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https://www.readbyqxmd.com/read/29475127/brief-hypoxic-cycles-improve-uterine-contractile-function-after-prolonged-hypoxia-in-term-pregnant-but-not-in-nonpregnant-rats-in-vitro
#1
Mohammed Alotaibi
During labour, the uterus itself is vulnerable to hypoxia/ischemia that can occur with each strong contraction and this may ultimately cause dysfunctional labour in some women. Periods of Intermittent re-oxygenations are beneficial to tissues subjected to hypoxia to wash out metabolic by-products that have been accumulated during hypoxic stresses which may affect the tissue viability. We proposed that short intermittent hypoxic episodes may protect the uterus from subsequent sustained long hypoxia. To investigate this, two sets of experiments were performed on term-pregnant and nonpregnant rat uterine tissues...
February 12, 2018: Theriogenology
https://www.readbyqxmd.com/read/29475124/the-defensive-role-of-silicon-in-wheat-against-stress-conditions-induced-by-drought-salinity-or-cadmium
#2
Yahya Alzahrani, Alpaslan Kuşvuran, Hesham F Alharby, Sebnem Kuşvuran, Mostafa M Rady
In the crust of earth, silicon (Si) is one of the two major elements. For plant growth and development, importance of Si remains controversial due to the widely differences in ability of plants to take up this element. In this paper, pot experiments were done to study Si roles in improving salt, drought or cadmium (Cd) stress tolerance in wheat. Up to full emergence, all pots were watered at 100% field capacity (FC) every other day with nutrient solution without any treatments. Fifteen days after sowing, pots were divided into four plots, each with 40 pots for no stress (control) and three stress treatments; drought (50% FC), salinity (200 mM NaCl) and cadmium (2 mM Cd)...
February 20, 2018: Ecotoxicology and Environmental Safety
https://www.readbyqxmd.com/read/29475072/digital-gene-expression-profiling-reveals-transcriptional-responses-to-acute-cold-stress-in-chinese-soft-shelled-turtle-pelodiscus-sinensis-juveniles
#3
Wen-Yi Zhang, Cui-Juan Niu, Bo-Jian Chen, Kenneth B Storey
Turtles are well known for their stress tolerance, including an ability to deal with temperature extremes or rapid thermal change. To know more about the comprehensive molecular basis of thermal stress responses in turtles, we assessed differentially expressed genes (DEGs) in the brain, liver and kidney of juvenile soft-shelled turtles, Pelodiscus sinensis, after acute cold stress (28 °C-8 °C acute transfer and held for 12 h) and following recovery (back to 28 °C and held for 24 h) by digital gene expression profiling...
February 20, 2018: Cryobiology
https://www.readbyqxmd.com/read/29474667/the-transcription-factor-csbhlh18-of-sweet-orange-citrus-sinensis-functions-in-modulation-of-cold-tolerance-and-reactive-oxygen-species-homeostasis-by-regulating-the-antioxidant-gene
#4
Jingjing Geng, Ji-Hong Liu
The basic helix-loop-helix (bHLH) transcription factors (TFs) comprise one of the largest gene families in plants and participate in various physiological processes, but physiological role and regulatory function of the majority of bHLHs remain poorly understood. Here, a total of 56 putative CsbHLH genes were identified in sweet orange (Citrus sinensis) based on a genome-wide analysis. The CsbHLHs, except four members, were distributed throughout nine chromosomes and divided into 19 subgroups. Most of the CsbHLH genes were responsive to cold stress, with the greatest upregulation being observed in CsbHLH18...
February 21, 2018: Journal of Experimental Botany
https://www.readbyqxmd.com/read/29474202/a-decade-long-clinical-experience-on-the-prophylactic-use-of-activated-prothrombin-complex-concentrate-in-acquired-haemophilia-a-a-case-series-from-a-tertiary-care-centre
#5
Anita Árokszállási, Katalin Rázsó, Péter Ilonczai, Zsolt Oláh, Zsuzsanna Bereczky, Zoltán Boda, Ágota Schlammadinger
: In acquired haemophilia A (AHA), risk for recurrent bleeding exists until the inhibitor is detectable. Thus, patients with persisting inhibitor may benefit from prophylaxis with activated prothrombin complex concentrate (aPCC). Potential thromboembolic complications and cost are also factors to consider. Today, no high level evidence or clear recommendations are available on aPCC prophylaxis in AHA. Recently, a small prospective study demonstrated a favourable outcome with short-term, daily administered aPCC infusion...
