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computational model mental illness

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https://www.readbyqxmd.com/read/28894744/advances-in-mobile-mental-health-opportunities-and-implications-for-the-spectrum-of-e-mental-health-services
#1
REVIEW
Donald M Hilty, Steven Chan, Tiffany Hwang, Alice Wong, Amy M Bauer
Mobile health (mHealth), telemedicine and other technology-based services facilitate mental health service delivery and may be considered part of an e-mental health (eMH) spectrum of care. Web- and Internet-based resources provide a great opportunity for the public, patients, healthcare providers and others to improve wellness, practice prevention and reduce suffering from illnesses. Mobile apps offer portability for access anytime/anywhere, are inexpensive versus traditional desktop computers, and have additional features (e...
2017: MHealth
https://www.readbyqxmd.com/read/28819746/the-effects-of-resistance-exercise-training-on-anxiety-a-meta-analysis-and-meta-regression-analysis-of-randomized-controlled-trials
#2
REVIEW
Brett R Gordon, Cillian P McDowell, Mark Lyons, Matthew P Herring
BACKGROUND: The salutary effects of resistance exercise training (RET) are well established, including increased strength and function; however, less is known regarding the effects of RET on mental health outcomes. Aerobic exercise has well-documented positive effects on anxiety, but a quantitative synthesis of RET effects on anxiety is needed. OBJECTIVES: To estimate the population effect size for resistance exercise training (RET) effects on anxiety and to determine whether variables of logical, theoretical, and/or prior empirical relation to anxiety moderate the overall effect...
August 17, 2017: Sports Medicine
https://www.readbyqxmd.com/read/28663166/researching-mental-health-disorders-in-the-era-of-social-media-systematic-review
#3
REVIEW
Akkapon Wongkoblap, Miguel A Vadillo, Vasa Curcin
BACKGROUND: Mental illness is quickly becoming one of the most prevalent public health problems worldwide. Social network platforms, where users can express their emotions, feelings, and thoughts, are a valuable source of data for researching mental health, and techniques based on machine learning are increasingly used for this purpose. OBJECTIVE: The objective of this review was to explore the scope and limits of cutting-edge techniques that researchers are using for predictive analytics in mental health and to review associated issues, such as ethical concerns, in this area of research...
June 29, 2017: Journal of Medical Internet Research
https://www.readbyqxmd.com/read/28626813/hallucinations-as-top-down-effects-on-perception
#4
Albert R Powers, Megan Kelley, Philip R Corlett
The problem of whether and how information is integrated across hierarchical brain networks embodies a fundamental tension in contemporary cognitive neuroscience, and by extension, cognitive neuropsychiatry. Indeed, the penetrability of perceptual processes in a 'top-down' manner by higher-level cognition-a natural extension of hierarchical models of perception-may contradict a strictly modular view of mental organization. Furthermore, some in the cognitive science community have challenged cognitive penetration as an unlikely, if not impossible, process...
September 2016: Biological Psychiatry: Cognitive Neuroscience and Neuroimaging
https://www.readbyqxmd.com/read/28398574/can-rdoc-help-find-order-in-thought-disorder
#5
REVIEW
Alex S Cohen, Thanh P Le, Taylor L Fedechko, Brita Elvevåg
Thought disorder is a pernicious and nonspecific aspect of numerous serious mental illnesses (SMIs) and related conditions. Despite decades of empirical research on thought disorder, our present understanding of it is poor, our clinical assessments focus on a limited set of extreme behaviors, and treatments are palliative at best. Applying a Research Domain Criteria (RDoC) framework to thought disorder research offers advantages to explicate its phenotype; isolate its mechanisms; and develop more effective assessments, treatments, and potential cures...
May 1, 2017: Schizophrenia Bulletin
https://www.readbyqxmd.com/read/28283561/alteration-of-neuronal-excitability-and-short-term-synaptic-plasticity-in-the-prefrontal-cortex-of-a-mouse-model-of-mental-illness
#6
Gregg W Crabtree, Ziyi Sun, Mirna Kvajo, Jantine A C Broek, Karine Fénelon, Heather McKellar, Lan Xiao, Bin Xu, Sabine Bahn, James M O'Donnell, Joseph A Gogos
Using a genetic mouse model that faithfully recapitulates a DISC1 genetic alteration strongly associated with schizophrenia and other psychiatric disorders, we examined the impact of this mutation within the prefrontal cortex. Although cortical layering, cytoarchitecture, and proteome were found to be largely unaffected, electrophysiological examination of the mPFC revealed both neuronal hyperexcitability and alterations in short-term synaptic plasticity consistent with enhanced neurotransmitter release. Increased excitability of layer II/III pyramidal neurons was accompanied by consistent reductions in voltage-activated potassium currents near the action potential threshold as well as by enhanced recruitment of inputs arising from superficial layers to layer V...
