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https://www.readbyqxmd.com/read/29935202/a-new-conceptual-framework-for-the-therapy-by-optimized-multidimensional-pulses-of-therapeutic-activity-the-case-of-multiple-myeloma-model
#1
D Horvath, B Brutovsky
We developed simulation methodology to assess eventual therapeutic efficiency of exogenous multiparametric changes in a four-component cellular system described by the system of ordinary differential equations. The method is numerically implemented to simulate the temporal behavior of a cellular system of multiple myeloma cells. The problem is conceived as an inverse optimization task where the alternative temporal changes of selected parameters of the ordinary differential equations represent candidate solutions and the objective function quantifies the goals of the therapy...
June 20, 2018: Journal of Theoretical Biology
https://www.readbyqxmd.com/read/29934801/iscev-extended-protocol-for-the-dark-adapted-red-flash-erg
#2
Dorothy A Thompson, Kaoru Fujinami, Ido Perlman, Ruth Hamilton, Anthony G Robson
The International Society for Clinical Electrophysiology of Vision (ISCEV) standard for full-field electroretinography (ERG) describes a minimum procedure, but encourages more extensive testing. This ISCEV extended protocol describes an extension to the ERG standard, namely the dark-adapted (DA) red flash ERG. The DA red flash ERG can be incorporated conveniently within the ISCEV standard ERG protocol after a minimum of 20-min DA and recorded after the DA 0.01 ERG to a flash strength of 0.3 phot cd s m-2 , eliciting a waveform with two positive peaks in healthy individuals...
June 22, 2018: Documenta Ophthalmologica. Advances in Ophthalmology
https://www.readbyqxmd.com/read/29934653/quorum-sensing-inhibitory-activity-of-the-metabolome-from-endophytic-kwoniella-sp-py016-characterization-and-hybrid-model-based-optimization
#3
Abhirup Mookherjee, Ramalingam Dineshkumar, Nithya N Kutty, Tarun Agarwal, Ramkrishna Sen, Adinpunya Mitra, Tapas Kumar Maiti, Mrinal Kumar Maiti
Quorum sensing, the microbial communication system, is gaining importance as a therapeutic target against pathogens. The two key reasons for the rising demand of quorum sensing (QS) inhibitory molecules are low selective pressure to develop resistance by pathogens and possibility of more species-specific effects. Due to complex interactions in a unique niche of live plant tissues, endophytes, as a survival mechanism, potentially produce various bioactive compounds such as QS inhibitors. We report the isolation of an endophytic fungus Kwoniella sp...
June 22, 2018: Applied Microbiology and Biotechnology
https://www.readbyqxmd.com/read/29934140/wall-slip-for-complex-liquids-phenomenon-and-its-causes
#4
REVIEW
A Ya Malkin, S A Patlazhan
In this review, we tried to qualify different types and mechanisms of wall slip phenomenon, paying particular attention to the most recent publications and issues. The review covers all type of fluids - homogeneous low molecular weight liquids, polymer solution, multi-component dispersed media, and polymer melts. We focused on two basic concepts - fluid-solid wall interaction and shear-induced fluid-to-solid transitions - which are the dominant mechanisms of wall slip. In the first part of the review, the theoretical and numerical studies of correlation of wetting properties and wall slip of low molecular weight liquids and polymeric fluids are reviewed along with some basic experimental results...
June 15, 2018: Advances in Colloid and Interface Science
https://www.readbyqxmd.com/read/29933698/biomedical-platform-development-of-chlorophyll-based-extract-for-topic-photodynamic-therapy-mechanical-and-spectroscopic-properties
#5
Katieli da Silva Souza Campanholi, Gustavo Braga, Jéssica Bassi da Silva, Nicola Leone da Rocha, Lizziane Maria Belloto de Francisco, Évelin Lemos de Oliveira, Marcos Luciano Bruschi, Lidiane Hoshino, Francielle Sato, Noboru Hioka, Wilker Caetano
Photodynamic therapy (PDT) is a therapeutic modality that has shown effectiveness in the inactivation of cancer cell lines and microorganisms. Treatment consists of activating the photosensitizer (PS) upon light irradiation of adequate wavelength. After reaching the excited state, the PS can handle the inter-system conversion through energy transfer to the molecular oxygen, generating reactive oxygen species. This especially applies to singlet oxygen (1O2), which is responsible for the selective destruction of the sick tissue...
