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https://www.readbyqxmd.com/read/28196198/en-face-doppler-optical-coherence-tomography-measurement-of-total-retinal-blood-flow-in-diabetic-retinopathy-and-diabetic-macular-edema
#1
ByungKun Lee, Eduardo A Novais, Nadia K Waheed, Mehreen Adhi, Talisa E de Carlo, Emily D Cole, Eric M Moult, WooJhon Choi, Mark Lane, Caroline R Baumal, Jay S Duker, James G Fujimoto
Importance: Alterations in ocular blood flow play an important role in the pathogenesis and progression of diabetic retinopathy (DR). However, the measurement of retinal blood flow in clinical studies has been challenging. En face Doppler optical coherence tomography (OCT) provides an effective method for measuring total retinal blood flow (TRBF) in the clinic. Objective: To investigate TRBF in eyes with DR of varying severity, with or without diabetic macular edema (DME), using en face Doppler OCT...
February 9, 2017: JAMA Ophthalmology
https://www.readbyqxmd.com/read/28181367/periocular-breast-carcinoma-metastases-correlation-of-clinical-radiologic-and-histopathologic-features
#2
Natalie Homer, Frederick A Jakobiec, Anna Stagner, Mary Elizabeth Cunnane, Suzanne K Freitag, Aaron Fay, Michael K Yoon
IMPORTANCE: To describe presenting patterns of breast cancer metastases to the orbit and eyelids BACKGROUND: To provide clinical, radiographic, and pathologic correlations of breast metastases to the orbit or eyelids and evaluate radiographic volumetric orbital changes DESIGN: Retrospective review in an academic center PARTICIPANTS: Ten female patients with periocular metastatic breast carcinoma who were seen at the Massachusetts Eye and Ear Infirmary Oculoplastics Clinic METHODS: Retrospective review of patient records, imaging and pathology findings...
February 9, 2017: Clinical & Experimental Ophthalmology
https://www.readbyqxmd.com/read/28153439/validation-of-the-retinal-detachment-after-open-globe-injury-rd-ogi-score-as-an-effective-tool-for-predicting-retinal-detachment
#3
Katarzyna Brodowska, Tomasz P Stryjewski, Evangelia Papavasileiou, Yewlin E Chee, Dean Eliott
PURPOSE: The Retinal Detachment after Open Globe Injury (RD-OGI) Score is a clinical prediction model that was developed at the Massachusetts Eye and Ear Infirmary to predict the risk of retinal detachment (RD) after open globe injury (OGI). This study sought to validate the RD-OGI Score in an independent cohort of patients. DESIGN: Retrospective cohort study. PARTICIPANTS: The predictive value of the RD-OGI Score was evaluated by comparing the original RD-OGI Scores of 893 eyes with OGI that presented between 1999 and 2011 (the derivation cohort) with 184 eyes with OGI that presented from January 1, 2012, to January 31, 2014 (the validation cohort)...
January 30, 2017: Ophthalmology
https://www.readbyqxmd.com/read/28006052/association-of-low-vitamin-d-levels-with-noninfectious-anterior-uveitis
#4
Lindsay A Grotting, Samaneh Davoudi, Deanna Palenzuela, George N Papaliodis, Lucia Sobrin
Importance: Vitamin D plays an important role in both the innate and adaptive immune systems. It has been shown to contribute to the etiology of T-cell-mediated autoimmune diseases through the upregulation of type 2 anti-inflammatory T helper cells and the suppression of type 1 T helper cells. Noninfectious uveitis is postulated to be caused by immune dysfunction. Objective: To determine whether there is an association between vitamin D levels and noninfectious anterior uveitis...
December 22, 2016: JAMA Ophthalmology
https://www.readbyqxmd.com/read/27913719/surgical-site-infections-in-major-head-and-neck-surgeries-involving-pedicled-flap-reconstruction
#5
Neerav Goyal, Bharat B Yarlagadda, Daniel G Deschler, Kevin S Emerick, Derrick T Lin, Debbie L Rich, James W Rocco, Marlene L Durand
OBJECTIVE: To evaluate surgical site infections (SSI) after pedicled reconstruction in head and neck surgery. METHODS: Records of patients with pedicled flap reconstructions between 2009 and 2014 at Massachusetts Eye and Ear were reviewed. Onset of SSI or fistula ≤30 days postoperatively was noted. A free flap cohort was reviewed for comparison. RESULTS: Two hundred and eight pedicled reconstructions were performed for cancer (83%), osteoradionecrosis (7%), and other reasons (10%)...
