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V Boshra, A Atwa
Apoptosis plays a role in the process of tissue damage after myocardial infarction (MI). This study was designed to investigate the possible effect of cerebrolysin against apoptosis triggered by oxidative cell stress in myocardial ischemia induced by isoproterenol in rat. Rats were pretreated with cerebrolysin 5 mL/kg intraperitoneally for 7 days and intoxicated with isoproterenol (ISO, 85 mg/kg, sc) on the last 2 days. Hearts were excised and stained to detect the infarction size. Serum levels of cardiotoxicity indices as creatine kinase isoenzyme (CK-MB) and troponin I (cTnI) as well as the cardiac oxidative stress parameters as thiobarbituric acid reactive substances and superoxide dismutase were estimated...
September 2016: Physiol Int
Julio Cesar Morales-Medina, Natalie H Griffiths, Gonzalo Flores, Virginia M Mastranzo, Tommaso Iannitti
Cerebrolysin (Cbl) is a neuropeptide preparation of cerebroproteins that crosses the blood brain barrier displaying neuroprotective properties and promoting neurogenesis. Limited evidence exists on the efficacy of Cbl for the treatment of pain, with many studies focusing on neuropathic pain associated to diabetes. Therefore, we designed a study to test the hypothesis that Cbl would reduce mechanical allodynia in a rat model of peripheral inflammation induced by administration of complete Freund's adjuvant (CFA) in the hind paw...
March 6, 2017: Neuroscience Letters
Jafar Nasiri, Faezeh Safavifar
Gross motor dysfunction is considered as the most challenging problem in cerebral palsy (CP). It is proven that improvement of gross motor function could reduce CP-related disabilities and provide better quality of life in this group of patients. Therefore, the aim of this trial is to evaluate the effectiveness of cerebrolysin (CBL) on gross motor function of children with CP who are undergoing treatment. In this clinical trial study, paediatric patients aged 18-75 months with spastic diplegic or quadriplegic cerebral palsy, who were under rehabilitation therapy, were selected and randomly allocated in control and CBL groups...
January 10, 2017: Acta Neurologica Belgica
Liliya Eugenevna Ziganshina, Tatyana Abakumova, Ludivine Vernay
BACKGROUND: Cerebrolysin is a mixture of low-molecular-weight peptides and amino acids derived from pigs' brain tissue, which has potential neuroprotective and neurotrophic properties. It is widely used in the treatment of acute ischaemic stroke in Russia, Eastern Europe, China, and other Asian and post-Soviet countries. OBJECTIVES: To assess the benefits and risks of cerebrolysin for treating acute ischaemic stroke. SEARCH METHODS: In May 2016 we searched the Cochrane Stroke Group Trials Register, CENTRAL, MEDLINE, Embase, Web of Science Core Collection, with Science Citation Index, LILACS, OpenGrey, and a number of Russian Databases...
December 5, 2016: Cochrane Database of Systematic Reviews
Ehsan Pourmemar, Alireza Majdi, Morteza Haramshahi, Mahnaz Talebi, Pouran Karimi, Saeed Sadigh-Eteghad
Neurotrophic factors are currently being considered as pro-cognitive therapeutic approaches for management of cognitive deficits. This study aims to evaluate the effects of intranasal (i.n.) or intraperitoneal (i.p.) administration of Cerebrolysin (CBL) (as a mixture of neurotrophic factors) on the d-galactose-induced oxidative stress, apoptosis and memory as well as learning impairment in mice. For this purpose, CBL (1, 2.5, 5 ml/kg/i.p.) or (1 ml/kg/i.n.), were administrated daily in d-galactose-received (100 mg/kg/subcutaneous (s...
January 2017: Experimental Gerontology
Hosseinali Khalili, Amin Niakan, Fariborz Ghaffarpasand
OBJECTIVE: To determine the effects of cerebrolysin on functional recovery in patients with severe disability after traumatic brain injury (TBI). METHODS: This was a retrospective cohort study being performed during a 2-year period in a level I trauma center in Southern Iran including all the adult patients (>16years) with severe disability (GOS of 2 and 3) 1-month after trauma. We excluded those with posttraumatic seizures and those with meningitis or current infections...
January 2017: Clinical Neurology and Neurosurgery
L S Chutko, E A Yakovenko, S Yu Surushkina, T I Anisimova, Yu D Kropotov
AIM: To determine clinical/neurophysiological characteristics of different forms of attention deficit hyperactivity disorder (ADHD) and the efficacy of treatment with cerebrolysin. MATERIAL AND METHODS: Sixty children, aged 9 to 12 years, with ADHD were examined using clinical and electroencephalographic methods. Idiopathic and residual-organic forms were compared. RESULTS AND CONCLUSION: The study shows significantly higher levels of impulsivity and hyperactivity in children with residual-organic form of the disease...
