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Cervical cancer epidemiology

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https://www.readbyqxmd.com/read/28091335/high-prevalence-of-hpv-infection-in-the-remote-villages-of-french-guiana-an-epidemiological-study
#1
A Adenis, V Dufit, M Douine, F Corlin, G Ayhan, F Najioullah, V Molinie, P Brousse, G Carles, V Lacoste, R Cesaire, M Nacher
Cervical cancer is the second most frequent cancer in women in French Guiana. Studies have shown that populations living in the remote areas of the interior have early sexual debut and that multiple sexual partnerships are common. The objective of the present study was thus to determine the prevalence of human papillomavirus (HPV) infection in these areas. A study was conducted in women aged 20-65 years with previous sexual activity. Women were included on a voluntary basis after using local media and leaders to inform them of the visit of the team...
January 16, 2017: Epidemiology and Infection
https://www.readbyqxmd.com/read/28072683/knowledge-of-greek-adolescents-on-human-papilloma-virus-hpv-and-vaccination-a-national-epidemiologic-study
#2
Dennis Vaidakis, Irini Moustaki, Ioannis Zervas, Anastasia Barbouni, Kyriaki Merakou, Maria S Chrysi, George Creatsa, Theodoros Panoskaltsis
The aim of the present study was to identify the sexual behavior, attitudes, beliefs, and knowledge on sexually transmitted infections (STIs) focused on human papilloma virus (HPV) in the Greek adolescent population. The participants were 4547 adolescents, a representative sample for Greek territory with a mean age of 17 years. After written permission from Greek ministry of education each student completed a questionnaire with 36 questions. The fields covered were demographic characteristics, sexual life data, and basic knowledge on HPV...
January 2017: Medicine (Baltimore)
https://www.readbyqxmd.com/read/28070215/multiple-hpv-infections-in-female-sex-workers-in-western-kenya-implications-for-prophylactic-vaccines-within-this-sub-population
#3
Sonia Menon, Davy van den Broeck, Rodolfo Rossi, Emilomo Ogbe, Hillary Mabeya
BACKGROUND: Whilst the imputed role of High Risk (HR) HPV infection in the development of cervical lesions and cancer has been established, the high number of HPV genotypes that Female Sex workers (FSW) harbour warrants that the synergistic effects of potential HR (pHR) and HR HPV genotypes be elucidated to assess the potential impact of prophylactic vaccines. This population in Kenya also harbours a number of other vaginal infections and STIs, including bacterial vaginosis (BV), trichomonas vaginalis (TV) and candida spp...
2017: Infectious Agents and Cancer
https://www.readbyqxmd.com/read/28069334/prevalence-of-anal-infection-due-to-high-risk-human-papillomavirus-and-analysis-of-e2-gene-integrity-among-women-with-cervical-abnormalities
#4
María Del Refugio Gonzalez-Losa, Marylin Puerto-Solís, Guadalupe Ayora-Talavera, Jesús Gómez-Carvallo, Alejandra Euán-López, José I Cisneros-Cutz, Ariel Rosado-López, Jesúa Echeverría Salazar, Laura Conde-Ferráez
BACKGROUND: High-risk human papillomaviruses (HR-HPV) infection has been associated with 90% of anal cancer cases. Women with abnormal cytology are a high-risk group to develop anal neoplasia. The aim of this study is to describe the prevalence and epidemiology of HR-HPV 16, 18, 45, and 58 anal infections in women with cervical abnormalities, as well as to assess E2 gene integrity. METHODS: A cross-sectional study was performed on 311 cervical and 311 anal samples from patients with abnormal cytology in two colposcopy clinics in Yucatan, Mexico...
January 6, 2017: Enfermedades Infecciosas y Microbiología Clínica
https://www.readbyqxmd.com/read/28056826/hpv-genotypes-distribution-in-indian-women-with-and-without-cervical-carcinoma-implication-for-hpv-vaccination-program-in-odisha-eastern-india
#5
Rashmirani Senapati, Bhagyalaxmi Nayak, Shantanu Kumar Kar, Bhagirathi Dwibedi
BACKGROUND: Considering the limited cross protection offered by the current HPV vaccines, understanding the HPV genotype distribution among the different population is essential in predicting the efficacy of current vaccine and devising new vaccine strategy. The present work aimed at investigating the HPV genotypes distribution among women with and without cervical carcinoma in Odisha, Eastern India. METHODS: A total of 607 participants have been enrolled between January 2014 and June 2016...
