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https://www.readbyqxmd.com/read/28634290/geospatial-analysis-of-nonmedical-vaccine-exemptions-and-pertussis-outbreaks-in-the-united-states
#1
Carlin Aloe, Martin Kulldorff, Barry R Bloom
Because of increased numbers of recorded pertussis cases in the United States, this study sought to understand the role of nonmedical vaccine exemptions and waning immunity may have had on the resurgence of pertussis in the United States at the community level. We used geospatial scan statistics, SaTScan, version 9.4, to analyze nonmedical vaccine exemptions of children entering kindergarten in 2011 and 2012 and reported pertussis cases in 2012 for children in age groups 5 years and younger and 10 to 14 years...
June 20, 2017: Proceedings of the National Academy of Sciences of the United States of America
https://www.readbyqxmd.com/read/28632823/-features-of-bordetella-pertussis-bordetella-spp-infection-and-whopping-cough-in-c%C3%A3-rdoba-province-argentina
#2
Víctor O Giayetto, Sebastián Blanco, Arnaldo Mangeaud, María G Barbás, Analía Cudolá, Sandra V Gallego
INTRODUCTION: Whooping cough is a re-emerging infection in the world and Latin America. OBJECTIVE: It was considered relevant to investigate the clinical and epidemiological profile of Bordetella spp. and Bordetella pertussis infection in Córdoba province, Argentina; evaluating, at the same time, the co-infection with virus producing respiratory infections that may be confused with whooping cough. MATERIAL AND METHODS: All whooping cough suspected cases were studied by Polimerase Chain Reaction, amplifying the repeated insertion sequence (IS) 481 and the promoter gene encoding pertussis toxin, between 2011 and 2013...
April 2017: Revista Chilena de Infectología: órgano Oficial de la Sociedad Chilena de Infectología
https://www.readbyqxmd.com/read/28623916/using-record-linkage-to-validate-notification-and-laboratory-data-for-a-more-accurate-assessment-of-notifiable-infectious-diseases
#3
Faye J Lim, Christopher C Blyth, Avram Levy, Parveen Fathima, Nicholas de Klerk, Carolien Giele, Hannah C Moore
BACKGROUND: Infectious disease burden is commonly assessed using notification data. Using retrospective record linkage in Western Australia, we described how well notification data captures laboratory detections of influenza, pertussis and invasive pneumococcal disease (IPD). METHODS: We linked data from the Western Australian Notifiable Infectious Diseases Database (WANIDD) and the PathWest Laboratory Database (PathWest) pertaining to the Triple I birth cohort, born in Western Australia in 1996-2012...
June 17, 2017: BMC Medical Informatics and Decision Making
https://www.readbyqxmd.com/read/28623456/pertussis-and-rotavirus-vaccines-controversies-and-solutions
#4
REVIEW
Nabaneeta Dash, Sanjay Verma
Pertussis and rotavirus vaccines have been the subject of several controversies over the years. In this paper the authors discuss facts and myths behind these controversies and also suggest solutions to overcome some limitations of these vaccines. The whole-cell pertussis vaccine (wPV) came into disrepute due to the associated adverse reactions, resulting in its replacement by acellular pertussis vaccine (aPV) in industrialized nations in 1990s. Although wPV is known to have more side effects; but they are usually minor...
June 16, 2017: Indian Journal of Pediatrics
https://www.readbyqxmd.com/read/28623146/an-update-of-the-global-burden-of-pertussis-in-children-younger-than-5-years-a-modelling-study
#5
Karene Hoi Ting Yeung, Philippe Duclos, E Anthony S Nelson, Raymond Christiaan W Hutubessy
BACKGROUND: Since the publication in 2003 of a model to estimate the disease burden of pertussis, new evidence of the protective effect of incomplete pertussis vaccination against severe pertussis has been reported. We revised the model to provide new estimates of regional and global pertussis cases and deaths for children younger than 5 years. METHODS: We developed a revised model with data from 2014 to estimate pertussis cases and deaths. Pertussis cases were defined according to the WHO clinical case definition, as a coughing illness lasting at least 2 weeks with paroxysms of coughing, inspiratory whooping, or post-tussive vomiting...
