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Cervical cancer epidemiology

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https://www.readbyqxmd.com/read/27876223/monitoring-of-organochlorine-pesticides-in-blood-of-women-with-uterine-cervix-cancer
#1
Ángel G Polanco Rodríguez, M Inmaculada Riba López, T Ángel DelValls Casillas, J Alfredo Araujo León, Olfa Mahjoub, Anjan Kumar Prusty
In Yucatan, Mexico, chronic exposure of Mayan population to pesticides is expected as about 30 per cent are drinking polluted water. Residues of organochlorine pesticides (OCP) were monitored in 18 municipalities of Yucatan with high mortality rates due to uterine cervix cancer. 70 blood samples collected from Mayan women living in livestock, agricultural and metropolitan area were analyzed for OCP. Solid Phase Extraction was performed on C18 cartridges and analyzed by Gas Chromatography with Electron Capture Detector...
November 18, 2016: Environmental Pollution
https://www.readbyqxmd.com/read/27836494/associations-between-vaginal-infections-and-potential-high-risk-and-high-risk-human-papillomavirus-genotypes-in-female-sex-workers-in-western-kenya
#2
Sonia Menon, Davy Vanden Broeck, Rodolfo Rossi, Emiliono Ogbe, Stacy Harmon, Hillary Mabeya
PURPOSE: Infection with and persistence of high-risk human papillomavirus (HR HPV) are the strongest risk factors for cervical cancer. Little is known about the prevalence and role of concurrent sexually transmitted infections (STIs) found in HPV-infected female sex workers (FSW) in Africa. This study purports to test our a priori hypotheses that STIs are associated with genotypes pertaining to the α-group species 9. The objectives were to determine the prevalence of bacterial vaginosis (BV), Trichomonas vaginalis, and Candida spp in FSW, the association between these STIs and the prevalence of any potential HR and HR HPV genotypes in FSWs...
November 8, 2016: Clinical Therapeutics
https://www.readbyqxmd.com/read/27836371/predictors-of-nodal-metastasis-in-pediatric-differentiated-thyroid-cancer
#3
Jina Kim, Zhifei Sun, Mohamed A Adam, Obinna O Adibe, Henry E Rice, Sanziana A Roman, Elisabeth T Tracy
BACKGROUND/PURPOSE: There are limited data identifying risk factors for nodal metastasis in children with differentiated thyroid cancer. METHODS: The 1998-2011 Surveillance, Epidemiology, and End Results Program database was queried for patients ≤18years of age diagnosed with differentiated thyroid cancer who underwent nodal examination. Patients were grouped by absence or presence of nodal metastasis. Multivariable logistic regression methods were used to identify independent risk factors for nodal metastasis...
October 27, 2016: Journal of Pediatric Surgery
https://www.readbyqxmd.com/read/27821079/comparison-of-dna-testing-strategies-in-monitoring-human-papillomavirus-infection-prevalence-through-simulation
#4
Carol Y Lin, Ling Li
BACKGROUND: HPV DNA diagnostic tests for epidemiology monitoring (research purpose) or cervical cancer screening (clinical purpose) have often been considered separately. Women with positive Linear Array (LA) polymerase chain reaction (PCR) research test results typically are neither informed nor referred for colposcopy. Recently, a sequential testing by using Hybrid Capture 2 (HC2) HPV clinical test as a triage before genotype by LA has been adopted for monitoring HPV infections. Also, HC2 has been reported as a more feasible screening approach for cervical cancer in low-resource countries...
November 7, 2016: BMC Infectious Diseases
https://www.readbyqxmd.com/read/27806689/functional-variants-of-human-papillomavirus-type-16-demonstrate-host-genome-integration-and-transcriptional-alterations-corresponding-to-their-unique-cancer-epidemiology
#5
Robert Jackson, Bruce A Rosa, Sonia Lameiras, Sean Cuninghame, Josee Bernard, Wely B Floriano, Paul F Lambert, Alain Nicolas, Ingeborg Zehbe
BACKGROUND: Human papillomaviruses (HPVs) are a worldwide burden as they are a widespread group of tumour viruses in humans. Having a tropism for mucosal tissues, high-risk HPVs are detected in nearly all cervical cancers. HPV16 is the most common high-risk type but not all women infected with high-risk HPV develop a malignant tumour. Likely relevant, HPV genomes are polymorphic and some HPV16 single nucleotide polymorphisms (SNPs) are under evolutionary constraint instigating variable oncogenicity and immunogenicity in the infected host...
