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hypertensive disorder of pregnancy

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https://www.readbyqxmd.com/read/28214384/placental-pathology-in-hiv-infection-at-term-a-comparison-with-hiv-uninfected-women
#1
Emma Kalk, Pawel Schubert, Julie A Bettinger, Mark F Cotton, Monika Esser, Amy Slogrove, Colleen A Wright
OBJECTIVES: To describe and correlate placental characteristics from pregnancies in HIV-infected and HIV-negative women with maternal and infant clinical and immunological data. METHODS: Prospective descriptive study of placentas from term, uncomplicated vaginal births in a cohort of HIV-infected (n=120) and HIV-negative (n=103) women in Cape Town, South Africa. Microscopic and macroscopic features were used to determine pathological cluster diagnoses. The majority of HIV-infected women received some form of drug treatment for the prevention of vertical transmission of HIV...
February 18, 2017: Tropical Medicine & International Health: TM & IH
https://www.readbyqxmd.com/read/28209494/effect-of-early-onset-preeclampsia-on-cardiovascular-risk-in-the-fifth-decade-of-life
#2
Anouk Bokslag, Pim W Teunissen, Constantijn Franssen, Floortje van Kesteren, Otto Kamp, Wessel Ganzevoort, Walter J Paulus, Christianne J M de Groot
BACKGROUND: Women with hypertensive disorders in pregnancy, in particular early-onset preeclampsia, are at increased risk of developing cardiovascular disease later in life. These women have a more than two-fold increased risk to die from cardiovascular diseases. Most studies focused on identification of risk factors shortly after pregnancy. Less is known on the prevalence of risk factors or actual signs of cardiovascular disease 5 - 20 years later. The presence of hypertension or metabolic syndrome can be seen as an opportunity for preventive interventions to reduce the development of severe cardiovascular diseases like myocardial infarction and stroke...
February 13, 2017: American Journal of Obstetrics and Gynecology
https://www.readbyqxmd.com/read/28208844/spectrum-of-factors-triggering-endothelial-dysfunction-in-pih
#3
Visala Sree Jammalamadaga, Philips Abraham
INTRODUCTION: Pre-eclampsia (PE) is a major cause of maternal and fetal/neonatal mortality and morbidity. The aetiology and pathogenesis of PE is yet to be completely understood. Evidence shows that, Endothelial Dysfunction (ED) plays a pivotal role in the genesis of this multi-system disorder that develops in PE and eclampsia. AIM: To determine the circulating levels of factors Malondialdehyde (MDA), Ferric Reducing Ability of Plasma-α (FRAP), Tumour Necrosis Factor (TNF-α), sFlt-1, VEGF, PlGF, Nitric Oxide (NO) that influence the ED...
December 2016: Journal of Clinical and Diagnostic Research: JCDR
https://www.readbyqxmd.com/read/28179623/provisional-criteria-for-the-diagnosis-of-hypertension-in-pregnancy-using-home-blood-pressure-measurements
#4
Yukiko Mikami, Yasushi Takai, Sumiko Era, Yoshihisa Ono, Masahiro Saitoh, Kazunori Baba, Hiromichi Suzuki, Hiroyuki Seki
Most guidelines for the management of hypertension define it as a home blood pressure (HBP) value >135/85 mm Hg. However, there is no reference HBP value to diagnose hypertension in pregnant women. Therefore, in this study, we analyzed HBP measurements of pregnant women to determine whether it is appropriate to use the criteria for non-pregnant subjects for pregnant women. The participants of this study were 100 singleton pregnant women who visited our hospital between September 2013 and September 2016...
February 9, 2017: Hypertension Research: Official Journal of the Japanese Society of Hypertension
https://www.readbyqxmd.com/read/28178739/methamphetamine-consumption-during-pregnancy-effects-on-child-health
#5
Jürgen Dinger, Patricia Hinner, Jörg Reichert, Mario Rüdiger
Methamphetamine abuse during pregnancy represents an emerging health care problem. The consequences are not only of relevance to the pregnant women, but also their unborn child. It is associated with an increased risk of preeclampsia and hypertension, fetal demise, preterm delivery, and intrauterine growth restriction. The deleterious effects of prenatal methamphetamine exposure on the developing fetal brain may lead to long-term neuro-developmental and behavioral problems.Given the current evidence, abuse of methamphetamine during pregnancy must be of utmost concern to health care professionals and to policy-makers...
