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Small fir gestational age

Suja Padmanabhan, Vincent W Lee, Mark Mclean, Neil Athayde, Valeria Lanzarone, Qemer Khoshnow, Michael J Peek, N Wah Cheung
OBJECTIVE: To investigate the association of falling insulin requirements (FIR) among women with preexisting diabetes with adverse obstetric outcomes and maternal biomarkers longitudinally in pregnancy. RESEARCH DESIGN AND METHODS: A multicenter prospective cohort study of 158 women (41 with type 1 diabetes and 117 with type 2 diabetes) was conducted. Women with FIR of ≥15% from the peak total daily dose after 20 weeks' gestation were considered case subjects ( n = 32)...
October 2017: Diabetes Care
Ingela Hulthén Varli, Marius Kublickas, Nikos Papadogiannakis, Karin Petersson
OBJECTIVE: The aim of this study was to compare placental findings from early preterm stillbirths with gestational week-matched liveborn infants. The main focus was to investigate the differences in the presence and distribution of inflammatory signs in the placentas of these two groups, especially referring to histological acute chorioamnionitis (CAM). METHODS: A case-control study of preterm stillbirths, between 22 and 32 weeks gestation, here referred to as early preterm, (cases, n = 112) and gestational week-matched liveborn infants (references, n = 166) in Stockholm...
July 2013: Journal of Maternal-fetal & Neonatal Medicine
D O El-Haieg, A A Zidan, M M El-Nemr
OBJECTIVE: To assess the relation between sonographic fetal thymus size and the components of fetal inflammatory response syndrome (FIRS) in women with preterm prelabour rupture of membranes (PPROM). DESIGN: Prospective cohort study. SETTING: University hospital from January through October 2006. POPULATION: Fifty-six women with PPROM. METHODS: In these women, fetal thymus perimeter was measured sonographically...
June 2008: BJOG: An International Journal of Obstetrics and Gynaecology
R Romero, J Espinoza, L F Gonçalves, R Gomez, L Medina, M Silva, T Chaiworapongsa, B H Yoon, F Ghezzi, W Lee, M Treadwell, S M Berry, E Maymon, M Mazor, G DeVore
BACKGROUND: Preterm premature rupture of membranes (PROM) is associated with one-third of preterm births. In about 50% of preterm PROM cases, the fetuses will elicit a fetal inflammatory response syndrome (FIRS). FIRS is associated with the impending onset of preterm labor, periventricular leukomalacia, neonatal sepsis, and long-term handicap, including the development of bronchopulmonary dysplasia and cerebral palsy. The fetal myocardium is a potential target organ of proinflammatory cytokines released during FIRS...
September 2004: Journal of Maternal-fetal & Neonatal Medicine
Margreet A Veening, Mirjam M van Weissenbruch, Robert J Heine, Henriette A Delemarre-van de Waal
Insulin secretion and sensitivity was studied in 28 prepubertal children born small for gestational age (SGA) and in 22 prepubertal children born appropriate for gestational age (AGA). The effect of body size during childhood was also assessed. Insulin sensitivity was measured using the hyperinsulinemic-euglycemic clamp (M value), and beta-cell function was studied with the hyperglycemic clamp plus arginine. First-phase insulin response (FIR) was used to calculate the disposition index (FIR x M value). Arginine-stimulated second-phase insulin response was used as a measure of beta-cell capacity...
July 2003: Diabetes
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