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https://www.readbyqxmd.com/read/28060677/pathogenesis-of-frog-virus-3-ranavirus-iridoviridae-infection-in-wood-frogs-rana-sylvatica
#1
M J Forzán, K M Jones, E Ariel, R J Whittington, J Wood, R J Frederick Markham, P-Y Daoust
Wood frogs ( Rana sylvatica) are highly susceptible to infection with Frog virus 3 (FV3, Ranavirus, Iridoviridae), a cause of mass mortality in wild populations. To elucidate the pathogenesis of FV3 infection in wood frogs, 40 wild-caught adults were acclimated to captivity, inoculated orally with a fatal dose of 10(4.43) pfu/frog, and euthanized at 0.25, 0.5, 1, 2, 4, 9, and 14 days postinfection (dpi). Mild lesions occurred sporadically in the skin (petechiae) and bone marrow (necrosis) during the first 2 dpi...
January 1, 2017: Veterinary Pathology
https://www.readbyqxmd.com/read/28052946/dabigatran-related-leukocytoclastic-vasculitis
#2
Josiah An, Rohan Garje, Karolyn A Wanat, José Pablo Leone
Dabigatran is a non-vitamin K antagonist oral anticoagulant that has been approved for atrial fibrillation and prevention of venous thromboembolism. Its use has been increasing in the USA since serum drug levels do not need monitoring. To date, no significant skin side effects have been reported other than 4 cases of non-specific skin lesion and 2 cases of leukocytoclastic vasculitis (LCV), which is a small vessel inflammatory disease that presents as palpable purpura in lower extremities. We present a man aged 57 years with chronic deep vein thrombosis who developed palpable purpura, petechiae, swelling in lower extremities, torso and distal upper extremities on the third day after dabigatran initiation...
January 4, 2017: BMJ Case Reports
https://www.readbyqxmd.com/read/28029716/inactivation-of-human-coagulation-factor-x-by-a-protease-of-the-pathogen-capnocytophaga-canimorsus
#3
K Hack, F Renzi, E Hess, F Lauber, J Douxfils, J M Dogné, G R Cornelis
BACKGROUND: Capnocytophaga canimorsus is a Gram-negative bacterium, which belongs to the oral flora of dogs and causes fulminant sepsis in humans who have been bitten, licked or scratched. In patients, bleeding abnormalities, such as petechiae, purpura fulminans or disseminated intravascular coagulation (DIC) occur frequently. OBJECTIVE: We investigated whether C. canimorsus could actively contribute to these bleeding abnormalities. METHODS: Calibrated automated thrombogram and clotting time assays were performed to assess the anticoagulant activity of C...
December 28, 2016: Journal of Thrombosis and Haemostasis: JTH
https://www.readbyqxmd.com/read/28012128/death-of-a-seven-month-old-child-in-a-washing-machine-a-case-report
#4
Antonio Osculati, Silvia Damiana Visonà, Laura Re, Marta Sozzi, Francesca Castelli, Luisa Andrello, Claudia Vignali
The authors present a case which brings out a unique modality of child homicide by placing the baby in a washing machine and turning it on. The murder was perpetrated by the baby's mother, who suffered from a serious depressive disorder. A postmortem RX and then a forensic autopsy were performed, followed by histologic examinations and toxicology. On the basis of the results of the autopsy, as well as the histology and the negative toxicological data, the cause of death was identified as acute asphyxia. This diagnosis was rendered in light of the absence of other causes of death, as well as the presence of typical signs of asphyxia, such as epicardial and pleural petechiae and, above all, the microscopic examinations, which pointed out a massive acute pulmonary emphysema...
