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Diabetes, Thyroid, Hypertension, Lipids

Yi Chen, Chunfang Zhu, Yingchao Chen, Ningjian Wang, Qin Li, Bing Han, Li Zhao, Chi Chen, Hualing Zhai, Yingli Lu
Purpose: The aim of this study was to investigate the association of thyroid nodules (TNs) and their ultrasound (US) characteristics related to malignancy with metabolic status. Methods: The data were obtained from a cross-sectional study (SPECT-China, 2014-2015). The study included 9898 participants older than 18 years. Participants underwent several checkups, which included the measurement of anthropometric parameters, blood pressure, TSH levels, glucose, and lipid profiles...
2018: International Journal of Endocrinology
Xiangxiang Wang, Qingbo Guan, Jiajun Zhao, Feifei Yang, Zhongshang Yuan, Yongchao Yin, Rui Fang, Lingwei Liu, Changting Zuo, Ling Gao
BACKGROUND: Macrosomia is a serious public health problem worldwide due to its increasing prevalence and adverse influences on maternal and neonatal outcomes. Maternal dyslipidemia exerts potential and adverse impacts on pregnant women and newborns. However, the association between maternal serum lipids and the risk of macrosomia has not yet been clearly elucidated. We explored the association between the maternal lipids profile at late gestation and the risk of having macrosomia among women without diabetes mellitus (DM)...
April 11, 2018: Lipids in Health and Disease
Giovanni De Pergola, Vincenzo Triggiani, Nicola Bartolomeo, Vito Angelo Giagulli, Michele Anelli, Michele Masiello, Vittoria Candita, Dario De Bellis, Franco Silvestris
BACKGROUND: Low vitamin D levels have been associated with autoimmune disorders and, then, with the Hashimoto's autoimmune thyroiditis (AT), the most common autoimmune disease. Obesity is characterized by lower vitamin D levels and higher risk to develop autoimmune diseases. The aim of the study was to examine the possibility of an association between AT and decreased 25(OH) vitamin D (25(OH)D) levels in a cohort of otherwise healthy overweight and obese subjects. MATERIALS AND METHODS: Two hundred sixty one overweight subjects (mean age: 40...
April 6, 2018: Endocrine, Metabolic & Immune Disorders Drug Targets
Yonggu Lee, Young-Hyo Lim, Jeong-Hun Shin, Jinkyu Park, Jinho Shin
BACKGROUND: Similar to overt hypothyroidism, subclinical hypothyroidism (SCH) has been reported to increase the risk of cardiovascular disease. However, the influence of SCH on clinical outcomes following percutaneous coronary intervention (PCI) remains unclear. METHODS: We performed a prospective cohort study. SCH was defined as a thyroid-stimulating hormone (TSH) level ≥4.5mIU/l and a normal level of free thyroxine (FT4). A composite event was defined as the combination of cardiac death, non-fatal myocardial infarction (MI) and repeat revascularization...
February 15, 2018: International Journal of Cardiology
Nooshin Salehi, Endre Agoston, Iqbal Munir, Gary J Thompson
BACKGROUND Muscular symptoms, including stiffness, myalgia, cramps, and fatigue, are present in the majority of the patients with symptomatic hypothyroidism, but rhabdomyolysis, the rapid breakdown of skeletal muscle, is a rare manifestation. In most patients with hypothyroidism who develop rhabdomyolysis, precipitating factors, such as strenuous exercise or use of lipid-lowering drugs, can be identified. CASE REPORT We report a case of a 52-year-old Hispanic woman with a history of hypothyroidism, hypertension, and type 2 diabetes mellitus who presented with fatigue, severe generalized weakness, bilateral leg pain, and recurrent falls...
August 22, 2017: American Journal of Case Reports
Alessandro P Delitala, Giuseppe Fanciulli, Giovanni M Pes, Margherita Maioli, Giuseppe Delitala
Metabolic syndrome is a clustering of various metabolic parameters, which included diabetes, low high-density lipoprotein cholesterol, elevated triglycerides, abdominal obesity, and hypertension. It has merged as a worldwide epidemic and a major public health care concern. However, due to the different criteria used for the assessment, the frequency of metabolic syndrome in the general population is variable but it more common in the older people. Metabolic syndrome is closely linked to cardiovascular risk and increases cardiovascular outcomes and all-cause mortality...
March 20, 2017: Endocrine, Metabolic & Immune Disorders Drug Targets
Trang N Le, Francesco S Celi, Edmond P Wickham
BACKGROUND: Increased thyrotropin (TSH) levels and free triiodothyronine to free thyroxine (fT3:fT4) ratios, even within the euthyroid range, have been associated with cardiometabolic risk factors in adults but are less characterized in youth. This study sought to determine relations between TSH, thyroid hormones, and cardiometabolic risk factors in euthyroid adolescents. METHODS: Data were extracted from the United States National Health and Nutrition Examination Survey, 2007-2010, for univariate and multivariate analyses of TSH, thyroid hormones, body mass index (BMI), blood pressure, lipids, and glucose metabolism...
