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Royal Prince Alfred

Megan B Barnet, Sandra O'Toole, Lisa G Horvath, Christina Selinger, Bing Yu, Chiu Chin Ng, Michael Boyer, Wendy A Cooper, Steven Kao
OBJECTIVES: The evolution of EGFR tyrosine kinase inhibitors (TKIs) has changed the landscape of disease for a subset of patients with NSCLC. Most patients with an EGFR mutation respond to these drugs; however, a proportion show limited or no tumor response. We explored the impact of co-mutation (double or multiple mutation), compared with a single mutation, of the EGFR gene on response to TKIs in a series of patients with metastatic NSCLC. METHODS: We retrospectively analyzed the mutation profiles of nonsquamous NSCLC tested at Royal Prince Alfred Hospital between 2012 and 2015 by MassArray using the OncoCarta v1...
September 14, 2016: Journal of Thoracic Oncology
Saissan Rajendran, James May
OBJECTIVE: The purpose of this study was to compare findings at presentation and surgical outcomes in patients in whom abdominal aortic aneurysms (AAAs) ruptured after endovascular repair and in patients in whom AAAs ruptured before any treatment during a defined period at a single center. METHODS: This is a retrospective analysis of consecutive patients who presented to Royal Prince Alfred Hospital with ruptured AAA from September 2003 to September 2014. Medical records of each patient were reviewed to retrieve demographics, findings at presentation, and surgical outcome...
August 26, 2016: Journal of Vascular Surgery
Kexin Eh, Margaret McGill, Jencia Wong, Ines Krass
AIMS: To investigate the influence of cultural and other factors on diabetes self-management behaviors among Australian Chinese immigrants with T2D. METHODS: A cross-sectional survey was conducted between June and October 2015. The questionnaire comprised several validated scales examining aspects of self-management practice including medication adherence, acculturation and demographics. Participants were recruited from the community and Diabetes Center of the Royal Prince Alfred Hospital (RPAH), Sydney, Australia...
September 2016: Diabetes Research and Clinical Practice
T J Matthews, E Chua, A Gargya, J Clark, K Gao, M Elliott
BACKGROUND: Serum thyroglobulin is used as a surrogate marker for well-differentiated thyroid carcinoma recurrence. This study investigates whether thyroglobulin measured at the time of ablative radioactive iodine therapy predicts disease-free survival. METHODS: A retrospective review was conducted of patients with well-differentiated thyroid carcinoma presenting from 1989 to 2010 at the Royal Prince Alfred Hospital, New South Wales, Australia. Disease-free survival of patients with a significantly elevated stimulated thyroglobulin level (27...
July 2016: Journal of Laryngology and Otology
C M Ball
Surf Life Saving Australia, which began in the early 1900s, initially adopted the indirect resuscitation methods used by the Royal Life Saving Society. As new indirect methods became available, both organisations adapted their resuscitation techniques and followed international developments closely. In the 1950s, accumulating evidence suggested that direct methods of resuscitation, such as mouth-to-mouth ventilation, might be more efficacious. Subsequently a number of investigations were carried out in Sydney at the Royal Prince Alfred Hospital on anaesthetised and paralysed patients...
July 2016: Anaesthesia and Intensive Care
R Rodgers, N Beik, N Nassar, I Brito, B de Vries
OBJECTIVE: To report the complication rate associated with external cephalic version (ECV) at term. DESIGN: Single-centre retrospective study. SETTING: A major tertiary hospital in Sydney, Australia. POPULATION OR SAMPLE: All women who underwent an ECV at Royal Prince Alfred Hospital from 1995-2013 were included. METHODS: ECV was attempted on all consenting women with a breech presentation at term in the absence of contraindications...
June 16, 2016: BJOG: An International Journal of Obstetrics and Gynaecology
Rowena McMullan, Adrienne Gordon
OBJECTIVE To compare central line use and central line-associated bloodstream infection in newborn infants before and after the introduction of a central line infection prevention bundle in order to determine the effectiveness of the bundle and to identify areas for further improvement. DESIGN Retrospective cohort analysis of prospectively collected data. SETTING Level 5 neonatal intensive care unit in Sydney, Australia. PATIENTS Newborn infants admitted to the Royal Prince Alfred Hospital Neonatal Intensive Care Unit who had a central venous catheter (CVC) inserted...
