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https://www.readbyqxmd.com/read/28714381/gemcitabine-associated-pseudocellulitis-a-missed-diagnosis
#1
Dalvir Gill, Josh Schrader, Matthew Kelly, Fidel Martinez, Wajihuddin Syed, Jonathan Wright
We report a case of a 51-year-old male with past medical history significant for cholangiocarcinoma presented with two weeks of worsening bilateral lower extremity swelling and erythema. Patient has been on active chemotherapy for his cholangiocarcinoma with Gemcitabine weekly infusions. Physical exam was significant for bilaterally petechial rash coalescing into ecchymoses over the dorsum of the feet, sparing soles and toes, which dissipated into thinning petechiae more proximally. On labs he did not have any leukocytosis, his platelet count was 50 × 10(3)/µL and basic metabolic panel was benign...
January 1, 2017: Journal of Oncology Pharmacy Practice
https://www.readbyqxmd.com/read/28712817/clinical-features-and-dynamic-ordinary-laboratory-tests-differentiating-dengue-fever-from-other-febrile-illnesses-in-children
#2
Chih-Ho Chen, Yi-Chuan Huang, Kuang-Che Kuo, Chung-Chen Li
BACKGROUND: Dengue fever is not easily to be diagnosed before presentation of the classic symptoms. The study aimed to investigate the clinical features and dynamic laboratory tests in pediatric patients to facilitate dengue diagnosis. METHODS: This retrospective study examined the medical records of all pediatric patients who were clinically suspected to have dengue from June to December 2014. Laboratory-positive dengue cases were confirmed by detecting non-structural protein NS1, reverse transcription-polymerase chain reaction of dengue virus, and dengue-specific IgM seroconversion...
June 30, 2017: Journal of Microbiology, Immunology, and Infection, Wei Mian Yu Gan Ran za Zhi
https://www.readbyqxmd.com/read/28686752/leukocytoclastic-vasculitis-resolution-with-topical-dapsone
#3
David A Pate, Luke S Johnson, Michelle B Tarbox
Leukocytoclastic vasculitis (LCV) is a disease characterized by inflammation of small vessels presenting with petechiae and palpable purpura. Leukocytoclastic vasculitis often spontaneously resolves within weeks and requires only symptomatic treatment. Chronic or severe disease can require systemic treatment with agents such as colchicine, dapsone, or corticosteroids, which are effective but carry a risk for serious adverse events. These side effects and/or medical contraindications preclude some patients from taking systemic medications for LCV...
June 2017: Cutis; Cutaneous Medicine for the Practitioner
https://www.readbyqxmd.com/read/28682146/treatment-of-caf%C3%A3-au-lait-macules-with-a-high-fluenced-1-064-nm-q-switched-neodymium-yttrium-aluminum-garnet-laser
#4
Jiehoon Kim, Hoon Hur, Yu Ri Kim, Sung Bin Cho
Café-au-lait macules (CALMs) are light to dark brown macules or patches of increased melanin concentration found along the dermoepidermal junction. Although many attempts to treat CALMs using various kinds of laser/light-based devices have been reported, CALMs remain refractory thereto with high recurrence rates. In this case series, we describe four patients with idiopathic CALMs that were effectively and safely treated with a non-ablative, high-fluenced, Q-switched (QS), 1,064-nm neodymium:yttrium aluminum garnet (Nd:YAG) laser...
July 6, 2017: Journal of Cosmetic and Laser Therapy: Official Publication of the European Society for Laser Dermatology
https://www.readbyqxmd.com/read/28650987/accuracy-of-zika-virus-disease-case-definition-during-simultaneous-dengue-and-chikungunya-epidemics
#5
José Ueleres Braga, Clarisse Bressan, Ana Paula Razal Dalvi, Guilherme Amaral Calvet, Regina Paiva Daumas, Nadia Rodrigues, Mayumi Wakimoto, Rita Maria Ribeiro Nogueira, Karin Nielsen-Saines, Carlos Brito, Ana Maria Bispo de Filippis, Patrícia Brasil
BACKGROUND: Zika is a new disease in the American continent and its surveillance is of utmost importance, especially because of its ability to cause neurological manifestations as Guillain-Barré syndrome and serious congenital malformations through vertical transmission. The detection of suspected cases by the surveillance system depends on the case definition adopted. As the laboratory diagnosis of Zika infection still relies on the use of expensive and complex molecular techniques with low sensitivity due to a narrow window of detection, most suspected cases are not confirmed by laboratory tests, mainly reserved for pregnant women and newborns...
