keyword
MENU ▼
Read by QxMD icon Read
search

Thrombosis models

keyword
https://www.readbyqxmd.com/read/28723794/thrombosis-and-antiphospholipid-antibody-syndrome-during-acute-q-fever-a-cross-sectional-study
#1
Matthieu Million, Nathalie Bardin, Simon Bessis, Nadia Nouiakh, Charlaine Douliery, Sophie Edouard, Emmanouil Angelakis, Annick Bosseray, Olivier Epaulard, Stéphanie Branger, Bernard Chaudier, Karine Blanc-Laserre, Nicole Ferreira-Maldent, Elisa Demonchy, France Roblot, Jacques Reynes, Felix Djossou, Camelia Protopopescu, Patrizia Carrieri, Laurence Camoin-Jau, Jean-Louis Mege, Didier Raoult
Q fever is a neglected and potentially fatal disease. During acute Q fever, antiphospholipid antibodies are very prevalent and have been associated with fever, thrombocytopenia, acquired heart valve disease, and progression to chronic endocarditis. However, thrombosis, the main clinical criterion of the 2006 updated classification of the antiphospholipid syndrome, has not been assessed in this context. To test whether thrombosis is associated with antiphospholipid antibodies and whether the criteria for antiphospholipid syndrome can be met in patients with acute Q fever, we conducted a cross-sectional study at the French National Referral Center for Q fever...
July 2017: Medicine (Baltimore)
https://www.readbyqxmd.com/read/28722151/the-antithrombotic-and-haemostatic-effects-of-lassbio-752-a-synthetic-orally-active-compound-in-an-arterial-and-venous-thrombosis-model-in-rats
#2
Flávia S Frattani, Lidia M Lima, Eliezer J Barreiro, Russolina B Zingali
OBJECTIVES: In this work, we further investigated the effect of the compound LASSBio-752 in thrombosis models in rats. METHODS: Arterial and venous thrombosis model, ex-vivo recalcification time and aPTT and PT. KEY FINDINGS: In the venous thrombosis model, oral administration of LASSBio-752 [48.2 mg (100 μmol)/kg] one hour before the thrombus induction decreased thrombus weight by 37 ± 0.2%. Interestingly, the antithrombotic action of this compound [48...
July 19, 2017: Journal of Pharmacy and Pharmacology
https://www.readbyqxmd.com/read/28717801/mimicking-arterial-thrombosis-in-a-3d-printed-microfluidic-in-vitro-vascular-model-based-on-computed-tomography-angiography-data
#3
Pedro F Costa, Hugo J Albers, John E A Linssen, Heleen H T Middelkamp, Linda van der Hout, Robert Passier, Albert van den Berg, Jos Malda, Andries D van der Meer
Arterial thrombosis is the main instigating factor of heart attacks and strokes, which result in over 14 million deaths worldwide every year. The mechanism of thrombosis involves factors from the blood and the vessel wall, and it also relies strongly on 3D vessel geometry and local blood flow patterns. Microfluidic chip-based vascular models allow controlled in vitro studies of the interaction between vessel wall and blood in thrombosis, but until now, they could not fully recapitulate the 3D geometry and blood flow patterns of real-life healthy or diseased arteries...
July 18, 2017: Lab on a Chip
https://www.readbyqxmd.com/read/28717006/extrinsic-sialylation-is-dynamically-regulated-by-systemic-triggers-in-vivo
#4
Charles T Manhardt, Patrick R Punch, Christopher W L Dougher, Joseph T Y Lau
Recent reports documented that extracellular sialyltransferases can remodel both cell surface and secreted glycans by a process other than the canonical cell-autonomous glycosylation that occurs within the intracellular secretory apparatus. Despite association of the abundance of these extracellular sialyltransferases, particularly ST6Gal-1, with disease states such as cancer and a variety of inflammatory conditions, the prevalence of this extrinsic glycosylation pathway in vivo remains unknown. Here we observed no significant extrinsic sialylation in resting mice, suggesting that extrinsic sialylation is not a constitutive process...
