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Eunji Kim, Hong-Gyun Wu, Jong Min Park, Jung-In Kim, Hak Jae Kim, Hyun-Cheol Kang
[This corrects the article DOI: 10.1371/journal.pone.0195196.].
2018: PloS One
Tosol Yu, Chan Woo Wee, Noorie Choi, Hong-Gyun Wu, Hyun-Cheol Kang, Jong Min Park, Jung-In Kim, Jin Ho Kim, Tack-Kyun Kwon, Eun-Jae Chung
OBJECTIVE: Avoidance of organs at risk has become possible with advances in image-guided volumetric-modulated arc therapy (VMAT) techniques. This study was designed to evaluate the safety and feasibility of stereotactic ablative radiotherapy (SABR) for early stage glottic cancer. This report presents the preliminary result of the first and second dose level. METHODS: Fraction size was increased from 3.5 gray (Gy) (total dose 59.5 Gy) to 9 Gy (total dose 45 Gy). Dose-limiting toxicities were defined as grade 3 or higher treatment-related toxicities...
May 14, 2018: Laryngoscope
Mohammed Yousef Aldossary, Antonio Privitera, Obai Elzamzami, Nemat Alturki, Khalid Sabr
BACKGROUND Intestinal hypoganglionosis is very rare and accounts for 3% to 5% of all classified congenital intestinal innervation disorders. Isolated hypoganglionosis of the colon is a particularly rare form of the disease, and differential diagnosis includes association with Hirschsprung's disease and chronic intestinal pseudo-obstruction (CIPO) related to visceral myopathies. Most cases are diagnosed at an early age or in childhood with only a few cases reported in adults. CASE REPORT We report a case of isolated hypoganglionosis of the rectum and sigmoid presenting as an emergency with acute intestinal obstruction in a 20-year-old male patient...
May 14, 2018: American Journal of Case Reports
Roman Ganzer, Vinodh Kumar Adithyaa Arthanareeswaran, Hashim U Ahmed, Andrea Cestari, Pascal Rischmann, Georg Salomon, Dogu Teber, Evangelos Liatsikos, Jens-Uwe Stolzenburg, Eric Barret
BACKGROUND: With growing interest in focal therapy (FT) of prostate cancer (PCa) there is an increasing armamentarium of treatment modalities including high-intensity focused ultrasound (HIFU), cryotherapy, focal laser ablation (FLA), irreversible electroporation (IRE), vascular targeted photodynamic therapy (VTP), focal brachytherapy (FBT) and stereotactic ablative radiotherapy (SABR). Currently there are no clear recommendations as to which of these technologies are appropriate for individual patient characteristics...
May 9, 2018: Prostate Cancer and Prostatic Diseases
Rosario Mazzola, Umberto Tebano, Dario Aiello, Gioacchino Di Paola, Niccolò Giaj-Levra, Francesco Ricchetti, Sergio Fersino, Alba Fiorentino, Ruggero Ruggieri, Filippo Alongi
Aim Metastases from colorectal cancer are poorly responsive to stereotactic ablative radiation therapy (SABR) due to intratumoral hypoxia. Intratumoral oxygenation is improved by administration of angiogenesis inhibitors. Thus, there could be a clinical synergistic effect of SABR with bevacizumab on metastases from colorectal cancer. The aim of this study was to evaluate the feasibility and efficacy of SABR after bevacizumab in lung oligometastases from colon cancer. Methods The data of patients with lung metastases from colon cancer who underwent SABR were retrospectively evaluated according to the following inclusion criteria: number of metastases ≤3; lung oligometastases from colon cancer in patients who underwent SABR; patients receiving previous chemotherapy alone or in combination with bevacizumab; Karnofsky performance status >80; life expectancy >6 months; at least 6 months' follow-up after SABR; presence of KRAS mutation...
