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https://www.readbyqxmd.com/read/29217489/fixed-volume-particle-trace-emission-for-the-analysis-of-left-atrial-blood-flow-using-4d-flow-mri
#1
Stephen Gaeta, Petter Dyverfeldt, Jonatan Eriksson, Carl-Johan Carlhäll, Tino Ebbers, Ann F Bolger
4D Flow MRI has been used to quantify normal and deranged left ventricular blood flow characteristics on the basis of functionally distinct flow components. However, the application of this technique to the atria is challenging due to the presence of continuous inflow. This continuous inflow necessitates plane-based emission of particle traces from the inlet veins, leading to particles that represents different amounts of blood, and related quantification errors. The purpose of this study was to develop a novel fixed-volume approach for particle tracing and employ this method to develop quantitative analysis of 4D blood flow characteristics in the left atrium...
December 4, 2017: Magnetic Resonance Imaging
https://www.readbyqxmd.com/read/29216924/dengue-hemorrhagic-fever-complicated-with-acute-liver-failure-a-case-report
#2
Chamara Dalugama, Indika Bandara Gawarammana
BACKGROUND: Dengue is a common arboviral infection with a clinically diverse spectrum of presentations. Although hepatic dysfunction is commonly identified in patients will dengue illness, acute liver failure is rare. The etiopathogenesis of hepatic dysfunction is multifactorial and related to direct viral invasion of hepatocytes, immunological factors and hypoxia particularly in cases of shock in dengue hemorrhagic fever. Ideal management of dengue-related hepatic dysfunction and acute liver failure is still debated...
December 8, 2017: Journal of Medical Case Reports
https://www.readbyqxmd.com/read/29211784/urinary-metabolomic-analysis-to-identify-preterm-neonates-exposed-to-histological-chorioamnionitis-a-pilot-study
#3
Claudia Fattuoni, Carlo Pietrasanta, Lorenza Pugni, Andrea Ronchi, Francesco Palmas, Luigi Barberini, Angelica Dessì, Roberta Pintus, Vassilios Fanos, Antonio Noto, Fabio Mosca
OBJECTIVE: Chorioamnionitis is a leading cause of preterm birth worldwide, with higher incidence at lower gestational ages. An early and reliable diagnosis of histological chorioamnionitis (HCA) in preterm infants may be helpful in guiding postnatal management, especially the administration of prophylactic antibiotics to prevent early-onset sepsis. The main aim of this study was to investigate metabolomic analysis of urines collected in the first 24 hours of life as diagnostic tool of HCA...
2017: PloS One
https://www.readbyqxmd.com/read/29210661/impact-of-different-antiretroviral-strategies-on-total-hiv-dna-level-in-virologically-suppressed-hiv-1-infected-patients
#4
Isabella Bon, Leonardo Calza, Giuseppina Musumeci, Serena Longo, Alessia Bertoldi, Vanessa D'Urbano, Davide Gibellini, Eleonora Magistrelli, Pier Luigi Viale, Maria Carla Re
Background Total HIV-DNA load in peripheral blood cell (PBMCs) reflects the global viral reservoir that seems to be not affect by antiretroviral treatment. However, some studies reported a different permeability of different drugs in cellular compartments. Objective To investigate the relation between the amount of total HIV-1 DNA and different treatment strategies. Method Total HIV-1 DNA was quantified by real time PCR in PBMCs collected from 161 patients with long-term undetectable HIV-RNA receiving different therapy schedules (3-drug regimens or 2-drug regimen containing Raltegravir as integrase inhibitor)...
December 6, 2017: Current HIV Research
https://www.readbyqxmd.com/read/29210119/diets-rich-in-saturated-fat-and-fructose-induce-anxiety-and-depression-like-behaviours-in-the-rat-is-there-a-role-for-lipid-peroxidation
#5
Silvia Gancheva, Bistra Galunska, Maria Zhelyazkova-Savova
Epidemiological studies reveal associations between obesity/metabolic syndrome and mood disorders. We assessed behavioural changes in rats fed diets enriched in fat and fructose in different proportions and correlated the observed alterations with biochemical changes induced by the diets. Three groups of rats were used as follows: control (C) animals fed regular rat chow, rats fed high-fat diet (HF) and rats fed high-fat and high-fructose diet (HFHF). HF and HFHF animals were also given a 10% fructose solution as drinking water...
