Sarah Benton, Jeffrey Zhao, Bin Zhang, Armita Bahrami, Raymond L Barnhill, Klaus Busam, Lorenzo Cerroni, Martin G Cook, Arnaud de la Fouchardière, David E Elder, Iva Johansson, Gilles Landman, Alexander Lazar, Philip LeBoit, Lori Lowe, Daniela Massi, Lyn M Duncan, Jane Messina, Daniela Mihic-Probst, Martin C Mihm, Michael W Piepkorn, Birgitta Schmidt, Richard A Scolyer, Christopher R Shea, Michael T Tetzlaff, Victor A Tron, Xiaowei Xu, Iwei Yeh, Sook Jung Yun, Artur Zembowicz, Pedram Gerami
Atypical Spitzoid melanocytic tumors are diagnostically challenging. Many studies have suggested various genomic markers to improve classification and prognostication. We aimed to assess whether next-generation sequencing studies using the Tempus xO assay assessing mutations in 1711 cancer-related genes and performing whole transcriptome mRNA sequencing for structural alterations could improve diagnostic agreement and accuracy in assessing neoplasms with Spitzoid histologic features. Twenty expert pathologists were asked to review 70 consultation level cases with Spitzoid features, once with limited clinical information and again with additional genomic information...
December 1, 2021: American Journal of Surgical Pathology