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https://www.readbyqxmd.com/read/28095541/safety-and-efficacy-evaluation-of-pulsed-dye-laser-treatment-co-sub-2-sub-ablative-fractional-resurfacing-and-combined-treatment-for-surgical-scar-clearance
#1
Joel L Cohen, Roy Geronemus
BACKGROUND & OBJECTIVE: Surgical scars are an unwanted sequela following surgical procedures. Several different treatment modalities and approaches are currently being employed to improve the cosmesis of surgical scars with each having varying degrees of success. The objective of this study was to assess the ef cacy and safety pulsed dye laser treatment, CO2 ablative fractional resurfacing, and a combined treatment with these two modalities for the cosmetic improvement of surgical scarring that occurred following the surgical removal of skin cancer from different anatomic areas...
November 1, 2016: Journal of Drugs in Dermatology: JDD
https://www.readbyqxmd.com/read/28093609/periprosthetic-fracture-around-a-stable-femoral-stem-treated-with-locking-plate-osteosynthesis-distal-femoral-locking-plate-alone-versus-with-cerclage-cable
#2
Young-Soo Shin, Seung-Beom Han
To promote rapid bone healing, an adequate stable fixation implant with a percutaneous reduction instrument should be used for Vancouver type B1 or C fractures. The objective of this study was to describe radiographic and clinical outcomes of patients with periprosthetic fracture (PPF) around a stable femoral stem, treated with a distal femoral locking plate alone or with a cerclage cable. A total of 21 patients with PPF amenable to either a reverse distal femoral locking plate (LCP DF(®)) alone or with a cerclage cable, with a mean age of 75...
January 16, 2017: European Journal of Orthopaedic Surgery & Traumatology: Orthopédie Traumatologie
https://www.readbyqxmd.com/read/28086787/perceptions-of-a-drug-prevention-public-service-announcement-campaign-among-street-involved-youth-in-vancouver-canada-a-qualitative-study
#3
Lianlian Ti, Danya Fast, William Small, Thomas Kerr
BACKGROUND: Due to the popularity of public service announcements (PSAs), as well as the broader health and social harms associated with illicit drug use, this study sought to investigate how drug prevention messages found in the Government of Canada's DrugsNot4Me campaign were understood, experienced, and engaged with among a group of street-involved young people in Vancouver, Canada. METHODS: Qualitative interviews were conducted with 25 individuals enrolled in the At-Risk Youth Study, and a thematic analysis was conducted...
January 13, 2017: Harm Reduction Journal
https://www.readbyqxmd.com/read/28080992/microevolutionary-traits-and-comparative-population-genomics-of-the-emerging-pathogenic-fungus-cryptococcus-gattii
#4
Rhys A Farrer, Kerstin Voelz, Daniel A Henk, Simon A Johnston, Matthew C Fisher, Robin C May, Christina A Cuomo
Emerging fungal pathogens cause an expanding burden of disease across the animal kingdom, including a rise in morbidity and mortality in humans. Yet, we currently have only a limited repertoire of available therapeutic interventions. A greater understanding of the mechanisms of fungal virulence and of the emergence of hypervirulence within species is therefore needed for new treatments and mitigation efforts. For example, over the past decade, an unusual lineage of Cryptococcus gattii, which was first detected on Vancouver Island, has spread to the Canadian mainland and the Pacific Northwest infecting otherwise healthy individuals...
December 5, 2016: Philosophical Transactions of the Royal Society of London. Series B, Biological Sciences
https://www.readbyqxmd.com/read/28072666/outcomes-from-referrals-and-unscheduled-visits-from-community-emergency-departments-to-a-regional-pediatric-emergency-department-in-canada
#5
Ethan Reiner, Ardalan Ahmadi, Eric Grafstein, Quynh Doan
OBJECTIVES: Existing pediatric literature describing repeat visits to the emergency department (ED) for the same medical complaint has yet to report on patient flow patterns from general EDs (GEDs) to a pediatric ED (PED). We sought to characterize the population of patients who are treated in a GED and subsequently present to a PED for further care. METHODS: We conducted a retrospective cohort study reviewing all pediatric visits (age < 17 y) at 5 GEDs in Vancouver...
