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https://www.readbyqxmd.com/read/26341227/immortalization-of-pig-fibroblast-cells-by-transposon-mediated-ectopic-expression-of-porcine-telomerase-reverse-transcriptase
#1
Shan He, Yangyang Li, Yang Chen, Yue Zhu, Xinyu Zhang, Xiaoli Xia, Huaichang Sun
Pigs are the most economically important livestock, but pig cell lines useful for physiological studies and/or vaccine development are limited. Although several pig cell lines have been generated by oncogene transformation or human telomerase reverse transcriptase (TERT) immortalization, these cell lines contain viral sequences and/or antibiotic resistance genes. In this study, we established a new method for generating pig cell lines using the Sleeping Beauty (SB) transposon-mediated ectopic expression of porcine telomerase reverse transcriptase (pTERT)...
August 2016: Cytotechnology
https://www.readbyqxmd.com/read/25962353/cloning-and-molecular-characterization-of-telomerase-reverse-transcriptase-tert-and-telomere-length-analysis-of-peromyscus-leucopus
#2
Xin Zhao, Yasutaka Ueda, Sachiko Kajigaya, Glen Alaks, Marie J Desierto, Danielle M Townsley, Bogdan Dumitriu, Jichun Chen, Robert C Lacy, Neal S Young
Telomerase reverse transcriptase (TERT) is the catalytic subunit of telomerase complex that regulates telomerase activity to maintain telomere length for all animals with linear chromosomes. As the Mus musculus (MM) laboratory mouse has very long telomeres compared to humans, a potential alternative animal model for telomere research is the Peromyscus leucopus (PL) mouse that has telomere lengths close to the human range and has the wild counterparts for comparison. We report the full TERT coding sequence (pTERT) from PL mice to use in the telomere research...
August 15, 2015: Gene
https://www.readbyqxmd.com/read/24510582/telomere-elongation-facilitated-by-trichostatin-a-in-cloned-embryos-and-pigs-by-somatic-cell-nuclear-transfer
#3
Qingran Kong, Guangzhen Ji, Bingteng Xie, Jingyu Li, Jian Mao, Juan Wang, Shichao Liu, Lin Liu, Zhonghua Liu
Telomere attrition and genomic instability are associated with organism aging. Concerns still exist regarding telomere length resetting in cloned embryos and ntES cells, and possibilities of premature aging of cloned animals achieved by somatic cell nuclear transfer (SCNT). Trichostatin A (TSA), a histone deacetylase inhibitor, effectively improves the developmental competence of cloned embryos and animals, and recently contributes to successful generation of human ntES cells by SCNT. To test the function of TSA on resetting telomere length, we analyzed telomeres in cloned blastocysts and pigs following treatment of SCNT embryos with TSA...
June 2014: Stem Cell Reviews
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