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Wound Hazard Cox

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https://www.readbyqxmd.com/read/28073665/predictive-ability-of-the-society-for-vascular-surgery-wound-ischemia-and-foot-infection-wifi-classification-system-after-first-time-lower-extremity-revascularizations
#1
Jeremy D Darling, John C McCallum, Peter A Soden, Raul J Guzman, Mark C Wyers, Allen D Hamdan, Hence J Verhagen, Marc L Schermerhorn
OBJECTIVE: The Society for Vascular Surgery (SVS) Wound, Ischemia and foot Infection (WIfI) classification system was proposed to predict 1-year amputation risk and potential benefit from revascularization. Our goal was to evaluate the predictive ability of this scale in a real-world selection of patients undergoing a first-time lower extremity revascularization for chronic limb-threatening ischemia (CLTI). METHODS: From 2005 to 2014, 1336 limbs underwent a first-time lower extremity revascularization for CLTI, of which 992 had sufficient data to classify all three WIfI components (wound, ischemia, and foot infection)...
January 7, 2017: Journal of Vascular Surgery
https://www.readbyqxmd.com/read/28063868/distinct-wound-healing-and-quality-of-life-outcomes-in-subgroups-of-patients-with-venous-leg-ulcers-with-different-symptom-cluster-experiences
#2
Kathleen Finlayson, Christine Miaskowski, Kimberly Alexander, Wei-Hong Liu, Bradley Aouizerat, Christina Parker, Dianne Maresco-Pennisi, Helen Edwards
CONTEXT: Adults with venous leg ulcers frequently experience multiple symptoms which may influence quality of life (QOL). OBJECTIVES: To identify patient subgroups based on their experience with a pain-depression-fatigue-sleep disturbance (PDFS) symptom cluster and to identify differences in patient characteristics, as well as wound healing and quality of life outcomes between the subgroups. METHODS: Secondary data analysis from previous longitudinal studies of 247 patients with venous leg ulcers...
January 4, 2017: Journal of Pain and Symptom Management
https://www.readbyqxmd.com/read/28002368/effect-of-body-mass-index-on-reoperation-and-complications-after-total-knee-arthroplasty
#3
Eric R Wagner, Atul F Kamath, Kristin Fruth, William S Harmsen, Daniel J Berry
BACKGROUND: High body mass index (BMI) is associated with increased rates of complications after total knee arthroplasty. To date, to our knowledge, studies have examined risk as a dichotomous variable using specific BMI thresholds. The purpose of this investigation was to quantify implant survival and the risk of common complications after total knee arthroplasty using BMI as a continuous variable. METHODS: Using prospectively collected data from our institutional total joint registry, we analyzed 22,289 consecutive knees, in 16,136 patients, treated with primary total knee arthroplasty from 1985 to 2012...
December 21, 2016: Journal of Bone and Joint Surgery. American Volume
https://www.readbyqxmd.com/read/27993696/long-term-outcomes-after-abdominal-wall-reconstruction-with-acellular-dermal-matrix
#4
Patrick B Garvey, Salvatore A Giordano, Donald P Baumann, Jun Liu, Charles E Butler
BACKGROUND: Long-term outcomes data for hernia recurrence rates following abdominal wall reconstruction (AWR) with acellular dermal matrix (ADM) are lacking. The aim of this study was to assess the long-term durability of AWR using ADM. STUDY DESIGN: We studied patients who underwent AWR with ADM at a single center in 2005-2015 with a minimum follow-up of 36 months. Hernia recurrence was the primary outcome and surgical site occurrence (SSO) was a secondary outcome...
December 16, 2016: Journal of the American College of Surgeons
https://www.readbyqxmd.com/read/27981545/long-non-coding-rna-mvih-acts-as-a-prognostic-marker-in-glioma-and-its-role-in-cell-migration-and-invasion
#5
J-J Zhuang, M Yue, Y-H Zheng, J-P Li, X-Y Dong
OBJECTIVE: High expression levels of lncRNA associated with microvascular invasion in HCC (lncRNA MVIH) were found to correlate with several solid tumors. However, little is known concerning the function of MVIH in glioma. The purpose of our study is to explore the role of lncRNA MVIH in clinical glioma samples and cell lines. PATIENTS AND METHODS: The expression levels of MVIH were analyzed in glioma surgical resection tissues and cells by RT-PCR. Additionally, the associations of MVIH expression with clinicopathological features were analyzed...