December 24, 2016: International Journal of Legal Medicine
https://www.readbyqxmd.com/read/27987519/-autoimmune-disorder-secondary-to-digeorge-syndrome-a-long-term-follow-up-case-report-and-literature-review
#5
Y Xie, J Q Guo, Y Hua, W H Zhao, Q Sun, X T Lu
DiGeorge syndrome is the most common chromosome microdeletion disease. The classical complications include congenital heart disease, hypothyroidism, immunodeficiency, facial abnormalities, and hypocalcemia. According to whether there is an absence or hypoplasia of the thymus, DiGeorge syndrome can be divided into two types, complete DiGeorge syndrome and partial DiGeorge syndrome. The patient was a female born with congenital heart disease, facial abnormalities and cleft palate. When the patient went to school, she had learning difficulty and had problems in communication and personal social behavior...
December 18, 2016: Beijing da Xue Xue Bao. Yi Xue Ban, Journal of Peking University. Health Sciences
https://www.readbyqxmd.com/read/27938815/acrally-distributed-dermatoses-vascular-dermatoses-purpura-and-vasculitis
#6
Jana Kazandjieva, Dimitar Antonov, Jivko Kamarashev, Nikolai Tsankov
Purpuric lesions appear in acral distribution in a variety of conditions and often provide clues to the clinical diagnosis. Purpuric means "hemorrhagic"-that is, the lesions do not blanch from pressure. This review focuses on dermatoses that produce hemorrhagic lesions in acral distribution from the large groups of the vasculitic diseases and their mimics. Cutaneous small vessel vasculitis is confined to the skin, involves mainly postcapillary venules, and has the hallmark manifestation of palpable purpura...
January 2017: Clinics in Dermatology
https://www.readbyqxmd.com/read/27891382/a-case-of-immune-thrombocytopenic-purpura-secondary-to-pulmonary-tuberculosis
#7
Sameer Panda, Lalit Kumar Meher, Siba Prasad Dalai, Sachidananda Nayak, Sujit Kumar Tripathy
The haematological abnormalities associated with active pulmonary tuberculosis were known to human beings since decades but Immune Thrombocytopenic Purpura (ITP) secondary to pulmonary tuberculosis have been reported only in a couple of instances. We report a 27 year-old male patient who was admitted to our hospital with fever, shortness of breath, haematuria, epistaxis and generalized petechiae. The sputum positivity for Acid Fast Bacilli (AFB) and chest X-ray reports were suggestive of active pulmonary tuberculosis in our patient...
October 2016: Journal of Clinical and Diagnostic Research: JCDR
https://www.readbyqxmd.com/read/27889737/immune-thrombocytopenic-purpura-in-children-of-eastern-henan-province-china
#8
Qiu-Xia Fan, Chun-Mei Wang, Shu-Xia Chen, Xin-Guang Liu, Bo Han
In this retrospective cohort study conducted in 63 children with idiopathic thrombocytopenic purpura (ITP) in China; petechiae, bruises and bleeding were the major presentations. Most cases required therapy with one/more treatment options.
November 15, 2016: Indian Pediatrics
https://www.readbyqxmd.com/read/27878586/-parainfectious-optic-neuritis-with-macular-infiltrate-in-neisseria-meningitidis-b-meningitis
#9
A Chronopoulos, F Hoogewoud, H Steffen, G Thumann
OBJECTIVE: We report on the case of a young immunocompetent female patient with parainfectious optic neuritis and macular inflitrate due to Neisseria meningitidis B meningitis. METHOD: Case report RESULTS: A 22-year-old female patient was admitted to the emergency department for intensive care treatment with a strong suspicion of meningitis. Clinical and serological parameters were indicative of a bacterial genesis of the meningitis. By analysis of the cerebrospinal fluid (CSF) Neisseria meningitidis type B could be detected...
November 23, 2016: Der Ophthalmologe: Zeitschrift der Deutschen Ophthalmologischen Gesellschaft
https://www.readbyqxmd.com/read/27876005/a-predictive-model-to-differentiate-dengue-from-other-febrile-illness
#10
Eduardo Fernández, Marek Smieja, Stephen D Walter, Mark Loeb
BACKGROUND: Dengue is a major public health problem in tropical and subtropical countries and has a presentation similar to other febrile illnesses. Since laboratory confirmation is frequently delayed, the majority of dengue cases are diagnosed based on symptoms. The objective of this study was to identify clinical, hematological and demographical parameters that could be used as predictors of dengue fever among patients with febrile illness. METHODS: We conducted a retrospective cohort study of 548 patients presenting with febrile syndrome to the largest public hospitals in Honduras...
