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https://www.readbyqxmd.com/read/29446693/hyperparathyroidism-mimicking-metastatic-bone-disease-a-case-report-and-review-of-literature
#1
Monica Gupta, Lalita Singhal, Akshay Kumar
Multiple osteolytic lesions are usually associated with metastatic involvement of the bone; however, metabolic bone diseases should also be included in the differential diagnosis. In this study, we describe a case of primary hyperparathyroidism (PHPT) with multiple osteolytic lesions that was diagnosed initially as having metastatic bone involvement. The laboratory results showed hypercalcemia and raised alkaline phosphatase along with fibrosis in the bone marrow biopsy with no increase in tumor markers and normal serum protein electrophoresis...
February 15, 2018: Journal of Adolescent and Young Adult Oncology
https://www.readbyqxmd.com/read/29446565/targeted-surgical-parathyroidectomy-in-end-stage-renal-disease-patients-and-long-term-metabolic-control-a-single-center-experience-in-the-current-era
#2
Tibor Fülöp, Christian A Koch, Abdeen R Farah Musa, Christopher M Clark, Kamel A Gharaibeh, Zsolt Lengvársky, Mehrdad Hamrahian, Karen T Pitman, Mehul P Dixit
BACKGROUND: The long-term results of surgical parathyroidectomy (PTX) in end-stage renal disease (ESRD) patients are less well known in the modern era of newer activated vitamin-D analogs, calcimimetics and intraoperative monitoring of parathyroid hormone (PTH). METHODS: We performed a retrospective chart review of all ESRD patients undergoing PTX at the University of Mississippi Medical Center between January 2005 and August 2011, with follow-up data as available up to 4 years...
February 15, 2018: Hemodialysis International
https://www.readbyqxmd.com/read/29445392/how-many-parathyroid-glands-can-be-identified-during-thyroidectomy-evidence-based-data-for-medical-experts
#3
Elisabeth Gschwandtner, Rudolf Seemann, Claudia Bures, Lejla Preldzic, Eduard Szucsik, Michael Hermann
Background: The purpose of this study is to provide guidance for medical experts regarding malpractice claims on permanent hypoparathyroidism by analyzing the number of parathyroid glands (PGs) identified during thyroidectomy and the clinical outcome. Methods: Parathyroid findings were documented in a standardized protocol for 357 patients undergoing thyroidectomy and treated by a single specialized surgeon. The resected thyroid was routinely dissected for accidentally removed PGs with consecutive autotransplantation and the pathological report also described unintentionally resected PGs...
2018: European Surgery: ACA: Acta Chirurgica Austriaca
https://www.readbyqxmd.com/read/29441335/clinical-usefulness-of-intraoperative-parathyroid-hormone-monitoring-for-primary-hyperparathyroidism
#4
Se Hyun Paek, Su-Jin Kim, June Young Choi, Kyu Eun Lee
Purpose: The availability of intraoperative parathyroid hormone (IOPTH) monitoring allows successful focused parathyroidectomy for primary hyperparathyroidism (pHPT). The objective of this study was to report our initial experience in IOPTH monitoring during parathyroid surgery for primary hyperparathyroidsim. Methods: Between May 2011 and February 2013, 37 patients underwent focused parathyroidectomy due to pHPT. IOPTH monitoring based on Miami criteria was used to confirm complete excision of hyperfunctioning parathyroid gland during surgery...
February 2018: Annals of Surgical Treatment and Research
https://www.readbyqxmd.com/read/29430234/excision-of-an-elusive-tiny-ectopic-parathyroid-adenoma
#5
Andre Navarro, Josanne Vassallo, Joseph Galea
An elderly lady was diagnosed with primary hyperparathyroidism after being admitted to hospital with pyelonephritis and constipation. A sestamibi parathyroid scan demonstrated increased uptake in the upper mediastinum, suggesting an ectopic mediastinal parathyroid adenoma. The 4-mm adenoma was successfully removed through a mini-sternotomy incision using a gamma probe to identify the gland from the surrounding tissue. The patient made an uneventful recovery.
