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https://www.readbyqxmd.com/read/27933507/determinants-of-maternal-vitamin%C3%A2-d-concentrations-in-slovenia-a%C3%A2-prospective-observational-study
#1
Andraž Dovnik, Faris Mujezinović, Milena Treiber, Breda Pečovnik Balon, Maksimiljan Gorenjak, Uroš Maver, Iztok Takač
OBJECTIVE: To analyze the vitamin D status of pregnant women in Slovenia and the factors influencing it. METHODS: The study was performed in Maribor University Medical Centre (location 46°N). Maternal serum 25-hydroxy-vitamin D (25(OH)D) in 4 groups of 100 pregnant women in 4 different seasons of the year was measured at the time of delivery. Data on life style, eating habits, sunbathing and intake of vitamin D supplements during pregnancy were obtained using a questionnaire...
December 8, 2016: Wiener Klinische Wochenschrift
https://www.readbyqxmd.com/read/27932770/-contrast-sensitivity-analysis-about-fundus-changes-of-hypertensive-disorders-complicating-pregnancy
#2
Zhixue Wang, Wenying Wang, Fengmei Han
To observe corrected visual acuity and contrast sensitivity (CS) in patients with hypertensive disorders complicating pregnancy accompanied by fundus changes.
 Methods: Ninety-eight patients with hypertensive disorders complicating pregnancy and 50 healthy pregnant women underwent eye examination, including corrected visual acuity and fundus examination, and CS. Differences in corrected visual acuity and contrast sensitivity between the 2 groups were analyzed with two independent samples t-test analysis, while correlation between vision and contrast sensitivity in patients was evaluated by using spearman correlation test...
November 28, 2016: Zhong Nan da Xue Xue Bao. Yi Xue Ban, Journal of Central South University. Medical Sciences
https://www.readbyqxmd.com/read/27931584/evaluation-of-pregnancy-outcomes-after-liver-transplantation
#3
M Akarsu, T Unek, A Avcu, M Ozbilgin, T Egeli, I Astarcioglu
Liver transplantation is increasing worldwide. Pregnancy after liver transplantation is considered to be well tolerated with favorable neonatal outcomes in cases of stable and sufficient graft function. In this study, our aim was to determine pregnancy and neonatal outcomes of patients after liver transplantation. Data for patients who had been followed-up by the liver transplantation clinic at the Dokuz Eylül University Medical Faculty Hospital, Turkey, between 2002 and 2016, and who had pregnancy after the transplantation were evaluated retrospectively...
December 2016: Transplantation Proceedings
https://www.readbyqxmd.com/read/27931277/american-academy-of-allergy-asthma-immunology-membership-experience-with-allergen-immunotherapy-safety-in-patients-with-specific-medical-conditions
#4
Dsire E S Larenas-Linnemann, David W Hauswirth, Christopher W Calabria, Lawrence D Sher, Matthew A Rank
BACKGROUND: Little data in the literature exist concerning patients with certain underlying medical conditions who receive allergen subcutaneous immunotherapy (SCIT). OBJECTIVE: To survey allergists' experience with SCIT in patients with medical conditions considered to impose an elevated risk for untoward outcomes. METHODS: A Web-based survey was conducted among members of the American Academy of Allergy, Asthma Immunology to query about their experience with SCIT in patients with certain medical conditions...
September 2016: Allergy and Asthma Proceedings:
https://www.readbyqxmd.com/read/27931267/western-diet-in-the-perinatal-period-promotes-dysautonomia-in-the-offspring-of-adult-rats
#5
R Vidal-Santos, F N Macedo, M N S Santana, V U De Melo, J L de Brito Alves, M R V Santos, L C Brito, E Nascimento, J H Costa-Silva, V J Santana-Filho
The present study investigated the impact of a western diet during gestation and lactation on the anthropometry, serum biochemical, blood pressure and cardiovascular autonomic control on the offspring. Male Wistar rats were divided into two groups according to their mother's diet received: control group (C: 18% calories of lipids) and westernized group (W: 32% calories of lipids). After weaning both groups received standard diet. On the 60th day of life, blood samples were collected for the analysis of fasting glucose and lipidogram...
December 9, 2016: Journal of Developmental Origins of Health and Disease
https://www.readbyqxmd.com/read/27928067/lower-limb-venous-diameters-and-haemodynamics-during-pregnancy-and-postpartum-period-in-healthy-primigravidae
#6
Leandro Augusto Gardenghi, Nei Rodrigues Alves Dezotti, Marcelo Bellini Dalio, Wellington de Paula Martins, Edwaldo Edner Joviliano, Carlos Eli Piccinato
OBJECTIVE: Analyse venous haemodynamics in healthy primigravidae during pregnancy and in the postpartum. METHODS: Cohort with primigravidae evaluated in the three trimesters of pregnancy and postpartum. Duplex evaluated venous diameters and reflux; air plethysmography evaluated venous filling index, ejection fraction, residual volume fraction and outflow fraction in both limbs. RESULTS: During pregnancy, diameters increased in bilateral common femoral and right infravalvar great saphenous, but returned to first trimester values after delivery...