February 22, 2018: Blood Coagulation & Fibrinolysis: An International Journal in Haemostasis and Thrombosis
https://www.readbyqxmd.com/read/29473986/riboflavin-induces-metarhizium-spp-to-produce-conidia-with-elevated-tolerance-to-uv-b-and-upregulates-photolyases-laccases-and-polyketide-synthases-genes
#6
Ronaldo A Pereira-Junior, Carla Huarte-Bonnet, Flávia R S Paixão, Donald W Roberts, Christian Luz, Nicolás Pedrini, Éverton K K Fernandes
AIMS: The effect of nutritional supplementation of two Metarhizium species with riboflavin (Rb) during production of conidia was (a) evaluated on conidial tolerance (based on germination) to UV-B radiation and (b) on conidial expression following UV-B irradiation, of enzymes known to be active in photoreactivation, viz., photolyase (Phr), laccase (Lcc) and polyketide synthase (Pks). METHODS AND RESULTS: Metarhizium acridum (ARSEF 324) and Metarhizium robertsii (ARSEF 2575) were grown either on (a) potato dextrose agar medium (PDA), (b) PDA supplemented with 1% yeast extract (PDAY), (c) PDA supplemented with Rb (PDA+Rb), or (d) PDAY supplemented with Rb (PDAY+Rb)...
February 23, 2018: Journal of Applied Microbiology
https://www.readbyqxmd.com/read/29473936/differential-survivorship-of-congeneric-ornamental-fishes-under-forecasted-climate-changes-are-related-to-anaerobic-potential
#7
Luciana Mara Fé Gonçalves, Maria de Nazaré Paula da Silva, Adalberto Luis Val, Vera Maria Fonseca de Almeida-Val
Two Amazonian closely related tetras - cardinal Paracheirodon axelrodi and green neon P. simulans - were artificially acclimatized to environmental chambers mimicking future climate change scenarios (mild, moderate and extreme), using a microcosm facility. P. simulans survived (100%) to all scenarios after 30 days exposure, while P. axelrodi presented decreasing survival percentages according to environmental severity. These differences may be the reflection of distinct natural acclimatization to microhabitats between the species, which differ in thermal conditions...
February 19, 2018: Genetics and Molecular Biology
https://www.readbyqxmd.com/read/29473848/bovine-%C3%AE-lactalbumin-hydrolysates-%C3%AE-lah-ameliorate-adipose-insulin-resistance-and-inflammation-in-high-fat-diet-fed-c57bl-6j-mice
#8
Jing Gao, Jiajia Song, Min Du, Xueying Mao
Obesity-induced adipose inflammation has been demonstrated to be a key cause of insulin resistance. Peptides derived from bovine α-lactalbumin have been shown to inhibit the activities of dipeptidyl peptidase IV (DPP-IV) and angiotensin converting enzyme (ACE), scavenge 2,2'-azinobis [3-ethylbenzothiazoline-6-sulfonate] (ABTS⁺) radical and stimulate glucagon-like peptide-2 secretion. In the present study, the effects of bovine α-lactalbumin hydrolysates (α-LAH) on adipose insulin resistance and inflammation induced by high-fat diet (HFD) were investigated...
