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https://www.readbyqxmd.com/read/29330337/role-of-germline-aberrations-affecting-ctnna1-map3k6-and-myd88-in-gastric-cancer-susceptibility
#1
Robbert D A Weren, Rachel S van der Post, Ingrid P Vogelaar, J Han van Krieken, Liesbeth Spruijt, Jan Lubinski, Anna Jakubowska, Urszula Teodorczyk, Cora M Aalfs, Liselotte P van Hest, Carla Oliveira, Eveline J Kamping, Hans K Schackert, Guglielmina N Ranzani, Encarna B Gómez García, Frederik J Hes, Elke Holinski-Feder, Maurizio Genuardi, Margreet G E M Ausems, Rolf H Sijmons, Anja Wagner, Lizet E van der Kolk, Annemieke Cats, Inga Bjørnevoll, Nicoline Hoogerbrugge, Marjolijn J L Ligtenberg
BACKGROUND: In approximately 10% of all gastric cancer (GC) cases, a heritable cause is suspected. A subset of these cases have a causative germline CDH1 mutation; however, in most cases the cause remains unknown. Our objective was to assess to what extent these remaining cases may be explained by germline mutations in the novel candidate GC predisposing genes CTNNA1, MAP3K6 or MYD88. METHODS: We sequenced a large cohort of unexplained young and/or familial patients with GC (n=286) without a CDH1germline mutation for germline variants affecting CTNNA1, MAP3K6 and MYD88 using a targeted next-generation sequencing approach based on single-molecule molecular inversion probes...
January 12, 2018: Journal of Medical Genetics
https://www.readbyqxmd.com/read/29329524/uncovering-the-evolutionary-history-of-neo-xy-sex-chromosomes-in-the-grasshopper-ronderosia-bergii-orthoptera-melanoplinae-through-satellite-dna-analysis
#2
Octavio M Palacios-Gimenez, Diogo Milani, Bernardo Lemos, Elio R Castillo, Dardo A Martí, Erica Ramos, Cesar Martins, Diogo C Cabral-de-Mello
BACKGROUND: Neo-sex chromosome systems arose independently multiple times in evolution, presenting the remarkable characteristic of repetitive DNAs accumulation. Among grasshoppers, occurrence of neo-XY was repeatedly noticed in Melanoplinae. Here we analyzed the most abundant tandem repeats of R. bergii (2n = 22, neo-XY♂) using deep Illumina sequencing and graph-based clustering in order to address the neo-sex chromosomes evolution. RESULTS: The analyses revealed ten families of satDNAs comprising about ~1% of the male genome, which occupied mainly C-positive regions of autosomes...
January 8, 2018: BMC Evolutionary Biology
https://www.readbyqxmd.com/read/29328685/tunable-intrinsic-plasmons-due-to-band-inversion-in-topological-materials
#3
Furu Zhang, Jianhui Zhou, Di Xiao, Yugui Yao
Band inversion has led to rich physical effects in both topological insulators and topological semimetals. It has been found that the inverted band structure with the Mexican-hat dispersion could enhance the interband correlation leading to a strong intrinsic plasmon excitation. Its frequency ranges from several meV to tens of meV and can be effectively tuned by the external fields. The electron-hole asymmetric term splits the peak of the plasmon excitation into double peaks. The fate and properties of this plasmon excitation can also act as a probe to characterize the topological phases even in lightly doped systems...
December 29, 2017: Physical Review Letters
https://www.readbyqxmd.com/read/29326982/discovery-of-slow-magnetic-fluctuations-and-critical-slowing-down-in-the-pseudogap-phase-of-yba2cu3o-y
#4
Jian Zhang, Zhaofeng Ding, Cheng Tan, Kevin Huang, Oscar O Bernal, Pei-Chun Ho, Gerald D Morris, Adrian D Hillier, Pabitra K Biswas, Stephen P Cottrell, Hui Xiang, Xin Yao, Douglas E MacLaughlin, Lei Shu
The origin of the pseudogap region below a temperature T* is at the heart of the mysteries of cuprate high-temperature superconductors. Unusual properties of the pseudogap phase, such as broken time-reversal and inversion symmetry are observed in several symmetry-sensitive experiments: polarized neutron diffraction, optical birefringence, dichroic angle-resolved photoemission spectroscopy, second harmonic generation, and polar Kerr effect. These properties suggest that the pseudogap region is a genuine thermodynamic phase and are predicted by theories invoking ordered loop currents or other forms of intra-unit-cell (IUC) magnetic order...
