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Cervical cancer epidemiology

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https://www.readbyqxmd.com/read/29454092/analysis-of-human-papillomavirus-16-e6-e7-genes-and-long-control-region-in-cervical-samples-from-uruguayan-women
#1
Viviana Ramas, Santiago Mirazo, Sylvia Bonilla, Dora Ruchansky, Juan Arbiza
OBJECTIVE: This study aims to investigate the HPV16 variant distribution by sequence analyses of E6, E7 oncogenes and the Long Control Region (LCR), from cervical cells collected from Uruguayan women, and to reconstruct the phylogenetic relationships among variants. METHODS: Forty-seven HPV16 variants, obtained from women with HSIL, LSIL, ASCUS and NILM cytological classes were analyzed for LCR and 12 were further studied for E6 and E7. Detailed sequence comparison, genetic heterogeneity analyses and phylogenetic reconstruction were performed...
February 14, 2018: Gene
https://www.readbyqxmd.com/read/29447263/insurance-status-and-cancer-treatment-mediate-the-association-between-race-ethnicity-and-cervical-cancer-survival
#2
Sarah C Markt, Tianyu Tang, Angel M Cronin, Ingrid T Katz, Brooke E Howitt, Neil S Horowitz, Larissa J Lee, Alexi A Wright
Cervical cancer outcomes remain poor among disadvantaged populations, including ethnic minorities, low-income, and underinsured women. The aim of this study was to evaluate the mechanisms that underlie the observed association between race/ethnicity and cervical cancer survival. We identified 13,698 women, ages 21 to 64 years, diagnosed with stages I-III primary cervical cancer between 2007-2013 in Surveillance, Epidemiology, and End Results (SEER). Multivariable Cox proportional hazards regression models evaluated associations between race/ethnicity (Non-Hispanic White, Non-Hispanic Black, Hispanic, Other) and cervical cancer-specific mortality...
2018: PloS One
https://www.readbyqxmd.com/read/29441569/epidemiologic-associations-of-hpv-positive-oropharyngeal-cancer-and-pre-cancerous-cervical-lesions
#3
M M Rietbergen, A A J D van Bokhoven, B I Lissenberg-Witte, D A M Heideman, C R Leemans, R H Brakenhoff, E Bloemena
PURPOSE: Human papillomavirus (HPV)- induced oropharyngeal squamous cell carcinoma (OPSCC) is still increasing worldwide. We aimed to investigate if the HPV-prevalence of OPSCC in the Netherlands is rising as well, especially in female patients. In addition, we evaluated the association between HPV-positive OPSCC and suspicious Pap results of the cervix in these female patients. PATIENTS AND METHODS: Patients with OPSCC treated in the period 2000-2015 at the VU University Medical Center Amsterdam, were included (n=926)...
February 14, 2018: International Journal of Cancer. Journal International du Cancer
https://www.readbyqxmd.com/read/29438321/the-intersection-of-hpv-epidemiology-genomics-and-mechanistic-studies-of-hpv-mediated-carcinogenesis
#4
Lisa Mirabello, Megan A Clarke, Chase W Nelson, Michael Dean, Nicolas Wentzensen, Meredith Yeager, Michael Cullen, Joseph F Boland, Mark Schiffman, Robert D Burk
Of the ~60 human papillomavirus (HPV) genotypes that infect the cervicovaginal epithelium, only 12-13 "high-risk" types are well-established as causing cervical cancer, with HPV16 accounting for over half of all cases worldwide. While HPV16 is the most important carcinogenic type, variants of HPV16 can differ in their carcinogenicity by 10-fold or more in epidemiologic studies. Strong genotype-phenotype associations embedded in the small 8-kb HPV16 genome motivate molecular studies to understand the underlying molecular mechanisms...
February 13, 2018: Viruses
https://www.readbyqxmd.com/read/29427549/linking-type-2-diabetes-and-gynecological-cancer-an-introductory-overview
#5
REVIEW
Emanuela Anastasi, Tiziana Filardi, Sara Tartaglione, Andrea Lenzi, Antonio Angeloni, Susanna Morano
Type 2 diabetes (T2D) is a chronic disease with a growing prevalence and a leading cause of death in many countries. Several epidemiological studies observed an association between T2D and increased risk of many types of cancer, such as gynecologic neoplasms (endometrial, cervical, ovarian and vulvar cancer). Insulin resistance, chronic inflammation and high free ovarian steroid hormones are considered the possible mechanisms behind this complex relationship. A higher risk of endometrial cancer was observed in T2D, even though this association largely attenuated after adjusting for obesity...