April 12, 2017: Journal of Neuroscience: the Official Journal of the Society for Neuroscience
https://www.readbyqxmd.com/read/28202786/dopamine-modulates-adaptive-prediction-error-coding-in-the-human-midbrain-and-striatum
#7
RANDOMIZED CONTROLLED TRIAL
Kelly M J Diederen, Hisham Ziauddeen, Martin D Vestergaard, Tom Spencer, Wolfram Schultz, Paul C Fletcher
Learning to optimally predict rewards requires agents to account for fluctuations in reward value. Recent work suggests that individuals can efficiently learn about variable rewards through adaptation of the learning rate, and coding of prediction errors relative to reward variability. Such adaptive coding has been linked to midbrain dopamine neurons in nonhuman primates, and evidence in support for a similar role of the dopaminergic system in humans is emerging from fMRI data. Here, we sought to investigate the effect of dopaminergic perturbations on adaptive prediction error coding in humans, using a between-subject, placebo-controlled pharmacological fMRI study with a dopaminergic agonist (bromocriptine) and antagonist (sulpiride)...
February 15, 2017: Journal of Neuroscience: the Official Journal of the Society for Neuroscience
https://www.readbyqxmd.com/read/27824803/caregiving-immediately-after-stroke-a-study-of-uncertainty-in-caregivers-of-older-adults
#8
Eeeseung Byun, Barbara Riegel, Marilyn Sommers, Nancy Tkacs, Lois Evans
BACKGROUND: Caregivers of stroke survivors experience high rates of mental and physical morbidity. Stroke has sudden onset, and the outcome is not immediately known. Uncertainties surrounding the new caregiving role may not only necessitate major changes in the lives of family caregivers but also contribute to negative health outcomes for the caregiver. PURPOSE: The purposes of this study were to describe caregiver uncertainty across the early weeks after a family member's stroke and to explore characteristics of caregivers and stroke survivors associated with that uncertainty...
December 2016: Journal of Neuroscience Nursing: Journal of the American Association of Neuroscience Nurses
https://www.readbyqxmd.com/read/27793131/what-s-all-the-talk-about-topic-modelling-in-a-mental-health-internet-support-group
#9
Bradley Carron-Arthur, Julia Reynolds, Kylie Bennett, Anthony Bennett, Kathleen M Griffiths
BACKGROUND: The majority of content in an Internet Support Group (ISG) is contributed by 1 % of the users ('super users'). Computational methods, such as topic modelling, can provide a large-scale quantitative objective description of this content. Such methods may provide a new perspective on the nature of engagement on ISGs including the role of super users and their possible effect on other users. METHODS: A topic model was computed for all posts (N = 131,004) in the ISG BlueBoard using Latent Dirichlet Allocation...
October 28, 2016: BMC Psychiatry
https://www.readbyqxmd.com/read/27782973/giving-voice-to-all-patients-on-patients-at-the-margins-and-their-intention-and-perceived-ability-to-complain
#10
Torsten Oliver Salge, David Antons, Patrick Cichy, J Nils Foege, Julian Hannen, Antje S J Huetten
BACKGROUND: It is now widely established that health care organizations are well advised not only to identify and act upon the concerns of all patient groups but also to encourage and enable them to voice their concerns in the first place. That said, research has begun to reveal that patients differ substantially in their readiness to complain, with many deciding to remain silent even after experiencing severe adverse events. Little research has explored whether patients at the margins (e...
