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https://www.readbyqxmd.com/read/29684450/simultaneous-adsorption-of-cu-2-and-acid-fuchsin-af-from-aqueous-solutions-by-cmc-bentonite-composite
#1
Ning Gong, Yanping Liu, Ruihua Huang
Carboxymethyl-chitosan (CMC)/bentonite composite was prepared by the method of membrane-forming, and characterized by Fourier transform infrared spectroscopy (FTIR) and X-ray diffraction (XRD) techniques. The simultaneous adsorption of Cu2+ and Acid fuchsin (AF) applying CMC/bentonite composite as an adsorbent in single or binary systems was investigated. The adsorption study was conducted systematically by varying the ratio of CMC to bentonite, adsorbent dosage, initial pH value, initial Cu2+ (or AF) concentration, contact time and the interaction of two components in binary solutions...
April 20, 2018: International Journal of Biological Macromolecules
https://www.readbyqxmd.com/read/29684072/arginine-is-a-component-of-the-ammonium-cyg56-signalling-cascade-that-represses-genes-of-the-nitrogen-assimilation-pathway-in-chlamydomonas-reinhardtii
#2
David González-Ballester, Emanuel Sanz-Luque, Aurora Galván, Emilio Fernández, Amaury de Montaigu
Nitrogen assimilation and metabolism are essential processes for all living organisms, yet there is still much to be learnt on how they are regulated. The use of Chlamydomonas reinhardtii as a model system has been instrumental not only in identifying conserved regulation mechanisms that control the nitrogen assimilation pathway, but also in understanding how the intracellular nitrogen status regulates metabolic processes of industrial interest such as the synthesis of biolipids. While the genetic regulators that control the nitrogen pathway are successfully being unravelled, other layers of regulation have received less attention...
2018: PloS One
https://www.readbyqxmd.com/read/29682837/massive-transfusion-changing-practice-in-a-single-norwegian-centre-2002-2015
#3
H Doughty, T O Apelseth, J Sivertsen, K Annaniasen, T Hervig
OBJECTIVES: To describe the change in massive transfusion (MT) practice in a single Norwegian centre throughout the period 2002-2015. BACKGROUND: MT support for traumatic haemorrhage has changed since the mid-2000s. However, life-threatening haemorrhage may occur in other clinical specialties. In 2007, Haukeland University Hospital (HUS) introduced a universal MT programme including education, Acute Transfusion Packages (ATPs) and thromboelastography. METHODS/MATERIALS: A retrospective review was performed of all MT episodes defined as ≥10 red cell concentrates (RCC) in 24 h...
April 23, 2018: Transfusion Medicine
https://www.readbyqxmd.com/read/29682701/selective-effects-of-5-ht2c-receptor-modulation-on-performance-of-a-novel-valence-probe-visual-discrimination-task-and-probabilistic-reversal-learning-in-mice
#4
Benjamin U Phillips, Sigma Dewan, Simon R O Nilsson, Trevor W Robbins, Christopher J Heath, Lisa M Saksida, Timothy J Bussey, Johan Alsiö
RATIONALE: Dysregulation of the serotonin (5-HT) system is a pathophysiological component in major depressive disorder (MDD), a condition closely associated with abnormal emotional responsivity to positive and negative feedback. However, the precise mechanism through which 5-HT tone biases feedback responsivity remains unclear. 5-HT2C receptors (5-HT2CRs) are closely linked with aspects of depressive symptomatology, including abnormalities in reinforcement processes and response to stress...
April 22, 2018: Psychopharmacology
https://www.readbyqxmd.com/read/29682545/curcumin-as-a-promising-antibacterial-agent-effects-on-metabolism-and-biofilm-formation-in-s-mutans
#5
Bingchun Li, Xinlong Li, Huancai Lin, Yan Zhou
Streptococcus mutans (S. mutans) has been proved to be the main aetiological factor in dental caries. Curcumin, a natural product, has been shown to exhibit therapeutic antibacterial activity, suggesting that curcumin may be of clinical interest. The objective of this study is to evaluate the inhibitory effects of curcumin on metabolism and biofilm formation in S. mutans using a vitro biofilm model in an artificial oral environment. S. mutans biofilms were treated with varying concentrations of curcumin. The biofilm metabolism and biofilm biomass were assessed by the 3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyl tetrazolium bromide assay and the crystal violet assay...