2016: Zhurnal Nevrologii i Psikhiatrii Imeni S.S. Korsakova
Hari S Sharma, Dafin F Muresanu, Aruna Sharma
No abstract text is available yet for this article.
November 9, 2016: Neurodegenerative Disease Management
Iman El Sayed, Adel Zaki, Akram M Fayed, Gihan M Shehata, Sherif Abdelmonem
Traumatic brain injury is a major problem worldwide. Our objective is to synthesize available evidence in the literature concerning the effectiveness of neuroprotective drugs (cerebrolysin, citicoline, and piracetam) on Glasgow outcome score (GOS), cognitive performance, and survival in traumatic brain injury patients. Comprehensive search of electronic databases, search engines, and conferences proceedings; hand search journals; searching reference lists of relevant articles, theses, and local publications; and contact of authors for incomplete data were performed...
August 18, 2016: Neurosurgical Review
Edward Rockenstein, Paula Desplats, Kiren Ubhi, Michael Mante, Jazmin Florio, Anthony Adame, Stefan Winter, Hemma Brandstaetter, Dieter Meier, Herbert Moessler, Eliezer Masliah
Neuronal stem cell (NSC) grafts have been investigated as a potential neuro-restorative therapy in Parkinson's disease (PD) but their use is compromised by the death of grafted cells. We investigated the use of Cerebrolysin (CBL), a neurotrophic peptide mixture, as an adjunct to NSC therapy in the α-synuclein (α-syn) transgenic (tg) model of PD. In vehicle-treated α-syn tg mice, there was decreased survival of NSCs. In contrast, CBL treatment enhanced the survival of NSCs in α-syn tg groups and ameliorated behavioral deficits...
2015: Journal of Experimental Neuroscience
David Calderón Guzmán, Norma Osnaya Brizuela, Maribel Ortíz Herrera, Ernestina Hernández García, Gerardo Barragán Mejía, Hugo Juárez Olguín, Armando Valenzuela Peraza, Jonas Attilus, Norma Labra Ruíz
The study tested the hypothesis that cerebrolysin protects the brain from free radicals in rats treated with 3-nitropropionic acid (3-NPA). To address this hypothesis, the levels of dopamine (DA) and some oxidative stress biomarkers were measured after administration of 3-NPA. Young male Fischer rats were treated for three days with cerebrolysin, 3-NPA or both substances. Their brains were extracted, and DA, lipid peroxidation (LP), glutathione (GSH), calcium, and H2O2 were measured using validated methods...
September 1, 2016: Acta Pharmaceutica
S V Berezhnaya, E Z Yakupov, Yu A Zakharov
OBJECTIVE: To study the impact of combination therapy with mexidol and cerebrolysin on the clinical status of patients with chronic cerebral ischemia (CCI), II stage, in ambulatory conditions. MATERIAL AND METHODS: The study included 36 patients with CCI, II stage. In addition to basic therapy, patients received two courses of the mexidol/cerebrolysin combination during 6 weeks with 3 month-interval between the courses. The dynamics of subjective complaints of the patients and objective clinical signs was assessed after each course...
2016: Zhurnal Nevrologii i Psikhiatrii Imeni S.S. Korsakova
Neveen A Noor, Haitham S Mohammed, Iman M Mourad, Yasser A Khadrawy, Heba S Aboul Ezz
AIMS: Parkinson's disease (PD) is the second most prevalent neurodegenerative disease affecting the population. The present study investigates the potential therapeutic effect of cerebrolysin (CBL), as a neurotrophic factor mimic, on the behavioral and biochemical alterations induced in 6-hydroxydopamine (6-OHDA) - lesioned rats as a model of PD. MAIN METHODS: The animals were divided into 3 experimental groups; control group, Parkinsonian model group through bilateral microinjection of 6-OHDA into substantia nigra (SN) and CBL-treated group which received a daily intraperitoneal administration of CBL (2...
June 15, 2016: Life Sciences
X Anton Alvarez, Irene Alvarez, Olalla Iglesias, Ignacio Crespo, Jesus Figueroa, Manuel Aleixandre, Carlos Linares, Elias Granizo, Manuel Garcia-Fantini, Jose Marey, Eliezer Masliah, Stefan Winter, Dafin Muresanu, Herbert Moessler
BACKGROUND: Low circulating brain derived neurotrophic factor may promote cognitive deterioration, but the effects of neurotrophic and combination drug therapies on serum brain derived neurotrophic factor were not previously investigated in Alzheimer's disease. METHODS: We evaluated the effects of Cerebrolysin, donepezil, and the combined therapy on brain derived neurotrophic factor serum levels at week 16 (end of Cerebrolysin treatment) and week 28 (endpoint) in mild-to-moderate Alzheimer's disease patients...