June 22, 2018: Langmuir: the ACS Journal of Surfaces and Colloids
https://www.readbyqxmd.com/read/29933514/malate-valves-old-shuttles-with-new-perspectives
#6
REVIEW
Jennifer Selinski, Renate Scheibe
Malate valves act as powerful systems for balancing the ATP/NAD(P)H ratio required in various subcellular compartments in plant cells. As components of malate valves, isoforms of malate dehydrogenases (MDHs) and dicarboxylate translocators catalyze the reversible interconversion of malate and oxaloacetate and their transport. Depending on the coenzyme specificity of the MDH isoforms, either NADH or NADPH can be transported indirectly. Arabidopsis thaliana possesses nine genes encoding MDH isoenzymes: Activities of NAD-dependent MDHs have been detected in mitochondria, peroxisomes, cytosol and plastids, respectively...
June 22, 2018: Plant Biology
https://www.readbyqxmd.com/read/29933112/bcl3-regulates-rankl-induced-osteoclastogenesis-by-interacting-with-traf6-in-bone-marrow-derived-macrophages
#7
Kun Wang, Shuai Li, Yong Gao, Xiaobo Feng, Wei Liu, Rongjin Luo, Yu Song, JiTu, Yingle Liu, Cao Yang
OBJECTIVE: Tumor necrosis factor receptor-associated factor 6 (TRAF6) is an essential component of the signaling complex that mediates osteoclastogenesis. As an adaptor protein of E3 ligase function, TRAF6 regulates NF-κB signaling via TAK1 and I-κB kinase (IKK) activation. Here, we investigated novel mechanisms by which TRAF6 signaling is regulated under receptor activator of nuclear factor-κB ligand (RANKL)-induced osteoclastogenesis. DESIGN: A yeast two-hybrid screen system identified cellular factors that interact with TRAF6...
June 19, 2018: Bone
https://www.readbyqxmd.com/read/29932851/complex-adaptive-systems-a-new-approach-for-understanding-health-practices
#8
Tim Gomersall
This article explores the potential of complex adaptive systems theory to inform behaviour change research. A complex adaptive system describes a collection of heterogeneous agents interacting within a particular context, adapting to each other's actions. In practical terms, this implies that behaviour change is 1) socially and culturally situated; 2) highly sensitive to small baseline differences in individuals, groups, and intervention components; and 3) determined by multiple components interacting "chaotically"...
June 22, 2018: Health Psychology Review
https://www.readbyqxmd.com/read/29932458/the-added-value-of-studying-embodied-responses-in-couple-therapy-research-a-case-study
#9
Aarno Laitila, Berta Vall, Markku Penttonen, Anu Karvonen, Virpi-Liisa Kykyri, Valeri Tsatsishvili, Jukka Kaartinen, Jaakko Seikkula
This article reports on the added value of embodied responses identified through sympathetic nervous system (SNS) activity in couple therapy research. It focuses on moments of change and the timing of therapeutic interventions or therapeutic moves in a couple therapy session. The data for this single-case study comprise couple therapy process videotapes recorded in a multi-camera setting, and measurements of participants' SNS activity. The voluntary participants were a marital couple in their late thirties and two middle-aged male psychotherapists...
June 22, 2018: Family Process
https://www.readbyqxmd.com/read/29932195/experimental-evaluation-of-additional-short-ranged-repulsion-in-structural-oscillation-forces
#10
Sebastian Schön, Regine von Klitzing
The paper addresses additional short ranged repulsion in structural oscillation forces between silica surfaces across a suspension of silica nanoparticles. Fit and prediction of the structural oscillation forces usually involve an exponentially decreasing harmonic as introduced by Israelachvili [Israelachvili, Intermolecular & surface forces, Academic Press, San Diego, USA, 1985]. Recently we demonstrated, for aqueous suspensions of silica nanoparticles at various concentrations, that this fit equation is insufficient to describe the structural oscillation forces in its whole range [Schön et al...