February 8, 2017: Pharmacopsychiatry
https://www.readbyqxmd.com/read/28178057/recurrent-placenta-mediated-complications-in-women-with-three-consecutive-deliveries
#6
Liran Hiersch, Shiri Shinar, Nir Melamed, Amir Aviram, Eran Hadar, Yariv Yogev, Eran Ashwal
OBJECTIVE: To estimate the risk of placenta-mediated complications in women in their third delivery according to their obstetric history in the first and second deliveries. METHODS: A retrospective cohort study of all women with singleton pregnancies who delivered their first three consecutive deliveries in a single medical center over a 20-year period (1994-2013). The risk of placenta-mediated complications in the third delivery, that is, hypertensive disorders such as preeclampsia or gestational hypertension, placental abruption, and small for gestational age (SGA less than the 10th percentile), was assessed according to the presence or absence of complications in previous deliveries...
February 6, 2017: Obstetrics and Gynecology
https://www.readbyqxmd.com/read/28167685/external-validation-of-the-fullpiers-model-for-predicting-adverse-maternal-outcomes-in-pregnancy-hypertension-in-low-and-middle-income-countries
#7
U Vivian Ukah, Beth Payne, Tang Lee, Laura A Magee, Peter von Dadelszen
The hypertensive disorders of pregnancy are leading causes of maternal mortality and morbidity, especially in low- and middle-income countries. Early identification of women with preeclampsia and other hypertensive disorders of pregnancy at high risk of complications will aid in reducing this health burden. The fullPIERS model (Preeclampsia Integrated Estimate of Risk) was developed for predicting adverse maternal outcomes from preeclampsia using data from tertiary centers in high-income countries and uses maternal demographics, signs, symptoms, and laboratory tests as predictors...
February 6, 2017: Hypertension
https://www.readbyqxmd.com/read/28162026/the-effect-of-hypertensive-disorders-of-pregnancy-on-the-risk-of-adhd-in-the-offspring
#8
Stefanie Böhm, Eileen A Curran, Louise C Kenny, Gerard W O'Keeffe, Deirdre Murray, Ali S Khashan
OBJECTIVE: Evidence suggests that perinatal factors may contribute to the development of ADHD. Our objective was to examine the association between hypertensive disorders of pregnancy (HDP) and ADHD, and behavioral difficulties among 7-year-old children. METHOD: The study cohort consisted of 13,192 children (weighted = 13,500) who participated in the Millennium Cohort Study (MCS) at age 7. HDP (raised blood pressure, preeclampsia, eclampsia, and toxemia) were reported by mothers 9 months postdelivery...
January 1, 2017: Journal of Attention Disorders
https://www.readbyqxmd.com/read/28161306/a-randomized-clinical-trial-of-exercise-during-pregnancy-to-prevent-gestational-diabetes-mellitus-and-improve-pregnancy-outcome-in-overweight-and-obese-pregnant-women
#9
Chen Wang, Yumei Wei, Xiaoming Zhang, Yue Zhang, Qianqian Xu, Yiying Sun, Shiping Su, Li Zhang, Chunhong Liu, Yaru Feng, Chong Shou, Kym J Guelfi, John P Newnham, Huixia Yang
BACKGROUND: Obesity and being overweight are becoming epidemic, and indeed, the proportion of such women of reproductive age has increased in recent times. Being overweight or obese prior to pregnancy is a risk factor for gestational diabetes mellitus (GDM), and increases the risk of adverse pregnancy outcome for both mothers and their offspring. Furthermore, the combination of GDM with obesity/overweight status may increase the risk of adverse pregnancy outcome attributable to either factor alone...
February 1, 2017: American Journal of Obstetrics and Gynecology
https://www.readbyqxmd.com/read/28161265/-reasons-for-first-consultation-in-nephrology-in-the-health-area-5-of-britanny-during-the-year-2014
#10
Jeanne Prévot, Sahar Bayat-Makoei, Cécile Vigneau
BACKGROUND: In France, the coordinated healthcare circuit means that patients should be referred to specialists, for example nephrologists, by another physician. However, there are no recommendations concerning the reasons justifying the referral to a nephrologist. The main purpose of our study is to describe the motif of first consultations in nephrology in the health area 5 of Brittany. METHODS: We retrospectively collected medical reports of first consultations by 17 nephrologists in the 4 centers of the study area, during the year 2014...
