A A Moosavi-Movahedi, S J Mousavy, A Divsalar, A Babaahmadi, K Karimian, A Shafiee, M Kamarie, N Poursasan, B Farzami, G H Riazi, G H Hakimelahi, F Y Tsai, F Ahmad, M Amani, A A Saboury
Transfusional iron overload is a major cause of morbidity and mortality in thalassemia, sickle-cell disease and other chronic anemias. To overcome these problems, orally bio available iron chelators, deferiprone and deferasirox, were used for the treatment of patients suffering from thalassemia. The interactions between deferiprone and deferasirox with the carrier protein, beta-thalassemia hemoglobin (Hb), were investigated using fluorescence, circular dichroism (CD) and UV-visible measurements at physiological condition...
December 2009: Journal of Biomolecular Structure & Dynamics