June 22, 2018: Soft Matter
https://www.readbyqxmd.com/read/29931388/analytical-band-centrifugation-revisited
#11
Cornelia M Schneider, Helmut Cölfen
Analytical band centrifugation (ABC) is a powerful tool for the analysis of macromolecules and nanoparticles. Although it offers several advantages over the sedimentation velocity (SV) experiment like a physical separation of the individual components and the possibility to perform chemical reactions, its analysis is still very restricted. Therefore, we investigated the integration of ABC data as an alternative approach, as this results in data similar to SV, which can then be evaluated by many established evaluation programs...
June 21, 2018: European Biophysics Journal: EBJ
https://www.readbyqxmd.com/read/29931265/transcriptomic-insights-into-the-loss-of-vision-in-moln%C3%A3-r-j%C3%A3-nos-cave-s-crustaceans
#12
Jorge L Pérez-Moreno, Gergely Balázs, Heather D Bracken-Grissom
Animals that inhabit subterranean environments often undergo various distinct phenotypic modifications (referred to as "troglomorphy") as they transition to life in perpetual darkness. However, the molecular basis behind troglomorphy remains poorly understood, particularly in regards to the mechanisms involved in the reduction and/or loss of traits at the transcriptomic level. In this study we investigate the transcriptional basis behind vision loss in populations of cave-dwelling crustaceans. We employ phylogenetic and transcriptomic methods on surface and cave-adapted populations of an emerging model species for biospeleology, the isopod Asellus aquaticus (Linnaeus, 1758), and the amphipod Niphargus hrabei S...
June 20, 2018: Integrative and Comparative Biology
https://www.readbyqxmd.com/read/29931021/robust-nanocoatings-based-on-ionic-silicones
#13
Agnieszka Puciul-Malinowska, Szczepan Zapotoczny
Two oppositely charged water-soluble oligosiloxanes with the same main chain were synthesized and used for the formation of multilayer nanocoatings. In spite of low molecular weight of the components, due to entropic reasons, linearly growing and robust films with a hydrophilic surface were formed for the first time. The multilayer films were found to be resistant to high temperature water treatment undergoing only reversible swelling and no surface recovery was observed after prolonged exposure to air indicating permanent water wettability of these silicone-based coatings...
June 22, 2018: Nanoscale
https://www.readbyqxmd.com/read/29930971/detecting-risk-of-low-health-literacy-in-disadvantaged-populations-using-area-based-measures
#14
Andrew J Knighton, Kimberly D Brunisholz, Samuel T Savitz
Introduction: Socio-economic status (SES) and low health literacy (LHL) are closely correlated. Both are directly associated with clinical and behavioral risk factors and healthcare outcomes. Learning healthcare systems are introducing small-area measures to address the challenges associated with maintaining patient-reported measures of SES and LHL. This study's purpose was to measure the association between two available census block measures associated with SES and LHL. Understanding the relationship can guide the identification of a multi-purpose area based measure for delivery system use...
December 15, 2017: EGEMS
https://www.readbyqxmd.com/read/29930894/loosely-bound-low-loss-surface-plasmons-in-hyperbolic-metamaterial
#15
Yu Shi, Hong Koo Kim
Surface plasmons (SPs) carry electromagnetic energy in the form of collective oscillation of electrons at metal surface and commonly demonstrate two important features: strong lateral confinement and short propagation lengths. In this work we have investigated the trade-off relationship existing between propagation length and lateral confinement of SP fields in a hyperbolic metamaterial system, and explored loosening of lateral confinement as a means of increasing propagation length. By performing finite-difference time-domain analysis of Ag/SiO2 thin-film stacked structure we demonstrate long range (~ 100 mm) propagation of SPs at 1...