June 13, 2017: Lancet Infectious Diseases
https://www.readbyqxmd.com/read/28623145/global-burden-of-pertussis-signs-of-hope-but-need-for-accurate-data
#6
C H Wirsing von Koenig, Nicole Guiso
No abstract text is available yet for this article.
June 13, 2017: Lancet Infectious Diseases
https://www.readbyqxmd.com/read/28623110/pertussis-without-apparent-cough-in-a-disabled-girl-with-a-tracheostomy
#7
Hisataka Nozawa, Kensuke Shoji, Kazuhiro Uda, Tomoo Nakamura, Mitsuru Kubota, Akira Ishiguro, Isao Miyairi
Pertussis is characterized by intense, prolonged coughing in children often followed by a distinctive whooping sound on inspiration. However, the clinical manifestations and natural course of pertussis in disabled children are largely unknown. We experienced a case of pertussis in a disabled girl who had previously undergone a tracheostomy and laryngotracheal separation. She presented with increased tracheal secretions and required hospitalization but did not develop a cough. Pertussis was suspected from the sputum Gram stain, which revealed numerous, short gram-negative rods that did not grow on chocolate agar...
June 13, 2017: Journal of Infection and Chemotherapy: Official Journal of the Japan Society of Chemotherapy
https://www.readbyqxmd.com/read/28622957/real-time-polymerase-chain-reaction-based-detection-of-bordetella-pertussis-in-mexican-infants-and-their-contacts-a-3-year-multicenter-study
#8
Alejandra Aquino-Andrade, Gabriel Martínez-Leyva, Jocelin Mérida-Vieyra, Patricia Saltigeral, Antonino Lara, Wendy Domínguez, Silvestre García de la Puente, Agustín De Colsa
OBJECTIVES: To evaluate the usefulness of real-time polymerase chain reaction (RT-PCR) as a diagnostic method for the detection of Bordetella pertussis in hospitalized patients aged <1 year with a clinical diagnosis of whooping cough, as well as to identify the role of household contacts as a source of infection. STUDY DESIGN: This was a prospective, multicenter study of infants aged <1 year who were hospitalized with symptoms suggestive of whooping cough...
June 13, 2017: Journal of Pediatrics
https://www.readbyqxmd.com/read/28621647/timeliness-and-completeness-of-routine-childhood-vaccinations-in-children-by-two-years-of-age-in-alberta-canada
#9
Vineet Saini, Shannon E MacDonald, Deborah A McNeil, Sheila W McDonald, James D Kellner, Sarah A Edwards, Victoria Stagg, Suzanne Tough
OBJECTIVES: Assessing timeliness and completeness of vaccine administration is important for evaluating the effectiveness of immunization programs. Few studies have reported timeliness, particularly in Canada. The objective of this study was to examine timeliness of the receipt of vaccination for each routine childhood recommended vaccine by 24 months of age among children in a community-based pregnancy cohort in Calgary, Alberta. METHODS: Survey data from a community-based pregnancy cohort in Alberta were linked to Public Health vaccination records of children (n = 2763)...
June 16, 2017: Canadian Journal of Public Health. Revue Canadienne de Santé Publique
https://www.readbyqxmd.com/read/28620801/fty720-attenuates-infection-induced-enhancement-of-a%C3%AE-accumulation-in-app-ps1-mice-by-modulating-astrocytic-activation
#10
Róisín M McManus, Orla M Finucane, Mieszko M Wilk, Kingston H G Mills, Marina A Lynch
It is well established that infection has a significant detrimental effect on patients with Alzheimer's disease (AD), accelerating cognitive decline and, even in healthy ageing individuals, increasing amyloid-β (Aβ) accumulation in the brain. In animal models of AD infection can also cause damage, with evidence of increased neuroinflammation, amyloid pathology and deterioration of cognitive function. These changes are against a backdrop of an age- and AD-related increase in susceptibility to infection. Here we set out to determine whether FTY720, a molecule that binds sphingosine-1-phosphate (S1P) receptors and with known immunosuppressant effects mediating its therapeutic action in multiple sclerosis (MS), might modulate the impact of infection in a mouse model of AD...