November 22, 2016: BMC Infectious Diseases
https://www.readbyqxmd.com/read/27872729/mild-bleeders-diagnosis-is-elusive-in-large-number-of-patients
#11
Mrinalini Kotru, Deepti Mutereja, Abhishek Purohit, Seema Tyagi, Manoranjan Mahapatra, Renu Saxena, Hara Prasad Pati
BACKGROUND: Bleeding is a common clinical presentation. Even patients with mild bleeding disorders are extensively investigated for ascertaining the cause. The present study was conducted in order to evaluate the extent of the possibility of diagnosis in mild bleeding disorders. MATERIAL AND METHODS: This was a prospective study of patients referred for work up of mild bleeding for a period of 13 months. A complete blood count, peripheral smear examination, Prothrombin time, Partial Thromboplastin time and Thrombin Time, Platelet Aggregometry test, tests for von Willebrand's disease and Platelet Factor 3 availability were measured...
2016: Mediterranean Journal of Hematology and Infectious Diseases
https://www.readbyqxmd.com/read/27870800/postoperative-inner-nuclear-layer-microcysts-affecting-long-term-visual-outcomes-after-epiretinal-membrane-surgery
#12
Shih-Jen Chen, Fang-Yi Tsai, Han-Chung Liu, Yu-Chien Chung, Tai-Chi Lin
PURPOSE: To investigate the risk factors and long-term visual impact of microcysts in the inner nuclear layer developed after epiretinal membrane (ERM) surgery. METHODS: This study used a retrospective review of medical records, operative video and images of patients who had undergone idiopathic ERM surgery with more than 12 months of follow-up. RESULTS: This study enrolled 44 patients (44 eyes) with ERM and a mean follow-up period of 30.2 months...
December 2016: Retina
https://www.readbyqxmd.com/read/27859562/vitamin%C3%A2-c-deficiency-and-diabetes-mellitus-easily-missed
#13
D J Christie-David, J E Gunton
Scurvy and vitamin C deficiency are usually considered to be of only historical interest. Interestingly, most animals can synthesize vitamin C, but not humans, higher primates, guinea-pigs and some bats. Deficiency results in the defective formation of collagen and connective tissues; symptoms of deficiency may include bruising, bleeding gums, petechiae, arthralgia and impaired wound healing [1,2]. This article is protected by copyright. All rights reserved.
November 18, 2016: Diabetic Medicine: a Journal of the British Diabetic Association
https://www.readbyqxmd.com/read/27805246/bovine-neonatal-pancytopenia-correlation-between-clinical-symptoms-hematological-parameters-and-lifespan
#14
Marek Gehrke, Vivian Junge, Jędrzej M Jaśkowski, Mirosław P Polak, Krzysztof Urbaniak, Aleksandra Żuraw
OBJECTIVE: To compare the hematological parameters and clinical symptoms between Bovine Neonatal Pancytopenia (BNP) diseased calves dying before and after 14 days of life. MATERIAL AND METHODS: Clinical observations included 47 calves from dams which underwent a 3-year vaccination program with the inactivated PregSure(®) BVD vaccine. In 25 of these 47 BNP affected calves blood examinations were performed and in 22 dead calves diagnosis was mainly based on post-mortem findings...
December 5, 2016: Tierärztliche Praxis. Ausgabe G, Grosstiere/Nutztiere
https://www.readbyqxmd.com/read/27789160/-perthes-syndrome-secondary-to-an-asthma-attack-a-case-report-in-a-15-year-old-child
#15
W El Amraoui, A El Koraichi, A Bentalha, S E El Kettani
Perthes syndrome, or traumatic asphyxia syndrome, is a rare clinical entity, associating cyanosis, cervicofacial petechiae and subconjunctival hemorrhage. It is usually secondary to chest trauma, but can occur in any situation of abrupt rise in intrathoracic pressure with closed glottis. In this paper, we present a case of Perthes syndrome that triggered an asthma attack for a child during surgery.