September 2016: Infection Control and Hospital Epidemiology
Edward A Cooper, Katie J De-Loyde, Christopher J Young, Heather L Shepherd, Caroline Wright
PURPOSE: Faecal incontinence (FI) is a debilitating condition, which affects approximately 2-17 % of the population. Clinical assessment, physiological testing and imaging are usually used to evaluate the pathophysiology and guide management of FI. By analysing patient characteristics, symptoms and investigative findings, the aim of this study was to identify which patient characteristics and investigations influence patient management. METHODS: Data was prospectively collected for all patients with FI presenting to a single surgeon at the Royal Prince Alfred Hospital, Sydney, between March 2002 and September 2013...
August 2016: International Journal of Colorectal Disease
Emily Nash, Charlotte Hespe, Dane Chalkley
OBJECTIVES: Our primary aim was to analyse the quality of letters from general practitioners (GPs) to the ED as defined by two checklists: the authors' own nine-item list and a template published in 2013 by the New South Wales Agency for Clinical Innovation. The secondary aim was to determine if referral quality was influenced by letter format (handwritten or computer-generated) or urgency of the patient's condition (defined by triage category). METHODS: The present study is a retrospective audit of records of patients presenting to Royal Prince Alfred Hospital ED from a GP during February and March 2014...
June 2016: Emergency Medicine Australasia: EMA
Richard T White, Martin McGee-Collett
OBJECTIVE: The objective of this study was to describe the advent of prefrontal lobotomy in Sydney and, less comprehensively, its introduction into Australia. METHOD: Reference to journal articles, books, reports and archival data held at the Royal Prince Alfred Hospital and via internet searches, interviews and personal memory. RESULT: This paper describes the arrival of psychosurgery in Sydney in the mid-1940s, and less comprehensively, its arrival in other Australian cities...
March 9, 2016: Australasian Psychiatry: Bulletin of Royal Australian and New Zealand College of Psychiatrists
Richard T White, Martin McGee-Collett
OBJECTIVE: The objective of this article is to provide a portrait of prefrontal lobotomy performed at the Royal Prince Alfred Hospital, Sydney by the Head of Neurosurgery Dr Rex Money and to describe Dr Money's role in the promotion of psychosurgery in Sydney. METHODS: We draw attention to an oral presentation by Dr Rex Money in 1951, a journal article written by Money, archival information held at the Royal Prince Alfred Hospital, including Dr Money's accounts of his travels and his reports regarding neurosurgery - both internationally and in Australia...
March 9, 2016: Australasian Psychiatry: Bulletin of Royal Australian and New Zealand College of Psychiatrists
Annette Burgess, Tim Dornan, Antonia J Clarke, Audrey Menezes, Craig Mellis
BACKGROUND: Peer tutoring has been described as "people from similar social groupings who are not professional teachers helping each other to learn and learning themselves by teaching". Peer tutoring is well accepted as a source of support in many medical curricula, where participation and learning involve a process of socialisation. Peer tutoring can ease the transition of the junior students from the university class environment to the hospital workplace. In this paper, we apply the Experienced Based Learning (ExBL) model to explore medical students' perceptions of their experience of taking part in a newly established peer tutoring program at a hospital based clinical school...
2016: BMC Medical Education
A J Quyn, K K S Austin, J M Young, T Badgery-Parker, L M Masya, R Roberts, M J Solomon
INTRODUCTION: Radical surgery with pelvic exenteration offers the only potential for cure in patients with locally advanced primary rectal cancer. This study describes the clinical and patient-reported quality of life outcomes over 12 months for patients having pelvic exenteration for locally advanced primary rectal cancer at a specialised centre for pelvic exenteration. METHODS: Clinical data of consecutive patients undergoing pelvic exenteration for locally advanced primary rectal cancer and patient-reported outcomes were collected at baseline, hospital discharge and at 1, 3, 6, 9 and 12 months...
June 2016: European Journal of Surgical Oncology
Anthony J Marren, Ying Ying Tan, Bradley S de Vries, Cecilia H M Ng, Mark Livingstone, Mark C Bowman
BACKGROUND: Currently, the viability of cryostored blastocysts that are subsequently re-warmed is determined via the percentage of cell survival. However, the large number of cells that forms the blastocyst can make this estimate difficult and unreliable. Studies have shown that fast re-expanding blastocysts have superior pregnancy rates. AIM: To determine whether the degree and speed of blastocoele re-expansion following cryopreservation and warming correlate with rates of live birth...
