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https://www.readbyqxmd.com/read/29348825/a-novel-anti-cd146-antibody-specifically-targets-cancer-cells-by-internalizing-the-molecule
#1
Marie Nollet, Jimmy Stalin, Anaïs Moyon, Waël Traboulsi, Amel Essaadi, Stéphane Robert, Nausicaa Malissen, Richard Bachelier, Laurent Daniel, Alexandrine Foucault-Bertaud, Caroline Gaudy-Marqueste, Romaric Lacroix, Aurélie S Leroyer, Benjamin Guillet, Nathalie Bardin, Françoise Dignat-George, Marcel Blot-Chabaud
CD146 is an adhesion molecule present on many tumors (melanoma, kidney, pancreas, breast, ...). In addition, it has been shown to be expressed on vascular endothelial and smooth muscle cells. Generating an antibody able to specifically recognize CD146 in cancer cells (designated as tumor CD146), but not in normal cells, would thus be of major interest for targeting tumor CD146 without affecting the vascular system. We thus generated antibodies against the extracellular domain of the molecule produced in cancer cells and selected an antibody that specifically recognizes tumor CD146...
December 22, 2017: Oncotarget
https://www.readbyqxmd.com/read/29348098/safety-of-fenbendazole-in-common-peafowl-pavo-cristatus
#2
Sajid Umar, Seema Abbas, Muhammad Irfan Khan, Qamarun Nisa, Muhammad Younus, Kiran Aqil, Rizwan Qayyum, Muhammad Yaqoob, Asif Ali, Muhammad Asif Yaseen, Muhammad Ali Shah
The present study was undertaken to find out the safety levels of fenbendazole in common peafowl. This bird, raised on aviaries and zoos, can be severely parasitized with Ascaridia galli (enteric worms) and Syngamus trachea (gapeworm) along with other parasitic worms. Fenbendazole is a highly effective benzimidazole-class anthelmintic in animals. The objective of this work was to provide target animal safety data in young peafowl and to demonstrate reproductive safety in adult birds. During the experimental study, diets containing fenbendazole at 0, 100, 200 and 300 ppm were fed for 21 days (three times the normal treatment duration)...
January 2018: Pakistan Journal of Pharmaceutical Sciences
https://www.readbyqxmd.com/read/29345708/triphenylstannyl-arylimino-methyl-benzoates-with-selective-potency-that-induce-g1-and-g2-m-cell-cycle-arrest-and-trigger-apoptosis-via-ros-in-human-cervical-cancer-cells
#3
Tushar S Basu Baul, Imliwati Longkumer, Andrew Duthie, Priya Singh, Biplob Koch, M Fátima C Guedes da Silva
Metal complexes with organelle specificity and potent but selective cytotoxicity are highly desirable. A novel series of triphenylstannyl 4-((arylimino)methyl)benzoates (2-8) were obtained by the reactions of triphenylstannyl 4-formylbenzoate [Ph3Sn(L1)] 1 with primary aromatic amines. Two representative compounds (10, 11) were also synthesized by reacting aqua-triphenylstannyl 2-formylbenzoate [Ph3Sn(L9)(H2O)] (9) with aniline and p-fluoroaniline, respectively. These compounds were characterized by elemental analysis, IR and 1H, 13C and 119Sn NMR spectroscopy, as well as single-crystal X-ray diffraction for compounds 5, 7-11 and three pro-ligands...
January 18, 2018: Dalton Transactions: An International Journal of Inorganic Chemistry
https://www.readbyqxmd.com/read/29344587/an-exploratory-study-of-red-raspberry-rubus-idaeus-l-poly-phenols-metabolites-in-human-biological-samples
#4
Xuhuiqun Zhang, Amandeep Sandhu, Indika Edirisinghe, Britt Burton-Freeman
Red raspberry (Rubus idaeus L.) contains a variety of polyphenols including anthocyanins and ellagitannins. Red raspberry polyphenols absorbed in different forms (parent compounds, degradants or microbial metabolites) are subject to xenobiotic metabolism in the intestine, liver, and/or kidney, forming methylate, glucuronide, and sulfate conjugated metabolites. Upon acute exposure, (poly)phenol/metabolite presence in the blood depends mainly on intestinal absorption, enterohepatic circulation, and metabolism by resident microbiota...
January 18, 2018: Food & Function
https://www.readbyqxmd.com/read/29344209/the-effect-of-royal-jelly-on-the-growth-of-breast-cancer-in-mice
#5
Shuang Zhang, Qiqi Shao, Haiyang Geng, Songkun Su
Due to various pharmacological properties, including antioxidative, anti-inflammatory and antibiotic properties, royal jelly (RJ) has been widely consumed in daily diets in numerous countries. In the present study, the effect of RJ on 4T1-bearing mice was investigated. The study was performed by feeding 4T1-bearing mice with RJ using either the prophylactic-therapeutic (PTRJ) or therapeutic (TRJ) method. The experimental results for the PTRJ group demonstrated that the weight of tumor was significantly reduced (RJ 0...