February 1, 2017: Néphrologie & Thérapeutique
https://www.readbyqxmd.com/read/28153993/preterm-delivery-and-maternal-cardiovascular-disease-in-young-and-middle-aged-adult-women
#11
Lauren J Tanz, Jennifer J Stuart, Paige L Williams, Eric B Rimm, Stacey A Missmer, Kathryn M Rexrode, Kenneth J Mukamal, Janet W Rich-Edwards
BACKGROUND: Preterm delivery has been shown to be associated with increased risk of cardiovascular disease (CVD), but it is unknown whether this risk remains after adjustment for prepregnancy lifestyle and CVD risk factors. METHODS: We examined the association between history of having delivered an infant preterm (<37 weeks) and CVD in 70 182 parous women in the Nurses' Health Study II. Multivariable Cox proportional-hazards models were used to estimate hazards ratios (HRs) and 95% confidence intervals (CIs) for CVD events (myocardial infarction and stroke, n=949); we also adjusted for intermediates to determine the proportion of the association between preterm and CVD accounted for by postpartum development of CVD risk factors...
February 7, 2017: Circulation
https://www.readbyqxmd.com/read/28153855/hypertensive-disorder-of-pregnancy
#12
Robert Charles, Christopher Swales, Tess Bonnett, Phil Bonnett
No abstract text is available yet for this article.
February 2, 2017: BMJ: British Medical Journal
https://www.readbyqxmd.com/read/28153657/fertility-treatments-and-pediatric-neoplasms-of-the-offspring-results-of-a-population-based-cohort-with-a%C3%A2-median-follow-up-of-10-years
#13
Tamar Wainstock, Asnat Walfisch, Ilana Shoham-Vardi, Idit Segal, Avi Harlev, Ruslan Sergienko, Daniella Landau, Eyal Sheiner
OBJECTIVE: Studies have questioned the long-term health effects of offspring conceived after fertility treatments. METHODS: We aimed to evaluate whether an association exists between mode of conception (in vitro fertilization, ovulation induction, or spontaneous pregnancy) and neoplasm risk (both benign and malignant tumors) among the offspring; we observed the offspring for up to 18 years. STUDY DESIGN: A population-based cohort analysis was performed that compared the risk for neoplasms among children (up to the age of 18 years) based on mode of conception...
January 30, 2017: American Journal of Obstetrics and Gynecology
https://www.readbyqxmd.com/read/28153655/early-standardized-treatment-of-critical-blood-pressure-elevations-is-associated-with-a-reduction-in-eclampsia-and-severe-maternal-morbidity
#14
Laurence E Shields, Suzanne Wiesner, Catherine Klein, Barbara Pelletreau, Herman L Hedriana
BACKGROUND: Hypertensive disorders of pregnancy result in significant maternal morbidity and mortality. State and national guidelines have been proposed to increase treatment of patients with hypertensive emergencies or critically elevated blood pressures. There is limited data available to assess the impact of these recommendations on maternal morbidity. OBJECTIVE: The purpose of this prospective quality improvement project was to determine if maternal morbidity would be improved using a standardized approach for treatment of critically elevated blood pressures...
January 28, 2017: American Journal of Obstetrics and Gynecology
https://www.readbyqxmd.com/read/28151819/epidemiology-of-cardiac-arrest-during-hospitalization-for-delivery-in-canada-a-nationwide-study
#15
Mrinalini Balki, Shiliang Liu, Juan Andrés León, Leyla Baghirzada
BACKGROUND: Cardiac arrest in pregnancy is a rare and devastating condition with high mortality and morbidity. The objective of this study was to generate information about maternal cardiac arrest in Canada by examining the frequency, temporal incidence, associated conditions, potential etiologies, and survival rates. METHODS: This retrospective population-based study used hospitalization data from the discharge abstract database of the Canadian Institute for Health Information relating to obstetric deliveries in Canada from April 1, 2002, to March 31, 2015...
