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https://www.readbyqxmd.com/read/29114430/clinical-and-radiographic-features-of-parry-romberg-syndrome
#1
Mithula Nair, Vidya Ajila, Shruthi Hegde, G Subhas Babu, Rumela Ghosh
Parry-Romberg syndrome or progressive hemifacial atrophy is a craniofacial disorder characterized by slow and progressive atrophy, generally unilateral, of facial tissues including muscles, bones and skin. The coup de sabre is a clear line of demarcation seen between the normal and abnormal structures. The severity of the facial deformity is dependent on the age of onset of the disease. Cosmetic management is the only available treatment and has to be delayed until facial growth is completed. The present case report deals with a 43-year-old woman with progressive hemifacial atrophy which started from the age of 10 months...
2017: J Istanb Univ Fac Dent
https://www.readbyqxmd.com/read/29102821/direct-enhancement-of-nitrogen-15-targets-at-high-field-by-fast-adapt-sabre
#2
Soumya S Roy, Gabriele Stevanato, Peter J Rayner, Simon B Duckett
Signal Amplification by Reversible Exchange (SABRE) is an attractive nuclear spin hyperpolarization technique capable of huge sensitivity enhancement in nuclear magnetic resonance (NMR) detection. The resonance condition of SABRE hyperpolarization depends on coherent spin mixing, which can be achieved naturally at a low magnetic field. The optimum transfer field to spin-1/2 heteronuclei is technically demanding, as it requires field strengths weaker than the earth's magnetic field for efficient spin mixing...
October 21, 2017: Journal of Magnetic Resonance
https://www.readbyqxmd.com/read/29102278/incidence-of-high-risk-radiologic-features-in-patients-without-local-recurrence-after-stereotactic-ablative-radiation-therapy-for-early-stage-non-small-cell-lung-cancer
#3
M I Ronden, J R van Sörnsen de Koste, C Johnson, B J Slotman, F O B Spoelstra, C J A Haasbeek, G Blom, E M Bongers, A Warner, A Ward, D Palma, S Senan
PURPOSE: To investigate, in the setting of stereotactic ablative radiation therapy (SABR) for early-stage non-small cell lung cancer, the incidence and patterns of change in high-risk radiologic features (HRFs) in patients known to have no local recurrence. METHODS AND MATERIALS: Computed tomography (CT) scans of patients treated using volumetric modulated arc therapy SABR between 2008 and 2013 were eligible if follow-up scans were available for 2 years and no local recurrences were diagnosed...
September 22, 2017: International Journal of Radiation Oncology, Biology, Physics
https://www.readbyqxmd.com/read/29100293/gamma-analysis-with-a-gamma-criterion-of-2-1-mm-for-stereotactic-ablative-radiotherapy-delivered-with-volumetric-modulated-arc-therapy-technique-a-single-institution-experience
#4
Jung-In Kim, Minsoo Chun, Hong-Gyun Wu, Eui Kyu Chie, Hak Jae Kim, Jin Ho Kim, Jong Min Park
To report a single-institution experience of gamma evaluations with 2%/1 mm for stereotactic ablative radiotherapy (SABR) delivered with volumetric modulated arc therapy (VMAT) technique, from January 2014 to January 2016. A total of 168 SABR VMAT plans were analyzed with a gamma criterion of 2%/1 mm, a threshold value of 10%, and a tolerance level of 90%. Of the 168 cases, four cases failed with 2%/1 mm. The average passing rate was 97.0% ± 2.5%. Three of the four failed cases showed passing rates higher than 90%, which was achieved by shifting the measuring device by 1 mm in the left-to-right or anterior-to-posterior directions...
September 29, 2017: Oncotarget
https://www.readbyqxmd.com/read/29099600/electronic-structure-calculations-and-the-ising-hamiltonian
#5
Rongxin Xia, Teng Bian, Sabre Kais
Obtaining exact solutions to the Schrodinger equation for atoms, molecules and extended systems continues to be a "Holy Grail" problem which the fields of theoretical chemistry and physics have been striving to solve since inception. Recent breakthroughs have been made in the development of hardware-efficient quantum optimizers and coherent Ising machines capable of simulating hundreds of interacting spins with an Ising type Hamiltonian. One of the most vital questions pertaining to these new devices is: "Can these machines be used to perform electronic structure calculations?" Within this work we review the general procedure used by these devices and prove that there is an exact mapping between the electronic structure Hamiltonian and the Ising Hamiltonian...
