Chen Zhu, Karen O Dixon, Kathleen Newcomer, Guangxiang Gu, Sheng Xiao, Sarah Zaghouani, Markus A Schramm, Chao Wang, Huiyuan Zhang, Kouichiro Goto, Elena Christian, Manu Rangachari, Orit Rosenblatt-Rosen, Hitoshi Okada, Tak Mak, Meromit Singer, Aviv Regev, Vijay Kuchroo
T cell exhaustion has been associated with poor prognosis in persistent viral infection and cancer. Conversely, in the context of autoimmunity, T cell exhaustion has been favorably correlated with long-term clinical outcome. Understanding the development of exhaustion in autoimmune settings may provide underlying principles that can be exploited to quell autoreactive T cells. Here, we demonstrate that the adaptor molecule Bat3 acts as a molecular checkpoint of T cell exhaustion, with deficiency of Bat3 promoting a profound exhaustion phenotype, suppressing autoreactive T cell-mediated neuroinflammation...
April 2021: Science Advances