January 9, 2017: Pediatric Emergency Care
https://www.readbyqxmd.com/read/28063691/clinical-risk-factors-for-punctate-white-matter-lesions-on-early-magnetic-resonance-imaging-in-preterm-newborns
#6
Nienke Wagenaar, Vann Chau, Floris Groenendaal, Karina J Kersbergen, Kenneth J Poskitt, Ruth E Grunau, Anne Synnes, Emma G Duerden, Linda S de Vries, Steven P Miller, ManonJ N L Benders
OBJECTIVE: To identify clinical risk factors for punctate white matter lesions (PWML) on early magnetic resonance imaging (MRI) in 2 cohorts of newborns born extremely preterm in different neonatal centers. STUDY DESIGN: A total of 250 newborns born preterm at less than 28 weeks of gestation (mean 26.4 ± 1.1 weeks) with an early MRI were identified from 2 neonatal centers, in Vancouver, Canada (cohort A, n = 100) and Utrecht, the Netherlands (cohort B, n = 150)...
January 4, 2017: Journal of Pediatrics
https://www.readbyqxmd.com/read/28061017/feasibility-and-safety-of-extended-release-naltrexone-treatment-of-opioid-and-alcohol-use-disorder-in-hiv-clinics-a-pilot-feasibility-randomized-trial
#7
P Todd Korthuis, Paula J Lum, Pamela Vergara-Rodriguez, Keith Ahamad, Evan Wood, Lynn E Kunkel, Neal L Oden, Robert Lindblad, James L Sorensen, Virgilio Arenas, Doan Ha, Raul N Mandler, Dennis Mccarty
BACKGROUND AND AIMS: HIV-infected persons with substance use disorders are least likely to benefit from advances in HIV treatment. Integration of extended-release naltrexone (XR-NTX) into HIV clinics may increase engagement in the HIV care continuum by decreasing substance use. We aimed to compare 1) XR-NTX treatment initiation, 2) retention, and 3) safety of XR-NTX versus treatment as usual (TAU) for treating opioid use disorder (OUD) and/or alcohol use disorder (AUD) in HIV clinics...
January 6, 2017: Addiction
https://www.readbyqxmd.com/read/28056726/community-mapping-of-sex-work-criminalization-and-violence-impacts-on-hiv-treatment-interruptions-among-marginalized-women-living-with-hiv-in-vancouver-canada
#8
Shira M Goldenberg, Kathleen Deering, Ofer Amram, Silvia Guillemi, Paul Nguyen, Julio Montaner, Kate Shannon
Despite the high HIV burden faced by sex workers, data on access and retention in antiretroviral therapy (ART) are limited. Using an innovative spatial epidemiological approach, we explored how the social geography of sex work criminalization and violence impacts HIV treatment interruptions among sex workers living with HIV in Vancouver over a 3.5-year period. Drawing upon data from a community-based cohort (AESHA, 2010-2013) and linked external administrative data on ART dispensation, GIS mapping and multivariable logistic regression with generalized estimating equations to prospectively examine the effects of spatial criminalization and violence near women's places of residence on 2-day ART interruptions...
January 1, 2017: International Journal of STD & AIDS
https://www.readbyqxmd.com/read/28054644/the-effectiveness-of-pressure-therapy-15-25%C3%A2-mmhg-for-hypertrophic-burn-scars-a-systematic-review-and-meta-analysis
#9
Jin-Wei Ai, Jiang-Tao Liu, Sheng-Duo Pei, Yu Liu, De-Sheng Li, Hong-Ming Lin, Bin Pei
Although pressure therapy (PT) represents the standard care for prevention and treatment of hypertrophic scar (HS) from burns, its practice is largely based on empirical evidence and its effectiveness remains controversial. To clarify the effect of PT (15-25 mmHg) for HS, we performed the systematic review and meta-analysis. Several electronic databases were screened to identify related randomized controlled trials (RCTs). 12 RCTs involving 710 patients with 761 HS resulting from burn injuries were included...
January 5, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28054414/non-coding-variation-the-2016-annual-scientific-meeting-of-the-human-genome-variation-society
#10
William S Oetting, Christophe Béroud, Steven E Brenner, Marc Greenblatt, Rachel Karchin, Sean D Mooney, Shamir Sunyaev
Significant advances have been made in recent years in the assessment and interpretation of the non-coding DNA that comprises 98% of our genome. Studying non-coding variants helps us better understand gene regulation and expression, non-coding RNA, and other non-coding genome functions. The 2016 annual scientific meeting of the Human Genome Variation Society (HGVS; http://www.hgvs.org) was held on the 18(th) of October in Vancouver, British Colombia, Canada, on the topic of "Non-Coding Variation". By using multiple data sets and wide-ranging methods including in vitro assays, high-throughput functional assays, statistical, machine learning, and other computational analyses, important sequence motifs, and the effect of variants in these regions, are being better understood...
