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Carotid sinus

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https://www.readbyqxmd.com/read/29333912/the-resting-state-fmri-arterial-signal-predicts-differential-blood-transit-time-through-the-brain
#1
Yunjie Tong, Jinxia Fiona Yao, J Jean Chen, Blaise deB Frederick
Previous studies have found that aperiodic, systemic low-frequency oscillations (sLFOs) are present in blood-oxygen-level-dependent (BOLD) data. These signals are in the same low frequency band as the "resting state" signal; however, they are distinct signals which represent non-neuronal, physiological oscillations. The same sLFOs are found in the periphery (i.e. finger tips) as changes in oxy/deoxy-hemoglobin concentration using concurrent near-infrared spectroscopy. Together, this evidence points toward an extra-cerebral origin of these sLFOs...
January 1, 2018: Journal of Cerebral Blood Flow and Metabolism
https://www.readbyqxmd.com/read/29332196/bioelectronic-modulation-of-carotid-sinus-nerve-activity-in-the-rat-a-potential-therapeutic-approach-for-type-2-diabetes
#2
Joana F Sacramento, Daniel J Chew, Bernardete F Melo, Matteo Donegá, Wesley Dopson, Maria P Guarino, Alison Robinson, Jesus Prieto-Lloret, Sonal Patel, Bradley J Holinski, Nishan Ramnarain, Victor Pikov, Kristoffer Famm, Silvia V Conde
AIMS/HYPOTHESIS: A new class of treatments termed bioelectronic medicines are now emerging that aim to target individual nerve fibres or specific brain circuits in pathological conditions to repair lost function and reinstate a healthy balance. Carotid sinus nerve (CSN) denervation has been shown to improve glucose homeostasis in insulin-resistant and glucose-intolerant rats; however, these positive effects from surgery appear to diminish over time and are heavily caveated by the severe adverse effects associated with permanent loss of chemosensory function...
January 14, 2018: Diabetologia
https://www.readbyqxmd.com/read/29330795/measurement-of-sensory-nerve-activity-from-the-carotid-body
#3
Ying-Jie Peng, Nanduri R Prabhakar
Carotid bodies are sensory organs for monitoring chemical composition of the arterial blood, especially the O2 levels. Carotid bodies are located bilaterally at the bifurcation of the common carotid artery. Hypoxia increases sensory nerve activity of the carotid body, which is transmitted to the brainstem neurons triggering reflex stimulation of breathing and blood pressure. Measurement of action potentials from the carotid sinus nerve is a widely used approach for understanding the mechanisms of hypoxic sensing by the carotid body...
2018: Methods in Molecular Biology
https://www.readbyqxmd.com/read/29329321/impact-of-lipopolysaccharide-induced-acute-inflammation-on-baroreflex-controlled-sympathetic-arterial-pressure-regulation
#4
Takeshi Tohyama, Keita Saku, Toru Kawada, Takuya Kishi, Keimei Yoshida, Takuya Nishikawa, Hiroshi Mannoji, Kazuhiro Kamada, Kenji Sunagawa, Hiroyuki Tsutsui
BACKGROUND: Lipopolysaccharide (LPS) induces acute inflammation, activates sympathetic nerve activity (SNA) and alters hemodynamics. Since the arterial baroreflex is a negative feedback system to stabilize arterial pressure (AP), examining the arterial baroreflex function is a prerequisite to understanding complex hemodynamics under LPS challenge. We investigated the impact of LPS-induced acute inflammation on SNA and AP regulation by performing baroreflex open-loop analysis. METHODS: Ten anesthetized Sprague-Dawley rats were used...
2018: PloS One
https://www.readbyqxmd.com/read/29326418/a-case-of-right-sided-direct-carotid-cavernous-fistula-a-diagnostic-challenge
#5
Htun Latt, Kyaw Kyaw, Htwe Htwe Yin, Deepak Kapoor, Sammy San Myint Aung, Raheel Islam
BACKGROUND Carotid cavernous fistulas (CCFs) are rare potentially sight-threatening abnormal connections between carotid artery and cavernous sinus. CASE REPORT We report a case of CCF in an 83-year-old female, who presented with swollen and painful right eye. The patient was initially treated with empiric antibiotics for suspected peri-orbital cellulitis, as noted clinically and in computed tomography (CT) orbits. However, lack of clinical improvement, physical finding of orbital bruit/thrill, and enlarged superior ophthalmic vein in magnetic resonance (MR) orbits suggest alternate diagnoses...
