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Prostaglandin D2

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https://www.readbyqxmd.com/read/29132038/hemodynamics-of-the-corpus-luteum-in-mares-during-experimentally-impaired-luteogenesis-and-partial-luteolysis
#1
J C Ferreira, L F Novaes Filho, Y L Boakari, H S Canesin, D L Thompson, F S Lima, C Meira
The aim of the current project was to characterize the luteal vascularity and the plasma concentrations of progesterone (P4), prolactin (PRL) and 13,14-dihydro-15-keto-PGF2α (PGFM) in mares with luteal disturbances during early and mid-diestrus. In Experiment 1, twenty-one mares were treated with 2 mL of 0.9% NaCl, or 1 mg Dinoprost, or 10 mg Dinoprost on day two after ovulation (Control-D2, 1/10PGF-D2 and PGF-D2 groups, respectively; n = 7 mares/group). In Experiment 2, similar treatments were performed eight days post-ovulation using a different cohort of 21 mares (Control-D8, 1/10PGF-D8 and PGF-D8 groups, respectively; n = 7 mares/group)...
November 4, 2017: Theriogenology
https://www.readbyqxmd.com/read/29124765/lipocalin-type-prostaglandin-d-synthase-derived-pgd2-attenuates-malignant-properties-of-endothelial-cells-in-tumor
#2
Keisuke Omori, Teppei Morikawa, Akiko Kunita, Tatsuro Nakamura, Kosuke Aritake, Yoshihiro Urade, Masashi Fukayama, Takahisa Murata
Endothelial cells (ECs) are a key component of the tumor microenvironment. They have abnormal characteristics compared to the ECs in normal tissues. Here, we found a marked increase in lipocalin-type prostaglandin D synthase (L-PGDS) mRNA (Ptgds) expression in ECs isolated from mouse melanoma. Immunostaining of mouse melanoma revealed expression of L-PGDS protein in the ECs. In situ hybridization also showed L-PGDS (PTGDS) mRNA expression in the ECs of human melanoma and oral squamous cell carcinoma. In vitro experiments showed that stimulation with tumor cell-derived IL-1 and TNF-α increased L-PGDS mRNA expression and its product prostaglandin D2 (PGD2 ) in human normal ECs...
November 10, 2017: Journal of Pathology
https://www.readbyqxmd.com/read/29123134/divergent-proliferation-patterns-of-distinct-human-hair-follicle-epithelial-progenitor-niches-in-situ-and-their-differential-responsiveness-to-prostaglandin-d2
#3
Talveen S Purba, Michael Peake, Bessam Farjo, Nilofer Farjo, Ranjit K Bhogal, Gail Jenkins, Ralf Paus
Human scalp hair follicles (hHF) harbour several epithelial stem (eHFSC) and progenitor cell sub-populations organised into spatially distinct niches. However, the constitutive cell cycle activity of these niches remains to be characterized in situ. Therefore, the current study has studied these characteristics of keratin 15+ (K15), CD200+ or CD34+ cells within anagen VI hHFs by immunohistomorphometry, using Ki-67 and 5-ethynyl-2'-deoxyuridine (EdU). We quantitatively demonstrate in situ the relative cell cycle inactivity of the CD200+/K15+ bulge compared to other non-bulge CD34+ and K15+ progenitor compartments and found that in each recognized eHFSC/progenitor niche, proliferation associates negatively with eHFSC-marker expression...