December 2016: European Review for Medical and Pharmacological Sciences
https://www.readbyqxmd.com/read/27930679/reconstruction-of-the-foot-and-ankle-using-pedicled-or-free-flaps-perioperative-flap-survival-analysis
#6
Xiucun Li, Jianli Cui, Suraj Maharjan, Laijin Lu, Xu Gong
OBJECTIVE: The purpose of this study is to determine the correlation between non-technical risk factors and the perioperative flap survival rate and to evaluate the choice of skin flap for the reconstruction of foot and ankle. METHODS: This was a clinical retrospective study. Nine variables were identified. The Kaplan-Meier method coupled with a log-rank test and a Cox regression model was used to predict the risk factors that influence the perioperative flap survival rate...
2016: PloS One
https://www.readbyqxmd.com/read/27865638/incidence-and-clinical-outcomes-of-the-slow-flow-phenomenon-after-infrapopliteal-balloon-angioplasty
#7
Takahiro Tokuda, Keisuke Hirano, Yasunari Sakamoto, Hideyuki Takimura, Norihiro Kobayashi, Motoharu Araki, Masahiro Yamawaki, Yoshiaki Ito
OBJECTIVE: This study investigated the incidence and clinical relevance of the slow-flow phenomenon after infrapopliteal balloon angioplasty. METHODS: This retrospective, single-center study included 161 consecutive patients with critical limb ischemia (173 limbs) who underwent endovascular treatment for infrapopliteal lesions between January 2012 and May 2015. The overall technical success rate was 88%. Of these lesions, 30 limbs presented with slow flow after angioplasty...
November 16, 2016: Journal of Vascular Surgery
https://www.readbyqxmd.com/read/27865036/relationship-between-opioid-treatment-and-rate-of-healing-in-chronic-wounds
#8
Victoria K Shanmugam, Kara S Couch, Sean McNish, Richard L Amdur
Opioids are routinely used analgesics in patients with chronic wounds; however the impact of opioid exposure on wound healing is poorly understood. The purpose of this study was to investigate the association between opioid exposure and wound outcome in the WE-HEAL study. This longitudinal observational study was conducted on 450 subjects enrolled in the WE-HEAL biorepository. Data were collected prospectively including baseline characteristics, pain score, longitudinal opioid exposure, and total wound surface area (tWSA)...
November 16, 2016: Wound Repair and Regeneration
https://www.readbyqxmd.com/read/27836001/galectin-1-from-cancer-associated-fibroblasts-induces-epithelial-mesenchymal-transition-through-%C3%AE-1-integrin-mediated-upregulation-of-gli1-in-gastric-cancer
#9
Yang Chong, Dong Tang, Qingquan Xiong, Xuetong Jiang, Chuanqi Xu, Yuqin Huang, Jie Wang, Huaicheng Zhou, Youquan Shi, Xiaoqing Wu, Daorong Wang
BACKGROUND: Gastric cancer (GC) is characterized by the excessive deposition of extracellular matrix, which is thought to contribute to this tumor's malignant behavior. Epithelial-mesenchymal transition (EMT) is regarded as a crucial contributing factor to cancer progression. Galectin-1 (Gal-1), a β-galactoside-binding protein abundantly expressed in activated cancer-associated fibroblasts (CAFs), has been reported to be involved in GC progression and metastasis by binding to β1 integrin, which, in turn, can bind to matrix proteins and activate intracellular cascades that mediate EMT...
November 11, 2016: Journal of Experimental & Clinical Cancer Research: CR
https://www.readbyqxmd.com/read/27784818/effect-of-dipeptidyl-peptidase-4-inhibitor-in-patients-undergoing-bypass-surgery
#10
Shinji Ogawa, Yasuhide Okawa, Koshi Sawada, Yoshihiro Goto, Syunsuke Fukaya, Takahiko Suzuki
OBJECTIVES: Patients with diabetes mellitus often have more complicated postoperative courses and worse outcomes after coronary artery bypass grafting than those without this condition. Dipeptidyl-peptidase-4 inhibitors are a new class of oral medication for treating type 2 diabetes mellitus. We investigated how these drugs influence the postoperative course after coronary artery bypass in patients with type 2 diabetes mellitus. METHODS: We retrospectively reviewed the clinical records of 177 patients with type 2 diabetes who has undergone coronary artery bypass surgery between 2009 and 2013; 107 were treated with dipeptidyl-peptidase-4 inhibitors postoperatively, and 70 who did not receive dipeptidyl-peptidase-4 inhibitors served as a control group...