February 23, 2018: Nutrients
https://www.readbyqxmd.com/read/29473728/highly-ordered-hierarchical-pt-and-ptni-nanowire-arrays-for-enhanced-electrocatalytic-activity-towards-methanol-oxidation
#9
Changzheng Wang, Yang Zhang, Yajun Zhang, Ping Xu, Cuimin Feng, Tao Chen, Tao Guo, Fengnan Yang, Qiang Wang, Jingxiao Wang, Mengtong Shi, Louzhen Fan, Shaowei Chen
Highly ordered hierarchical Pt and PtNi nanowire arrays were prepared by using CdS hierarchical nanowire arrays (HNWAs) as sacrificial templates and demonstrated high electrochemical active surface areas. For the resulting Pt HNWAs sample, the peak current for methanol oxidation at +0.74 V was almost one order of magnitude higher than that of Pt solid nanowire arrays (SNWAs) prepared in a similar manner but without the use of CdS template, and the addition of a Ni cocatalyst effectively enhanced the tolerance against CO poisoning...
February 23, 2018: ACS Applied Materials & Interfaces
https://www.readbyqxmd.com/read/29473705/alpha-1-antitrypsin-treatment-of-new-onset-type-1-diabetes-an-open-label-phase-i-clinical-trial-retain-to-assess-safety-and-pharmacokinetics
#10
Gordon C Weir, Mario R Ehlers, Kristina M Harris, Sai Kanaparthi, Alice Long, Deborah Phippard, Lia J Weiner, Brett Jepson, James G McNamara, Maria Koulmanda, Terry B Strom
OBJECTIVE: To determine the safety and pharmacokinetics of alpha-1 antitrypsin (AAT) in adults and children. RESEARCH DESIGN AND METHODS: Short term AAT treatment restores euglycemia in the non-obese mouse model of type 1 diabetes. A phase I multicenter study in 16 subjects with new-onset type 1 diabetes studied the safety and pharmacokinetics of Aralast NPTM (AAT). This open-label, dose-escalation study enrolled eight adults ages 16-35 and eight children ages 8-15 within 100 days of diagnosis, to receive 12 infusions of AAT: a low dose of 45 mg/kg weekly for six weeks, followed by a higher dose of 90 mg/kg for six weeks...
February 23, 2018: Pediatric Diabetes
https://www.readbyqxmd.com/read/29473527/glucose-lowering-activity-of-anvillea-radiata-coss-durieu-in-diabetic-rats
#11
Mohamed Eddouks, Morad Hebi
INTRODUCTION: Anvillea radiata Coss. &Durieu (Asteraceae) is an endemic plant from North Africa (Morocco and Algeria).This plant has many traditional uses including treatment of obesity and diabetes. AIM OF THE STUDY: the study aims to evaluate the antidiabetic effect of aqueous extract of Anvillea radiata (A. radiata) leaves on both normal and streptozotocin (STZ)-induced diabetic rats treated at a dose of 10 mg/kg body weight for fifteen days. In addition, a preliminary pytochemical screening for various components was realized...
February 22, 2018: Cardiovascular & Hematological Disorders Drug Targets
https://www.readbyqxmd.com/read/29473282/antioxidant-action-and-protective-and-reparative-effects-of-lentinan-on-oxidative-damage-in-hacat-cells
#12
Yusha Zi, Bo Zhang, Biao Jiang, Xingyao Yang, Zilu Liang, Weiyi Liu, Congfen He, Lei Liu
BACKGROUND: Lentinus edodes is one of the largest edible fungi. Lentinan, extracted from its fruiting body has clinically significant anticancer, antibacterial, antiviral, and anticoagulant effects; however, its preventive effects on skin oxidative damage are unclear. AIMS: We aimed to evaluate the in vitro antioxidation capability of lentinan and its protective and reparative effects on a model of cell oxidative damage. METHODS: We evaluated the in vitro antioxidant potential of lentinan by assessing its free-radical quenching ability using DPPH and ABTS and superoxide anions...
