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https://www.readbyqxmd.com/read/28533230/deletion-of-pikfyve-alters-alveolar-macrophage-populations-and-exacerbates-allergic-inflammation-in-mice
#1
Takumi Kawasaki, Kosuke Ito, Haruhiko Miyata, Shizuo Akira, Taro Kawai
Alveolar macrophages (AMs) are specialized tissue-resident macrophages that orchestrate the immune responses to inhaled pathogens and maintain organ homeostasis of the lung. Dysregulation of AMs is associated with allergic inflammation and asthma. Here, we examined the role of a phosphoinositide kinase PIKfyve in AM development and function. Mice with conditionally deleted PIKfyve in macrophages have altered AM populations. PIKfyve deficiency results in a loss of AKT activation in response to GM-CSF, a cytokine critical for AM development...
May 22, 2017: EMBO Journal
https://www.readbyqxmd.com/read/28532198/provider-perceptions-on-hiv-risk-and-prevention-services-within-permanent-supportive-housing
#2
Suzanne L Wenzel, Benjamin Henwood, Taylor Harris, Hailey Winetrobe, Harmony Rhoades
Permanent supportive housing (PSH) is an evidence-based solution to homelessness for persons experiencing chronic or long-term homelessness and one or more physical or behavioral health problems. Health services through PSH typically focus on physical and behavioral health. With the exception of programs specifically designed for persons living with HIV/AIDS, little attention has focused on services through PSH to prevent transmission of HIV or other sexually transmitted infections (STIs), yet sexual risk behavior continues after homeless persons move into PSH...
May 22, 2017: AIDS Care
https://www.readbyqxmd.com/read/28518173/simultaneous-quantification-of-n-and-o-glycans-using-a-solid-phase-method
#3
Shuang Yang, Yingwei Hu, Lori Sokoll, Hui Zhang
Glycosylation has a pivotal role in a diverse range of biological activities, modulating the structure and function of proteins. Glycogens coupled to the nitrogen atom (N-linked) of asparagine side chains or to the oxygen atom (O-linked) of serine and threonine side chains represent the two major protein glycosylation forms. N-glycans can be released by glycosidases, whereas O-glycans are often cleaved by chemical reaction. However, it is challenging to combine these enzymatic and chemical reactions in order to analyze both N- and O-glycans...
June 2017: Nature Protocols
https://www.readbyqxmd.com/read/28516728/increased-heterogeneity-of-airway-calibre-in-adult-rats-after-hypoxia-induced-intrauterine-growth-restriction
#4
Kimberley C W Wang, Jude S Morton, Sandra T Davidge, Alexander N Larcombe, Alan L James, Graham M Donovan, Peter B Noble
BACKGROUND AND OBJECTIVE: Intrauterine growth restriction (IUGR) is associated with asthma development. We hypothesized that IUGR disrupts airway development leading to postnatal structural abnormalities of the airway that predispose to disease. This study therefore examined structural changes to the airway and lung in a rat model of maternal hypoxia-induced IUGR. METHODS: Pregnant rats were housed under hypoxic conditions (11.5% O2 ) from gestational days (GDs) 13 to 20 (pseudoglandular-canalicular stages, i...
May 17, 2017: Respirology: Official Journal of the Asian Pacific Society of Respirology
https://www.readbyqxmd.com/read/28516487/the-petrosal-and-bony-labyrinth-of-diplobune-minor-an-enigmatic-artiodactyla-from-the-oligocene-of-western-europe
#5
Maeva J Orliac, Ricardo Araújo, Fabrice Lihoreau
Anoplotheriinae are Paleogene European artiodactyls that present a unique postcranial morphology with a tridactyl autopodium and uncommon limb orientation. This peculiar morphology led to various hypotheses regarding anoplotheriine locomotion from semiaquatic to partly arboreal or partly bipedal. The petrosal bone, housing the organs of balance, and hearing, offers complementary information to postcranial morphology on the ecology of this uncommon artiodactyl. Here, we investigate the middle ear and bony labyrinth of the small anoplotheriine Diplobune minor based on four specimens from the Early Oligocene locality of Itardies (Quercy, France)...