November 9, 2017: Scientific Reports
https://www.readbyqxmd.com/read/29105371/mast-cells-partially-contribute-to-mucosal-adjuvanticity-of-surfactin-in-mice
#4
Naoto Yoshino, Ryosuke Takeshita, Hanae Kawamura, Yutaka Sasaki, Masahiro Kagabu, Toru Sugiyama, Yasushi Muraki, Shigehiro Sato
INTRODUCTION: Surfactin (SF) is a cyclic lipopeptide that has potent mucosal adjuvant properties. However, immunological mechanisms of SF adjuvant action have not yet been elucidated. As some cyclic lipopeptides, such as polymyxin, can stimulate histamine release from mast cells, we hypothesized that mast cell activation is critical for SF adjuvanticity. METHODS/RESULTS: We observed that following intranasal immunization with ovalbumin (OVA) plus SF, the titers of the OVA-specific antibody (Ab) in the mucosal secretions and plasma of mast cell-deficient mice were significantly lower than those in congenic normal mice, although OVA-specific Ab did not entirely disappear from mast cell-deficient mice...
November 3, 2017: Immunity, Inflammation and Disease
https://www.readbyqxmd.com/read/29102931/corpus-luteum-regression-induced-by-prostaglandin-f2%C3%AE-in-microminipigs-during-the-normal-estrous-cycle
#5
Michiko Noguchi, Masaya Hirata, Hiroaki Kawaguchi, Akihide Tanimoto
Induction of corpus luteum regression and subsequent estrus using prostaglandin F2α (PGF2α) in microminipigs was investigated. Microminipigs with normal estrous cycle were treated with PGF2α as 0.75 mg (0.75 PG group, n=3) or 1.5 mg (1.5 PG group, n=4) dinoprost injected into the vulva at 24-h intervals at 10 days after the onset of estrus (D0), D1 and D2. Three microminipigs were not treated (control group). The estrous interval in the 1.5 PG group was significantly shortened compared to the control and 0...
November 2017: In Vivo
https://www.readbyqxmd.com/read/29061012/-investigation-on-the-role-and-mechanism-of-prostagland-in-d2-synthase-in-non-small-cell-lung-cancer
#6
L P He, Y F Chen, J Yang
Objective: To investigate prostaglandin D2 synthase (PTGDS) expression in non-small cell lung carcinoma (NSCLC) and clarify whether PTGDS could be a biomarke. Methods: Firstly, the protein expression level of PTGDS in adenocarcinoma (ADC) and squamous cell carcinoma (SCC) were analyzed respectively through Gene Expression Omnibus (GEO)dataset. Then, the results were verified by using tissue microarray (TMA). At last, in order to explore the inner mechanism, lung adenocarcinoma cell lines A549 and Calu-3 were selected to over-express PTGDS, and then transwell chamber assay and Western blotting were used to detect associated changes...
October 17, 2017: Zhonghua Yi Xue za Zhi [Chinese medical journal]
https://www.readbyqxmd.com/read/29042181/opposing-roles-of-pgd2-in-gbm
#7
Matthew Thomas Ferreira, Renata Nascimento Gomes, Alexandros Theodoros Panagopoulos, Fernando Gonçalves de Almeida, José Carlos Esteves Veiga, Alison Colquhoun
BACKGROUND: The World Health Organization classifies glioblastoma (GBM) as a grade IV astrocytoma. Despite the advances in chemotherapy, surgery, and radiation treatments that improve a patient's length of survival, the overall trajectory of the disease remains unchanged. GBM cells produce significant levels of various types of bioactive lipids. Prostaglandin D2 (PGD2) influences both pro- and anti-tumorigenic activities in the cell; however, its role in GBM is unclear. Therefore, this study aimed to identify the impact of PGD2 on GBM cell activities in vitro...
October 16, 2017: Prostaglandins & Other Lipid Mediators
https://www.readbyqxmd.com/read/29038009/advances-in-mechanisms-of-allergic-disease-in-2016
#8
Marc E Rothenberg, Hirohisa Saito, R Stokes Peebles
This review highlights advances in mechanisms of allergic disease, particularly type 2 innate lymphoid cells; TH2 lymphocytes; eicosanoid regulation of inflammation; extracellular vesicles in allergic responses; IL-33; microbiome properties, especially as they relate to mucosal barrier function; and a series of findings concerning the allergic inflammatory cells eosinophils, basophils, and mast cells. During the last year, mechanistic advances occurred in understanding type 2 innate lymphoid cells, particularly related to their response to ozone, involvement with experimental food allergy responses, and regulation by IL-33...
