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https://www.readbyqxmd.com/read/28932106/out-of-pocket-costs-and-adherence-to-antihypertensive-agents-among-older-adults-covered-by-the-public-drug-insurance-plan-in-quebec
#1
Raymond Milan, Helen-Maria Vasiliadis, Samantha Gontijo Guerra, Djamal Berbiche
OBJECTIVE: To evaluate the effect of patient out-of-pocket costs on adherence to antihypertensive agents (AHA) in community-dwelling older adults covered by the public drug insurance plan in Quebec. METHODS: This is a secondary analysis of data from the "Étude sur la santé des aînés" study (2005-2008) on community-dwelling older adults in Quebec aged 65 years and older (N=2,811). The final sample included 881 participants diagnosed with arterial hypertension and treated with AHA...
2017: Patient Preference and Adherence
https://www.readbyqxmd.com/read/28930625/ectopic-adrenal-tissue-associated-with-borderline-mucinous-cystadenoma-of-ovary-a-case-report-with-review-of-the-literature
#2
Kah Teik Chew, Muhammad Azrai Abu, Yulianty Arifuddin, Nor Azlin Mohamed Ismail, Noor Ain Mohd Nasir, Fazarina Mohammed, Abdul Ghani Nur Azurah
Ectopic adrenal tissue in the ovary is a rare entity. We reported a case of ectopic adrenal tissue in borderline mucinous cystadenoma of the left ovary. A 22 year-old student presented with progressive abdomen distension associated with discomfort for 3 months. Imaging investigation was suggestive of mucinous left ovarian cyst. Left salpingo-oophorectomy was performed and the histopathology revealed borderline mucinous cystadenoma with an incidental finding of ectopic adrenal tissue. This is an interesting case because of its rarity and potential risk of neoplasm changes...
September 20, 2017: Hormone Molecular Biology and Clinical Investigation
https://www.readbyqxmd.com/read/28928344/knowledge-of-scientific-misconduct-in-publication-among-medical-students
#3
Syed Muhammad Mubeen, Rabia Ghayas, Syed Hasan Adil Rizvi, Sohaib Ahmed Khan
BACKGROUND: Publication is a central element in research dissemination and scientific misconduct in publication is relatively ignored in biomedical research. This study is to assess the knowledge of scientific misconduct in publication among private and public sector medical students. METHODS: A questionnaire-based cross-sectional study was carried in four (two public and two private) medical colleges of Karachi in 2015. After ethical approval, data were collected through convenient sampling and analyzed in SPSS 16...
May 2017: Education for Health: Change in Training & Practice
https://www.readbyqxmd.com/read/28924273/evaluation-of-random-plasma-glucose-for-assessment-of-glycaemic-control-in-type-2-diabetes-mellitus
#4
Qurratul Ain, Atif Latif, Syed Raza Jaffar, Aamir Ijaz
OBJECTIVE: To evaluate the accuracy of random plasma glucose in outpatients with type 2 diabetes mellitus for assessing glycaemic control. METHODS: This comparative, cross-sectional study was conducted at the chemical pathology department of PNS Shifa Hospital, Karachi, from August 2015 to March 2016, and comprised data of subjects with type 2 diabetes mellitus who reported for evaluation of glycaemic control in non-fasting state. All blood samples were analysed for random plasma glucose and glycated haemoglobin...
September 2017: JPMA. the Journal of the Pakistan Medical Association
https://www.readbyqxmd.com/read/28923322/cycloartane-type-triterpene-glycosides-anopanins-a-c-with-monoacyldigalactosylglycerols-from-anodendron-paniculatum
#5
Viet Duc Ho, Thi Nhu Hanh Hoang, Quoc Hung Vo, Van Kiem Phan, Tuan Anh Le, Viet Ty Pham, Minh Hien Nguyen, Takeshi Kodama, Takuya Ito, Hiroyuki Morita, Ain Raal, Thi Hoai Nguyen
Three cycloartane-type triterpene glycosides (anopanins A-C), together with three known monoacyldigalactosylglycerols gingerglycolipids A-C and (2S)-1-O-palmitoyl-3-O-[α-d-galactopyranosyl-(1→6)-β-d-galactopyranosyl]-sn-glycerol, were isolated from the aerial parts of Anodendron paniculatum collected in Viet Nam. The chemical structures of the present compounds were elucidated by means of 1D and 2D NMR and HRESIMS spectroscopy, and by comparing to the reported data in the literature. These compounds did not show significant growth inhibitory activities (IC50 > 100 μg/mL) against the tested cancer cell lines LU-1 (lung adenocarcinoma), KB (epidermoid carcinoma), Hep-G2 (hepatoma cancer), MKN-7 (stomach cancer), and SW-480 (colon adenocarcinoma)...
