Shuanzeng Wei, Harris B Krause, Daniel M Geynisman, Andrew Elliott, Alexander Kutikov, Robert G Uzzo, Jianming Pei, Pedro Barata, Benedito Carneiro, Elisabeth Heath, Charles Ryan, Alex Farrell, Chadi Nabhan, Rouba Ali-Fehmi, Abdul Rafeh Naqash, Pedram Argani, Rana R McKay
TFE3-rearranged renal cell carcinoma (rRCC) is a rare subtype of renal cell carcinomas belonging to the MiT family translocation RCC. To further elucidate the co-alterations that occur along with TFE3 fusions in rRCC, we characterized the genomic, transcriptional, and immune landscapes in comparison to clear cell (ccRCC) and papillary renal cell carcinoma (pRCC). Next-generation sequencing of RNA (whole transcriptome) and DNA (592-gene panel or whole exome) for rRCC (N = 20), pRCC (N = 20), and ccRCC samples (N = 392) was performed...
February 2024: Modern Pathology