January 2018: Science Advances
https://www.readbyqxmd.com/read/29317434/investigating-low-velocity-fluid-flow-in-tumors-using-convection-mri
#5
Simon Walker-Samuel, Thomas A Roberts, Rajiv Ramasawmy, Jake S Burrell, Sean P Johnson, Bernard M Siow, Simon Richardson, Miguel R Goncalves, Douglas Pendse, Simon P Robinson, R Barbara Pedley, Mark F Lythgoe
Several distinct fluid flow phenomena occur in solid tumors, including intravascular blood flow and interstitial convection. Interstitial fluid pressure is often raised in solid tumors, which can limit drug delivery. To probe low-velocity flow in tumors resulting from raised interstitial fluid pressure, we developed a novel magnetic resonance imaging (MRI) technique named convection-MRI, which uses a phase-contrast acquisition with a dual-inversion vascular nulling preparation to separate intra- and extra-vascular flow...
January 9, 2018: Cancer Research
https://www.readbyqxmd.com/read/29311418/spatiotemporal-matrix-image-formation-for-programmable-ultrasound-scanners
#6
Beatrice Berthon, Pierre Morichau-Beauchant, Jonathan Poree, Anikitos Garofalakis, Bertrand Tavitian, Mickael Tanter, Jean Provost
As programmable ultrasound scanners become more common in research laboratories, it is increasingly important to develop robust software-based image formation algorithms that can be obtained in a straightforward fashion for different types of probes and sequences with a small risk of error during implementation. In this work, we argue that as the computational power keeps increasing, it is becoming practical to directly implement an approximation to the matrix operator linking reflector point targets to the corresponding radiofrequency signals via thoroughly validated and widely available simulations software...
January 9, 2018: Physics in Medicine and Biology
https://www.readbyqxmd.com/read/29304224/in-vitro-differentiation-of-human-oocyte-like-cells-from-oogonial-stem-cells-single-cell-isolation-and-molecular-characterization
#7
Erica Silvestris, Paola Cafforio, Stella D'Oronzo, Claudia Felici, Franco Silvestris, Giuseppe Loverro
STUDY QUESTION: Are the large cells derived from cultured DEAD box polypeptide 4 (DDX4)-positive oogonial stem cells (OSCs), isolated from the ovarian cortex of non-menopausal and menopausal women, oocyte-like cells? SUMMARY ANSWER: Under appropriate culture conditions, DDX4-positive OSCs from non-menopausal and menopausal women differentiate into large haploid oocyte-like cells expressing the major oocyte markers growth differentiation factor 9 (GDF-9) and synaptonemal complex protein 3 (SYCP3) and then enter meiosis...
January 3, 2018: Human Reproduction
https://www.readbyqxmd.com/read/29302896/comparison-of-the-accuracy-of-noninvasive-hemoglobin-monitoring-for-preoperative-evaluation-between-adult-and-pediatric-patients-a-retrospective-study
#8
Yong-Hee Park, Seho Lim, Hyun Kang, Hwa-Yong Shin, Chong Wha Baek, Young Cheol Woo
We measured noninvasive hemoglobin (SpHb) levels during the pre-anesthesia visit in patients planning elective surgery. Differences between SpHb and laboratory-measured hemoglobin (Hblab) were compared between adult and pediatric patients. In the pre-anesthesia visiting office, we routinely monitor noninvasive Hb levels with oxygen saturation and heart rate using Masimo Radical-7® Pulse CO-Oximetry (Masimo Corp., Irvine, CA, USA). We attached the R1 20 (body weight, 10-50 kg) or R1 25 (body weight > 30 kg) probe on the index finger...
