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https://www.readbyqxmd.com/read/29153414/association-of-interleukin-1-receptor-like-1-gene-polymorphisms-with-eosinophilic-phenotype-in-japanese-adults-with-asthma
#1
Hideki Inoue, Isao Ito, Akio Niimi, Hisako Matsumoto, Tsuyoshi Oguma, Tomoko Tajiri, Toshiyuki Iwata, Tadao Nagasaki, Yoshihiro Kanemitsu, Toshitaka Morishima, Tomomitsu Hirota, Mayumi Tamari, Sally E Wenzel, Michiaki Mishima
BACKGROUND: IL1RL1 (ST2) is involved in Th2 inflammation including eosinophil activation. Single nucleotide polymorphisms (SNPs) of the IL1RL1 gene are associated with asthma development and increased peripheral blood eosinophil counts. However, the association between IL1RL1 SNPs and eosinophilic phenotype among adults with asthma remains unexplored. METHODS: In a primary cohort of 110 adult Japanese patients with stable asthma, we examined the associations between IL1RL1 SNPs and clinical measurements including forced expiratory volume (FEV1), airway reversibility of FEV1, exhaled nitric oxide (FeNO), serum soluble-ST2 (sST2) levels, peripheral blood eosinophil differentials and serum total IgE level...
November 2017: Respiratory Investigation
https://www.readbyqxmd.com/read/29133224/feno-and-exercise-testing-in-children-at-risk-of-asthma
#2
Ann-Marie Malby Schoos, Christina Figgé Christiansen, Jakob Stokholm, Klaus Bønnelykke, Hans Bisgaard, Bo Lund Chawes
BACKGROUND: Exercise testing is the gold standard for diagnosing exercise-induced bronchoconstriction in children, but requires considerable cooperation and medical resources. Therefore, fraction of exhaled nitric oxide (FeNO) has been proposed as a tool to predict the need for exercise testing. OBJECTIVE: The objective of this study was to investigate the relationship between FeNO, exercise test results, and a history of respiratory symptoms during exercise in children at risk of asthma...
November 10, 2017: Journal of Allergy and Clinical Immunology in Practice
https://www.readbyqxmd.com/read/29128336/the-value-of-fractional-exhaled-nitric-oxide-and-forced-mid-expiratory-flow-as-predictive-markers-of-bronchial-hyperresponsiveness-in-adults-with-chronic-cough
#3
Wuping Bao, Xue Zhang, Chengjian Lv, Luhong Bao, Junfeng Yin, Zhixuan Huang, Bing Wang, Xin Zhou, Min Zhang
BACKGROUND: Bronchial provocation tests are standard for diagnosing the etiology of chronic cough, but they are time consuming and can induce severe bronchospasm. A safer and faster clinical examination to predict bronchial hyperresponsiveness (BHR) is needed. OBJECTIVE: The objective of this study was to investigate whether small-airway function tests can predict BHR in adult patients with chronic cough. METHODS: A retrospective, cross-sectional study of diagnoses made using spirometry and bronchial provocation test results was performed in 290 patients with chronic nonproductive cough...
November 8, 2017: Journal of Allergy and Clinical Immunology in Practice
https://www.readbyqxmd.com/read/29110960/the-clinical-role-of-fractional-exhaled-nitric-oxide-in-asthma-control
#4
Suguru Sato, Junpei Saito, Atsuro Fukuhara, Manabu Uematsu, Yasuhito Suzuki, Ryuichi Togawa, Yuki Sato, Takefumi Nikaido, Xintao Wang, Yoshinori Tanino, Mitsuru Munakata
BACKGROUND: The potential role and characteristics of fractional exhaled nitric oxide (FeNO) remain unclear in the treatment of asthma. OBJECTIVE: To explore the clinical role of FeNO in asthmatic treatment. METHODS: We evaluated whether the mean or change of FeNO levels in the treatment period is associated with other conventional control parameters and predicted some clinical outcomes of asthma. We retrospectively analyzed the mean and percentage change of FeNO levels in the first 5 measurements at our hospital...