November 3, 2017: Journal of Physical Chemistry. B
https://www.readbyqxmd.com/read/29090197/surgical-management-of-localized-scleroderma
#6
Jae Hyun Lee, Soo Yeon Lim, Jang Hyun Lee, Hee Chang Ahn
BACKGROUND: Localized scleroderma is characterized by a thickening of the skin from excessive collagen deposits. It is not a fatal disease, but quality of life can be adversely affected due to changes in skin appearance, joint contractures, and, rarely, serious deformities of the face and extremities. We present six cases of localized scleroderma in face from our surgical practice. METHODS: We reviewed six localized scleroderma cases that were initially treated with medication and then received follow-up surgery between April 2003 and February 2015...
September 2017: Arch Craniofac Surg
https://www.readbyqxmd.com/read/29069831/stereotactic-ablative-body-radiotherapy-for-spinal-metastasis-from-hepatocellular-carcinoma-its-oncologic-outcomes-and-risk-of-vertebral-compression-fracture
#7
Gyu Sang Yoo, Hee Chul Park, Jeong Il Yu, Do Hoon Lim, Won Kyung Cho, Eonju Lee, Sang Hoon Jung, Youngyih Han, Eun-Sang Kim, Sun-Ho Lee, Whan Eoh, Se-Jun Park, Sung-Soo Chung, Chong-Suh Lee, Joon Hyuk Lee
Spinal metastases from hepatocellular carcinoma (HCC) require high-dose irradiation for durable pain and tumor control. Stereotactic ablative body radiotherapy (SABR) enables the delivery of high-dose radiation. However, but vertebral compression fracture (VCF) can be problematic. The aim of his study is to evaluate the outcome and risk of VCF after SABR for spinal metastasis from HCC. We retrospectively reviewed 33 lesions in 42 spinal segments from 29 patients who received SABR with 1 fraction (16-20 Gy), or 3 fractions (18-45 Gy) from September 2009 to January 2015...
September 22, 2017: Oncotarget
https://www.readbyqxmd.com/read/29066125/pelvic-re-irradiation-using-stereotactic-ablative-radiotherapy-sabr-a-systematic-review
#8
REVIEW
Louise Janet Murray, John Lilley, Maria A Hawkins, Ann M Henry, Peter Dickinson, David Sebag-Montefiore
BACKGROUND AND PURPOSE: To perform a systematic review regarding the use of stereotactic ablative radiotherapy (SABR) for the re-irradiation of recurrent malignant disease within the pelvis, to guide the clinical implementation of this technique. MATERIAL AND METHODS: A systematic search strategy was adopted using the MEDLINE, EMBASE and Cochrane Library databases. RESULTS: 195 articles were identified, of which 17 were appropriate for inclusion...
October 21, 2017: Radiotherapy and Oncology: Journal of the European Society for Therapeutic Radiology and Oncology
https://www.readbyqxmd.com/read/29044168/squid-based-detection-of-ultra-low-field-multinuclear-nmr-of-substances-hyperpolarized-using-signal-amplification-by-reversible-exchange
#9
K Buckenmaier, M Rudolph, C Back, T Misztal, U Bommerich, P Fehling, D Koelle, R Kleiner, H A Mayer, K Scheffler, J Bernarding, M Plaumann
Ultra-low-field (ULF) nuclear magnetic resonance (NMR) is a promising spectroscopy method allowing for, e.g., the simultaneous detection of multiple nuclei. To overcome the low signal-to-noise ratio that usually hampers a wider application, we present here an alternative approach to ULF NMR, which makes use of the hyperpolarizing technique signal amplification by reversible exchange (SABRE). In contrast to standard parahydrogen hyperpolarization, SABRE can continuously hyperpolarize 1 H as well as other MR-active nuclei...
October 18, 2017: Scientific Reports
https://www.readbyqxmd.com/read/29037776/a-multicentre-end-to-end-dosimetry-audit-of-motion-management-4dct-defined-motion-envelope-in-radiotherapy
#10
Antony L Palmer, David Nash, John R Kearton, Shakardokht M Jafari, Sarah Muscat
PURPOSE: External dosimetry audit is valuable for the assurance of radiotherapy quality. However, motion management has not been rigorously audited, despite its complexity and importance for accuracy. We describe the first end-to-end dosimetry audit for non-SABR (stereotactic ablative body radiotherapy) lung treatments, measuring dose accumulation in a moving target, and assessing adequacy of target dose coverage. MATERIALS AND METHODS: A respiratory motion lung-phantom with custom-designed insert was used...