November 2016: Asian Cardiovascular & Thoracic Annals
https://www.readbyqxmd.com/read/27758848/wound-healing-of-critical-limb-ischemia-with-tissue-loss-in-patients-on-hemodialysis
#11
Yohsuke Honda, Keisuke Hirano, Masahiro Yamawaki, Shinsuke Mori, Shigemitsu Shirai, Kenji Makino, Takahiro Tokuda, Takuro Takama, Masakazu Tsutumi, Yasunari Sakamoto, Hideyuki Takimura, Norihiro Kobayashi, Motoharu Araki, Yoshiaki Ito
We assessed wound healing in patients on hemodialysis (HD) with critical limb ischemia (CLI). This study enrolled 267 patients (including 120 patients on HD and 147 patients not on HD) who underwent endovascular therapy (EVT) for CLI. The primary endpoint was wound-healing rate at two years. Secondary endpoints were time to wound healing, wound recurrence rate, and limb salvage at two years. The percentage of male and young patients was higher in the HD patients (p < 0.01). A lower patency of the pedal arch after EVT was observed frequently in HD patients (p < 0...
October 6, 2016: Vascular
https://www.readbyqxmd.com/read/27693605/the-prognostic-significance-of-different-definitions-for-angiosome-targeted-lower-limb-revascularization
#12
Kristýna Špillerová, Fausto Biancari, Nicla Settembre, Anders Albäck, Maarit Venermo
BACKGROUND: The definition of angiosome-targeted revascularization is confusing, especially when a tissue lesion affects several angiosomes. Two different definitions of direct revascularization exist in the literature. The study aim was (1) to compare the 2 definitions of direct revascularization in patients with foot lesions involving more than one angiosome and (2) to evaluate which definition better predicts clinical outcome. METHODS: This study cohort comprises 658 patients with Rutherford 5-6 foot lesions who underwent infrapopliteal endovascular or surgical revascularization between January 2010 and July 2013...
September 29, 2016: Annals of Vascular Surgery
https://www.readbyqxmd.com/read/27667151/elevated-serum-phosphate-levels-are-associated-with-decreased-amputation-free-survival-after-interventions-for-critical-limb-ischemia
#13
Sara L Zettervall, Peter A Soden, Klaas H J Ultee, Crystal Seldon, Jinhee Oh, Kevin McGann, Marc L Schermerhorn, Raul J Guzman
OBJECTIVE: Elevated serum phosphate levels have been associated with increased risks of cardiovascular events and death in several patient populations. The effects of serum phosphate on outcomes in patients with critical limb ischemia (CLI) have not been evaluated. In this study, we assessed the effect of abnormal phosphate levels on mortality and major limb events after surgical intervention for CLI. METHODS: A retrospective review was undertaken to identify all patients at a single institution who underwent a first-time open or endovascular intervention for CLI between 2005 and 2014...
September 22, 2016: Journal of Vascular Surgery
https://www.readbyqxmd.com/read/27664086/respiratory-morbidity-after-childhood-burns-a-10-year-follow-up-study
#14
Janine M Duke, Sean M Randall, Mark W Fear, James H Boyd, Suzanne Rea, Fiona M Wood
BACKGROUND AND OBJECTIVE: The systemic responses triggered by burns and resuscitative measures may cause pulmonary damage and edema in the acute phase. These effects may occur in the absence of inhalation injury. Currently, there is a paucity of data on the recovery of the respiratory system postburn. This study aimed to examine 10-year hospital service use for respiratory morbidity in children with cutaneous burns and no smoke inhalation injury. METHODS: A population-based longitudinal study with 10-year follow-up using linked hospital and death from Western Australia for children <5 years when hospitalized for a first burn injury (n = 5290) between 1980 and 2012 and a frequency matched noninjury comparison cohort, randomly selected from Western Australia's birth registrations (n = 27 061)...
October 2016: Pediatrics
https://www.readbyqxmd.com/read/27662286/cohort-study-on-predictors-of-need-for%C3%A2-nursing-care-in-alzheimer-s-disease-an-analysis-of-healthcare-data
#15
Bernd Brüggenjürgen, Frank Andersohn, Jörg Burkowitz, Nadja Ezzat, Maren Gaudig, Stefan N Willich
BACKGROUND: The individual and societal burden of Alzheimer's disease (AD) is substantial. Identifying relevant factors deteriorating AD and inducing need for nursing care would be of high relevance for healthcare planning. OBJECTIVE: The main objective of this study was the identification of predictors of first assignment of a level of long-term care in AD, used as an approximation for disease progression. METHODS: In a retrospective cohort study using data from a large German statutory health and long-term care insurance (SHI) company, co-morbidities and drug exposure were evaluated with respect to their predictive value for disease progression (first day the amount of daily nursing care exceeded 1...