2018: BioMed Research International
https://www.readbyqxmd.com/read/29681809/tactile-star-a-novel-tactile-stimulator-and-recorder-system-for-evaluating-and-improving-tactile-perception
#6
Giulia Ballardini, Giorgio Carlini, Psiche Giannoni, Robert A Scheidt, Ilana Nisky, Maura Casadio
Many neurological diseases impair the motor and somatosensory systems. While several different technologies are used in clinical practice to assess and improve motor functions, somatosensation is evaluated subjectively with qualitative clinical scales. Treatment of somatosensory deficits has received limited attention. To bridge the gap between the assessment and training of motor vs. somatosensory abilities, we designed, developed, and tested a novel, low-cost, two-component (bimanual) mechatronic system targeting tactile somatosensation: the Tactile-STAR -a tactile stimulator and recorder...
2018: Frontiers in Neurorobotics
https://www.readbyqxmd.com/read/29681798/the-lili-motif-of-m3-s2-linkers-is-a-component-of-the-nmda-receptor-channel-gate
#7
Marek Ladislav, Jiri Cerny, Jan Krusek, Martin Horak, Ales Balik, Ladislav Vyklicky
N-methyl-D-aspartate receptors (NMDARs) mediate excitatory synaptic transmission in the central nervous system, underlie the induction of synaptic plasticity, and their malfunction is associated with human diseases. Native NMDARs are tetramers composed of two obligatory GluN1 subunits and various combinations of GluN2A-D or, more rarely, GluN3A-B subunits. Each subunit consists of an amino-terminal, ligand-binding, transmembrane and carboxyl-terminal domain. The ligand-binding and transmembrane domains are interconnected via polypeptide chains (linkers)...
2018: Frontiers in Molecular Neuroscience
https://www.readbyqxmd.com/read/29680123/twenty-five-years-of-investigating-the-universal-stress-protein-function-structure-and-applications
#8
Amy C Vollmer, Steven J Bark
Since the initial discovery of universal stress protein A (UspA) 25 years ago, remarkable advances in molecular and biochemical technologies have revolutionized our understanding of biology. Many studies using these technologies have focused on characterization of the uspA gene and Usp-type proteins. These studies have identified the conservation of Usp-like proteins across bacteria, archaea, plants, and even some invertebrate animals. Regulation of these proteins under diverse stresses has been associated with different stress-response genes including spoT and relA in the stringent response and the dosR two-component signaling pathways...
2018: Advances in Applied Microbiology
https://www.readbyqxmd.com/read/29679462/impact-of-urbanization-on-abundance-and-phenology-of-caterpillars-and-consequences-for-breeding-in-an-insectivorous-bird
#9
Gábor Seress, Tamás Hammer, Veronika Bókony, Ernő Vincze, Bálint Preiszner, Ivett Pipoly, Csenge Sinkovics, Karl L Evans, András Liker
Urbanization can have marked effects on plant and animal populations' phenology, population size, predator-prey interactions and reproductive success. These aspects are rarely studied simultaneously in a single system, and some are rarely investigated, e.g. how insect phenology responds to urban development. Here, we study a tri-trophic system of trees - phytophagous insects (caterpillars) - insectivorous birds (great tits) to assess how urbanization influences i) the phenology of each component of this system, ii) insect abundance and iii) avian reproductive success...
April 20, 2018: Ecological Applications: a Publication of the Ecological Society of America
https://www.readbyqxmd.com/read/29678958/cholesterol-and-the-journey-of-extracellular-vesicles
#10
Frank W Pfrieger, Nicolas Vitale
Eukaryotic cells employ distinct means to release specific signals and material. Research within the last decade has identified different types of membrane-enclosed structures collectively called extracellular vesicles (EVs) as one of them. EVs fall in two categories depending on their subcellular origin. Exosomes are generated within the endosomal system and reach the extracellular space upon fusion of multivesicular bodies (MVBs). Microvesicles or microparticles are generated by shedding of the plasma membrane...
