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https://www.readbyqxmd.com/read/28647722/developing-implementation-strategies-for-firearm-safety-promotion-in-paediatric-primary-care-for-suicide-prevention-in-two-large-us-health-systems-a-study-protocol-for-a-mixed-methods-implementation-study
#1
Courtney Benjamin Wolk, Shari Jager-Hyman, Steven C Marcus, Brian K Ahmedani, John E Zeber, Joel A Fein, Gregory K Brown, Adina Lieberman, Rinad S Beidas
INTRODUCTION: The promotion of safe firearm practices, or firearms means restriction, is a promising but infrequently used suicide prevention strategy in the USA. Safety Check is an evidence-based practice for improving parental firearm safety behaviour in paediatric primary care. However, providers rarely discuss firearm safety during visits, suggesting the need to better understand barriers and facilitators to promoting this approach. This study, Adolescent Suicide Prevention In Routine clinical Encounters, aims to engender a better understanding of how to implement the three firearm components of Safety Check as a suicide prevention strategy in paediatric primary care...
June 24, 2017: BMJ Open
https://www.readbyqxmd.com/read/28646260/salt-appetite-and-the-influence-of-opioids
#2
Craig M Smith, Andrew J Lawrence
Due to the biological importance of sodium and its relative scarcity within many natural environments, 'salt appetite' has evolved whereby dietary salt is highly sought after and palatable when tasted. In addition to peripheral responses, salt depletion is detected within the brain via circumventricular organs and 11β-hydroxysteroid dehydrogenase type 2 (HSD2) neurons to increase salt appetite. Salt appetite is comprised of two main components. One component is the incentive salience or motivation for salt (i...
June 24, 2017: Neurochemical Research
https://www.readbyqxmd.com/read/28645947/role-structure-and-effects-of-medical-tourism-in-africa-a-systematic-scoping-review-protocol
#3
John Jo Mogaka, Joyce M Tsoka-Gwegweni, Lucia M Mupara, Tivani Mashamba-Thompson
INTRODUCTION: Some patients travel out of, while others come into Africa for medical care through a growing global phenomenon referred to as medical tourism (MT): the travel in search of medical care that is either unavailable, unaffordable or proscribed at home healthcare systems. While some castigate MT as promoting healthcare inequity, others endorse it as a revenue generator, promising local healthcare system strengthening. Currently, however, the understanding of this component of healthcare in Africa is inadequate...
June 23, 2017: BMJ Open
https://www.readbyqxmd.com/read/28645898/dna-pk-facilitates-piggybac-transposition-by-promoting-paired-end-complex-formation
#4
Yan Jin, Yaohui Chen, Shimin Zhao, Kun-Liang Guan, Yuan Zhuang, Wenhao Zhou, Xiaohui Wu, Tian Xu
The involvement of host factors is critical to our understanding of underlying mechanisms of transposition and the applications of transposon-based technologies. Modified piggyBac (PB) is one of the most potent transposon systems in mammals. However, varying transposition efficiencies of PB among different cell lines have restricted its application. We discovered that the DNA-PK complex facilitates PB transposition by binding to PB transposase (PBase) and promoting paired-end complex formation. Mass spectrometry analysis and coimmunoprecipitation revealed physical interaction between PBase and the DNA-PK components Ku70, Ku80, and DNA-PKcs Overexpression or knockdown of DNA-PK components enhances or suppresses PB transposition in tissue culture cells, respectively...
June 23, 2017: Proceedings of the National Academy of Sciences of the United States of America
https://www.readbyqxmd.com/read/28645603/robotic-transnasal-endoscopic-skull-base-surgery-systematic-review-of-the-literature-and-report-of-a-novel-prototype-for-a-hybrid-system-bear
#5
Andrea Bolzoni Villaret, Francesco Doglietto, Andrea Carobbio, Alberto Schreiber, Camilla Panni, Enrico Piantoni, Giovanni Guida, Marco Maria Fontanella, Piero Nicolai, Riccardo Cassinis
BACKGROUND: Although robotics has already been applied to several surgical fields, available systems are not designed for endoscopic skull base surgery (ESBS). New-conception prototypes have been recently described for ESBS. AIM OF THE STUDY: To provide a systematic literature review of robotics for ESBS and describe a novel prototype developed at the University of Brescia. MATERIAL AND METHODS: PubMed and Scopus databases were searched using a combination of terms, including Robotics OR Robot and Surgery OR Otolaryngology OR Skull Base OR Holder...