December 6, 2017: International Journal of Experimental Pathology
https://www.readbyqxmd.com/read/29208477/impact-of-opioid-therapy-on-sleep-and-respiratory-patterns-in-adults-with-advanced-cancer-receiving-palliative-care
#6
Phillip Good, Ross Pinkerton, Simon Bowler, Justin Craig, Janet Hardy
CONTEXT: In advanced cancer, abnormal sleep patterns may contribute to poor quality of life but the impact of opioid related sleep disorders has not been explored in detail in these patients. OBJECTIVE: To document sleep and respiratory patterns in patients with cancer, receiving a range of opioids, determine factors that contribute to severity of central or obstructive apnoea and to what extent these contribute to sleep disturbance. METHODS: Adults with advanced cancer admitted to a palliative care service underwent a sleep analysis by an unattended polysomnograph...
December 2, 2017: Journal of Pain and Symptom Management
https://www.readbyqxmd.com/read/29207727/effect-of-cellular-mobile-phone-use-and-cetrizine-on-hand-eye-coordination-and-visual-acuity
#7
Kalpita Ganpat Gawit, Smita Anand Tiwari, Gauri Hari Kasabe, Pradeep Kisanrao Deshpande, Balasaheb Baburao Ghongane
Introduction: Cellular mobile phones are a major cause of distraction especially while driving. The aggressive and inappropriate use of cellular mobile phones has increased the risk of accidents. Similar alerts are available in literature for certain substances and drugs (e.g. second generation anti H1 drug -Cetirizine) which also derange psychomotor performance and parameters of alertness. Aim: This study measured variations in hand-eye coordination and visual acuity due to use of cellular mobile phone in comparison to that of commonly used antihistaminic drug viz...
September 2017: Journal of Clinical and Diagnostic Research: JCDR
https://www.readbyqxmd.com/read/29204673/the-role-of-autoantibodies-in-bone-metabolism-and-bone-loss
#8
REVIEW
Barbara Hauser, Ulrike Harre
Many autoimmune diseases are associated with deranged bone metabolism. The resulting localized or systemic bone loss can compromise the quality of life of patients by causing local bone deformities or fragility fractures. There is emerging evidence that antibodies have a direct impact on key players of bone homeostasis, in particular osteoclasts. Clinical and pre-clinical studies provide insight into the function of autoantibodies related to Rheumatoid Arthritis (rheumatoid factor, anti-citrullinated protein antibodies, and anti-carbamylated protein antibodies) and their inflammation-independent interaction with bone cells...
December 4, 2017: Calcified Tissue International
https://www.readbyqxmd.com/read/29202983/influence-of-tibialis-posterior-muscle-activation-on-foot-anatomy-under-axial-loading-a-biomechanical-ct-human-cadaveric-study
#9
Koen Dullaert, Jennifer E Hagen, Paul Simons, Florian Gras, Boyko Gueorguiev, R Geoff Richards, Kajetan Klos
BACKGROUND: Collapse of the medial longitudinal arch and subluxation of the subtalar joint are common occurrences in adult flatfoot deformity. Controversy exists about the role of the tibialis posterior (TP) tendon as first and/or essential lesion. Subtle changes in the foot configuration can occur under weight bearing. PURPOSE: This human cadaveric study is designed to investigate the effect that isolated actuation of the TP tendon has on the medial longitudinal arch and the hindfoot configuration under simulated weight bearing...
December 2017: Foot and Ankle Surgery: Official Journal of the European Society of Foot and Ankle Surgeons
https://www.readbyqxmd.com/read/29201317/nailfold-capillaroscopy-in-430-patients-with-rheumatoid-arthritis
#10
Alireza Rajaei, Pooneh Dehghan, Ali Amiri
Background: Microvascular changes are one of the first obvious steps in numerous inflammatory diseases such as rheumatoid arthritis (RA). Nailfold video capillaroscopy (NFC) is an easy, reliable and safe method for evaluating peripheral microangiopathy. The objective of this study was to examine nailfold microcirculation in RA patients, assess morphological and structural changes quantitatively and qualitatively, and recognize useful changes. Methods: A total of 430 patients diagnosed with RA were examined in a period of 4 years...