2017: PloS One
https://www.readbyqxmd.com/read/28649563/symptomatic-congenital-cytomegalovirus-infection-in-children-of-seropositive-women
#6
Ines Mack, Marie-Anne Burckhardt, Ulrich Heininger, Friederike Prüfer, Sven Schulzke, Sven Wellmann
Cytomegalovirus (CMV) is the most frequent congenital virus infection worldwide. The risk of congenital CMV (cCMV) transmission is highest in seronegative women who acquire primary CMV infection during pregnancy. A growing body of evidence indicates that secondary CMV infections in pregnant women with preconceptual immunity (either through reactivation of latent virus or re-infection with a new strain of CMV) contribute to a much greater proportion of symptomatic cCMV than was previously thought. Here, we describe a case of symptomatic cCMV infection in the newborn of a woman with proven immunity prior to pregnancy...
2017: Frontiers in Pediatrics
https://www.readbyqxmd.com/read/28598047/awareness-and-outcome-of-changing-trends-in-clinical-profile-of-dengue-fever-a-retrospective-analysis-of-dengue-epidemic-from-january-to-december-2014-at-a-tertiary-care-hospital
#7
Jitendra Singh, Anju Dinkar, Virendra Atam, D Himanshu, Kamlesh Kumar Gupta, Kauser Usman, Ravi Misra
BACKGROUND: Dengue fever is caused by mosquito-borne arboviral infection that has become a public health concern globally. Recently, an alarming rise of dengue has also been seen in India. Hence the study was undertaken to know profile of clinical manifestations and laboratory findings during the evolution of dengue fever. METHODS: In this study, retrospective data analysis was done in 216 seropositive dengue patients admitted between January to December 2014 in department of medicine at a north Indian care hospital...
May 2017: Journal of the Association of Physicians of India
https://www.readbyqxmd.com/read/28565737/-a-study-on-the-establishment-of-immune-thrombocytopenia-model-induced-by-anti-platelet-gp%C3%A2-b%C3%AE-antibodies
#8
K X Zhou, R Yan, M X Chen, J Liu, Q Y Cui, R P Hu, Y C Liu, Y Zhang, C G Ruan, K S Dai
Objective: To establish primary immune thrombocytopenia (ITP) animal model induced by anti-platelet membrane glycoprotein GPⅠbα antibodies AN51 and R300. Methods: Twenty guinea pigs (6-8 week) were divided into 4 groups. Five guinea pigs in each group were intravenously injected with different doses of AN51 (0.05, 0.1, 0.2 μg/g) and 0.2 μg/g IgG as control. The whole blood was collected from inner angular venous plexus. Platelets number was determined by an automated cell counter and Swiss-Jim method. Then, the similar protocol was used to establish ITP nude mice model by intraperitoneal injection of different concentrations of anti-platelet GPⅠbα antibody R300, respectively...
May 14, 2017: Zhonghua Xue Ye Xue za Zhi, Zhonghua Xueyexue Zazhi
https://www.readbyqxmd.com/read/28561632/-traumatic-asphyxia-with-permanent-visual-loss-case-report
#9
Tibor Kántor, Bianca Grigorescu, Gabriel Popescu, Attila Ferencz, Örs Nagy, János Jung, István Gergely
Traumatic asphyxia is a rare condition that occurs after compressive thoracoabdominal trauma, which is characterized by subconjunctival hemorrhage, cervicofacial cyanosis, edema and petechiae. Serious life-threatening thoracic and abdominal injuries may coexist. After conservatory treatment in most cases complete recovery is achieved, but in isolated cases permanent neurological lesions may occur. We present the case of the 39-year-old male patient who suffered a compressive thoracoabdominal trauma. The physical examination showed the characteristic "ecchymotic mask"...
June 2017: Orvosi Hetilap
https://www.readbyqxmd.com/read/28557844/child-deaths-of-undetermined-intent-an-analysis-of-circumstances-using-illinois-violent-death-reporting-system-data
#10
Han-Wei Wu, Suzanne G McLone, Maryann Mason, Karen Sheehan
BACKGROUND: There is little information available about the circumstances surrounding the deaths of children aged 0 to 14 in which the manner of death is of undetermined intent. METHODS: We analyzed data collected in the Illinois Violent Death Reporting System (IVDRS) to describe victim demographics, location of injury, seasonality, day of week, and circumstances surrounding the victims' deaths. RESULTS: From 2005 to 2010 in Cook County, Illinois, 192 cases were identified of children aged 0-14 years, in which the manner of death was of undetermined intent...