September 2017: Case Reports in Oncology
https://www.readbyqxmd.com/read/29429003/parathyroid-autotransplantation-in-thyroid-surgery
#6
REVIEW
Antonio Sitges-Serra, Leyre Lorente-Poch, Juan Sancho
BACKGROUND: Careful parathyroid gland dissection and in situ preservation was the time-honored approach to prevent parathyroid failure after total thyroidectomy. The relative success of parathyroid autotransplantation of hyperplastic parathyroid tissue in patients with renal or hereditary hyperparathyroidism did popularize the use of normal parathyroid tissue autografts during thyroidectomy to prevent permanent hypoparathyroidism. Proof of autograft function in this setting, however, is controversial...
February 10, 2018: Langenbeck's Archives of Surgery
https://www.readbyqxmd.com/read/29411199/detection-of-parathyroid-autofluorescence-using-near-infrared-imaging-a-multicenter-analysis-of-concordance-between-different-surgeons
#7
Bora Kahramangil, Fernando Dip, Fares Benmiloud, Jorge Falco, Martin de La Fuente, Silvina Verna, Raul Rosenthal, Eren Berber
BACKGROUND: Parathyroid glands (PGs) exhibit autofluorescence (AF) when excited by near-infrared laser. This multicenter study aims to analyze how this imaging could facilitate the detection of PGs during thyroidectomy and parathyroidectomy procedures. METHODS: This was a retrospective Institutional Review Board-approved analysis of prospectively collected data at three centers. Near-infrared fluorescence imaging (NIFI) was used to detect AF from PGs during thyroidectomy and parathyroidectomy procedures...
February 6, 2018: Annals of Surgical Oncology
https://www.readbyqxmd.com/read/29409478/parathyroid-cysts-experience-of-a-rare-phenomenon-at-a-single-institution
#8
Peipei Xu, Xiaotian Xia, Meifang Li, Minggao Guo, Zhili Yang
BACKGROUND: Parathyroid cysts are relatively uncommon lesions and are often misdiagnosed. We evaluate our experience in the diagnosis of and therapy to correct parathyroid cystic lesions. METHODS: We retrospectively reviewed a series of 32 patients with parathyroid cysts who were admitted to our department between July 2011 and November 2016. Clinical pathological features of the patients, including age, gender, location, size, ultrasonography, histopathology, surgery, and follow-up, were analyzed...
February 6, 2018: BMC Surgery
https://www.readbyqxmd.com/read/29405252/randomized-clinical-trial-of-intraoperative-parathyroid-gland-angiography-with-indocyanine-green-fluorescence-predicting-parathyroid-function-after-thyroid-surgery
#9
J Vidal Fortuny, S M Sadowski, V Belfontali, S Guigard, A Poncet, F Ris, W Karenovics, F Triponez
BACKGROUND: Hypoparathyroidism, the most common complication after thyroid surgery, leads to hypocalcaemia and significant medical problems. An RCT was undertaken to determine whether intraoperative parathyroid gland angiography with indocyanine green (ICG) could predict postoperative hypoparathyroidism, and obviate the need for systematic blood tests and oral calcium supplementation. METHODS: Between September 2014 and February 2016, patients who had at least one well perfused parathyroid gland on ICG angiography were randomized to receive standard follow-up (measurement of calcium and parathyroid hormone (PTH) on postoperative day (POD) 1 and systematic supplementation with calcium and vitamin D; control group) or no supplementation and no blood test on POD 1 (intervention group)...
February 6, 2018: British Journal of Surgery
https://www.readbyqxmd.com/read/29404934/biochemical-and-pathologic-factors-affecting-technetium-99m-methoxyisobutylisonitrile-imaging-results-in-patients-with-primary-hyperparathyroidism
#10
Aysenur Ozderya, Sule Temizkan, Aylin Ege Gul, Sule Ozugur, Kenan Cetin, Kadriye Aydin
OBJECTIVE: Technetium 99 m methoxyisobutylisonitrile (Tc-99m MIBI) scintigraphy represents the most commonly utilized imaging modality for the detection of the diseased gland in patients with primary hyperparathyroidism (PHPT). In this study, we aimed to identify potential biological factors with an impact on MIBI sensitivity. METHODS: A total of 147 patients with surgically confirmed parathyroid adenomas were assessed retrospectively. Data including medical history, biochemical and hormonal measurements, cervical US, Tc-99m MIBI scans as well as pathology reports were retrieved and recorded...