November 2, 2016: BMC Genomics
https://www.readbyqxmd.com/read/27797234/life-style-habits-in-a-high-risk-area-for-upper-gastrointestinal-cancers-a-population-based-study-from-shanxi-china
#6
Yi-Kun Cheng, Shang-Man Yao, Yi-Ran Xu, Run-Gui Niu
BACKGROUND: Cancer is a burden on humanity and ranks as a leading cause of morbidity and mortality in China. Shanxi province has its unique cancer patterns and the burden is increasing. In this study, we aimed to assess the pattern of dietary habits and life-style in Shanxi, a high-risk area for upper gastrointestinal cancers in China and further evaluate the trends in cancer incidence and mortality based on registered data. MATERIALS AND METHODS: Data on lifestyle, diet, physical activity were obtained from the household health survey at Zhongyang from 2013 to 2015...
2016: Asian Pacific Journal of Cancer Prevention: APJCP
https://www.readbyqxmd.com/read/27777126/design-of-a-long-term-follow-up-effectiveness-immunogenicity-and-safety-study-of-women-who-received-the-9-valent-human-papillomavirus-vaccine
#7
Alain Luxembourg, Susanne K Kjaer, Mari Nygard, Misoo C Ellison, Thomas Group, J Brooke Marshall, David Radley, Alfred Saah
The 9-valent human papillomavirus (HPV) (9vHPV) vaccine targets four HPV types (6/11/16/18) also covered by the quadrivalent HPV (qHPV) vaccine and five additional types (31/33/45/52/58). Vaccine efficacy to prevent HPV infection and disease was established in a Phase III clinical study in women 16-26years of age. A long-term follow-up (LTFU) study has been initiated as an extension of the Phase III clinical study to assess effectiveness of the 9vHPV vaccine up to at least 14years after the start of vaccination...
October 21, 2016: Contemporary Clinical Trials
https://www.readbyqxmd.com/read/27775261/the-epidemiologic-status-of-gynecologic-cancer-in-thailand
#8
Sarikapan Wilailak, Nuttapong Lertchaipattanakul
Between the years of 2010-2012, it was estimated there were a total of 112,392 new cases of cancers in Thailand, thus, the total age-standardized rate (ASR) per 100,000 is 137.6. In regards to the most prevalent types of cancer in female, breast cancer has the highest ASR, followed by cervical cancer (ASR=14.4); liver and bile duct cancer; colon and rectum cancer; trachea, bronchus and lung cancer; ovarian cancer (ASR=6.0); thyroid cancer; non-Hodgkin lymphoma and uterine cancer (ASR=4.3). The trend of cervical cancer in Thailand is decreasing, one key factor in making this possible was the employment of dual tract strategy (Pap smear and visual inspection with acetic acid [VIA]) by the government in 2005...
November 2016: Journal of Gynecologic Oncology
https://www.readbyqxmd.com/read/27771695/the-biological-impact-of-genomic-diversity-in-cervical-cancer-development
#9
Cristina Mendes de Oliveira, José Eduardo Levi
Human papillomaviruses (HPVs) are the etiologic agents of cervical cancer, the unique human neoplasia that has one single necessary cause. The diversity of HPVs is well described, with 200 HPV types existing as distinct taxonomic units and each receiving an Arabic number. On a clinical basis, they are usually grouped by their site of occurrence and disease associations. Those types inhabiting the anogenital mucosa are more intensively studied and further divided into cancer-associated HPVs, which are termed 'high risk', while those linked to benign proliferative lesions are assigned as 'low risk'...
October 22, 2016: Acta Cytologica
https://www.readbyqxmd.com/read/27770526/genotypic-distribution-of-hpv-among-women-of-reproductive-age-in-georgia
#10
M Butsashvili, M Kajaia, M Kochlamazashvili, M Zarandia, T Gagua, D Meskhishvili, N Avaliani, G Kamkamidze
Of the 100 types of human papillomaviruses (HPV), approximately 35 infect the genital tract. The viruses are categorized as "high risk" and "low risk" depending on whether they are known to cause cancer or not. Cervical cancer is an important cause of cancer mortality in Georgia, and worldwide. Only limited and incomplete data are available about the epidemiology of HPV infection and related molecular and cellular changes in Georgia. Objectives of our study included the estimation of the prevalence and the distribution of HPV genotypes among women in Georgia...