October 25, 2016: Health Care Management Review
https://www.readbyqxmd.com/read/27703840/continuum-beliefs-in-the-stigma-process-regarding-persons-with-schizophrenia-and-depression-results-of-path-analyses
#11
Anna C Makowski, Eva E Mnich, Matthias C Angermeyer, Olaf von dem Knesebeck
BACKGROUND: Individuals with mental illness often experience stigmatization and encounter stereotypes such as being dangerous or unpredictable. To further improve measures against psychiatric stigma, it is of importance to understand its components. In this study, we attend to the step of separation between "us" and "them" in the stigma process as conceptualized by Link and Phelan. In using the belief in continuity of mental illness symptoms as a proxy for separation, we explore its associations with stereotypes, emotional responses and desire for social distance in the stigma process...
2016: PeerJ
https://www.readbyqxmd.com/read/27604363/randomised-controlled-trial-of-a-digitally-assisted-low-intensity-intervention-to-promote-personal-recovery-in-persisting-psychosis-smart-therapy-study-protocol
#12
RANDOMIZED CONTROLLED TRIAL
Neil Thomas, John Farhall, Fiona Foley, Susan L Rossell, David Castle, Emma Ladd, Denny Meyer, Cathrine Mihalopoulos, Nuwan Leitan, Cassy Nunan, Rosalie Frankish, Tara Smark, Sue Farnan, Bronte McLeod, Leon Sterling, Greg Murray, Ellie Fossey, Lisa Brophy, Michael Kyrios
BACKGROUND: Psychosocial interventions have an important role in promoting recovery in people with persisting psychotic disorders such as schizophrenia. Readily available, digital technology provides a means of developing therapeutic resources for use together by practitioners and mental health service users. As part of the Self-Management and Recovery Technology (SMART) research program, we have developed an online resource providing materials on illness self-management and personal recovery based on the Connectedness-Hope-Identity-Meaning-Empowerment (CHIME) framework...
September 7, 2016: BMC Psychiatry
https://www.readbyqxmd.com/read/27573365/maternal-exposure-to-the-water-soluble-fraction-of-crude-oil-lead-and-their-mixture-induces-autism-like-behavioral-deficits-in-zebrafish-danio-rerio-larvae
#13
Yuanchuan Wang, Hongxiu Zhong, Chonggang Wang, Dongxu Gao, Yulin Zhou, Zhenghong Zuo
Autism spectrum disorder (ASD) is a serious debilitating mental illness with complex symptoms and multi-factorial pathogenesis. Although the pathogenesis of ASD remains unclear, etiology is thought to involve complex, multigenic interactions and possible environmental contributions. In the present study, we used zebrafish (Danio rerio) as a model to investigate whether maternal exposure to the water soluble fraction of crude oil (WSF, 5μg/L), lead (Pb, 20μg/L) and their mixture (5 μg/L WSF+20 μg/L Pb) could induce autism-like behavior in larvae...
August 26, 2016: Ecotoxicology and Environmental Safety
https://www.readbyqxmd.com/read/27038085/virtual-patient-simulation-in-psychiatric-care-a-pilot-study-of-digital-support-for-collaborate-learning
#14
Charlotta Sunnqvist, Karin Karlsson, Lisbeth Lindell, Uno Fors
Psychiatric and mental health nursing is built on a trusted nurse and patient relationship. Therefore communication and clinical reasoning are two important issues. Our experiences as teachers in psychiatric educational programmes are that the students feel anxiety and fear before they start their clinical practices in psychiatry. Therefore there is a need for bridging over the fear. Technology enhanced learning might support such activities so we used Virtual patients (VPs), an interactive computer simulations of real-life clinical scenarios...
March 2016: Nurse Education in Practice
https://www.readbyqxmd.com/read/26968151/an-examination-of-the-language-construct-in-nimh-s-research-domain-criteria-time-for-reconceptualization
#15
REVIEW
Brita Elvevåg, Alex S Cohen, Maria K Wolters, Heather C Whalley, Viktoria-Eleni Gountouna, Ksenia A Kuznetsova, Andrew R Watson, Kristin K Nicodemus
The National Institute of Mental Health's Research Domain Criteria (RDoC) Initiative "calls for the development of new ways of classifying psychopathology based on dimensions of observable behavior." As a result of this ambitious initiative, language has been identified as an independent construct in the RDoC matrix. In this article, we frame language within an evolutionary and neuropsychological context and discuss some of the limitations to the current measurements of language. Findings from genomics and the neuroimaging of performance during language tasks are discussed in relation to serious mental illness and within the context of caveats regarding measuring language...