September 15, 2017: Phytochemistry
https://www.readbyqxmd.com/read/28916743/comparative-analysis-reveals-regulatory-motifs-at-the-ains-ainr-pheromone-signaling-locus-of-vibrio-fischeri
#6
John H Kimbrough, Eric V Stabb
Vibrio fischeri uses the AinS/AinR pheromone-signaling system to control bioluminescence and other symbiotic colonization factors. The Ain system is thought to initiate cell-cell signaling at moderate cell densities and to prime the LuxI/LuxR signaling system. Here we compared and analyzed the ain locus from two V. fischeri strains and a Vibrio salmonicida strain to explore ain regulation. The ainS and ainR genes were predicted to constitute an operon, which we corroborated using RT-PCR. Comparisons between strains revealed a stark area of conservation across the ainS-ainR junction, including a large inverted repeat in ainR...
September 15, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28905059/fe2o3-a-cost-effective-and-environmentally-friendly-catalyst-for-the-generation-of-nh3-a-future-fuel-using-a-new-al2o3-looping-based-technology
#7
Ye Wu, Guodong Jiang, Hongbo Zhang, Zhao Sun, Yuan Gao, Xiaoping Chen, Huazhang Liu, Hanjing Tian, Qinghua Lai, Maohong Fan, Dong Liu
Fe2O3 is found to be a cost-effective and environmentally friendly catalyst for chemical looping generation of NH3 - a future fuel. The optimal Fe2O3 loading on nitrogen carriers, AIN, is 5 wt%. Fe2O3 can reduce the activation energy of the N-desorption step of AIN by 100 kJ mol(-1) or ∼30%.
September 14, 2017: Chemical Communications: Chem Comm
https://www.readbyqxmd.com/read/28891598/prevalence-of-human-papillomavirus-in-benign-and-malignant-laryngeal-lesions-in-egyptian-patients-cross-sectional-study
#8
Peter Milad, Hany Kassamy, Anas Askoura, Soha Auelela, Ramy Salem, Dina Ragab
OBJECTIVE: To assess the prevalence of HPV in benign and malignant laryngeal lesions among Egyptian patients. DESIGN: Observational analytical cross-sectional study. SETTING: Ain Shams University hospital, Otorhinolaryngology department. PARTICIPANTS: Formalin-fixed paraffin-embedded specimens of 126 patients (70 benign laryngeal lesions and 56 squamous cell carcinoma lesions) were assessed for the presence of HPV DNA using MY09/11 PCR-based DNA detection...
September 11, 2017: Clinical Otolaryngology
https://www.readbyqxmd.com/read/28891270/genetic-diversity-and-pathogenicity-of-fusarium-species-associated-with-fruit-rot-disease-in-banana-across-peninsular-malaysia
#9
Nur Baiti Abd Murad, Nik Mohd Izham Nik Mohamed, Shamarina Shohaimi, Nur Ain Izzati Mohd Zainudin
AIMS: The aims of this study are to identify the Fusarium isolates based on translation elongation factor (tef) 1α sequence, to determine the genetic diversity among isolates and species using selected microsatellite markers, and to examine the pathogenicity of Fusarium isolates causing fruit rot disease of banana. METHODS AND RESULTS: One-hundred thirteen microfungi isolates were obtained from fruit rot infected banana in Peninsular Malaysia. However, this study was focused on the dominant number of the discovered microfungi that belongs to the genus Fusarium...
September 11, 2017: Journal of Applied Microbiology
https://www.readbyqxmd.com/read/28890397/regulated-expression-of-the-tp%C3%AE-isoform-of-the-human-t-prostanoid-receptor-by-the-tumour-suppressors-foxp1-and-nkx3-1-implications-for-the-role-of-thromboxane-in-prostate-cancer
#10
Aine G O'Sullivan, Sarah B Eivers, Eamon P Mulvaney, B Therese Kinsella
The prostanoid thromboxane (TX)A2 signals through the TPα and TPβ isoforms of T Prostanoid receptor (TP) that are transcriptionally regulated by distinct promoters termed Prm1 and Prm3, respectively, within the TBXA2R gene. We recently demonstrated that expression of TPα and TPβ is increased in PCa, differentially correlating with Gleason grade and with altered CpG methylation of the individual Prm1/Prm3 regions within the TBXA2R. The current study sought to localise the sites of CpG methylation within Prm1 and Prm3, and to identify the main transcription factors regulating TPβ expression through Prm3 in the prostate adenocarcinoma PC-3 and LNCaP cell lines...