September 2016: Georgian Medical News
https://www.readbyqxmd.com/read/27764092/epidemiology-of-hpv-genotypes-among-hiv-positive-women-in-kenya-a-systematic-review-and-meta-analysis
#11
Sonia Menon, Aibibula Wusiman, Marie Claude Boily, Mbabazi Kariisa, Hillary Mabeya, Stanley Luchters, Frode Forland, Rodolfo Rossi, Steven Callens, Davy Vanden Broeck
BACKGROUND: There is a scarcity of data on the distribution of human papillomavirus (HPV) genotypes in the HIV positive population and in invasive cervical cancer (ICC) in Kenya. This may be different from genotypes found in abnormal cytology. Yet, with the advent of preventive HPV vaccines that target HPV 16 and 18, and the nonavalent vaccine targeting 90% of all ICC cases, such HPV genotype distribution data are indispensable for predicting the impact of vaccination and HPV screening on prevention...
2016: PloS One
https://www.readbyqxmd.com/read/27750272/clinical-and-epidemiological-study-of-human-papillomavirus-infection-in-women-with-systemic-lupus-erythematosus-in-eastern-brazilian-amazon
#12
Juliana Lasmar Ayres do Amaral, Marizeli Viana de Aragão Araújo, George Alberto da Silva Dias, Esther Iris Christina Freifrau von Ledebur, Juarez Antonio Simões Quaresma, Hellen Thais Fuzii
Cervical cancer, the second most common cancer affecting women in Northern Brazil, is strongly associated with human papillomavirus (HPV) infection. Diseases affecting the immune state of a patient, including autoimmune diseases like systemic lupus erythematosus (SLE), can lead to persistent HPV infection and cancer. We evaluated cervical HPV prevalence and the associated risk factors in 70 women with SLE in the city of Belém, located in Brazilian Amazon. HPV DNA was detected by PCR using primers MY9 and MY11...
August 17, 2016: Acta Reumatológica Portuguesa
https://www.readbyqxmd.com/read/27749912/increased-growth-of-a-newly-established-mouse-epithelial-cell-line-transformed-with-hpv-16-e7-in-diabetic-mice
#13
Lan He, Priscilla T Y Law, Siaw Shi Boon, Chuqing Zhang, Wendy C S Ho, Lawrence Banks, C K Wong, Juliana C N Chan, Paul K S Chan
Epidemiological evidence supports that infection with high-risk types of human papillomavirus (HPV) can interact with host and environmental risk factors to contribute to the development of cervical, oropharyngeal, and other anogenital cancers. In this study, we established a mouse epithelial cancer cell line, designated as Chinese University Papillomavirus-1 (CUP-1), from C57BL/KsJ mice through persistent expression of HPV-16 E7 oncogene. After continuous culturing of up to 200 days with over 60 passages, we showed that CUP-1 became an immortalized and transformed epithelial cell line with continuous E7 expression and persistent reduction of retinoblastoma protein (a known target of E7)...
2016: PloS One
https://www.readbyqxmd.com/read/27749369/evolving-epidemiology-of-hiv-associated-malignancies
#14
Meredith S Shiels, Eric A Engels
PURPOSE OF REVIEW: The purpose of this review is to describe the epidemiology of cancers that occur at an elevated rate among people with HIV infection in the current treatment era, including discussion of the cause of these cancers, as well as changes in cancer incidence and burden over time. RECENT FINDINGS: Rates of Kaposi sarcoma, non-Hodgkin lymphoma and cervical cancer have declined sharply in developed countries during the highly active antiretroviral therapy era, but remain elevated 800-fold, 10-fold and four-fold, respectively, compared with the general population...
January 2017: Current Opinion in HIV and AIDS
https://www.readbyqxmd.com/read/27725620/detection-of-human-papillomavirus-in-korean-breast-cancer-patients-by-real-time-polymerase-chain-reaction-and-meta-analysis-of-human-papillomavirus-and-breast-cancer
#15
Jinhyuk Choi, Chungyeul Kim, Hye Seung Lee, Yoo Jin Choi, Ha Yeon Kim, Jinhwan Lee, Hyeyoon Chang, Aeree Kim
BACKGROUND: Human papillomavirus (HPV) is a well-established oncogenic virus of cervical, anogenital, and oropharyngeal cancer. Various subtypes of HPV have been detected in 0% to 60% of breast cancers. The roles of HPV in the carcinogenesis of breast cancer remain controversial. This study was performed to determine the prevalence of HPV-positive breast cancer in Korean patients and to evaluate the possibility of carcinogenic effect of HPV on breast. METHODS: Meta-analysis was performed in 22 case-control studies for HPV infection in breast cancer...