March 2017: Anesthesia and Analgesia
https://www.readbyqxmd.com/read/28151467/augmented-trophoblast-cell-death-in-preeclampsia-can-proceed-via-ceramide-mediated-necroptosis
#16
Liane Jennifer Bailey, Sruthi Alahari, Andrea Tagliaferro, Martin Post, Isabella Caniggia
Preeclampsia, a serious hypertensive disorder of pregnancy, is characterized by elevated ceramide (CER) content that is responsible for heightened trophoblast cell death rates via apoptosis and autophagy. Whether trophoblast cells undergo necroptosis, a newly characterized form of regulated necrosis, and the potential role of CER in this process remain to be established. Herein, we report that exposure of both JEG3 cells and primary isolated cytotrophoblasts to C16:0 CER in conjunction with a caspase-8 inhibitor (Q-VD-OPh) promoted necroptotic cell death, as evidenced by increased expression and association of receptor-interacting protein kinases RIP1 and RIP3, as well as phosphorylation of mixed lineage kinase domain-like (MLKL) protein...
February 2, 2017: Cell Death & Disease
https://www.readbyqxmd.com/read/28150433/impaired-maternal-hemodynamics-in-morbidly-obese-women-a-case-control-study
#17
D Vinayagam, J Gutierrez, J Binder, E Mantovani, B Thilaganathan, A Khalil
AIM: Maternal obesity is associated with significant pregnancy complications and is a risk factor for the development of hypertensive disorders of pregnancy as well as other adverse outcomes. There are few data regarding the hemodynamic aberrations observed in maternal obesity. The aim of this study was to investigate maternal hemodynamics in morbidly obese pregnant women. METHODS: This was a prospective, case-control study of morbidly obese women (BMI >40 kg/m(2) ) and controls (BMI 20-29...
February 2, 2017: Ultrasound in Obstetrics & Gynecology
https://www.readbyqxmd.com/read/28131123/update-in-the-management-of-patients-with-preeclampsia
#18
REVIEW
Nerlyne K Dhariwal, Grant C Lynde
Hypertensive disorders of pregnancy complicate approximately 10% of all deliveries in the United States and are a leading cause of maternal and fetal morbidity and mortality. Preeclampsia is defined as hypertension in association with proteinuria, thrombocytopenia, impaired liver function, renal insufficiency, pulmonary edema, or new-onset cerebral or visual disturbances. The greatest risk factor for the development of preeclampsia is a history of preeclampsia. There currently is no effective means for the prevention of preeclampsia...
March 2017: Anesthesiology Clinics
https://www.readbyqxmd.com/read/28125624/clonidine-versus-captopril-for-severe-postpartum-hypertension-a-randomized-controlled-trial
#19
Carlos Noronha Neto C, Sabina S B Maia, Leila Katz, Isabela C Coutinho, Alex R Souza, Melania M Amorim
BACKGROUND: Changes during the puerperium are still unclear, particularly in women with hypertension. The choice of antihypertensives, both to control very high blood pressure episodes and to keep blood pressure stable, also requires further elucidation. Currently, there are no clear data to guide the decision for the choice of postpartum antihypertensives. Captopril plays an important role in the treatment of very high blood pressure episodes and may be used postpartum. Clonidine has been used as an alternative in pregnant or postpartum women with contraindications to captopril, with satisfactory effect...
2017: PloS One
https://www.readbyqxmd.com/read/28122721/adverse-metabolic-phenotype-of-female-offspring-exposed-to-preeclampsia-in-utero-a-characterization-of-the-bph-5-mouse-in-postnatal-life
#20
Elizabeth F Sutton, Heinrich E Lob, Jiunn Song, Yunwei Xia, Scott D Butler, Chin-Chi Liu, Leanne M Redman, Jenny L Sones
Preeclampsia (PE) is a devastating disorder of pregnancy that classically presents with maternal hypertension and proteinuria after 20 weeks of gestation. In addition to being a leading cause of maternal and fetal morbidity/mortality, epidemiological and prospective studies have revealed long term consequences for both the mother and baby of preeclamptic pregnancies, including chronic hypertension as well as other cardiovascular diseases and metabolic derangements. To better understand the effect of in utero exposure of PE on offspring, we utilized the BPH/5 mouse, a spontaneous model of the maternal and fetal PE syndrome...
January 25, 2017: American Journal of Physiology. Regulatory, Integrative and Comparative Physiology
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