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https://www.readbyqxmd.com/read/29806089/fish-analysis-of-selected-soft-tissue-tumors-diagnostic-experience-in-a-tertiary-center
#1
Ana Cristina Vargas, Christina Selinger, Laveniya Satgunaseelan, Wendy A Cooper, Ruta Gupta, Paul Stalley, Wendy Brown, Judy Soper, Julie Schatz, Richard Boyle, David M Thomas, Martin H N Tattersall, Vivek Bhadri, Fiona Maclean, Sally Fiona Bonar, Richard A Scolyer, Rooshdiya Z Karim, Stanley W McCarthy, Annabelle Mahar, Sandra A O'Toole
AIM: Fluorescence in situ hybridization (FISH) is an important ancillary tool for the classification of bone/soft tissue (BST) tumors. The aim of this study was to evaluate the contribution of FISH to the final classification of common BST entities in the molecular pathology department of the Royal Prince Alfred Hospital (RPAH), which is one of the most important referral centers for the management of sarcomas in Australia. METHODS: All routine diagnostic FISH tests performed on BST formalin-fixed paraffin embedded (FFPE) tissue specimens at the RPAH in a 5-year period (February, 2010-November, 2015) were reviewed...
May 28, 2018: Asia-Pacific Journal of Clinical Oncology
https://www.readbyqxmd.com/read/29693546/self-management-of-gestational-diabetes-among-chinese-migrants-a-qualitative-study
#2
Yat Yin Eric Wah, Margaret McGill, Jencia Wong, Glynis P Ross, Anna-Jane Harding, Ines Krass
BACKGROUND: Gestational diabetes mellitus is one of the most common complications of pregnancy. Women with Gestational diabetes are at increased risk of serious health outcomes, such as pre-eclampsia, obstructed labor, and the development of Type 2 diabetes later in life. Chinese migrants, the third largest cultural group in Australia, are more likely to develop Gestational diabetes than Australian-born women. However, to date, Gestational diabetes self-management has not been investigated in this population...
April 21, 2018: Women and Birth: Journal of the Australian College of Midwives
https://www.readbyqxmd.com/read/29674362/implementation-of-an-evidence-based-model-of-care-for-low-back-pain-in-emergency-departments-protocol-for-the-sydney-health-partners-emergency-department-shaped-trial
#3
Gustavo C Machado, Bethan Richards, Chris Needs, Rachelle Buchbinder, Ian A Harris, Kirsten Howard, Kirsten McCaffery, Laurent Billot, James Edwards, Eileen Rogan, Rochelle Facer, David Lord Cowell, Chris G Maher
INTRODUCTION: Patients with low back pain often seek care in emergency departments, but the problem is that many patients receive unnecessary or ineffective interventions and at the same time miss out on the basics of care, such as advice on self-management. This pattern of care has important consequences for the healthcare system (expensive and inefficient) and for patients (poor health outcomes). We hypothesised that the implementation of an evidence-based model of care for low back pain will improve emergency care by reducing inappropriate overuse of tests and treatments and improving patient outcomes...
April 19, 2018: BMJ Open
https://www.readbyqxmd.com/read/29569991/examining-perceived-stress-childhood-trauma-and-interpersonal-trauma-in-individuals-with-drug-addiction
#4
Julia Garami, Ahmad Valikhani, Denise Parkes, Paul Haber, Justin Mahlberg, Blazej Misiak, Dorota Frydecka, Ahmed A Moustafa
The investigation of psychosocial factors in relation to opiate addiction is limited and typically uses binary measures to assess how incidences of childhood trauma correlate with addiction. There has also been a lack of enquiry into how experiences of noninterpersonal versus interpersonal trauma may impact drug use addiction. In this regard, the current study utilized a novel measurement of interpersonal versus noninterpersonal lifetime trauma and a scale assessing severity of childhood trauma to examine how these factors may impact patients with opioid addiction...
January 1, 2018: Psychological Reports
https://www.readbyqxmd.com/read/29452599/feasibility-and-acceptability-of-pre-operative-physical-activity-to-improve-patient-outcomes-after-major-cancer-surgery-study-protocol-for-a-pilot-randomised-controlled-trial-pepa-trial
#5
Daniel Steffens, Jane Young, Paula R Beckenkamp, James Ratcliffe, Freya Rubie, Nabila Ansari, Neil Pillinger, Michael Solomon
BACKGROUND: There is a need for evidence of the effectiveness of pre-operative exercise for patients undergoing major cancer surgery; however, recruitment to such trials can be challenging. The PrE-operative Physical Activity (PEPA) Trial will establish the feasibility and acceptability of a pre-operative exercise programme aimed to improve patient outcomes after cytoreductive surgery and pelvic exenteration. The secondary aim is to obtain pilot data on the likely difference in key outcomes (post-operative complications, length of hospital stay, post-operative functional capacity and quality of life) to inform the sample size calculation for the substantive randomised clinical trial...