January 5, 2017: BMC Infectious Diseases
https://www.readbyqxmd.com/read/28046025/human-papillomavirus-hpv-infection-molecular-epidemiology-genotyping-seroprevalence-and-associated-risk-factors-among-arab-women-in-qatar
#6
Asha A Elmi, Devendra Bansal, Anushree Acharya, Sini Skariah, Soha R Dargham, Laith J Abu-Raddad, Nady Mohamed-Nady, Paul Amuna, Asma A J Al-Thani, Ali A Sultan
Human Papillomavirus (HPV) infections are known to cause cervical cancer worldwide, however, limited information is currently available on prevalence, types distribution and risk factors for HPV infection in the Arab countries. We conducted a cross-sectional observational study exclusively of women of Arabic origin residing in Qatar (n = 406) who were selected from the Women's Hospital at Hamad Medical Corporation (HMC) and Health Centers of the Primary Health Care Corporation in Doha, Qatar over the period March 2013 to August 2014...
2017: PloS One
https://www.readbyqxmd.com/read/28017434/cost-effectiveness-of-increasing-cervical-cancer-screening-coverage-in-the-middle-east-an-example-from-lebanon
#7
Monisha Sharma, Muhieddine Seoud, Jane J Kim
BACKGROUND: Most cervical cancer (CC) cases in Lebanon are detected at later stages and associated with high mortality. There is no national organized CC screening program so screening is opportunistic and limited to women who can pay out-of-pocket. Therefore, a small percentage of women receive repeated screenings while most are under-or never screened. We evaluated the cost-effectiveness of increasing screening coverage and extending intervals. METHODS: We used an individual-based Monte Carlo model simulating HPV and CC natural history and screening...
December 22, 2016: Vaccine
https://www.readbyqxmd.com/read/27926642/ovarian-conservation-and-overall-survival-in-young-women-with-early-stage-cervical-cancer
#8
Koji Matsuo, Hiroko Machida, Donna Shoupe, Alexander Melamed, Laila I Muderspach, Lynda D Roman, Jason D Wright
OBJECTIVE: To identify predictors of ovarian conservation at hysterectomy and to examine the association of ovarian conservation and survival of young women with early-stage cervical cancer. METHODS: This is a retrospective cohort study using the Surveillance, Epidemiology, and End Results Program to identify hysterectomy-based surgically treated patients with stage I cervical cancer diagnosed between 1983 and 2012 (N=16,511). Multivariable models were used to identify independent factors associated with ovarian conservation...
January 2017: Obstetrics and Gynecology
https://www.readbyqxmd.com/read/27876223/monitoring-of-organochlorine-pesticides-in-blood-of-women-with-uterine-cervix-cancer
#9
Ángel G Polanco Rodríguez, M Inmaculada Riba López, T Ángel DelValls Casillas, J Alfredo Araujo León, Olfa Mahjoub, Anjan Kumar Prusty
In Yucatan, Mexico, chronic exposure of Mayan population to pesticides is expected as about 30 per cent are drinking polluted water. Residues of organochlorine pesticides (OCP) were monitored in 18 municipalities of Yucatan with high mortality rates due to uterine cervix cancer. 70 blood samples collected from Mayan women living in livestock, agricultural and metropolitan area were analyzed for OCP. Solid Phase Extraction was performed on C18 cartridges and analyzed by Gas Chromatography with Electron Capture Detector...
January 2017: Environmental Pollution
https://www.readbyqxmd.com/read/27836494/associations-between-vaginal-infections-and-potential-high-risk-and-high-risk-human-papillomavirus-genotypes-in-female-sex-workers-in-western-kenya
#10
Sonia Menon, Davy Vanden Broeck, Rodolfo Rossi, Emilomo Ogbe, Stacy Harmon, Hillary Mabeya
PURPOSE: Infection with and persistence of high-risk human papillomavirus (HR HPV) are the strongest risk factors for cervical cancer. Little is known about the prevalence and role of concurrent sexually transmitted infections (STIs) found in HPV-infected female sex workers (FSW) in Africa. This study purports to test our a priori hypotheses that STIs are associated with genotypes pertaining to the α-group species 9. The objectives were to determine the prevalence of bacterial vaginosis (BV), Trichomonas vaginalis, and Candida spp in FSW, the association between these STIs and the prevalence of any potential HR and HR HPV genotypes in FSWs...