January 2017: Annals of Otology, Rhinology, and Laryngology
https://www.readbyqxmd.com/read/27754769/treatment-of-serpiginous-choroiditis-with-chlorambucil-a-report-of-17-patients
#6
Nazanin Ebrahimiadib, Bobeck S Modjtahedi, Samaneh Davoudi, C Stephen Foster
PURPOSE: To evaluate the efficacy of chlorambucil in the treatment of serpiginous choroiditis. METHODS: Patient records from the Massachusetts Eye Research and Surgery Institution (MERSI) were reviewed from over the past 10 years. In total, 17 patients with the diagnosis of serpiginous choroiditis treated with chlorambucil were identified. QuantiFERON gold was negative in all of them. Chlorambucil was started at 0.15 mg/kg and dosage was titrated up using weekly white blood cell (WBC) count to achieve a target cell number of 3...
October 18, 2016: Ocular Immunology and Inflammation
https://www.readbyqxmd.com/read/27749618/clinical-presentation-and-bacteriology-of-eyebrow-infections-the-massachusetts-eye-and-ear-infirmary-experience-2008-2015
#7
Anaïs L Carniciu, Jonathan Chou, Ilya Leskov, Suzanne K Freitag
PURPOSE: This study retrospectively reviews preseptal cellulitis and abscesses involving the eyebrow to elucidate the bacteriology and potential causative factors. METHODS: A retrospective chart review was conducted to identify patients who had been diagnosed with preseptal cellulitis or abscess involving the eyebrow at the Massachusetts Eye and Ear Infirmary between 2008 and 2015. Demographic, clinical, and microbiological data were collected. RESULTS: Eighty patients with eyebrow infections were identified, of whom 49 (61...
October 5, 2016: Ophthalmic Plastic and Reconstructive Surgery
https://www.readbyqxmd.com/read/27681002/infliximab-therapy-in-patients-with-noninfectious-intermediate-uveitis-resistant-to-conventional-immunomodulatory-therapy
#8
Arash Maleki, Haitham F Sahawneh, Lina Ma, Halea Meese, Yuchen He, C Stephen Foster
PURPOSE: To examine the efficacy and safety of infliximab therapy in the treatment for noninfectious intermediate uveitis resistant to conventional immunomodulatory therapy. METHODS: Forty-four eyes of 23 patients with resistant noninfectious intermediate uveitis who were treated with infliximab infusions for a minimum period of 3 months were included. Demographic data, clinical data, and fluorescein angiography and optical coherence tomography findings were collected from the Massachusetts Eye Research and Surgery Institution database between August 2005 and February 2014...
September 27, 2016: Retina
https://www.readbyqxmd.com/read/27626471/evaluation-of-static-and-dynamic-balance-in-athletes-with-anterior-cruciate-ligament-injury-a-controlled-study
#9
Tiago Lazzaretti Fernandes, Ellen Cristina Rodrigues Felix, Felipe Bessa, Natália Ms Luna, Dai Sugimoto, Júlia Maria D'Andrea Greve, Arnaldo José Hernandez
OBJECTIVES: Anterior cruciate ligament injury leads to adaptive responses to maintain postural control. However, there is no consensus regarding whether leg dominance also affects postural control in athletes with anterior cruciate ligament injury. The purpose of this study was to evaluate dynamic and static postural control among athletes with and without anterior cruciate ligament injury to the dominant leg. METHODS: Twenty-eight athletes, twenty-one males and seven females aged 15-45 years, were allocated to one of two groups: the anterior cruciate ligament injury group (26±3 years) or the control group without anterior cruciate ligament injury (25±6...
August 2016: Clinics
https://www.readbyqxmd.com/read/27608418/post-hybrid-cochlear-implant-hearing-loss-and-endolymphatic-hydrops
#10
Akira Ishiyama, Joni Doherty, Gail Ishiyama, Alicia M Quesnel, Ivan Lopez, Fred H Linthicum
OBJECTIVE: To evaluate for potential causes of delayed loss of residual hearing that variably occurs with hybrid cochlear implants. STUDY DESIGN: Histopathological evaluation of 29 human temporal bone (HTB) with cochlear implant (CI). SETTING: The Neurotology and House HTB Laboratory of UCLA (House-UCLA). SUBJECTS AND METHODS: HTB from CI patients from the House-UCLA HTB Laboratory (n = 28) and one courtesy of Massachusetts Eye and Ear Infirmary (MEEI)...