October 18, 2016: Journal of Alzheimer's Disease: JAD
https://www.readbyqxmd.com/read/27603002/combined-epidural-general-anesthesia-vs-general-anesthesia-alone-for-elective-abdominal-aortic-aneurysm-repair
#16
Amit Bardia, Akshay Sood, Feroze Mahmood, Vwaire Orhurhu, Ariel Mueller, Mario Montealegre-Gallegos, Marc R Shnider, Klaas H J Ultee, Marc L Schermerhorn, Robina Matyal
Importance: Epidural analgesia (EA) is used as an adjunct procedure for postoperative pain control during elective abdominal aortic aneurysm (AAA) surgery. In addition to analgesia, modulatory effects of EA on spinal sympathetic outflow result in improved organ perfusion with reduced complications. Reductions in postoperative complications lead to shorter convalescence and possibly improved 30-day survival. However, the effect of EA on long-term survival when used as an adjunct to general anesthesia (GA) during elective AAA surgery is unknown...
December 1, 2016: JAMA Surgery
https://www.readbyqxmd.com/read/27562787/surgical-risks-and-costs-of-care-are-greater-in-patients-who-are-super-obese-and-undergoing-tha
#17
Menachem M Meller, Nader Toossi, Mark H Gonzalez, Min-Sun Son, Edmund C Lau, Norman Johanson
BACKGROUND: Patients with morbid obesity, defined as a BMI greater than 40 kg/m(2), and super obesity, defined as a BMI greater than 50 kg/m(2), increasingly present for total hip replacement. There is disagreement in the literature whether these individuals have greater surgical risks and costs for the episode of care, and the magnitude of those risks and costs. There also is no established threshold for obesity as defined by BMI in identifying increased complications, risks, and costs of care...
November 2016: Clinical Orthopaedics and related Research
https://www.readbyqxmd.com/read/27554688/real-world-performance-of-paclitaxel-drug-eluting-bare-metal-stenting-zilver-ptx-for-the-treatment-of-femoropopliteal-occlusive-disease
#18
Kenneth Tran, Brant W Ullery, Marcus R Kret, Jason T Lee
BACKGROUND: The aim of this study was to evaluate the performance and predictors of stent failure of paclitaxel drug-eluting stents for the treatment of femoropopliteal disease. METHODS: A retrospective review of clinical and angiographic data was performed for patients treated for femoropopliteal disease with the Zilver PTX (Cook Medical, Bloomington, IN) stent by a single operator between 2012 and 2015 at a tertiary referral center. Clinical grading was determined by both Rutherford classification and the Society for Vascular Surgery's Wound, Ischemia, and Foot Infection (WIFi) scoring system, and lesions were classified anatomically by the TransAtlantic Intersociety Consensus (TASC) II criteria...
January 2017: Annals of Vascular Surgery
https://www.readbyqxmd.com/read/27488491/effect-of-time-to-operation-on-mortality-for-hypotensive-patients-with-gunshot-wounds-to-the-torso-the-golden-10-minutes
#19
Jonathan P Meizoso, Juliet J Ray, Charles A Karcutskie, Casey J Allen, Tanya L Zakrison, Gerd D Pust, Tulay Koru-Sengul, Enrique Ginzburg, Louis R Pizano, Carl I Schulman, Alan S Livingstone, Kenneth G Proctor, Nicholas Namias
INTRODUCTION: Timely hemorrhage control is paramount in trauma; however, a critical time interval from emergency department arrival to operation for hypotensive gunshot wound (GSW) victims is not established. We hypothesize that delaying surgery for more than 10 minutes from arrival increases all-cause mortality in hypotensive patients with GSW. METHODS: Data of adults (n = 309) with hypotension and GSW to the torso requiring immediate operation from January 2004 to September 2013 were retrospectively reviewed...
October 2016: Journal of Trauma and Acute Care Surgery
https://www.readbyqxmd.com/read/27354323/time-to-wound-healing-and-major-adverse-limb-events-in-patients-with-critical-limb-ischemia-treated-with-endovascular-revascularization
#20
Grant W Reed, Negar Salehi, Pejman R Giglou, Rami Kafa, Umair Malik, Michael Maier, Mehdi H Shishehbor
PURPOSE: There are few studies that quantify the impact of time to wound healing on outcomes after endovascular revascularization of critical limb ischemia (CLI). MATERIAL AND METHODS: In this retrospective study, 179 patients with CLI and tissue loss were assessed for adverse events after endovascular therapy. Associations between time to wound healing and outcomes were determined via Cox proportional hazards analysis. The long-term probability of events was assessed with Kaplan-Meier analysis...
June 25, 2016: Annals of Vascular Surgery
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