keyword
https://read.qxmd.com/read/38092723/the-chromatin-remodeling-protein-brg1-regulates-hsc-myofibroblast-differentiation-and-liver-fibrosis
#1
JOURNAL ARTICLE
Yuwen Zhu, Aoqi Kang, Yameng Kuai, Yan Guo, Xiulian Miao, Li Zhu, Ming Kong, Nan Li
Excessive fibrogenic response in the liver disrupts normal hepatic anatomy and function heralding such end-stage liver diseases as hepatocellular carcinoma and cirrhosis. Myofibroblasts, derived primarily from hepatic stellate cells (HSCs), are the effector of liver fibrosis. In the present study we investigated the mechanism by which Brahma-related gene 1 (BRG1, encoded by Smarca4) regulates HSC-myofibroblast transition and the implication in intervention against liver fibrosis. We report that BRG1 expression was elevated during HSC maturation in cell culture, in animal models, and in human cirrhotic liver biopsy specimens...
December 14, 2023: Cell Death & Disease
https://read.qxmd.com/read/36045679/bag6-negatively-regulates-the-rlr-signaling-pathway-by-targeting-visa-mavs
#2
JOURNAL ARTICLE
Jing-Ping Huang, Jing Li, Yan-Ping Xiao, Liang-Guo Xu
The virus-induced signaling adaptor protein VISA (also known as MAVS, ISP-1, Cardif) is a critical adaptor protein in the innate immune response to RNA virus infection. Upon viral infection, VISA self-aggregates to form a sizeable prion-like complex and recruits downstream signal components for signal transduction. Here, we discover that BAG6 (BCL2-associated athanogene 6, formerly BAT3 or Scythe) is an essential negative regulator in the RIG-I-like receptor signaling pathway. BAG6 inhibits the aggregation of VISA by promoting the K48-linked ubiquitination and specifically attenuates the recruitment of TRAF2 by VISA to inhibit RLR signaling...
2022: Frontiers in Immunology
https://read.qxmd.com/read/34968777/down-regulation-of-hla-b-associated-transcript-3-impairs-the-tumoricidal-effect-of-natural-killer-cells-through-promoting-the-t-cell-immunoglobulin-and-mucin-domain-containing-3-signaling-in-a-mouse-head-and-neck-squamous-cell-carcinoma-model
#3
JOURNAL ARTICLE
Jiyong Yang, Jun Xiang, Meiling Zhu, Yuman Zhao, Lei Zhou, Binbin Hu, Cheng Wang
Head and neck squamous cell carcinoma (HNSCC) arises from the malignant mucosal epithelium of the oral cavity, pharynx, and larynx. Natural killer (NK) cells are fundamental immune cells shaping the anti-HNSCC response. Elucidation of the regulatory mechanisms of NK cell activity is crucial for understanding anti-HNSCC immunity. In this study, we characterized the expression and function of HLA-B-associated transcript 3 (Bat3) in NK cells in a mouse HNSCC model. We found that Bat3 expression was down-regulated in HNSCC-infiltrating NK cells...
July 30, 2021: Immunobiology
https://read.qxmd.com/read/34593622/immune-cell-and-tumor-cell-derived-cxcl10-is-indicative-of-immunotherapy-response-in-metastatic-melanoma
#4
JOURNAL ARTICLE
Robin Reschke, Jovian Yu, Blake Flood, Emily F Higgs, Ken Hatogai, Thomas F Gajewski
A T cell-inflamed tumor microenvironment is characterized by the accumulation and local activation of CD8+ T cells and Bat3-lineage dendritic cells, which together are associated with clinical response to anti-programmed cell death protein 1 (anti-PD-1)-based immunotherapy. Preclinical models have demonstrated a crucial role for the chemokine CXCL10 in the recruitment of effector CD8+ T cells into the tumor site, and a chemokine gene signature is also seen in T cell-inflamed tumors from patients. However, the cellular source of CXCL10 in human solid tumors is not known...
September 2021: Journal for Immunotherapy of Cancer
https://read.qxmd.com/read/34523930/regulation-of-fibroblast-activation-protein-%C3%AE-expression-focus-on-intracellular-protein-interactions
#5
REVIEW
