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Diabetes, Thyroid, Hypertension, Lipids

Trang N Le, Francesco S Celi, Edmond P Wickham
BACKGROUND: Increased thyrotropin (TSH) levels and free triiodothyronine to free thyroxine (fT3:fT4) ratios, even within the euthyroid range, have been associated with cardiometabolic risk factors in adults but are less characterized in youth. This study sought to determine relations between TSH, thyroid hormones, and cardiometabolic risk factors in euthyroid adolescents. METHODS: Data were extracted from the United States National Health and Nutrition Examination Survey, 2007-2010, for univariate and multivariate analyses of TSH, thyroid hormones, body mass index (BMI), blood pressure, lipids, and glucose metabolism...
October 2016: Thyroid: Official Journal of the American Thyroid Association
Jacek Lelakowski, Joanna Pudło, Maria Lelakowska-Pieła, Anna Rydlewska, Justyna Piekarz, Donat Domaracki
UNLABELLED: Ambulatory follow-up of patients with implanted cardioverter-defibrillator (ICD) with/without resynchronisation therapy (CRTD) requires regular visits to assess arrhythmias, device interventions and mortality. AIM: The aim of the study was to examine arrhythmia prevalence, device interventions and mortality in patients with dilative cardiomyopathy with ICD/CRTD implanted in primary sudden cardiac death (SCD) prevention. MATERIALS AND METHODS: The study consisted of patients with ICD and/or CRTD implanted between 2010-2011...
April 2016: Polski Merkuriusz Lekarski: Organ Polskiego Towarzystwa Lekarskiego
Yaowen Wang, Litao Zhang, Jianhua Zhang, Xuqun Zhang, Weimin Zhang, Xing Chen, Shixiong Tang
The objective of this study is to investigate the clinical characteristics of successive bilateral sudden sensorineural hearing loss (SSNHL) with an interval of more than 1 year to aid the evaluation and management of successive bilateral SSNHL (BSSNHL). 14 successive BSSNHL patients and 118 unilateral SSNHL patients with severe and profound hearing loss were reviewed retrospectively. Information about successive BSSNHL was collected included demographics, the intervals between the attacks of bilateral ears, the past medical history, inducing factors, accompanying symptoms, pure-tone tests, blood tests, b-ultrasound examinations of vertebral artery and carotid artery, and medical interventions...
April 6, 2016: European Archives of Oto-rhino-laryngology
Saroj Khatiwada, K C Rajendra, Sharad Gautam, Madhab Lamsal, Nirmal Baral
BACKGROUND: Chronic kidney disease (CKD) is becoming a serious health problem; the number of people with impaired renal function is rapidly rising. Progression of CKD is associated with having a number of complications, including thyroid dysfunction, dyslipidemia and cardiovascular diseases. This study was conducted to investigate thyroid function and lipid profile in CKD patients. METHODS: A cross-sectional study was conducted among 360 chronic kidney disease patients at B P Koirala Institute of Health Sciences, Dharan, Nepal...
2015: BMC Endocrine Disorders
Lei Zheng, Wenhua Yan, Yue Kong, Ping Liang, Yiming Mu
Thyroid nodule (TN) and goiter are two common disorders of the thyroid. Despite their benign nature, both conditions can be associated with multiple pathologic conditions including thyroid cancer. In this study, we conducted a large-scale epidemiological study in Chinese women to identify the risk factors implicated in the occurrence of TN and goiter. We analyzed demographic data, lifestyle, medical history, body height, weight, waist circumference, body mass index (BMI), blood pressure, serum glucose and lipids...
September 2015: International Journal of Environmental Research and Public Health
Marcin Gierach, Roman Junik
INTRODUCTION: Metabolic syndrome involves abdominal obesity, arterial hypertension, type 2 diabetes and lipid disorders manifested as atherogenic dyslipidaemia. Abnormal thyroid function affects the severity of MetS components, since regulating metabolism is one of the most important functions of thyroid hormones. In this study, we present the influence of hypothyroidism on lipid and carbohydrate disorders in patients with MetS. MATERIAL AND METHODS: The described study was a prospective, two-centre screening study of 24-month duration...
2015: Endokrynologia Polska
Kinga Anna Budai, Arash Mirzahosseini, Noszál Béla, Gergő Tóth
Obesity is considered the most concerning and blatantly visible--yet most neglected--public health problem by the WHO. The steadily increasing number of overweight and obese people has reached 2.3 billion and 700 million worldwide, respectively. Obesity is a complex condition, one that presents serious health risks with respect to type 2 diabetes, ischemic heart disease, and hypertension, therefore controlling the global obesity epidemic decreases not only health problems, but also expenditure. The underlying cause of obesity is a metabolic disorder of genetic, central nervous system or endocrine etiology that manifests in increased nutritional intake and/or decreased physical activity ultimately leading to excessive lipogenesis...
