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Thomas W Hamilton, Louise H Strickland, Hemant G Pandit
BACKGROUND: Total knee arthroplasty is a painful procedure, with approximately half of patients reporting severe pain during the early postoperative period. Gabapentinoids are used as an adjunct for the management of acute pain in approximately half of enhanced recovery programs. We performed a meta-analysis to assess the effectiveness and safety of gabapentinoids for the treatment of acute postoperative pain following total knee arthroplasty. METHODS: Randomized controlled trials of patients undergoing elective primary total knee arthroplasty that compared the use of the gabapentinoid class of drugs (gabapentin [Neurontin; Pfizer]) or pregabalin [Lyrica; Pfizer]) with that of placebo were retrieved, with 12 studies meeting inclusion criteria...
August 17, 2016: Journal of Bone and Joint Surgery. American Volume
James Offord, Lori L Isom
In the post-genomic era, the idea of using the sequence of a protein to determine its potential role as a drug target has gained currency. The goal of this approach to drug discovery is to use the sequence of a protein that is known to bind a specific ligand or drug, along with the known structure of the ligand binding site, to predict other similar proteins that are also "druggable". Gabapentin (Neurontin) and pregabalin (Lyrica) are drugs currently in the clinic that were developed based on the hypothesis that generating non-hydrolyzable analogs of GABA would lead to the development of antiepileptic agents...
July 2015: Critical Reviews in Biochemistry and Molecular Biology
Rachel K Berlin, Paul M Butler, Michael D Perloff
OBJECTIVE: Gabapentin is commonly used off-label in the treatment of psychiatric disorders with success, failure, and controversy. A systematic review of the literature was performed to elucidate the evidence for clinical benefit of gabapentin in psychiatric disorders. DATA SOURCES: Bibliographic reference searches for gabapentin use in psychiatric disorders were performed in PubMed and Ovid MEDLINE search engines with no language restrictions from January 1, 1983, to October 1, 2014, excluding nonhuman studies...
2015: Primary Care Companion to CNS Disorders
Antoni Sicras-Mainar, Javier Rejas-Gutiérrez, Ruth Navarro-Artieda
OBJECTIVE: To explore adherence/persistence with generic gabapentin/venlafaxine versus brand-name gabapentin/venlafaxine (Neurontin(®)/Vandral(®)) in peripheral neuropathic pain (pNP) or generalized anxiety disorder (GAD), respectively, and whether it is translated into different costs and patient outcomes in routine medical practice. METHODS: A retrospective, new-user cohort study was designed. Electronic medical records (EMR) of patients included in the health plan of Badalona Serveis Assistencials SA, Barcelona, Spain were exhaustively extracted for analysis...
2015: ClinicoEconomics and Outcomes Research: CEOR
Thomas Kampfrath, Penny Peng, Valli Vairavan, Dayong Lee
CLINICAL HISTORY: HASH(0x43876f8) PATIENT: 41-year-old Hispanic woman. Chief Complaint: Pain in the neck, joints, and shoulders that started in August 2013. History of Present Illness: The patient has a history of psychiatric illness. Her primary care physician from an outside facility had prescribed alprazolam (Xanax) to treat her depression. The patient reported that in 2011 she experienced pain in the right side of her back and was diagnosed with sciatica. In addition, she was diagnosed with systemic lupus erythematosus (SLE) based on a positive finding for antinuclear antibodies (ANA) and double-stranded DNA (ds-DNA)...
2015: Laboratory Medicine
F Lee Cantrell, Othon Mena, Ray D Gary, Iain M McIntyre
Gabapentin (GBP) (Neurontin®, Horizant®, Gralise®) is a widely prescribed medication used primarily for the treatment of epilepsy and neuropathic pain. GBP has a favorable adverse effect profile in therapeutic dosing with the most common reported effects being dizziness, fatigue, drowsiness, weight gain, and peripheral edema. Even with intentional GBP self-poisonings, serious effects are rare. A 47-year-old female was found dead at work with her daughter's bottle of GBP 600 mg. There were 26 tablets missing and the decedent's only known medication was hydrocodone/acetaminophen...