Lucienne Juillerat-Jeanneret, Petra Tafelmeyer, Dela Golshayan
The prolyl-specific peptidase fibroblast activation protein-α (FAP-α) is expressed at very low or undetectable levels in nondiseased human tissues but is selectively induced in activated (myo)fibroblasts at sites of tissue remodeling in fibrogenic processes. In normal regenerative processes involving transient fibrosis FAP-α+ (myo)fibroblasts disappear from injured tissues, replaced by cells with a normal FAP-α- phenotype. In chronic uncontrolled pathological fibrosis FAP-α+ (myo)fibroblasts permanently replace normal tissues...
October 14, 2021: Journal of Medicinal Chemistry
https://read.qxmd.com/read/33931442/tim-3-adaptor-protein-bat3-is-a-molecular-checkpoint-of-t-cell-terminal-differentiation-and-exhaustion
#6
JOURNAL ARTICLE
Chen Zhu, Karen O Dixon, Kathleen Newcomer, Guangxiang Gu, Sheng Xiao, Sarah Zaghouani, Markus A Schramm, Chao Wang, Huiyuan Zhang, Kouichiro Goto, Elena Christian, Manu Rangachari, Orit Rosenblatt-Rosen, Hitoshi Okada, Tak Mak, Meromit Singer, Aviv Regev, Vijay Kuchroo
T cell exhaustion has been associated with poor prognosis in persistent viral infection and cancer. Conversely, in the context of autoimmunity, T cell exhaustion has been favorably correlated with long-term clinical outcome. Understanding the development of exhaustion in autoimmune settings may provide underlying principles that can be exploited to quell autoreactive T cells. Here, we demonstrate that the adaptor molecule Bat3 acts as a molecular checkpoint of T cell exhaustion, with deficiency of Bat3 promoting a profound exhaustion phenotype, suppressing autoreactive T cell-mediated neuroinflammation...
April 2021: Science Advances
https://read.qxmd.com/read/32986360/expression-analysis-of-fyn-and-bat3-signal-transduction-molecules-in-patients-with-chronic-lymphocytic-leukemia
#7
JOURNAL ARTICLE
Fereshteh Hosseini-Valiki, Saeid Taghiloo, Golvash Tavakolian, Omolbanin Amjadi, Mohsen Tehrani, Akbar Hedayatizadeh-Omran, Reza Alizadeh-Navaei, Ehsan Zaboli, Ramin Shekarriz, Hossein Asgarian-Omran
BACKGROUND: Chronic lymphocytic leukemia (CLL) is correlated with defects in T-cell function resulting imparity in antitumor immune responses. Tim-3 is a co-inhibitory immune checkpoint receptor expressed on exhausted T-cells during tumor progression. Fyn and Bat3 are two important adaptor molecules involved in inhibition and activation of Tim-3 downstream signaling, respectively. In this study, the expression of Tim-3, Fyn, and Bat3 mRNA was evaluated in CLL patients. METHODS: Peripheral blood mononuclear cells (PBMCs) were isolated from 54 patients with CLL and 34 healthy controls...
September 1, 2020: Asian Pacific Journal of Cancer Prevention: APJCP
https://read.qxmd.com/read/32332095/chronic-treatment-with-the-complex-i-inhibitor-mpp-depletes-endogenous-pten-induced-kinase-1-pink1-via-upregulation-of-bcl-2-associated-athanogene-6
#8
JOURNAL ARTICLE
Manish Verma, Jianhui Zhu, Kent Z Q Wang, Charleen T Chu
Mitochondrial dysfunction is implicated in sporadic and familial Parkinson's disease (PD). However, the mechanisms that impair homeostatic responses to mitochondrial dysfunction remain unclear. Previously, we found that chronic, low dose administration of the mitochondrial complex I inhibitor 1-methyl-4-phenylpyridinium (MPP+) dysregulates mitochondrial fission-fusion, mitophagy and mitochondrial biogenesis. Given that PTEN-induced kinase 1 (PINK1) regulates mitochondrial function, dynamics and turnover, we hypothesized that alterations in endogenous PINK1 levels contribute to depletion of mitochondria during chronic complex I injury...
April 24, 2020: Journal of Biological Chemistry
https://read.qxmd.com/read/31911483/bag6-contributes-to-glucose-uptake-by-supporting-the-cell-surface-translocation-of-the-glucose-transporter-glut4