July 17, 2017: Journal of Biological Chemistry
https://www.readbyqxmd.com/read/28716153/a-nested-mechanistic-sub-study-into-the-effect-of-tranexamic-acid-versus-placebo-on-intracranial-haemorrhage-and-cerebral-ischaemia-in-isolated-traumatic-brain-injury-study-protocol-for-a-randomised-controlled-trial-crash-3-trial-intracranial-bleeding-mechanistic
#5
Abda Mahmood, Ian Roberts, Haleema Shakur
BACKGROUND: Tranexamic acid prevents blood clots from breaking down and reduces bleeding. However, it is uncertain whether tranexamic acid is effective in traumatic brain injury. The CRASH-3 trial is a randomised controlled trial that will examine the effect of tranexamic acid (versus placebo) on death and disability in 13,000 patients with traumatic brain injury. The CRASH-3 trial hypothesizes that tranexamic acid will reduce intracranial haemorrhage, which will reduce the risk of death...
July 17, 2017: Trials
https://www.readbyqxmd.com/read/28715512/mouse-models-of-deep-vein-thrombosis
#6
T Schönfelder, S Jäckel, P Wenzel
The pathogenesis of venous thromboembolism (VTE) is still not completely understood. Experimental animals in which human deep vein thrombosis can be modeled are useful tools to investigate the pathogenesis of VTE. Besides the availability of transgenic and genetically modified mice, the use of high frequency ultrasound and intravital microscopy plays an important role in identifying thrombotic processes in mouse models. In this article, an overview about the application of various new technologies and existing mouse models is provided, and the impact of venous side branches on deep vein thrombosis in the mouse model is discussed...
2017: Gefässchirurgie: Zeitschrift Für Vaskuläre und Endovaskuläre Chirurgie
https://www.readbyqxmd.com/read/28715386/live-cell-imaging-of-platelet-degranulation-and-secretion-under-flow
#7
Arjan D Barendrecht, Johan J F Verhoef, Silvia Pignatelli, Gerard Pasterkamp, Harry F G Heijnen, Coen Maas
Blood platelets are essential players in hemostasis, the formation of thrombi to seal vascular breaches. They are also involved in thrombosis, the formation of thrombi that occlude the vasculature and injure organs, with life-threatening consequences. This motivates scientific research on platelet function and the development of methods to track cell-biological processes as they occur under flow conditions. A variety of flow models are available for the study of platelet adhesion and aggregation, two key phenomena in platelet biology...
July 10, 2017: Journal of Visualized Experiments: JoVE
https://www.readbyqxmd.com/read/28711718/phospholipase-d1-is-a-regulator-of-platelet-mediated-inflammation
#8
Meike Klier, Nina Sarah Gowert, Sven Jäckel, Christoph Reinhardt, Margitta Elvers
Glycoprotein (GP)Ib is not only required for stable thrombus formation but for platelet-mediated inflammatory responses. Phospholipase (PL)D1 is essential for GPIb-dependent aggregate formation under high shear conditions while nothing is known about PLD1-induced regulation of GPIb in platelet-mediated inflammation and the underlying mechanisms. This study aimed to investigate the relevance of PLD1 for platelet-mediated endothelial and leukocyte recruitment and activation in vitro and in vivo. Pld1(-/-) platelets showed strongly reduced adhesion to TNFα stimulated endothelial cells (ECs) under high shear conditions ex vivo...
July 12, 2017: Cellular Signalling
https://www.readbyqxmd.com/read/28710707/prescription-patterns-of-non-vitamin-k-oral-anticoagulants-across-indications-and-factors-associated-with-their-increased-prescribing-in-atrial-fibrillation-between-2012-2015-a-study-from-the-norwegian-prescription-database
