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Pertussis

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https://www.readbyqxmd.com/read/29778514/conditional-admission-religious-exemption-type-and-nonmedical-vaccine-exemptions-in-california-before-and-after-a-state-policy-change
#1
Alison M Buttenheim, Malia Jones, Caitlin Mckown, Daniel Salmon, Saad B Omer
Recent measles and pertussis outbreaks in the US have focused national attention on state laws governing exemptions from mandatory vaccines for school entry. After several years of increases in nonmedical exemptions in California, the state assembly passed Assembly Bill 2109 in 2012, making nonmedical exemptions more difficult to obtain by requiring parents to obtain a signature from a health care provider. We used data from the California Department of Public Health to describe changes in the overall prevalence of personal belief exemptions and compositional changes in immunization status for the school years 2012-2013 through 2015-2016...
May 16, 2018: Vaccine
https://www.readbyqxmd.com/read/29776433/bordetella-pertussis-in-children-hospitalized-with-a-respiratory-infection-clinical-characteristics-and-pathogen-detection-in-household-contacts
#2
Juana Del Valle-Mendoza, Wilmer Silva-Caso, Miguel Angel Aguilar-Luis, Cristina Del Valle-Vargas, Erico Cieza-Mora, Johanna Martins-Luna, Ronald Aquino-Ortega, Andrea Silva-Vásquez, Jorge Bazán-Mayra, Pablo Weilg
OBJECTIVE: Describe the prevalence of Bordetella pertussis via PCR in children under 5 years old hospitalized as probable cases of pertussis and report the most common clinical features among them. RESULTS: A positive PCR result for B. pertussis was observed in 20.5% of our samples (18/88), one-third of them were from infants between 2 and 3 months old. The most common symptoms were paroxysms of coughing (88.9%), difficulty breathing (72.2%), cyanosis (77.8%) and fever (50%)...
May 18, 2018: BMC Research Notes
https://www.readbyqxmd.com/read/29776413/the-cxcr4-antagonist-plerixafor-amd3100-promotes-proliferation-of-ewing-sarcoma-cell-lines-in-vitro-and-activates-receptor-tyrosine-kinase-signaling
#3
Philipp Berning, Christiane Schaefer, Dagmar Clemens, Eberhard Korsching, Uta Dirksen, Jenny Potratz
BACKGROUND: The CXCR4 receptor antagonist plerixafor (AMD3100) is raising interest as an anti-cancer agent that disrupts the CXCL12-CXCR4 chemokine - receptor interaction between neoplastic cells and their microenvironment in tumor progression and metastasis. Here, we investigated plerixafor for anti-cancer activity in Ewing sarcoma, a rare and aggressive cancer of bone and soft tissues. METHODS: We used a variety of methods such as cell viability and migration assays, flow cytometry, phospho-tyrosine arrays and western blotting to determine plerixafor effects on five characterized Ewing sarcoma cell lines and a low-passage culture in vitro...
May 18, 2018: Cell Communication and Signaling: CCS
https://www.readbyqxmd.com/read/29774847/genomic-sequencing-of-bordetella-pertussis-for-epidemiology-and-global-surveillance-of-whooping-cough
#4
Valérie Bouchez, Julien Guglielmini, Mélody Dazas, Annie Landier, Julie Toubiana, Sophie Guillot, Alexis Criscuolo, Sylvain Brisse
Bordetella pertussis causes whooping cough, a highly contagious respiratory disease that is reemerging in many world regions. The spread of antigen-deficient strains may threaten acellular vaccine efficacy. Dynamics of strain transmission are poorly defined because of shortcomings in current strain genotyping methods. Our objective was to develop a whole-genome genotyping strategy with sufficient resolution for local epidemiologic questions and sufficient reproducibility to enable international comparisons of clinical isolates...
June 2018: Emerging Infectious Diseases
https://www.readbyqxmd.com/read/29772848/increased-vaccination-coverage-among-adolescents-and-young-adults-in-the-district-of-palermo-as-a-result-of-a-public-health-strategy-to-counteract-an-epidemic-panic
#5
Claudio Costantino, Vincenzo Restivo, Gianmarco Ventura, Claudio D'Angelo, Maria Angela Randazzo, Nicolò Casuccio, Mario Palermo, Alessandra Casuccio, Francesco Vitale
During the summer of 2016 four cases of invasive meningococcal disease in rapid succession among young adults in the district of Palermo, Italy, resulting in one death, were widely reported by local and national mass media. The resultant 'epidemic panic' among the general population overloaded the vaccination units of the Palermo district over the following months. Strategies implemented by the Sicilian and local public health authorities to counteract 'meningitis fear' included the following: (a) extension of active and free-of-charge anti-meningococcal tetravalent vaccination from age class 12⁻18 to 12⁻30 years old; (b) implementation of vaccination units during normal clinic hours in rooms tailored for vaccine administration; (c) development of informative institutional tools and timely communication throughout local mass media to reassure the general population...