May 25, 2017: Journal of Trauma and Acute Care Surgery
https://www.readbyqxmd.com/read/28537561/prediction-of-acute-pancreatitis-in-the-earliest-stages-role-of-biochemical-parameters-and-histopathological-changes
#11
Jacek Baj, Elżbieta Radzikowska, Marcin Maciejewski, Andrzej Dąbrowski, Kamil Torres
For many years, there has been a search for a set of biochemical parameters that could facilitate the assessment of severity, prognosis, and administration of early and appropriate treatment in acute pancreatitis. Administration of treatment within the first 48 hours since admission is associated with many problems of distinguishing patients with a mild form of acute pancreatitis (AP) from those with a severe form of acute pancreatitis. STUDY AIM: To assess the relationship between the extent of change in the concentration of 10 selected biochemical indicators: amylase, lipase, total bilirubin, creatinine, uric acid, aspartate transaminase, alanine transaminase, glucose, magnesium, and iron and histopathological lesions in the pancreas within 2 and 6 hours since induction of AP...
April 30, 2017: Polski Przeglad Chirurgiczny
https://www.readbyqxmd.com/read/28518476/adult-onset-chronic-cyclic-thrombocytopenia-in-a-rhesus-macaque-macaca-mulatta-after-dengue-virus-vaccination-and-viral-challenge
#12
Galit H Frydman, Kelly A Metcalf Pate, Robert P Marini, Armelle M de Laforcade, Irene Bosch, Vasudevan Bakthavatchalu, Sureshkumar Muthupalani, Alton G Swennes, Claire E Lyons, Ronald G Tompkins, James G Fox
An 8-year-old, male Rhesus macaque (Macaca mulatta), previously used for dengue virus (DENV) vaccine research with viral challenge, was presented with adult-onset, chronic, cyclic thrombocytopenia. Platelet number, morphology, and function were evaluated by automated hematology, peripheral blood smears, electron microscopy, flow cytometry, and impedance aggregometry. Bone marrow was evaluated by cytology. Both serum anti-dengue nonstructural protein 1 (NS1) antibodies and anti-platelet antibodies were detected by ELISA...
June 2017: Veterinary Clinical Pathology
https://www.readbyqxmd.com/read/28471126/multiple-myeloma-with-an-unusual-oral-presentation
#13
REVIEW
Anjali Nayak, Meghanand T Nayak
Multiple myeloma (MM) is a dyscrasia caused by neoplastic proliferation of somatically mutated plasma cells. Myeloma cells divide and expand within the bone marrow affecting multiple locations in the body where bone marrow is present. Oral manifestations, though common are usually not diagnosed. This report describes rare oral manifestations of multiple myeloma like oral petechiae and gingival swelling presented in a 40-year-old male patient. The diagnosis was established by blood examination & skeletal survey, while oral findings were later correlated with the diagnosis of MM...
July 2016: Journal of Experimental Therapeutics & Oncology
https://www.readbyqxmd.com/read/28460413/laparoscopic-evaluation-of-the-small-intestine-in-the-standing-horse-technique-and-effects
#14
Andrew R E Jones, Claude A Ragle, Dusty Anderson, Coryelle Scott
OBJECTIVE: To evaluate the feasibility and clinical outcomes after laparoscopic evaluation of the small intestines via laparoscopy. STUDY DESIGN: Prospective pilot study. ANIMALS: Healthy adult horses (n = 5). METHODS: Horses were restrained in standing stocks and received an infusion of detomidine. One port was placed in the left last intercostal space and 3 ports were placed in the right paralumbar fossa. The small intestine was run with atraumatic laparoscopic grasping forceps, from the duodenocolic plica to the ileocecal plica...
April 29, 2017: Veterinary Surgery: VS
https://www.readbyqxmd.com/read/28459894/fever-petechiae-and-joint-pain
#15
Syed Rahman, Adetunji Adegboyega, Kate Rowland
Our patient's signs and symptoms developed one week after being bitten by a rat that she was feeding to her son's pet snake.