December 2016: Otology & Neurotology
https://www.readbyqxmd.com/read/27565392/outcomes-in-endoscopic-ear-surgery
#11
REVIEW
Ruwan Kiringoda, Elliott D Kozin, Daniel J Lee
Endoscopic ear surgery (EES) provides several advantages compared with traditional binocular microscopy, including a wide-field view, improved resolution with high magnification, and visual access to hidden corridors of the middle ear. Although binocular microscopic-assisted surgical techniques remain the gold standard for most otologists, EES is slowly emerging as a viable alternative for performing otologic surgery at several centers in the United States and abroad. In this review, we evaluate the current body of literature regarding EES outcomes, summarize our EES outcomes at the Massachusetts Eye and Ear Infirmary, and compare these results with data for microscopic-assisted otologic surgery...
October 2016: Otolaryngologic Clinics of North America
https://www.readbyqxmd.com/read/27538795/long-term-visual-outcomes-and-complications-of-boston-keratoprosthesis-type-ii-implantation
#12
Ramon Lee, Ziad Khoueir, Edem Tsikata, James Chodosh, Claes H Dohlman, Teresa C Chen
PURPOSE: To report the long-term visual outcomes and complications after Boston keratoprosthesis type II implantation in the largest single-center case series with the longest average follow-up. DESIGN: Retrospective review of consecutive clinical case series. PARTICIPANTS: Between January 1992 and April 2015 at the Massachusetts Eye and Ear Infirmary, 48 eyes of 44 patients had keratoprosthesis type II implanted by 2 surgeons (C.H.D. and J...
January 2017: Ophthalmology
https://www.readbyqxmd.com/read/27448925/endophthalmitis-after-intravitreal-injections-in-patients-with-self-reported-iodine-allergy
#13
Bobeck S Modjtahedi, Tavé van Zyl, Hemang K Pandya, Robert E Leonard, Dean Eliott
PURPOSE: To present cases of endophthalmitis following intravitreal injections where povidone-iodine (PI) was not used as part of the surgical preparation. DESIGN: Retrospective case series. METHODS: All cases of presumed injection-related endophthalmitis presenting to the Massachusetts Eye and Ear Infirmary between June 2008 and November 2014 and Dean McGee Eye Institute between January 2010 and January 2015 were identified. Patients who did not receive PI preparation owing to documented self-reported allergy to iodine, iodine-containing contrast material, or shellfish were identified and their injection histories and clinical courses reviewed...
October 2016: American Journal of Ophthalmology
https://www.readbyqxmd.com/read/27362884/successful-treatment-strategies-in-granulomatosis-with-polyangiitis-associated-peripheral-ulcerative-keratitis
#14
Nazanin Ebrahimiadib, Bobeck S Modjtahedi, Ramak Roohipoor, Stephen D Anesi, C Stephen Foster
PURPOSE: Management of granulomatosis with polyangiitis (GPA)-associated peripheral ulcerative keratitis (PUK) is challenging and lacks definite guidelines. We aimed to summarize our treatment and outcome experience with patients with GPA-PUK. METHODS: The Massachusetts Eye Research and Surgery Institution patient database was searched from 2005 to 2015 to identify patients with diagnosis of PUK who suffered from GPA. Individual patient histories were examined, and treatment strategies and outcomes were summarized...
November 2016: Cornea
https://www.readbyqxmd.com/read/27356238/modified-best-practice-algorithm-to-reduce-the-number-of-postoperative-videofluoroscopic-swallow-studies-in-patients-with-type-1-laryngeal-cleft-repair
#15
Carissa Wentland, Cheryl Hersh, Sarah Sally, M Shannon Fracchia, Steven Hardy, Bob Liu, Jordan A Garcia, Christopher J Hartnick
IMPORTANCE: There is no consensus as to the timing of videofluoroscopic swallow studies (VFSSs) in determining resolving aspiration after laryngeal cleft repair. There is a growing literature on the effect of radiation exposure in children. OBJECTIVE: To modify a previously published best-practice algorithm based on a literature review and our clinical experience to maintain the quality of care provided after successful type 1 laryngeal cleft repair, while reducing the total number of postoperative VFSSs by 10% or greater...