December 2017: Oncology Letters
https://www.readbyqxmd.com/read/29305666/decorated-superparamagnetic-iron-oxide-nanoparticles-with-monoclonal-antibody-and-diethylene-triamine-pentaacetic-acid-labeled-with-thechnetium-99m-and-galium-68-for-breast-cancer-imaging
#6
Marta de Souza Albernaz, Sergio Hiroshi Toma, Jeff Clanton, Koiti Araki, Ralph Santos-Oliveira
PURPOSE: In this study we developed and tested an iron oxide nanoparticle conjugated with DTPA and Trastuzumab, which can efficiently be radiolabeled with 99m-Tc and Ga-68, generating a nanoradiopharmaceutical agent to be used for SPECT and PET imaging. METHODS: The production of iron oxide nanoparticle conjugated with DTPA and Trastuzumab was made using phosphorylethanolamine (PEA) surface modification. Both radiolabeling process was made by the direct radiolabeling of the nanoparticles...
January 5, 2018: Pharmaceutical Research
https://www.readbyqxmd.com/read/29304901/indoor-tanning-a-gianus-bifrons-vitamin-d-and-human-cancer
#7
Giuseppe Lippi, Gianfranco Cervellin, Elisa Danese
Despite it is now undeniable that indoor tanning exposure is associated with a number of skin cancers, its favorable effects on vitamin D status may bear some underestimated and currently unexplored health benefits. Vitamin D is a fat-soluble vitamin naturally present in a limited number of foods, the concentration of which largely depends on ultraviolet (UV) B sources exposure in humans. A strong, graded, and inverse association has been documented between serum vitamin D and the risk of developing certain types of malignancy, especially colorectal, breast, lung, bladder, and kidney cancers...
2018: Advances in Clinical Chemistry
https://www.readbyqxmd.com/read/29304049/cost-and-affordability-of-non-communicable-disease-screening-diagnosis-and-treatment-in-kenya-patient-payments-in-the-private-and-public-sectors
#8
Sujha Subramanian, Robai Gakunga, Joseph Kibachio, Gladwell Gathecha, Patrick Edwards, Elijah Ogola, Gerald Yonga, Naftali Busakhala, Esther Munyoro, Jeremiah Chakaya, Nancy Ngugi, Nyawira Mwangi, Daniel Von Rege, Lili-Marie Wangari, David Wata, Robert Makori, Julius Mwangi, Walter Mwanda
INTRODUCTION: The prevalence of non-communicable diseases (NCDs) is rising in low- and middle-income countries, including Kenya, disproportionately to the rest of the world. Our objective was to quantify patient payments to obtain NCD screening, diagnosis, and treatment services in the public and private sector in Kenya and evaluate patients' ability to pay for the services. METHODS AND FINDINGS: We collected payment data on cardiovascular diseases, diabetes, breast and cervical cancer, and respiratory diseases from Kenyatta National Hospital, the main tertiary public hospital, and the Kibera South Health Center-a public outpatient facility, and private sector practitioners and hospitals...
2018: PloS One
https://www.readbyqxmd.com/read/29300334/understanding-the-progression-of-bone-metastases-to-identify-novel-therapeutic-targets
#9
REVIEW
Annie Schmid-Alliana, Heidy Schmid-Antomarchi, Rasha Al-Sahlanee, Patricia Lagadec, Jean-Claude Scimeca, Elise Verron
Bone is one of the most preferential target site for cancer metastases, particularly for prostate, breast, kidney, lung and thyroid primary tumours. Indeed, numerous chemical signals and growth factors produced by the bone microenvironment constitute factors promoting cancer cell invasion and aggression. After reviewing the different theories proposed to provide mechanism for metastatic progression, we report on the gene expression profile of bone-seeking cancer cells. We also discuss the cross-talk between the bone microenvironment and invading cells, which impacts on the tumour actions on surrounding bone tissue...
January 4, 2018: International Journal of Molecular Sciences
https://www.readbyqxmd.com/read/29299121/klf15-promotes-the-proliferation-and-metastasis-of-lung-adenocarcinoma-cells-and-has-potential-as-a-cancer-prognostic-marker
#10
Lihua Gao, Hongmei Qiu, Jian Liu, Yuzhen Ma, Jia Feng, Li Qian, Jianguo Zhang, Yifei Liu, Tingting Bian
Lung adenocarcinoma (LADC)is a general form of non-small cell lung cancer that represents a significant threat to public health worldwide. The 5-year-survival rate for LADC is currently below 15%. The transcription factor KLF15, also called kidney-enriched KLF (KKLF), has been proven to play a role in inhibiting proliferation and diversification of carcinoma cells, including those of the endometrium, pancreas and breast, but the involvement of KLF15 in LADC has not previously been studied. In this study, we compared the in vitro expression of KLF15 in human LADC tissues and adjacent normal lung tissues...