#9
Anna Maria Urbaniak, Bjørn Oddvar Strøm, Randi Krontveit, Kristin Helene Svanqvist
OBJECTIVE: We studied prescription patterns for non-vitamin K oral anticoagulants (NOACs) in Norway between 2012 and 2015, and compared NOAC and warfarin patient characteristics such as age, gender and cardiovascular (CV) co-medications across reimbursed indications. Factors associated with NOAC prescribing in atrial fibrillation (AF) were also analysed. METHODS: All Norwegian patients (N = 156,124) who received at least one dispensed NOAC or warfarin prescription within the indications of AF, deep vein thrombosis and pulmonary embolism (DVT_PE) or prevention of venous thromboembolic events after a hip or knee surgery (VTE_surg) between 2012 and 2015 were included in the study...
July 14, 2017: Drugs & Aging
https://www.readbyqxmd.com/read/28710034/association-of-thrombomodulin-c-1418c-t-polymorphism-and-venous-thromboembolism
#10
Bei Hu, Qing-Yun Wang, Liang Tang, Yu Hu
OBJECTIVES: To investigate the association between thrombomodulin c.1418C>T polymorphism and venous thrombosis. METHODS: Systematic searches of Pubmed, EMBASE, Chinese Biomedical Database, Chinese National Knowledge Infrastructure, the VIP Database and WANFANG Database were performed. Pooled odds ratios (ORs) with 95% confidence intervals (95% CIs) were calculated to assess the strength of the association. Subgroup analysis was conducted to seek for potential sources of heterogeneity...
July 11, 2017: Gene
https://www.readbyqxmd.com/read/28708470/safety-and-efficacy-of-an-absorbable-filter-in-the-inferior-vena-cava-to-prevent-pulmonary-embolism-in-swine
#11
Steven Y Huang, Mitchell Eggers, Mark J McArthur, Katherine A Dixon, Amanda McWatters, Stephen Dria, Lori R Hill, Marites P Melancon, Joseph R Steele, Michael J Wallace
Purpose To evaluate the immediate and long-term safety as well as thrombus-capturing efficacy for 5 weeks after implantation of an absorbable inferior vena cava (IVC) filter in a swine model. Materials and Methods This study was approved by the institutional animal care and use committee. Eleven absorbable IVC filters made from polydioxanone suture were deployed via a catheter in the IVC of 11 swine. Filters remained in situ for 2 weeks (n = 2), 5 weeks (n = 2), 12 weeks (n = 2), 24 weeks (n = 2), and 32 weeks (n = 3)...
July 14, 2017: Radiology
https://www.readbyqxmd.com/read/28707263/delivery-of-viral-vectors-for-gene-therapy-in-intimal-hyperplasia-and-restenosis-in-atherosclerotic-swine
#12
REVIEW
Sannette Hall, Devendra K Agrawal
Cardiovascular diseases including atherosclerosis are a major financial and health burden globally. Inflammation associated with atherosclerosis results in the development of plaques that can rupture causing thrombosis, stroke, or death. The most widely used treatment for the removal of atherosclerotic plaques is percutaneous transluminal coronary angioplasty (PTCA) with or without stenting. Although this is a safer and minimally invasive method, restenosis and intimal hyperplasia after interventional procedure remains a major hurdle and more refined approaches are needed...
July 13, 2017: Drug Delivery and Translational Research
https://www.readbyqxmd.com/read/28707188/hemodynamic-benefits-of-counterpulsation-implantable-percutaneous-and-intraaortic-rotary-blood-pumps-an-in-silico-and-in-vitro-study
#13
Yu Wang, Steven C Koenig, Michael A Sobieski, Mark S Slaughter, Guruprasad A Giridharan