#9
JOURNAL ARTICLE
Setsuya Minami, Naoto Yokota, Hiroyuki Kawahara
Defective translocation of glucose transporter 4 (GLUT4) to the cell surface is a key feature of insulin resistance in type 2 diabetes. Therefore, elucidating the mechanism of GLUT4 translocation is of primary importance. The mammalian Bag6/Bat3 gene has been suggested to be linked with potential obesity- and diabetes-associated loci, while its function in the control of glucose incorporation into the cytoplasm has not been investigated. In this study, we established a series of cell lines that stably expressed GLUT4 with three tandem repeats of the antigenic peptide inserted into its 1st extracellular loop...
January 7, 2020: Biology Open
https://read.qxmd.com/read/31647545/hla-b-associated-transcript-3-bat3-stabilizes-and-activates-p53-in-a-hausp-dependent-manner
#10
JOURNAL ARTICLE
Rui Zhang, Di Cui, Teng Xue, Yue Lang, Yunfan Zhang, Lianjie Li, Haili Sun, Yu Kuang, Gebin Li, Jun Tang
The p53 pathway is a highly complex signaling network including several key regulators. HAUSP is a critical component of the p53 pathway acting as a deubiquitinase for both p53 and its key repressor Mdm2. Here, we identified a novel HAUSP-interacting protein, HLA-B-associated transcript 3 (Bat3) and found it to be capable of inducing p53 stabilization and activation via a HAUSP-dependent mechanism, resulting in cell growth inhibition. Surprisingly, the deubiquitylating enzymatic activity of HAUSP was not required for this phenomenon...
February 20, 2020: Journal of Molecular Cell Biology
https://read.qxmd.com/read/31534536/exosome-dependent-immune-surveillance-at-the-metastatic-niche-requires-bag6-and-cbp-p300-dependent-acetylation-of-p53
#11
JOURNAL ARTICLE
Maximiliane Schuldner, Bastian Dörsam, Olga Shatnyeva, Katrin S Reiners, Andriy Kubarenko, Hinrich P Hansen, Florian Finkernagel, Katrin Roth, Sebastian Theurich, Andrea Nist, Thorsten Stiewe, Annette Paschen, Gero Knittel, Hans C Reinhardt, Rolf Müller, Michael Hallek, Elke Pogge von Strandmann
Extracellular vesicles released by tumor cells contribute to the reprogramming of the tumor microenvironment and interfere with hallmarks of cancer including metastasis. Notably, melanoma cell-derived EVs are able to establish a pre-metastatic niche in distant organs, or on the contrary, exert anti-tumor activity. However, molecular insights into how vesicles are selectively packaged with cargo defining their specific functions remain elusive. Methods : Here, we investigated the role of the chaperone Bcl2-associated anthogene 6 (BAG6, synonym Bat3) for the formation of pro- and anti-tumor EVs...
2019: Theranostics
https://read.qxmd.com/read/31416091/echolocation-in-a-nocturnal-primate
#12
JOURNAL ARTICLE
Sharon Gursky
Recently it has been noted that Gursky's spectral tarsier emits ultrasonic calls. Because high-frequency sounds are capable of travelling only short distances, their function is limited by the distance the sound can be discerned. One possible function for these short-distance, high-frequency sounds is that they might be used by the tarsiers to navigate throughout their environment. I conducted this study at Tangkoko Nature Reserve in Sulawesi, Indonesia, from May to August 2017. Using the focal follows, I recorded the start of each locomotor activity to the nearest second...
August 15, 2019: Folia Primatologica; International Journal of Primatology
https://read.qxmd.com/read/31142599/a-deficit-of-ceacam-1-expressing-t-lymphocytes-supports-inflammation-in-primary-progressive-multiple-sclerosis
#13
JOURNAL ARTICLE
Federica Piancone, Marina Saresella, Ivana Marventano, Francesca La Rosa, Domenico Caputo, Laura Mendozzi, Marco Rovaris, Mario Clerici
