keyword
https://read.qxmd.com/read/37883982/eosinophils-in-traditionally-noneosinophil-rich-dermatoses
#1
JOURNAL ARTICLE
Isabella Sanchez, Marina K Ibraheim, Bonnie A Lee, Christina N Kraus, Ashley Elsensohn
The presence or absence of tissue eosinophilia has previously aided in the diagnosis of inflammatory skin conditions. However, recent studies have elucidated the presence of eosinophils in traditionally eosinophil-poor inflammatory skin diseases, such as dermatomyositis (DM), psoriasis, and lichen sclerosus (LS). This systematic review of the literature explores previous studies of tissue eosinophilia in skin biopsies of dermatoses that are believed to be classically poor in eosinophil. We identified 26 studies, the majority of which were retrospective reviews...
October 26, 2023: American Journal of Dermatopathology
https://read.qxmd.com/read/37701161/nail-whispers-revealing-dermatological-and-systemic-secrets-an-analysis-of-nail-disorders-associated-with-diverse-dermatological-and-systemic-conditions
#2
JOURNAL ARTICLE
Mansi Satasia, Amita H Sutaria
Background and objective Nail disorders encompass a wide spectrum of conditions, spanning congenital, developmental, infectious, neoplastic, degenerative, dermatological, and systemic diseases. A comprehensive exploration of their clinical manifestations, incidence, and associations is crucial for precise diagnosis and effective management. Methods This observational cross-sectional study conducted at B.J. Medical College and Civil Hospital, Ahmedabad involved 300 consecutive patients with nail changes from July 2017 to June 2019 reporting diverse dermatological and systemic conditions...
September 2023: Curēus
https://read.qxmd.com/read/37196296/tacrolimus-in-solution-as-an-option-to-inflammatory-conditions-of-the-scalp
#3
JOURNAL ARTICLE
Camila Scharf, Gaetano Licata, Giulia Briatico, Sebastiano Pellerone, Giuseppe Argenziano, Caterina Mariarosaria Giorgio
INTRODUCTION: Several dermatological diseases lead to inflammatory conditions of the scalp. Most of these afflictions are recalcitrant and require long term maintenance treatment. OBJECTIVES: We present a case series where topical tacrolimus was used in a solution vehicle for these conditions. METHODS: A total of 22 patients (aged 24-90 years) with confirmed diagnosis of lichen planus pilaris (LPP), discoid lupus (DL), frontal fibrosing alopecia (FFA), erosive pustulosis of the scalp (EPS) or folliculitis decalvans (FD) were evaluated and treated with tacrolimus solution (0...
April 1, 2023: Dermatology Practical & Conceptual
https://read.qxmd.com/read/34346097/interleukin-36-expression-in-psoriasis-variants-and-other-dermatologic-diseases-with-psoriasis-like-histopathologic-features
#4
JOURNAL ARTICLE
Terese Monette Aquino, Mary Grace Calvarido, Jeffrey P North
BACKGROUND: Elevated epidermal interleukin (IL)-36 expression distinguishes psoriasis from eczematous dermatitis, but other psoriasiform dermatitides (PD) have not been thoroughly investigated for IL-36 expression. In this study, we assess the IL-36 staining pattern (IL36-SP) in psoriasis variants and other PD including lichen simplex chronicus (LSC), prurigo nodularis (PN), lichen planus (LP), tinea, pityriasis rubra pilaris (PRP), mycosis fungoides (MF), pemphigus foliaceus (PF), acute generalized exanthematous pustulosis (AGEP), impetigo (IMP) and syphilis (SY)...
