Biao Feng, Gang Chen, Xiufen Zheng, Hongtao Sun, Xusheng Zhang, Zhu-Xu Zhang, Ying Xiang, Thomas E Ichim, Bertha Garcia, Patrick Luke, Anthony M Jevnikar, Wei-Ping Min
BACKGROUND: Nuclear factor kappaB (NF-kappaB) has been found to be critical to the pathogenesis of renal ischemia-reperfusion injury (IRI). Using small interfering RNA (siRNA) to silence the expression of RelB, a component of the transcription factors Rel/nuclear factor kappaB, may protect renal IRI. Here, we report an siRNA-based treatment of preventing IRI. METHODS: Renal IRI was induced in mice by clamping the left renal pedicle for 25 or 35 min. The therapeutic effects of siRNA were evaluated in renal function, histologic examination, and overall survival after lethal IRI...
May 15, 2009: Transplantation