January 4, 2018: Journal of Clinical Monitoring and Computing
https://www.readbyqxmd.com/read/29289135/probing-resonant-energy-transfer-in-collisions-of-ammonia-with-rydberg-helium-atoms-by-microwave-spectroscopy
#9
V Zhelyazkova, S D Hogan
We present the results of experiments demonstrating the spectroscopic detection of Förster resonance energy transfer from NH3 in the X1A1 ground electronic state to helium atoms in 1sns 3S1 Rydberg levels, where n = 37 and n = 40. For these values of n, the 1sns 3S1 → 1snp 3PJ transitions in helium lie close to resonance with the ground-state inversion transitions in NH3 and can be tuned through resonance using electric fields of less than 10 V/cm. In the experiments, energy transfer was detected by direct state-selective electric field ionization of the 3S1 and 3PJ Rydberg levels and by monitoring the population of the 3DJ levels following pulsed microwave transfer from the 3PJ levels...
December 28, 2017: Journal of Chemical Physics
https://www.readbyqxmd.com/read/29287305/development-of-an-immunochromatographic-strip-incorporating-anti-mitragynine-monoclonal-antibody-conjugated-to-colloidal-gold-for-kratom-alkaloids-detection
#10
Supattra Limsuwanchote, Waraporn Putalun, Hiroyuki Tanaka, Satoshi Morimoto, Niwat Keawpradub, Juraithip Wungsintaweekul
A lateral flow-based immunochromatographic strip was developed for the rapid detection of mitragynine (MG), a dominant alkaloid found in the leaves of kratom. Monoclonal antibody (mAb) against MG (anti-MG mAb) was conjugated to colloidal gold and used as a recognition probe. MG-ovalbumin conjugate (MG-OVA) and goat anti-mouse IgG were immobilized on the strip to produce a test zone and control zone, respectively. Based on the principle of a competitive assay, MG in a test sample competed with MG-OVA resident in the test zone to bind with colloidal gold-anti-MG mAb, resulting in an inverse relation of color intensity at the test zone and MG amount...
December 29, 2017: Drug Testing and Analysis
https://www.readbyqxmd.com/read/29286288/frequency-domain-modelling-of-gain-in-pump-probe-experiment-by-an-inhomogeneous-medium
#11
Minkyung Kim, Sang Soon Oh, Ortwin Hess, Junsuk Rho
Introduction of a gain medium in lossy plasmonic metamaterials reduces and compensates losses or even amplifies an incident light often with nonlinear optical effect. Here, optical gain in a pump-probe experimental setup is effectively calculated in the frequency-domain by approximating a gain material as an inhomogeneous medium. Spatially varying local field amplitudes of the pump and probe beams are included in the model to reproduce the inhomogeneous gain effect, in which population inversion occurs most strongly near the surface and decays along the propagation direction...
December 29, 2017: Journal of Physics. Condensed Matter: An Institute of Physics Journal
https://www.readbyqxmd.com/read/29283349/calculation-of-volumetric-sound-field-of-pulsed-air-coupled-ultrasound-transducers-based-on-single-plane-measurements
#12
Sergio J Sanabria, Torben Marhenke, Roman Furrer, Jurg Neuenschwander
Quantitative and reproducible air-coupled ultrasound (ACU) testing requires characterization of the volumetric pressure fields radiated by ACU probes. In this paper, a closed-form reradiation method combining the Rayleigh-Sommerfeld integral and time-reversal acoustics is proposed, which allows calculation of both near- field and far-field based on a single-plane measurement. The method was validated for both 3-D (circular, square) and 2-D (rectangular) planar transducers in the 50-230 kHz range. The pressure fields were scanned with a calibrated microphone...
