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Post-bronchiolitis wheezing

Kirsi Nuolivirta, Sari Törmänen, Johanna Teräsjärvi, Juho Vuononvirta, Petri Koponen, Matti Korppi, Merja Helminen, Ville Peltola, Qiushui He
Innate immunity receptors play a critical role in host defence, as well as in allergy and asthma. The aim of this exploratory study was to evaluate whether there are associations between TLR7 rs179008, TLR8 rs2407992, TLR9 rs187084 or TLR10 rs4129009 polymorphisms and viral findings, clinical characteristics or subsequent wheezing in infants with bronchiolitis. In all, 135 full-term infants were hospitalized for bronchiolitis at age less than 6 months: 129 of them were followed-up until the age of 1.5 years...
2016: Scientific Reports
Matti Korppi, Kirsi Nuolivirta, Eero Lauhkonen, Annukka Holster, Johanna Teräsjärvi, Juho Vuononvirta, Merja Helminen, Qiushui He, Petri Koponen
BACKGROUND: Variations in the genes that regulate innate immunity responses may be associated with susceptibility to asthma or atopy after early-life bronchiolitis. The aim of this study was to evaluate the association between four different polymorphisms of the IL-10 gene at rs1800871, rs1800872, rs1800890, and rs1800896, either alone or in combination, and post-bronchiolitis asthma or allergies at 5-7 years of age. METHODS: Data on single nucleotide polymorphisms (SNP) of IL-10 rs1800896 (-1082G/A), rs1800871 (-819C/T), rs1800872 (-592C/A), and IL-10 rs1800890 (-3575T/A) were available for 135 children...
May 26, 2016: Pediatric Pulmonology
Susan Lu, Tina V Hartert, Mark L Everard, Hilde Giezek, Linda Nelsen, Anish Mehta, Hima Patel, Barbara Knorr, Theodore F Reiss
BACKGROUND: We sought to identify predictors of asthma development following severe early childhood RSV bronchiolitis. Different definitions of asthma were also compared. METHODS: This longitudinal, observational study (N = 343) followed patients (<2 years old) from a placebo-controlled trial (N = 979) of montelukast after RSV bronchiolitis to identify clinical, demographic, or biochemical predictors of asthma, atopic disorders, and chronic asthma therapy use at 6 years of age (Clinical Trials Registry Number: NCT01140048)...
May 6, 2016: Pediatric Pulmonology
June Y Y Leung, Hugh S Lam, Gabriel M Leung, C Mary Schooling
BACKGROUND: Preterm birth, early term birth, and low birthweight are associated with childhood wheezing disorders in developed Western settings, but observed associations could be confounded by socio-economic position. This study aims to clarify such associations in a developed non-Western setting with a different confounding structure. METHODS: Using Cox regression, we examined the adjusted associations of gestational age and birthweight for gestational age with time to first public hospital admission for asthma, bronchitis, and bronchiolitis (International Classification of Diseases, Ninth Version Clinical Modification 466, 490, and 493) from 9 days to 12 years in a population-representative birth cohort of 8327 Chinese children in Hong Kong, a developed setting with less clear social patterning of prematurity or birthweight...
March 2016: Paediatric and Perinatal Epidemiology
Eija Bergroth, Matilda Aakula, Matti Korppi, Sami Remes, Juho E Kivistö, Pedro A Piedra, Carlos A Camargo, Tuomas Jartti
BACKGROUND: Our aim was to evaluate the association between viral findings during bronchiolitis and the use of asthma controller medication (primary outcome) and systemic corticosteroids (secondary outcome) during the first post-bronchiolitis year. METHODS: We enrolled 408 children hospitalized for bronchiolitis at <24 months of age in a prospective, 3-center, 1-year follow-up study in Finland. Viruses were detected with polymerase chain reaction in nasopharyngeal aspirates...
April 2016: Pediatric Infectious Disease Journal
Eero Lauhkonen, Petri Koponen, Johanna Teräsjärvi, Kirsi Gröndahl-Yli-Hannuksela, Juho Vuononvirta, Kirsi Nuolivirta, Jyri O Toikka, Merja Helminen, Qiushui He, Matti Korppi
AIM: Interleukin-10 (IL-10) has been associated with wheezing and asthma in children and the genetic variation of the IL-10 cytokine production may be linked to post-bronchiolitis lung function. We used impulse oscillometry (IOS) to evaluate the associations of IL10 polymorphisms with lung function at a median age of 6.3 years in children hospitalised for bronchiolitis before six months of age. METHODS: We performed baseline and post-exercise IOS on 103 former bronchiolitis patients...