The immune regulatory mechanisms that modulate Th1 and Th17 immune responses are altered in multiple sclerosis (MS). The inhibitory TIM-3/Gal-9 pathway, in particular, is impaired in primary progressive MS (PPMS). Recent results showed that carcinoembryonic Ag-related cell adhesion molecule 1 (CEACAM-1), a molecule expressed on activated T lymphocytes, endows TIM-3 with inhibitory function and facilitates the maturation and cell surface expression of TIM-3. We analyzed by flow cytometry CEACAM-1 expression on myelin basic protein (MBP)-stimulated CD4+ and CD8+ T lymphocytes of 56 MS patients with a diagnosis of either PPMS ( n = 16), relapsing-remitting MS ( n = 20), or benign MS ( n = 20) and 40 age- and sex-matched healthy controls...
July 1, 2019: Journal of Immunology
https://read.qxmd.com/read/31125507/bag6-deficiency-induces-mis-distribution-of-mitochondrial-clusters-under-depolarization
#14
JOURNAL ARTICLE
Mizuki Hayashishita, Hiroyuki Kawahara, Naoto Yokota
Accumulation of damaged mitochondria is implicated in a number of neurodegenerative disorders, including Parkinson's disease. Therefore, the machinery for mitochondrial quality control is important for the prevention of such diseases. It has been reported that Parkin- and p62/sequestosome 1 (SQSTM1)-mediated clustering and subsequent elimination of damaged mitochondria (termed mitophagy) are critical for maintaining the quality of mitochondria under stress induced by uncoupling agents such as carbonyl cyanide m-chlorophenyl hydrazone...
July 2019: FEBS Open Bio
https://read.qxmd.com/read/30804014/cytoplasmic-control-of-rab-family-small-gtpases-through-bag6
#15
JOURNAL ARTICLE
Toshiki Takahashi, Setsuya Minami, Yugo Tsuchiya, Kazu Tajima, Natsumi Sakai, Kei Suga, Shin-Ichi Hisanaga, Norihiko Ohbayashi, Mitsunori Fukuda, Hiroyuki Kawahara
Rab family small GTPases are master regulators of distinct steps of intracellular vesicle trafficking in eukaryotic cells. GDP-bound cytoplasmic forms of Rab proteins are prone to aggregation due to the exposure of hydrophobic groups but the machinery that determines the fate of Rab species in the cytosol has not been elucidated in detail. In this study, we find that BAG6 (BAT3/Scythe) predominantly recognizes a cryptic portion of GDP-associated Rab8a, while its major GTP-bound active form is not recognized...
February 25, 2019: EMBO Reports
https://read.qxmd.com/read/30485264/rhinovirus-infections-change-dna-methylation-and-mrna-expression-in-children-with-asthma
#16
JOURNAL ARTICLE
Martin Pech, Markus Weckmann, Inke R König, Andre Franke, Femke-Anouska Heinsen, Brian Oliver, Isabell Ricklefs, Oliver Fuchs, Klaus Rabe, Gesine Hansen, Erika V Mutius, Matthias V Kopp
Human rhinovirus infection (HRVI) plays an important role in asthma exacerbations and is thought to be involved in asthma development during early childhood. We hypothesized that HRVI causes differential DNA methylation and subsequently differential mRNA expression in epithelial cells of children with asthma. Primary nasal epithelial cells from children with (n = 10) and without (n = 10) asthma were cultivated up to passage two and infected with Rhinovirus-16 (RV-16). HRVI-induced genome-wide differences of DNA methylation in asthmatics (vs...
2018: PloS One
https://read.qxmd.com/read/29706626/long-non-coding-rna-lnc-tim3-exacerbates-cd8-t-cell-exhaustion-via-binding-to-tim-3-and-inducing-nuclear-translocation-of-bat3-in-hcc
#17
JOURNAL ARTICLE
Jie Ji, Yin Yin, Huanyu Ju, Xiaoliang Xu, Wei Liu, Qiang Fu, Jiaojiao Hu, Xudong Zhang, Beicheng Sun
