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Cerebrolysin

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https://www.readbyqxmd.com/read/29142564/clinical-effects-of-ganglioside-and-fructose-1-6-diphosphate-on-neonatal-heart-and-brain-injuries-after-asphyxia
#1
Xiaojing Zhu, Hongya Li, Congmin Zhang
Objective: To study the clinical effect of ganglioside (GM) and fructose-1, 6-diphosphate (FDP) on neonatal heart and brain injuries after asphyxia. Methods: Ninety-one neonates with asphyxia neonatal heart and brain injuries were randomly divided into an observation group and a control group. Both groups were given symptomatic treatment as soon as possible. On this basis, the observation group was given 200 mL of 5% glucose injection and 20 mg of GM and 250 mg/kg·d FDP by intravenous infusion...
September 2017: Pakistan Journal of Medical Sciences Quarterly
https://www.readbyqxmd.com/read/29132543/intravenous-administration-of-functionalized-magnetic-iron-oxide-nanoparticles-does-not-induce-cns-injury-in-the-rat-influence-of-spinal-cord-trauma-and-cerebrolysin-treatment
#2
Preeti K Menon, Aruna Sharma, José V Lafuente, Dafin F Muresanu, Zoraida P Aguilar, Y Anderw Wang, Ranjana Patnaik, Herbert Mössler, Hari S Sharma
Influence of iron oxide magnetic nanoparticles (IOMNPs, 10nm in diameter, 0.25 or 0.50mg/mL in 100μL, i.v.) on the blood-brain barrier (BBB) permeability, edema formation, and neuronal or glial changes within 4-24h after administration was examined in normal rats and after a focal spinal cord injury (SCI). Furthermore, effect of cerebrolysin, a balanced composition of several neurotrophic factors, and active peptide fragments was also evaluated on IOMNP-induced changes in central nervous system (CNS) pathology...
2017: International Review of Neurobiology
https://www.readbyqxmd.com/read/29132541/novel-treatment-strategies-using-tio2-nanowired-delivery-of-histaminergic-drugs-and-antibodies-to-tau-with-cerebrolysin-for-superior-neuroprotection-in-the-pathophysiology-of-alzheimer-s-disease
#3
Aruna Sharma, Preeti K Menon, Ranjana Patnaik, Dafin F Muresanu, José V Lafuente, Z Ryan Tian, Asya Ozkizilcik, Rudy J Castellani, Herbert Mössler, Hari S Sharma
More than 5.5 million Americans of all ages are suffering from Alzheimer's disease (AD) till today for which no suitable therapy has been developed so far. Thus, there is an urgent need to explore novel therapeutic measures to contain brain pathology in AD. The hallmark of AD includes amyloid-beta peptide (AβP) deposition and phosphorylation of tau in AD brain. Recent evidences also suggest a marked decrease in neurotrophic factors in AD. Thus, exogenous supplement of neurotrophic factors could be one of the possible ways for AD therapy...
2017: International Review of Neurobiology
https://www.readbyqxmd.com/read/29107328/effect-of-cerebrolysin-on-the-cerebellum-of-diabetic-rats-an-imunohistochemical-study
#4
Rania N Sherif
BACKGROUND: Diabetes mellitus represents one of the disorders in the metabolism that affects all body systems including CNS. Cerebrolysin contains many neurotrophic factors, and many studies reported that it can be used treatment of many neurological disorders. AIM OF THE WORK: The aim of the current study was to study the potential neuroprotective effect of cerebrolysin on the cerebellum of diabetic rat. MATERIALS AND METHODS: Sprague Dawley male rats were divided randomly into four groups: control, cerebrolysin (Cbl), diabetes and diabetes treated with Cbl groups...
October 25, 2017: Tissue & Cell
https://www.readbyqxmd.com/read/29075344/efficacy-of-cerebrolysin-in-the-reduction-of-spasticity-during-stroke-rehabilitation
#5
R M Martinez
AIM: This study assessed the efficacy of Cerebrolysin on post-stroke spasticity, motor recovery, and global functions in an outpatient rehabilitation setting. METHODS: In this retrospective comparison study, Cerebrolysin was administered at a daily dosage of 10 ml for over 30 days as an intramuscular injection. Control patients did not receive Cerebrolysin. All the patients participated in a standardized physical and occupational rehabilitation therapy for one month at least two times per week...