October 13, 2017: Radiotherapy and Oncology: Journal of the European Society for Therapeutic Radiology and Oncology
https://www.readbyqxmd.com/read/29036157/nonlinear-spline-wavefront-reconstruction-from-shack-hartmann-intensity-measurements-through-small-aberration-approximations
#11
Elisabeth Brunner, Cornelis C de Visser, Michel Verhaegen
We propose an extension of the Spline based ABerration Reconstruction (SABRE) method to Shack-Hartmann (SH) intensity measurements, through small aberration approximations of the focal spot models. The original SABRE for SH slope measurements is restricted to the use of linear spline polynomials, due to the limited amount of data, and the resolution of its reconstruction is determined by the number of lenslets. In this work, a fast algorithm is presented that directly processes the pixel information of the focal spots, allowing the employment of nonlinear polynomials for high accuracy reconstruction...
September 1, 2017: Journal of the Optical Society of America. A, Optics, Image Science, and Vision
https://www.readbyqxmd.com/read/29033164/uk-consensus-on-normal-tissue-dose-constraints-for-stereotactic-radiotherapy
#12
G G Hanna, L Murray, R Patel, S Jain, K L Aitken, K N Franks, N van As, A Tree, P Hatfield, S Harrow, F McDonald, M Ahmed, F H Saran, G J Webster, V Khoo, D Landau, D J Eaton, M A Hawkins
Six UK studies investigating stereotactic ablative radiotherapy (SABR) are currently open. Many of these involve the treatment of oligometastatic disease at different locations in the body. Members of all the trial management groups collaborated to generate a consensus document on appropriate organ at risk dose constraints. Values from existing but older reviews were updated using data from current studies. It is hoped that this unified approach will facilitate standardised implementation of SABR across the UK and will allow meaningful toxicity comparisons between SABR studies and internationally...
October 12, 2017: Clinical Oncology: a Journal of the Royal College of Radiologists
https://www.readbyqxmd.com/read/28994422/lung-cancer-sabr-effective-against-oligometastatic-disease
#13
Peter Sidaway
No abstract text is available yet for this article.
December 2017: Nature Reviews. Clinical Oncology
https://www.readbyqxmd.com/read/28990279/achieving-high-1h-nuclear-hyperpolarization-levels-with-long-lifetimes-in-a-range-of-tuberculosis-drug-scaffolds
#14
Simon Duckett, Philip Norcott, Peter J Rayner, Gary G R Green
Despite the successful use of isoniazid, rifampicin, pyrazinamide and ethambutol in the treatment of tuberculosis (TB) it is a disease of growing global concern. We illustrate here a series of methods that will dramatically improve the magnetic resonance imaging (MRI) detectability of nineteen TB relevant agents and note that the future probing of their uptake and distribution in vivo would be expected to significantly enhance their efficacy in disease treatment. This improvement in detectability is achieved by use of the parahydrogen based SABRE protocol in conjunction with the ²H-labelling of key sites within their molecular structures, and the ²H-labelling of the magnetization transfer catalyst...
October 9, 2017: Chemistry: a European Journal
https://www.readbyqxmd.com/read/28975081/radiotherapy-for-oligometastatic-lung-cancer
#15
REVIEW
Derek P Bergsma, Joseph K Salama, Deepinder P Singh, Steven J Chmura, Michael T Milano
Non-small cell lung cancer (NSCLC) typically presents at an advanced stage, which is often felt to be incurable, and such patients are usually treated with a palliative approach. Accumulating retrospective and prospective clinical evidence, including a recently completed randomized trial, support the existence of an oligometastatic disease state wherein select individuals with advanced NSCLC may experience historically unprecedented prolonged survival with aggressive local treatments, consisting of radiotherapy and/or surgery, to limited sites of metastatic disease...