December 6, 2016: Phlebology
https://www.readbyqxmd.com/read/27927652/nicotinamide-ameliorates-a-preeclampsia-like-condition-in-mice-with-reduced-uterine-perfusion-pressure
#7
Tomofumi Fushima, Akiyo Sekimoto, Yuji Oe, Emiko Sato, Sadayoshi Ito, Hiroshi Sato, Nobuyuki Takahashi
Background - Preeclampsia (PE) is pregnancy-induced hypertension with proteinuria that typically develops after 20 weeks of gestation. Anti-hypertensives currently used for PE reduce blood pressure of PE mothers, but do not prevent pre-term delivery, and do not alleviate fetal growth restriction (FGR) associated with PE. We have recently shown that the activation of the ET system exacerbates PE. However, ET receptor antagonists are teratogenic and not suitable for pregnant women. A vitamin B3 nicotinamide (Nam) inhibits vasoconstriction by ET, is generally considered safe and harmless to babies...
December 7, 2016: American Journal of Physiology. Renal Physiology
https://www.readbyqxmd.com/read/27927625/sympathetic-responsiveness-is-not-increased-in-women-with-a-history-of-hypertensive-pregnancy
#8
Sushant M Ranadive, Ronee E Harvey, Brian D Lahr, Virginia M Miller, Michael J Joyner, Jill N Barnes
Hypertensive pregnancy (HTNP) is a risk factor for future cardiovascular disease. Exaggerated cardiovascular responses to physical stress are also considered an independent marker of cardiovascular disease risk. However, there are limited data regarding the blood pressure (BP) responses to acute stress in women, who have a history of HTNP. Hence, the aim of the study is to compare BP responses to a physical stress in postmenopausal women with a history of HTNP to age- and parity-matched women with a history of normotensive pregnancy (NP)...
December 7, 2016: American Journal of Physiology. Regulatory, Integrative and Comparative Physiology
https://www.readbyqxmd.com/read/27926975/large-for-gestational-age-infants-and-adverse-outcomes-among-uncomplicated-pregnancies-at-term
#9
Hector Mendez-Figueroa, Van Thi Thanh Truong, Claudia Pedroza, Suneet P Chauhan
Background While traumatic delivery with large for gestational age (LGA; birth weight above 90%) is acknowledged, there is paucity of data regarding other morbidity and mortality associated with LGA. Our hypothesis was that compared with appropriate for gestational age (AGA), LGA have a significantly higher rate of composite neonatal morbidity (CNM). Objective Our objective was to compare the CNM among uncomplicated LGA versus AGA at term (37 weeks or more) among all available Maternal-Fetal Medicine Units (MFMU) databases...
December 7, 2016: American Journal of Perinatology
https://www.readbyqxmd.com/read/27926659/macroprolactinomas-and-nonfunctioning-pituitary-adenomas-and-pregnancy-outcomes
#10
Kimberley Lambert, Kate Rees, Paul T Seed, Mandish K Dhanjal, Marian Knight, David R McCance, Catherine Williamson
OBJECTIVE: To examine the monitoring, management, and outcomes of pituitary tumors in pregnancy. METHODS: A national, prospective, observational, population-based case series study was conducted in all U.K. consultant-led obstetric units over 3 years using the U.K. Obstetric Surveillance System. To evaluate rates of adverse pregnancy outcomes, women with a macroprolactinoma (10 mm or greater) or nonfunctioning pituitary adenoma, diagnosed before or during pregnancy, were compared with two comparison groups: 1) a U...
December 2, 2016: Obstetrics and Gynecology
https://www.readbyqxmd.com/read/27926645/association-between-sleep-disordered-breathing-and-hypertensive-disorders-of-pregnancy-and-gestational-diabetes-mellitus
#11
Francesca L Facco, Corette B Parker, Uma M Reddy, Robert M Silver, Matthew A Koch, Judette M Louis, Robert C Basner, Judith H Chung, Chia-Ling Nhan-Chang, Grace W Pien, Susan Redline, William A Grobman, Deborah A Wing, Hyagriv N Simhan, David M Haas, Brian M Mercer, Samuel Parry, Daniel Mobley, Shannon Hunter, George R Saade, Frank P Schubert, Phyllis C Zee
OBJECTIVE: To estimate whether sleep-disordered breathing during pregnancy is a risk factor for the development of hypertensive disorders of pregnancy and gestational diabetes mellitus (GDM). METHODS: In this prospective cohort study, nulliparous women underwent in-home sleep-disordered breathing assessments in early (6-15 weeks of gestation) and midpregnancy (22-31 weeks of gestation). Participants and health care providers were blinded to the sleep test results...