May 17, 2018: International Journal of Environmental Research and Public Health
https://www.readbyqxmd.com/read/29771574/is-adding-maternal-vaccination-to-prevent-whooping-cough-cost-effective-in-australia
#6
Laure-Anne Van Bellinghen, Alex Dimitroff, Michael Haberl, Xiao Li, Andrew Manton, Karen Moeremans, Nadia Demarteau
Pertussis or whooping cough, a highly infectious respiratory infection, causes significant morbidity and mortality in infants. In adolescents and adults, pertussis presents with atypical symptoms often resulting in under-diagnosis and under-reporting, increasing the risk of transmission to more vulnerable groups. Maternal vaccination against pertussis protects mothers and newborns. This evaluation assessed the cost-effectiveness of adding maternal dTpa (reduced antigen diphtheria, Tetanus, acellular pertussis) vaccination to the 2016 nationally-funded pertussis program (DTPa [Diphtheria, Tetanus, acellular Pertussis] at 2, 4, 6, 18 months, 4 years and dTpa at 12-13 years) in Australia...
May 17, 2018: Human Vaccines & Immunotherapeutics
https://www.readbyqxmd.com/read/29771235/bordetella-pertussis-population-dynamics-and-phylogeny-in-japan-after-adoption-of-acellular-pertussis-vaccines
#7
Aldert Zomer, Nao Otsuka, Yukihiro Hiramatsu, Kazunari Kamachi, Naoko Nishimura, Takao Ozaki, Jan Poolman, Jeroen Geurtsen
Bordetella pertussis, the causative agent of whooping cough, has experienced a resurgence in the past 15 years, despite the existence of both whole-cell and acellular vaccines. Here, we performed whole genome sequencing analysis of 149 clinical strains, provided by the National Institute of Infectious Diseases (NIID), Japan, isolated in 1982-2014, after Japan became the first country to adopt acellular vaccines against B. pertussis. Additionally, we sequenced 39 strains provided by the Konan Kosei Hospital in Aichi prefecture, Japan, isolated in 2008-2013...
May 17, 2018: Microbial Genomics
https://www.readbyqxmd.com/read/29770078/evaluating-the-timeliness-of-reporting-in-a-first-nations-communicable-diseases-program
#8
A Lam, S Woods, N Ndubuka
Background: Timely reporting of communicable diseases is necessary to enable a prompt response to mitigate and control outbreaks. This is especially true among First Nations communities due to a number of factors, including unique social determinants of health, which can contribute to rapid disease transmission. Objective: To assess the timeliness of reporting for 12 notifiable communicable diseases in the Northern Inter-Tribal Health Authority, which includes 33 First Nations on-reserve communities in Northern Saskatchewan, Canada, and to assess whether there were differences in reporting times depending on degree of remoteness of community, season or year...
June 1, 2017: Canada Communicable Disease Report, Relevé des Maladies Transmissibles Au Canada
https://www.readbyqxmd.com/read/29765775/potential-impact-of-introducing-the-pneumococcal-conjugate-vaccine-into-national-immunisation-programmes-an-economic-epidemiological-analysis-using-data-from-india
#9
Itamar Megiddo, Eili Klein, Ramanan Laxminarayan
Pneumococcal pneumonia causes an estimated 105 000 child deaths in India annually. The planned introduction of the serotype-based pneumococcal conjugate vaccine (PCV) is expected to avert child deaths, but the high cost of PCV relative to current vaccines provided under the Universal Immunization Programme has been a concern. Cost-effectiveness studies from high-income countries are not readily comparable because of differences in the distribution of prevalent serotypes, population and health systems. We extended IndiaSim, our agent-based simulation model representative of the Indian population and health system, to model the dynamics of Streptococcus pneumoniae ...