2017: Caspian Journal of Internal Medicine
https://www.readbyqxmd.com/read/29196311/unusual-cause-of-encephalopathy-after-brain-surgery
#11
Zayan Mahmooth, James G Malcolm, Jeremy S Wetzel, Faiz U Ahmad
For patients who have had a recent neurosurgical procedure, a visit to the emergency department for encephalopathy may automatically prompt a neurosurgical consult. We present a case of a patient with a history of Chiari malformation decompressed 6 months prior who presented with a 2-week history of slowly progressive altered mental status, headache and imbalance-symptoms consistent with her initial Chiari symptoms, so neurosurgery was consulted. Imaging showed no acute abnormality, but laboratory results revealed metabolic acidosis with high salicylate levels...
December 1, 2017: BMJ Case Reports
https://www.readbyqxmd.com/read/29193756/investigating-the-cardiac-pathology-of-sco2-mediated-hypertrophic-cardiomyopathy-using-patients-induced-pluripotent-stem-cell-derived-cardiomyocytes
#12
Tova Hallas, Binyamin Eisen, Yuval Shemer, Ronen Ben Jehuda, Lucy N Mekies, Shulamit Naor, Revital Schick, Sivan Eliyahu, Irina Reiter, Eugene Vlodavsky, Yeshayahu Shai Katz, Katrin Õunap, Avraham Lorber, Richard Rodenburg, Hanna Mandel, Mihaela Gherghiceanu, Ofer Binah
Mutations in SCO2 are among the most common causes of COX deficiency, resulting in reduced mitochondrial oxidative ATP production capacity, often leading to hypertrophic cardiomyopathy (HCM). To date, none of the recent pertaining reports provide deep understanding of the SCO2 disease pathophysiology. To investigate the cardiac pathology of the disease, we were the first to generate induced pluripotent stem cell (iPSC)-derived cardiomyocytes (iPSC-CMs) from SCO2-mutated patients. For iPSC generation, we reprogrammed skin fibroblasts from two SCO2 patients and healthy controls...
November 28, 2017: Journal of Cellular and Molecular Medicine
https://www.readbyqxmd.com/read/29192360/hyperglycemia-induced-cardiac-contractile-dysfunction-in-the-diabetic-heart
#13
REVIEW
Raphael M Singh, Tahreem Waqar, Frank C Howarth, Ernest Adeghate, Keshore Bidasee, Jaipaul Singh
The development of a diabetic cardiomyopathy is a multifactorial process, and evidence is accumulating that defects in intracellular free calcium concentration [Ca2+]i or its homeostasis are related to impaired mechanical performance of the diabetic heart leading to a reduction in contractile dysfunction. Defects in ryanodine receptor, reduced activity of the sarcoplasmic reticulum calcium pump (SERCA) and, along with reduced activity of the sodium-calcium exchanger (NCX) and alterations in myofilament, collectively cause a calcium imbalance within the diabetic cardiomyocytes...
December 1, 2017: Heart Failure Reviews
https://www.readbyqxmd.com/read/29191087/neuroprotective-effect-of-formononetin-in-ameliorating-learning-and-memory-impairment-in-mouse-model-of-alzheimer-s-disease
#14
Hong-Xin Fei, Ying-Bo Zhang, Ting Liu, Xiao-Jie Zhang, Shu-Liang Wu
Alzheimer's disease (AD) is the most common cause of dementia among elderly population. Deranged β-amyloid (Aβ) trafficking across the blood-brain barrier is known to be a critical element in the pathogenesis of AD. In the vascular endothelial cells of hippocampus, Aβ transport is mainly mediated by low-density lipoprotein-associated protein 1 (LRP1) and the receptor for advanced glycation end (RAGE) products; therefore, LRP1 and RAGE endothelial cells are potential therapeutic targets for AD. In this study, we explored the effects of Formononetin (FMN) on learning and memory improvement in APP/PS1 mice and the related mechanisms...
December 1, 2017: Bioscience, Biotechnology, and Biochemistry
https://www.readbyqxmd.com/read/29190710/the-association-between-depressive-symptoms-and-insulin-resistance-inflammation-and-adiposity-in-men-and-women
#15
M'Balu Webb, Melanie Davies, Nuzhat Ashra, Danielle Bodicoat, Emer Brady, David Webb, Calum Moulton, Khalida Ismail, Kamlesh Khunti
INTRODUCTION: Depression has been shown to be associated with elevated leptin levels, low-grade inflammation and insulin resistance. These derangements are often measured in mixed gender cohorts despite the different body compositions and hormonal environments of men and women and gender-specific prevalence and responses to depression. METHODS: A cross-sectional analysis was carried out on a cohort of 639 participants from the ADDITION-Leicester dataset to assess differences in markers of diabetes risk, cardiovascular risk and inflammation in depressed and non-depressed individuals...