October 2016: Thyroid: Official Journal of the American Thyroid Association
Jacek Lelakowski, Joanna Pudło, Maria Lelakowska-Pieła, Anna Rydlewska, Justyna Piekarz, Donat Domaracki
UNLABELLED: Ambulatory follow-up of patients with implanted cardioverter-defibrillator (ICD) with/without resynchronisation therapy (CRTD) requires regular visits to assess arrhythmias, device interventions and mortality. AIM: The aim of the study was to examine arrhythmia prevalence, device interventions and mortality in patients with dilative cardiomyopathy with ICD/CRTD implanted in primary sudden cardiac death (SCD) prevention. MATERIALS AND METHODS: The study consisted of patients with ICD and/or CRTD implanted between 2010-2011...
April 2016: Polski Merkuriusz Lekarski: Organ Polskiego Towarzystwa Lekarskiego
Yaowen Wang, Litao Zhang, Jianhua Zhang, Xuqun Zhang, Weimin Zhang, Xing Chen, Shixiong Tang
The objective of this study is to investigate the clinical characteristics of successive bilateral sudden sensorineural hearing loss (SSNHL) with an interval of more than 1 year to aid the evaluation and management of successive bilateral SSNHL (BSSNHL). 14 successive BSSNHL patients and 118 unilateral SSNHL patients with severe and profound hearing loss were reviewed retrospectively. Information about successive BSSNHL was collected included demographics, the intervals between the attacks of bilateral ears, the past medical history, inducing factors, accompanying symptoms, pure-tone tests, blood tests, b-ultrasound examinations of vertebral artery and carotid artery, and medical interventions...
November 2016: European Archives of Oto-rhino-laryngology
Saroj Khatiwada, K C Rajendra, Sharad Gautam, Madhab Lamsal, Nirmal Baral
BACKGROUND: Chronic kidney disease (CKD) is becoming a serious health problem; the number of people with impaired renal function is rapidly rising. Progression of CKD is associated with having a number of complications, including thyroid dysfunction, dyslipidemia and cardiovascular diseases. This study was conducted to investigate thyroid function and lipid profile in CKD patients. METHODS: A cross-sectional study was conducted among 360 chronic kidney disease patients at B P Koirala Institute of Health Sciences, Dharan, Nepal...
October 29, 2015: BMC Endocrine Disorders
Lei Zheng, Wenhua Yan, Yue Kong, Ping Liang, Yiming Mu
Thyroid nodule (TN) and goiter are two common disorders of the thyroid. Despite their benign nature, both conditions can be associated with multiple pathologic conditions including thyroid cancer. In this study, we conducted a large-scale epidemiological study in Chinese women to identify the risk factors implicated in the occurrence of TN and goiter. We analyzed demographic data, lifestyle, medical history, body height, weight, waist circumference, body mass index (BMI), blood pressure, serum glucose and lipids...
September 16, 2015: International Journal of Environmental Research and Public Health
Marcin Gierach, Roman Junik
INTRODUCTION: Metabolic syndrome involves abdominal obesity, arterial hypertension, type 2 diabetes and lipid disorders manifested as atherogenic dyslipidaemia. Abnormal thyroid function affects the severity of MetS components, since regulating metabolism is one of the most important functions of thyroid hormones. In this study, we present the influence of hypothyroidism on lipid and carbohydrate disorders in patients with MetS. MATERIAL AND METHODS: The described study was a prospective, two-centre screening study of 24-month duration...
2015: Endokrynologia Polska
Kinga Anna Budai, Arash Mirzahosseini, Noszál Béla, Gergő Tóth
Obesity is considered the most concerning and blatantly visible--yet most neglected--public health problem by the WHO. The steadily increasing number of overweight and obese people has reached 2.3 billion and 700 million worldwide, respectively. Obesity is a complex condition, one that presents serious health risks with respect to type 2 diabetes, ischemic heart disease, and hypertension, therefore controlling the global obesity epidemic decreases not only health problems, but also expenditure. The underlying cause of obesity is a metabolic disorder of genetic, central nervous system or endocrine etiology that manifests in increased nutritional intake and/or decreased physical activity ultimately leading to excessive lipogenesis...
2015: Acta Pharmaceutica Hungarica
Alexander Shinkov, Anna-Maria Borissova, Roussanka Kovatcheva, Iliana Atanassova, Jordan Vlahov, Lilia Dakovska
OBJECTIVE: The aim of the study was to assess the prevalence and characteristics of metabolic syndrome (MetS) and its elements in relation to TSH in euthyroid subjects. MATERIALS AND METHODS: In the cross-sectional study, 2,153 euthyroid adults, 47.2 ± 14.5 years (20-94) with no current antithyroid or thyroid replacement therapy were enrolled. All participants filled a questionnaire on past and current morbidities, medication and smoking. Body weight, height, waist circumference, serum TSH, glucose and lipids were measured...