January 2018: IEEE Transactions on Ultrasonics, Ferroelectrics, and Frequency Control
https://www.readbyqxmd.com/read/29278436/probing-the-surfaces-of-core-shell-and-hollow-nanoparticles-by-solvent-relaxation-nmr
#13
M R Hossain, D Wray, A Paul, P C Griffiths
Measurement of the spin-spin NMR relaxation time (or its inverse, the rate) of water molecules in aqueous nanoparticle dispersions has become a popular approach to probe of the nature and structure of the particle surface and any adsorbed species. Here, we report on the characterisation of aqueous dispersions of hollow amorphous nanoparticles, that have two liquid accessible surfaces (inner cavity surface and outer shell surface), plus the solid (silica) and core-shell (titania-silica) nanoparticle precursors from which the hollow particles have been prepared...
December 26, 2017: Magnetic Resonance in Chemistry: MRC
https://www.readbyqxmd.com/read/29278023/effect-of-%C3%AE-tocopherol-megadoses-on-hematologic-parameters-and-antioxidant-capacity-of-rats-in-an-ultraendurance-probe
#14
V J Clemente-Suárez, J Mielgo-Ayuso, J L Quiles, A Varela-Lopez, P Aranda
This study was aimed to analyze the effect of two different megadoses of α-tocopherol (vit E) in the antioxidant activity and red and white blood series of Wistar rats after a 180-min ultraendurance probe. Three groups of 10 rats were analyzed; VEAG: acute administration of a megadoses of 5,000 IU/kg of vit E the day before the probe; VECG: chronic administration of 1,000 IU/kg/day of vit E for 6 days before the probe; CG: placebo administration. VEAG presented white cells, red blood cells, hematocrit, hemoglobin values significantly higher than CG and VECG (p < 0...
December 1, 2017: Physiology International
https://www.readbyqxmd.com/read/29262418/gastro-oesophageal-reflux-and-apnoea-is-there-a-temporal-relationship
#15
Thomas Rossor, Gwendolyn Andradi, Kamal Ali, Ravindra Bhat, Anne Greenough
BACKGROUND: Gastro-oesophageal reflux (GOR) and apnoea are common in infants; whether there is a causal relationship is controversial. OBJECTIVES: To determine whether there was a temporal relationship between GOR and apnoea, in particular, the frequency of obstructive apnoeas and if the frequency of GOR episodes correlated with apnoea frequency when maturity at testing was taken into account. METHODS: Polysomnography and pH/multichannel intraluminal impedance (MII) studies were performed...
December 21, 2017: Neonatology
https://www.readbyqxmd.com/read/29251669/non-invasive-assessment-of-intra-abdominal-pressure-using-ultrasound-guided-tonometry-a-proof-of-concept-study
#16
Andreas Bloch, Michael Glas, Andreas Kohler, Ulrich Baumann, Stephan M Jakob
BACKGROUND: Intra-abdominal hypertension jeopardizes abdominal organ perfusion and venous return. Contemporary recognition of elevated intra-abdominal pressure (IAP) plays a crucial role in reducing mortality and morbidity. We evaluated ultrasound guided tonometry in this context hypothesizing that the vertical chamber diameter of this device inversely correlates with intra-abdominal pressure. METHODS: IAP was increased in six 5 mmHg steps to 40 mmHg by instillation of normal saline into the peritoneal cavity of eight anesthetized pigs...
December 14, 2017: Shock
https://www.readbyqxmd.com/read/29250902/biochemical-characterization-and-mechanistic-analysis-of-the-levoglucosan-kinase-from-lipomyces-starkeyi
#17
Christina Rother, Alexander Gutmann, Ramakrishna Gudiminchi, Hansjörg Weber, Alexander Lepak, Bernd Nidetzky
Levoglucosan kinase (LGK) catalyzes the simultaneous hydrolysis and phosphorylation of levoglucosan (1,6-anhydro-β-D-glucopyranose) in the presence of Mg2+-ATP. For the Lipomyces starkeyi LGK, we show here with real-time in situ NMR spectroscopy at 10°C and pH 7.0 that the enzymatic reaction proceeds with inversion of anomeric stereochemistry, resulting in the formation of α-D-glucose-6-phosphate, in a manner reminiscent of an inverting β-glycoside hydrolase. Kinetic characterization revealed the Mg2+ concentration for optimum activity (20-50 mM), the apparent binding of levoglucosan (Km = 180 mM) and ATP (Km = 1...