November 2016: Journal of Pathology and Translational Medicine
https://www.readbyqxmd.com/read/27716156/an-empirical-study-of-the-underscreened-in-organised-cervical-screening-experts-focus-on-increasing-opportunity-as-a-way-of-reducing-differences-in-screening-rates
#16
Jane H Williams, Stacy M Carter
BACKGROUND: Cervical cancer disproportionately burdens disadvantaged women. Organised cervical screening aims to make cancer prevention available to all women in a population, yet screening uptake and cancer incidence and mortality are strongly correlated with socioeconomic status (SES). Reaching underscreened populations is a stated priority in many screening programs, usually with an emphasis on something like 'equity'. Equity is a poorly defined and understood concept. We aimed to explain experts' perspectives on how cervical screening programs might justifiably respond to 'the underscreened'...
October 6, 2016: BMC Medical Ethics
https://www.readbyqxmd.com/read/27711124/resources-required-for-cervical-cancer-prevention-in-low-and-middle-income-countries
#17
Nicole G Campos, Monisha Sharma, Andrew Clark, Jane J Kim, Stephen C Resch
BACKGROUND: Cervical cancer is the fourth leading cause of cancer death in women, with 85% of cases and deaths occurring in developing countries. While organized screening programs have reduced cervical cancer incidence in high-income countries through detection and treatment of precancerous lesions, the implementation of organized screening has not been effective in low-resource settings due to lack of infrastructure and limited budgets. Our objective was to estimate the cost of comprehensive primary and secondary cervical cancer prevention in low- and middle-income countries...
2016: PloS One
https://www.readbyqxmd.com/read/27646608/comparison-of-clinical-outcomes-of-squamous-cell-carcinoma-adenocarcinoma-and-adenosquamous-carcinoma-of-the-uterine-cervix-after-definitive-radiotherapy-a-population-based-analysis
#18
Juan Zhou, San-Gang Wu, Jia-Yuan Sun, Feng-Yan Li, Huan-Xin Lin, Qiong-Hua Chen, Zhen-Yu He
PURPOSE: To evaluate the clinical outcomes in patients with International Federation of Gynecology and Obstetrics (FIGO) stage I to IVA squamous cell carcinoma (SCC), adenocarcinoma (AC), and adenosquamous carcinoma (ASC) of the uterine cervix after definitive radiotherapy. METHODS: Patients with a primary diagnosis of FIGO stage I-IVA SCC, AC, and ASC of the uterine cervix who had undergone definitive beam radiation with implants or isotopes between 1988 and 2013 were identified using the Surveillance, Epidemiology, and End Results database...
September 19, 2016: Journal of Cancer Research and Clinical Oncology
https://www.readbyqxmd.com/read/27644600/hpv-and-cervical-cancer-epidemiology-current-status-of-hpv-vaccination-in-india
#19
REVIEW
Sharmila Chatterjee, Amit Chattopadhyay, Luna Samanta, Pinaki Panigrahi
Cervical cancer (CaCx) is the second most fatal cancer contributing to 14% of cancers in Indian females, which account for 25.4% and 26.5% of the global burden of CaCx prevalence and mortality, respectively. Persistent infection with high-risk human papilloma virus (HPV- strains 16 and 18) is the most important risk factor for precursors of invasive CaCx. Comprehensive prevention strategies for CaCx should include screening and HPV vaccination. Three screening modalities for CaCx are cytology, visual inspection with acetic acid, and HPV testing...
2016: Asian Pacific Journal of Cancer Prevention: APJCP
https://www.readbyqxmd.com/read/27638711/carotenoids-biochemistry-pharmacology-and-treatment
#20
Alireza Milani, Marzieh Basirnejad, Sepideh Shahbazi, Azam Bolhassani
Carotenoids and retinoids have several similarities in biological activities such as antioxidant properties, the inhibition of malignant tumor growth, and the induction of apoptosis. Supplementation with carotenoids can influence cell growth regulation, and modulate gene expression and immune response. Epidemiologic studies have shown the correlation of high carotenoid intake from food sources with reduced risk of breast, cervical, ovarian, colorectal cancers, and cardiovascular or eye diseases. Cancer chemoprevention by dietary carotenoids involves some approaches including gap junctional intercellular communication (GJIC), growth factor signaling, cell cycle progression, differentiation-related proteins, retinoid-like receptors, antioxidant response element, nuclear receptors, AP-1 transcriptional complex, Wnt/β-Catenin pathway, and inflammatory cytokines...
September 16, 2016: British Journal of Pharmacology
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