December 2016: Clinical Therapeutics
https://www.readbyqxmd.com/read/27836371/predictors-of-nodal-metastasis-in-pediatric-differentiated-thyroid-cancer
#11
Jina Kim, Zhifei Sun, Mohamed A Adam, Obinna O Adibe, Henry E Rice, Sanziana A Roman, Elisabeth T Tracy
BACKGROUND/PURPOSE: There are limited data identifying risk factors for nodal metastasis in children with differentiated thyroid cancer. METHODS: The 1998-2011 Surveillance, Epidemiology, and End Results Program database was queried for patients ≤18years of age diagnosed with differentiated thyroid cancer who underwent nodal examination. Patients were grouped by absence or presence of nodal metastasis. Multivariable logistic regression methods were used to identify independent risk factors for nodal metastasis...
January 2017: Journal of Pediatric Surgery
https://www.readbyqxmd.com/read/27821079/comparison-of-dna-testing-strategies-in-monitoring-human-papillomavirus-infection-prevalence-through-simulation
#12
Carol Y Lin, Ling Li
BACKGROUND: HPV DNA diagnostic tests for epidemiology monitoring (research purpose) or cervical cancer screening (clinical purpose) have often been considered separately. Women with positive Linear Array (LA) polymerase chain reaction (PCR) research test results typically are neither informed nor referred for colposcopy. Recently, a sequential testing by using Hybrid Capture 2 (HC2) HPV clinical test as a triage before genotype by LA has been adopted for monitoring HPV infections. Also, HC2 has been reported as a more feasible screening approach for cervical cancer in low-resource countries...
November 7, 2016: BMC Infectious Diseases
https://www.readbyqxmd.com/read/27806689/functional-variants-of-human-papillomavirus-type-16-demonstrate-host-genome-integration-and-transcriptional-alterations-corresponding-to-their-unique-cancer-epidemiology
#13
Robert Jackson, Bruce A Rosa, Sonia Lameiras, Sean Cuninghame, Josee Bernard, Wely B Floriano, Paul F Lambert, Alain Nicolas, Ingeborg Zehbe
BACKGROUND: Human papillomaviruses (HPVs) are a worldwide burden as they are a widespread group of tumour viruses in humans. Having a tropism for mucosal tissues, high-risk HPVs are detected in nearly all cervical cancers. HPV16 is the most common high-risk type but not all women infected with high-risk HPV develop a malignant tumour. Likely relevant, HPV genomes are polymorphic and some HPV16 single nucleotide polymorphisms (SNPs) are under evolutionary constraint instigating variable oncogenicity and immunogenicity in the infected host...
November 2, 2016: BMC Genomics
https://www.readbyqxmd.com/read/27797234/life-style-habits-in-a-high-risk-area-for-upper-gastrointestinal-cancers-a-population-based-study-from-shanxi-china
#14
Yi-Kun Cheng, Shang-Man Yao, Yi-Ran Xu, Run-Gui Niu
BACKGROUND: Cancer is a burden on humanity and ranks as a leading cause of morbidity and mortality in China. Shanxi province has its unique cancer patterns and the burden is increasing. In this study, we aimed to assess the pattern of dietary habits and life-style in Shanxi, a high-risk area for upper gastrointestinal cancers in China and further evaluate the trends in cancer incidence and mortality based on registered data. MATERIALS AND METHODS: Data on lifestyle, diet, physical activity were obtained from the household health survey at Zhongyang from 2013 to 2015...
2016: Asian Pacific Journal of Cancer Prevention: APJCP
https://www.readbyqxmd.com/read/27777126/design-of-a-long-term-follow-up-effectiveness-immunogenicity-and-safety-study-of-women-who-received-the-9-valent-human-papillomavirus-vaccine
#15
Alain Luxembourg, Susanne K Kjaer, Mari Nygard, Misoo C Ellison, Thomas Group, J Brooke Marshall, David Radley, Alfred Saah
The 9-valent human papillomavirus (HPV) (9vHPV) vaccine targets four HPV types (6/11/16/18) also covered by the quadrivalent HPV (qHPV) vaccine and five additional types (31/33/45/52/58). Vaccine efficacy to prevent HPV infection and disease was established in a Phase III clinical study in women 16-26years of age. A long-term follow-up (LTFU) study has been initiated as an extension of the Phase III clinical study to assess effectiveness of the 9vHPV vaccine up to at least 14years after the start of vaccination...
