keyword
https://read.qxmd.com/read/38546883/beyond-hormones-investigating-the-impact-of-progesterone-receptor-membrane-component-1-in-lung-adenocarcinoma
#1
JOURNAL ARTICLE
Solaipriya Solairaja, Sivaramakrishnan Venkatabalasubramanian
Progesterone Receptor Membrane Component 1 (PGRMC1) is a candidate oncogene with a prominent involvement in the pathogenesis of diverse cancers (ovarian, thyroid, breast, colon, head, and neck). Our study ascertains the ability of PGRMC1 to influence WNT members in the non-small cell lung cancer subtype-lung adenocarcinoma (LUAD) and participates in augmented cell proliferation and migration. Both computational and in vitro experimental analyses were performed in this study. Gene silencing, in vitro assays, gene expression & and protein expression studies were performed to ascertain the role of PGRMC1 in LUAD cells...
March 28, 2024: Journal of Membrane Biology
https://read.qxmd.com/read/38546380/muramyl-dipeptide-causes-mitochondrial-dysfunction-and-intestinal-inflammatory-cytokine-responses-in-rats
#2
JOURNAL ARTICLE
Lu-Jia Zhao, Xiao-Yong Dai, You-Wen Ye, Xiu-Feng Pang, Meng Jiang, Wan-Yi Tan, Ying-Hui Xu, Ji-Feng Su, Bin Shi
INTRODUCTION: Intestinal flora and the translocation of its products, such as muramyl dipeptide (MDP), are common causes of sepsis. MDP is a common activator of the intracellular pattern recognition receptor NOD2, and MDP translocation can cause inflammatory damage to the small intestine and systemic inflammatory responses in rats. Therefore, this study investigated the effects of MDP on the intestinal mucosa and distant organs during sepsis and the role of the NOD2/AMPK/LC3 pathway in MDP-induced mitochondrial dysfunction in the intestinal epithelium...
March 28, 2024: Shock
https://read.qxmd.com/read/38544741/-cmpx-overexpression-in-pseudomonas-aeruginosa-affects-biofilm-formation-and-cell-morphology-in-response-to-shear-stress
#3
JOURNAL ARTICLE
Audrey David, Mélissande Louis, Ali Tahrioui, Sophie Rodrigues, Clarisse Labbé, Olivier Maillot, Magalie Barreau, Olivier Lesouhaitier, Pierre Cornelis, Sylvie Chevalier, Emeline Bouffartigues
UNLABELLED: Pseudomonas aeruginosa is an opportunistic pathogen causing chronic infections that are related to its ability to form biofilms. Mechanosensitive ion channels (Mcs) are cytoplasmic membrane proteins whose opening depends on a mechanical stress impacting the lipid bilayer. CmpX is a homologue of the small conductance MscS of Escherichia coli . The cmpX gene is part of a transcriptional cfrX-cmpX unit that is under the control of the cell envelope stress response ECF sigma factor SigX...
June 2024: Biofilm
https://read.qxmd.com/read/38543112/targeting-smad-dependent-signaling-considerations-in-epithelial-and-mesenchymal-solid-tumors
#4
REVIEW
Farhana Runa, Gabriela Ortiz-Soto, Natan Roberto de Barros, Jonathan A Kelber
SMADs are the canonical intracellular effector proteins of the TGF-β (transforming growth factor-β). SMADs translocate from plasma membrane receptors to the nucleus regulated by many SMAD-interacting proteins through phosphorylation and other post-translational modifications that govern their nucleocytoplasmic shuttling and subsequent transcriptional activity. The signaling pathway of TGF-β/SMAD exhibits both tumor-suppressing and tumor-promoting phenotypes in epithelial-derived solid tumors...