September 2016: American Journal of Medical Genetics. Part B, Neuropsychiatric Genetics
https://www.readbyqxmd.com/read/26906507/computational-psychiatry-as-a-bridge-from-neuroscience-to-clinical-applications
#16
REVIEW
Quentin J M Huys, Tiago V Maia, Michael J Frank
Translating advances in neuroscience into benefits for patients with mental illness presents enormous challenges because it involves both the most complex organ, the brain, and its interaction with a similarly complex environment. Dealing with such complexities demands powerful techniques. Computational psychiatry combines multiple levels and types of computation with multiple types of data in an effort to improve understanding, prediction and treatment of mental illness. Computational psychiatry, broadly defined, encompasses two complementary approaches: data driven and theory driven...
March 2016: Nature Neuroscience
https://www.readbyqxmd.com/read/26554711/identifying-causal-risk-factors-for-violence-among-discharged-patients
#17
Jeremy W Coid, Constantinos Kallis, Mike Doyle, Jenny Shaw, Simone Ullrich
BACKGROUND: Structured Professional Judgement (SPJ) is routinely administered in mental health and criminal justice settings but cannot identify violence risk above moderate accuracy. There is no current evidence that violence can be prevented using SPJ. This may be explained by routine application of predictive instead of causal statistical models when standardising SPJ instruments. METHODS: We carried out a prospective cohort study of 409 male and female patients discharged from medium secure services in England and Wales to the community...
2015: PloS One
https://www.readbyqxmd.com/read/26489912/characteristics-of-trafficked-adults-and-children-with-severe-mental-illness-a-historical-cohort-study
#18
Siân Oram, Mizanur Khondoker, Melanie Abas, Matthew Broadbent, Louise M Howard
BACKGROUND: Evidence regarding the mental health needs of trafficked people is limited; however, prevalence of depression and post-traumatic stress disorder is high among trafficked people who are in contact with shelter services. We aimed to investigate the sociodemographic and clinical characteristics of trafficked people with severe mental illness. METHODS: We did a historical cohort study of trafficked people in contact with secondary mental health services in South London, UK, between Jan 1, 2006, and July 31, 2012...
December 2015: Lancet Psychiatry
https://www.readbyqxmd.com/read/26383904/dopamine-depressive-symptoms-and-decision-making-the-relationship-between-spontaneous-eye-blink-rate-and-depressive-symptoms-predicts-iowa-gambling-task-performance
#19
Kaileigh A Byrne, Dominique D Norris, Darrell A Worthy
Depressive symptomatology has been associated with alterations in decision-making, although conclusions have been mixed, with depressed individuals showing impairments in some contexts but advantages in others. The dopaminergic system may link depressive symptoms with decision-making performance. We assessed the role of striatal dopamine D2 receptor density, using spontaneous eye blink rates, in moderating the relationship between depressive symptoms and decision-making performance in a large undergraduate sample that had not been screened for mental illness (N = 104)...
February 2016: Cognitive, Affective & Behavioral Neuroscience
https://www.readbyqxmd.com/read/26371267/a-participatory-model-of-the-paradox-of-primary-care
#20
Laura Homa, Johnie Rose, Peter S Hovmand, Sarah T Cherng, Rick L Riolo, Alison Kraus, Anindita Biswas, Kelly Burgess, Heide Aungst, Kurt C Stange, Kalanthe Brown, Margaret Brooks-Terry, Ellen Dec, Brigid Jackson, Jules Gilliam, George E Kikano, Ann Reichsman, Debbie Schaadt, Jamie Hilfer, Christine Ticknor, Carl V Tyler, Anna Van der Meulen, Heather Ways, Richard F Weinberger, Christine Williams
PURPOSE: The paradox of primary care is the observation that primary care is associated with apparently low levels of evidence-based care for individual diseases, but systems based on primary care have healthier populations, use fewer resources, and have less health inequality. The purpose of this article is to explore, from a complex systems perspective, mechanisms that might account for the effects of primary care beyond disease-specific care. METHODS: In an 8-session, participatory group model-building process, patient, caregiver, and primary care clinician community stakeholders worked with academic investigators to develop and refine an agent-based computer simulation model to test hypotheses about mechanisms by which features of primary care could affect health and health equity...
September 2015: Annals of Family Medicine
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