August 4, 2021: Journal of Cutaneous Pathology
https://read.qxmd.com/read/34156549/alternative-uses-of-ustekinumab-for-non-indicated-dermatological-conditions-a-systematic-review
#5
REVIEW
Sahil Rawal, Sara Kianian, William Guo, Jocellie Marquez, Marissa Ayasse, Katherine A Siamas, Yoojin Lee, Joann Salvemini
Ustekinumab is approved for the treatment of psoriasis and Crohn's disease. Because many dermatological conditions are due to immune-mediated development, ustekinumab may be effective in other conditions. A systematic review of the off-label uses of ustekinumab, as well as on-label adverse effect, was performed, reporting on clinical improvement. MEDLINE, Embase, Web of Science, and Cochrane databases were searched for studies regarding ustekinumab treatment of rativa (HS), lichen planus (LP), pyoderma gangrenosum (PG), pityriasis rubra pilaris (PRP), cutalopecia areata (AA), atopic dermatitis (AD), Bechet's disease, bullous pemphigoid (BP), hidradenitis suppuaneous sarcoidosis, cutaneous systemic lupus erythematosus (SLE), and vitiligo...
August 2022: Archives of Dermatological Research
https://read.qxmd.com/read/33151346/oral-isotretinoin-for-the-treatment-of-dermatologic-conditions-other-than-acne-a-systematic-review-and-discussion-of-future-directions
#6
JOURNAL ARTICLE
Sherman Chu, Lauren Michelle, Chloe Ekelem, Calvin T Sung, Nathan Rojek, Natasha A Mesinkovska
While isotretinoin has been the gold-standard of therapy for severe acne since its approval in 1982, its anti-inflammatory properties makes it a potentially applicable and versatile therapy for a wide variety of dermatologic conditions yet to be explored. This systematic review comprehensively recounts the success of oral isotretinoin in non-acne cutaneous diseases and provide insight into future directions of isotretinoin utility. A systematic literature review was performed using PubMed. Search terms included "isotretinoin" OR "accutane" AND "skin" OR "dermatology" OR "hair" OR "nails" OR "rosacea" OR "psoriasis" OR "pityriasis rubra pilaris" OR "condyloma acuminata" OR "granuloma annulare" OR "darier's disease" OR "non-melanoma skin cancer" OR "frontal fibrosing alopecia" OR "cutaneous lupus erythematosus" OR "hidradenitis suppurativa" OR "photodamaged skin" OR "skin aging" OR "wart" OR "flat warts" OR "plane warts" OR "lichen planus" OR "dissecting cellulitis" OR "folliculitis decalvans" OR "sebaceous hyperplasia" OR "cutaneous t-cell lymphoma" OR "mycosis fungoides...
August 2021: Archives of Dermatological Research
https://read.qxmd.com/read/32555205/erythroderma-a-prospective-study-of-309-patients-followed-for-12-years-in-a-tertiary-center
#7
JOURNAL ARTICLE
Denis Miyashiro, José Antonio Sanches
Erythroderma is characterized by erythema and scaling affecting more than 80% of the body surface area. It is potentially life-threatening, and diagnosis of the underlying disease is a challenge. Despite laboratory improvements, many cases remain idiopathic. We aimed to analyze clinical and laboratory findings of 309 erythrodermic patients to find clues to the etiologic diagnosis. We performed a prospective study at the University of São Paulo Medical School, from 2007 to 2018, with patients with acquired erythroderma...
June 17, 2020: Scientific Reports
https://read.qxmd.com/read/32478949/influence-of-covid-19-pandemic-on-hospitalizations-at-the-tertiary-dermatology-department-in-south-west-poland
#8
JOURNAL ARTICLE
Rafał Białynicki-Birula, Iga Siemasz, Agnieszka Otlewska, Łukasz Matusiak, Jacek C Szepietowski
New virus SARS-Cov-2 infection has spread over the world affecting all daily activities, including functioning of health services. Due to pandemic many hospitals were ordered to re-organize their work. The aim of the current report was to evaluate the influence of COVID-19 pandemic on the hospitalizations at the tertiary dermatology department in south-west Poland. Two corresponding periods of 2019 and 2020 were compared in aspect of number of hospitalizations, sex and age profile of inpatients. We clearly showed a significant reduction of hospitalized patients during the pandemic period, with marked reduction of female patients...