March 1, 2024: Pharmaceuticals
https://read.qxmd.com/read/38536815/osbp-mediated-pi-4-p-cholesterol-exchange-at-endoplasmic-reticulum-secretory-granule-contact-sites-controls-insulin-secretion
#5
JOURNAL ARTICLE
Styliani Panagiotou, Kia Wee Tan, Phuoc My Nguyen, Andreas Müller, Affiong Ika Oqua, Alejandra Tomas, Anna Wendt, Lena Eliasson, Anders Tengholm, Michele Solimena, Olof Idevall-Hagren
Insulin is packaged into secretory granules that depart the Golgi and undergo a maturation process that involves changes in the protein and lipid composition of the granules. Here, we show that insulin secretory granules form physical contacts with the endoplasmic reticulum and that the lipid exchange protein oxysterol-binding protein (OSBP) is recruited to these sites in a Ca2+ -dependent manner. OSBP binding to insulin granules is positively regulated by phosphatidylinositol-4 (PI4)-kinases and negatively regulated by the PI4 phosphate (PI(4)P) phosphatase Sac2...
March 26, 2024: Cell Reports
https://read.qxmd.com/read/38534107/signaling-through-the-salmonella-pbga-lapb-regulatory-complex-activates-lpxc-proteolysis-and-limits-lipopolysaccharide-biogenesis-during-stationary-phase-growth
#6
JOURNAL ARTICLE
Joshua A Mettlach, Melina B Cian, Medha Chakraborty, Zachary D Dalebroux
Salmonella enterica serovar Typhimurium ( S . Typhimurium) controls lipopolysaccharide (LPS) biosynthesis by regulating proteolysis of LpxC, the rate-limiting enzyme and target of preclinical antibiotics. PbgA/YejM/LapC regulates LpxC levels and controls outer membrane (OM) LPS composition at the log-to-stationary phase transition. Suppressor substitutions in <u>L</u>PS <u>a</u>ssembly <u>p</u>rotein <u>B</u> (LapB/YciM) rescue the LPS and OM integrity defects of pbgA -mutant S ...
March 27, 2024: Journal of Bacteriology
https://read.qxmd.com/read/38533975/cgmp-dependent-kinase-2-na-h-exchanger-nhe3-and-pdz-adaptor-nherf2-co-assemble-in-apical-membrane-microdomains
#7
JOURNAL ARTICLE
Min Luo, Yongjian Liu, Katerina Nikolovska, Brigitte Riederer, Enrico Patrucco, Franz Hofmann, Ursula Seidler
AIM: Trafficking, membrane retention, and signal-specific regulation of the Na+ /H+ exchanger 3 (NHE3) are modulated by the Na+ /H+ Exchanger Regulatory Factor (NHERF) family of PDZ-adapter proteins. This study explored the assembly of NHE3 and NHERF2 with the cGMP-dependent kinase II (cGKII) within detergent-resistant membrane microdomains (DRMs, "lipid rafts") during in vivo guanylate cycle C receptor (Gucy2c) activation in murine small intestine. METHODS: Small intestinal brush border membranes (siBBMs) were isolated from wild type, NHE3-deficient, cGMP-kinase II-deficient, and NHERF2-deficient mice, after oral application of the heat-stable Escherichia coli toxin (STa) analog linaclotide...
March 27, 2024: Acta Physiologica
https://read.qxmd.com/read/38533085/membrane-trafficking-alterations-in-breast-cancer-progression
#8
REVIEW
Andreia Ferreira, Pedro Castanheira, Cristina Escrevente, Duarte C Barral, Teresa Barona
Breast cancer (BC) is the most common type of cancer in women, and remains one of the major causes of death in women worldwide. It is now well established that alterations in membrane trafficking are implicated in BC progression. Indeed, membrane trafficking pathways regulate BC cell proliferation, migration, invasion, and metastasis. The 22 members of the ADP-ribosylation factor (ARF) and the >60 members of the rat sarcoma (RAS)-related in brain (RAB) families of small GTP-binding proteins (GTPases), which belong to the RAS superfamily, are master regulators of membrane trafficking pathways...