Although one of the first comprehensive examinations of long non-coding RNA (lncRNA) expression was performed in human CD8 T lymphocytes, little is known about their roles in CD8 T cells functions during the progression of hepatocellular carcinoma (HCC). Here, we show that Lnc-Tim3 is upregulated and negatively correlates with IFN-γ and IL-2 production in tumor-infiltrating CD8 T cells of HCC patients. Lnc-Tim3 plays a pivotal role in stimulating CD8 T exhaustion and the survival of the exhausted CD8 T cells...
May 1, 2018: Cell Death & Disease
https://read.qxmd.com/read/29599678/the-usefulness-of-the-basophil-activation-test-in-monitoring-specific-immunotherapy-with-house-dust-mite-allergens
#18
JOURNAL ARTICLE
Ewa M Czarnobilska, Małgorzata Bulanda, Radosław Śpiewak
Introduction: In clinical practice, reliable tools for monitoring specific immunotherapy (SIT) are of utmost importance. Aim: To assess the usefulness of the basophil activation test (BAT) in monitoring SIT in paediatric patients with allergy to house dust mites (HDM). Material and methods: Thirty-one children qualified for SIT with HDM, of whom 21 completed the SIT during the observation period. The BAT was carried out prior to commencing the SIT (time point BAT1) and upon finishing the initial pack of allergy vaccine (cumulative dose of allergen 12487...
February 2018: Postȩpy Dermatologii i Alergologii
https://read.qxmd.com/read/29110844/genetic-polymorphisms-and-lung-cancer-risk-evidence-from-meta-analyses-and-genome-wide-association-studies
#19
REVIEW
Caiyang Liu, Huijie Cui, Dongqing Gu, Min Zhang, Yanfei Fang, Siyu Chen, Mingshuang Tang, Ben Zhang, Huanwen Chen
A growing number of studies investigating the association between Single Nucleotide Polymorphisms (SNPs) and lung cancer risk have been published since over a decade ago. An updated integrative assessment on the credibility and strength of the associations is required. We searched PubMed, Medline, and Web of Science on or before August 29th , 2016. A total of 198 articles were deemed eligible for inclusion, which addressed the associations between 108 variants and lung cancer. Among the 108 variants, 63 were reported to be significantly associated with lung cancer while the remaining 45 were reported non-significant...
November 2017: Lung Cancer: Journal of the International Association for the Study of Lung Cancer
https://read.qxmd.com/read/29109174/-orientia-tsutsugamushi-modulates-endoplasmic-reticulum-associated-degradation-to-benefit-its-growth
#20
JOURNAL ARTICLE
Kyle G Rodino, Lauren VieBrock, Sean M Evans, Hong Ge, Allen L Richards, Jason A Carlyon
Orientia tsutsugamushi , an obligate intracellular bacterium that is auxotrophic for the aromatic amino acids and histidine, causes scrub typhus, a potentially deadly infection that threatens one billion people. O. tsutsugamushi growth is minimal during the first 24 to 48 h of infection, but becomes logarithmic thereafter. How the pathogen modulates cellular functions to support its growth is poorly understood. The unfolded protein response (UPR) is a cytoprotective pathway that relieves endoplasmic reticulum (ER) stress by promoting ER-associated degradation (ERAD) of misfolded proteins...
November 6, 2017: Infection and Immunity
keyword
keyword
114147
1
2
Fetch more papers »
Fetching more papers... Fetching...
Remove bar
Read by QxMD icon Read
×

Save your favorite articles in one place with a free QxMD account.

×

Search Tips

Use Boolean operators: AND/OR

diabetic AND foot
diabetes OR diabetic

Exclude a word using the 'minus' sign

Virchow -triad

Use Parentheses

water AND (cup OR glass)

Add an asterisk (*) at end of a word to include word stems

Neuro* will search for Neurology, Neuroscientist, Neurological, and so on

Use quotes to search for an exact phrase

"primary prevention of cancer"
(heart or cardiac or cardio*) AND arrest -"American Heart Association"

We want to hear from doctors like you!

Take a second to answer a survey question.