2017: Frontiers in Oncology
https://www.readbyqxmd.com/read/28973074/consolidative-radiotherapy-for-limited-metastatic-non-small-cell-lung-cancer-a-phase-2-randomized-clinical-trial
#16
Puneeth Iyengar, Zabi Wardak, David E Gerber, Vasu Tumati, Chul Ahn, Randall S Hughes, Jonathan E Dowell, Naga Cheedella, Lucien Nedzi, Kenneth D Westover, Suprabha Pulipparacharuvil, Hak Choy, Robert D Timmerman
Importance: Patterns-of-failure studies suggest that in metastatic non-small-cell lung cancer (NSCLC) sites of gross disease at presentation are the first to progress when treated with chemotherapy. This knowledge has led to increased adoption of local ablative radiation therapy in patients with stage IV NSCLC, though prospective randomized evidence is limited. Objective: To determine if intervening with noninvasive stereotactic ablative radiotherapy (SAbR) prior to maintenance chemotherapy in patients with non-progressive limited metastatic NSCLC after induction therapy led to significant improvements in progression-free survival (PFS)...
September 24, 2017: JAMA Oncology
https://www.readbyqxmd.com/read/28972836/sabr-rattling-with-radiation-and-surgery-paving-a-path-toward-refined-treatment-of-early-stage-non-small-cell-lung-cancer
#17
Vasu Tumati, Puneeth Iyengar
No abstract text is available yet for this article.
February 2017: Journal of Oncology Practice
https://www.readbyqxmd.com/read/28964764/the-sabre-trial-sirolimus-angioplasty-balloon-for%C3%A2-coronary-in-stent-restenosis-angiographic-results-and-1-year-clinical-outcomes
#18
Stefan Verheye, Mathias Vrolix, Indulis Kumsars, Andrejs Erglis, Dace Sondore, Pierfrancesco Agostoni, Kristoff Cornelis, Luc Janssens, Michael Maeng, Ton Slagboom, Giovanni Amoroso, Lisette Okkels Jensen, Juan F Granada, Pieter Stella
OBJECTIVES: The aim of this first-in-human study was to assess the safety and effectiveness of the Virtue sirolimus-eluting balloon in a cohort of patients with in-stent restenosis (ISR). BACKGROUND: Angioplasty balloons coated with the cytotoxic drug paclitaxel have been widely used for ISR treatment. The Virtue angioplasty balloon (Caliber Therapeutics, New Hope, Pennsylvania) delivers sirolimus in a nanoencapsulated liquid formulation. This clinical trial is the first to examine a sirolimus-eluting balloon for ISR...
September 19, 2017: JACC. Cardiovascular Interventions
https://www.readbyqxmd.com/read/28932579/patient-reported-outcomes-following-video-assisted-thoracoscopic-vats-resection-or-stereotactic-ablative-body-radiotherapy-sabr-for-treatment-of-non-small-cell-lung-cancer-protocol-for-an-observational-pilot-study-lilac
#19
Cecilia Pompili, Kevin N Franks, Alessandro Brunelli, Yusuf S Hussain, Patricia Holch, Matthew E Callister, Jonathan M Robson, Kostas Papagiannopoulos, Galina Velikova
BACKGROUND: Lung cancer is increasingly a disease of the elderly and frail population with a median age of 70 years at diagnosis. Therefore, consideration of the impact of interventions on health-related quality of life (HRQOL) and not only absolute survival is especially important. For non-small cell lung cancer (NSCLC), video-assisted thoracoscopic surgery (VATS) has been gaining popularity over the last few decades, replacing traditional open lobectomies. For high-risk patients who are not deemed suitable for surgery, stereotactic ablative body radiotherapy (SABR) provides a potentially curative alternative...
August 2017: Journal of Thoracic Disease
https://www.readbyqxmd.com/read/28917254/stereotactic-radiotherapy-in-oligometastatic-cancer
#20
Thomas A C Kennedy, Mark T Corkum, Alexander V Louie
Oligometastatic cancer describes a disease state somewhere between localized and metastatic cancer. Proposed definitions of oligometastatic disease have typically used a cut-off of five or fewer sites of disease. Treatment of oligometastatic disease should have the goal of long-term local control, and in selected cases, disease remission. While several retrospective cohorts argue for surgical excision of limited metastases (metastasectomy) as the preferred treatment option for several clinical indications, limited randomized data exists for treating oligometastases...
September 2017: Chinese Clinical Oncology
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