February 10, 2018: Clinical Chemistry and Laboratory Medicine: CCLM
https://www.readbyqxmd.com/read/29424085/achieving-public-and-global-health-competencies-a-teaching-case-study-of-botswana-s-cervical-cancer-screening-program
#6
Harriet Okatch, Timothy Joseph Sowicz, Helen Teng, Doreen Ramogola-Masire, Alison M Buttenheim
OBJECTIVES: To design and implement a case study on the cervical cancer screening program in Botswana to teach public and global health competencies to undergraduate nursing students. DESIGN AND SAMPLE: The case study was developed following a review of the literature on the epidemiology and health policies of cervical cancer in Botswana, and an interview with an obstetrician/gynecologist engaged in both clinical practice and research in Botswana. The case study has been implemented over seven semesters to students enrolled in the Nursing in the Community course at the University of Pennsylvania...
February 9, 2018: Public Health Nursing
https://www.readbyqxmd.com/read/29416813/the-prognostic-value-of-negative-lymph-node-count-for-patients-with-cervical-cancer-after-radical-surgery
#7
Hao Lu, Rong Guo, Haotian Yang, Haolu Wang, Xiaowen Liang, Zhiqian Hu, Xinxing Li
Negative lymph node (NLN) count has been recognized as a prognostic indicator in various cancers. However, the relationship between NLN count and the prognosis of cervical cancer is still unknown. In this study, 10, 500 cervical cancer patients after radical surgery were selected from Epidemiology and End Results Program (SEER) data. Clinicopathological characteristics were collected for analysis, including year of diagnosis, age, race, grade, primary site, FIGO stage and cause specific survival (CSS). Univariate and multivariate Cox proportional hazards model was used to assess risk factors for survival of patients...
January 5, 2018: Oncotarget
https://www.readbyqxmd.com/read/29388202/an-overview-of-cervical-cancer-epidemiology-and-prevention-in-scandinavia
#8
Kine Pedersen, Sara Fogelberg, Lise H Thamsborg, Mark Clements, Mari Nygård, Ivar S Kristiansen, Elsebeth Lynge, Pär Sparén, Jane J Kim, Emily A Burger
New technologies such as human papillomavirus (HPV) testing and vaccination necessitates comprehensive policy analyses to optimize cervical cancer prevention. To inform future Scandinavian-specific policy analyses, we aimed to provide an overview of cervical cancer epidemiology and existing prevention efforts in Denmark, Norway and Sweden. We compiled and summarized data on current prevention strategies, population demography, and epidemiology (e.g. age-specific HPV prevalence and cervical cancer incidence over time) for each Scandinavian country by reviewing published literature and official guidelines, performing registry-based analyses using primary data, and discussions with experts in each country...
February 1, 2018: Acta Obstetricia et Gynecologica Scandinavica
https://www.readbyqxmd.com/read/29385139/can-simple-trachelectomy-or-conization-show-comparable-survival-rate-compared-with-radical-trachelectomy-in-ia1-cervical-cancer-patients-with-lymphovascular-space-invasion-who-wish-to-save-fertility-a-systematic-review-and-guideline-recommendation
#9
Seung-Hyuk Shim, Myong Cheol Lim, Hyun Jung Kim, Maria Lee, Eun Ji Nam, Jung Yun Lee, Yoo-Young Lee, Kwang Beom Lee, Jeong Yeol Park, Yun Hwan Kim, Kyung Do Ki, Yong Jung Song, Hyun Hoon Chung, Sunghoon Kim, Jeong-Won Lee, Jae-Weon Kim, Duk-Soo Bae, Jong-Min Lee
OBJECTIVE: This study aims to analyze the published literatures on the effect of less radical fertility-preserving procedures, such as conization or simple trachelectomy, on oncological outcomes in IA1 cervical cancer patients with lymphovascular space invasion (LVSI) through a systematic-review. METHODS: The EMBASE and MEDLINE databases and Cochrane Library were searched for published studies reporting the oncological outcomes of conization/simple trachelectomy in these patients, through April 2017...
2018: PloS One
https://www.readbyqxmd.com/read/29375696/epidemiological-study-of-high-risk-human-papillomavirus-infection-in-subjects-with-abnormal-cytological-findings-in-cervical-cancer-screening
#10
Weizhi You, Shaocong Li, Ran Du, Jizeng Zheng, Aifang Shen
The present study aimed to determine the genotype and age distribution of high-risk human papillomavirus (HR-HPV) and evaluate HPV-DNA in subjects with abnormal cervical cytology results by using crowd-based cervical cancer screening cytology data. The Thinprep liquid-based cytologic test (TCT) was performed from January 2013 to January 2014 in the permanent residents of Liaocheng (China) aged 21-65 years who were married or had sexual intercourse. The number of screened women totaled 20,017, among whom 937 had abnormal results, 785 of which were recalled...