2017: PloS One
https://www.readbyqxmd.com/read/29187144/non-alcoholic-fatty-liver-disease-and-its-associations-among-adolescents-in-an-urban-sri-lankan-community
#16
Shaman Rajindrajith, Arunasalam Pathmeswaran, Chamilka Jayasinghe, Dulani Kottahachchi, Anuradhani Kasturiratne, Shamila T de Silva, Madunil A Niriella, Anuradha S Dassanayake, Arjuna P de Silva, H Janaka de Silva
BACKGROUND: Nonalcoholic fatty liver disease (NAFLD) is a common problem across the world. We aimed to determine the prevalence of NAFLD and its associations in Sri Lankan adolescents living in an urban Sri Lankan community. METHOD: The study population consisted of the birth cohort of the year 2000, residing in the Ragama Medical Officer of Health area. Socio-demographic and anthropometric data [anthropometric measurements, blood pressure and total body fat distribution] of these adolescents were collected by trained data collectors...
November 29, 2017: BMC Gastroenterology
https://www.readbyqxmd.com/read/29182484/ppar%C3%AE-regulates-mitochondrial-structure-and-function-and-hpasmc-proliferation
#17
Samantha M Yeligar, Bum-Yong Kang, Kaiser M Bijli, Jennifer M Kleinhenz, Tamara C Murphy, Gloria Torres, Alejandra San Martin, Roy L Sutliff, C Michael Hart
Pulmonary hypertension (PH) is a progressive disorder that causes significant morbidity and mortality despite existing therapies. PH pathogenesis is characterized by metabolic derangements that increase pulmonary artery smooth muscle cell (PASMC) proliferation and vascular remodeling. PH-associated decreases in peroxisome proliferator-activated receptor gamma (PPARγ) stimulate PASMC proliferation, and PPARγ in coordination with PPARγ coactivator 1 alpha (PGC1α) regulates mitochondrial gene expression and biogenesis...
November 28, 2017: American Journal of Respiratory Cell and Molecular Biology
https://www.readbyqxmd.com/read/29179597/spontaneous-extradural-hematoma-a-rare-entity
#18
Khursheed Alam Khan, Sachin Chhabra, Somnath Sharma, Devendra Purohit
Spontaneous onset extradural hematoma (EDH) is a very rare entity and has been seen mostly to be associated with adjacent infective pathologies, dural vascular malformations, extradural metastasis, or coagulopathies. We report a series of two such cases and review the literature. One case presented with spontaneous EDH that was managed conservatively and was diagnosed to have chronic kidney disease later; the other had deranged coagulation profile and liver function secondary to drug induced hepatitis and was operated...
November 28, 2017: British Journal of Neurosurgery
https://www.readbyqxmd.com/read/29178971/a-41-year-old-man-with-abdominal-pain-deranged-liver-function-and-fevers
#19
James B Maurice, Dominic Yu, Jennifer Watkins
No abstract text is available yet for this article.
November 24, 2017: Gastroenterology
https://www.readbyqxmd.com/read/29178894/changes-in-overall-ventricular-myocardial-architecture-in-the-setting-of-a-porcine-animal-model-of-right-ventricular-dilation
#20
Peter Agger, Christine Ilkjær, Christoffer Laustsen, Morten Smerup, Jesper R Frandsen, Steffen Ringgaard, Michael Pedersen, John B Partridge, Robert H Anderson, Vibeke Hjortdal
BACKGROUND: Chronic pulmonary regurgitation often leads to myocardial dysfunction and heart failure. It is not fully known why secondary hypertrophy cannot fully protect against the increase in wall stress brought about by the increased end-diastolic volume in ventricular dilation. It has been assumed that mural architecture is not deranged in this situation, but we hypothesised that there might be a change in the pattern of orientation of the aggregations of cardiomyocytes, which would contribute to contractile impairment...
November 27, 2017: Journal of Cardiovascular Magnetic Resonance
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