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Cerebrolysin

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https://www.readbyqxmd.com/read/28747461/hope-dies-last-evidence-again-fails-to-support-a-neuroprotectant-editorial-on-cerebrolysin-for-acute-ischemic-stroke
#1
EDITORIAL
Daniel Bereczki
No abstract text is available yet for this article.
July 26, 2017: Stroke; a Journal of Cerebral Circulation
https://www.readbyqxmd.com/read/28707130/safety-and-efficacy-of-cerebrolysin-in-motor-function-recovery-after-stroke-a-meta-analysis-of-the-cars-trials
#2
Alla Guekht, Johannes Vester, Wolf-Dieter Heiss, Eugene Gusev, Volker Hoemberg, Volker W Rahlfs, Ovidiu Bajenaru, Bogdan O Popescu, Edith Doppler, Stefan Winter, Herbert Moessler, Dafin Muresanu
This meta-analysis combines the results of two identical stroke studies (CARS-1 and CARS-2) assessing efficacy of Cerebrolysin on motor recovery during early rehabilitation. Cerebrolysin is a parenterally administered neuropeptide preparation approved for the treatment of stroke. Both studies had a prospective, randomized, double-blind, placebo-controlled design. Treatment with 30 ml Cerebrolysin once daily for 3 weeks was started 24-72 h after stroke onset. In addition, patients participated in a standardized rehabilitation program for 21 days that was initiated within 72 h after stroke onset...
July 13, 2017: Neurological Sciences
https://www.readbyqxmd.com/read/28681457/pregnancy-improves-cognitive-deficit-and-neuronal-morphology-atrophy-in-the-prefrontal-cortex-and-hippocampus-of-aging-spontaneously-hypertensive-rats
#3
Verónica R Cabrera-Pedraza, María de Jesús Gómez-Villalobos, Fidel de la Cruz, Patricia Aguilar-Alonso, Sergio Zamudio, Gonzalo Flores
It is well known that the survival is higher in women compared to men and women have a better survival prognosis than men in some pathologies such as vascular dementia (VD). Our previous reports showed that the spontaneously hypertensive (SH) rat, an animal model of VD, exhibited dendritic atrophy of pyramidal neurons of the dorsal hippocampus (DH) and the prefrontal cortex (PFC) at 8 months of age. Cerebrolysin (CBL), a neurotrophic peptide mixture, reduces dendritic atrophy and improves the memory process in aged rats...
July 6, 2017: Synapse
https://www.readbyqxmd.com/read/28656143/efficacy-and-safety-of-cerebrolysin-for-acute-ischemic-stroke-a-meta-analysis-of-randomized-controlled-trials
#4
REVIEW
Danfeng Zhang, Yan Dong, Ya Li, Jigang Chen, Junyu Wang, Lijun Hou
Cerebrolysin was reported to be effective in the neurological improvement of patients with acute ischemic stroke (AIS) in experimental models, while data from clinical trials were inconsistent. We performed a meta-analysis to explore the efficacy and safety of cerebrolysin for AIS. PubMed, EMBASE, and Cochrane Library were searched for randomized controlled trials, which intervened within 72 hours after the stroke onset. We investigated the efficacy and safety outcomes, respectively. Risk ratios and mean differences were pooled with fixed-effects model or random-effects model...
2017: BioMed Research International
https://www.readbyqxmd.com/read/28609577/cerebrolysin-prevents-deficits-in-social-behavior-repetitive-conduct-and-synaptic-inhibition-in-a-rat-model-of-autism
#5
Roberto Cuevas-Olguin, Swagata Roychowdhury, Anwesha Banerjee, Francisco Garcia-Oscos, Eric Esquivel-Rendon, María Elena Bringas, Michael P Kilgard, Gonzalo Flores, Marco Atzori
Autism spectrum disorder (ASD) is a syndrome of diverse neuropsychiatric diseases of growing incidence characterized by repetitive conduct and impaired social behavior and communication for which effective pharmacological treatment is still unavailable. While the mechanisms and etiology of ASD are still unknown, a consensus is emerging about the synaptic nature of the syndrome, suggesting a possible avenue for pharmacological treatment with synaptogenic compounds. The peptidic mixture cerebrolysin (CBL) has been successfully used during the last three decades in the treatment of stroke and neurodegenerative disease...