Mechanical circulatory support (MCS) devices have become a standard therapy for heart failure (HF) patients. MCS device designs may differ by level of support, inflow and/or outflow cannulation sites, and mechanism(s) of cardiac unloading and blood flow delivery. Investigation and direct comparison of hemodynamic parameters that help characterize performance of MCS devices has been limited. We quantified cardiac and vascular hemodynamic responses for different types of MCS devices. Continuous flow (CF) left ventricular (LV) assist devices (LVAD) with LV or left atrial (LA) inlet, counterpulsation devices, percutaneous CF LVAD, and intra-aortic rotary blood pumps (IARBP) were quantified using established computer simulation and mock flow loop models...
July 13, 2017: Cardiovascular Engineering and Technology
https://www.readbyqxmd.com/read/28705458/insulin-resistance-and-elevated-c-reactive-protein-among-first-degree-relatives-of-ischemic-stroke-patients
#14
Krishnamoorthy Srilatha, Zachariah Bobby, D K Subrahmanyam, Uppoor NithinKumar
BACKGROUND: Family history is one of the non-modifiable risk factors for ischemic stroke. Atherosclerosis and thrombosis are the two major mechanisms for cardiovascular disease and stroke. Screening of family members is an important method to identify individuals at risk. Therefore, this study was planned to assess the atherosclerotic risk factors in first-degree relatives of patients with ischemic stroke. METHODOLOGY: Case group included 40 first-degree relatives of ischemic stroke patients between 30 and 50 years of age...
July 4, 2017: Diabetes & Metabolic Syndrome
https://www.readbyqxmd.com/read/28700965/inhibitory-effects-of-asp6537-a-selective-cyclooxygenase-1-inhibitor-on-thrombosis-and-neointima-formation-in-rats
#15
Chinatsu Sakata, Tomihisa Kawasaki, Yoshiyuki Iwatsuki, Yumiko Moritani, Yoshiaki Morita, Hideaki Hara
INTRODUCTION: Percutaneous coronary interventions (PCIs), such as balloon angioplasty and stent placement, are effective in the treatment of coronary artery disease. PCI has drawbacks, however, including acute thrombosis after the procedure and restenosis of the vascular lumen due to abnormal neointimal hyperplasia. ASP6537 is a selective COX-1 inhibitor that has been investigated as a possible candidate for clinical development as an antiplatelet agent. In the present study, we evaluated the in vivo antithrombotic effect of ASP6537 and its effect on neointima formation after balloon angioplasty...
July 2, 2017: Thrombosis Research
https://www.readbyqxmd.com/read/28699939/implementing-acove-quality-indicators-as-an-intervention-checklist-to-improve-care-for-hospitalized-older-adults
#16
Liron Sinvani, Andrzej Kozikowski, Christopher Smilios, Vidhi Patel, Guang Qiu, Meredith Akerman, Martin Lesser, David Rosenberg, Gisele Wolf-Klein, Renee Pekmezaris
BACKGROUND: Medicare patients account for approximately 50% of hospital days. Hospitalization in older adults often results in poor outcomes. OBJECTIVE: To test the feasibility and impact of using Assessing Care of Vulnerable Elders (ACOVE) quality indicators (QIs) as a therapeutic intervention to improve care of hospitalized older adults. DESIGN: >Post-test only prospective intervention with a nonequivalent retrospective control group...
July 2017: Journal of Hospital Medicine: An Official Publication of the Society of Hospital Medicine
https://www.readbyqxmd.com/read/28697017/risk-factors-for-deep-vein-thrombosis-and-pulmonary-embolism-after-traumatic-injury-a-competing-risks-analysis
#17
Jan-Michael Van Gent, Richard Y Calvo, Ashley L Zander, Erik J Olson, C Beth Sise, Michael J Sise, Steven R Shackford
BACKGROUND: Venous thromboembolism (VTE), including deep vein thrombosis (DVT) and pulmonary embolism (PE), is typically reported as a composite measure of the quality of trauma center care. Given recent data suggesting post-injury DVT and PE are distinct clinical processes, a better understanding may result from analyzing them as independent, competing events. Using competing risks analysis, we evaluated our hypothesis that the risk factors and timing of post-injury DVT and PE are different...