January 2017: Contemporary Clinical Trials
https://www.readbyqxmd.com/read/27775261/the-epidemiologic-status-of-gynecologic-cancer-in-thailand
#16
Sarikapan Wilailak, Nuttapong Lertchaipattanakul
Between the years of 2010-2012, it was estimated there were a total of 112,392 new cases of cancers in Thailand, thus, the total age-standardized rate (ASR) per 100,000 is 137.6. In regards to the most prevalent types of cancer in female, breast cancer has the highest ASR, followed by cervical cancer (ASR=14.4); liver and bile duct cancer; colon and rectum cancer; trachea, bronchus and lung cancer; ovarian cancer (ASR=6.0); thyroid cancer; non-Hodgkin lymphoma and uterine cancer (ASR=4.3). The trend of cervical cancer in Thailand is decreasing, one key factor in making this possible was the employment of dual tract strategy (Pap smear and visual inspection with acetic acid [VIA]) by the government in 2005...
November 2016: Journal of Gynecologic Oncology
https://www.readbyqxmd.com/read/27771695/the-biological-impact-of-genomic-diversity-in-cervical-cancer-development
#17
Cristina Mendes de Oliveira, José Eduardo Levi
Human papillomaviruses (HPVs) are the etiologic agents of cervical cancer, the unique human neoplasia that has one single necessary cause. The diversity of HPVs is well described, with 200 HPV types existing as distinct taxonomic units and each receiving an Arabic number. On a clinical basis, they are usually grouped by their site of occurrence and disease associations. Those types inhabiting the anogenital mucosa are more intensively studied and further divided into cancer-associated HPVs, which are termed 'high risk', while those linked to benign proliferative lesions are assigned as 'low risk'...
2016: Acta Cytologica
https://www.readbyqxmd.com/read/27770526/genotypic-distribution-of-hpv-among-women-of-reproductive-age-in-georgia
#18
M Butsashvili, M Kajaia, M Kochlamazashvili, M Zarandia, T Gagua, D Meskhishvili, N Avaliani, G Kamkamidze
Of the 100 types of human papillomaviruses (HPV), approximately 35 infect the genital tract. The viruses are categorized as "high risk" and "low risk" depending on whether they are known to cause cancer or not. Cervical cancer is an important cause of cancer mortality in Georgia, and worldwide. Only limited and incomplete data are available about the epidemiology of HPV infection and related molecular and cellular changes in Georgia. Objectives of our study included the estimation of the prevalence and the distribution of HPV genotypes among women in Georgia...
September 2016: Georgian Medical News
https://www.readbyqxmd.com/read/27764092/epidemiology-of-hpv-genotypes-among-hiv-positive-women-in-kenya-a-systematic-review-and-meta-analysis
#19
Sonia Menon, Aibibula Wusiman, Marie Claude Boily, Mbabazi Kariisa, Hillary Mabeya, Stanley Luchters, Frode Forland, Rodolfo Rossi, Steven Callens, Davy Vanden Broeck
BACKGROUND: There is a scarcity of data on the distribution of human papillomavirus (HPV) genotypes in the HIV positive population and in invasive cervical cancer (ICC) in Kenya. This may be different from genotypes found in abnormal cytology. Yet, with the advent of preventive HPV vaccines that target HPV 16 and 18, and the nonavalent vaccine targeting 90% of all ICC cases, such HPV genotype distribution data are indispensable for predicting the impact of vaccination and HPV screening on prevention...
2016: PloS One
https://www.readbyqxmd.com/read/27750272/clinical-and-epidemiological-study-of-human-papillomavirus-infection-in-women-with-systemic-lupus-erythematosus-in-eastern-brazilian-amazon
#20
Juliana Lasmar Ayres do Amaral, Marizeli Viana de Aragão Araújo, George Alberto da Silva Dias, Esther Iris Christina Freifrau von Ledebur, Juarez Antonio Simões Quaresma, Hellen Thais Fuzii
Cervical cancer, the second most common cancer affecting women in Northern Brazil, is strongly associated with human papillomavirus (HPV) infection. Diseases affecting the immune state of a patient, including autoimmune diseases like systemic lupus erythematosus (SLE), can lead to persistent HPV infection and cancer. We evaluated cervical HPV prevalence and the associated risk factors in 70 women with SLE in the city of Belém, located in Brazilian Amazon. HPV DNA was detected by PCR using primers MY9 and MY11...
August 17, 2016: Acta Reumatológica Portuguesa
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