October 13, 2017: Journal of Allergy and Clinical Immunology
https://www.readbyqxmd.com/read/28992598/global-transcriptomic-analysis-of-zebrafish-in-response-to-embryonic-exposure-to-three-antidepressants-amitriptyline-fluoxetine-and-mianserin
#9
Minghong Wu, Shuai Liu, Lei Hu, Haidong Qu, Chenyuan Pan, Penghui Lei, Yingjia Shen, Ming Yang
Antidepressants are among the most commonly detected pharmaceuticals in aqueous systems, and, as emerging organic pollutants, may exert negative effects on non-target aquatic organisms. Previously, it has been revealed that antidepressant exposure significantly inhibits the growth and development of fish during their early developmental stages. Thus, in the present study, we aimed to identify and compare the underlying mechanisms of action of different antidepressants at the transcriptional level using zebrafish (Danio rerio) embryos...
September 28, 2017: Aquatic Toxicology
https://www.readbyqxmd.com/read/28955943/the-low-molecular-weight-fraction-of-human-serum-albumin-upregulates-cox2-prostaglandin-e2-and-prostaglandin-d2-under-inflammatory-conditions-in-osteoarthritic-knee-synovial-fibroblasts
#10
Elizabeth D Frederick, Melissa A Hausburg, Gregory W Thomas, Leonard T Rael, Edward Brody, David Bar-Or
BACKGROUND: The ability to decrease inflammation and promote healing is important in the intervention and management of a variety of disease states, including osteoarthritis of the knee (OAK). Even though cyclooxygenase 2 (COX2) has an established pro-inflammatory role, evidence suggests it is also critical to the resolution that occurs after the initial activation phase of the immune response. In this study, we investigated the effects of the low molecular weight fraction of 5% human serum albumin (LMWF-5A), an agent that has proven to decrease pain and improve function in OAK patients after intra-articular injection, on the expression of COX2 and its downstream products, prostaglandins (PGs)...
December 2016: Biochemistry and Biophysics Reports
https://www.readbyqxmd.com/read/28951192/role-of-prostaglandin-e2-in-bronchoconstriction-triggered-cough-response-in-guinea-pigs
#11
Akihito Okazaki, Johsuke Hara, Noriyuki Ohkura, Masaki Fujimura, Tamami Sakai, Miki Abo, Nobuyuki Katayama, Kazuo Kasahara, Shinji Nakao
A feature of cough variant asthma is a heightened cough response to bronchoconstriction. The mediators of this response are unknown. This study was designed to elucidate the role of lipid mediators in bronchoconstriction-triggered cough response in an experimental animal model. We examined the influence of bronchoconstriction on cell components and mediators including prostaglandin E2 (PGE2) in bronchoalveolar lavage fluid (BALF). We studied the cough response to bronchoconstriction (CRB) by measuring the correlation between the increase in enhanced pause (Penh), an index of bronchoconstriction, and cough counts induced by methacholine (Mch) inhalation in conscious guinea pigs...
September 22, 2017: Pulmonary Pharmacology & Therapeutics
https://www.readbyqxmd.com/read/28941500/prostaglandin-d2-uses-components-of-ros-signaling-to-enhance-testosterone-production-in-keratinocytes
#12
Alon Mantel, J Tyson McDonald, Kennedy Goldsborough, Valerie M Harvey, Joanne Chan
Elevated levels of prostaglandin D2 (PGD2) have been shown to be present in the bald scalp of androgenic alopecia (AGA) patients and to functionally inhibit hair growth. However, its precise mechanism in AGA has yet to be clearly defined. Although testosterone plays a critical role in the initiation and progression of AGA, the existence of a possible link between PGD2 and testosterone in skin has not been investigated. Here we show that human keratinocytes treated with PGD2 show enhanced capacity to convert the weak androgen, androstenedione, to testosterone...
