology
https://www.readbyqxmd.com/read/28666879/correction-of-metal-induced-susceptibility-artifacts-for-functional-mri-during-deep-brain-stimulation
#13
Myung-Ho In, Shinho Cho, Yunhong Shu, Hoon-Ki Min, Matt A Bernstein, Oliver Speck, Kendall H Lee, Hang Joon Jo
Functional magnetic resonance imaging (fMRI) is an emerging tool for investigating brain activation associated with, or modulated by, deep brain stimulation (DBS). However, DBS-fMRI generally suffers from severe susceptibility to artifacts in regions near the metallic stimulation electrodes, as well as near tissue/air boundaries of the brain. These result in strong intensity and geometric distortions along the phase-encoding (PE) (i.e., blipped) direction in gradient-echo echo-planar imaging (GE-EPI). Distortion presents a major challenge to conducting reliable data analysis and in interpreting the findings...
June 27, 2017: NeuroImage
https://www.readbyqxmd.com/read/28660330/quantitative-mri-of-kidneys-in-renal-disease
#14
Timothy L Kline, Marie E Edwards, Ishan Garg, Maria V Irazabal, Panagiotis Korfiatis, Peter C Harris, Bernard F King, Vicente E Torres, Sudhakar K Venkatesh, Bradley J Erickson
PURPOSE: To evaluate the reproducibility and utility of quantitative magnetic resonance imaging (MRI) sequences for the assessment of kidneys in young adults with normal renal function (eGFR ranged from 90 to 130 mL/min/1.73 m(2)) and patients with early renal disease (autosomal dominant polycystic kidney disease). MATERIALS AND METHODS: This prospective case-control study was performed on ten normal young adults (18-30 years old) and ten age- and sex-matched patients with early renal parenchymal disease (autosomal dominant polycystic kidney disease)...
June 28, 2017: Abdominal Radiology
https://www.readbyqxmd.com/read/28659792/the-serotonin-receptor-6-antagonist-idalopirdine-and-acetylcholinesterase-inhibitor-donepezil-have-synergistic-effects-on-brain-activity-a-functional-mri-study-in-the-awake-rat
#15
Craig F Ferris, Praveen Kulkarni, Jason R Yee, Mark Nedelman, Inge E M de Jong
The 5-HT6 receptor is a promising target for cognitive disorders, in particular for Alzheimer's disease (AD) and other CNS disorders. The high-affinity and selective 5-HT6 receptor antagonist idalopirdine (Lu AE58054) is currently in development for mild-moderate AD as adjunct therapy to acetylcholinesterase inhibitors (AChEIs). We studied the effects of idalopirdine alone and in combination with the AChEI donepezil on brain activity using BOLD (Blood Oxygen Level Dependent) functional magnetic resonance imaging (fMRI) in the awake rat...
2017: Frontiers in Pharmacology
https://www.readbyqxmd.com/read/28655900/oxytocin-administration-suppresses-hypothalamic-activation-in-response-to-visual-food-cues
#16
Agatha A van der Klaauw, Hisham Ziauddeen, Julia M Keogh, Elana Henning, Sekesai Dachi, Paul C Fletcher, I Sadaf Farooqi
The aim of this study was to use functional neuroimaging to investigate whether oxytocin modulates the neural response to visual food cues in brain regions involved in the control of food intake. Twenty-four normal weight volunteers received intranasal oxytocin (24 IU) or placebo in a double-blind, randomized crossover study. Measurements were made forty-five minutes after dosing. On two occasions, functional MRI (fMRI) scans were performed in the fasted state; the blood oxygen level-dependent (BOLD) response to images of high-calorie foods versus low-calorie foods was measured...
June 27, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28655152/faulty-adaptation-to-repeated-face-name-associative-pairs-in-mild-cognitive-impairment-is-predictive-of-cognitive-decline
#17
Sarah M Jurick, Gali H Weissberger, Lindsay R Clark, Christina E Wierenga, Yu-Ling Chang, Dawn M Schiehser, S Duke Han, Amy J Jak, Sheena I Dev, Mark W Bondi
Objective: We examined BOLD (Blood-Oxygen-Level Dependent) activity reduction upon stimuli repetition of face-name pairs in older adults with amnestic (aMCI) and non-amnestic (naMCI) mild cognitive impairment diagnosed using a comprehensive actuarial method, and relationships between activity reduction and behavioral indices. Method: Twenty-nine cognitively healthy older adults (CHs) and 20 with MCI (n = 12 aMCI; n = 8 naMCI) underwent functional MRI event-related imaging, a comprehensive neuropsychological battery, and 1-year follow-up exam...
June 26, 2017: Archives of Clinical Neuropsychology: the Official Journal of the National Academy of Neuropsychologists
https://www.readbyqxmd.com/read/28649490/frequency-dependent-changes-in-local-intrinsic-oscillations-in-chronic-primary-insomnia-a-study-of-the-amplitude-of-low-frequency-fluctuations-in-the-resting-state
#18
Fuqing Zhou, Suhua Huang, Ying Zhuang, Lei Gao, Honghan Gong
New neuroimaging techniques have led to significant advancements in our understanding of cerebral mechanisms of primary insomnia. However, the neuronal low-frequency oscillation remains largely uncharacterized in chronic primary insomnia (CPI). In this study, the amplitude of low-frequency fluctuation (ALFF), a data-driven method based on resting-state functional MRI, was used to examine local intrinsic activity in 27 patients with CPI and 27 age-, sex-, and education-matched healthy controls. We examined neural activity in two frequency bands, slow-4 (between 0...
2017: NeuroImage: Clinical
https://www.readbyqxmd.com/read/28634048/activation-volume-vs-bold-signal-change-as-measures-of-fmri-activation-its-impact-on-gaba-fmri-activation-correlation
#19
Pallab K Bhattacharyya, Micheal D Phillips, Lael A Stone, Mark J Lowe
PURPOSE: To explore the relative robustness of functional MRI (fMRI) activation volume and blood oxygen level-dependent (BOLD) signal change as fMRI metric, and to study the effect of relative robustness on the correlation between fMRI activation and cortical gamma amino butyric acid (GABA) in healthy controls and patients with multiple sclerosis (MS). METHODS: fMRI data were acquired from healthy controls and patients with MS, with the subjects peforming self paced bilateral finger tapping in block design...
June 17, 2017: Magnetic Resonance Imaging
https://www.readbyqxmd.com/read/28629975/anatomical-and-functional-properties-of-the-foot-and-leg-representation-in-areas-3b-1-and-2-of-primary-somatosensory-cortex-in-humans-a-7t-fmri-study
#20
Michel Akselrod, Roberto Martuzzi, Andrea Serino, Wietske van der Zwaag, Roger Gassert, Olaf Blanke
Primary somatosensory cortex (S1) processes somatosensory information and is composed of multiple subregions. In particular, tactile information from the skin is encoded in three subregions, namely Brodmann areas (BAs) 3b, 1 and 2, with each area representing a complete map of the contralateral body. Although, much is known about the somatotopic organization of the hand in human S1, less research has been carried out regarding the somatotopic maps of the foot and leg in S1. Moreover, a latero-medial S1 organization along the superior part of the postcentral gyrus has been reported when moving from hip to toes, yet to date there is no study investigating leg/foot maps within the different subregions of S1...
June 16, 2017: NeuroImage
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