May 2017: Journal of Family Practice
https://www.readbyqxmd.com/read/28441232/atriobronchial-fistula-complicated-by-septic-cerebral-air-emboli-after-pulmonary-vein-ablation
#16
David Velghe, Thomas Apers, Stefanie Devriendt, Ivo Deblier, Bart Hendriks, Rogier Nieuwendijk, Peter Rogiers
OBJECTIVE: To describe a case of an infected atriobronchial fistula as a late complication after pulmonary vein ablation, leading to septic air emboli and requiring urgent cardiac surgery. DATA SOURCES: Clinical observation. STUDY SELECTION: Case report. DATA EXTRACTION: Relevant clinical information. PubMed was searched for relevant literature. DATA SYNTHESIS: Given its high success and low complication rate, pulmonary vein isolation is expected to be increasingly performed worldwide...
August 2017: Critical Care Medicine
https://www.readbyqxmd.com/read/28420931/paediatrics-primary-myelofibrosis-and-acute-stroke-a-rare-presentation
#17
Wajida Mazher, Ather Hasan Rizvi, Arsalan Majeed Adam, Muhammad Saad Ali Mallick, Ansab Godil
Idiopathic Myelofibrosis is a rare myeloproliferative disorder. In children, it becomes even rarer. Herein, we report a case of idiopathic myelofibrosis of a 6-year old male patient who presented with complaints of pallor, petechiae and bleeding from gums. Bone marrow aspirate showed afragmented haemodiluted smears with erythroid and myeloid precursors scattered throughout. Trephine biopsy showed increased background fibrotic activity along with clusters of histiocytes. A diagnosis of paediatric primary myelofibrosis was made on biopsy...
April 2017: JPMA. the Journal of the Pakistan Medical Association
https://www.readbyqxmd.com/read/28413059/viral-exanthems-an-update-on-laboratory-testing-of-the-adult-patient
#18
REVIEW
Abraham M Korman, Ali Alikhan, Benjamin H Kaffenberger
Although classic viral exanthems of childhood are well described, they are rarely differentiated in adults. Laboratory techniques for viral identification have advanced without substantial literature to suggest how a dermatologist ought to conduct a cost-effective and diagnostic viral panel. Certain clinical features such as petechiae, vesicles, and dusky macular or morbilliform exanthems point strongly toward a viral exanthem. Differentiation of drug and viral causes of morbilliform eruptions has proven difficult...
March 2017: Journal of the American Academy of Dermatology
https://www.readbyqxmd.com/read/28398413/imatinib-mesylate-induced-lichenoid-drug-eruption
#19
REVIEW
Erin H Penn, Hye Jin Chung, Matthew Keller
Imatinib mesylate (imatinib) is a tyrosine kinase inhibitor initially approved by the US Food and Drug Administration in 2001 for chronic myeloid leukemia (CML). Since then, the number of indicated uses for imatinib has substantially increased. It is increasingly important that dermatologists recognize adverse cutaneous manifestations of imatinib and are aware of their management and outcomes to avoid unnecessarily discontinuing a potentially lifesaving medication. Adverse cutaneous manifestations in response to imat-inib are not infrequent and can include dry skin, alopecia, facial edema, and photosensitivity rash...
March 2017: Cutis; Cutaneous Medicine for the Practitioner
https://www.readbyqxmd.com/read/28387528/palatal-petechiae-in-the-absence-of-group-a-streptococcus-in-pediatric-patients-with-acute-onset-neuropsychiatric-deterioration-a-cohort-study
#20
Talia Mahony, Douglas Sidell, Hayley Gans, Michael Cooperstock, Kayla Brown, Joanne M Cheung, Bahare Farhadian, Melissa Gustafson, Margo Thienemann, Jennifer Frankovich
BACKGROUND: Palatal petechiae are 95% specific for streptococcal pharyngitis. Despite this, and despite prior research demonstrating that Group A Streptococcus (GAS) is a common antecedent to pediatric acute-onset neuropsychiatric syndrome (PANS) episodes, we anecdotally observed a low rate of documented GAS in patients with PANS and palatal petechiae. This retrospective chart review was conducted to formally report the rate of palatal petechiae and concurrent GAS in a cohort of patients with PANS and investigate other etiologic factors...
April 7, 2017: Journal of Child and Adolescent Psychopharmacology
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