May 17, 2017: Journal of Morphology
https://www.readbyqxmd.com/read/28515831/the-relationship-of-living-environment-with-behavioral-and-fitness-outcomes-by-sex-an-exploratory-study-in-college-aged-students
#6
Kaelah Shaffer, Melissa Bopp, Zack Papalia, Dangaia Sims, Christopher M Bopp
Although physical activity (PA) is associated with several health benefits, there is a marked decline during college years, which is an influential period for the development of health behaviors. This study examined the relationship of neighborhood and living environment with behavioral (PA and sedentary behavior) and fitness outcomes by sex. Participants were college students that participated in a fitness assessment, followed by a survey that measured self-reported exercise and perception of one's environment (sidewalks, crime, traffic, access to PA resources in their neighborhood and/or apartment complex)...
2017: International Journal of Exercise Science
https://www.readbyqxmd.com/read/28513853/association-between-textural-and-morphological-tumor-indices-on-baseline-pet-ct-and-early-metabolic-response-on-interim-pet-ct-in-bulky-malignant-lymphomas
#7
Fayçal Ben Bouallègue, Yassine Al Tabaa, Marilyne Kafrouni, Guillaume Cartron, Fabien Vauchot, Denis Mariano-Goulart
PURPOSE: We investigated whether metabolic, textural and morphological tumoral indices evaluated on baseline PET-CT were predictive of early metabolic response on interim PET-CT in a cohort of patients with bulky Hodgkin and non-Hodgkin malignant lymphomas. METHODS: This retrospective study included 57 patients referred for initial PET-CT examination. In-house dedicated software was used to delineate tumor contours using a fixed 30% threshold of SUV max and then to compute tumoral metabolic parameters (SUV max, mean, peak, standard deviation, skewness and kurtosis, metabolic tumoral volume (MTV), total lesion glycolysis, and area under the curve of the cumulative histogram), textural parameters (Moran's and Geary's indices, energy, entropy, contrast, correlation derived from the gray-level co-occurrence matrix, area under the curve of the power spectral density, auto-correlation distance, and granularity), and shape parameters (surface, asphericity, convexity, surfacic extension, and 2D and 3D fractal dimensions)...
May 17, 2017: Medical Physics
https://www.readbyqxmd.com/read/28513615/exome-sequencing-of-two-italian-pedigrees-with-non-isolated-chiari-malformation-type-i-reveals-candidate-genes-for-cranio-facial-development
#8
Elisa Merello, Lorenzo Tattini, Alberto Magi, Andrea Accogli, Gianluca Piatelli, Marco Pavanello, Domenico Tortora, Armando Cama, Zoha Kibar, Valeria Capra, Patrizia De Marco
Chiari malformation type I (CMI) is a congenital abnormality of the cranio-cerebral junction with an estimated incidence of 1 in 1280. CMI is characterized by underdevelopment of the occipital bone and posterior fossa (PF) and consequent cerebellar tonsil herniation. The presence for a genetic basis to CMI is supported by many lines of evidence. The cellular and molecular mechanisms leading to CM1 are poorly understood. The occipital bone formation is dependent on complex interactions between genes and molecules with pathologies resulting from disruption of this delicate process...
May 17, 2017: European Journal of Human Genetics: EJHG
https://www.readbyqxmd.com/read/28513406/-the-court-physician-the-clergyman-a-learned-society-and-smallpox
#9
H F P Hillen
Variolation was introduced in England in the first half of the 18th century. The positive effects of this new method for preventing smallpox were already known in the Netherlands around 1720, one of whom was the Dutch physician Boerhaave. In spite of this, it took another 30 years before variolation was used in the Netherlands. Despite receiving positive advice and information from his learned English friends Sloane and Sherard, Boerhaave did not apply nor advise the use of variolation. There were various arguments for this restrained approach...
2017: Nederlands Tijdschrift Voor Geneeskunde
https://www.readbyqxmd.com/read/28511186/search-for-internal-cancers-in-mice-tattooed-with-inks-of-high-contents-of-potential-carcinogens-a-one-year-autopsy-study-of-red-and-black-tattoo-inks-banned-in-the-market
#10
Mitra Sepehri, Catharina M Lerche, Katrina Hutton Carlsen, Jørgen Serup
BACKGROUND AND OBJECTIVE: Tattoo ink stock products often contain potential carcinogens, which on large-scale population exposure may be clinically relevant. The aim of this autopsy study in mice was to screen major organs for clinical and subclinical cancers. METHODS: Mice were tattooed on their backs. In total, 48 mice were included and divided into 4 groups; 11 mice tattooed black, 10 tattooed red, and 5 mice serving as untreated controls. A group of 22 mice with black tattoos and exposed to ultraviolet radiation (UVR) were also studied...