January 12, 2018: American Journal of Case Reports
https://www.readbyqxmd.com/read/29313987/variable-role-of-carotid-bodies-in-cardiovascular-responses-to-exercise-hypoxia-and-hypercapnia-in-spontaneously-hypertensive-rats
#6
Wioletta Pijacka, Pedro L Katayama, Helio C Salgado, Gisele S Lincevicius, Ruy R Campos, Fiona D McBryde, Julian F R Paton
The carotid body has recently emerged as a promising therapeutic target for treating cardiovascular disease, however the potential impact of carotid bodies removal on the dynamic cardiovascular responses to acute stressors such as exercise, hypoxia and hypercapnia in hypertension is an important safety consideration that has not been studied. We first validated a novel surgical approach to selectively resect the carotid bodies bilaterally (CBR) sparing the carotid sinus baroreflex. Second, we evaluated the impact of CBR on the cardiovascular responses to exercise, hypoxia and hypercapnia in the conscious, chronically instrumented spontaneously hypertensive (SH) rats...
January 5, 2018: Journal of Physiology
https://www.readbyqxmd.com/read/29301059/objective-validation-of-perfusion-based-human-cadaveric-simulation-training-model-for-management-of-internal-carotid-artery-injury-in-endoscopic-endonasal-sinus-and-skull-base-surgery
#7
Jasper Shen, Kevin Hur, Zhipeng Zhang, Michael Minneti, Martin Pham, Bozena Wrobel, Gabriel Zada
BACKGROUND: The emergence of minimally invasive endoscopic endonasal skull base surgery has necessitated reproducible and realistic simulators of rare vascular injuries. OBJECTIVE: To assess the face and content validity of an innovative perfusion-based cadaveric model developed to simulate internal carotid artery (ICA) injury during endoscopic surgery. METHODS: Otolaryngology and neurosurgery trainees attempted 3 consecutive trials of endoscopic control of a parasellar ICA injury, with standardized technical feedback...
December 29, 2017: Operative Neurosurgery (Hagerstown, Md.)
https://www.readbyqxmd.com/read/29288968/value-of-external-carotid-artery-resistive-index-for-diagnosis-of-cavernous-sinus-dural-arteriovenous-fistula-and-determination-of-malignant-type
#8
Chai Kobkitsuksakul, Wasawat Soratcha, Ekachat Chanthanaphak
PURPOSE: Cavernous sinus dural arteriovenous fistula (CSDAVF) causes hemodynamic disturbance in the arteries, which is detected by carotid Doppler sonography (CDS). The objective of the study was designed for validation of CDS in the diagnosis of CSDAVF. MATERIAL AND METHODS: 42 CSDAVF patients confirmed by angiography were enrolled. All patients were performed CDS before angiography. Evaluations of CDS parameters were compared with control subjects. RESULTS: The ECA resistive index (RI) shows the best performance...
November 16, 2017: Clinical Imaging
https://www.readbyqxmd.com/read/29288887/modeling-the-control-of-the-central-nervous-system-over-the-cardiovascular-system-using-support-vector-machines
#9
José Díaz, Jesús Acosta, Rafael González, Juan Cota, Ernesto Sifuentes, Àngela Nebot
The control of the central nervous system (CNS) over the cardiovascular system (CS) has been modeled using different techniques, such as fuzzy inductive reasoning, genetic fuzzy systems, neural networks, and nonlinear autoregressive techniques; the results obtained so far have been significant, but not solid enough to describe the control response of the CNS over the CS. In this research, support vector machines (SVMs) are used to predict the response of a branch of the CNS, specifically, the one that controls an important part of the cardiovascular system...
December 15, 2017: Computers in Biology and Medicine
https://www.readbyqxmd.com/read/29260615/preliminary-evidence-for-cerebral-capillary-shunting-in-adults-with-sickle-cell-anemia
#10
Meher R Juttukonda, Manus J Donahue, Larry T Davis, Melissa C Gindville, Chelsea A Lee, Niral J Patel, Adetola A Kassim, Sumit Pruthi, Jeroen Hendrikse, Lori C Jordan
Elevated flow velocities in adults with sickle cell anemia (SCA) may cause rapid erythrocyte transit through capillaries. This phenomenon could present as dural venous sinus hyperintensity on arterial spin labeling (ASL)-MRI and could be indicative of capillary shunting. Here, the prevalence of ASL venous hyperintensities and association with relevant physiology in adults with SCA was investigated. SCA ( n = 46) and age-matched control ( n = 16) volunteers were recruited for 3.0 T MRI. Pseudo-continuous ASL-MRI was acquired for cerebral blood flow (CBF) calculation and venous hyperintensity determination; venous signal intensity and a categorical venous score (three raters; 0 = no hyperintensity, 1 = focal hyperintensity, and 2 = diffuse hyperintensity) were recorded...