December 18, 2017: Chembiochem: a European Journal of Chemical Biology
https://www.readbyqxmd.com/read/29240995/mono-chromophoric-design-strategy-for-tetrazine-based-colorful-bioorthogonal-probes-with-a-single-fluorescent-core-skeleton
#18
Youngjun Lee, Wansang Cho, June Sung, Eunha Kim, Seung Bum Park
Fluorogenic bioorthogonal probe is ideal for fluorescent imaging in live cell condition. By taking advantage of dual functionality of tetrazine (Tz), bioorthogonal reaction unit as well as fluorescence quencher, fluorophore-Tz conjugate (FLTz) has been utilized for fluorescent live cell imaging via inverse electron-demand Diels-Alder (iEDDA) type bioorthogonal reaction. However, most of FLTz strategies rely on donor-acceptor type energy transfer mechanism which limits red-shifting of probes' emission wavelength without deterioration of fluorescent turn-on/off ratio...
December 14, 2017: Journal of the American Chemical Society
https://www.readbyqxmd.com/read/29232014/mutations-of-the-glycine-cleavage-system-genes-possibly-affect-the-negative-symptoms-of-schizophrenia-through-metabolomic-profile-changes
#19
Akane Yoshikawa, Fumichika Nishimura, Aya Inai, Yosuke Eriguchi, Masaki Nishioka, Atsuhiko Takaya, Mamoru Tochigi, Yoshiya Kawamura, Tadashi Umekage, Kayoko Kato, Tsukasa Sasaki, Yoshiaki Ohashi, Kazuya Iwamoto, Kiyoto Kasai, Chihiro Kakiuchi
AIM: Hypofunction of N-methyl-D-aspartate receptors (NMDARs) may contribute to the pathophysiology of schizophrenia (SCZ). Recently, the glycine cleavage system (GCS) was shown to affect NMDAR function in the brain. GCS functional defects cause nonketotic hyperglycinemia (NKH), the atypical phenotype of which presents psychiatric symptoms similar to SCZ. Here, we examined the involvement of GCS in SCZ. METHODS: First, to identify the rare variants and the exonic deletions, we re-sequenced all the coding exons and the splice sites of four GCS genes (GLDC, AMT, GCSH, DLD) in 474 patients with SCZ and 475 controls and performed multiplex ligation-dependent probe amplification (MLPA) analysis in SCZ...
December 12, 2017: Psychiatry and Clinical Neurosciences
https://www.readbyqxmd.com/read/29219497/binding-energy-of-79-cu-probing-the-structure-of-the-doubly-magic-78-ni-from-only-one-proton-away
#20
A Welker, N A S Althubiti, D Atanasov, K Blaum, T E Cocolios, F Herfurth, S Kreim, D Lunney, V Manea, M Mougeot, D Neidherr, F Nowacki, A Poves, M Rosenbusch, L Schweikhard, F Wienholtz, R N Wolf, K Zuber
The masses of the neutron-rich copper isotopes ^{75-79}Cu are determined using the precision mass spectrometer ISOLTRAP at the CERN-ISOLDE facility. The trend from the new data differs significantly from that of previous results, offering a first accurate view of the mass surface adjacent to the Z=28, N=50 nuclide ^{78}Ni and supporting a doubly magic character. The new masses compare very well with large-scale shell-model calculations that predict shape coexistence in a doubly magic ^{78}Ni and a new island of inversion for Z<28...
November 10, 2017: Physical Review Letters
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