February 23, 2018: Journal of Cosmetic Dermatology
https://www.readbyqxmd.com/read/29472905/1-2-4-dichlorophenethyl-amino-3-phenoxypropan-2-ol-kills-pseudomonas-aeruginosa-through-extensive-membrane-damage
#13
Valerie Defraine, Veerle Liebens, Evelien Loos, Toon Swings, Bram Weytjens, Carolina Fierro, Kathleen Marchal, Liam Sharkey, Alex J O'Neill, Romu Corbau, Arnaud Marchand, Patrick Chaltin, Maarten Fauvart, Jan Michiels
The ever increasing multidrug-resistance of clinically important pathogens and the lack of novel antibiotics have resulted in a true antibiotic crisis where many antibiotics are no longer effective. Further complicating the treatment of bacterial infections are antibiotic-tolerant persister cells. Besides being responsible for the recalcitrant nature of chronic infections, persister cells greatly contribute to the observed antibiotic tolerance in biofilms and even facilitate the emergence of antibiotic resistance...
2018: Frontiers in Microbiology
https://www.readbyqxmd.com/read/29472867/human-milk-and-donkey-milk-compared-to-cow-milk-reduce-inflammatory-mediators-and-modulate-glucose-and-lipid-metabolism-acting-on-mitochondrial-function-and-oleylethanolamide-levels-in-rat-skeletal-muscle
#14
Giovanna Trinchese, Gina Cavaliere, Chiara De Filippo, Serena Aceto, Marina Prisco, Jong Tai Chun, Eduardo Penna, Rossella Negri, Laura Muredda, Andrea Demurtas, Sebastiano Banni, Roberto Berni-Canani, Giuseppina Mattace Raso, Antonio Calignano, Rosaria Meli, Luigi Greco, Marianna Crispino, Maria P Mollica
Scope: Milk from various species differs in nutrient composition. In particular, human milk (HM) and donkey milk (DM) are characterized by a relative high level of triacylglycerol enriched in palmitic acid in sn-2 position. These dietary fats seem to exert beneficial nutritional properties through N-acylethanolamine tissue modulation. The aim of this study is to compare the effects of cow milk (CM), DM, and HM on inflammation and glucose and lipid metabolism, focusing on mitochondrial function, efficiency, and dynamics in skeletal muscle, which is the major determinant of resting metabolic rate...
2018: Frontiers in Physiology
https://www.readbyqxmd.com/read/29472747/lercanidipine-in-the-management-of-hypertension-an-update
#15
REVIEW
Guido Grassi, Nicolàs R Robles, Gino Seravalle, Francesco Fici
Calcium channel blockers (CCBs), particularly dihydropyridine-CCBs, (DHP-CCBs), have an established role in antihypertensive therapy, either as monotherapy or in combination with other antihypertensive drugs. Two hundred and fifty-one papers published in PubMed in English between January 1, 1990, and October 31, 2016, were identified using the keyword "lercanidipine." Lercanidipine is a lipophilic third-generation DHP-CCB, characterized by high vascular selectivity and persistence in the smooth muscle cell membranes...
October 2017: Journal of Pharmacology & Pharmacotherapeutics
https://www.readbyqxmd.com/read/29472567/polyrotaxane-based-supramolecular-theranostics
#16
Guocan Yu, Zhen Yang, Xiao Fu, Bryant C Yung, Jie Yang, Zhengwei Mao, Li Shao, Bin Hua, Yijing Liu, Fuwu Zhang, Quli Fan, Sheng Wang, Orit Jacobson, Albert Jin, Changyou Gao, Xiaoying Tang, Feihe Huang, Xiaoyuan Chen
The development of smart theranostic systems with favourable biocompatibility, high loading efficiency, excellent circulation stability, potent anti-tumour activity, and multimodal diagnostic functionalities is of importance for future clinical application. The premature burst release and poor degradation kinetics indicative of polymer-based nanomedicines remain the major obstacles for clinical translation. Herein we prepare theranostic shell-crosslinked nanoparticles (SCNPs) using a β-cyclodextrin-based polyrotaxane (PDI-PCL-b-PEG-RGD⊃β-CD-NH2 ) to avoid premature drug leakage and achieve precisely controllable release, enhancing the maximum tolerated dose of the supramolecular nanomedicines...