January 1, 2017: Journal of Cerebral Blood Flow and Metabolism
https://www.readbyqxmd.com/read/29260105/invasive-streptococcus-viridans-sphenoethmoiditis-leading-to-an-orbital-apex-syndrome
#11
Lance Bodily, Jenny Yu, Dante Sorrentino, Barton Branstetter
Purpose: Orbital apex syndrome due to spread of infectious sinusitis is a serious disease, often with an insidious presentation with few ophthalmic signs and symptoms. Failure to recognize and treat infectious orbital apex syndrome early portends a grave prognosis, including profound, permanent visual loss and potentially death. Herein we describe a representative case and discuss the relevant aspects of prompt diagnosis and treatment. Observations: An unusual case of infectious orbital apex syndrome due to contiguous spread of Streptococcus viridans sphenoethmoiditis in a hospitalized, immunosuppressed patient with acute myelogenous leukemia is presented...
December 2017: American Journal of Ophthalmology Case Reports
https://www.readbyqxmd.com/read/29251712/prediction-of-traumatic-carotid-cavernous-sinus-fistula-via-non-contrast-ct-by-fracture-pattern-and-abnormality-of-venous-system
#12
Shih-Hsuan Mao, Tzu-Chin Lin, Chih-Hao Chen, Pang-Yun Chou, Shang-Yu Wang, Yon-Cheong Wong, Chien-Tzung Chen
BACKGROUND: Traumatic carotid-cavernous sinus fistula (tCCF) is infrequent but with high morbidity if delayed diagnosed or managed. Due to the lack of screening criteria and requirement of advanced and invasive radiological examinations, diagnosis is often delayed or underdiagnosed. METHODS: A matched case-control study with univariate and multivariate analysis was conducted to predict tCCFs. Forty-six patients diagnosed with tCCFs were included and matched with 138 patients of craniofacial trauma without tCCF as control at a ratio of 1:3...
December 14, 2017: Journal of Trauma and Acute Care Surgery
https://www.readbyqxmd.com/read/29227793/bilateral-traumatic-caroticocavernous-fistulas-a-case-report-and-review-of-the-literature
#13
Lorna Leandro, Giovanni Dolci, Satheesh Prabhu, Rufus Corkill
A traumatic caroticocavernous fistula (CCF) is an acquired, abnormal communication between the internal carotid artery and the cavernous sinus, secondary to trauma. This rare condition can initially be misdiagnosed, because its presentation shares features common to those of facial trauma, which can result in serious complications. We describe a case of bilateral CCF in an adult patient after a road traffic accident.
November 23, 2017: Journal of Oral and Maxillofacial Surgery
https://www.readbyqxmd.com/read/29218256/intracranial-anatomical-triangles-a-comprehensive-illustrated-review
#14
REVIEW
Doniel Drazin, Joy Mh Wang, Fernando Alonso, Daxa M Patel, Andre Granger, Mohammadali M Shoja, Marios Loukas, Rod J Oskouian, R Shane Tubbs
There are multiple anatomical triangles of the skull base. However, to our knowledge, there has been no comprehensive review of these geometric landmarks. To allow for a safe and consistent approach to lesions of the skull base such as those near the internal carotid artery, internal acoustic meatus, and cavernous sinus, a comprehensive review of the variations with illustrations is required. This article provides an overview of the anatomical borders, dimensions, and surgical implications as well as illustrations of the major skull base triangles...
October 4, 2017: Curēus
https://www.readbyqxmd.com/read/29211048/imaging-characteristics-of-malignant-sinonasal-tumors
#15
REVIEW
Masaya Kawaguchi, Hiroki Kato, Hiroyuki Tomita, Keisuke Mizuta, Mitsuhiro Aoki, Akira Hara, Masayuki Matsuo
Malignancies of the nasal cavity and paranasal sinuses account for 1% of all malignancies and 3% of malignancies of the upper aerodigestive tract. In the sinonasal tract, nearly half of all malignancies arise in the nasal cavity, whereas most of the remaining malignancies arise in the maxillary or ethmoid sinus. Squamous cell carcinoma is the most common histological subtype of malignant tumors occurring in this area, followed by other epithelial carcinomas, lymphomas, and malignant soft tissue tumors. Although many of these tumors present with nonspecific symptoms, each tumor exhibits characteristic imaging features...