June 1, 2020: Dermatologic Therapy
https://read.qxmd.com/read/31969241/coexistence-of-anogenital-psoriasis-and-genital-warts-is-there-an-optimal-treatment
#9
JOURNAL ARTICLE
Suzana Ljubojević Hadžavdić, Alma Budinšćak, Kristina Žužul, Dragana Ljubojević Grgec, Mihael Skerlev
The prevalence of psoriasis is 2% of the world's population (1). Inverse psoriasis is characterized by the development of erythematous shiny plaques at intertriginous areas of the body. The prevalence of only anogenital involvement appears to be low, but involvement of the anogenital area together with other areas is found in up to 45% of patients with psoriasis (2). A 21-year-old female student with a 3-month history of mild psoriasis (erythematosquamous plaque on the elbows and nail pitting on the nails of the hand) was referred to our Department...
December 2019: Acta Dermatovenerologica Croatica: ADC
https://read.qxmd.com/read/31351991/dermatologic-problems-commonly-seen-by-the-allergist-immunologist
#10
REVIEW
Leah Cohen, Lucia Seminario-Vidal, Richard F Lockey
Allergists/immunologists see a variety of skin disorders, some of which have a known immunologic basis whereas others do not. We review the prevalence, etiology, clinical presentation, and effective and low-cost care of common dermatologic conditions seen in outpatient practices. Conditions discussed include pityriasis alba, seborrheic dermatitis, rosacea, acne, tinea infections, intertrigo, lichen planus, tinea versicolor, lichen simplex chronicus, scabies, pityriasis rosea, keratosis pilaris, and seborrheic keratosis...
January 2020: Journal of Allergy and Clinical Immunology in Practice
https://read.qxmd.com/read/28258757/-frontal-fibrosing-alopecia-a-prospective-study-of-20-cases
#11
JOURNAL ARTICLE
S Elloudi, S Gallouj, M Meziane, F-Z Mernissi, M Rimani
BACKGROUND: Frontal fibrosing alopecia (FFA) is a variant of lichen planopilaris predominantly affecting postmenopausal women. We report a series of 20 cases of FFA and describe the epidemiological, clinical, dermoscopic features and progress under treatment. PATIENTS AND METHODS: This was a prospective study conducted over a period of 16 months in patients seen at the dermatology department of the Hassan II University in Fez, Morocco. RESULTS: Mean patient age was 46 years...
June 2017: Annales de Dermatologie et de Vénéréologie
https://read.qxmd.com/read/28092258/-frontal-fibrosing-alopecia-case-series-and-literature-review
#12
REVIEW
Fátima Tinoco-Fragoso, Judith Domínguez-Cherit, Silvia Méndez-Flores
Frontal fibrosing alopecia is a disease characterized by a symmetric and progressive loss of hair in the fronto-temporal and fronto-parietal lines that generally affects postmenopausal women. It is considered a variant of lichen planus pilaris for its clinical and histopathological features; although, its etiopathology is still unknown. In this report, we analyzed 4 cases of this disease and we discussed its clinical and histopathological characteristics, as well as their course after initiating treatment.
2017: Revista Médica del Instituto Mexicano del Seguro Social
https://read.qxmd.com/read/27613297/dermoscopy-in-general-dermatology-a-practical-overview
#13
REVIEW
Enzo Errichetti, Giuseppe Stinco
Over the last few years, dermoscopy has been shown to be a useful tool in assisting the noninvasive diagnosis of various general dermatological disorders. In this article, we sought to provide an up-to-date practical overview on the use of dermoscopy in general dermatology by analysing the dermoscopic differential diagnosis of relatively common dermatological disorders grouped according to their clinical presentation, i.e. dermatoses presenting with erythematous-desquamative patches/plaques (plaque psoriasis, eczematous dermatitis, pityriasis rosea, mycosis fungoides and subacute cutaneous lupus erythematosus), papulosquamous/papulokeratotic dermatoses (lichen planus, pityriasis rosea, papulosquamous sarcoidosis, guttate psoriasis, pityriasis lichenoides chronica, classical pityriasis rubra pilaris, porokeratosis, lymphomatoid papulosis, papulosquamous chronic GVHD, parakeratosis variegata, Grover disease, Darier disease and BRAF-inhibitor-induced acantholytic dyskeratosis), facial inflammatory skin diseases (rosacea, seborrheic