July 2017: Journal of Medicine and Life
https://www.readbyqxmd.com/read/29075343/efficacy-and-safety-of-cerebrolysin-treatment-in-early-recovery-after-acute-ischemic-stroke-a-randomized-placebo-controlled-double-blinded-multicenter-clinical-trial
#6
K Gharagozli, A A Harandi, S Houshmand, N Akbari, D F Muresanu, J Vester, S Winter, H Moessler
Background and Purpose : The aim of this study was to evaluate the efficacy, safety, and tolerability of cerebrolysin in the early recovery phase after acute ischemic stroke. Methods. This prospective, randomized, double-blinded, placebo-controlled, multicenter, parallel-group study enrolled a total of 100 patients within 18 h after the onset of stroke. The patients were treated with Cerebrolysin (30 mL over seven days followed by 10 mL until day 30) or placebo once daily over a period of four weeks. Efficacy was primarily assessed by the NIH Stroke Scale at day 30, and additional parameters included the modified Rankin Scale, the Clinical Global Impression, the Patient Global Satisfaction (PGS) and the Mini Mental State Examination (MMSE)...
July 2017: Journal of Medicine and Life
https://www.readbyqxmd.com/read/29053124/-the-efficacy-of-cerebrolysin-in-the-treatment-of-autism-spectrum-disorders
#7
L S Chutko, E A Yakovenko, S Yu Surushkina, E M Kryukova, S V Palaieva
AIM: To evaluate clinical and neurophysiological changes in children with different variants of autism spectrum disorders during treatment with cerebrolysin. MATERIAL AND METHODS: Forty-three children with autism spectrum disorders, aged 4-6 years, were included in the study. To assess the degree of autism, the quantitative scale of assessing the severity of child autism CARS ('Childhood Autism Rating Scale') was used. A comparative analysis of the clinical picture of disease and data of the electroencephalographic examination in endogenous and exogenous (organic) variant of autism was made...
2017: Zhurnal Nevrologii i Psikhiatrii Imeni S.S. Korsakova
https://www.readbyqxmd.com/read/28884714/-therapeutic-monitoring-and-prediction-of-the-efficacy-of-neurotrophic-treatment-in-patients-with-amnestic-type-of-mild-cognitive-impairment
#8
S I Gavrilova, O M Volpina, I V Kolykhalov, Ya B Fedorova, N D Selezneva, E V Ponomareva, D O Koroev, A V Kamynina
AIM: To perform therapeutic monitoring and prediction of the neurotrophic therapy efficacy in patients with amnestic type of mild cognitive impairment (aMCI) in a model of course cerebrolysin therapy. MATERIAL AND METHODS: The study involved a group of 19 elderly patients who met the diagnostic criteria of aMCI. All patients received a course of neurotrophic therapy consisting of 20 intravenous infusions of cerebrolysin (30 ml of cerebrolysin in 100 ml of isotonic sodium chloride solution)...
2017: Zhurnal Nevrologii i Psikhiatrii Imeni S.S. Korsakova
https://www.readbyqxmd.com/read/28875428/timed-release-of-cerebrolysin-using-drug-loaded-titanate-nanospheres-reduces-brain-pathology-and-improves-behavioral-functions-in-parkinson-s-disease
#9
Asya Ozkizilcik, Aruna Sharma, Dafin F Muresanu, José V Lafuente, Z Ryan Tian, Ranjana Patnaik, Herbert Mössler, Hari S Sharma
Previous studies from our laboratory show that intraperitoneal injections of 1-metyl-4-phenyl-1,2,3,6-tetrahydropyridin (MPTP, 20 mg/kg) daily within 2-h intervals for 5 days in mice induce Parkinson's disease (PD)-like symptoms on the 8th day. A significant decrease in dopamine (DA) and its metabolites 3,4-dihydroxyphenylacetic acid (DOPAC) and homovanillic acid (HVA) along with a marked decrease in the number of tyrosine hydroxylase (TH)-positive cells in the substantia nigra pars compacta (SNpc) and striatum (STr) confirms the validity of this model for studying PD...
September 5, 2017: Molecular Neurobiology
https://www.readbyqxmd.com/read/28847022/attenuation-of-morphine-induced-tolerance-and-dependence-by-pretreatment-with-cerebrolysin-in-male-rats
#10
Hamed Ghavimi, Sara Darvishi, Saeed Ghanbarzadeh
Background Dependence and tolerance to morphine are major problems which limit its chronic clinical application. Purpose This study was aimed to investigate the attenuation effect of Cerebrolysin, a mixture of potent growth factors (BDNF, GDNF, NGF, CNTF etc,), on the development of Morphine-induced dependence and tolerance. Methods Male Wistar rats were selected randomly and divided into different groups (n=8) including: a control group, groups received additive doses of morphine (5-25 mg/kg, ip, at an interval of 12 h until tolerance completion), and groups pretreated with Cerebrolysin (40, 80 and 160 mg/kg, ip, before morphine administration)...