December 2014: Arquivos Brasileiros de Endocrinologia e Metabologia
K Gruzewska, A Michno, T Pawelczyk, H Bielarczyk
The biological properties of vanadium complexes have become an object of interest due to their therapeutic potential in several diseases. However, the mechanisms of action of vanadium salts are still poorly understood. Vanadium complexes are cofactors for several enzymes and also exhibit insulin-mimetic properties. Thus, they are involved in the regulation of glucose metabolism, including in patients with diabetes. In addition, vanadium salts may also normalize blood pressure and play a key role in the metabolism of the thyroid and of iron as well as in the regulation of total cholesterol, cholesterol HDL and triglyceride (TG) levels in blood...
October 2014: Journal of Physiology and Pharmacology: An Official Journal of the Polish Physiological Society
Gemma Rojo-Martínez, Sergio Valdés, Natalia Colomo, M Isabel Lucena, Sonia Gaztambide, Ramón Gomis, Roser Casamitjana, Rafael Carmena, Miguel Catalá, María T Martínez-Larrad, Manuel Serrano-Ríos, Luis Castaño, Joan Vendrell, Juan Girbés, Josep Franch, José A Vázquez, Inmaculada Mora-Peces, Inés Urrutia, Gemma Pascual-Manich, Emilio Ortega, Edelmiro Menéndez, Elias Delgado, Elena Bordiú, Conxa Castell, Alfonso López-Alba, Alberto Goday, Alfonso Calle, Anna Bosch-Comas, Federico Soriguer
INTRODUCTION AND OBJECTIVES: To assess the patterns of use of 8 therapeutic drug groups for the treatment of diabetes mellitus and other cardiovascular risk factors, and to identify sociodemographic and health determinants of their use in the overall Spanish population. METHODS: A representative sample of the Spanish population within the study, a cross-sectional population-based survey, was included. STUDY VARIABLES: sociodemographic, clinical, and lifestyle data; physical examination, and an oral glucose tolerance test in patients without known diabetes mellitus...
November 2013: Revista Española de Cardiología
Pakize Karakaya, Sebnem Yılmaz, Ozlem Tüfekçi, Mustafa Kır, Ece Böber, Gülersu Irken, Hale Oren
OBJECTIVE: Survival rates for childhood acute lymphoblastic leukemia (ALL) have significantly improved and late effects of therapy have been important in the follow-up of survivors. The objective of this study is to identify the endocrinological and cardiological late effects of ALL patients treated in our pediatric hematology unit. MATERIALS AND METHODS: Patients treated for ALL with BFM protocols after at least 5 years of diagnosis and not relapsed were included in the study...
September 2013: Turkish Journal of Haematology: Official Journal of Turkish Society of Haematology
N Karthick, K Dillara, K N Poornima, A S Subhasini
BACKGROUND: In overt hypothyroidism, many lipid abnormalities have been documented. This study was intended to demonstrate the levels of lipid in women with subclinical hypothyroidism (SH). MATERIAL AND METHODS: This was a case control study which was done at referral Centre in Chennai. Women with subclinical hypothyroidism and euthyroid women attending our master health checkup clinic were enrolled in this study.Their lipid profile, fasting blood sugar, T3,T4 and TSH levels were measured...
October 2013: Journal of Clinical and Diagnostic Research: JCDR
Peter N Taylor, Ahmed Iqbal, Caroline Minassian, Adrian Sayers, Mohd S Draman, Rosemary Greenwood, William Hamilton, Onyebuchi Okosieme, Vijay Panicker, Sara L Thomas, Colin Dayan
IMPORTANCE: Rates of thyroid hormone prescribing in the United States and the United Kingdom have increased substantially. If some of the increase is due to lowering the thyrotropin threshold for treatment, this may result in less benefit and greater harm. OBJECTIVE: To define trends in thyrotropin levels at the initiation of levothyroxine sodium therapy and the risk of developing a suppressed thyrotropin level following treatment. DESIGN, SETTING, PARTICIPANTS, AND EXPOSURE: Retrospective cohort study using data from the United Kingdom Clinical Practice Research Datalink...
January 2014: JAMA Internal Medicine
F T Ageev, I V Barinova, E M Seredenina, Ia A Orlova, A E Kuz'mina, V P Masenko, A G Kochetov
OBJECTIVE: to evaluate the relationship between arterial stiffness and bone metabolism in women with mild to moderate risk of cardiovascular disease (CVD). METHODS: In 103 postmenopausal women (mean age 57.0 years, 95% CI 50.0-64.0) with mild to moderate risk of CVD (SCORE<5), no more than mild hypertension, normal function of thyroid gland, without coronary artery disease, diabetes mellitus and secondary causes of osteoporosis pulse wave velocity between carotid and femoral sites (cfPWV, by applanation tonometry) and ankle and brachial sites (baPWV, by volume sphygmography) as well as bone mineral density at lumbar spine and femoral neck (by dual-energy X-ray absorptiometry) and blood serum levels of markers of bone turnover (total procollagen type I amino-terminal propeptide (PINP), osteocalcin, collagen type 1 cross-linked C-telopeptide (-CTX) by electrochemilumininescence immunoassay) were assessed...
2013: Kardiologiia
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