dermatitis, discoid lupus erythematosus, sarcoidosis, cutaneous leishmaniasis, lupus vulgaris, granuloma faciale and demodicidosis), acquired keratodermas (chronic hand eczema, palmar psoriasis, keratoderma due to mycosis fungoides, keratoderma resulting from pityriasis rubra pilaris, tinea manuum, palmar lichen planus and aquagenic palmar keratoderma), sclero-atrophic dermatoses (necrobiosis lipoidica, morphea and cutaneous lichen sclerosus), hypopigmented macular diseases (extragenital guttate lichen sclerosus, achromic pityriasis versicolor, guttate vitiligo, idiopathic guttate hypomelanosis, progressive macular hypomelanosis and postinflammatory hypopigmentations), hyperpigmented maculopapular diseases (pityriasis versicolor, lichen planus pigmentosus, Gougerot-Carteaud syndrome, Dowling-Degos disease, erythema ab igne, macular amyloidosis, lichen amyloidosus, friction melanosis, terra firma-forme dermatosis, urticaria pigmentosa and telangiectasia macularis eruptiva perstans), itchy papulonodular dermatoses (hypertrophic lichen planus, prurigo nodularis, nodular scabies and acquired perforating dermatosis), erythrodermas (due to psoriasis, atopic dermatitis, mycosis fungoides, pityriasis rubra pilaris and scabies), noninfectious balanitis (Zoon's plasma cell balanitis, psoriatic balanitis, seborrheic dermatitis and non-specific balanitis) and erythroplasia of Queyrat, inflammatory cicatricial alopecias (scalp discoid lupus erythematosus, lichen planopilaris, frontal fibrosing alopecia and folliculitis decalvans), nonscarring alopecias (alopecia areata, trichotillomania, androgenetic alopecia and telogen effluvium) and scaling disorders of the scalp (tinea capitis, scalp psoriasis, seborrheic dermatitis and pityriasis amiantacea)...
December 2016: Dermatology and Therapy
https://read.qxmd.com/read/27504295/clinicopathological-study-of-non-infectious-erythaematous-papulosquamous-skin-diseases
#14
JOURNAL ARTICLE
Sushma Hosamane, Muktha Pai, Thoppil Reba Philipose, Umaru Nayarmoole
INTRODUCTION: Papulosquamous diseases are characterized by scaly papules and plaques with similar clinical picture which amounts to confusion and hence, a definitive histopathological diagnosis goes a long way in treatment of such diseases. AIM: The aim of the study was to study the histomorphology of non-infectious, erythaematous, papulosquamous lesions of skin with clinicopathological correlation. MATERIALS AND METHODS: Skin biopsies from 150 clinically diagnosed/suspected non-infectious erythaematous, papulosquamous skin diseases were received in the Department of Pathology...
June 2016: Journal of Clinical and Diagnostic Research: JCDR
https://read.qxmd.com/read/26352467/unique-cutaneous-reaction-to-second-and-third-generation-tyrosine-kinase-inhibitors-for-chronic-myeloid-leukemia
#15
JOURNAL ARTICLE
Anisha B Patel, Alvin R Solomon, Michael J Mauro, Benjamin D Ehst
BACKGROUND: Recently developed tyrosine kinase inhibitors (TKIs) offer first-line alternatives to patients with chronic myeloid leukemia. While these medications are generally well tolerated, cutaneous reactions occur frequently and can present a management challenge. We describe a newly recognized skin reaction to dasatinib and nilotinib and extend it to the newer agent ponatinib. OBSERVATIONS: Nine patients developed varying degrees of a clinically and histopathologically lichenoid exanthem comprised of erythematous, predominately follicular papules with scale and alopecia...
2016: Dermatology: International Journal for Clinical and Investigative Dermatology
https://read.qxmd.com/read/26158366/a-case-of-graham-little-piccardi-lasseur-syndrome
#16
JOURNAL ARTICLE
Ahu Yorulmaz, Ferda Artuz, Olcay Er, Servet Guresci
Graham-Little-Piccardi-Lasseur Syndrome (GLPLS) is a variant of lichen planopilaris, which is characterized by progressive cicatricial alopecia of scalp, non-cicatricial alopecia of axillae and pubic regions, and keratosis pilaris-like follicular papules over trunk and extremities. GLPLS is a disease of unknown etiology. However, recent reports support a central role for a T-cell-mediated immune response in the pathogenesis of GLPLS. Besides, although GLPLS is believed to occur sporadically, a genetic predisposition also has been implicated in the pathogenesis...