December 2016: Revue de Pneumologie Clinique
https://www.readbyqxmd.com/read/27785715/unusual-appearance-of-facial-petechiae-and-conjunctival-hemorrhages-the-trout-phenomenon-in-a-case-of-fatal-subarachnoid-hemorrhage-due-to-ruptured-berry-aneurysm
#16
Danica Cvetković, Vladimir Živković, Slobodan Nikolić
No abstract text is available yet for this article.
December 2016: Forensic Science, Medicine, and Pathology
https://www.readbyqxmd.com/read/27784525/cutaneous-collagenous-vasculopathy-associated-benign-pigmented-purpura
#17
Warren R Heymann
A 68-year-old woman presented with an asymptomatic eruption predominantly on the proximal pretibial region of the right lower extremity, which had been present for many months. Her medical history was remarkable for diabetes and hypothyroidism. Physical examination demonstrated "cayenne pepper"-like brown macules, scattered petechiae, and multiple minute, blanching telangiectasias (Figure 1) that were more evident on dermatoscopy (Figure 2). The clinical differential diagnosis included a benign pigmented purpura (BBP; Schamberg type), telangiectasia macularis eruptiva perstans, cutaneous T-cell lymphoma, essential telangiectasia, and cutaneous collagenous vasculopathy (CCV)...
2016: Skinmed
https://www.readbyqxmd.com/read/27777430/a-case-of-streptobacillus-moniliformis-infection-with-cutaneous-leukocytoclastic-vasculitis
#18
Yoshio Kawakami, Takashi Katayama, Masayuki Kishida, Wakako Oda, Yasuro Inoue
A 71-year-old man presented with a high fever, polyarthralgia, petechiae and palpable purpura accompanied by livedoid change on his legs and feet. Histopathological findings of the purpura revealed perivascular infiltration of neutrophils, mononuclear cells, and nuclear debris, and extravasation of red cells mainly in the upper dermis: all signs consistent with leukocytoclastic vasculitis. Small vessel thrombi, which are characteristic features of septic vasculopathy, were also observed. Direct immunofluorescence showed negative results...
October 2016: Acta Medica Okayama
https://www.readbyqxmd.com/read/27771676/ethylmalonic-encephalopathy-in-an-indian-boy
#19
Sunita Bijarnia-Mahay, Deepti Gupta, Yosuke Shigematsu, Seiji Yamaguchi, Renu Saxena, I C Verma
BACKGROUND: Ethylmalonic encephalopathy is a rare inborn error of metabolism characterized by neurodevelopmental delay / regression, recurrent petechiae, orthostatic acrocyanosis, and chronic diarrhea. CASE CHARACTERISTICS: 4-year-old boy with developmental regression, chronic diarrhea, petechial spots and acrocyanosis. MRI brain showed T2W/FLAIR hyperintensities in bilateral caudate and putamen. Abnormal acyl-carnitine profile and metabolites on urinary GC-MS analysis suggested the diagnosis...
October 8, 2016: Indian Pediatrics
https://www.readbyqxmd.com/read/27766201/unusual-complication-of-bronchoscopy
#20
Darius Kang Lie Aw, Matthew Zhen Wei Tan, Anthony Chau Ang Yii, Dorothy Hui Lin Ng
In the last twenty years, the field of bronchoscopy has become increasingly more complex and invasive. It is now widely used in the management of pulmonary diseases and has the benefit of low mortality and complication rates. Overall incidence of complications and mortality reported ranges around 1% and 0.02% respectively. Common complications of bronchoscopy include pulmonary haemorrhage, desaturation, pneumothorax, and pulmonary oedema. However, facial and neck petechiae associated with subcutaneous hemorrhage post-bronchoscopy has not been reported before in the literature...
2016: Respiratory Medicine Case Reports
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