February 17, 2018: Trials
https://www.readbyqxmd.com/read/29438637/population-attributable-fractions-of-perinatal-outcomes-for-nulliparous-women-associated-with-overweight-and-obesity-1990-2014
#6
Kate Cheney, Rachel Farber, Alexandra L Barratt, Kevin McGeechan, Bradley de Vries, Robert Ogle, Kirsten I Black
OBJECTIVE: To examine the prevalence across 25 years of overweight and obesity among nulliparous Australian women during early pregnancy; to estimate the proportions of adverse perinatal outcomes attributable to overweight and obesity in this population. DESIGN: Cohort study; retrospective analysis of electronic maternity data. Setting, participants: 42 582 nulliparous women with singleton pregnancies giving birth at the Royal Prince Alfred Hospital, an urban teaching hospital in Sydney, January 1990 - December 2014...
February 19, 2018: Medical Journal of Australia
https://www.readbyqxmd.com/read/29355895/is-ultrasound-measured-fetal-biometry-predictive-of-intrapartum-caesarean-section-for-failure-to-progress
#7
Jenny M Yang, Jon A Hyett, Kevin Mcgeechan, Hala Phipps, Bradley S de Vries
BACKGROUND: There are global concerns regarding excessive caesarean rates, which could be reduced by identification of risk factors leading to preventative measures such as induction of labour. AIMS: This study aims to describe the association between antenatal ultrasound and emergency caesarean section for: (i) failure to progress; (ii) other indications; and (iii) any indication. MATERIALS AND METHODS: Women who had an ultrasound in pregnancy between 36(+0/7) to 38(+6/7) weeks at Royal Prince Alfred Hospital from January 2005 to June 2009 were included...
January 22, 2018: Australian & New Zealand Journal of Obstetrics & Gynaecology
https://www.readbyqxmd.com/read/29132146/identification-of-unique-neoantigen-qualities-in-long-term-survivors-of-pancreatic-cancer
#8
Vinod P Balachandran, Marta Łuksza, Julia N Zhao, Vladimir Makarov, John Alec Moral, Romain Remark, Brian Herbst, Gokce Askan, Umesh Bhanot, Yasin Senbabaoglu, Daniel K Wells, Charles Ian Ormsby Cary, Olivera Grbovic-Huezo, Marc Attiyeh, Benjamin Medina, Jennifer Zhang, Jennifer Loo, Joseph Saglimbeni, Mohsen Abu-Akeel, Roberta Zappasodi, Nadeem Riaz, Martin Smoragiewicz, Z Larkin Kelley, Olca Basturk, Mithat Gönen, Arnold J Levine, Peter J Allen, Douglas T Fearon, Miriam Merad, Sacha Gnjatic, Christine A Iacobuzio-Donahue, Jedd D Wolchok, Ronald P DeMatteo, Timothy A Chan, Benjamin D Greenbaum, Taha Merghoub, Steven D Leach
Pancreatic ductal adenocarcinoma is a lethal cancer with fewer than 7% of patients surviving past 5 years. T-cell immunity has been linked to the exceptional outcome of the few long-term survivors, yet the relevant antigens remain unknown. Here we use genetic, immunohistochemical and transcriptional immunoprofiling, computational biophysics, and functional assays to identify T-cell antigens in long-term survivors of pancreatic cancer. Using whole-exome sequencing and in silico neoantigen prediction, we found that tumours with both the highest neoantigen number and the most abundant CD8+ T-cell infiltrates, but neither alone, stratified patients with the longest survival...
November 23, 2017: Nature
https://www.readbyqxmd.com/read/28960252/does-previous-caesarean-section-at-full-dilatation-increase-the-likelihood-of-subsequent-spontaneous-preterm-birth
#9
Angela Cong, Bradley de Vries, Joanne Ludlow
BACKGROUND: There is emerging evidence that caesarean section at full dilatation is associated with an increased risk of subsequent spontaneous preterm birth. AIM: To investigate the association between caesarean section at full dilatation and spontaneous preterm birth in subsequent pregnancies. MATERIALS AND METHODS: This was a retrospective cohort study of women who had two consecutive births at Royal Prince Alfred Hospital, 1989-2015. Our main comparison group was women who had emergency caesarean sections during the first stage of labour...