October 27, 2017: Annals of Allergy, Asthma & Immunology
https://www.readbyqxmd.com/read/29094021/the-asthma-and-chronic-obstructive-pulmonary-disease-overlap-syndrome-in-tertiary-care-setting-thailand
#5
Theerasuk Kawamatawong, Sanruethai Charoenniwassakul, Ticha Rerkpattanapipat
Background: Asthma and chronic obstructive pulmonary disease (COPD) overlap syndrome (ACOS) is an increasingly recognized clinical entity. ACOS significantly impacts on patient outcome compared to isolated asthma or COPD. However, ACOS definition and diagnosis criteria have not been well standardized. ACOS prevalence and clinical features in Thailand has never been studied. Objective: To investigate the prevalence and clinical features of ACOS compared to isolated asthma or COPD among patients with clinician-diagnosis of obstructive airway diseases...
October 2017: Asia Pacific Allergy
https://www.readbyqxmd.com/read/29072125/the-effects-of-ramadan-intermittent-fasting-rif-on-spirometric-data-of-stable-copd-patients-a-pilot-study
#6
Hajer Zouari, Imed Latiri, Mohamed Mahjoub, Mohamed Boussarsar, Mohamed Benzarti, Ahmed Abdelghani, Helmi Ben Saad
No previous study has raised the effects of RIF on lung function data of chronic obstructive pulmonary disease (COPD) patients. The objective of the present study was to assess the effects of RIF on spirometric data measured in male patients with a stable COPD. Sixteen patients with stable COPD (mean ± SD of age: 64 ± 7 years) who fasted during Ramadan volunteered to the study. Three sessions (Before-R, End-R, and After-R) were selected for spirometry tests that were consistently performed 2.5-4.5 hr before fasting break...
October 1, 2017: American Journal of Men's Health
https://www.readbyqxmd.com/read/29046188/association-of-imbalance-of-effector-t-cells-and-regulatory-cells-with-the-severity-of-asthma-and-allergic-rhinitis-in-children
#7
Fei Huang, Jia-Ning Yin, Hong-Bo Wang, Shou-Yue Liu, Ya-Nan Li
PURPOSE: This study investigated the frequency and absolute numbers of different subsets of peripheral blood cells, including CD4+ T cells and CD19+ interleukin (IL) 10+ B regulatory cells (Breg) and their potential association with clinical laboratory measurements in children diagnosed with simple asthma or asthma plus allergic rhinitis (AR). METHOD: The frequency and numbers of peripheral blood CD4+ interferon (IFN) gamma+ T-helper (Th) type 1, CD4+ IL-4+ Th2, CD4+ IL-17A+ Th17, CD4+CD25+ Forkhead Box P3+ regulatory T cells (Treg) and CD19+ IL-10+ Bregs in 22 children with asthma, 17 children with asthma and AR, and 25 healthy controls were determined by flow cytometry...
November 1, 2017: Allergy and Asthma Proceedings:
https://www.readbyqxmd.com/read/29042800/postpartum-airway-responsiveness-and-exacerbation-of-asthma-during-pregnancy-a-pilot-study
#8
Zarqa Ali, Lisbeth Nilas, Charlotte Suppli Ulrik
BACKGROUND: Airway responsiveness and inflammation are associated with the clinical manifestations of asthma and the response to pharmacological therapy. OBJECTIVE: To investigate if airway responsiveness and inflammatory characteristics are related to asthma exacerbations during pregnancy. MATERIALS AND METHODS: In women with asthma who were prescribed controller medication and monitored closely during pregnancy, the risk of exacerbations was analyzed in relation to postpartum measures of fractional exhaled nitric oxide (FENO), skin prick test reactivity, static and dynamic lung volumes, diffusing capacity for carbon monoxide, bronchial responsiveness to inhaled mannitol, and inflammatory characteristics in induced sputum...