December 15, 2017: Oncotarget
https://www.readbyqxmd.com/read/29299117/a-new-bioluminescent-reporter-system-to-study-the-biodistribution-of-systematically-injected-tumor-derived-bioluminescent-extracellular-vesicles-in-mice
#11
Prakash Gangadaran, Xiu Juan Li, Ho Won Lee, Ji Min Oh, Senthilkumar Kalimuthu, Ramya Lakshmi Rajendran, Seung Hyun Son, Se Hwan Baek, Thoudam Debraj Singh, Liya Zhu, Shin Young Jeong, Sang-Woo Lee, Jaetae Lee, Byeong-Cheol Ahn
In vivo biodistribution and fate of extracellular vesicles (EVs) are still largely unknown and require reliable in vivo tracking techniques. In this study, in vivo bioluminescence imaging (BLI) using Renilla luciferase (Rluc) was developed and applied to monitoring of EVs derived from thyroid cancer (CAL-62 cells) and breast cancer (MDA-MB-231) in nude mice after intravenous administration and was compared with a dye-based labeling method for EV derived from CAL-62 cells. The EVs were successfully labeled with Rluc and visualized by BLI in mice...
December 15, 2017: Oncotarget
https://www.readbyqxmd.com/read/29289418/long-term-adverse-genitourinary-outcomes-among-endometrial-cancer-survivors-in-a-large-population-based-cohort-study
#12
Sean Soisson, Patricia A Ganz, David Gaffney, Kerry Rowe, John Snyder, Yuan Wan, Vikrant Deshmukh, Mike Newman, Alison Fraser, Ken Smith, Kimberly Herget, Heidi A Hanson, Yelena P Wu, Joseph Stanford, Theresa L Werner, Veronica Wendy Setiawan, Mia Hashibe
OBJECTIVE: With the increasing incidence of endometrial cancer, the high survival rate, and the large number of endometrial cancer survivors, investigations of long-term genitourinary outcomes are important for the management of these outcomes among endometrial cancer survivors. METHODS: Cohorts of 2648 endometrial cancer survivors diagnosed in the state of Utah between 1997 and 2012 and 10,503 general population women were identified. All ICD-9 diagnosis codes were collected from the state's two largest healthcare systems and statewide databases...
December 27, 2017: Gynecologic Oncology
https://www.readbyqxmd.com/read/29287894/-monitoring-of-hypertension-in-patients-orally-treated-by-angiogenesis-inhibitor-in-daily-practice
#13
Lisa Belaid, Sahar Bayat-Makoei, Brigitte Laguerre, Cécile Vigneau
OBJECTIVE: The aim of this study is to measure the monitoring and the incidence of renovascular effects of angiogenesis inhibitors in real population. METHOD: Are included in this descriptive, monocentric, practical study, patients of 18 years old and more, orally treated by angiogenesis inhibitors and monitored in consultation by clinician nurses. The main interest variable is the incidence of hypertension at three months of treatment. RESULTS: From January, 2011 to July, 2014, 324 patients have been included, whose 53% are men...
December 26, 2017: Néphrologie & Thérapeutique
https://www.readbyqxmd.com/read/29284349/association-of-hypertension-and-treatment-outcomes-in-advanced-stage-non-small-cell-lung-cancer-patients-treated-with-bevacizumab-or-non-bevacizumab-containing-regimens
#14
Lily Z Yan, Emily V Dressler, Val R Adams
Background Studies suggest that bevacizumab-induced hypertension is prognostic of better outcomes in bevacizumab-treated patients with metastatic colorectal, HER2-negative breast, kidney, and pancreatic cancer. Few have examined this correlation in metastatic non-small cell lung cancer and evaluated whether hypertension independent of bevacizumab can improve the treatment outcomes. Objectives The primary objective was to determine the effect of hypertension on the overall response of advanced non-small cell lung cancer patients from start of the first-line chemotherapy to maintenance therapy...
January 1, 2017: Journal of Oncology Pharmacy Practice
https://www.readbyqxmd.com/read/29283437/analytic-survey-of-57-cases-of-oral-metastases
#15
Yingci Liu, Richard J Vargo, Elizabeth A Bilodeau
BACKGROUND: Oral lesions have been reported among the first signs of an undiagnosed metastatic disease. Accurate diagnosis of an occult metastasis remains critical in determining the treatment course. Previous studies regarding oral metastatic tumors present varied data regarding the most frequent metastases to the oral cavity. These discrepancies echo the changes in incidence rates for certain malignancies over time and demonstrate the need for periodic updates in oral metastasis studies...