2018: BMJ Global Health
https://www.readbyqxmd.com/read/29765373/compartmentalized-cyclic-amp-production-by-the-bordetella-pertussis-and-bacillus-anthracis-adenylate-cyclase-toxins-differentially-affects-the-immune-synapse-in-t-lymphocytes
#10
Vijay B Arumugham, Cristina Ulivieri, Anna Onnis, Francesca Finetti, Fiorella Tonello, Daniel Ladant, Cosima T Baldari
A central feature of the immune synapse (IS) is the tight compartmentalization of membrane receptors and signaling mediators that is functional for its ability to coordinate T cell activation. Second messengers centrally implicated in this process, such as Ca2+ and diacyl glycerol, also undergo compartmentalization at the IS. Current evidence suggests a more complex scenario for cyclic AMP (cAMP), which acts both as positive and as negative regulator of T-cell antigen receptor (TCR) signaling and which, as such, must be subjected to a tight spatiotemporal control to allow for signaling at the IS...
2018: Frontiers in Immunology
https://www.readbyqxmd.com/read/29762363/immunogenicity-and-safety-of-primary-and-booster-vaccinations-of-a-fully-liquid-dtap-ipv-hb-prp-t-hexavalent-vaccine-in-healthy-infants-and-toddlers-in-germany-and-the-czech-republic
#11
Roman Prymula, Dorothee Kieninger, Emmanuel Feroldi, Emilia Jordanov, Siham B'Chir, Xavier DaCosta
BACKGROUND: To support a fully liquid, diphtheria (D)-tetanus (T)-acellular pertussis (aP)-inactivated poliovirus (IPV)-hepatitis B (HB)-Haemophilus influenzae b (PRP-T) vaccine in Europe using a 2, 3, 4 month primary series and a booster at 11 to 15 months of age. METHODS: Phase III, randomized, observer-blind studies in Germany and the Czech Republic. Participants who had not received HB vaccine were randomized to a 2, 3, 4 month primary series of DTaP-IPV-HB-PRP-T (Group 1; N=266) or a reconstituted DTaPHB-IPV//PRP-T comparator (Group 2; N=263) and a booster of the same vaccine...
May 14, 2018: Pediatric Infectious Disease Journal
https://www.readbyqxmd.com/read/29761340/reduction-of-direct-health-costs-associated-with-pertussis-vaccination-with-acellular-vaccines-in-children-aged-0-9-years-with-pertussis-in-catalonia-spain
#12
Pedro Plans-Rubió, Encarna Navas, Pere Godoy, Gloria Carmona, Angela Domínguez, Mireia Jané, Carmen Muñoz-Almagro, Pedro Brotons
OBJECTIVES: The aim of this study was to assess direct health costs in children with pertussis aged 0-9 years who were vaccinated, partially vaccinated, and unvaccinated during childhood, and to assess the association between pertussis costs and pertussis vaccination in Catalonia (Spain) in 2012-2013. METHODS: Direct healthcare costs included pertussis treatment, pertussis detection, and preventive chemotherapy of contacts. Pertussis patients were considered vaccinated when they had received 4-5 doses, and unvaccinated or partially vaccinated when they had received 0-3 doses of vaccine...
May 14, 2018: PharmacoEconomics Open
https://www.readbyqxmd.com/read/29753630/comparison-of-two-training-methods-in-community-pharmacy-project-vaccinate
#13
James L Lin, Jennifer L Bacci, Marci J Reynolds, Yushi Li, Rachel G Firebaugh, Peggy S Odegard
OBJECTIVE: To compare the impact of a whole-staff training strategy to a train-the-trainer strategy on 1) the number of influenza, pneumococcal, herpes zoster, and pertussis vaccines administered by community pharmacists to adults; 2) staff confidence; and 3) fidelity to the intervention. SETTING: Eight Quality Food Centers (QFC) Pharmacies in Seattle, Washington. PRACTICE DESCRIPTION: QFC Pharmacy is a grocery store division of The Kroger Co...
May 9, 2018: Journal of the American Pharmacists Association: JAPhA
https://www.readbyqxmd.com/read/29752131/effectiveness-of-the-dtpa-hbv-ipv-hib-vaccine-against-invasive-haemophilus-influenzae-type-b-disease-in-the-netherlands-2003-16-a-case-control-study
#14
Susana Monge, Susan Jm Hahné, Hester E de Melker, Elisabeth Am Sanders, Arie van der Ende, Mirjam J Knol
BACKGROUND: In 2016, an increase in invasive Haemophilus influenzae serotype b (Hib) disease was reported in the Netherlands in children younger than 5 years, which coincided with the introduction of the hexavalent diphtheria, tetanus, and acellular pertussis-hepatitis B virus-inactivated polio virus/Hib vaccine (DTPa-HBV-IPV/Hib) from 2011 onwards. We aimed to estimate the effectiveness of the hexavalent vaccine to assess whether this increase could be explained by decreasing effectiveness...