June 15, 2017: Journal of Neuroimmune Pharmacology: the Official Journal of the Society on NeuroImmune Pharmacology
https://www.readbyqxmd.com/read/28619415/international-travelers-sociodemographic-health-and-travel-characteristics-an-italian-study
#11
Gianmarco Troiano, Astrid Mercone, Alessandra Bagnoli, Nicola Nante
BACKGROUND: Approximately the 8% of travelers requires medical care, with the diagnosis of a vaccine-preventable disease. The aim of our study was to analyze the socio-demographic, health and travel characteristics of the Italian international travelers. METHODS: We conducted a cross sectional study from January 2015 to June 2016, at the Travel Medicine Clinic of Siena, asking the doctor to interview patients who attended the Clinic, recording socio-demographic and travel information, malaria prophylaxis, vaccinations...
March 2017: Annals of Global Health
https://www.readbyqxmd.com/read/28618109/vaccination-timeliness-in-preterm-infants-an-integrative-review-of-the-literature
#12
REVIEW
Helen Sisson, Eric Gardiner, Roger Watson
AIMS AND OBJECTIVES: To take a systematic approach to reviewing the scientific literature examining the timeliness of vaccination in preterm infants and to identify any factors associated with timeliness. BACKGROUND: Preterm infants are vulnerable to infection and guidance advocates they are vaccinated in accordance with their full term peers. Vaccination is well tolerated and protective immune responses are observed, yet some early enquiries suggest that preterm infants experience unwarranted delays...
June 15, 2017: Journal of Clinical Nursing
https://www.readbyqxmd.com/read/28617254/pertussis-in-infants-and-the-resurgence-of-a-vaccine-preventable-disease-what-to-do-commentary
#13
Giorgio Fedele, Paola Stefanelli
Pertussis or whooping cough remains one of the most poorly controlled vaccine-preventable diseases across the world. Universal vaccination has dramatically reduced its incidence but has failed to bring it completely under control. In the last decades, changes in pertussis epidemiology have been noted, likely related to the introduction of acellular pertussis vaccines. Increasing incidence is recorded among adolescents and adults who have become a reservoir for transmission to unimmunized infants, who are at risk of severe disease and death...
April 2017: Annali Dell'Istituto Superiore di Sanità
https://www.readbyqxmd.com/read/28604067/resveratrol-improves-cell-cycle-arrest-in-chronic-prostatitis-rats-by-c-kit-scf-suppression
#14
Yi He, Huizhi Zeng, Yang Yu, Jiashu Zhang, Xiaona Zeng, Fengtao Gong, Qi Liu, Bo Yang
Chronic prostatitis (CP) with complex pathogenesis is difficult for treatment. c-kit has been associated with the control of cell proliferation of prostate cells. This study aims to evaluate the role of resveratrol, an activator of Sirt1, in regulating the expression of c-kit in CP and investigate the consequent effects on cell cycle. Rat model of CP was established through subcutaneous injections of diphtheria-pertussis-tetanus vaccine and subsequently treated with resveratrol. Hematoxylin and eosin staining was performed to identify the histopathological changes in prostates...
June 12, 2017: DNA and Cell Biology
https://www.readbyqxmd.com/read/28602605/vaccination-in-newly-arrived-immigrants-to-the-european-union
#15
Roman Prymula, Jana Shaw, Roman Chlibek, Ingrid Urbancikova, Karolina Prymulova
The challenge of assimilating millions of immigrants in the European region each year presents significant socioeconomic issues. Among them is the threat of vaccine preventable diseases (VPDs) disease transmission within immigrant groups and the broader population given the permeability of nation state borders. A total of 3.8 million people immigrated to the European Union (EU) in 2014, among those were 1.6 million non-EU nationals. While vaccines have markedly reduced the transmission of disease, clusters of under-vaccinated individuals potentiate the rapid transmission of once-eradicated or controlled diseases...