June 20, 2017: World Neurosurgery
https://www.readbyqxmd.com/read/28645081/loudness-and-time-dependence-of-auditory-evoked-potentials-is-blunted-by-the-nmda-channel-blocker-mk-801
#6
Tobias Teichert
Amplitudes of auditory evoked potentials (AEP) increase with the intensity/loudness of sounds (loudness-dependence of AEP, LDAEP), and the time between adjacent sounds (time-dependence of AEP, TDAEP). Both, blunted LDAEP and blunted TDAEP are markers of altered auditory function in schizophrenia (SZ). However, while blunted LDAEP has been attributed to altered serotonergic function, blunted TDAEP has been linked to altered NMDA receptor function. Despite phenomenological similarities of the two effects, no common pharmacological underpinnings have been identified...
June 15, 2017: Psychiatry Research
https://www.readbyqxmd.com/read/28645052/cardiorespiratory-responses-of-air-filtration-a-randomized-crossover-intervention-trial-in-seniors-living-in-beijing-beijing-indoor-air-purifier-study-biapsy
#7
Danqing Shao, Yipeng Du, Shuo Liu, Bert Brunekreef, Kees Meliefste, Qian Zhao, Jie Chen, Xiaoming Song, Meng Wang, Juan Wang, Hongbing Xu, Rongshan Wu, Tong Wang, Baihuan Feng, Candice Shih-Chun Lung, Xian Wang, Bei He, Wei Huang
In this Beijing Indoor Air Purifier StudY (BIAPSY), we conducted a randomized crossover intervention trial in a panel of 35 non-smoking senior participants with free-living, with and without chronic obstructive pulmonary disease (COPD). Portable air filtration units were randomly allocated to active-(filter in) for 2weeks and sham-mode (filter out) for 2weeks in the households. We examined the differences in indoor air pollutant concentrations in 20 study homes and a suite of cardio-respiratory biomarker levels in study participants between filtration modes, with and without adjustment for potential confounders...
June 20, 2017: Science of the Total Environment
https://www.readbyqxmd.com/read/28644475/post-translational-modification-of-ribosomally-synthesized-peptides-by-a-radical-sam-epimerase-in-bacillus-subtilis
#8
Alhosna Benjdia, Alain Guillot, Pauline Ruffié, Jérôme Leprince, Olivier Berteau
Ribosomally synthesized peptides are built out of L-amino acids, whereas D-amino acids are generally the hallmark of non-ribosomal synthetic processes. Here we show that the model bacterium Bacillus subtilis is able to produce a novel type of ribosomally synthesized and post-translationally modified peptide that contains D-amino acids, and which we propose to call epipeptides. We demonstrate that a two [4Fe-4S]-cluster radical S-adenosyl-L-methionine (SAM) enzyme converts L-amino acids into their D-counterparts by catalysing Cα-hydrogen-atom abstraction and using a critical cysteine residue as the hydrogen-atom donor...
July 2017: Nature Chemistry
https://www.readbyqxmd.com/read/28644392/development-of-bone-targeting-drugs
#9
REVIEW
Molly Stapleton, Kazuki Sawamoto, Carlos J Alméciga-Díaz, William G Mackenzie, Robert W Mason, Tadao Orii, Shunji Tomatsu
The skeletal system, comprising bones, ligaments, cartilage and their connective tissues, is critical for the structure and support of the body. Diseases that affect the skeletal system can be difficult to treat, mainly because of the avascular cartilage region. Targeting drugs to the site of action can not only increase efficacy but also reduce toxicity. Bone-targeting drugs are designed with either of two general targeting moieties, aimed at the entire skeletal system or a specific cell type. Most bone-targeting drugs utilize an affinity to hydroxyapatite, a major component of the bone matrix that includes a high concentration of positively-charged Ca(2+)...
June 23, 2017: International Journal of Molecular Sciences
https://www.readbyqxmd.com/read/28643832/metasurface-integrated-high-energy-efficient-and-high-linearly-polarized-ingan-gan-light-emitting-diode
#10
Miao Wang, Fuyang Xu, Yu Lin, Bing Cao, Linghua Chen, Chinhua Wang, Jianfeng Wang, Ke Xu
We proposed and demonstrated an integrated high energy efficient and high linearly polarized InGaN/GaN green LED grown on (0001) oriented sapphire with combined metasurface polarizing converter and polarizer system. It is different from those conventional polarized light emissions generated with plasmonic metallic grating in which at least 50% high energy loss occurs inherently due to high reflection of the transverse electric (TE) component of an electric field. A reflecting metasurface, with a two dimensional elliptic metal cylinder array (EMCA) that functions as a half-wave plate, was integrated at the bottom of a LED such that the back-reflected TE component, that is otherwise lost by a dielectric/metal bi-layered wire grids (DMBiWG) polarizer on the top emitting surface of the LED, can be converted to desired transverse magnetic (TM) polarized emission after reflecting from the metasurface...