June 13, 2017: Journal of Neuroscience Research
https://www.readbyqxmd.com/read/28458521/cerebrolysin-for-functional-recovery-in-patients-with-acute-ischemic-stroke-a-meta-analysis-of-randomized-controlled-trials
#6
Zefeng Wang, Ligen Shi, Shenbin Xu, Jianmin Zhang
Cerebrolysin has been shown to have an inconsistent efficacy on functional recovery in patients with acute ischemic stroke (AIS). The present meta-analysis aims to evaluate the value of cerebrolysin and to explore the potential influencing factors. The main electronic databases, including MEDLINE, EMBASE, and the Cochrane Library, were searched. The primary outcome was functional recovery at Day 90. The secondary outcomes included mortality and adverse events. A total of 1,649 patients with AIS were pooled from six randomized controlled trials (RCTs)...
2017: Drug Design, Development and Therapy
https://www.readbyqxmd.com/read/28458021/cerebrolysin-alleviates-cognitive-deficits-induced-by-chronic-cerebral-hypoperfusion-by-increasing-the-levels-of-plasticity-related-proteins-and-decreasing-the-levels-of-apoptosis-related-proteins-in-the-rat-hippocampus
#7
Zhijuan Liu, Ming Hu, Peiyuan Lu, Hebo Wang, Qianqian Qi, Jing Xu, Yining Xiao, Mingyue Fan, Yanqiu Jia, Dandan Zhang
The incidence of vascular dementia (VaD) has rapidly increased over the past few decades. Although officially approved medications for VaD remain limited, cerebrolysin (CBL) had preventive and treatment effects on VaD in some clinical trials. However, the underlying mechanisms have not been determined. The aim of this study was to determine whether CBL protects against cognitive deficits in a rat model of VaD induced by chronic cerebral hypoperfusion by increasing the levels of plasticity-related proteins and decreasing the levels of apoptosis-related proteins...
April 27, 2017: Neuroscience Letters
https://www.readbyqxmd.com/read/28430363/cerebrolysin-for-acute-ischaemic-stroke
#8
REVIEW
Liliya Eugenevna Ziganshina, Tatyana Abakumova, Ludivine Vernay
BACKGROUND: Cerebrolysin is a mixture of low-molecular-weight peptides and amino acids derived from pigs' brain tissue, which has potential neuroprotective and neurotrophic properties. It is widely used in the treatment of acute ischaemic stroke in Russia, Eastern Europe, China, and other Asian and post-Soviet countries. OBJECTIVES: To assess the benefits and risks of cerebrolysin for treating acute ischaemic stroke. SEARCH METHODS: In May 2016 we searched the Cochrane Stroke Group Trials Register, CENTRAL, MEDLINE, Embase, Web of Science Core Collection, with Science Citation Index, LILACS, OpenGrey, and a number of Russian Databases...
April 21, 2017: Cochrane Database of Systematic Reviews
https://www.readbyqxmd.com/read/28382851/demonstration-of-therapeutic-window-of-cerebrolysin-in-embolic-stroke-a-prospective-randomized-blinded-and-placebo-controlled-study
#9
Li Zhang, Michael Chopp, Mei Lu, Talan Zhang, Chao Li, Stefan Winter, Hemma Brandstaetter, Edith Doppler, Dieter Meier, Pardeep Pabla, Zheng G Zhang
Background and aims In an effort to characterize the effects of Cerebrolysin for treatment of stroke that are essential for successful clinical translation, we have demonstrated that Cerebrolysin dose dependently enhanced neurological functional recovery in experimental stroke. Here, we conduct a prospective, randomized, placebo-controlled, blinded study to examine the therapeutic window of Cerebrolysin treatment of rats subjected to embolic stroke. Methods Male Wistar rats age 3-4 months (n = 100) were subjected to embolic middle cerebral artery occlusion...
January 1, 2017: International Journal of Stroke: Official Journal of the International Stroke Society
https://www.readbyqxmd.com/read/28229640/effect-of-cerebrolysin-on-oxidative-stress-induced-apoptosis-in-an-experimental-rat-model-of-myocardial-ischemia
#10
V Boshra, A Atwa
Apoptosis plays a role in the process of tissue damage after myocardial infarction (MI). This study was designed to investigate the possible effect of cerebrolysin against apoptosis triggered by oxidative cell stress in myocardial ischemia induced by isoproterenol in rat. Rats were pretreated with cerebrolysin 5 mL/kg intraperitoneally for 7 days and intoxicated with isoproterenol (ISO, 85 mg/kg, sc) on the last 2 days. Hearts were excised and stained to detect the infarction size. Serum levels of cardiotoxicity indices as creatine kinase isoenzyme (CK-MB) and troponin I (cTnI) as well as the cardiac oxidative stress parameters as thiobarbituric acid reactive substances and superoxide dismutase were estimated...
