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John h stone IgG 4

Vikram Deshpande, Yoh Zen, John Kc Chan, Eunhee E Yi, Yasuharu Sato, Tadashi Yoshino, Günter Klöppel, J Godfrey Heathcote, Arezou Khosroshahi, Judith A Ferry, Rob C Aalberse, Donald B Bloch, William R Brugge, Adrian C Bateman, Mollie N Carruthers, Suresh T Chari, Wah Cheuk, Lynn D Cornell, Carlos Fernandez-Del Castillo, David G Forcione, Daniel L Hamilos, Terumi Kamisawa, Satomi Kasashima, Shigeyuki Kawa, Mitsuhiro Kawano, Gregory Y Lauwers, Yasufumi Masaki, Yasuni Nakanuma, Kenji Notohara, Kazuichi Okazaki, Ji Kon Ryu, Takako Saeki, Dushyant V Sahani, Thomas C Smyrk, James R Stone, Masayuki Takahira, George J Webster, Motohisa Yamamoto, Giuseppe Zamboni, Hisanori Umehara, John H Stone
IgG4-related disease is a newly recognized fibro-inflammatory condition characterized by several features: a tendency to form tumefactive lesions in multiple sites; a characteristic histopathological appearance; and-often but not always-elevated serum IgG4 concentrations. An international symposium on IgG4-related disease was held in Boston, MA, on 4-7 October 2011. The organizing committee comprising 35 IgG4-related disease experts from Japan, Korea, Hong Kong, the United Kingdom, Germany, Italy, Holland, Canada, and the United States, including the clinicians, pathologists, radiologists, and basic scientists...
September 2012: Modern Pathology: An Official Journal of the United States and Canadian Academy of Pathology, Inc
Arezou Khosroshahi, Vikram Deshpande, John H Stone
The rapidly emerging disorder now known as IgG(4)-related disease (IgG(4)-RD) includes a variety of clinical entities once regarded as being entirely separate diseases. Manifestations of IgG(4)-RD have now been reported in essentially all organ systems. Regardless of which organ is involved, tissue biopsies reveal striking histopathological similarities. The hallmark pathology findings are diffuse lymphoplasmacytic infiltrates, abundant IgG(4)-positive plasma cells, modest tissue eosinophilia, and extensive fibrosis...
December 2011: Current Rheumatology Reports
Vikram Deshpande, Arezou Khosroshahi, Gunnlaugur P Nielsen, Daniel L Hamilos, John H Stone
BACKGROUND: Eosinophilic angiocentric fibrosis (EAF) is an uncommon tumefactive lesion of the orbit and upper respiratory tract of unknown etiology. The condition is characterized histologically by concentric layers of fibrosis around small-caliber arteries and a mixed inflammatory infiltrate dominated by eosinophils. After the serendipitous observation of an elevated serum concentration of IgG4 in 1 patient with EAF, we investigated the hypothesis that EAF is an IgG4-related systemic disease...
May 2011: American Journal of Surgical Pathology
Arezou Khosroshahi, Donald B Bloch, Vikram Deshpande, John H Stone
OBJECTIVE: Patients with IgG4-related systemic disease (IgG4-RSD) frequently show an incomplete response to treatment with glucocorticoids and traditional disease-modifying antirheumatic drugs (DMARDs). B lymphocyte depletion is a therapeutic strategy known to be effective for pemphigus vulgaris, an autoimmune condition mediated by IgG4 autoantibodies. This study was performed to assess the clinical and serologic responses to B lymphocyte depletion therapy with rituximab in patients with IgG4-RSD...
June 2010: Arthritis and Rheumatism
Julia Turbiner Geyer, Judith A Ferry, Nancy L Harris, John H Stone, Lawrence R Zukerberg, Gregory Y Lauwers, Ben Z Pilch, Vikram Deshpande
BACKGROUND: Chronic sclerosing sialadenitis is a fibroinflammatory disease of the salivary glands, characteristically of the submandibular gland. One prior Asian study proposed that chronic sclerosing sialadenitis is a part of the spectrum of IgG4-associated disease. This association has not been confirmed in Western populations. We therefore, investigated the relationship between IgG4 and chronic sclerosing sialadenitis, and compared the histomorphologic features of this condition with those of chronic sialadenitis-not otherwise specified, Sjögren syndrome, and lymphoepithelial sialadenitis...
February 2010: American Journal of Surgical Pathology
Monica M McNeal, Susan C Stone, Mitali Basu, Judy A Bean, John D Clements, Barbara A Hendrickson, Anthony H-C Choi, Richard L Ward
Intranasal immunization of mice with chimeric VP6 and the adjuvant LT(R192G) consistently elicits >95% reductions in fecal rotavirus shedding following challenge. To determine the association between mucosal antibody and protection, we immunized BALB/c wt and J chain knockout (Jch-/-) mice with VP6 and either LT(R192G) or cholera toxin (CT). Both strains developed nearly equal levels of serum rotavirus IgG, but Jch-/- mice, which cannot transport dimeric IgA across epithelial cell surfaces, developed >4-fold higher levels of serum rotavirus IgA...
March 15, 2006: Virology
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