April 7, 2016: International Journal of Neuropsychopharmacology
Li-Xia Xue, Ting Zhang, Yu-Wu Zhao, Zhi Geng, Jing-Jiong Chen, Hao Chen
Cerebrolysin and DL-3-n-butylphthalide (NBP) have each shown neuroprotective efficacy in preclinical models of acute ischemic stroke (AIS) and passed clinical trials as therapeutic drugs for AIS. The present study was a clinical trial to assess and compare the efficacy and safety of NBP and Cerebrolysin in the reduction of neurological and behavioral disability following AIS. A randomized, double-blind trial was conducted with enrolment of 60 patients within 12 h of AIS. In addition to routine treatment, patients were randomly assigned to receive a 10-day intravenous administration of NBP, Cerebrolysin or placebo...
May 2016: Experimental and Therapeutic Medicine
Carlos Solis-Gaspar, Ruben A Vazquez-Roque, Ma De Jesús Gómez-Villalobos, Gonzalo Flores
The spontaneously hypertensive (SH) rat has been used as an animal model of vascular dementia (VD). Our previous report showed that, SH rats exhibited dendritic atrophy of pyramidal neurons of the CA1 dorsal hippocampus and layers 3 and 5 of the prefrontal cortex (PFC) at 8 months of age. In addition, we showed that cerebrolysin (Cbl), a neurotrophic peptide mixture, reduces the dendritic atrophy in aged animal models. This study aimed to determine whether Cbl was capable of reducing behavioral and neuronal alterations, in old female SH rats...
September 2016: Synapse
O A Gromova, A G Kalacheva, T R Grishina, T E Bogacheva, V I Demidov, I Yu Torshin
AIM: To study an effect of cerebrolysin on the expression and severity of primary-generalized seizures caused by thiosemicarbazide and to analyze the corresponding molecular mechanisms. MATERIAL AND METHODS: The effects of cerebrolysin were studied on the thiosemicarbazide model of convulsions in 144 male rats. Cerebrolysin was introduced intraperitoneally in the dose of 2.5 ml/kg of body mass 5 days a week during 18 days. RESULTS AND CONCLUSION: Cerebrolysin reduces the severity and duration of seizures caused by thiosemicarbazide and increases the survival rate of animals...
2016: Zhurnal Nevrologii i Psikhiatrii Imeni S.S. Korsakova
Han-Yu Dong, Xin-Mei Jiang, Chun-Bo Niu, Lin Du, Jun-Yan Feng, Fei-Yong Jia
To examine the effects of Cerebrolysin on the treatment of diabetic peripheral neuropathy, we first established a mouse model of type 2 diabetes mellitus by administering a high-glucose, high-fat diet and a single intraperitoneal injection of streptozotocin. Mice defined as diabetic in this model were then treated with 1.80, 5.39 or 8.98 mL/kg of Cerebrolysin via intraperitoneal injections for 10 consecutive days. Our results demonstrated that the number, diameter and area of myelinated nerve fibers increased in the sciatic nerves of these mice after administration of Cerebrolysin...
January 2016: Neural Regeneration Research
A I Konoplya, V B Laskov, A A Shul'ginova
OBJECTIVE: To determine the dynamics of immunometabolic characteristics in patients with chronic ischemia of the brain (discirculatory encephalopathy - DE) under the influence of various combinations of neuroprotective and antioxidant drugs and on this basis to identify the most effective therapeutic combinations. MATERIAL AND METHODS: Authors analyzed the results of treatment of 57 patients with DE, stage II, comorbid to hypertension, stage II, which were divided into 3 groups that received comprehensive basic and advanced therapy with paired combinations of neuroprotective and antioxidant drugs...
2015: Zhurnal Nevrologii i Psikhiatrii Imeni S.S. Korsakova
L V Anosova, E A Levina, L S Chutko
OBJECTIVE: To study clinical/psychological characteristics in children with sensorineural hearing loss, IV degrees, before and after the cochlear implantation (CI) and to assess the dynamics of speech development during the rehabilitation using the neuroprotective drug cerebrolysin. MATERIAL AND METHODS: Authors examined 93 patients, aged from 5 to 8 years. The main group (n=46) received cerebrolysin, the control group was not treated with this drug. A diagnostic study included patient's history, neurological and neuropsychological examinations, auditory perception and sound reproduction...
2015: Zhurnal Nevrologii i Psikhiatrii Imeni S.S. Korsakova
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