September 2016: Physiology International
https://www.readbyqxmd.com/read/28131658/cerebrolysin-reduces-mechanical-allodynia-in-a-rodent-model-of-peripheral-inflammation
#11
Julio Cesar Morales-Medina, Natalie H Griffiths, Gonzalo Flores, Virginia M Mastranzo, Tommaso Iannitti
Cerebrolysin (Cbl) is a neuropeptide preparation of cerebroproteins that crosses the blood brain barrier displaying neuroprotective properties and promoting neurogenesis. Limited evidence exists on the efficacy of Cbl for the treatment of pain, with many studies focusing on neuropathic pain associated to diabetes. Therefore, we designed a study to test the hypothesis that Cbl would reduce mechanical allodynia in a rat model of peripheral inflammation induced by administration of complete Freund's adjuvant (CFA) in the hind paw...
March 6, 2017: Neuroscience Letters
https://www.readbyqxmd.com/read/28074392/effect-of-cerebrolysin-on-gross-motor-function-of-children-with-cerebral-palsy-a-clinical-trial
#12
Jafar Nasiri, Faezeh Safavifar
Gross motor dysfunction is considered as the most challenging problem in cerebral palsy (CP). It is proven that improvement of gross motor function could reduce CP-related disabilities and provide better quality of life in this group of patients. Therefore, the aim of this trial is to evaluate the effectiveness of cerebrolysin (CBL) on gross motor function of children with CP who are undergoing treatment. In this clinical trial study, paediatric patients aged 18-75 months with spastic diplegic or quadriplegic cerebral palsy, who were under rehabilitation therapy, were selected and randomly allocated in control and CBL groups...
January 10, 2017: Acta Neurologica Belgica
https://www.readbyqxmd.com/read/27918088/cerebrolysin-for-acute-ischaemic-stroke
#13
REVIEW
Liliya Eugenevna Ziganshina, Tatyana Abakumova, Ludivine Vernay
BACKGROUND: Cerebrolysin is a mixture of low-molecular-weight peptides and amino acids derived from pigs' brain tissue, which has potential neuroprotective and neurotrophic properties. It is widely used in the treatment of acute ischaemic stroke in Russia, Eastern Europe, China, and other Asian and post-Soviet countries. OBJECTIVES: To assess the benefits and risks of cerebrolysin for treating acute ischaemic stroke. SEARCH METHODS: In May 2016 we searched the Cochrane Stroke Group Trials Register, CENTRAL, MEDLINE, Embase, Web of Science Core Collection, with Science Citation Index, LILACS, OpenGrey, and a number of Russian Databases...
December 5, 2016: Cochrane Database of Systematic Reviews
https://www.readbyqxmd.com/read/27894939/intranasal-cerebrolysin-attenuates-learning-and-memory-impairments-in-d-galactose-induced-senescence-in-mice
#14
Ehsan Pourmemar, Alireza Majdi, Morteza Haramshahi, Mahnaz Talebi, Pouran Karimi, Saeed Sadigh-Eteghad
Neurotrophic factors are currently being considered as pro-cognitive therapeutic approaches for management of cognitive deficits. This study aims to evaluate the effects of intranasal (i.n.) or intraperitoneal (i.p.) administration of Cerebrolysin (CBL) (as a mixture of neurotrophic factors) on the d-galactose-induced oxidative stress, apoptosis and memory as well as learning impairment in mice. For this purpose, CBL (1, 2.5, 5 ml/kg/i.p.) or (1 ml/kg/i.n.), were administrated daily in d-galactose-received (100 mg/kg/subcutaneous (s...
January 2017: Experimental Gerontology
https://www.readbyqxmd.com/read/27871029/effects-of-cerebrolysin-on-functional-recovery-in-patients-with-severe-disability-after-traumatic-brain-injury-a-historical-cohort-study
#15
Hosseinali Khalili, Amin Niakan, Fariborz Ghaffarpasand
OBJECTIVE: To determine the effects of cerebrolysin on functional recovery in patients with severe disability after traumatic brain injury (TBI). METHODS: This was a retrospective cohort study being performed during a 2-year period in a level I trauma center in Southern Iran including all the adult patients (>16years) with severe disability (GOS of 2 and 3) 1-month after trauma. We excluded those with posttraumatic seizures and those with meningitis or current infections...