April 20, 2018: Journal of Lipid Research
https://www.readbyqxmd.com/read/29678449/using-primary-organotypic-mouse-midbrain-cultures-to-examine-developmental-neurotoxicity-of-silver-nanoparticles-across-two-genetic-strains
#11
Brittany A Weldon, Julie Juyoung Park, Sungwoo Hong, Tomomi Workman, Russell Dills, Ji Hyun Lee, William C Griffith, Terrance J Kavanagh, Elaine M Faustman
Micromass culture systems have been developed as three-dimensional organotypic in vitro alternatives to test developmental toxicity. We have optimized a murine-based embryonic midbrain micromass system in two genetic strains to evaluate neurodevelopmental effects of gold-cored silver nanoparticles (AgNPs) of differing sizes and coatings-20 nm AgCitrate, 110 nm AgCitrate, and 110 nm AgPVP. AgNPs are increasingly used in consumer, commercial, and medical products for their antimicrobial properties and observations of Ag in adult and fetal brain following in vivo exposures to AgNPs have led to concerns about the potential for AgNPs to elicit adverse effects on neurodevelopment and neurological function...
April 17, 2018: Toxicology and Applied Pharmacology
https://www.readbyqxmd.com/read/29677833/convenient-colorimetric-detection-of-cholesterol-using-multi-enzyme-co-incorporated-organic-inorganic-hybrid-nanoflowers
#12
Minsoo Chung, Yoon Jung Jang, Moon Il Kim
We have developed a microscale well-plate colorimetric assay for the multiplexed detection of cholesterol in clinical human blood samples. This system utilizes a novel multi-enzyme incorporated organic-inorganic hybrid nanoflower which entrap both cholesterol oxidase (ChOx) and horseradish peroxidase (HRP) as the organic components with copper phosphate as the inorganic component to detect cholesterol levels in blood samples. The hybrid nanoflowers, synthesized via an extremely simple but rapid sonication-mediated method within 5 min at room temperature, enable an efficient one-pot two-enzyme cascade reaction...
September 1, 2018: Journal of Nanoscience and Nanotechnology
https://www.readbyqxmd.com/read/29677669/toxicological-interaction-of-multi-component-mixtures-to-vibrio-qinghaiensis-sp-q67-induced-by-at-least-three-components
#13
Ya-Qian Xu, Shu-Shen Liu, Ye Fan, Kai Li
It has been stated by researchers that the antibiotic polymyxin B sulfate (POL) is a key component inducing time-dependent antagonism in freshwater luminescent bacteria, Vibrio qinghaiensis sp.-Q67, exposed in the ternary mixture system of the ionic liquids, pesticide and antibiotics. However, the previous statement is limited to ternary and quaternary mixtures without considering situations such as the binary system. In order to prove the direct inducing of antagonism by POL in a more complete and systematic way, two categories of experiments (adding POL in non-antagonistic ternary system and decomposing antagonistic ternary system with POL into the binary system) have been conducted in this paper...
April 17, 2018: Science of the Total Environment
https://www.readbyqxmd.com/read/29677477/systems-immunology-learning-the-rules-of-the-immune-system
#14
Alexandra-Chloé Villani, Siranush Sarkizova, Nir Hacohen
Given the many cell types and molecular components of the human immune system, along with vast variations across individuals, how should we go about developing causal and predictive explanations of immunity? A central strategy in human studies is to leverage natural variation to find relationships among variables, including DNA variants, epigenetic states, immune phenotypes, clinical descriptors, and others. Here, we focus on how natural variation is used to find patterns, infer principles, and develop predictive models for two areas: (a) immune cell activation-how single-cell profiling boosts our ability to discover immune cell types and states-and (b) antigen presentation and recognition-how models can be generated to predict presentation of antigens on MHC molecules and their detection by T cell receptors...
April 26, 2018: Annual Review of Immunology
https://www.readbyqxmd.com/read/29676283/a-combined-positron-emission-tomography-pet-electron-paramagnetic-resonance-imaging-epri-system-initial-evaluation-of-a-prototype-scanner
#15
Mark Tseytlin, Alexander V Stolin, Priyaankadevi Guggilapu, Andrey A Bobko, Valery V Khramtsov, Oxana Tseytlin, Raymond R Raylman
The advent of hybrid scanners, combining complementary modalities, has revolutionized imaging; enhancing clinical practice and biomedical research. In this project, we investigated the melding of two complementary, functional imaging methods: positron emission tomography (PET) and electron paramagnetic resonance imaging (EPRI). The PET radiotracers can provide important information about cellular parameters, such as glucose metabolism. While EPR probes can provide assessment of tissue microenvironment, measuring parameters such as oxygenation and pH, for example...