January 2018: Experimental and Therapeutic Medicine
https://www.readbyqxmd.com/read/29369158/the-growing-burden-of-non-communicable-disease-among-persons-living-with-hiv-in-zimbabwe
#11
Mikaela Smit, Jack Olney, Nathan P Ford, Marco Vitoria, Simon Gregson, Anna Vassall, Timothy B Hallett
OBJECTIVES: We aim to characterise the future noncommunicable disease (NCD) burden in Zimbabwe to identify future health system priorities. METHODS: We developed an individual-based multidisease model for Zimbabwe, simulating births, deaths, infection with HIV and progression, and key NCD (asthma, chronic kidney disease (CKD), depression, diabetes, hypertension, stroke, breast, cervical, colorectal, liver, oesophageal, prostate and all other cancers). The model was parameterised using national and regional surveillance and epidemiological data...
January 23, 2018: AIDS
https://www.readbyqxmd.com/read/29356877/cervical-cancer-induction-enhancement-potential-of-chlamydia-trachomatis-a-systematic-review
#12
REVIEW
Safae Karim, Tiatou Souho, Mohamed Benlemlih, Bahia Bennani
Human papillomavirus (HPV) persistent infection is the necessary but not sufficient cause of cervical cancer. Other co-factors are required to induce cell transformation that will evolve to malignant cervical cancer. These co-factors include physical elements, other sexually transmitted infections, and immune response. Chlamydia trachomatis the most common bacterial sexually transmitted infection is often asymptomatic but causes various syndromes such as cervicitis, endometritis, pelvic inflammatory disease, and infertility...
January 22, 2018: Current Microbiology
https://www.readbyqxmd.com/read/29356609/epidemiologic-evidence-that-excess-body-weight-increases-risk-of-cervical-cancer-by-decreased-detection-of-precancer
#13
Megan A Clarke, Barbara Fetterman, Li C Cheung, Nicolas Wentzensen, Julia C Gage, Hormuzd A Katki, Brian Befano, Maria Demarco, John Schussler, Walter K Kinney, Tina R Raine-Bennett, Thomas S Lorey, Nancy E Poitras, Philip E Castle, Mark Schiffman
Purpose Obesity has been inconsistently linked to increased cervical cancer incidence and mortality; however, the effect of obesity on cervical screening has not been explored. We investigated the hypothesis that increased body mass might decrease detection of cervical precancer and increase risk of cervical cancer even in women undergoing state-of-the-art screening. Methods We conducted a retrospective cohort study of 944,227 women age 30 to 64 years who underwent cytology and human papillomavirus DNA testing (ie, cotesting) at Kaiser Permanente Northern California (January 2003 to December 2015)...
January 22, 2018: Journal of Clinical Oncology: Official Journal of the American Society of Clinical Oncology
https://www.readbyqxmd.com/read/29331480/human-papillomavirus-hpv-18-genetic-variants-and-cervical-cancer-risk-in-taizhou-area-china
#14
Hui-Hui Xu, Ling-Zhi Zheng, Ai-Fen Lin, Shan-Shan Dong, Ze-Ying Chai, Wei-Hua Yan
Human papillomavirus (HPV) type 18 is predominantly associated with the development of cervical adenocarcinomas, whereas data on HPV18 genetic variability in China are limited. HPV18 genetic variants were formed phylogenetic tree, including lineages A, B, and C. We aimed to evaluate the diversity of HPV18 genetic variants by sequencing the entire E6, E7 and L1 genes. Between 2012 and 2015, a total of 138 (0.8%, 138/17669) women with single HPV18 infection were selected in this study. Finally, we observed 122 HPV18 isolates of the complete E6-E7-L1 sequences, and obtained 36 distinct variation patterns which the accession GenBank numbers as KY457805-KY457840...
January 10, 2018: Gene
https://www.readbyqxmd.com/read/29329337/mitochondrial-dna-ancestry-hpv-infection-and-the-risk-of-cervical-cancer-in-a-multiethnic-population-of-northeastern-argentina
#15
Ines Badano, Daiana J Sanabria, Maria E Totaro, Samara Rubinstein, Juan A Gili, Domingo J Liotta, Maria A Picconi, Rodolfo H Campos, Theodore G Schurr
BACKGROUND: Misiones Province in northeastern Argentina is considered to be a region with a high prevalence of HPV infection and a high mortality rate due to cervical cancer. The reasons for this epidemiological trend are not completely understood. To gain insight into this problem, we explored the relationship between mitochondrial DNA (mtDNA) ancestry, HPV infection, and development of cervical lesions/cancer in women from the city of Posadas in Misiones Province. METHODS: Two hundred and sixty-one women, including 92 cases of patients diagnosed with cervical lesions and 169 controls, were analyzed...