2015: Acta Pharmaceutica Hungarica
Alexander Shinkov, Anna-Maria Borissova, Roussanka Kovatcheva, Iliana Atanassova, Jordan Vlahov, Lilia Dakovska
OBJECTIVE: The aim of the study was to assess the prevalence and characteristics of metabolic syndrome (MetS) and its elements in relation to TSH in euthyroid subjects. MATERIALS AND METHODS: In the cross-sectional study, 2,153 euthyroid adults, 47.2 ± 14.5 years (20-94) with no current antithyroid or thyroid replacement therapy were enrolled. All participants filled a questionnaire on past and current morbidities, medication and smoking. Body weight, height, waist circumference, serum TSH, glucose and lipids were measured...
December 2014: Arquivos Brasileiros de Endocrinologia e Metabologia
K Gruzewska, A Michno, T Pawelczyk, H Bielarczyk
The biological properties of vanadium complexes have become an object of interest due to their therapeutic potential in several diseases. However, the mechanisms of action of vanadium salts are still poorly understood. Vanadium complexes are cofactors for several enzymes and also exhibit insulin-mimetic properties. Thus, they are involved in the regulation of glucose metabolism, including in patients with diabetes. In addition, vanadium salts may also normalize blood pressure and play a key role in the metabolism of the thyroid and of iron as well as in the regulation of total cholesterol, cholesterol HDL and triglyceride (TG) levels in blood...
October 2014: Journal of Physiology and Pharmacology: An Official Journal of the Polish Physiological Society
Gemma Rojo-Martínez, Sergio Valdés, Natalia Colomo, M Isabel Lucena, Sonia Gaztambide, Ramón Gomis, Roser Casamitjana, Rafael Carmena, Miguel Catalá, María T Martínez-Larrad, Manuel Serrano-Ríos, Luis Castaño, Joan Vendrell, Juan Girbés, Josep Franch, José A Vázquez, Inmaculada Mora-Peces, Inés Urrutia, Gemma Pascual-Manich, Emilio Ortega, Edelmiro Menéndez, Elias Delgado, Elena Bordiú, Conxa Castell, Alfonso López-Alba, Alberto Goday, Alfonso Calle, Anna Bosch-Comas, Federico Soriguer
INTRODUCTION AND OBJECTIVES: To assess the patterns of use of 8 therapeutic drug groups for the treatment of diabetes mellitus and other cardiovascular risk factors, and to identify sociodemographic and health determinants of their use in the overall Spanish population. METHODS: A representative sample of the Spanish population within the study, a cross-sectional population-based survey, was included. STUDY VARIABLES: sociodemographic, clinical, and lifestyle data; physical examination, and an oral glucose tolerance test in patients without known diabetes mellitus...
November 2013: Revista Española de Cardiología
Pakize Karakaya, Sebnem Yılmaz, Ozlem Tüfekçi, Mustafa Kır, Ece Böber, Gülersu Irken, Hale Oren
OBJECTIVE: Survival rates for childhood acute lymphoblastic leukemia (ALL) have significantly improved and late effects of therapy have been important in the follow-up of survivors. The objective of this study is to identify the endocrinological and cardiological late effects of ALL patients treated in our pediatric hematology unit. MATERIALS AND METHODS: Patients treated for ALL with BFM protocols after at least 5 years of diagnosis and not relapsed were included in the study...
September 2013: Turkish Journal of Haematology: Official Journal of Turkish Society of Haematology
N Karthick, K Dillara, K N Poornima, A S Subhasini
BACKGROUND: In overt hypothyroidism, many lipid abnormalities have been documented. This study was intended to demonstrate the levels of lipid in women with subclinical hypothyroidism (SH). MATERIAL AND METHODS: This was a case control study which was done at referral Centre in Chennai. Women with subclinical hypothyroidism and euthyroid women attending our master health checkup clinic were enrolled in this study.Their lipid profile, fasting blood sugar, T3,T4 and TSH levels were measured...
October 2013: Journal of Clinical and Diagnostic Research: JCDR
Peter N Taylor, Ahmed Iqbal, Caroline Minassian, Adrian Sayers, Mohd S Draman, Rosemary Greenwood, William Hamilton, Onyebuchi Okosieme, Vijay Panicker, Sara L Thomas, Colin Dayan
IMPORTANCE: Rates of thyroid hormone prescribing in the United States and the United Kingdom have increased substantially. If some of the increase is due to lowering the thyrotropin threshold for treatment, this may result in less benefit and greater harm. OBJECTIVE: To define trends in thyrotropin levels at the initiation of levothyroxine sodium therapy and the risk of developing a suppressed thyrotropin level following treatment. DESIGN, SETTING, PARTICIPANTS, AND EXPOSURE: Retrospective cohort study using data from the United Kingdom Clinical Practice Research Datalink...