December 1, 2017: Tumori
Carmen B Young, Shiliang Liu, Giulia M Muraca, Yasser Sabr, Tracy Pressey, Robert M Liston, K S Joseph
BACKGROUND: The mode of delivery for women with a previous cesarean delivery remains contentious. We conducted a study comparing maternal and infant outcomes after attempted vaginal birth after cesarean delivery versus elective repeat cesarean delivery. METHODS: We used data from the Discharge Abstract Database that includes all hospital deliveries in Canada (excluding Quebec). In our analysis, we included singleton deliveries to women between 37 and 43 weeks gestation who had a single prior cesarean delivery between April 2003 and March 2015...
May 7, 2018: CMAJ: Canadian Medical Association Journal, Journal de L'Association Medicale Canadienne
Eun Kyung Paik, Mi-Sook Kim, Young-Seok Seo, Won Jang, Jin-Kyu Kang, Chul-Koo Cho, Hyung Jun Yoo
Background: There is growing interest in the use of stereotactic ablative radiotherapy (SABR) for oligometastases. However, extreme caution should be exercised in treating tumors closely located to organs at risk (OARs) with SABR. To reduce complications, we have applied split-course SABR to oligometastases closely located to OARs or to those being retreated with radiotherapy. Methods: We retrospectively reviewed the records of patients with oligometastases who were treated with planned split-course SABR between January 2012 and December 2016...
May 2, 2018: Japanese Journal of Clinical Oncology
VÍctor Hugo Delgado-Blas, Óscar DÍaz-dÍaz, JosÉ M ViÉitez
Re-assessment of spionid specimens from Iberian Peninsula initially assigned to Dispio uncinata Hartman, 1951 and Streblospio benedicti Webster, 1879 led to the recognition of two new species from the spionid genera Dispio and Streblospio from coasts around the Iberian Peninsula. Dispio elegans sp. nov. is characterised by having an oblanceolate-shaped prostomium. In addition, the first two notopodial postchaetal lamellae are serrated with digitiform papillae, the anterior neuropodial lamellae are smooth; all branchiae are almost completely fused to the notopodial lamellae, but with the tips free; the notochaetae on chaetiger 1 are smooth, alimbate capillaries; the ventral chaetae located in the position of the sabre chaetae on chaetigers 1-2 are smooth, alimbate capillaries, but becoming granulated on chaetiger 3; and the middle and posterior chaetigers are granulated and reticulated...
April 18, 2018: Zootaxa
John Conibear, Brendan Chia, Yenting Ngai, Andrew Tom Bates, Nicholas Counsell, Rushil Patel, David Eaton, Corinne Faivre-Finn, John Fenwick, Martin Forster, Gerard G Hanna, Susan Harden, Philip Mayles, Syed Moinuddin, David Landau
INTRODUCTION: Following growing evidence to support the safety, local control (LC) and potential improvement in overall survival (OS) in patients with oligometastatic non-small cell lung cancer (NSCLC) that have been treated with local ablative therapy such as stereotactic ablative radiotherapy (SABR) and stereotactic radiosurgery (SRS), we initiate the SARON trial to investigate the impact and feasibility of adding SABR/SRS and radical radiotherapy (RRT) following standard chemotherapy on OS...
April 17, 2018: BMJ Open
Jérôme Doyen, Michel Poudenx, Jocelyn Gal, Josiane Otto, Caroline Guerder, Arash O Naghavi, Anais Gérard, Axel Leysalle, Charlotte Cohen, Bernard Padovani, Antoine Ianessi, Renaud Schiappa, Emmanuel Chamorey, Pierre-Yves Bondiau
BACKGROUND AND PURPOSE: Platinum based chemoradiotherapy is the standard of care for inoperable non-small cell lung cancer (NSCLC). With evidence that NSCLC can have a dose dependent response with stereotactic ablative radiotherapy (SABR), we hypothesize that a SABR boost on residual tumor treated with chemoradiotherapy could increase treatment efficacy. The purpose of this study was to determine feasibility of such an approach. MATERIAL AND METHODS: A prospective phase I trial was performed including 26 patients...