February 5, 2018: Annals of Nuclear Medicine
https://www.readbyqxmd.com/read/29404903/pre-operative-localization-of-abnormal-parathyroid-tissue-by-99m-tc-sestamibi-in-primary-hyperparathyroidism-using-four-quadrant-site-analysis-an-evaluation-of-the-predictive-value-of-vitamin-d-deficiency
#11
Yu-Kwang Donovan Tay, Randy Yeh, Jennifer H Kuo, Catherine McManus, James A Lee, John P Bilezikian
CONTEXT: Accurate preoperative localization of abnormal parathyroid tissue aids importantly in minimally invasive parathyroidectomy in patients with primary hyperparathyroidism. Vitamin D deficiency may possibly influence the success and characteristics of pre-operative localization because it is associated with more active disease and possibly larger adenomas. This could increase the sensitivity of the sestamibi to identify abnormal parathyroid tissue, but earlier reports are conflicting...
February 5, 2018: Endocrine
https://www.readbyqxmd.com/read/29398031/does-the-number-of-parathyroid-glands-autotransplanted-affect-the-incidence-of-hypoparathyroidism-and-recovery-of-parathyroid-function
#12
Anping Su, Yanping Gong, Wenshuang Wu, Rixiang Gong, Zhihui Li, Jingqiang Zhu
BACKGROUND: The relationship between the number of parathyroid glands autotransplanted and hypoparathyroidism as well as recovery of parathyroid function is not understood fully. The aim was to ascertain whether the number of autotransplanted glands affected the incidence of hypoparathyroidism and recovery of parathyroid function in long-term follow-up after thyroidectomy. METHODS: A retrospective cohort study included all patients with papillary thyroid carcinoma who underwent first-time total thyroidectomy with central neck dissection between June 2012 and June 2015...
February 2, 2018: Surgery
https://www.readbyqxmd.com/read/29394551/-laparoscopic-total-gastrectomy-ltg-in-patient-with-multiple-gastric-neuroendocrine-tumor-related-to-multiple-endocrine-neoplasia-type-1-two-case-reports
#13
Yoshihiro Mori, Tatsuya Yamada, Kazuhisa Ehara, Shu Arai, Yumiko Kageyama, Yoshiyuki Kawashima, Satoshi Nomura, Yukinori Kamio, Daiji Oka, Takashi Fukuda, Hirohiko Sakamoto, Hanako Oba, Masafumi Kurosumi, Kiwamu Akagi
We herein report 2 cases of laparoscopic total gastrectomy(LTG)in patient with multiple gastric neuroendocrine tumor (NET)related to multiple endocrine neoplasia type 1(MEN1). Case 1: A 66-year-old female was diagnosed with multiple gastric NET. There was no finding of any other tumor, and parathyroid function was normal. She underwent LTG. Case 2: A 58-year-old female was diagnosed with multiple gastric NET. The patient had a previous history of surgery for pituitary gland tumor. There was no finding of any other tumor, and parathyroid function was normal...
November 2017: Gan to Kagaku Ryoho. Cancer & Chemotherapy
https://www.readbyqxmd.com/read/29381784/thymic-pth-increases-after-thyroparathyroidectomy-in-c57bl6-kalwrij-mice
#14
Maurizio Zangari, Hanna Yoo, Ikjae Shin, Bumjun Kim, Ricky Edmonson, Gareth J Morgan, Larry J Suva, Donghoon Yoon
We previously reported a significant correlation between serum parathyroid hormone (PTH) levels and the myeloma response to proteasome inhibition suggesting crucial role for the PTH receptor 1 system in the control of myeloma tumor growth. While investigating the role of PTH in the anti-myeloma effect, the recovery of serum PTH levels after thyroparathyroidectomy (TPTX) was observed. Although the presence of thymus-derived PTH has been reported previously, the existence or role of thymic PTH in the serum remains controversial...
January 25, 2018: Endocrinology
https://www.readbyqxmd.com/read/29372312/benefit-of-18f-fluorocholine-pet-imaging-in-parathyroid-surgery
#15
G F Huber, M Hüllner, C Schmid, A Brunner, B Sah, D Vetter, P A Kaufmann, G K von Schulthess
OBJECTIVES: To assess the additional diagnostic value of 18F-fluorocholine PET imaging in preoperative localization of pathologic parathyroid glands in clinically manifest hyperparathyroidism in case of negative or conflicting ultrasound and scintigraphy results. METHODS: A retrospective, single-institution study of 26 patients diagnosed with hyperparathyroidism. In cases where ultrasound and scintigraphy failed to detect the location of an adenoma in order to allow a focused surgical approach, an additional 18F-fluorocholine PET scan was performed and its results were compared with the intraoperative findings...