August 28, 2017: Drug Research
https://www.readbyqxmd.com/read/28844104/co-administration-of-tio2-nanowired-mesenchymal-stem-cells-with-cerebrolysin-potentiates-neprilysin-level-and-reduces-brain-pathology-in-alzheimer-s-disease
#11
Hari Shanker Sharma, Dafin Fior Muresanu, José Vicente Lafuente, Ranjana Patnaik, Z Ryan Tian, Asya Ozkizilcik, Rudy J Castellani, Herbert Mössler, Aruna Sharma
Neprilysin (NPL), the rate-limiting enzyme for amyloid beta peptide (AβP), appears to play a crucial role in the pathogenesis of Alzheimer's disease (AD). Since mesenchymal stem cells (MSCs) and/or cerebrolysin (CBL, a combination of neurotrophic factors and active peptide fragments) have neuroprotective effects in various CNS disorders, we examined nanowired delivery of MSCs and CBL on NPL content and brain pathology in AD using a rat model. AD-like symptoms were produced by intraventricular (i.c.v.) administration of AβP (1-40) in the left lateral ventricle (250 ng/10 μl, once daily) for 4 weeks...
August 26, 2017: Molecular Neurobiology
https://www.readbyqxmd.com/read/28840482/nanodelivery-of-cerebrolysin-and-rearing-in-enriched-environment-induce-neuroprotective-effects-in-a-preclinical-rat-model-of-parkinson-s-disease
#12
C Requejo, J A Ruiz-Ortega, H Cepeda, A Sharma, H S Sharma, A Ozkizilcik, R Tian, H Moessler, L Ugedo, J V Lafuente
Rearing in enriched environment (EE) improves the recuperation in animal models of Parkinson's disease (PD). Administration of TiO2-nanowired cerebrolysin (CBL) could represent an additional strategy to protect or repair the nigrostriatal system. This study aims to explore morphofunctional and biochemical changes in a preclinical stage of PD testing the synergistic efficiency of combining both strategies, housing in EE, and nanodelivery of CBL. Sprague-Dawley male rats receiving intrastriatally 6-hydroxydopamine after a short evolution time were segregated into CBL group (rats receiving nanowired CBL), EE group (rats housed in EE), CBL + EE group (rats housed in EE and receiving nanowired CBL), and control group (rats without additional treatment)...
August 24, 2017: Molecular Neurobiology
https://www.readbyqxmd.com/read/28747461/hope-dies-last-evidence-again-fails-to-support-a-neuroprotectant-editorial-on-cerebrolysin-for-acute-ischemic-stroke
#13
EDITORIAL
Daniel Bereczki
No abstract text is available yet for this article.
July 26, 2017: Stroke; a Journal of Cerebral Circulation
https://www.readbyqxmd.com/read/28707130/safety-and-efficacy-of-cerebrolysin-in-motor-function-recovery-after-stroke-a-meta-analysis-of-the-cars-trials
#14
Alla Guekht, Johannes Vester, Wolf-Dieter Heiss, Eugene Gusev, Volker Hoemberg, Volker W Rahlfs, Ovidiu Bajenaru, Bogdan O Popescu, Edith Doppler, Stefan Winter, Herbert Moessler, Dafin Muresanu
This meta-analysis combines the results of two identical stroke studies (CARS-1 and CARS-2) assessing efficacy of Cerebrolysin on motor recovery during early rehabilitation. Cerebrolysin is a parenterally administered neuropeptide preparation approved for the treatment of stroke. Both studies had a prospective, randomized, double-blind, placebo-controlled design. Treatment with 30 ml Cerebrolysin once daily for 3 weeks was started 24-72 h after stroke onset. In addition, patients participated in a standardized rehabilitation program for 21 days that was initiated within 72 h after stroke onset...
July 13, 2017: Neurological Sciences
https://www.readbyqxmd.com/read/28681457/pregnancy-improves-cognitive-deficit-and-neuronal-morphology-atrophy-in-the-prefrontal-cortex-and-hippocampus-of-aging-spontaneously-hypertensive-rats
#15
Verónica R Cabrera-Pedraza, María de Jesús Gómez-Villalobos, Fidel de la Cruz, Patricia Aguilar-Alonso, Sergio Zamudio, Gonzalo Flores
It is well known that the survival is higher in women compared to men and women have a better survival prognosis than men in some pathologies such as vascular dementia (VD). Our previous reports showed that the spontaneously hypertensive (SH) rat, an animal model of VD, exhibited dendritic atrophy of pyramidal neurons of the dorsal hippocampus (DH) and the prefrontal cortex (PFC) at 8 months of age. Cerebrolysin (CBL), a neurotrophic peptide mixture, reduces dendritic atrophy and improves the memory process in aged rats...