January 5, 2017: Human Mutation
https://www.readbyqxmd.com/read/28050153/cancer-referral-and-treatment-activity-2010-2015-a-population-based-study-from-vancouver-island
#11
P Savage, C Holloway, G Lindsay, K Shubrook, C Jones, M Fung, K Schaff, H Anderson, K Nystedt, J Rauw
INTRODUCTION: The years since 2005 have seen major changes in cancer treatment and significant increases in the number of anticancer drugs available. However, there are relatively few published data to reflect how those changes are affecting the activity and workload of oncology services. To explore the effects of those changes, we reviewed the population-based cancer treatment activity on Vancouver Island for the period 2010-2015. METHODS: Information about new patient referrals, radiation courses, new chemotherapy cycles commenced, total intravenous (IV) chemotherapy treatment visits, and pharmacy activity for oral anticancer drug prescriptions was obtained from BC Cancer Agency databases...
December 2016: Current Oncology
https://www.readbyqxmd.com/read/28043735/a-prospective-intra-individual-evaluation-of-silk-combared-to-biobrane-for-the-treatment-of-superficial-burns-of-the-hand-and-face
#12
Jennifer Lynn Schiefer, Elena Arens, Daniel Grigutsch, Rebekka Rath, Alexandra Hoffmann, Paul Christian Fuchs, Alexandra Schulz
INTRODUCTION: An ever-increasing number of commercially available dressings have been applied to treat superficial burns with the aim to reduce pain and inflammation and lead to a fast wound healing and scar reduction. Nevertheless the search for cheap and effective wound dressing proceeds. Dressilk(®) consisting of silkworm silk showed good results for wound healing in regards to scarring, biocompatibility and reduction of inflammation and pain. Therefore it seemed to be an interesting product for the treatment of superficial burns...
December 30, 2016: Burns: Journal of the International Society for Burn Injuries
https://www.readbyqxmd.com/read/28041747/autologous-fat-grafting-does-not-improve-burn-scar-appearance-a-prospective-randomized-double-blinded-placebo-controlled-pilot-study
#13
Shaili Gal, Jesus Ignacio Ramirez, Pirko Maguina
OBJECTIVE: It has been proposed that fat grafts can improve the appearance of mature burn scars. The pluripotent progenitor cells contained within autologous adipose tissue grafts are believed to induce skin repair and improve scar appearance. We conducted a prospective, randomized, double-blinded, placebo-controlled study to evaluate the effects of fat grafts on the appearance of mature burn scars. METHODS: Pediatric burn survivors with mature scars were recruited for this study...
December 29, 2016: Burns: Journal of the International Society for Burn Injuries
https://www.readbyqxmd.com/read/28035662/evaluation-of-accuracy-and-precision-in-polymer-gel-dosimetry
#14
Evan Maynard, Michelle Hilts, Emily Heath, Andrew Jirasek
PURPOSE: To assess the overall reproducibility and accuracy of an x-ray computed tomography (CT) polymer gel dosimetry (PGD) system and investigate what effects the use of generic, inter-batch, and intra-batch gel calibration have on dosimetric and spatial accuracy. METHODS: A N-isopropylacrylamide (NIPAM) based gel formulation optimized for x-ray CT gel dosimetry was used and the results over four different batches of gels were analyzed. All gels were irradiated with three 6 MV beams in a calibration pattern at both the bottom and top of the dosimeter...
December 30, 2016: Medical Physics
https://www.readbyqxmd.com/read/28034668/modified-vancouver-scar-scale-score-is-linked-with-quality-of-life-after-burn
#15
Vidya Finlay, Sally Burrows, Rosemary Kendell, Aaron Berghuber, Vincent Chong, Jason Tan, Dale W Edgar, Fiona Wood
INTRODUCTION: This study aimed to determine if a scar quality is associated with quality of life (QoL) at six months post-burn and beyond. METHODS: Quantile regression models adjusted for covariates were used to demonstrate the relationship of modified Vancouver Scar Scale (mVSS) total (with and without pigmentation) and the mVSS components, to the Burn Specific Health Scale-Brief (BSHS-B) scores (full scale, Affect and Relations domain, Skin Sensitivity domain)...