December 2, 2016: Obstetrics and Gynecology
https://www.readbyqxmd.com/read/27926640/preeclampsia-and-long-term-risk-of-maternal-retinal-disorders
#12
Nathalie Auger, William D Fraser, Gilles Paradis, Jessica Healy-Profitós, Ada Hsieh, Marc-André Rhéaume
OBJECTIVE: To evaluate whether preeclampsia is associated with risk of maternal retinal disease in the decades after pregnancy. METHODS: We carried out a longitudinal cohort study of 1,108,541 women who delivered neonates in any hospital in Quebec, Canada, between 1989 and 2013. We tracked women for later hospitalizations until March 31, 2014. Preeclampsia was measured at delivery categorized by severity (mild or severe) and onset (before or at 34 weeks or more of gestation)...
December 2, 2016: Obstetrics and Gynecology
https://www.readbyqxmd.com/read/27926639/angiotensin-converting-enzyme-inhibitors-and-the-risk-of-congenital-malformations
#13
Brian T Bateman, Elisabetta Patorno, Rishi J Desai, Ellen W Seely, Helen Mogun, Sara Z Dejene, Michael A Fischer, Alexander M Friedman, Sonia Hernandez-Diaz, Krista F Huybrechts
OBJECTIVE: To examine the association between first-trimester angiotensin-converting enzyme (ACE) inhibitor exposure and the risk of overall major congenital, cardiac, and central nervous system malformations. METHODS: We used a cohort of completed pregnancies linked to liveborn neonates derived from Medicaid claims from 2000 to 2010. We examined the risk of malformations associated with first-trimester exposure to an ACE inhibitor. Propensity score-based methods were used to control for potential confounders including maternal demographics, medical conditions, exposure to other medications, and measures of health care utilization...
December 2, 2016: Obstetrics and Gynecology
https://www.readbyqxmd.com/read/27924661/sleep-disordered-breathing-in-pregnancy-the-maternal-and-fetal-implications
#14
Shanthi Carnelio, Adam Morton, H David McIntyre
Sleep disordered breathing (SDB) which includes obstructive sleep apnoea (OSA) and upper airway resistance syndrome (UARS), has emerged as a risk factor for adverse maternal-foetal outcomes in pregnancy. Physiological changes of pregnancy predispose a woman 'at risk' towards developing SDB. The increasing incidence of OSA in pregnancy closely correlates with the population trends of obesity. Common screening tools validated in non-pregnant subjects including Epworth Sleepiness Scale (ESS) and Berlin Questionnaire (BQ) are poor predictors of SDB in pregnancy...
December 7, 2016: Journal of Obstetrics and Gynaecology: the Journal of the Institute of Obstetrics and Gynaecology
https://www.readbyqxmd.com/read/27920343/epidermal-growth-factor-rescues-endothelial-dysfunction-in-primary-human-tissues-in-vitro
#15
Roxanne Hastie, Stephen Tong, Natalie J Hannan, Fiona Brownfoot, Ping Cannon, Tu'uhevaha J Kaitu'u-Lino
Preeclampsia is a hypertensive disorder of pregnancy, responsible for over 60 000 maternal deaths annually. Endothelial dysfunction is a central aspect to its pathophysiology, and currently, no medical therapeutic is available for its treatment. In this study, we aim to investigate the effect of epidermal growth factor (EGF) on endothelial dysfunction using primary human tissues. We performed a number of in vitro assays that mimic the vascular endothelial dysfunction that occurs in preeclampsia. Epidermal growth factor reduced the expression of vascular cell adhesion molecule-1, a marker of endothelial dysfunction, after insult with tumor necrosis factor α (TNF-α) or serum from women with preeclampsia...
December 5, 2016: Reproductive Sciences
https://www.readbyqxmd.com/read/27919602/hematocrit-and-plasma-albumin-levels-difference-may-be-a-potential-biomarker-to-discriminate-preeclampsia-and-eclampsia-in-patients-with-hypertensive-disorders-of-pregnancy
#16
Dong-Mei Dai, Jing Cao, Hong-Mei Yang, Hai-Mei Sun, Yu Su, Yuan-Yuan Chen, Xiao Fang, Wang-Bin Xu
BACKGROUND: We evaluated whether alterations of hemoglobin (HB), hematocrit (HCT), serum albumin level (ALB), and the difference of HCT and ALB can be used in the diagnosis of preeclampsia and eclampsia in patients with hypertensive disorders of pregnancy (HDP). METHODS: A total of 509 individuals were recruited and divided into 4 groups: Group 1, 170 healthy non-pregnant women; Group 2, 125 normal pregnant women; Group 3, 105 pregnant women diagnosed with gestational and chronic hypertension; Group 4, 109 pregnant women diagnosed as having preeclampsia and eclampsia...