December 6, 2017: Journal of Clinical Medicine
https://www.readbyqxmd.com/read/29210860/aortic-dilatation-in-marfan-syndrome-role-of-arterial-stiffness-and-fibrillin-1-variants
#16
Paolo Salvi, Andrea Grillo, Susan Marelli, Lan Gao, Lucia Salvi, Maurizio Viecca, Anna Maria Di Blasio, Renzo Carretta, Alessandro Pini, Gianfranco Parati
OBJECTIVE: Marfan syndrome (MFS) is an autosomal dominant genetic disorder characterized by aortic root dilation and dissection and an abnormal fibrillin-1 synthesis. In this observational study, we evaluated aortic stiffness in MFS and its association with ascending aorta diameters and fibrillin-1 genotype. METHODS: A total of 116 Marfan adult patients without history of cardiovascular surgery, and 144 age, sex, blood pressure and heart rate matched controls were enrolled...
January 2018: Journal of Hypertension
https://www.readbyqxmd.com/read/29204306/facial-palsy-after-embolization-of-dural-arteriovenous-fistula-a-case-report-and-literature-review
#17
Luana Antunes Maranha Gatto, Fernando Saurin, Gelson Luis Koppe, Zeferino Demartini
Background: Dural arteriovenous fistulas (DAVF) are unusual intracranial vascular malformations consisting of anomalous connections between meningeal arteries and dural sinuses or the veins that pass through them. They have variable clinical presentation and prognosis, which depend on their location and venous hemodynamics. Treatment is based on the closure of the abnormal connections, which is usually conducted via arterial and/or transvenous endovascular techniques. Case Description: We present a male patient who complained of headaches and left-sided pulsatile tinnitus due to DAVF from the external carotid artery branches draining directly into the ipsilateral sigmoid sinus...
2017: Surgical Neurology International
https://www.readbyqxmd.com/read/29201224/expression-of-nf-e2-related-factor-2-in-a-rat-dural-arteriovenous-fistula-model
#18
Limin Dou, Wenhua Yu
Intracranial dural arteriovenous fistulas (DAVFs) are complex intracranial vascular malformations that may lead to hemorrhage. Although the precise mechanisms by which DAVFs occur remain unknown, dural angiogenesis may be a vital factor in its pathogenesis. Nuclear factor erythroid 2-related factor 2 (Nrf2) significantly influences angiogenesis; however, the association between DAVF and Nrf2 remains unclear. Therefore, the present study investigated whether DAVF alters the expression of Nrf2 in an experimental animal model of DAVF...
November 2017: Experimental and Therapeutic Medicine
https://www.readbyqxmd.com/read/29200154/rhinocerebral-mucormycosis-with-temporal-artery-thrombosis-in-an-adolescent-following-hla-haploidentical-stem-cell-transplantation
#19
Yuta Kawahara, Shoya Wada, Hitomi Nijima, Tomomi Hayase, Rieko Furukawa, Kentaro Ashizawa, Akira Morimoto
Rhinocerebral mucormycosis (RCM) can lead to internal carotid artery thrombosis. Here, we report the first case of RCM with temporal artery thrombosis following HLA-haploidentical stem cell transplantation in an adolescent presenting with low-grade fever, right mandibular pain, and right jaw claudication. This case suggests that RCM can cause temporal artery thrombosis and should be considered as a differential diagnosis in severely immunocompromised patients with maxillary sinusitis presenting with jaw claudication...
December 1, 2017: Journal of Pediatric Hematology/oncology
https://www.readbyqxmd.com/read/29189199/intrasellar-cavernous-hemangioma-presenting-as-pituitary-adenoma-a-report-of-two-cases-and-review-of-the-literature
#20
Sumit Das, Lee-Cyn Ang, David Ramsay
Cavernous hemangioma in the sellar region is quite rare with only a handful of cases being reported in the English literature. Its clinical manifestations and imaging characteristics can mimic those of a pituitary adenoma. We report two cases of recurrent sellar lesions, both of which were clinically suspected of being pituitary adenomas but histologically confirmed as cavernous hemangiomas. The first case is of a 67-year-old female whose initial resection was diagnosed as "venous angioma". Neuroimaging performed 27 years later demonstrated significant growth of the lesion involving the right cavernous sinus and encasing the right internal carotid artery...
November 30, 2017: Clinical Neuropathology
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