June 23, 2017: Nanoscale
https://www.readbyqxmd.com/read/28641419/thermodynamic-formulation-of-the-barrier-for-heterogeneous-pinned-nucleation-implication-to-the-crossover-scenarios-associated-with-barrierless-and-homogeneous-nucleation
#11
Sanat K Singha, Prasanta K Das, Biswajit Maiti
The effect of contact line pinning on nucleation is reported using continuum thermodynamics. Based on the principle of the free-energy maximization, closed-form expressions in the dimensionless form for the free-energy of the three-phase metastable system and the thermodynamic barrier are formulated with respect to the system geometry and the substrate wettability. The condition of maximality limits the dynamic contact angle within the cluster-phase-phobic regime. The dimensionless nucleation barrier or the potency factor can be divided into two components related to the system geometry and the pinning effect...
June 21, 2017: Journal of Chemical Physics
https://www.readbyqxmd.com/read/28640260/microscopy-of-the-interacting-harper-hofstadter-model-in-the-two-body-limit
#12
M Eric Tai, Alexander Lukin, Matthew Rispoli, Robert Schittko, Tim Menke, Dan Borgnia, Philipp M Preiss, Fabian Grusdt, Adam M Kaufman, Markus Greiner
The interplay between magnetic fields and interacting particles can lead to exotic phases of matter that exhibit topological order and high degrees of spatial entanglement. Although these phases were discovered in a solid-state setting, recent innovations in systems of ultracold neutral atoms-uncharged atoms that do not naturally experience a Lorentz force-allow the synthesis of artificial magnetic, or gauge, fields. This experimental platform holds promise for exploring exotic physics in fractional quantum Hall systems, owing to the microscopic control and precision that is achievable in cold-atom systems...
June 21, 2017: Nature
https://www.readbyqxmd.com/read/28639716/expression-of-the-autoantigen-trim33-tif1%C3%AE-in-skin-and-muscle-of-patients-with-dermatomyositis-is-upregulated-together-with-markers-of-cellular-stress
#13
B Scholtissek, S Ferring-Schmitt, J Maier, J Wenzel
Dermatomyositis (DM) is an autoimmune disorder associated with a dysregulation of immune homeostasis of both the innate and adaptive immune system. Earlier data suggested that these two arms of the immune system interconnect in DM. In the current study, we analysed the association of autoantigen expression [adaptive system components: Mi2, transcriptional intermediary factor (TIF)1γ, small ubiquitin-like modifier 1 activating enzyme subunit (SAE)1, melanoma differentiation-associated protein (MDA)5] with markers of cellular stress (innate system components: MxA, p53) in skin and muscle (immunohistology and gene expression data, respectively)...
June 22, 2017: Clinical and Experimental Dermatology
https://www.readbyqxmd.com/read/28638001/comparison-between-glioblastoma-and-primary-central-nervous-system-lymphoma-using-mr-image-based-texture-analysis
#14
Akira Kunimatsu, Natsuko Kunimatsu, Kouhei Kamiya, Takeyuki Watadani, Harushi Mori, Osamu Abe
PURPOSE: To elucidate differences between glioblastoma (GBM) and primary central nervous system lymphoma (PCNSL) with magnetic resonance (MR) image-based texture features. METHODS: This was an Institutional Review Board (IRB)-approved retrospective study. Consecutive, pathologically proven, initially treated 44 patients with GBM and 16 patients with PCNSL were enrolled. We calculated a total of 67 image texture features on the largest contrast-enhancing lesion in each patient on post-contrast T1-weighted images...
June 22, 2017: Magnetic Resonance in Medical Sciences: MRMS
https://www.readbyqxmd.com/read/28636786/exacta-the-complement-system-in-kidney-diseases
#15
S Reuter, R Mrowka
The complement system, a plasma component, was described upon its discovery to augment the opsonisation of bacteria by antibodies, 'complementing' said antibodies' antibacterial activity. In its first and foremost role, the complement cascade helps convert pathogen recognition into an effective host defence. Two recent publications in Acta Physiologica have highlighted the role of complement factors in immune cell function, namely monoamine transmitter release from immune cells during immune response and inflammation(1, 2) This article is protected by copyright...