October 2017: Journal of Investigative Dermatology. Symposium Proceedings
https://www.readbyqxmd.com/read/28901404/effects-of-anticholinergic-agent-on-mirna-profiles-and-transcriptomes-in-a-murine-model-of-allergic-rhinitis
#13
Minghua Hou, Wei Li, Zuozhong Xie, Jingang Ai, Bo Sun, Guolin Tan
Anticholinergic agent, ipratropium bromide (IB) ameliorates symptoms of allergic rhinitis (AR) using neuroimmunologic mechanisms. However, the underlying molecular mechanism remains largely unclear. In the present study, 27 mice with AR induced by ovalbumin were randomly allocated to one of three groups: Model group, model group with IB treatment for 2 weeks, and model group with IB treatment for 4 weeks. Allergic symptoms were evaluated according to symptoms scores. Differentially expressed genes [microRNAs (miRNAs) and messenger RNAs (mRNAs)] of nasal mucosa were identified by microarray analysis...
November 2017: Molecular Medicine Reports
https://www.readbyqxmd.com/read/28898456/urinary-prostaglandin-d2-metabolite-excretion-during-the-first-six-months-of-life-was-significantly-lower-in-breast-fed-than-formula-fed-infants
#14
Hiromichi Shoji, Naho Ikeda, Tomohiro Kitamura, Hiroki Suganuma, Mai Ohba, Toshiaki Okuno, Takehiko Yokomizo, Toshiaki Shimizu
AIM: The metabolic changes that occur during the postnatal weaning period appear to be particularly important for future health and breast milk is considered to provide the optimal source of infant nutrition. This pilot study from September 2013 to May 2015 examined the effect of breastfeeding on prostaglandin metabolism in healthy term infants. METHODS: Urine samples were collected from 19 infants at one month of age in the Juntendo University Hospital, Tokyo, Japan...
September 12, 2017: Acta Paediatrica
https://www.readbyqxmd.com/read/28878675/inhibition-of-collagen-induced-platelet-aggregation-by-the-secobutanolide-secolincomolide-a-from-lindera-obtusiloba-blume
#15
Sang-Hyuk Jung, Joo-Hui Han, Hyun-Soo Park, Jung-Jin Lee, Seo Young Yang, Young Ho Kim, Kyung-Sun Heo, Chang-Seon Myung
Atherothrombosis is one of the main underlying cause of cardiovascular diseases. In addition to treating atherothrombosis with antithrombotic agents, there is growing interest in the role of natural food products and biologically active ingredients for the prevention and treatment of cardiovascular diseases. This study aimed to investigate the effect of secolincomolide A (3) isolated from Lindera obtusiloba Blume on platelet activity and identify possible signaling pathways. In our study, the antiplatelet activities of 3 were measured by collagen-induced platelet aggregation and serotonin secretion in freshly isolated rabbit platelets...
2017: Frontiers in Pharmacology
https://www.readbyqxmd.com/read/28865408/peptide-based-vaccines-derived-from-fc%C3%AE%C2%B5ri-beta-subunit-can-reduce-allergic-response-in-mice-model
#16
Ahad Zare, Ali Akbar Pourfathollah, Zahra Pourpak, Janos Szebeni, Seyed Mohammad Reza Ghaffari, Gholam Ali Kardar
Current therapeutic approaches in allergic diseases especially asthma generally focus on using immunological strategies. According to the importance of FceRI in controlling allergic response we used two extracellular regions of Fc epsilon receptor I (FceRI) beta subunit peptides to design two peptide-based vaccines. Probably these peptides vaccines by triggering the immune response to FceRI can reduce the allergic symptoms through blocking the IgE specific receptor. Two extracellular parts of FceRI beta subunit were made by peptide synthesizer and conjugated with keyhole limpet Hemocyanin...