July 2015: International Journal of Legal Medicine
Supattra Kantito, Supattra Kantito, Natthiya Tantisiriwat, Krisna Piravej
OBJECTIVE: To compare effectiveness of the generic form of gabapentin with its original form. MATERIAL AND METHOD: A single-blind evaluation randomized controlled trial (RCT) of patients that were diagnosed with low back pain with suspected neuropathic component at the Department of Rehabilitation Medicine, King Chulalongkorn Memorial Hospital were included in the present study. Patients were randomized into two treatment groups. The first group received gabapentin generic form (GGF) or Gabapentin Sandoz, whereas the other received gabapentin original form (GOF) or Neurontin...
July 2014: Journal of the Medical Association of Thailand, Chotmaihet Thangphaet
Maria A Sullivan, Robert Wilbur
This clinical study reports upon the efficacy of gabapentin (Neurontin) for treating severe akathisia (3 on the Barnes Akathisia Rating Scale) in two patients receiving quetiapine (Seroquel), one of whom also received olanzapine (Zyprexa) for a short period. The first patient participated in an open-label experiment in which the bedtime dose of gabapentin was discontinued three times at intervals 1 week apart, resulting in severe akathisia which was quickly terminated by taking his usual 1200 mg gabapentin dose...
April 2014: Therapeutic Advances in Psychopharmacology
Heather M Starmer, WuYang Yang, Raju Raval, Christine G Gourin, Marian Richardson, Rachit Kumar, Bronwyn Jones, Todd McNutt, Zhi Cheng, Sierra Cheng, Harry Quon
The aim of this study was to examine the impact of gabapentin (neurontin) on swallowing and feeding tube use during chemoradiation (CRT) for oropharyngeal squamous cell carcinoma (OPSCC), and physiologic swallowing outcomes following completion of treatment. A total of 23 patients treated for OPSCC with concurrent CRT and prophylactically treated for pain using gabapentin were assessed. Historical controls were matched for T stage and primary site of disease. Timing of PEG use and removal were recorded. Video fluoroscopic swallowing studies were completed post-treatment to assess physiologic outcomes as well as penetration-aspiration scores (PAS)...
June 2014: Dysphagia
Noah Scheinfeld
Hidradenitis Supprurativa is a painful dermatological condition. Although the pain of HS has unique aspects, the pain of HS pain shares common elements with essential pain, fibromyalgia, and pure neuropathic pain syndromes. Futhermore, depression plays an important role in the pain of HS. This paper reviews the potential for use of nonsteroidal anti-inflammatory drug (NSAIDS), acetaminophen, celecoxib, gabpentin, pregabalin, and the serotonin and norepinephrine reuptake inhibitors (SNRIs), duloxetine and venlafaxine, for treating HS related pain...
November 2013: Dermatology Online Journal
George Muller
Lower back pain in cats, especially that caused by intervertebral disk disease, inhibits movement, greatly compromises quality of life, and, without treatment can persist unabated long term. The basic diagnostic workup available to many feline patients with low back discomfort can yield inconclusive results, and in confirmed cases of intervertebral disk disease, decompression surgery can be relatively expensive for the client and not without risk to the patient. Thus empirical treatment with an effective analgesic that is safe for and well tolerated by cats with low back pain is a welcome and reasonable option for many pet owners...
May 2010: International Journal of Pharmaceutical Compounding
Manisha Yadav, Judith Volkar
About 80% of postmenopausal women experience vasomotor symptoms, such as hot flashes and night sweats - symptoms that are associated with sleep disruption and can lead to fatigue and mood changes. Moreover, hot flashes can be embarrassing for women, causing difficulties at work and in their social lives. Many therapies have been advocated for relief of vasomotor symptoms, but only hormone therapy has been US Food and Drug Administration approved. However, after the Women's Health Initiative Study suggested that there was a correlation between hormone therapy and increased risk for breast cancer and cardiovascular events, many women stopped taking hormone therapy, and many do not want to initiate it...
2013: International Journal of General Medicine
Jae Ho Lee, Hyun Kyu Lee, Na Hyung Chun, Yoon So, Chi Young Lim
BACKGROUND: Postoperative sore throat (POST) is considered a usual complication after tracheal intubation, especially, thyroid surgery. Gabapentin is a widely studied multimodal perioperative drug, which can be used to treat acute postoperative pain. The primary endpoints of this study was a reduction of the incidence of POST at rest and during the swallowing movements after thyroid surgery. And the second endpoints was a reduction of the intensity of the POST after thyroid surgery. METHODS: Seventy-one patients that underwent elective thyroid surgery received either gabapentin (Neurontin™ 600 mg) or placebo, orally, one hour before anesthesia...