2018: PloS One
https://www.readbyqxmd.com/read/29322686/human-papilloma-virus-an-etiological-and-prognostic-factor-for-oral-cancer
#16
REVIEW
Gloria I Lafaurie, Sandra J Perdomo, María R Buenahora, Sandra Amaya, David Díaz-Báez
The increasing prevalence of human papilloma virus (HPV)-positive oral tumors can be considered an epidemic. Although the incidence of HPV cervical cancer is decreasing, the incidence of oral cavity and oropharyngeal cancers associated with HPV is increasing. The presence of certain HPV genotypes could be a predictor of future oral cancer lesions, although lesions associated with HPV could be less aggressive and exhibit a higher survival rate. In the present study, we review the most important biologic, clinic, epidemiologic, and prognostic factors associated with HPV infection and oral cancer...
January 10, 2018: Journal of Investigative and Clinical Dentistry
https://www.readbyqxmd.com/read/29286611/descriptive-epidemiology-of-cancers-in-togo-from-2009-to-2016
#17
Tchin Darre, Tchilabalo M Kpatcha, Aklesso Bagny, Nidain Maneh, Faré Gnandi-Piou, Boyodi Tchangai, Sassil Daré, Solange Adani-Ifé, Atchi Walla, Koffi Amégbor, Gado Napo-Koura
Background: Cancer is a global public health problem. According to World Report on Cancer in 2000, developing countries are becoming increasingly affected. Methods: This retrospective and descriptive 8-year study of all histological confirmed cancers was conducted using data from the anatomical pathology laboratory registry of Togo’s only laboratory. The parameters were frequency, site and histological type as well as age and gender. Results: We found 1,738 cancers in patients aged from 4 months to 109 years (mean, 50...
December 29, 2017: Asian Pacific Journal of Cancer Prevention: APJCP
https://www.readbyqxmd.com/read/29275831/-advances-in-the-management-of-cervical-lymphadenopathies-of-unknown-primary-advances-in-diagnostic-imaging-and-surgical-modalities-and-new-international-staging-system
#18
REVIEW
Idriss Troussier, Guillaume Klausner, Sylvain Morinière, Eivind Blais, Jean-Christophe Faivre, Ambroise Champion, Lionnel Geoffrois, Carole Pflumio, Emmanuel Babin, Philippe Maingon, Juliette Thariat
INTRODUCTION: Cervical lymphadenopathies of unknown primary represent 3 % of head and neck cancers. Their diagnostic work up has largely changed in recent years. This review provides an update on diagnostic developments and their potential therapeutic impact. MATERIALS AND METHODS: This is a systematic review of the literature. RESULTS: In recent years, changes in epidemiology-based prognostic factors such as human papilloma virus (HPV) cancers, advances in imaging and minimally invasive surgery have been integrated in the management of cervical lymphadenopathies of unknown primary...
December 21, 2017: Bulletin du Cancer
https://www.readbyqxmd.com/read/29244993/cervical-cancer-in-the-greater-accra-and-ashanti-regions-of-ghana
#19
Yvonne Nartey, Philip C Hill, Kwabena Amo-Antwi, Kofi M Nyarko, Joel Yarney, Brian Cox
Purpose Cervical cancer is a common cancer among women worldwide. An estimated 528,000 new cases and 266,000 deaths occurred in 2012. More than 85% of invasive cervical cancer cases occur in low- and middle-income countries. Cervical cancer ranks as the most common cancer among women in Ghana. We conducted a retrospective study to assess the descriptive epidemiology of cervical cancer in Ghana. We describe cervical cancer incidence and mortality rates for the regions served by two large hospitals in Ghana. Patients and Methods Information for women diagnosed with invasive cervical cancer between 2010 and 2013 was collected from the Komfo Anokye and Korle Bu Teaching Hospitals through review of medical, computer, and pathology records at the oncology units and the obstetrics and gynecology departments...
December 2017: Journal of Global Oncology
https://www.readbyqxmd.com/read/29234950/the-evolution-of-endometrial-carcinoma-classification-through-application-of-immunohistochemistry-and-molecular-diagnostics-past-present-and-future
#20
REVIEW
Emily A Goebel, August Vidal, Xavier Matias-Guiu, C Blake Gilks
Uterine cancer was first subclassified based on anatomic site, separating those tumours arising from the endometrium from cervical cancers. There was then further subclassification of endometrial cancers based on cell type, and this correlated with the Type I and Type II categories identified through the epidemiological studies of Bokhman, with endometrioid carcinoma corresponding (approximately) to Type I and serous carcinoma to Type II. These histotypes are not clearly separable in practice, however, with considerable interobserver variability in histotype diagnosis, especially for high-grade tumours...
December 12, 2017: Virchows Archiv: An International Journal of Pathology
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