December 26, 2016: Burns: Journal of the International Society for Burn Injuries
https://www.readbyqxmd.com/read/28033142/sbirt-screening-brief-intervention-and-referral-to-treatment-among-trauma-patients-a-review-of-the-inpatient-process-and-patient-experience
#16
Erin K Gormican, Zahra S Hussein
Screening, brief intervention, and referral to treatment (SBIRT) is an important and effective strategy among injury prevention measures aimed at reducing risky alcohol use (). The trauma patient population is at significant risk for alcohol-related trauma recidivism () and is therefore a priority group in which to implement SBIRT. Vancouver General Hospital (VGH) implemented SBIRT on its 2 inpatient trauma units in the fall of 2014. The alcohol use disorders screening test (AUDIT-C) was chosen as the screening tool for nurses to complete with new patients...
January 2017: Journal of Trauma Nursing: the Official Journal of the Society of Trauma Nurses
https://www.readbyqxmd.com/read/28031950/improving-public-awareness-and-outcomes-for-oral-cancer
#17
Catherine F Poh
Catherine Poh speaks to G Westcott, Commissioning Editor: Dr. C Poh gained a dental degree from the National Taiwan University in Taipei, Taiwan and went on to gain her PhD from the University of British Columbia in 1997, looking into molecular biology in oral cancer. In addition to her current role an associate professor in the Faculty of Dentistry at the University of British Columbia, she is a senior clinician scientist at the Integrative Oncology Department of the BC Cancer Agency's Research Centre. She has various other roles, including being active within the Oral Oncology Department at BC Cancer Agency and the Oral Mucosal Disease Program at Vancouver General Hospital...
March 2016: Future Science OA
https://www.readbyqxmd.com/read/28028474/cretaceous-origin-of-dogwoods-an-anatomically-preserved-cornus-cornaceae-fruit-from-the-campanian-of-vancouver-island
#18
Brian A Atkinson, Ruth A Stockey, Gar W Rothwell
BACKGROUND: Cornaceae consists of 58 species, all within the genus Cornus. The Cenozoic record of Cornus is extensive and well documented. Molecular divergence-time studies suggest that crown-group Cornus may have originated by the Late Cretaceous. However, there has been no formal report of Cornus from Cretaceous deposits. Here, we characterize a permineralized fossil fruit assignable to Cornus subg. Cornus from the Upper Cretaceous (Campanian) Shelter Point locality of Vancouver Island, British Columbia, Canada...
2016: PeerJ
https://www.readbyqxmd.com/read/28027990/dual-sexual-and-drug-related-predictors-of-hepatitis-c-incidence-among-sex-workers-in-a-canadian-setting-gaps-and-opportunities-for-scale-up-of-hcv-prevention-treatment-and-care
#19
Shira M Goldenberg, Julio Montaner, Melissa Braschel, Eugenia Socias, Silvia Guillemi, Kate Shannon
BACKGROUND: Hepatitis C virus (HCV) represents a significant cause of morbidity and mortality globally. While sex workers (SWs) may face elevated HCV risks through both drug/sexual pathways, incidence data among SWs are severely lacking. We characterized HCV incidence and predictors of HCV seroconversion among women SWs in Vancouver, BC. METHODS: Questionnaire and serological data were drawn from a community-based cohort of women SWs (2010-2014). Kaplan-Meier METHODS: and Cox regression were used to model HCV incidence and predictors of time to HCV seroconversion...
December 24, 2016: International Journal of Infectious Diseases: IJID
https://www.readbyqxmd.com/read/28026733/long-term-function-following-periprosthetic-fractures
#20
J Zwingmann, M Krieg, F Thielemann, N Südkamp, P Helwig
PURPOSE OF THE STUDY Clinical results of long-term follow-up after traumatic periprosthetic femur fractures and different therapies (ORIF vs. revision arthroplasty) MATERIAL AND METHODS The Visual Analog Scale (VAS), Harris-Hip-Score (HHS), Oxford-Hip-Score (OHS), Oxford-Knee-Score (OKS), Knee-Society-Score (KSS), SF-36 Questionnaire and Funktionsfragebogen Hannover (FFH) were used to evaluate outcome and functionality. Radiological examinations were performed and the Vancouver (THA) and Lewis and Rorabeck (TKA) classifications used...
2016: Acta Chirurgiae Orthopaedicae et Traumatologiae Cechoslovaca
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