September 8, 2017: Biochimica et Biophysica Acta
https://www.readbyqxmd.com/read/28889156/oxidative-damage-and-associated-inflammatory-risk-factors-in-obese-emirati-women-body-mass-index-versus-waist-circumference
#11
Salah Gariballa, Juma Alkaabi, Javed Yasin, Awad Al Essa
OBJECTIVES: To establish whether body mass index (BMI) or waist circumference (WC) is a better predictor of cardio metabolic risk factors that are associated with increased visceral fat among obese women from the United Arab Emirates (UAE). METHODS: In this  cross-sectional study, 333 obese subjects visiting community health centers in Al Ain city, UAE, were recruited between 2012 and 2015. After a written consent subjects had anthropometric, clinical and biochemical measurements...
September 2017: Saudi Medical Journal
https://www.readbyqxmd.com/read/28888269/depression-is-associated-with-recurrent-chest-pain-with-or-without-coronary-artery-disease-a-prospective-cohort-study-in-the-emergency-department
#12
Yeunjung Kim, Morgan Soffler, Summer Paradise, Qurat-Ul-Ain Jelani, James Dziura, Rajita Sinha, Basmah Safdar
BACKGROUND: Only a small fraction of acute chest pain in the emergency department (ED) is due to obstructive coronary artery disease (CAD). ED chest pain remains associated with high rates of recidivism, often in the presence of nonobstructive CAD. Psychological states such as depression, anxiety, and elevation of perceived stress may account for this finding. The objective of the study was to determine whether psychological states predict recurrent chest pain (RCP). METHODS: We conducted a prospective cohort study of low- to moderate-cardiac risk ED patients admitted to the Yale Chest Pain Center with acute chest pain...
September 2017: American Heart Journal
https://www.readbyqxmd.com/read/28881579/methylation-of-hpv-and-a-tumor-suppressor-gene-reveals-anal-cancer-and-precursor-lesions
#13
Attila T Lorincz, Mayura Nathan, Caroline Reuter, Rhian Warman, Mohamed A Thaha, Michael Sheaff, Natasa Vasiljevic, Amar Ahmad, Jack Cuzick, Peter Sasieni
We studied DNA methylation patterns of human papillomavirus (HPV) and tumor suppressor gene EPB41L3 in 148 anal and perianal biopsies to determine whether high levels of methylation would be associated with anal intraepithelial neoplasia (AIN). The most prevalent HPV type was HPV16, detected in 54% of the 30 benign biopsies, 33% of the 43 low-grade AIN (lgAIN), 82% of the 59 high grade AIN (hgAIN) and 4 of the 5 anal cancers. A methylation score was developed (0.561*HPV16me+0.439*EPB41L3) which had increasing values with severity of disease: the mean was 8...
August 1, 2017: Oncotarget
https://www.readbyqxmd.com/read/28881106/quantitative-assessment-of-airway-dimensions-in-young-children-with-cystic-fibrosis-lung-disease-using-chest-computed-tomography
#14
Wieying Kuo, Thomas Soffers, Eleni-Rosalina Andrinopoulou, Tim Rosenow, Sarath Ranganathan, Lidija Turkovic, Stephen M Stick, Harm A W M Tiddens
OBJECTIVE: To evaluate lung disease progression using airway and artery (AA) dimensions on chest CT over 2-year interval in young CF patients longitudinally and compare to disease controls cross-sectionally. METHODS: Retrospective analysis of pressure controlled end-inspiratory CTs, 12 routine baseline (CT1 ) and follow up (CT2 ) from AREST CF cohort; 12 disease controls with normal CT. All visible AA-pairs were measured perpendicular to the airway axis. Inner and outer airway diameters and wall (outer-inner radius) thickness were divided by adjacent arteries to compute Ain A-, Aout A-, and AWT A-ratios, respectively...
September 7, 2017: Pediatric Pulmonology
https://www.readbyqxmd.com/read/28871508/a-novel-role-of-a-chemotherapeutic-agent-in-a-rat-model-of-endotoxemia-modulation-of-the-stat-3-signaling-pathway
#15
Omnia S Zaki, Marwa M Safar, Afaf A Ain-Shoka, Laila A Rashed
Sepsis caused by lipopolysaccharide (LPS) is a life-threatening disease accompanied by multiple organ failure. This study investigated the curative effects of imatinib (IMA) against hepatic, renal, and pulmonary responses caused by a single administration of LPS (10 mg/kg, i.p.) in rats. Treatment with IMA (15 mg/kg, i.p.) 30 min after LPS antagonized the LPS-induced boost of liver enzymes (ALT, AST), kidney functions (BUN, sCr) as well as the elevated pulmonary vascular permeability and edema. IMA declined tissue contents of NF-κB, STAT-3, P38-MAPK, TNF-α, IL-1β, and iNOS...