May 8, 2018: Lancet Infectious Diseases
https://www.readbyqxmd.com/read/29751196/the-significance-role-of-regulatory-t-cells-in-the-persistence-of-infections-by-intracellular-bacteria
#15
REVIEW
Parisa Sabbagh, Ahmad Karkhah, Hamid Reza Nouri, Mostafa Javanian, Soheil Ebrahimpour
Regulatory T cells (Treg cells), are considered as effective immune cells playing a key role in immune response during cancers, autoimmune and infectious diseases. Regulatory T lymphocytes are divided into two main subgroups: natural Treg cells that generated during maturation in the thymus and have the suppressive activity that is critical for the establishment and maintenance of homeostasis in the body and induced Treg cells (iTreg) that are originated from naive T cells following the self-antigen recognition...
May 8, 2018: Infection, Genetics and Evolution
https://www.readbyqxmd.com/read/29749388/retraction-murine-hypothalamic-destruction-with-vascular-cell-apoptosis-subsequent-to-combined-administration-of-human-papilloma-virus-vaccine-and-pertussis-toxin
#16
Satoko Aratani, Hidetoshi Fujita, Yoshiyuki Kuroiwa, Chie Usui, Shumpei Yokota, Ikuro Nakamura, Kusuki Nishioka, Toshihiro Nakajima
This corrects the article DOI: 10.1038/srep36943.
May 11, 2018: Scientific Reports
https://www.readbyqxmd.com/read/29748940/surveillance-of-adverse-events-following-immunization-in-oman-2006-2015
#17
Prakash K Patel, Bader Al-Rawahi, Athari Al-Jawari, Idris Al-Abaidani, Seif Al-Abri
Background: In 1996, Oman launched its surveillance programme for adverse events following immunization (AEFI) to address vaccine safety concerns. In 2010, an analysis of surveillance activities for AEFI was done for 10 years (1996-2005). Objectives: The main objective of the study was to describe the trend of AEFI over the 10-year period, 2006-2015, and compare the findings with a previous report in Oman and reports from other countries. Methods: A descriptive record-based review of AEFI was carried out using the national AEFI surveillance database for the study period, 2006-2015...
May 3, 2018: Eastern Mediterranean Health Journal, la Revue de Santé de la Méditerranée Orientale
https://www.readbyqxmd.com/read/29747736/infections-in-pregnancy-and-the-role-of-vaccines
#18
REVIEW
Kimberly B Fortner, Claudia Nieuwoudt, Callie F Reeder, Geeta K Swamy
Pregnant women are at risk for infection and may have significant morbidity or mortality. Influenza, pertussis, zika, and cytomegalovirus produce mild or asymptomatic illness in the mother, but have profound implications for her fetus. Maternal immunization can prevent or mitigate infections in pregnant women and their infants. The Advisory Committee of Immunization Practices recommends 2 vaccines during pregnancy: inactivated influenza, and tetanus toxoid, reduced diphtheria toxoid, and acellular pertussis during pregnancy...
June 2018: Obstetrics and Gynecology Clinics of North America
https://www.readbyqxmd.com/read/29744062/severe-pertussis-in-a-young-infant-due-to-household-transmission-the-needs-of-pertussis-vaccination-boosters-in-japan
#19
Daiji Takajo, Shigeaki Nonoyama
Household is responsible for a large percentage of pertussis infection in young infants. Japanese vaccine recommendation committee does not recommend any boosters for teens and pregnant women. Because of its high vaccine effectiveness, introduction of vaccination for pregnant women is high priority to prevent pertussis infection in young infants.
May 2018: Clinical Case Reports
https://www.readbyqxmd.com/read/29739922/bordetella-pertussis-isolates-vary-in-their-interactions-with-human-complement-components
#20
Charlotte Brookes, Irene Freire-Martin, Breeze Cavell, Frances Alexander, Stephen Taylor, Ruby Persaud, Norman Fry, Andrew Preston, Dimitri Diavatopoulos, Andrew Gorringe
Whooping cough is a re-emerging respiratory tract infection. It has become clear that there is a need for better understanding of protective immune responses and variation between Bordetella pertussis strains to aid the development of improved vaccines. In order to survive in the host, B. pertussis has evolved mechanisms to evade complement-mediated killing, including the ability to bind complement-regulatory proteins. Here we evaluate the variation in interactions with the complement system among recently isolated strains...
May 9, 2018: Emerging Microbes & Infections
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