July 8, 2017: Journal of Trauma and Acute Care Surgery
https://www.readbyqxmd.com/read/28697012/comparison-of-direct-site-endovascular-repair-utilizing-expandable-ptfe-stent-grafts-vs-standard-vascular-shunts-in-a-porcine-sus-scrofa-model
#18
Anders J Davidson, Lucas P Neff, J Kevin Grayson, Nathan F Clement, Erik S DeSoucy, Meryl A Simon-Logan, Christopher M Abbot, James B Sampson, Timothy K Williams
INTRODUCTION: The small diameter of temporary vascular shunts for vascular trauma management may restrict flow and result in ischemia or early thrombosis. We have previously reported a clinical experience with direct, open surgical reconstruction using expanded polytetrafluoroethylene (ePTFE) stent grafts to create a "sutureless" anastomosis as an alternative to standard temporary vascular shunts. We sought to characterize patency and flow characteristics of these grafts compared to standard shunts in a survival model of porcine vascular injury...
July 8, 2017: Journal of Trauma and Acute Care Surgery
https://www.readbyqxmd.com/read/28693359/coagulation-monitoring-correlation-with-heparin-dose-in-pediatric-extracorporeal-life-support
#19
Katie Moynihan, Kerry Johnson, Lahn Straney, Christian Stocker, Ben Anderson, Prem Venugopal, John Roy
OBJECTIVES: Extracorporeal Life Support (ECLS) risks thrombotic and hemorrhagic complications. Optimal anti-coagulation monitoring is controversial. We compared coagulation tests evaluating the heparin effect in pediatric ECLS. METHODS: A retrospective study of children (<18yrs) undergoing ECLS over 12 months in a tertiary pediatric intensive care unit (PICU). Variables included anti-Factor Xa activity (anti-Xa), activated partial thromboplastin time (aPTT), activated clotting time (ACT) and thromboelastogram (TEG(®)6s) parameters: ratio and delta reaction (R) times (the ratio and difference, respectively, between R times in kaolin assays with and without heparinase)...
July 1, 2017: Perfusion
https://www.readbyqxmd.com/read/28689483/the-influence-of-positioning-of-the-nellix-endovascular-aneurysm-sealing-system-on-suprarenal-and-renal-flow-an-in-vitro-study
#20
Johannes T Boersen, Erik Groot Jebbink, Lennart Van de Velde, Michel Versluis, Guillaume Lajoinie, Cornelius H Slump, Jean-Paul P M de Vries, Michel M P J Reijnen
PURPOSE: To examine the influence of device positioning and infrarenal neck diameter on flow patterns in the Nellix endovascular aneurysm sealing (EVAS) system. METHODS: The transition of the aortic flow lumen into two 10-mm-diameter stents after EVAS creates a mismatched area. Flow recirculation may affect local wall shear stress (WSS) profiles and residence time associated with atherosclerosis and thrombosis. To examine these issues, 7 abdominal aortic aneurysm flow phantoms were created, including 3 unstented controls and 3 stented models with infrarenal neck diameters of 24, 28, and 32 mm...
July 1, 2017: Journal of Endovascular Therapy
keyword
keyword
114136
1
2
Fetch more papers »
Fetching more papers... Fetching...
Read by QxMD. Sign in or create an account to discover new knowledge that matter to you.
Remove bar
Read by QxMD icon Read
×

Search Tips

Use Boolean operators: AND/OR

diabetic AND foot
diabetes OR diabetic

Exclude a word using the 'minus' sign

Virchow -triad

Use Parentheses

water AND (cup OR glass)

Add an asterisk (*) at end of a word to include word stems

Neuro* will search for Neurology, Neuroscientist, Neurological, and so on

Use quotes to search for an exact phrase

"primary prevention of cancer"
(heart or cardiac or cardio*) AND arrest -"American Heart Association"