June 21, 2017: Acta Physiologica
https://www.readbyqxmd.com/read/28636366/oxygenation-via-c-h-c-c-bond-activation-with-molecular-oxygen
#16
Yu-Feng Liang, Ning Jiao
The selective oxidation of organic molecules is a fundamentally important component of modern synthetic chemistry. In the past decades, direct oxidative C-H and C-C bond functionalization has proved to be one of the most efficient and straightforward methods to synthesize complex products from simple and readily available starting materials. Among these oxidative processes, the use of molecular oxygen as a green and sustainable oxidant has attracted considerable attention because of its highly atom-economical, abundant, and environmentally friendly characteristics...
June 21, 2017: Accounts of Chemical Research
https://www.readbyqxmd.com/read/28636350/integrating-a-semi-transparent-fullerene-free-organic-solar-cell-in-tandem-with-a-bivo4-photoanode-for-unassisted-solar-water-splitting
#17
Yuelin Peng, Gokul V Govindaraju, Dong Ki Lee, Kyoung-Shin Choi, Trisha L Andrew
We report an unassisted solar water splitting system powered by a diketopyrrolopyrrole (DPP)-containing semi-transparent organic solar cell. Two major merits of this fullerene-free solar cell enable its integration with a BiVO4 photoanode. First is the high open circuit voltage and high fill factor displayed by this single junction solar cell, which yields sufficient power to effect water splitting when serially-connected to an appropriate electrode/catalyst. Second, the wavelength-resolved photoaction spectrum of the DPP-based solar cell has minimal overlap with that of the BiVO4 photoanode, thus ensuring that light collection across these two components can be optimized...
June 21, 2017: ACS Applied Materials & Interfaces
https://www.readbyqxmd.com/read/28635956/self-assembled-three-dimensional-network-designs-for-soft-electronics
#18
Kyung-In Jang, Kan Li, Ha Uk Chung, Sheng Xu, Han Na Jung, Yiyuan Yang, Jean Won Kwak, Han Hee Jung, Juwon Song, Ce Yang, Ao Wang, Zhuangjian Liu, Jong Yoon Lee, Bong Hoon Kim, Jae-Hwan Kim, Jungyup Lee, Yongjoon Yu, Bum Jun Kim, Hokyung Jang, Ki Jun Yu, Jeonghyun Kim, Jung Woo Lee, Jae-Woong Jeong, Young Min Song, Yonggang Huang, Yihui Zhang, John A Rogers
Low modulus, compliant systems of sensors, circuits and radios designed to intimately interface with the soft tissues of the human body are of growing interest, due to their emerging applications in continuous, clinical-quality health monitors and advanced, bioelectronic therapeutics. Although recent research establishes various materials and mechanics concepts for such technologies, all existing approaches involve simple, two-dimensional (2D) layouts in the constituent micro-components and interconnects. Here we introduce concepts in three-dimensional (3D) architectures that bypass important engineering constraints and performance limitations set by traditional, 2D designs...
June 21, 2017: Nature Communications
https://www.readbyqxmd.com/read/28635503/practical-guidelines-to-minimise-language-and-cognitive-confounds-in-the-diagnosis-of-capd-a-brief-tutorial
#19
Gail D Chermak, Doris-Eva Bamiou, Vasiliki Vivian Iliadou, Frank E Musiek
OBJECTIVE: To provide audiologists with strategies to minimise confounding cognitive and language processing variables and accurately diagnose central auditory processing disorder (CAPD). DESIGN: Tutorial. STUDY SAMPLE: None. RESULTS: Strategies are reviewed to minimise confounding cognitive and language processing variables and accurately diagnose CAPD. CONCLUSIONS: Differential diagnosis is exceedingly important and can be quite challenging...
February 28, 2017: International Journal of Audiology
https://www.readbyqxmd.com/read/28634902/therapeutic-potential-of-baicalein-in-alzheimer-s-disease-and-parkinson-s-disease
#20
Yanwei Li, Jinying Zhao, Christian Hölscher
Alzheimer's disease and Parkinson's disease are the two most common, progressive central neurodegenerative diseases affecting the population over the age of 60 years. Apart from treatments that temporarily improve symptoms, there is no medicine currently available to inhibit or reverse the progression of Alzheimer's disease and Parkinson's disease. In traditional Chinese medicine, the root of Scutellaria baicalensis Georgi is a classic compatible component in the decoction of herbal medicine used for treating central nervous system diseases...
June 20, 2017: CNS Drugs
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