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"Knowledge management"

Alessandra Livigni, Laura O'Hara, Marta E Polak, Tim Angus, Derek W Wright, Lee B Smith, Tom C Freeman
A major endeavor of systems biology is the construction of graphical and computational models of biological pathways as a means to better understand their structure and function. Here, we present a protocol for a biologist-friendly graphical modeling scheme that facilitates the construction of detailed network diagrams, summarizing the components of a biological pathway (such as proteins and biochemicals) and illustrating how they interact. These diagrams can then be used to simulate activity flow through a pathway, thereby modeling its dynamic behavior...
April 2018: Nature Protocols
Alana Grech, Emmanuel Hanert, Len McKenzie, Michael Rasheed, Christopher Thomas, Samantha Tol, Mingzhu Wang, Michelle Waycott, Jolan Wolter, Rob Coles
The rate of exchange, or connectivity, among populations effects their ability to recover after disturbance events. However, there is limited information on the extent to which populations are connected or how multiple disturbances affect connectivity, especially in coastal and marine ecosystems. We used network analysis and the outputs of a biophysical model to measure potential functional connectivity and predict the impact of multiple disturbances on seagrasses in the central Great Barrier Reef World Heritage Area (GBRWHA), Australia...
March 15, 2018: Global Change Biology
Naowarut Charoenca, Nipapun Kungskulniti, Duangkamon Sritabutra, Siriwan Pitayarangsarit, Stephen L Hamann
Background: Because implementation of the Framework Convention on Tobacco Control (FCTC), a World Health Organization (WHO) treaty to reduce tobacco use, is an important goal of the 2015 United Nations Sustainable Development Goals (SDGs) and Thailand has sought to fully comply with all its articles, a multiperspective assessment was developed to ensure that any gaps in compliance with FCTC provisions were identified and addressed. Method: One assessment mechanism of this multicomponent assessment was the development by experts and use by stakeholders of a 3-tiered rating of all major provisions of the main articles of the FCTC...
2018: Tobacco Use Insights
Christopher J Koenig, Matthew Wenger, Glenn D Graham, Steven Asch, Catherine Rongey
Introduction Consultations are the traditional method of communication between generalist and specialist providers managing patients with specialty care needs. Traditional written consultations have limitations, including inadequate clinical information and inappropriate, or unclear consultation questions. Teleconsultations minimize these limitations through real-time communication between generalist and specialist providers to actively manage professional knowledge boundaries about specialty care problems...
January 1, 2018: Journal of Telemedicine and Telecare
Y Fu, G Yu, E McNichol, K Marczewski, S J Closs
BACKGROUND: Self-management is recommended for patients with chronic back pain. Health professionals' support for self-management can be more effective when working in partnership with patients. The aim of this study was to investigate the associations between patient-professional partnerships and the self-management of chronic back pain. METHODS: An explanatory sequential mixed methods study was undertaken. Adults with chronic back pain referred to pain management clinics participated at baseline and three-month follow-up...
March 5, 2018: European Journal of Pain: EJP
Justin Bussery, Leslie-Alexandre Denis, Benjamin Guillon, Pengfeï Liu, Gino Marchetti, Ghita Rahal
We describe the genesis, design and evolution of a computing platform designed and built to improve the success rate of biomedical translational research. The eTRIKS project platform was developed with the aim of building a platform that can securely host heterogeneous types of data and provide an optimal environment to run tranSMART analytical applications. Many types of data can now be hosted, including multi-OMICS data, preclinical laboratory data and clinical information, including longitudinal data sets...