June 16, 2015: Dermatology Online Journal
https://read.qxmd.com/read/26086412/the-practical-usefulness-of-dermoscopy-in-general-dermatology
#17
REVIEW
E Errichetti, G Stinco
Beside to traditional use, dermoscopy is more and more used in the assessment of other "general" dermatologic conditions, namely scalp and hair disorders (trichoscopy), nails abnormalities (onychoscopy), skin infections and infestations (entomodermoscopy), and cutaneous inflammatory diseases (inflammoscopy). Among the list of new applications of dermoscopy, the study of inflammatory dermatoses is probably the most promising topic in terms of development and usefulness, considering the large number of such disorders and the frequent problems in their differential diagnosis which the dermatologist encounters in own daily clinical practice...
October 2015: Giornale Italiano di Dermatologia e Venereologia: Organo Ufficiale, Società Italiana di Dermatologia e Sifilografia
https://read.qxmd.com/read/22037625/expression-of-bleomycin-hydrolase-in-keratinization-disorders
#18
JOURNAL ARTICLE
Yayoi Kamata, Hideki Maejima, Akira Watarai, Norimitsu Saito, Kensei Katsuoka, Atsushi Takeda, Kazuhiko Ishihara
A neutral cysteine protease, bleomycin hydrolase (BH), is widely expressed in mammalian tissues, with the skin seeming to contain the highest level. Our previous study revealed that BH transcription is modulated both during differentiation and by cytokines. However, BH involvement in keratinization disorder is not well known. In the present study, we performed immunohistochemical studies of BH and other serine/cysteine proteases in human normal skin and lesional skin with keratinization disorders. BH-positive cells were detected in granular layers of orthokeratotic and hyperkeratotic skin diseases, such as erythrokeratoderma and lichen planus...
January 2012: Archives of Dermatological Research
https://read.qxmd.com/read/22007931/off-label-use-of-fumarate-therapy-for-granulomatous-and-inflammatory-skin-diseases-other-than-psoriasis-vulgaris-a-retrospective-study
#19
JOURNAL ARTICLE
A Klein, B Coras, M Landthaler, P Babilas
BACKGROUND: Fumarates are approved for the systemic treatment of moderate and severe psoriasis vulgaris in Germany. However, a number of studies and case reports indicate their efficacy in the treatment of further inflammatory skin disorders or granulomatous skin diseases. OBJECTIVES: To examine the efficacy and safety of fumarates for the treatment of granulomatous and inflammatory skin diseases other than psoriasis vulgaris. PATIENTS AND METHODS: The therapeutic efficacy and side-effects of fumarate therapy were analysed retrospectively in patients with granuloma annulare (GA, n = 4), cutaneous sarcoidosis (SA, n = 1), lichen planus (LP, n = 3), pityriasis rubra pilaris (PRP, n = 1) or chronic discoid lupus erythematosus (CDLE, n = 1)...
November 2012: Journal of the European Academy of Dermatology and Venereology: JEADV
https://read.qxmd.com/read/21482898/off-label-use-of-azathioprine-in-dermatology-a-systematic-review
#20
REVIEW
Mandy E Schram, Rinke J Borgonjen, Cathelijne M J M Bik, Jan G van der Schroeff, Jannes J E van Everdingen, Phyllis I Spuls
OBJECTIVE: To summarize evidence regarding the effectiveness, efficacy, and safety of off-label azathioprine use in dermatology. DATA SOURCES: We searched the MEDLINE (1950-2009), EMBASE (1980-2009), and CENTRAL (1996-2009) databases on October 9, 2009. The main search terms were azathioprine and its synonyms. No restrictions were imposed regarding publication date. Only articles in English, French, German, or Dutch were included. STUDY SELECTION: Randomized controlled trials, cohorts, and case series concerning the use of azathioprine in an off-label dermatologic setting were independently assessed for eligibility by 2 coauthors...
April 2011: Archives of Dermatology
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