December 28, 2017: Journal of Oral Pathology & Medicine
https://www.readbyqxmd.com/read/29282545/relationship-between-pb-and-cd-accumulations-in-house-crow-their-habitat-and-food-content-from-klang-area-peninsular-malaysia
#16
Mohammed Janaydeh, Ahmad Ismail, Hishamuddin Omar, Syaizwan Zahmir Zulkifli, Mohd Hair Bejo, Nor Azwady Abd Aziz
Heavy metal pollution has become a global concern due to accumulation in tissue and transferable effects to humans via the food chain. This study focused on monitoring the accumulation of cadmium (Cd) and lead (Pb) in surface soil and body content: bone, heart, brain, liver, lung, muscle, kidney, feathers, feces, and gizzard contents of house crow Corvus splendens in the Klang region, Malaysia. The results revealed the occurrence of Pb and Cd in all biological samples from house crows, food contents, and surface soil samples...
December 27, 2017: Environmental Monitoring and Assessment
https://www.readbyqxmd.com/read/29278988/cytotoxic-activity-of-the-bioactive-principles-from-ficus-burtt-davyi
#17
Olumuyiwa O Ogunlaja, Roshila Moodley, Moganavelli Singh, Himansu Baijnath, Sreekanth B Jonnalagadda
Ficus burtt-davyi (Moraceae) is a medicinal plant species indigenous to Southern Africa. In this study, a phytochemical and cytotoxic investigation on F. burtt-davyi was conducted to evaluate its ethno-medicinal use. The phytochemical study of the fruits yielded triterpenoids (lupeol and α-amyrin). The cytotoxic evaluation was done on the methanolic extracts and selected compounds, lupeol, α-amyrin, lupeol acetate and (+)-catechin isolated from F. burtt-davyi stem bark and fruits. The 3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyltetrazolium bromide (MTT) cell viability assay was carried out against two human cancer cell lines, breast adenocarcinoma (MCF-7) and colorectal adenocarcinoma (Caco-2), and normal human embryonic kidney cells (HEK293)...
December 26, 2017: Journal of Environmental Science and Health. Part. B, Pesticides, Food Contaminants, and Agricultural Wastes
https://www.readbyqxmd.com/read/29277767/antitumor-memory-t-cells-become-functionally-mature-from-30-to-100-days-in-a-mouse-model-of-neoplasia
#18
Yanhua Gao, Mamdouha A Barmada, Ira Bergman
BACKGROUND: Late metastases develop from cancer of the breast, prostate, lung, kidney and malignant melanomas. Memory T-cells have excellent potential to prevent this devastating development in the same way that they routinely prevent emergence of latent viruses. MATERIAL AND METHODS: A peritoneal tumor mouse model of viral oncotherapy was used to generate therapeutic antitumor memory T-cells. Functional in vivo and in vitro assays were used to study the temporal evolution of their anticancer effects...
January 2018: Anticancer Research
https://www.readbyqxmd.com/read/29277326/identification-of-the-functional-alteration-signatures-across-different-cancer-types-with-support-vector-machine-and-feature-analysis
#19
ShaoPeng Wang, YuDong Cai
Cancers are regarded as malignant proliferations of tumor cells present in many tissues and organs, which can severely curtail the quality of human life. The potential of using plasma DNA for cancer detection has been widely recognized, leading to the need of mapping the tissue-of-origin through the identification of somatic mutations. With cutting-edge technologies, such as next-generation sequencing, numerous somatic mutations have been identified, and the mutation signatures have been uncovered across different cancer types...
December 19, 2017: Biochimica et Biophysica Acta
https://www.readbyqxmd.com/read/29247890/automated-localization-and-segmentation-techniques-for-b-mode-ultrasound-images-a-review
#20
REVIEW
Kristen M Meiburger, U Rajendra Acharya, Filippo Molinari
B-mode ultrasound imaging is used extensively in medicine. Hence, there is a need to have efficient segmentation tools to aid in computer-aided diagnosis, image-guided interventions, and therapy. This paper presents a comprehensive review on automated localization and segmentation techniques for B-mode ultrasound images. The paper first describes the general characteristics of B-mode ultrasound images. Then insight on the localization and segmentation of tissues is provided, both in the case in which the organ/tissue localization provides the final segmentation and in the case in which a two-step segmentation process is needed, due to the desired boundaries being too fine to locate from within the entire ultrasound frame...
December 6, 2017: Computers in Biology and Medicine
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