July 6, 2017: Synapse
https://www.readbyqxmd.com/read/28656143/efficacy-and-safety-of-cerebrolysin-for-acute-ischemic-stroke-a-meta-analysis-of-randomized-controlled-trials
#16
REVIEW
Danfeng Zhang, Yan Dong, Ya Li, Jigang Chen, Junyu Wang, Lijun Hou
Cerebrolysin was reported to be effective in the neurological improvement of patients with acute ischemic stroke (AIS) in experimental models, while data from clinical trials were inconsistent. We performed a meta-analysis to explore the efficacy and safety of cerebrolysin for AIS. PubMed, EMBASE, and Cochrane Library were searched for randomized controlled trials, which intervened within 72 hours after the stroke onset. We investigated the efficacy and safety outcomes, respectively. Risk ratios and mean differences were pooled with fixed-effects model or random-effects model...
2017: BioMed Research International
https://www.readbyqxmd.com/read/28609577/cerebrolysin-prevents-deficits-in-social-behavior-repetitive-conduct-and-synaptic-inhibition-in-a-rat-model-of-autism
#17
Roberto Cuevas-Olguin, Swagata Roychowdhury, Anwesha Banerjee, Francisco Garcia-Oscos, Eric Esquivel-Rendon, María Elena Bringas, Michael P Kilgard, Gonzalo Flores, Marco Atzori
Autism spectrum disorder (ASD) is a syndrome of diverse neuropsychiatric diseases of growing incidence characterized by repetitive conduct and impaired social behavior and communication for which effective pharmacological treatment is still unavailable. While the mechanisms and etiology of ASD are still unknown, a consensus is emerging about the synaptic nature of the syndrome, suggesting a possible avenue for pharmacological treatment with synaptogenic compounds. The peptidic mixture cerebrolysin (CBL) has been successfully used during the last three decades in the treatment of stroke and neurodegenerative disease...
June 13, 2017: Journal of Neuroscience Research
https://www.readbyqxmd.com/read/28458521/cerebrolysin-for-functional-recovery-in-patients-with-acute-ischemic-stroke-a-meta-analysis-of-randomized-controlled-trials
#18
Zefeng Wang, Ligen Shi, Shenbin Xu, Jianmin Zhang
Cerebrolysin has been shown to have an inconsistent efficacy on functional recovery in patients with acute ischemic stroke (AIS). The present meta-analysis aims to evaluate the value of cerebrolysin and to explore the potential influencing factors. The main electronic databases, including MEDLINE, EMBASE, and the Cochrane Library, were searched. The primary outcome was functional recovery at Day 90. The secondary outcomes included mortality and adverse events. A total of 1,649 patients with AIS were pooled from six randomized controlled trials (RCTs)...
2017: Drug Design, Development and Therapy
https://www.readbyqxmd.com/read/28458021/cerebrolysin-alleviates-cognitive-deficits-induced-by-chronic-cerebral-hypoperfusion-by-increasing-the-levels-of-plasticity-related-proteins-and-decreasing-the-levels-of-apoptosis-related-proteins-in-the-rat-hippocampus
#19
Zhijuan Liu, Ming Hu, Peiyuan Lu, Hebo Wang, Qianqian Qi, Jing Xu, Yining Xiao, Mingyue Fan, Yanqiu Jia, Dandan Zhang
The incidence of vascular dementia (VaD) has rapidly increased over the past few decades. Although officially approved medications for VaD remain limited, cerebrolysin (CBL) had preventive and treatment effects on VaD in some clinical trials. However, the underlying mechanisms have not been determined. The aim of this study was to determine whether CBL protects against cognitive deficits in a rat model of VaD induced by chronic cerebral hypoperfusion by increasing the levels of plasticity-related proteins and decreasing the levels of apoptosis-related proteins...
April 27, 2017: Neuroscience Letters
https://www.readbyqxmd.com/read/28430363/cerebrolysin-for-acute-ischaemic-stroke
#20
REVIEW
Liliya Eugenevna Ziganshina, Tatyana Abakumova, Ludivine Vernay
BACKGROUND: Cerebrolysin is a mixture of low-molecular-weight peptides and amino acids derived from pigs' brain tissue, which has potential neuroprotective and neurotrophic properties. It is widely used in the treatment of acute ischaemic stroke in Russia, Eastern Europe, China, and other Asian and post-Soviet countries. OBJECTIVES: To assess the benefits and risks of cerebrolysin for treating acute ischaemic stroke. SEARCH METHODS: In May 2016 we searched the Cochrane Stroke Group Trials Register, CENTRAL, MEDLINE, Embase, Web of Science Core Collection, with Science Citation Index, LILACS, OpenGrey, and a number of Russian Databases...
April 21, 2017: Cochrane Database of Systematic Reviews
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