December 2, 2016: Clinica Chimica Acta; International Journal of Clinical Chemistry
https://www.readbyqxmd.com/read/27918585/the-association-of-family-history-of-premature-cardiovascular-disease-or-diabetes-mellitus-on-the-occurrence-of-gestational-hypertensive-disease-and-diabetes
#17
Dong-Ju Choi, Chang-Hwan Yoon, Heesun Lee, So-Yeon Ahn, Kyung Joon Oh, Hyun-Young Park, Hea Young Lee, Myeong Chan Cho, Ick-Mo Chung, Mi-Seung Shin, Sung-Ji Park, Chi Young Shim, Seong Woo Han, In-Ho Chae
BACKGROUND: Gestational hypertensive diseases (GHD) and gestational diabetes mellitus (GDM) increase the risk of cardiovascular disease (CVD) later in life. However, the association between gestational medical diseases and familial history of CVD has not been investigated to date. In the present study, we examined the association between familial history of CVD and GHD or GDM via reliable questionnaires in a large cohort of registered nurses. METHODS: The Korean Nurses' Survey was conducted through a web-based computer-assisted self-interview, which was developed through consultation with cardiologists, gynecologists, and statisticians...
2016: PloS One
https://www.readbyqxmd.com/read/27914214/antithrombin-improves-the-maternal-and-neonatal-outcomes-but-not-the-angiogenic-factors-in-extremely-growth-restricted-fetuses-at-28-weeks-of-gestation
#18
Midori Fujisaki, Ken Furuta, Masanao Ohhashi, Seishi Furukawa, Yuki Kodama, Yasuyuki Kawagoe, Hiroshi Sameshima, Tsuyomu Ikenoue
AIMS: Severe preterm fetal growth restriction (FGR) remote from term is problematic. We aimed to investigate the effect of maternally-administered antithrombin on maternal and neonatal outcomes. A prospective, one-arm, pilot study was performed in 14 women with severe FGR (≤5th centile) at <28 weeks of gestation, without hypertensive disorders. Maternal plasma concentrations of soluble Feline McDonough Sarcoma (FMS)-like trypsin kinase-1 (sFlt-1) and placental growth factor (PlGF) were measured and categorized into three groups: group 1; low sFlt-1 and high PlGF, group 2; moderate sFlt-1 and low PlGF, and group 3; high sFlt-1 and low PlGF...
December 3, 2016: Journal of Perinatal Medicine
https://www.readbyqxmd.com/read/27913562/relationship-between-maternal-hypoglycaemia-and-small-for-gestational-age-infants-according-to-maternal-weight-status-a-retrospective-cohort-study-in-two-hospitals
#19
Satoshi Shinohara, Yuzo Uchida, Mitsuo Hirai, Shuji Hirata, Kohta Suzuki
OBJECTIVE: The relationship between pre-pregnancy body mass index (BMI) and low glucose challenge test (GCT) results by maternal weight status has not been examined. This study aimed to clarify the relationship between a low GCT result and small for gestational age (SGA) by maternal weight status. DESIGN: A retrospective cohort study in 2 hospitals. SETTING: This study evaluated the obstetric records of women who delivered in a general community hospital and a tertiary perinatal care centre...
December 2, 2016: BMJ Open
https://www.readbyqxmd.com/read/27911105/associations-between-maternal-bmi-as-well-as-glucose-tolerance-and-adverse-pregnancy-outcomes-in-women-with-polycystic-ovary-syndrome
#20
Ying-Ying Li, Su-Qi Ye, Zhuo-Hui Zhong, Qiong Xu, Wei-Bi Mai, Cai-Xin Yin, Zhi-Qin Zhu, Xiao-Qian He, Qing Xiao
This retrospective, cohort study examined the association between maternal pre-pregnancy body mass index (BMI), independent of glucose tolerance and adverse pregnancy outcomes in women with polycystic ovary syndrome (PCOS), for which there are few previous studies. Medical records from 2012 to 2015 at Guangzhou Women and Children's Medical Center, China were reviewed for women previously diagnosed with PCOS with normal 2-h 75-g oral glucose tolerance test (OGTT) results (n = 1249). The separate and joint effects of maternal BMI and glucose levels on pregnancy outcomes were assessed...
December 2, 2016: Gynecological Endocrinology
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