April 9, 2018: Radiotherapy and Oncology: Journal of the European Society for Therapeutic Radiology and Oncology
Sören Lehmkuhl, Martin Wiese, Lukas Schubert, Mathias Held, Markus Küppers, Matthias Wessling, Bernhard Blümich
Hyperpolarization methods entail a high potential to boost the sensitivity of NMR. Even though the "Signal Amplification by Reversible Exchange" (SABRE) approach uses para-enriched hydrogen, p-H2 , to repeatedly achieve high polarization levels on target molecules without altering their chemical structure, such studies are often limited to batch experiments in NMR tubes. Alternatively, this work introduces a continuous flow setup including a membrane reactor for the p-H2 , supply and consecutive detection in a 1 T NMR spectrometer...
March 31, 2018: Journal of Magnetic Resonance
Sateesh Maddirevula, Saud Alsahli, Lamees Alhabeeb, Nisha Patel, Fatema Alzahrani, Hanan E Shamseldin, Shams Anazi, Nour Ewida, Hessa S Alsaif, Jawahir Y Mohamed, Anas M Alazami, Niema Ibrahim, Firdous Abdulwahab, Mais Hashem, Mohamed Abouelhoda, Dorota Monies, Nada Al Tassan, Muneera Alshammari, Afaf Alsagheir, Mohammed Zain Seidahmed, Samira Sogati, Mona S Aglan, Muddathir H Hamad, Mustafa A Salih, Ahlam A Hamed, Nadia Alhashmi, Amira Nabil, Fatima Alfadli, Ghada M H Abdel-Salam, Hisham Alkuraya, Winnie Ong Peitee, W T Keng, Abdullah Qasem, Aziza M Mushiba, Maha S Zaki, Mahmoud R Fassad, Majid Alfadhel, Saji Alexander, Yasser Sabr, Samia Temtamy, Alka V Ekbote, Samira Ismail, Gamal Ahmed Hosny, Ghada A Otaify, Khalda Amr, Saeed Al Tala, Arif O Khan, Tamer Rizk, Aida Alaqeel, Abdulmonem Alsiddiky, Ankur Singh, Seema Kapoor, Amal Alhashem, Eissa Faqeih, Ranad Shaheen, Fowzan S Alkuraya
PurposeTo describe our experience with a large cohort (411 patients from 288 families) of various forms of skeletal dysplasia who were molecularly characterized.MethodsDetailed phenotyping and next-generation sequencing (panel and exome).ResultsOur analysis revealed 224 pathogenic/likely pathogenic variants (54 (24%) of which are novel) in 123 genes with established or tentative links to skeletal dysplasia. In addition, we propose 5 genes as candidate disease genes with suggestive biological links (WNT3A, SUCO, RIN1, DIP2C, and PAN2)...
April 5, 2018: Genetics in Medicine: Official Journal of the American College of Medical Genetics
Hanbo Chen, Joanna M Laba, R Gabriel Boldt, Christopher D Goodman, David A Palma, Suresh Senan, Alexander V Louie
PURPOSE: As no completed randomized trials of surgery versus stereotactic ablative radiation therapy (SABR) in patients with early-stage non-small cell lung cancer are available, numerous propensity score studies have attempted to mimic the setting of clinical trials using nonrandomized data. We performed a meta-analysis of propensity score studies comparing SABR and surgery. METHODS AND MATERIALS: The MEDLINE and Embase databases were queried up to December 2016...
May 1, 2018: International Journal of Radiation Oncology, Biology, Physics
Jie Zhong, Marcelo A Carignano, Sabre Kais, Xiao Cheng Zeng, Joseph S Francisco, Ivan Gladich
Conformational isomerism plays a central role in organic synthesis and biological processes, however the effective control of the isomerization processes still remains challenging and elusive. Here, we propose a novel paradigm for conformational control of isomerization in condensed phase in which the polarity of the solvent determines the relative concentration of conformers at the interfacial and bulk regions. By the use of state-of-the-art molecular dynamics simulations of glyoxal in different solvents, we demonstrate that the isomerization process is dipole driven: the solvent favors conformational changes towards conformers having molecular dipoles that better match its polar character...