May 17, 2017: Dermatology: International Journal for Clinical and Investigative Dermatology
https://www.readbyqxmd.com/read/28510656/associations-of-environmental-factors-with-quality-of-life-in-older-adults
#11
Robbert J J Gobbens, Marcel A L M van Assen
Purpose of the Study: Environmental factors play an important role in the quality of life of older people who often have difficulty maintaining physical, psychological, and social functioning. In this study, we aimed at (a) developing a measurement instrument assessing the factors of older adults' perceptions of their environment, (b) examining the associations of these environmental factors with quality of life domains physical health, psychological, social relations, and environmental, controlling for background characteristics...
May 16, 2017: Gerontologist
https://www.readbyqxmd.com/read/28508123/photochemically-controlled-drug-dosing-from-a-polymeric-scaffold
#12
Louise Donnelly, John G Hardy, Sean P Gorman, David S Jones, Nicola J Irwin, Colin P McCoy
PURPOSE: To develop the first photoactive biomaterial coating capable of controlled drug dosing via inclusion of synthesised drug-3,5-dimethoxybenzoin (DMB) conjugates in a poly(2-methyoxyethyl acrylate) (pMEA) scaffold. METHODS: Flurbiprofen- and naproxen-DMB conjugates were prepared via esterification and characterised via NMR spectroscopy and mass spectrometry following chromatographic purification. Conjugate photolysis was investigated in acetonitrile solution and within the pMEA matrix following exposure to low-power 365 nm irradiation...
May 15, 2017: Pharmaceutical Research
https://www.readbyqxmd.com/read/28508106/differential-effects-of-pair-housing-on-voluntary-nicotine-consumption-a-comparison-between-male-and-female-adolescent-rats
#13
Hyunchan Lee, Minji Jang, Woonhee Kim, Jihyun Noh
RATIONALE: Tobacco smoking occurs in a wide array of social circumstances. Social support for quitting is generally used to stop smoking, while peer interactions may be a crucial factor in triggering tobacco use among adolescents. OBJECTIVES: To determine the role of social factors on nicotine dependence, we compared single- and pair-housed rats subjected to voluntary oral nicotine consumption tests. METHODS: Six-week-old adolescent rats were subjected to experimental procedures and assigned to one of the following groups: a male single group, a male pair group with a sibling, a female single group, and a female pair group with a sibling...
May 15, 2017: Psychopharmacology
https://www.readbyqxmd.com/read/28505697/-the-development-of-palliative-care-hospital-support-teams-hpcts-in-bavaria-from-2011-2015-tasks-acceptance-structure-and-funding
#14
Johanna Anneser, Tamara Thurn, Gian Domenico Borasio
Introduction Palliative care hospital support teams (HPCTs) provide inpatients from all departments palliative medical support. Seriously ill as well as dying patients, who are being treated in facilities that do not have their own palliative care unit, can benefit from these multi-professional teams just as much as patients who do not (yet) need to be admitted to a palliative care unit. At the end of 2015, 53 HPCTs, which were in accordance with the requirements established in the "Program for HPCTs" by the Bavarian Ministry of Health in 2009, had been approved in Bavaria...
May 15, 2017: Das Gesundheitswesen
https://www.readbyqxmd.com/read/28505588/hydroxylated-2-ethylhexyl-tetrabromobenzoate-isomers-in-house-dust-and-their-agonistic-potencies-with-several-nuclear-receptors
#15
Hui Peng, Jianxian Sun, David M V Saunders, Garry Codling, Steve Wiseman, Paul D Jones, John P Giesy
In the current study, by combining ultra-high resolution (UHR) MS(1) spectra, MS(2) spectra, and derivatization, three hydroxylated isomers of 2-ethylhexyl tetrabromobenzoate (OH-TBB) were identified in Firemaster(®) 550 and BZ-54 technical products. Also, a new LC-UHRMS method, using atmospheric pressure chemical ionization (APCI), was developed for simultaneous analysis of OH-TBB, TBB, hydroxylated bis(2-ethylhexyl)-tetrabromophthalate (OH-TBPH) and TBPH in 23 samples of dust collected from houses in Saskatoon, SK, Canada...