January 2017: Clinical Neurology and Neurosurgery
https://www.readbyqxmd.com/read/27845323/-clinical-and-neurophysiological-heterogeneity-of-attention-deficit-hyperactivity-disorder
#16
L S Chutko, E A Yakovenko, S Yu Surushkina, T I Anisimova, Yu D Kropotov
AIM: To determine clinical/neurophysiological characteristics of different forms of attention deficit hyperactivity disorder (ADHD) and the efficacy of treatment with cerebrolysin. MATERIAL AND METHODS: Sixty children, aged 9 to 12 years, with ADHD were examined using clinical and electroencephalographic methods. Idiopathic and residual-organic forms were compared. RESULTS AND CONCLUSION: The study shows significantly higher levels of impulsivity and hyperactivity in children with residual-organic form of the disease...
2016: Zhurnal Nevrologii i Psikhiatrii Imeni S.S. Korsakova
https://www.readbyqxmd.com/read/27827552/alzheimer-s-disease-cerebrolysin-and-nanotechnology-as-a-therapeutic-strategy
#17
Hari S Sharma, Dafin F Muresanu, Aruna Sharma
No abstract text is available yet for this article.
November 9, 2016: Neurodegenerative Disease Management
https://www.readbyqxmd.com/read/27539610/a-meta-analysis-of-the-effect-of-different-neuroprotective-drugs-in-management-of-patients-with-traumatic-brain-injury
#18
REVIEW
Iman El Sayed, Adel Zaki, Akram M Fayed, Gihan M Shehata, Sherif Abdelmonem
Traumatic brain injury is a major problem worldwide. Our objective is to synthesize available evidence in the literature concerning the effectiveness of neuroprotective drugs (cerebrolysin, citicoline, and piracetam) on Glasgow outcome score (GOS), cognitive performance, and survival in traumatic brain injury patients. Comprehensive search of electronic databases, search engines, and conferences proceedings; hand search journals; searching reference lists of relevant articles, theses, and local publications; and contact of authors for incomplete data were performed...
August 18, 2016: Neurosurgical Review
https://www.readbyqxmd.com/read/27429559/neuropeptide-treatment-with-cerebrolysin-enhances-the-survival-of-grafted-neural-stem-cell-in-an-%C3%AE-synuclein-transgenic-model-of-parkinson-s-disease
#19
Edward Rockenstein, Paula Desplats, Kiren Ubhi, Michael Mante, Jazmin Florio, Anthony Adame, Stefan Winter, Hemma Brandstaetter, Dieter Meier, Herbert Moessler, Eliezer Masliah
Neuronal stem cell (NSC) grafts have been investigated as a potential neuro-restorative therapy in Parkinson's disease (PD) but their use is compromised by the death of grafted cells. We investigated the use of Cerebrolysin (CBL), a neurotrophic peptide mixture, as an adjunct to NSC therapy in the α-synuclein (α-syn) transgenic (tg) model of PD. In vehicle-treated α-syn tg mice, there was decreased survival of NSCs. In contrast, CBL treatment enhanced the survival of NSCs in α-syn tg groups and ameliorated behavioral deficits...
2015: Journal of Experimental Neuroscience
https://www.readbyqxmd.com/read/27383892/effect-of-cerebrolysin-on-dopaminergic-neurodegeneration-of-rat-with-oxidative-stress-induced-by-3-nitropropionic-acid
#20
David Calderón Guzmán, Norma Osnaya Brizuela, Maribel Ortíz Herrera, Ernestina Hernández García, Gerardo Barragán Mejía, Hugo Juárez Olguín, Armando Valenzuela Peraza, Jonas Attilus, Norma Labra Ruíz
The study tested the hypothesis that cerebrolysin protects the brain from free radicals in rats treated with 3-nitropropionic acid (3-NPA). To address this hypothesis, the levels of dopamine (DA) and some oxidative stress biomarkers were measured after administration of 3-NPA. Young male Fischer rats were treated for three days with cerebrolysin, 3-NPA or both substances. Their brains were extracted, and DA, lipid peroxidation (LP), glutathione (GSH), calcium, and H2O2 were measured using validated methods...
September 1, 2016: Acta Pharmaceutica
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