2015: PloS One
Luiz Vicente Ribeiro Ferreira da Silva Filho, Leonardo Araujo Pinto, Renato Tetelbom Stein
OBJECTIVE: To review the mechanisms of action of macrolides in pediatric respiratory diseases and their clinical indications. SOURCES: Review in the PubMed database, comprising the following terms in English: "macrolide and asthma"; "macrolide and cystic fibrosis"; "macrolide bronchiolitis and viral acute"; "macrolide and bronchiolitis obliterans" and "macrolide and non-CF bronchiectasis". SUMMARY OF THE FINDINGS: The spectrum of action of macrolides includes production of inflammatory mediators, control of mucus hypersecretion, and modulation of host-defense mechanisms...
November 2015: Jornal de Pediatria
Xueyan Wang, Changshan Liu, Mengjuan Wang, Y I Zhang, Hewen Li, Geli Liu
The aim of the present study was to outline any predisposing factors and clinical and radiological features of post-infectious bronchiolitis obliterans (PIBO) in pediatric patients, and to determine the effect of long-term azithromycin treatment on these factors. In total, 16 cases of children with PIBO were retrospectively reviewed. Adenovirus and Mycoplasma pneumoniae were the most common etiological agents (12/16) in the children with PIBO. The patients presented with persistent dyspnea, a chronic cough, sputum production and wheezing following the initial lung infection...
June 2015: Experimental and Therapeutic Medicine
Paul M Brown, Dana L Schneeberger, Giovanni Piedimonte
Despite fundamental advances in the research on respiratory syncytial virus (RSV) since its initial identification almost 60 years ago, recurring failures in developing vaccines and pharmacologic strategies effective in controlling the infection have allowed RSV to become a leading cause of global infant morbidity and mortality. Indeed, the burden of this infection on families and health care organizations worldwide continues to escalate and its financial costs are growing. Furthermore, strong epidemiologic evidence indicates that early-life lower respiratory tract infections caused by RSV lead to the development of recurrent wheezing and childhood asthma...
September 2015: Paediatric Respiratory Reviews
Na Zang, Simin Li, Wei Li, Xiaohong Xie, Luo Ren, Xiaoru Long, Jun Xie, Yu Deng, Zhou Fu, Fadi Xu, Enmei Liu
Respiratory syncytial virus (RSV) infection is involved in persistent and recurrent wheezing. There are no effective and safe drugs for the sequelae of persistent wheezing after early bronchiolitis. In this study, we investigated the effect of resveratrol on persistent airway inflammation and airway hyperresponsiveness (AHR) induced by RSV infection. RSV-infected mice were sacrificed at serial time points after infection to collect samples and measure the number of inflammatory cells and levels of interferon-gamma (IFN-γ), nerve growth factor (NGF), and brain-derived neurotrophic factor (BDNF)...
September 2015: International Immunopharmacology
Fang Liu, Jing Ouyang, Atul N Sharma, Songqing Liu, Bo Yang, Wei Xiong, Rufu Xu
BACKGROUND: Bronchiolitis is an acute inflammatory illness of the bronchioles common among infants and young children. It is often caused by the respiratory syncytial virus (RSV). Management of bronchiolitis varies between clinicians, reflecting the lack of evidence for a specific treatment approach. The leukotriene pathway has been reported to be involved in the pathogenesis of bronchiolitis. Leukotriene inhibitors such as montelukast have been used in infants and young children with bronchiolitis...
2015: Cochrane Database of Systematic Reviews
Lisiane De Rosa Barbosa, Erissandra Gomes, Gilberto Bueno Fischer
OBJECTIVE: To determine the occurrence of clinical signs of dysphagia in infants with acute viral bronchiolitis, to compare the respiratory parameters during deglutition, and to ensure the intra- and inter- examiners agreement, as well as to accomplish intra and interexaminators concordance of the clinical evaluation of the deglutition. METHODS: This was a cross-sectional study of 42 infants aged 0-12 months. The clinical evaluation was accompanied by measurements of respiratory rate and pulse oximetry...
September 2014: Revista Paulista de Pediatria: Orgão Oficial da Sociedade de Pediatria de São Paulo
Ya-Nan Li, Li Liu, Hong-Mei Qiao, Hang Cheng, Huan-Ji Cheng
BACKGROUND: This study aimed to describe the clinical characteristics, radiological features and outcomes of 42 children with post-infectious bronchiolitis obliterans (PIBO). METHODS: Forty-two children diagnosed with PIBO were prospectively studied at the First Hospital of Jilin University in northern China between January, 2008 and January, 2013. Their clinical characteristics, lung high resolution computed tomography (HRCT) findings and pulmonary function tests were reported...
2014: BMC Pediatrics
Kim Zomer-Kooijker, Cuno S P M Uiterwaal, Anne C van der Gugten, Berry Wilbrink, Louis J Bont, Cornelis K van der Ent
It is unknown why respiratory syncytial virus (RSV) causes mild disease in some children and severe disease, requiring hospitalisation, in others. We aimed to assess whether diminished premorbid lung function in healthy term infants predisposes to hospitalisation during RSV bronchiolitis, and to post-RSV wheeze. In a prospective birth cohort study of unselected term healthy children, neonatal lung function was measured before the age of 2 months (n=2133). From birth through the first year of life, respiratory symptoms were recorded in a diary, and general practitioner consultations and hospitalisations were documented...