April 5, 2018: Journal of the American Chemical Society
Eunji Kim, Hong-Gyun Wu, Jong Min Park, Jung-In Kim, Hak Jae Kim, Hyun-Cheol Kang
Radiation-induced lung damage is an important treatment-related toxicity after lung stereotactic ablative radiotherapy (SABR). After implementing a tri-60Co magnetic-resonance image guided system, ViewRayTM, we compared the associated early radiological lung density changes to those associated with a linear accelerator (LINAC). Eight patients treated with the tri-60Co system were matched 1:1 with patients treated with LINAC. Prescription doses were 52 Gy or 60 Gy in four fractions, and lung dose-volumetric parameters were calculated from each planning system...
2018: PloS One
Daniele Andreini, Daniela Trabattoni
No abstract text is available yet for this article.
February 2018: Journal of Thoracic Disease
Donna H Murrell, Joanna M Laba, Abigail Erickson, Barbara Millman, David A Palma, Alexander V Louie
BACKGROUND: Lung stereotactic ablative radiotherapy (SABR) is associated with low morbidity, however there is an increased risk of treatment-related toxicity in tumors directly abutting or invading the proximal bronchial tree, termed 'ultra-central' tumors. As there is no consensus regarding the optimal radiotherapy treatment regimen for these tumors, we performed a modeling study to evaluate the trade-offs between predicted toxicity and local control for commonly used high-precision dose-fractionation regimens...
April 2, 2018: Radiation Oncology
Oliver Edwin Holmes, Robert MacRae, Graham Cook, Peter Cross, Vimoj Nair, Horia Marginean, Jason R Pantarotto
Purpose: In this single institution retrospective study of patients with stage I medically inoperable non-small cell lung cancer (NSCLC) treated with stereotactic ablative radiotherapy (SABR) we attempt to model overall survival (OS) using initial prognostic variables with specific attention on the Charlson co-morbidity index (CCI). Methods: Between 2008 and 2013, 335 patients with medically inoperable stage I NSCLC were treated with SABR or hypofractionated radiotherapy (50-60 Gy in at least 5 Gy or 4 Gy fractions respectively) at our institution...
August 2017: Clinical and Translational Radiation Oncology
C R Sacha, I Dimitriadis, G Christou, I Souter, C L Bormann
PURPOSE: To evaluate the differences in implantation and pregnancy rates when embryo transfer occurs on D2 versus D3 in women with a low yield of fertilized oocytes. METHODS: A total of 156 IVF/ICSI cycles from 141 women at an academic fertility center were analyzed in a retrospective fashion. Women with a low number of fertilized oocytes (≤ 2 two pronuclei (2PN) stage zygotes) who had their fresh embryo transfer on D2 or D3 were included in the study. Positive pregnancy test per IVF cycle (PPT), clinical pregnancy rate (CPR), spontaneous abortion rate (SABR), and implantation rate (IMPR) were the main outcome measures assessed...
March 27, 2018: Journal of Assisted Reproduction and Genetics
Yasir Alayed, Patrick Cheung, Geordi Pang, Alexandre Mamedov, Laura D'Alimonte, Andrea Deabreu, Kristina Commisso, Angela Commisso, Liang Zhang, Harvey C Quon, Hima Bindu Musunuru, Joelle Helou, D Andrew Loblaw
PURPOSE: Optimal prostate SABR dose-fractionation is unknown. This study compares long-term outcomes from two prospective trials. METHODS: Study1 patients had low-risk PCa and received 35 Gy/5. Study2 patients had low/intermediate-risk PCa and received 40 Gy/5. Biochemical failure (BF) was defined as nadir + 2. RESULTS: 114 patients were included (study1, n = 84; study2, n = 30). Median follow-up was 9.6 years and 6.9 years...
March 24, 2018: Radiotherapy and Oncology: Journal of the European Society for Therapeutic Radiology and Oncology
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