August 2017: Iranian Journal of Allergy, Asthma, and Immunology
https://www.readbyqxmd.com/read/28852125/irf2bp2-deficient-microglia-block-the-anxiolytic-effect-of-enhanced-postnatal-care
#17
Aswin Hari, Shelly A Cruz, Zhaohong Qin, Pascal Couture, Ragnar O Vilmundarson, Hua Huang, Alexandre F R Stewart, Hsiao-Huei Chen
Enhanced postnatal care (EPC) increases resilience to adversity in adulthood. Since microglia participate in shaping neural circuits, we asked how ablation of an inflammation-suppressing factor IRF2BP2 (Interferon Regulatory Factor 2 Binding Protein 2) in microglia would affect the responses to EPC. Mice lacking IRF2BP2 in microglia (KO) and littermate controls (WT) were subjected to EPC during the first 3 weeks after birth. EPC reduced anxiety in WT but not KO mice. This was associated with reduced inflammatory cytokine expression in the hypothalamus...
August 29, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28844566/role-of-trka-signalling-and-mast-cells-in-the-initiation-of-osteoarthritis-pain-in-the-monoiodoacetate-model
#18
J Sousa-Valente, L Calvo, V Vacca, R Simeoli, J C Arévalo, M Malcangio
OBJECTIVE: Aiming to delineate novel neuro-immune mechanisms for NGF/TrkA signalling in osteoarthritis (OA) pain, we evaluated inflammatory changes in the knee joints following injection of monoiodoacetate (MIA) in mice carrying a TrkA receptor mutation (P782S; TrkA KI mice). METHOD: In behavioural studies we monitored mechanical hypersensitivity following intra-articular MIA and oral prostaglandin D2 (PGD2) synthase inhibitor treatments. In immunohistochemical studies we quantified joint mast cell numbers, calcitonin gene-related peptide expression in synovia and dorsal root ganglia, spinal cord neuron activation and microgliosis...
August 24, 2017: Osteoarthritis and Cartilage
https://www.readbyqxmd.com/read/28842638/efficacy-of-laropiprant-in-minimizing-brain-injury-following-experimental-intracerebral-hemorrhage
#19
Abdullah Shafique Ahmad, Monique Mendes, Damian Hernandez, Sylvain Doré
Intracerebral hemorrhage (ICH) is one of the most devastating and disabling forms of stroke, yet effective treatments are still lacking. Prostaglandins and their receptors have been implicated in playing vital roles in ICH outcomes. Recently, laropiprant, a DP1 receptor antagonist, has been used in combination with niacin to abolish the prostaglandin D2-(PGD2)-induced flushing. Here, we test the hypothesis that laropiprant limits bleeding and rescues the brain from ICH. Wildtype (WT) and DP1(-/-) mice were subjected ICH and neurologic deficits and hemorrhagic lesion outcomes were evaluated at 72 hours after the ICH...
August 25, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28822852/prostaglandin-d2-is-the-major-cyclooxygenase-1-derived-product-in-prepartum-mouse-uteri-where-it-mediates-an-enhanced-in-vitro-myometrial-contraction
#20
Bin Liu, Jingli Yang, Wenhong Luo, Yingzhan Zhang, Jiarong Li, Hui Li, Lelin Chen, Yingbi Zhou
This study aimed to determine whether prostaglandin D2 (PGD2) is a major uterine cyclooxygenase (COX) product and if so, we wanted to examine the underlying mechanism, its relation to COX-1-mediated metabolism, and how it influences the in vitro myometrial contraction during the late stage of pregnancy. The production of PGD2 or responses evoked by the prostanoid were determined in uteri isolated from prepartum and/or non-pregnant C57Bl/6 wild-type (WT) or COX-1(-/-) mice. Results showed that PGD2, which was not detected in non-pregnant counterparts, appears as the major prostanoid in prepartum (<24h prior to parturition) mouse uteri...
August 16, 2017: European Journal of Pharmacology
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