September 28, 2017: Australian & New Zealand Journal of Obstetrics & Gynaecology
https://www.readbyqxmd.com/read/28526329/a-behaviour-change-intervention-to-reduce-sedentary-time-in-people-with-chronic-obstructive-pulmonary-disease-protocol-for-a-randomised-controlled-trial
#10
Sonia Wing Mei Cheng, Jennifer Alison, Sarah Dennis, Emmanuel Stamatakis, Lissa Spencer, Renae McNamara, Susan Sims, Zoe McKeough
INTRODUCTION: Replacing sedentary behaviour with light intensity physical activity (ie, activities classified as less than three metabolic equivalents, such as slow-paced walking) may be a more realistic strategy for reducing cardiometabolic risk in people with chronic obstructive pulmonary disease than only aiming to increase levels of moderate-vigorous intensity physical activity. Behaviour change interventions to reduce sedentary behaviour in people with chronic obstructive pulmonary disease have not yet been developed or tested...
July 2017: Journal of Physiotherapy
https://www.readbyqxmd.com/read/28251638/the-impact-of-introducing-medical-management-on-conservative-and-surgical-management-for-early-pregnancy-miscarriage
#11
Kirsten I Black, Bradley S de Vries, Francis Moses, Marilena Pelosi, Angela Cong, Joanne Ludlow
BACKGROUND: Medical management of miscarriage allows women to avoid the risks associated with surgical intervention. In 2011 the early pregnancy assessment service (EPAS) at the Royal Prince Alfred Hospital (RPAH) in Sydney, Australia introduced medical management of miscarriage with single-dose 800 μg vaginal misoprostol. AIMS: We sought to investigate the impact of the introduction of medical management had on the proportion of women having surgery and conservative management and to examine the success and complication rates of medical management...
February 2017: Australian & New Zealand Journal of Obstetrics & Gynaecology
https://www.readbyqxmd.com/read/28226344/-diagnostic-criteria-and-risk-assessment-of-complications-after-gastric-cancer-surgery-in-western-countries
#12
Zhouqiao Wu, Qi Wang, Jinyao Shi, Koh Cherry, Jacopo Desiderio, Ziyu Li, Jiafu Ji
Postoperative complications are important outcome measurements for surgical quality and safety control. However, the complication registration has always been problematic due to the lack of definition consensus and the other practical difficulties. This narrative review summarizes the data registry system for single institutional registry, national data registry, international multi-center trial registries in the western world, aiming to share the experience of complication classification and data registration...
February 25, 2017: Zhonghua Wei Chang Wai Ke za Zhi, Chinese Journal of Gastrointestinal Surgery
https://www.readbyqxmd.com/read/28153986/improving-cardiovascular-health-in-diverse-populations-a-conversation-with-anushka-patel-mbbs-sm-phd
#13
Anushka Patel, John D Rutherford
Anushka Patel is the Chief Scientist, The George Institute for Global Health, Professor of Medicine, University of Sydney and a Cardiologist, at Royal Prince Alfred Hospital, all based in Sydney, Australia. She obtained her MBBS from the University of Queensland, a Master of Science degree in Epidemiology from Harvard University, and her PhD from the University of Sydney.
February 7, 2017: Circulation
https://www.readbyqxmd.com/read/27797673/baseline-hba1c-to-identify-high-risk-gestational-diabetes-utility-in-early-vs-standard-gestational-diabetes
#14
COMPARATIVE STUDY
Arianne N Sweeting, Glynis P Ross, Jon Hyett, Lynda Molyneaux, Kris Tan, Maria Constantino, Anna Jane Harding, Jencia Wong
Context: The increasing prevalence of gestational diabetes mellitus (GDM) necessitates risk stratification directing limited antenatal resources to those at greatest risk. Recent evidence demonstrates that an early pregnancy glycated hemoglobin (HbA1c ≥5.9% (41 mmol/mol) predicts adverse pregnancy outcomes. Objective: To determine the optimal HbA1c threshold for adverse pregnancy outcomes in GDM in a treated multiethnic cohort and whether this differs in women diagnosed <24 vs ≥24 weeks' gestation (early vs standard GDM)...