June 2016: Australian & New Zealand Journal of Obstetrics & Gynaecology
Cheryl Au, Neil Sharma, Peter McCluskey, Raf Ghabrial
BACKGROUND: Giant cell arteritis (GCA) is a systemic inflammatory vasculitis of large- and medium-sized arteries. Superficial temporal artery biopsy (STAB) of at least 20 mm has traditionally been the standard length for histopathology to accurately diagnose GCA. Recent studies suggest than a post-fixation STAB length of 7 to 10 mm is adequate for diagnosing GCA. This article is protected by copyright. All rights reserved. DESIGN: This is a retrospective observational study PARTICIPANTS OR SAMPLES: All patients who underwent STAB at Royal Prince Alfred Hospital, a large tertiary teaching hospital in Sydney, Australia, from 2008 to 2014...
February 29, 2016: Clinical & Experimental Ophthalmology
Gemma Blain, Anthony Richards, Selvan Pather, Jonathan Carter, Sam Saidi
BACKGROUND: The current Australian National Health and Medical Research Council guidelines discourage the use of 'see and treat' colposcopic management due to concerns regarding over-treatment. However, this approach has been shown to have benefits in several studies, including cost savings, elimination of loss to follow up and decreased patient anxiety. AIMS: To provide Australian data on treatment outcomes for women presenting with a high-grade Pap smear to a large metropolitan colposcopy unit and to determine whether a 'see and treat' approach would meet specified standards...
April 2016: Australian & New Zealand Journal of Obstetrics & Gynaecology
Cheryl Pui Yan Au, Camille H Raynes-Greenow, Robin M Turner, Angela E Carberry, Heather E Jeffery
OBJECTIVE: Pregnancies complicated with gestational diabetes mellitus (GDM) are at a higher risk for caesarean and instrumental deliveries as well as adverse neonatal outcomes such as fetal overgrowth, hypoglycaemia and neonatal intensive care admission. Our primary objective was to describe neonatal outcomes in a sample that included term infants of both GDM mothers and mothers with normal glucose tolerance (NGT). DESIGN AND SETTING: this cross-sectional study included 599 term babies born between September and October 2010 at Royal Prince Alfred Hospital, Sydney, Australia...
March 2016: Midwifery
Peter P Luk, Jared D Weston, Bing Yu, Christina I Selinger, Rafael Ekmejian, Timothy J Eviston, Trina Lum, Kan Gao, Michael Boyer, Sandra A O'Toole, Jonathan R Clark, Ruta Gupta
BACKGROUND: Accurate diagnosis of salivary duct carcinoma requires a high index of suspicion and clinicopathologic correlation. Hallmark genetic changes that may provide novel therapeutic options are being explored. METHODS: One hundred ninety salivary gland malignancies at Royal Prince Alfred Hospital (from 1989-2014) were reviewed. Human epidermal growth factor receptor 2 (HER2) and androgen receptor status were determined along with multigene profiling. RESULTS: Twenty-three salivary duct carcinomas were identified, predominantly in men in their fifth to ninth decades of life...
April 2016: Head & Neck
Christopher J Young, Katie J De-Loyde, Jane M Young, Michael J Solomon, Emily H Chew, Chris M Byrne, Glenn Salkeld, Ian G Faragher
BACKGROUND: Surgery remains the dominant treatment for large-bowel obstruction, with emerging data on self-expanding metallic stents. OBJECTIVE: The aim of this study was to assess whether stent insertion improves quality of life and survival in comparison with surgical decompression. DESIGN: This study reports on a randomized control trial (registry number ACTRN012606000199516). SETTING: This study was conducted at Royal Prince Alfred Hospital, Sydney, and Western Hospital, Melbourne...
September 2015: Diseases of the Colon and Rectum
Ritu Mogra, Rahmah Saaid, Greg Kesby, Janette Hayward, Jessica Malkoun, Jon Hyett
BACKGROUND: There is a growing body of evidence that most of the major cardiac abnormalities can be diagnosed at 14-15 weeks of gestation. We present our experience of early fetal echocardiography. MATERIALS AND METHODS: This is a retrospective cohort study of women referred for early fetal echocardiography at 13-16 weeks of gestation at Royal Prince Alfred Hospital and Sydney Ultrasound for Women between August 2011 and March 2014. Findings of early fetal echocardiography, details of subsequent ultrasound examinations and pregnancy outcome were recorded...
December 2015: Australian & New Zealand Journal of Obstetrics & Gynaecology
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