June 8, 2017: Vaccine
https://www.readbyqxmd.com/read/28599792/a-cross-sectional-survey-measuring-sero-incidence-of-pertussis-infection-among-japanese-junior-and-senior-high-school-students-in-2013-and-2014
#16
Hideyuki Ikematsu, Naoki Kawai, Shigehiro Yajima
Pertussis in adolescents has been increasingly documented in recent years, but diagnosis from the clinical symptoms is difficult. Serological diagnosis with IgG antibody to pertussis toxin (IgG PT) is useful for detecting pertussis cases in this population. However, no serological criterion for recent infection has been fully validated and large-scale, longitudinal serological data among Japanese junior and senior high school students are lacking. Paired serum samples of 3243 junior and senior high school students, collected in 2013 and 2014, were analyzed for IgG PT and its relationship to possible risk factors...
June 6, 2017: Vaccine
https://www.readbyqxmd.com/read/28598324/a-case-control-study-to-assess-the-effectiveness-of-pertussis-vaccination-during-pregnancy-on-newborns-valencian-community-spain-1-march-2015-to-29-february-2016
#17
Juan Bellido-Blasco, Silvia Guiral-Rodrigo, Ana Míguez-Santiyán, Antonio Salazar-Cifre, Francisco González-Morán
In the Valencian Community (Spain), the programme of maternal pertussis vaccination during pregnancy started in January 2015. The objective of this study was to estimate in this region the vaccine effectiveness (VE) in protecting newborns against laboratory-confirmed pertussis infection. A matched case-control study was undertaken in the period between 1 March 2015 and 29 February 2016. Twenty-two cases and 66 controls (+/- 15 days of age difference) were included in the study. Cases were non-vaccinated infants < 3 months of age at disease onset testing positive for pertussis by real-time PCR...
June 1, 2017: Euro Surveillance: Bulletin Européen sur les Maladies Transmissibles, European Communicable Disease Bulletin
https://www.readbyqxmd.com/read/28598302/multi-locus-variable-number-tandem-repeat-analysis-of-bordetella-pertussis-isolates-circulating-in-poland-in-the-period-1959-2013
#18
Ewa Mosiej, Katarzyna Krysztopa-Grzybowska, Maciej Polak, Marta Prygiel, Anna Lutyńska
PURPOSE: Despite the long history of pertussis vaccination and high vaccination coverage in Poland and many other developed countries, pertussis incidence rates have increased substantially, making whooping cough one of the most prevalent vaccine-preventable diseases. Among the factors potentially involved in pertussis resurgence, the adaptation of the Bordetella pertussis population to country-specific vaccine-induced immunity through selection of non-vaccine-type strains still needs detailed studies...
June 9, 2017: Journal of Medical Microbiology
https://www.readbyqxmd.com/read/28597954/exposure-to-bordetella-pertussis-adenylate-cyclase-toxin-affects-integrin-mediated-adhesion-and-mechanics-in-alveolar-epithelial-cells
#19
Christelle Angely, Ngoc-Minh Nguyen, Sofia Andre Dias, Emmanuelle Planus, Gabriel Pelle, Bruno Louis, Marcel Filoche, Alexandre Chenal, Daniel Ladant, Daniel Isabey
BACKGROUND: The adenylate cyclase (CyaA) toxin is a major virulent factor of Bordetella pertussis, the causative agent of whooping cough. CyaA toxin is able to invade eukaryotic cells where it produces high levels of cyclic adenosine monophosphate (cAMP) affecting cellular physiology. Whether CyaA toxin can modulate cell matrix adhesion and mechanics of infected cells remains largely unknown. RESULTS: In this study, we use a recently proposed Multiple bond Force Spectroscopy (MFS) with an Atomic Force Microscope to assess the early phase of cell adhesion (maximal detachment and local rupture forces) and cell rigidity (Young's modulus) in alveolar epithelial cells (A549) for toxin exposure <1hour...
June 9, 2017: Biology of the Cell
https://www.readbyqxmd.com/read/28595351/cautious-interpretation-of-optimal-timing-of-maternal-pertussis-immunization
#20
Christiane S Eberhardt, Christophe Combescure, Claire-Anne Siegrist
No abstract text is available yet for this article.
June 8, 2017: Clinical Infectious Diseases: An Official Publication of the Infectious Diseases Society of America
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