2024: Frontiers in Cell and Developmental Biology
https://read.qxmd.com/read/38530063/-not-available
#9
REVIEW
Liyan Jia, Shan Gao, Yan Qiao
Liquid-liquid phase separation (LLPS) is responsible for the emergence of intracellular membrane-less organelles and the development of coacervate protocells. Benefitting from the advantages of simplicity, precision, programmability, and noninvasiveness, light has become an effective tool to regulate the assembly dynamics of LLPS, and mediate various biochemical processes associated with LLPS. In this review, recent advances in optically controlling membrane-less organelles within living organisms are summarized, thereby modulating a series of biological processes including irreversible protein aggregation pathologies, transcription activation, metabolic flux, genomic rearrangements, and enzymatic reactions...
March 26, 2024: Small Methods
https://read.qxmd.com/read/38529373/hmgb1-rage-axis-in-tumor-development-unraveling-its-significance
#10
REVIEW
Anqi Fan, Mengxiang Gao, Xuhuan Tang, Mengya Jiao, Chenchen Wang, Yingying Wei, Quan Gong, Jixin Zhong
High mobility group protein 1 (HMGB1) plays a complex role in tumor biology. When released into the extracellular space, it binds to the receptor for advanced glycation end products (RAGE) located on the cell membrane, playing an important role in tumor development by regulating a number of biological processes and signal pathways. In this review, we outline the multifaceted functions of the HMGB1/RAGE axis, which encompasses tumor cell proliferation, apoptosis, autophagy, metastasis, and angiogenesis. This axis is instrumental in tumor progression, promoting tumor cell proliferation, autophagy, metastasis, and angiogenesis while inhibiting apoptosis, through pivotal signaling pathways, including MAPK, NF-κB, PI3K/AKT, ERK, and STAT3...
2024: Frontiers in Oncology
https://read.qxmd.com/read/38527911/discovery-of-glpg2737-a-potent-type-2-corrector-of-cftr-for-the-treatment-of-cystic-fibrosis-in-combination-with-a-potentiator-and-a-type-1-co-corrector
#11
JOURNAL ARTICLE
Mathieu Pizzonero, Rhalid Akkari, Xavier Bock, Romain Gosmini, Elsa De Lemos, Béranger Duthion, Gregory Newsome, Thi-Thu-Trang Mai, Virginie Roques, Hélène Jary, Jean-Michel Lefrancois, Laetitia Cherel, Vanessa Quenehen, Marielle Babel, Nuria Merayo, Natacha Bienvenu, Oscar Mammoliti, Ghjuvanni Coti, Adeline Palisse, Marlon Cowart, Anurupa Shrestha, Stephen Greszler, Steven Van Der Plas, Koen Jansen, Pieter Claes, Mia Jans, Maarten Gees, Monica Borgonovi, Gert De Wilde, Katja Conrath
Cystic fibrosis (CF) is caused by mutations in the CF transmembrane conductance regulator (CFTR) protein. This epithelial anion channel regulates the active transport of chloride and bicarbonate ions across membranes. Mutations result in reduced surface expression of CFTR channels with impaired functionality. Correctors are small molecules that support the trafficking of CFTR to increase its membrane expression. Such correctors can have different mechanisms of action. Combinations may result in a further improved therapeutic benefit...
March 25, 2024: Journal of Medicinal Chemistry
https://read.qxmd.com/read/38513518/wheat-brevis-radix-brx-regulates-organ-size-stomatal-density-and-enhances-drought-tolerance-in-arabidopsis
#12
JOURNAL ARTICLE
Sneha Tiwari, M Nagaraj Kumar, Aruna Kumar, Monika Dalal
BREVIS RADIX (BRX) is a small plant-specific and evolutionary conserved gene family with divergent yet partially redundant biological functions including root and shoot growth, stomatal development and tiller angle in plants. We characterized a BRX family gene from wheat (Triticum aestivum) by gain-of-function in Arabidopsis. Overexpression of TaBRXL2A resulted in longer primary roots with increased root meristem size and higher root growth under control and exogenous hormone treatments as compared to wild type (Col-0) plants...
