Naureen Keric, Harald Krenzlin, Darius Kalasauskas, Christian F Freyschlag, Oliver Schnell, Martin Misch, Christian von der Brelie, Jens Gempt, Aleksandrs Krigers, Arthur Wagner, Felipa Lange, Dorothee Mielke, Clemens Sommer, Marc A Brockmann, Bernhard Meyer, Veit Rohde, Peter Vajkoczy, Jürgen Beck, Claudius Thomé, Florian Ringel
BACKGROUND: Isocitrate dehydrogenase (IDH)1/2 wildtype (wt) astrocytomas formerly classified as WHO grade II or III have significantly shorter PFS and OS than IDH mutated WHO grade 2 and 3 gliomas leading to a classification as CNS WHO grade 4. It is the aim of this study to evaluate differences in the treatment-related clinical course of these tumors as they are largely unknown. METHODS: Patients undergoing surgery (between 2016-2019 in six neurosurgical departments) for a histologically diagnosed WHO grade 2-3 IDH1/2-wt astrocytoma were retrospectively reviewed to assess progression free survival (PFS), overall survival (OS), and prognostic factors...
February 7, 2024: Journal of Neuro-oncology