September 1, 2016: JAMA Otolaryngology—Head & Neck Surgery
https://www.readbyqxmd.com/read/27352894/collagen-content-limits-optical-coherence-tomography-image-depth-in-porcine-vocal-fold-tissue
#16
Jordan A Garcia, Fouzi Benboujja, Kathy Beaudette, Derek Rogers, Rie Maurer, Caroline Boudoux, Christopher J Hartnick
OBJECTIVE: Vocal fold scarring, a condition defined by increased collagen content, is challenging to treat without a method of noninvasively assessing vocal fold structure in vivo. The goal of this study was to observe the effects of vocal fold collagen content on optical coherence tomography imaging to develop a quantifiable marker of disease. STUDY DESIGN: Excised specimen study. SETTING: Massachusetts Eye and Ear Infirmary. SUBJECTS AND METHODS: Porcine vocal folds were injected with collagenase to remove collagen from the lamina propria...
November 2016: Otolaryngology—Head and Neck Surgery
https://www.readbyqxmd.com/read/27343208/optical-coherence-tomography-of-outer-retinal-holes-in-senile-retinoschisis-and-schisis-detachment
#17
Aleksandra V Rachitskaya, Alex Yuan, Rishi P Singh, Jonathan E Sears, Andrew P Schachat
PURPOSE: On clinical examination, it can be challenging to differentiate retinoschisis with outer retinal hole from schisis-detachment. This study examined the role of outer retinal hole spectral domain optical coherence tomography (SD-OCT) imaging in conjunction with imaging of the posterior schisis cavity edge in differentiating between these conditions. METHODS: This is a retrospective case series. Out of 500 subjects with ICD-9 diagnoses of senile retinoschisis (361...
June 24, 2016: British Journal of Ophthalmology
https://www.readbyqxmd.com/read/27322708/orbital-exenteration-the-10-year-massachusetts-eye-and-ear-infirmary-experience
#18
Sonali T Nagendran, N Grace Lee, Aaron Fay, Daniel R Lefebvre, Francis C Sutula, Suzanne K Freitag
The authors report their experience with orbital exenteration surgery at one academic institution over a 10-year period and review the literature. This retrospective cohort study monitored outcomes of all patients who underwent orbital exenteration surgery at Massachusetts Eye and Ear Infirmary between January 2003 and January 2013. Patients with no follow-up data or survival data were excluded from the study. The main outcome measures were surgical complications, disease status of surgical margins, need for adjuvant treatment, local recurrence, metastases and survival...
August 2016: Orbit
https://www.readbyqxmd.com/read/27273408/focal-endolymphatic-hydrops-as-seen-in-the-pars-inferior-of-the-human-inner-ear
#19
Joseph B Nadol
HYPOTHESIS: Endolymphatic hydrops of the human inner ear may be localized focally in the pars inferior of the human inner ear. BACKGROUND: Endolymphatic hydrops may be found in the human inner ear in patients who in life had suffered from Ménière's syndrome or a variety of other disorders. The degree of endolymphatic hydrops may differ based on location in the inner ear. METHODS: A computer-assisted search of all cases in the collection of the Massachusetts Eye and Ear Infirmary in which endolymphatic hydrops was found in the inner ear yielded 13 specimens in which there was good evidence for focal endolymphatic hydrops in the pars inferior...
August 2016: Otology & Neurotology
https://www.readbyqxmd.com/read/27273406/cochlear-histopathology-as-observed-in-two-patients-with-a-cochlear-implant-electrode-with-positioner
#20
Takefumi Kamakura, Joseph B Nadol
HYPOTHESIS: This study reports the cochlear histopathology of two patients who during life underwent cochlear implantation with a positioner. BACKGROUND: A silastic positioner introduced by the Advanced Bionics Corporation in 1999 was designed to position the electrode of the cochlear implant close to the modiolus. The positioner was recalled in the United States in July 2002 because of an apparent higher incidence of bacterial meningitis in patients in whom the positioner had been placed...
July 2016: Otology & Neurotology
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