April 20, 2018: Physics in Medicine and Biology
https://www.readbyqxmd.com/read/29675601/asymptotic-analysis-of-a-tmdd-model-when-a-reaction-contributes-to-the-destruction-of-its-product
#16
Lida I Michalaki, Dimitris A Goussis
The multi-scale dynamics of a two-compartment with first order absorption Target-Mediated Drug Disposition (TMDD) pharmacokinetics model is analysed, using the Computational Singular Perturbation (CSP) algorithm. It is shown that the process evolves along two Slow Invariant Manifolds (SIMs), on which the most intense components of the model are equilibrated, so that the less intensive are the driving ones. The CSP tools allow for the identification of the components of the TMDD model that (i) constrain the evolution of the process on the SIMs, (ii) drive the system along the SIMs and (iii) generate the fast time scales...
April 19, 2018: Journal of Mathematical Biology
https://www.readbyqxmd.com/read/29675194/exploring-the-role-of-ionic-liquids-to-tune-the-polymorphic-outcome-of-organic-compounds
#17
Qingying Zeng, Arijit Mukherjee, Peter Müller, Robin D Rogers, Allan S Myerson
While molecular solvents are commonly used in the screening of polymorphs, the choices are often restricted. Ionic liquids (ILs) - also referred as designer solvents - have immense possibility in this regard because of their wide flexibility of tunability. More importantly, the interactions among the IL components are completely unique compared to those present in the molecular solvents. In this context, we have chosen tetrolic acid (TA) and isonicotinamide (INA), which showed solution-structure link in molecular solvents in the past, as probes to investigate the role of imidazolium based ionic liquids in the polymorphism of these two systems and whether the different solute-solvent interactions in ILs affect the polymorphic outcome...
February 14, 2018: Chemical Science
https://www.readbyqxmd.com/read/29675027/photosynthetic-performance-and-vegetative-growth-in-a-new-red-leaf-pear-comparison-of-scion-genotypes-using-a-complex-grafted-plant-system
#18
Francesca Tozzi, Ben M van Hooijdonk, Donald S Tustin, Luca Corelli Grappadelli, Brunella Morandi, Pasquale Losciale, Luigi Manfrini
Leaf photosynthetic performance of a new red-skinned inter-specific hybrid pear variety called 'PremP009' (PIQA®BOO®) is presently unknown and therefore was compared to the Asian pear variety 'Hosui'. The seasonal growth patterns and the final dry matter accumulation of all tree components were also investigated for both genotypes in their first year of growth after grafting. Leaf gas exchange and tree growth comparisons were assessed using an innovative grafted plant system, which involved a bi-axis tree with the presence of combinations of identical or mixed (one of each genotype) 'PremP009' and 'Hosui' scion genotypes grafted onto a single clonal rootstock ('Buerre Hardy' BA29)...
2018: Frontiers in Plant Science
https://www.readbyqxmd.com/read/29674028/a-novel-surface-enhanced-raman-scattering-sers-detection-for-natural-gas-exploration-using-methane-oxidizing-bacteria
#19
Weiwei Liang, Qiao Chen, Fang Peng, Aiguo Shen, Jiming Hu
Methane-oxidizing bacteria (MOB), a unique group of Gram-negative bacteria utilizing methane as a sole source of carbon and energy, have been proved to be a biological indicator for gas prospecting. Field and cultivation-free detection of MOB is important but still challenging in current microbial prospecting of oil and gas (MPOG) system. Herein, SERS was used for the first time to our knowledge to investigate two species of methanotrophs and four closely relevant bacteria that universally coexisted in the upper soil of natural gas...
July 1, 2018: Talanta
https://www.readbyqxmd.com/read/29673620/effects-of-opioid-and-non-opioid-analgesics-on-responses-to-psychosocial-stress-in-humans
#20
Anya K Bershad, Melissa A Miller, Greg J Norman, Harriet de Wit
Both preclinical and clinical evidence suggests that the endogenous opioid system is involved in responses to stress. For example, in animal models opioid agonists reduce isolation distress whereas opioid antagonists increase isolation distress. We recently reported that the mixed mu agonist and kappa antagonist buprenorphine dampened responses to acute psychosocial stress in humans. Now we extend this to study the effects of a pure mu-opioid agonist, hydromorphone, and a non-opioid analgesic, acetaminophen, on response to social stress...
April 16, 2018: Hormones and Behavior
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