January 1, 2017: Journal of Clinical Endocrinology and Metabolism
https://www.readbyqxmd.com/read/27639677/egfr-co-mutated-advanced-nsclc-and-response-to-egfr-tyrosine-kinase-inhibitors
#15
Megan B Barnet, Sandra O'Toole, Lisa G Horvath, Christina Selinger, Bing Yu, Chiu Chin Ng, Michael Boyer, Wendy A Cooper, Steven Kao
OBJECTIVES: The evolution of EGFR tyrosine kinase inhibitors (TKIs) has changed the landscape of disease for a subset of patients with NSCLC. Most patients with an EGFR mutation respond to these drugs; however, a proportion show limited or no tumor response. We explored the impact of co-mutation (double or multiple mutation), compared with a single mutation, of the EGFR gene on response to TKIs in a series of patients with metastatic NSCLC. METHODS: We retrospectively analyzed the mutation profiles of nonsquamous NSCLC tested at Royal Prince Alfred Hospital between 2012 and 2015 by MassArray using the OncoCarta v1...
March 2017: Journal of Thoracic Oncology
https://www.readbyqxmd.com/read/27575810/late-rupture-of-abdominal-aortic-aneurysm-after-endovascular-repair
#16
COMPARATIVE STUDY
Saissan Rajendran, James May
OBJECTIVE: The purpose of this study was to compare findings at presentation and surgical outcomes in patients in whom abdominal aortic aneurysms (AAAs) ruptured after endovascular repair and in patients in whom AAAs ruptured before any treatment during a defined period at a single center. METHODS: This is a retrospective analysis of consecutive patients who presented to Royal Prince Alfred Hospital with ruptured AAA from September 2003 to September 2014. Medical records of each patient were reviewed to retrieve demographics, findings at presentation, and surgical outcome...
January 2017: Journal of Vascular Surgery
https://www.readbyqxmd.com/read/27497145/cultural-issues-and-other-factors-that-affect-self-management-of-type-2-diabetes-mellitus-t2d-by-chinese-immigrants-in-australia
#17
Kexin Eh, Margaret McGill, Jencia Wong, Ines Krass
AIMS: To investigate the influence of cultural and other factors on diabetes self-management behaviors among Australian Chinese immigrants with T2D. METHODS: A cross-sectional survey was conducted between June and October 2015. The questionnaire comprised several validated scales examining aspects of self-management practice including medication adherence, acculturation and demographics. Participants were recruited from the community and Diabetes Center of the Royal Prince Alfred Hospital (RPAH), Sydney, Australia...
September 2016: Diabetes Research and Clinical Practice
https://www.readbyqxmd.com/read/27488338/elevated-serum-thyroglobulin-levels-at-the-time-of-ablative-radioactive-iodine-therapy-indicate-a-worse-prognosis-in-thyroid-cancer-an-australian-retrospective-cohort-study
#18
T J Matthews, E Chua, A Gargya, J Clark, K Gao, M Elliott
BACKGROUND: Serum thyroglobulin is used as a surrogate marker for well-differentiated thyroid carcinoma recurrence. This study investigates whether thyroglobulin measured at the time of ablative radioactive iodine therapy predicts disease-free survival. METHODS: A retrospective review was conducted of patients with well-differentiated thyroid carcinoma presenting from 1989 to 2010 at the Royal Prince Alfred Hospital, New South Wales, Australia. Disease-free survival of patients with a significantly elevated stimulated thyroglobulin level (27...
July 2016: Journal of Laryngology and Otology
https://www.readbyqxmd.com/read/27456285/the-introduction-of-expired-air-resuscitation-into-surf-life-saving-australia
#19
C M Ball
Surf Life Saving Australia, which began in the early 1900s, initially adopted the indirect resuscitation methods used by the Royal Life Saving Society. As new indirect methods became available, both organisations adapted their resuscitation techniques and followed international developments closely. In the 1950s, accumulating evidence suggested that direct methods of resuscitation, such as mouth-to-mouth ventilation, might be more efficacious. Subsequently a number of investigations were carried out in Sydney at the Royal Prince Alfred Hospital on anaesthetised and paralysed patients...
July 2016: Anaesthesia and Intensive Care
https://www.readbyqxmd.com/read/27306144/complications-of-external-cephalic-version-a-retrospective-analysis-of-1121-patients-at-a-tertiary-hospital-in-sydney
#20
R Rodgers, N Beik, N Nassar, I Brito, B de Vries
OBJECTIVE: To report the complication rate associated with external cephalic version (ECV) at term. DESIGN: Single-centre retrospective study. SETTING: A major tertiary hospital in Sydney, Australia. POPULATION OR SAMPLE: All women who underwent an ECV at Royal Prince Alfred Hospital from 1995-2013 were included. METHODS: ECV was attempted on all consenting women with a breech presentation at term in the absence of contraindications...
April 2017: BJOG: An International Journal of Obstetrics and Gynaecology
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