March 15, 2024: Plant Physiology and Biochemistry: PPB
https://read.qxmd.com/read/38511926/genome-wide-profiling-of-hfq-bound-rnas-reveals-the-iron-responsive-small-rna-rust-in-caulobacter-crescentus
#13
JOURNAL ARTICLE
Laura N Vogt, Gaël Panis, Anna Schäpers, Nikolai Peschek, Michaela Huber, Kai Papenfort, Patrick H Viollier, Kathrin S Fröhlich
The alphaproteobacterium Caulobacter crescentus thrives in oligotrophic environments and is able to optimally exploit minimal resources by entertaining an intricate network of gene expression control mechanisms. Numerous transcriptional activators and repressors have been reported to contribute to these processes, but only few studies have focused on regulation at the post-transcriptional level in C. crescentus . Small RNAs (sRNAs) are a prominent class of regulators of bacterial gene expression, and most sRNAs characterized today engage in direct base-pairing interactions to modulate the translation and/or stability of target mRNAs...
March 21, 2024: MBio
https://read.qxmd.com/read/38510242/antibody-dependent-cellular-cytotoxicity-inducing-anti-egfr-antibodies-as-effective-therapeutic-option-for-cutaneous-melanoma-resistant-to-braf-inhibitors
#14
JOURNAL ARTICLE
Elena Muraro, Barbara Montico, Benedict Lum, Francesca Colizzi, Giorgio Giurato, Annamaria Salvati, Roberto Guerrieri, Aurora Rizzo, Elisa Comaro, Vincenzo Canzonieri, Andrea Anichini, Michele Del Vecchio, Roberta Mortarini, Massimo Milione, Alessandro Weisz, Maria Antonietta Pizzichetta, Fiona Simpson, Riccardo Dolcetti, Elisabetta Fratta, Luca Sigalotti
INTRODUCTION: About 50% of cutaneous melanoma (CM) patients present activating BRAF mutations that can be effectively targeted by BRAF inhibitors (BRAFi). However, 20% of CM patients exhibit intrinsic drug resistance to BRAFi, while most of the others develop adaptive resistance over time. The mechanisms involved in BRAFi resistance are disparate and globally seem to rewire the cellular signaling profile by up-regulating different receptor tyrosine kinases (RTKs), such as the epidermal growth factor receptor (EGFR)...
2024: Frontiers in Immunology
https://read.qxmd.com/read/38497423/e3-sumo-ligase-siz1-splicing-variants-localize-and-function-according-to-external-conditions
#15
JOURNAL ARTICLE
Jun Soo Kwak, Jong Tae Song, Hak Soo Seo
SIZ1 (SAP and MIZ1) is a member of the Siz/PIAS-type RING family of E3 SUMO (small ubiquitin-related modifier) ligases that play key roles in growth, development, and stress responses in plant and animal systems. Nevertheless, splicing variants of SIZ1 have not yet been characterized. Here, we identified four splicing variants of Arabidopsis (Arabidopsis thaliana) SIZ1, which encode three different protein isoforms. The SIZ1 gene encodes an 873-amino acid (aa) protein. Among the four SIZ1 splicing variants (SSVs), SSV1 and SSV4 encode identical 885 aa proteins; SSV2 encodes an 832 aa protein; and SSV3 encodes an 884 aa protein...
March 18, 2024: Plant Physiology
https://read.qxmd.com/read/38494438/plasmodesmata-and-intercellular-molecular-traffic-control
#16
REVIEW
Estee E Tee, Christine Faulkner
Plasmodesmata are plasma membrane-lined connections that join plant cells to their neighbours, establishing an intercellular cytoplasmic continuum through which molecules can travel between cells, tissues, and organs. As plasmodesmata connect almost all cells in plants, their molecular traffic carries information and resources across a range of scales, but dynamic control of plasmodesmal aperture can change the possible domains of molecular exchange under different conditions. Plasmodesmal aperture is controlled by specialised signalling cascades accommodated in spatially discrete membrane and cell wall domains...