September 2014: European Respiratory Journal: Official Journal of the European Society for Clinical Respiratory Physiology
Xiao-Ying Wu, Zheng-Xiu Luo, Zhou Fu, En-Mei Liu, Jian Luo, Ling He
OBJECTIVE: To study the clinical features of bronchiolitis obliterans (BO) in children. METHODS: The clinical data of 28 children with BO between July 2007 and April 2012 was retrospectively reviewed. RESULTS: All patients presented with persistent or repeated cough and wheezing. Twenty-three cases were post-infectious bronchiolitis obliterans (PIBO), among whom the etiology were adenovirus (12 cases), measles (2 cases), influenza virus A (2 cases), mycoplasma pneumoniae (1 case), mycoplasma pneumoniae coinfection with adenovirus (1 case), respiratory syncytial virus coinfection with Parainfluenza type 3 virus (1 case) and pulmonary tuberculosis (1 case)...
October 2013: Zhongguo Dang Dai Er Ke za Zhi, Chinese Journal of Contemporary Pediatrics
Wan-Sheng Peng, Xin Chen, Xiao-Yun Yang, En-Mei Liu
Infants often develop reactive airway diseases subsequent to respiratory syncytial virus (RSV) bronchiolitis. Cysteinyl leukotrienes (cysLTs), a class of lipid mediators that have been implicated in the pathogenesis of allergic rhinitis and asthma, are released during RSV infection, thereby contributing to the pathogenic changes in airway inflammation. Many pediatric patients, especially those of very young age, continue to have recurrent episodes of lower airway obstruction after bronchiolitis treatment. This study was to systematically review and assessed the efficacy of montelukast for preventing wheezing in patients with post-bronchiolitis...
March 2014: Pediatric Allergy and Immunology
Mohammad Reza Etemadi, Norlijah Othman, Carita Savolainen-Kopra, Zamberi Sekawi, NoraAbd Wahab, Lye Munn Sann
BACKGROUND: There is accumulating evidence that human rhinovirus (HRV) causes acute lower respiratory tract infections (ALRTI). Recently, HRV-C was identified as a new species of HRV, but its spectrum of clinical disease is not well understood. OBJECTIVES: We investigated the molecular epidemiology, demographic and clinical characteristics of HRVs among hospitalized children with ALRIs. STUDY DESIGN: One hundred and sixty-five nasopharangeal aspirates taken from children <5 years hospitalized with ALRTIs in Serdang Hospital, Malaysia, were subject to reverse transcriptase-PCR for HRV...
December 2013: Journal of Clinical Virology: the Official Publication of the Pan American Society for Clinical Virology
Carolina Arcanjo Lino, Allyne Kelly M Batista, Maria Aparecida D Soares, Angela Elizabeth H de Freitas, Larissa Calheiros Gomes, José Holanda M Filho, Vivianne Calheiros C Gomes
OBJECTIVES: To describe the clinical and radiological characteristics of patients with bronchiolitis obliterans. METHODS: This is a retrospective and descriptive study. Data were collected from patients diagnosed with bronchiolitis obliterans between 2004 and 2008 in the Pediatric Pulmonology Clinic of Hospital Infantil Albert Sabin, in Ceará, Northeast Brazil. Such diagnosis was based on clinical and tomographic criteria. Previous history, clinical findings at the diagnosis, complementary exams, and follow-up data were evaluated...
January 2013: Revista Paulista de Pediatria: Orgão Oficial da Sociedade de Pediatria de São Paulo
Chang-Keun Kim, Jeong Koo Seo, Seong Hwan Ban, Takao Fujisawa, Dong Won Kim, Zak Callaway
OBJECTIVE: To determine whether eosinophil-derived neurotoxin (EDN) is a predictive marker of recurrent wheezing episodes in post-respiratory syncytial virus (RSV) bronchiolitis. METHODS: EDN levels and recurrent wheezing episodes were serially measured in 200 infants hospitalized with RSV bronchiolitis. RESULTS: Serum EDN levels at 3 months correlated significantly with total wheezing episodes at 12 months in the RSV-PLC (n  = 71; r = 0...
May 2013: Biomarkers: Biochemical Indicators of Exposure, Response, and Susceptibility to Chemicals
Gabrielle B McCallum, Peter S Morris, Anne B Chang
BACKGROUND: Bronchiolitis is a common acute respiratory infectious condition, with a high prevalence worldwide. It is a clinically diagnosed syndrome, manifested by tachypnoea (rapid breathing), with crackles or wheeze in young children. In the acute phase of bronchiolitis (< 14 days), antibiotics have only been recommended when a secondary bacterial infection is suspected. Although bronchiolitis is usually a self-limiting condition, a number of children have persistent respiratory symptoms such as cough and wheezing in post-acute bronchiolitis, and they present or re-present to secondary care...
2012: Cochrane Database of Systematic Reviews
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