February 13, 2018: Computers in Biology and Medicine
Tudor I Oprea, Cristian G Bologa, Søren Brunak, Allen Campbell, Gregory N Gan, Anna Gaulton, Shawn M Gomez, Rajarshi Guha, Anne Hersey, Jayme Holmes, Ajit Jadhav, Lars Juhl Jensen, Gary L Johnson, Anneli Karlson, Andrew R Leach, Avi Ma'ayan, Anna Malovannaya, Subramani Mani, Stephen L Mathias, Michael T McManus, Terrence F Meehan, Christian von Mering, Daniel Muthas, Dac-Trung Nguyen, John P Overington, George Papadatos, Jun Qin, Christian Reich, Bryan L Roth, Stephan C Schürer, Anton Simeonov, Larry A Sklar, Noel Southall, Susumu Tomita, Ilinca Tudose, Oleg Ursu, Dušica Vidovic, Anna Waller, David Westergaard, Jeremy J Yang, Gergely Zahoránszky-Köhalmi
A large proportion of biomedical research and the development of therapeutics is focused on a small fraction of the human genome. In a strategic effort to map the knowledge gaps around proteins encoded by the human genome and to promote the exploration of currently understudied, but potentially druggable, proteins, the US National Institutes of Health launched the Illuminating the Druggable Genome (IDG) initiative in 2014. In this article, we discuss how the systematic collection and processing of a wide array of genomic, proteomic, chemical and disease-related resource data by the IDG Knowledge Management Center have enabled the development of evidence-based criteria for tracking the target development level (TDL) of human proteins, which indicates a substantial knowledge deficit for approximately two out of five proteins in the human proteome...
February 23, 2018: Nature Reviews. Drug Discovery
Marcelo D Agostino, Felipe Medina Mejía, Myrna Martí, David Novillo-Ortiz, Flavio Hazrum, Federico G de Cosío
OBJECTIVE: The objectives of this study were to: 1) raise awareness of the volume of quality health information on the Internet; 2) explore perceptions of information professionals with regard to the use of qualified sources for health decision-making; and 3) make recommendations that facilitate strengthening health worker capacities and institutional competencies related to digital literacy. METHODS: A non-experimental, descriptive cross-sectional study was conducted with a non-probability sample of 32 information professionals from nine countries...
February 19, 2018: Revista Panamericana de Salud Pública, Pan American Journal of Public Health
Freida Ozavize Ayodele, Liu Yao, Hasnah Haron
In the management academic research, academic advancement, job security, and the securing of research funds at one's university are judged mainly by one's output of publications in high impact journals. With bogus resumes filled with published journal articles, universities and other allied institutions are keen to recruit or sustain the appointment of such academics. This often places undue pressure on aspiring academics and on those already recruited to engage in research misconduct which often leads to research integrity...
February 13, 2018: Science and Engineering Ethics
Naeem Uddin Mian, Muhammad Adeel Alvi, Mariam Zahid Malik, Sarosh Iqbal, Rubeena Zakar, Muhammad Zakria Zakar, Shehzad Hussain Awan, Faryal Shahid, Muhammad Ashraf Chaudhry, Florian Fischer
BACKGROUND: South Asia is experiencing a dismal state of maternal and newborn health (MNH) as the region has been falling behind in reducing the levels of maternal and neonatal mortality. Most of the efforts are focused on enhancing coverage of MNH services; however, quality remains a serious concern if the region is to achieve expected outcomes in terms of standardised MNH services within healthcare delivery systems. This research consists of a review of South Asian quality improvement (QI) approaches/interventions, specifically implemented for MNH improvement...
February 6, 2018: Globalization and Health
E Andrew Balas, Wendy W Chapman
New scientific knowledge and innovation are often slow to disseminate. In other cases, providers rush into adopting what appears to be a clinically relevant innovation, based on a single clinical trial. In reality, adopting innovations without appropriate translation and repeated testing of practical application is problematic. In this article we provide examples of clinical innovations (for example, tight glucose control in critically ill patients) that were adopted inappropriately and that caused what we term a malfunction...
February 2018: Health Affairs
Mary Ann Cooney, Michael F Iademarco, Monica Huang, William R MacKenzie, Arthur J Davidson
At the intersection of new technology advancements, ever-changing health policy, and fiscal constraints, public health agencies seek to leverage modern technical innovations and benefit from a more comprehensive and cooperative approach to transforming public health, health care, and other data into action. State health agencies recognized a way to advance population health was to integrate public health with clinical health data through electronic infectious disease case reporting. The Public Health Community Platform (PHCP) concept of bidirectional data flow and knowledge management became the foundation to build a cloud-based system connecting electronic health records to public health data for a select initial set of notifiable conditions...