2018: Nano Convergence
https://www.readbyqxmd.com/read/29929814/resident-vitality-in-34-programs-at-14-academic-health-systems-insights-for-educating-physicians-and-surgeons-for-the-future
#16
Linda H Pololi, Arthur T Evans, Janet T Civian, Sandy Shea, Robert T Brennan
OBJECTIVE: To clarify our understanding of how the culture of residency training influences the well-being of residents, this study reports on the vitality of residents at 34 programs across the United States and identifies characteristics of the programs, institutions and residents that are associated with high resident vitality. DESIGN: In 2014 to 2015, residents nationally were surveyed using the validated C - Change Resident Survey. The survey assessed residents' vitality and 12 other dimensions that characterize residents' perspectives of the culture of the residency training programs: Self-efficacy, Institutional/program support, Relationships/inclusion/trust, Values alignment, Ethical/moral distress, Respect, Leadership aspirations, Mentoring, Work-life integration, Gender equity, Racial/ethnic minority equity, and self-assessed Competencies...
June 18, 2018: Journal of Surgical Education
https://www.readbyqxmd.com/read/29929335/future-climate-and-cryosphere-impacts-on-the-hydrology-of-a-scarcely-gauged-catchment-on-the-jhelum-river-basin-northern-pakistan
#17
Muhammad Azmat, Muhammad Uzair Qamar, Christian Huggel, Ejaz Hussain
Streamflow projections are fundamental sources for future water resources strategic planning and management, particularly in high-altitude scarcely-gauged basins located in high mountain Asia. Therefore, quantification of the climate change impacts on major hydrological components (evapotranspiration, soil water storage, snowmelt-runoff, rainfall-runoff and streamflow) is of high importance and remains a challenge. For this purpose, we analysed general circulation models (GCMs) using a multiple bias correction approach and two different hydrological models i...
October 15, 2018: Science of the Total Environment
https://www.readbyqxmd.com/read/29928526/development-and-validation-of-a-practical-instrument-for-injury-prevention-the-occupational-safety-and-health-monitoring-and-assessment-tool-osh-mat
#18
Yi Sun, Martin Arning, Frank Bochmann, Jutta Börger, Thomas Heitmann
Background: The Occupational Safety and Health Monitoring and Assessment Tool (OSH-MAT) is a practical instrument that is currently used in the German woodworking and metalworking industries to monitor safety conditions at workplaces. The 12-item scoring system has three subscales rating technical, organizational, and personnel-related conditions in a company. Each item has a rating value ranging from 1 to 9, with higher values indicating higher standard of safety conditions. Methods: The reliability of this instrument was evaluated in a cross-sectional survey among 128 companies and its validity among 30,514 companies...
June 2018: Safety and Health At Work
https://www.readbyqxmd.com/read/29928150/face-to-face-versus-online-training-for-the-interpretation-of-findings-in-the-fiberoptic-endoscopic-exam-of-the-swallow-procedure
#19
Susan L Brady, Noel Rao, Patricia J Gibbons, Letha Williams, Mark Hakel, Theresa Pape
Objective: The aim of this study was to evaluate the comparative effectiveness of an online, interdisciplinary, interactive course designed to increase the ability to accurately interpret the fiberoptic endoscopic exam of the swallow (FEES) procedure to traditional, face-to-face (F2F) lectures for both graduate medical education (GME) and graduate speech language pathology (GSLP) programs. Design: This was a prospective, quantitative, nonrandomized study. Participants were medical residents in physical medicine and rehabilitation from two affiliated programs and graduate students in speech language pathology from two instructional cohorts at a single institution...
2018: Advances in Medical Education and Practice
https://www.readbyqxmd.com/read/29927994/in-silico-characterisation-of-the-two-component-system-regulators-of-streptococcus-pyogenes
#20
Sean J Buckley, Peter Timms, Mark R Davies, David J McMillan
Bacteria respond to environmental changes through the co-ordinated regulation of gene expression, often mediated by two-component regulatory systems (TCS). Group A Streptococcus (GAS), a bacterium which infects multiple human body sites and causes multiple diseases, possesses up to 14 TCS. In this study we examined genetic variation in the coding sequences and non-coding DNA upstream of these TCS as a method for evaluating relationships between different GAS emm-types, and potential associations with GAS disease...
2018: PloS One
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