February 22, 2018: Nature Communications
https://www.readbyqxmd.com/read/29472310/temozolomide-plus-bevacizumab-in-elderly-patients-with-newly-diagnosed-glioblastoma-and-poor-performance-status-an-anocef-phase-ii-trial-atag
#17
Germán Reyes-Botero, Stéphanie Cartalat-Carel, Olivier L Chinot, Maryline Barrie, Luc Taillandier, Patrick Beauchesne, Isabelle Catry-Thomas, Jérôme Barrière, Jean-Sebastien Guillamo, Michel Fabbro, Didier Frappaz, Alexandra Benouaich-Amiel, Emilie Le Rhun, Chantal Campello, Isabelle Tennevet, François Ghiringhelli, Marie-Laure Tanguy, Karima Mokhtari, Jérôme Honnorat, Jean-Yves Delattre
LESSONS LEARNED: Results suggest that the combination of bevacizumab plus temozolomide is active in terms of response rate, survival, performance, quality of life, and cognition in elderly patients with glioblastoma multiforme with poor performance status.Whether this combination is superior to temozolomide alone remains to be demonstrated by a randomized study. BACKGROUND: The optimal treatment of glioblastoma multiforme (GBM) in patients aged ≥70 years with a Karnofsky performance status (KPS) <70 is not established...
February 22, 2018: Oncologist
https://www.readbyqxmd.com/read/29472278/siamese-related1-is-regulated-post-translationally-and-participates-in-repression-of-leaf-growth-under-moderate-drought
#18
Marieke Dubois, Katia Selden, Alexis Bediée, Gaëlle Rolland, Nicolas Baumberger, Sandra Noir, Lien Bach, Geneviève Lamy, Christine Granier, Pascal Genschik
The plant cell cycle is tightly regulated by factors that integrate endogenous cues and environmental signals to adapt plant growth to changing conditions. Under drought, cell division in young leaves is blocked by an active mechanism, reducing the evaporative surface and conserving energy resources. The molecular function of cyclin-dependent kinase-inhibitory proteins (CKIs) in regulating the cell cycle has already been well studied, but little is known about their involvement in cell cycle regulation under adverse growth conditions...
February 22, 2018: Plant Physiology
https://www.readbyqxmd.com/read/29472241/adrenal-activity-and-metabolic-risk-during-randomized-escitalopram-or-placebo-treatment-in-pcos
#19
Dorte Glintborg, Magda Lambaa Altinok, Pernille Ravn, Kurt B Stage, Kurt Højlund, Marianne Andersen
BACKGROUND/AIMS: Polycystic ovary syndrome (PCOS) is associated with insulin resistance, adrenal hyperactivity and decreased mental health. We aimed to investigate changes in adrenal activity, metabolic status, and mental health in PCOS during treatment with escitalopram or placebo. METHODS: Forty-two overweight premenopausal women with PCOS and no clinical depression were randomized to 12-weeks SSRI (20 mg escitalopram/day, n=21) or placebo (n=21). Patients underwent clinical examination, fasting blood samples, adrenocorticotroph hormone (ACTH) test, 3 hours oral glucose tolerance test (OGTT) and filled in questionnaires regarding mental health and health related quality of life (HRQoL): WHO Well Being Index (WHO-5), Major Depression Inventory (MDI), Short Form 36 (SF-36), and PCOS questionnaire...
February 22, 2018: Endocrine Connections
https://www.readbyqxmd.com/read/29471899/principles-for-constructing-a-tuberculosis-treatment-regimen-the-role-and-definition-of-core-and-companion-drugs
#20
A Van Deun, T Decroo, A Piubello, B C de Jong, L Lynen, H L Rieder
Current World Health Organization guidelines for the formulation of treatment regimens for multidrug-resistant tuberculosis (MDR-TB) pay too little attention to the microbiological activity of anti-tuberculosis drugs. Here, we draw lessons from the pioneering work done on shorter MDR-TB treatment regimens and the current knowledge of the bactericidal and sterilizing properties of the drugs to inform the composition of treatment regimens for MDR-TB. We propose to reserve the term 'core drug' for the one drug in a regimen that contributes most to relapse-free cure...
March 1, 2018: International Journal of Tuberculosis and Lung Disease
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