March 2018: Journal of Public Health Management and Practice: JPHMP
Viktor Senderov, Kiril Simov, Nico Franz, Pavel Stoev, Terry Catapano, Donat Agosti, Guido Sautter, Robert A Morris, Lyubomir Penev
BACKGROUND: The biodiversity domain, and in particular biological taxonomy, is moving in the direction of semantization of its research outputs. The present work introduces OpenBiodiv-O, the ontology that serves as the basis of the OpenBiodiv Knowledge Management System. Our intent is to provide an ontology that fills the gaps between ontologies for biodiversity resources, such as DarwinCore-based ontologies, and semantic publishing ontologies, such as the SPAR Ontologies. We bridge this gap by providing an ontology focusing on biological taxonomy...
January 18, 2018: Journal of Biomedical Semantics
Larry W Swanson
The fourth edition (following editions in 1992, 1998, 2004) of Brain maps: structure of the rat brain is presented here as an open access internet resource for the neuroscience community. One new feature is a set of 10 hierarchical nomenclature tables that define and describe all parts of the rat nervous system within the framework of a strictly topographic system devised previously for the human nervous system. These tables constitute a global ontology for knowledge management systems dealing with neural circuitry...
December 26, 2017: Journal of Comparative Neurology
Matina Ghasemi, Mazyar Ghadiri Nejad, Kemal Bagzibagli
Background: By considering innovation as a new project in hospitals, all the project management's standard steps should be followed in execution. This study investigated the validation of a new set of measures in terms of providing a procedure for knowledge management-oriented innovation that enriches the hospital management system. Methods: The relation between innovation and all the knowledge management areas, as the main constructs of project management, was illustrated by referring to project management standard steps and previous studies...
December 2017: Iranian Journal of Public Health
Leila Shahmoradi, Reza Safadari, Worku Jimma
Background: Healthcare is a knowledge driven process and thus knowledge management and the tools to manage knowledge in healthcare sector are gaining attention. The aim of this systematic review is to investigate knowledge management implementation and knowledge management tools used in healthcare for informed decision making. Methods: Three databases, two journals websites and Google Scholar were used as sources for the review. The key terms used to search relevant articles include: "Healthcare and Knowledge Management"; "Knowledge Management Tools in Healthcare" and "Community of Practices in healthcare"...
September 2017: Ethiopian Journal of Health Sciences
Ian Harrow, Ernesto Jiménez-Ruiz, Andrea Splendiani, Martin Romacker, Peter Woollard, Scott Markel, Yasmin Alam-Faruque, Martin Koch, James Malone, Arild Waaler
BACKGROUND: The disease and phenotype track was designed to evaluate the relative performance of ontology matching systems that generate mappings between source ontologies. Disease and phenotype ontologies are important for applications such as data mining, data integration and knowledge management to support translational science in drug discovery and understanding the genetics of disease. RESULTS: Eleven systems (out of 21 OAEI participating systems) were able to cope with at least one of the tasks in the Disease and Phenotype track...
December 2, 2017: Journal of Biomedical Semantics
Taro Shimizu, Takaaki Nemoto, Yasuharu Tokuda
Clinical evidence has indicated the effectiveness of computer-based systems for preventing and reducing diagnostic errors. Our study aimed to evaluate the effectiveness of UpToDate, a computer-based clinical knowledge management system, for reducing diagnostic errors. We retrospectively identified 100 patients who visited an outpatient department in a community-based hospital from July 2014 to June 2015. Fifty patients (exposure group) were seen by UpToDate-equipped physicians and another 50 (control group) were seen by UpToDate-unequipped physicians...
January 2018: International Journal of Medical Informatics
Gerd Kempermann
The Cynefin scheme is a concept of knowledge management, originally devised to support decision making in management, but more generally applicable to situations, in which complexity challenges the quality of insight, prediction, and decision. Despite the fact that life itself, and especially the brain and its diseases, are complex to the extent that complexity could be considered their cardinal feature, complex problems in biomedicine are often treated as if they were actually not more than the complicated sum of solvable sub-problems...
2017: Frontiers in Neuroscience
Bertram Geisel, Thomas Lampert, Susanne Wurm, Ute Thyen
Demographic and social transformation occur due to changes in the structure of the population and employment especially of women, increasing cultural diversity, unequal educational opportunities for children and adolescents, and regional variation in the provision of services. Meeting the challenges requires flexible, responsive and integrated social and health care systems that allow participation of individuals and groups concerned and recognition of their views and perspectives. Health monitoring and knowledge management is adjusted to the needs of the population and transfers high quality, evidence-based knowledge into all policy areas (health in all policies strategy)...
November 2017: Das Gesundheitswesen
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