March 17, 2024: New Phytologist
https://read.qxmd.com/read/38481533/spontaneous-signal-generation-by-an-excitable-system-for-cell-migration
#17
REVIEW
Satomi Matsuoka, Koji Iwamoto, Da Young Shin, Masahiro Ueda
Eukaryotic cells exhibit random migration in the absence of extracellular directional cues. This random migration acts as basal motility for various migratory responses such as chemotaxis. The self-organization of random motility requires the internal signals that determine the anterior side of the migrating cell be generated spontaneously from the intrinsic activities of intracellular signaling networks. Recent studies have identified an excitable system as the mechanism of the spontaneous signal generation...
2024: Frontiers in Cell and Developmental Biology
https://read.qxmd.com/read/38480808/autophagy-as-a-new-player-in-the-regulation-of-clock-neurons-physiology-of-drosophila-melanogaster
#18
JOURNAL ARTICLE
Kornel Szypulski, Aleksandra Tyszka, Elzbieta Pyza, Milena Damulewicz
Axonal terminals of the small ventral lateral neurons (sLNvs), the circadian clock neurons of Drosophila, show daily changes in their arborization complexity, with many branches in the morning and their shrinkage during the night. This complex phenomenon is precisely regulated by several mechanisms. In the present study we describe that one of them is autophagy, a self-degradative process, also involved in changes of cell membrane size and shape. Our results showed that autophagosome formation and processing in PDF-expressing neurons (both sLNv and lLNv) are rhythmic and they have different patterns in the cell bodies and terminals...
March 13, 2024: Scientific Reports
https://read.qxmd.com/read/38479555/comp-promotes-pancreatic-fibrosis-by-activating-pancreatic-stellate-cells-through-cd36-erk-akt-signaling-pathways
#19
JOURNAL ARTICLE
Yi Wang, Hai-Tao Li, Gang Liu, Chuan-Shen Jiang, Yan-Hong Ni, Jing-Hui Zeng, Xia Lin, Qing-Yun Wang, Da-Zhou Li, Wen Wang, Xiang-Peng Zeng
BACKGROUND: Pancreatic fibrosis is one of the most important pathological features of chronic pancreatitis (CP) and pancreatic stellate cells (PSCs) are the key cells of fibrosis. As an extracellular matrix (ECM) glycoprotein, cartilage oligomeric matrix protein (COMP) is critical for collagen assembly and ECM stability and recent studies showed that COMP exert promoting fibrosis effect in the skin, lungs and liver. However, the role of COMP in activation of PSCs and pancreatic fibrosis remain unclear...
March 11, 2024: Cellular Signalling
https://read.qxmd.com/read/38474197/inhibition-of-prmt1-suppresses-the-growth-of-u87mg-derived-glioblastoma-stem-cells-by-blocking-the-stat3-signaling-pathway
#20
JOURNAL ARTICLE
Nayeong Yuk, Hye Jin Jung
Glioblastoma stem cells (GSCs) play a pivotal role in the initiation, progression, resistance to treatment, and relapse of glioblastoma multiforme (GBM). Thus, identifying potential therapeutic targets and drugs that interfere with the growth of GSCs may contribute to improved treatment outcomes for GBM. In this study, we first demonstrated the functional role of protein arginine methyltransferase 1 (PRMT1) in GSC growth. Furamidine, a PRMT1 inhibitor, effectively inhibited the proliferation and tumorsphere formation of U87MG-derived GSCs by inducing cell cycle arrest at the G0/G1 phase and promoting the intrinsic apoptotic pathway...
March 3, 2024: International Journal of Molecular Sciences
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