January 25, 2018: European Radiology
https://www.readbyqxmd.com/read/29372030/changes-in-expression-of-klotho-affect-physiological-processes-diseases-and-cancer
#16
REVIEW
Nguyen Thi Xuan, Nong Van Hai
Klotho (KL) encodes a single-pass transmembrane protein and is predominantly expressed in the kidney, parathyroid glands, and choroid plexus. Genetic studies on the KL gene have revealed that DNA hypermethylation is one of the major risk factors for aging, diseases, and cancer. Besides, KL exerts anti-inflammatory and anti-tumor effects by regulating signaling pathways and the expression of target genes. KL participates in modulation of the insulin/insulin-like growth factor-1 (IGF-1) signaling, which induces the growth hormone (GH) secretion...
January 2018: Iranian Journal of Basic Medical Sciences
https://www.readbyqxmd.com/read/29370544/evaluation-criteria-and-surgical-technique-for-transoral-access-to-the-thyroid-gland-experimental-study
#17
Alexander M Shulutko, Vasiliy I Semikov, Elkhan G Osmanov, Sergey E Gryaznov, Anna V Gorbacheva, Alla R Patalova, Gaukhar T Mansurova, Airazat M Kazaryan
BACKGROUND: The development of endoscopic techniques motivated surgeons to search for alternative and more cosmetic approaches for thyroid and parathyroid surgery. Several variations of transoral access to the anterior neck areas were applied in recent years. One of them is a premandibular access proposed by Nakajo et al, it is performed through the oral vestibule by creating the working space by means of the lifting method. MATERIALS AND METHODS: Nineteen unfixed human cadavers were used to develop the endoscopic access to the thyroid gland and surgical techniques of its resection...
January 25, 2018: Journal of Investigative Surgery: the Official Journal of the Academy of Surgical Research
https://www.readbyqxmd.com/read/29364016/impact-of-laparoscopic-approach-in-emergency-major-abdominal-surgery-single-centre-analysis-of-748-consecutive-cases
#18
P H Pucher, N C Carter, B C Knight, Skc Toh, V Tucker, S J Mercer
Background Minimally invasive parathyroidectomy (MIP) for primary hyperparathyroidism is dependent upon accurate prediction of single-gland disease on the basis of preoperative imaging and biochemistry. The aims of this study were to validate currently available predictive models of single-gland disease in two UK cohorts and to determine if these models can facilitate MIP. Methods This is a retrospectively cohort study of 624 patients who underwent parathyroidectomy for primary hyperparathyroidism in two centres between July 2008 and December 2013...
January 24, 2018: Annals of the Royal College of Surgeons of England
https://www.readbyqxmd.com/read/29359203/rare-undiagnosed-primary-amyloidosis-unmasked-during-surgical-treatment-of-primary-hyperparathyroidism-a-case-report
#19
Kathleen C Gallagher, Ariana B Geromes, John Stokes, India A Reddy, James S Lewis, Naira Baregamian
Primary amyloidosis (PA) is a protein deposition disorder that presents with localized or multisystemic disease. The incidence is low in the general public, ranging from three to eight cases per million, and with nonspecific presenting symptoms typically occurring later in life. Due to late presentation, substantial and irreversible damage has usually already occurred by the time of the diagnosis. However, if inadvertent diagnosis occurs before irreversible damage has taken place, as it did in the following case, some patients may benefit from the disease-arresting treatment...
February 1, 2018: Journal of the Endocrine Society
https://www.readbyqxmd.com/read/29356201/novel-method-to-save-the-parathyroid-gland-during-thyroidectomy-subcapsular-saline-injection
#20
June Young Choi, Hyeong Won Yu, In Eui Bae, Jong-Kyu Kim, Chan Yong Seong, Jin Wook Yi, Young Jun Chai, Su-Jin Kim, Kyu Eun Lee
BACKGROUND: Saving the parathyroid gland during thyroidectomy remains challenging. Subcapsular saline injection (SCASI) was developed in February 2015. Its ability to spare the parathyroid gland was assessed. METHODS: All consecutive patients who underwent total thyroidectomy with or without neck lymph node dissection in 2013-2015 were included in this retrospective cohort study. Patients were divided into the SCASI and non-SCASI groups. Serum parathyroid hormone (PTH) levels were measured on day 1 and 6 months after surgery...
January 22, 2018: Head & Neck
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