May 12, 2017: Environmental Pollution
https://www.readbyqxmd.com/read/28505488/predictors-of-buprenorphine-treatment-success-of-opioid-dependence-in-two-baltimore-city-grassroots-recovery-programs
#16
April Joy Damian, Tamar Mendelson, Deborah Agus
INTRODUCTION: Despite evidence for the efficacy of buprenorphine treatment in primary care, few studies have identified factors associated with treatment success, nor have such factors been evaluated in community settings. Identifying correlates of treatment success can facilitate the development of treatment models tailored for distinct populations, including low-income communities of color. The current study examined client-level socio-demographic factors associated with treatment success in community-based buprenorphine programs serving vulnerable populations...
May 10, 2017: Addictive Behaviors
https://www.readbyqxmd.com/read/28505141/a-decade-of-progress-toward-ending-the-intensive-confinement-of-farm-animals-in-the-united-states
#17
Sara Shields, Paul Shapiro, Andrew Rowan
In this paper, the Humane Society of the United States (HSUS) farm animal protection work over the preceding decade is described from the perspective of the organization. Prior to 2002, there were few legal protections for animals on the farm, and in 2005, a new campaign at the HSUS began to advance state ballot initiatives throughout the country, with a decisive advancement in California (Proposition 2) that paved the way for further progress. Combining legislative work with undercover farm and slaughterhouse investigations, litigation and corporate engagement, the HSUS and fellow animal protection organizations have made substantial progress in transitioning the veal, pork and egg industries away from intensive confinement systems that keep the animals in cages and crates...
May 15, 2017: Animals: An Open Access Journal From MDPI
https://www.readbyqxmd.com/read/28498334/pastoralism-versus-agriculturalism-how-do-altered-land-use-forms-affect-the-spread-of-invasive-plants-in-the-degraded-mutara-rangelands-of-north-eastern-rwanda
#18
Torsten Wronski, Jean Damascene Bariyanga, Ping Sun, Martin Plath, Ann Apio
Lantana camara L. (Verbenaceae) originates from tropical Central and South America and has become invasive in about 50 countries. It causes problems when invading rangelands due to its toxicity to livestock and its tendency to form dense, monotonous thickets. Its invasiveness can partly be explained by the high tannin content largely protecting the species from being browsed, its tolerance to a wide range of environmental conditions, as well as its general preference for anthropogenically disturbed habitats...
May 12, 2017: Plants (Basel, Switzerland)
https://www.readbyqxmd.com/read/28497671/perceived-efficacy-and-satisfaction-of-patients-with-subcutaneous-hypoallergenic-high-dose-house-dust-mite-extract
#19
A Roger Reig, M Ibero Iborra, T Carrillo Díaz, R López Abad, V Sánchez Moreno, J Álvarez Nieto, N Cancelliere
The efficacy and safety of subcutaneous immunotherapy with modified, high-dose, major allergen house dust mite extract is widely supported by double-blind, placebo-controlled studies. However, little is known regarding patient-perceived efficacy and satisfaction. An observational, retrospective, multicentre study in patients treated with Acaroid(®) was conducted to assess the efficacy and degree of satisfaction of the patients after the first six months of treatment with it. All the clinical study procedures were performed according to the routine clinical practice...
May 2017: European Annals of Allergy and Clinical Immunology
https://www.readbyqxmd.com/read/28495219/increases-in-use-and-activity-due-to-urban-renewal-effect-of-a-natural-experiment
#20
Henriette Bondo Andersen, Lars Breum Christiansen, Charlotte Demant Klinker, Annette Kjær Ersbøll, Jens Troelsen, Jacqueline Kerr, Jasper Schipperijn
INTRODUCTION: Urban green space and other recreational facilities are associated with physical activity. For adolescents living in multistory housing, public outdoor spaces that support physical activity may play an important role in activity promotion strategies. However, stronger evidence for a relation between the built environment and adolescent physical activity is scarce. DESIGN: A natural experiment with a pre-experimental design was used with data collected in 2010 and 2012 before and after an urban renewal...
May 8, 2017: American Journal of Preventive Medicine
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