September 4, 2017: Inflammation
https://www.readbyqxmd.com/read/28855418/analyses-of-selenotranscriptomes-and-selenium-concentrations-in-response-to-dietary-selenium-deficiency-and-age-reveal-common-and-distinct-patterns-by-tissue-and-sex-in-telomere-dysfunctional-mice
#16
Lei Cao, Li Zhang, Huawei Zeng, Ryan Ty Wu, Tung-Lung Wu, Wen-Hsing Cheng
Background: The hierarchies of tissue selenium distribution and selenotranscriptomes are thought to critically affect healthspan and longevity.Objective: We determined selenium status and selenotranscriptomes in response to long-term dietary selenium deficiency and age in tissues of male and female mice.Methods: Weanling telomerase RNA component knockout C57BL/6 mice were fed a selenium-deficient (0.03 mg Se/kg) Torula yeast-based AIN-93G diet or a diet supplemented with sodium selenate (0.15 mg Se/kg) until age 18 or 24 mo...
August 30, 2017: Journal of Nutrition
https://www.readbyqxmd.com/read/28835456/systematic-review-of-pharmacological-therapies-for-the-management-of-ischaemic-pain-in-patients-with-non-reconstructable-critical-limb-ischaemia
#17
REVIEW
Áine Ní Laoire, Fliss E M Murtagh
BACKGROUND: Critical limb ischaemia (CLI) is a severe manifestation of peripheral arterial disease, characterised by chronic ischaemic rest pain, ulcers or gangrene. Management of ischaemic pain is challenging in patients with no options for revascularisation and optimal pharmacological therapies have not been established. OBJECTIVES: To identify and evaluate the effectiveness of pharmacological therapies to treat ischaemic pain secondary to non-reconstructable CLI...
August 23, 2017: BMJ Supportive & Palliative Care
https://www.readbyqxmd.com/read/28833244/anti-human-neutrophil-antigen-1a-1b-and-2-antibodies-in-neonates-and-children-with-immune-neutropenias-analyzed-by-extracted-granulocyte-antigen-immunofluorescence-assay
#18
Rie Onodera, Emi Kurita, Kikuyo Taniguchi, Shuhei Karakawa, Satoshi Okada, Hirotaka Kihara, Teruhisa Fujii, Masao Kobayashi
BACKGROUND: Anti-human neutrophil antigen (HNA) antibodies have been implicated in the development of neonatal alloimmune neutropenia (NAN) and autoimmune neutropenia (AIN). There are many conventional assay methods that detect anti-HNA antibodies. However, a method to measure multiple samples and detect several anti-HNA antibodies simultaneously is needed. STUDY DESIGN AND METHODS: We developed a new method, the extracted granulocyte antigen immunofluorescence assay (EGIFA), to analyze anti-HNA-1a, -1b, and -2 antibodies in sera...
August 20, 2017: Transfusion
https://www.readbyqxmd.com/read/28830906/autosomal-recessive-chondrodysplasia-with-severe-short-stature-caused-by-a-biallelic-col10a1-variant
#19
Noor Ul Ain, Outi Makitie, Sadaf Naz
BACKGROUND: Heterozygous mutations in COL10A1 underlie metaphyseal chondrodysplasia, Schmid type (MCDS), an autosomal dominant skeletal dysplasia. OBJECTIVE: To identify the causative variant in a large consanguineous Pakistani family with severe skeletal dysplasia and marked lower limb deformity. METHODS: Whole exome sequencing was completed followed by Sanger sequencing to verify segregation of the identified variants. In silico variant pathogenicity predictions and amino acid conservation analyses were performed...
August 22, 2017: Journal of Medical Genetics
https://www.readbyqxmd.com/read/28830565/determinants-of-follow-up-care-associated-with-incident-antidepressant-use-in-older-adults
#20
Victoire Massamba, Helen-Maria Vasiliadis, Michel Préville
OBJECTIVES: To determine the proportion of older adults receiving guideline concordant antidepressant therapy and to determine patient, prescriber and organizational factors associated with adequate antidepressant therapy. METHODS: The study included secondary analyses of data collected in the Étude sur la Santé des Aînés (ESA) Services study on older adults recruited while consulting in primary care clinics in one of the largest health regions of the province of Québec...
August 22, 2017: BMC Research Notes
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