February 2013: Korean Journal of Anesthesiology
Cuiping Chen, Chien-Hsuan Sara Han, Michael Sweeney, Verne E Cowles
Neurontin®, an immediate-release (IR) formulation of gabapentin, was the first drug approved by the United States Food and Drug Administration for the treatment of postherpetic neuralgia (PHN). The effective dosing regimen of gabapentin IR (G-IR) for PHN is 1800 mg/day in three divided doses. In 2011, a gastroretentive (GR) formulation of gabapentin (G-GR, Gralise®) was approved for the treatment of PHN. The effective dosing regimen of G-GR is 1800 mg, once daily taken with the evening meal. Compared with G-IR, G-GR has an apparently better tolerability profile with a 1-2 weeks shorter titration period to reach the same therapeutically effective dose...
April 2013: Journal of Pharmaceutical Sciences
Christian J Krautkramer
No abstract text is available yet for this article.
2006: Virtual Mentor: VM
Cuiping Chen, Verne E Cowles, Michael Sweeney
Gabapentin is approved for the treatment of postherpetic neuralgia (PHN) and epilepsy. The pharmacokinetic (PK) properties of gabapentin, including absorption, distribution, metabolism, and excretion (ADME), were investigated during the development of Neurontin®, an immediate-release (IR) formulation of gabapentin that is orally administered three-times daily. Recently, a gastroretentive (GR) once-daily formulation of gabapentin (Gralise®) has been developed and marketed for the treatment of PHN. This review focuses on the ADME properties of gabapentin and illustrates how GR delivery enhances its absorption compared with IR formulations and allows once-daily dosing with the evening meal for the treatment of PHN...
February 1, 2013: Current Clinical Pharmacology
Alexander G Rabchevsky, Samir P Patel, Travis S Lyttle, Khalid C Eldahan, Christopher R O'Dell, Yi Zhang, Phillip G Popovich, Patrick H Kitzman, Kevin D Donohue
We recently reported that the neuropathic pain medication, gabapentin (GBP; Neurontin), significantly attenuated both noxious colorectal distension (CRD)-induced autonomic dysreflexia (AD) and tail pinch-induced spasticity compared to saline-treated cohorts 2-3 weeks after complete high thoracic (T4) spinal cord injury (SCI). Here we employed long-term blood pressure telemetry to test, firstly, the efficacy of daily versus acute GBP treatment in modulating AD and tail spasticity in response to noxious stimuli at 2 and 3 weeks post-injury...
2012: Frontiers in Physiology
S Swaroop Vedula, Palko S Goldman, Ilyas J Rona, Thomas M Greene, Kay Dickersin
BACKGROUND: Previous studies have documented strategies to promote off-label use of drugs using journal publications and other means. Few studies have presented internal company communications that discussed financial reasons for manipulating the scholarly record related to off-label indications. The objective of this study was to build on previous studies to illustrate implementation of a publication strategy by the drug manufacturer for four off-label uses of gabapentin (Neurontin, Pfizer, Inc...
2012: Trials
Jørgen G Bramness, Pål Sandvik, Anders Engeland, Svetlana Skurtveit
Pregabalin (Lyrica(®) ) may have an anxiolytic effect. It has also been reported that the use of this drug helps prevent excessive use of benzodiazepines. The aim of the present study was to examine if pregabalin reduced the intake of benzodiazepines. In a pharmacoepidemiological study, we compared pregabalin to the older drug gabapentin (Neurontin(®) ) in the Norwegian Prescription Database. The database has total capture of all prescribed drugs outside institutions. We identified all prescriptions for the two drugs for patients aged 18-69 years between 2004 and 2007...
November 2010: Basic & Clinical Pharmacology & Toxicology
Zhoumou Chen, Kali Janes, Collin Chen, Tim Doyle, Leesa Bryant, Dilip K Tosh, Kenneth A Jacobson, Daniela Salvemini
Clinical management of chronic neuropathic pain is limited by marginal effectiveness and unacceptable side effects of current drugs. We demonstrate A(3) adenosine receptor (A(3)AR) agonism as a new target-based therapeutic strategy. The development of mechanoallodynia in a well-characterized mouse model of neuropathic pain following chronic constriction injury of the sciatic nerve was rapidly and dose-dependently reversed by the A(3)AR agonists: IB-MECA, its 2-chlorinated analog (Cl-IB-MECA), and the structurally distinct MRS1898...
May 2012: FASEB Journal: Official Publication of the Federation of American Societies for Experimental Biology
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