January 2014: JAMA Internal Medicine
F T Ageev, I V Barinova, E M Seredenina, Ia A Orlova, A E Kuz'mina, V P Masenko, A G Kochetov
OBJECTIVE: to evaluate the relationship between arterial stiffness and bone metabolism in women with mild to moderate risk of cardiovascular disease (CVD). METHODS: In 103 postmenopausal women (mean age 57.0 years, 95% CI 50.0-64.0) with mild to moderate risk of CVD (SCORE<5), no more than mild hypertension, normal function of thyroid gland, without coronary artery disease, diabetes mellitus and secondary causes of osteoporosis pulse wave velocity between carotid and femoral sites (cfPWV, by applanation tonometry) and ankle and brachial sites (baPWV, by volume sphygmography) as well as bone mineral density at lumbar spine and femoral neck (by dual-energy X-ray absorptiometry) and blood serum levels of markers of bone turnover (total procollagen type I amino-terminal propeptide (PINP), osteocalcin, collagen type 1 cross-linked C-telopeptide (-CTX) by electrochemilumininescence immunoassay) were assessed...
2013: Kardiologiia
Fereidoun Azizi, Atieh Amouzegar, Hossein Delshad, Maryam Tohidi, Ladan Mehran, Yadollah Mehrabi
BACKGROUND: There is a lack of data regarding the incidence rate, etiology, risk factors, and natural course of thyroid disorders and their relationship with cardiovascular disease and mortality in populations undergoing nutrition transition. Therefore, we aimed to assess the natural course of thyroid disease in Tehranians, a population in nutrition transition. METHODS AND DESIGN: Between March 1997 and December 2004, 5769 individuals, aged ≥ 20 years, were selected from district No...
July 2013: Archives of Iranian Medicine
Iwona Gorczyca-Michta, Beata Wożakowska-Kapłon, Ewa Tomasik
BACKGROUND: Hypertension, due to its prevalence, is a common and independent risk factor for atrial fibrillation (AF). High blood pressure causes structural and functional changes in the myocardium, leading to an increased risk of arrhythmia. This risk is higher when hypertension is accompanied by concomitant diseases that contribute to the development of AF. AIM: To estimate prevalence of AF and predisposing factors for AF in patients with hypertension hospitalised in our cardiology unit...
2013: Kardiologia Polska
Hongwei Guo, Min Sun, Wei He, Huanhuan Chen, Wen Li, Jinmei Tang, Wei Tang, Jieli Lu, Yufang Bi, Guang Ning, Tao Yang, Yu Duan
To investigate the prevalence of thyroid nodules (TN) among a community population aged >40 years and to explore the association between TN and its metabolic risk factors. Data from 9,533 adults aged over 40 years who participated in the epidemiological investigation of thyroid nodules in a Chinese community-based population from June to December 2011 were included in the analyses. We compared the levels of metabolic indices between the TN group and healthy controls. The prevalence of TN was 46.6% (39.7%, men; 50...
March 2014: Endocrine
Cenk Aypak, Ozlem Türedi, Adnan Yüce, Süleyman Görpelioğlu
OBJECTIVE: In recent years, there has been increasing focus on thyroid function in pediatric obese patients. Our aims were to investigate whether there is an association between serum thyroid-stimulating hormone (TSH) within the normal range and body mass index (BMI), and to determine if TSH levels correlate with metabolic risk factors in children. METHODS: A retrospective cross-sectional analysis was carried out on 528 euthyroid, age- and sex-matched lean, overweight, or obese children...
2013: Journal of Pediatric Endocrinology & Metabolism: JPEM
Luis García-Olmos, Angel Alberquilla, Victoria Ayala, Pilar García-Sagredo, Leticia Morales, Montserrat Carmona, María José de Tena-Dávila, Mario Pascual, Adolfo Muñoz, Carlos H Salvador, Jose L Monteagudo
BACKGROUND: Chronic obstructive pulmonary disease (COPD) is frequent and often coexists with other diseases. The aim of this study was to quantify the prevalence of COPD and related chronic comorbidity among patients aged over 40 years visiting family practices in an area of Madrid. METHODS: An observational, descriptive, cross-sectional study was conducted in a health area of the Madrid Autonomous Region (Comunidad Autónoma de Madrid). The practice population totalled 198,670 persons attended by 129 Family Physicians (FPs), and the study population was made up of persons over the age of 40 years drawn from this practice population...
2013: BMC Family Practice
Ingmar Schäfer
OBJECTIVE: Multimorbidity is a complex phenomenon with an almost endless number of possible disease combinations with unclear implications. One important aspect in analyzing the clustering of diseases is to distinguish between random coexistence and statistical dependency. We developed a model to account for random coexistence based on stochastic distribution. We analyzed if the number of diseases of the patients influences the occurrence rates of chronic conditions. METHODS: We analyzed claims data of 121,389 persons aged 65+ using a list of 46 chronic conditions...
2012: PloS One
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