2017: Journal of Asthma and Allergy
https://www.readbyqxmd.com/read/29034296/diagnosis-of-asthma-in-symptomatic-children-based-on-measures-of-lung-function-an-analysis-of-data-from-a-population-based-birth-cohort-study
#9
Clare Murray, Philip Foden, Lesley Lowe, Hannah Durrington, Adnan Custovic, Angela Simpson
BACKGROUND: Concerns have been expressed about asthma overdiagnosis. The UK National Institute of Health and Care Excellence (NICE) proposed a new diagnostic algorithm applying four lung function measures sequentially (ratio of forced expiratory volume in 1 s [FEV1] to forced vital capacity [FVC] <70%, bronchodilator reversibility ≥12%, fractional exhaled nitric oxide [FeNO] ≥35 parts per billion, and peak expiratory flow variability >20%). We aimed to assess the diagnostic value of three of the tests individually, and then test the proposed algorithm in symptomatic children...
October 2017: Lancet Child Adolesc Health
https://www.readbyqxmd.com/read/28993393/recurrent-wheeze-and-its-relationship-with-lung-function-and-airway-inflammation-in-preschool-children-a-cross-sectional-study-in-south-korea
#10
Ji Eun Soh, Kyung-Moon Kim, Ji-Won Kwon, Hyung Young Kim, Ju-Hee Seo, Hyo-Bin Kim, So-Yeon Lee, Gwang-Cheon Jang, Dae-Jin Song, Woo Kyung Kim, Young-Ho Jung, Soo-Jong Hong, Jung Yeon Shim
BACKGROUND: Relationship between recurrent wheeze and airway function and inflammation in preschool children is not fully known. OBJECTIVE: To investigate the relationship between recurrent wheeze and airway inflammation, lung function, airway hyper-reactivity (AHR) and atopy in preschool children. DESIGN: Observational study, comparing forced expiratory volume in 1 s (FEV1), forced vital capacity (FVC) and mid-forced expiratory flow (FEF25%-75%), dose-response slope (DRS), exhaled nitric oxide (eNO) and atopic sensitisation between children with recurrent wheeze and those without...
October 8, 2017: BMJ Open
https://www.readbyqxmd.com/read/28987568/short-term-effects-of-various-ozone-metrics-on-cardiopulmonary-function-in-chronic-obstructive-pulmonary-disease-patients-results-from-a-panel-study-in-beijing-china
#11
Hongyu Li, Shaowei Wu, Lu Pan, Junhui Xu, Jiao Shan, Xuan Yang, Wei Dong, Furong Deng, Yahong Chen, Masayuki Shima, Xinbiao Guo
BACKGROUND: Short-term exposure to ambient air pollution has been associated with lower pulmonary function and higher blood pressure (BP). However, controversy remains regarding the relationship between ambient multiple daily ozone (O3) metrics and cardiopulmonary health outcomes, especially in the developing countries. OBJECTIVES: To investigate and compare the short-term effects of various O3 metrics on pulmonary function, fractional exhaled nitric oxide (FeNO) and BP in a panel study of COPD patients...
October 5, 2017: Environmental Pollution
https://www.readbyqxmd.com/read/28984368/autogenic-drainage-for-airway-clearance-in-cystic-fibrosis
#12
REVIEW
Pamela McCormack, Paul Burnham, Kevin W Southern
BACKGROUND: Autogenic drainage is an airway clearance technique that was developed by Jean Chevaillier in 1967. The technique is characterised by breathing control using expiratory airflow to mobilise secretions from smaller to larger airways. Secretions are cleared independently by adjusting the depth and speed of respiration in a sequence of controlled breathing techniques during exhalation. The technique requires training, concentration and effort from the individual. It is important to systematically review the evidence demonstrating that autogenic drainage is an effective intervention for people with cystic fibrosis...
October 6, 2017: Cochrane Database of Systematic Reviews
https://www.readbyqxmd.com/read/28982775/a-virtual-asthma-clinic-for-children-fewer-routine-outpatient-visits-same-asthma-control
#13
Lara S van den Wijngaart, Jolt Roukema, Annemie L M Boehmer, Marianne L Brouwer, Cindy A C Hugen, Laetitia E M Niers, Arwen J Sprij, Eleonora R V M Rikkers-Mutsaerts, Bart L Rottier, A Rogier T Donders, Chris M Verhaak, Mariëlle W Pijnenburg, Peter J F M Merkus
eHealth is an appealing medium to improve healthcare and its value (in addition to standard care) has been assessed in previous studies. We aimed to assess whether an eHealth intervention could improve asthma control while reducing 50% of routine outpatient visits.In a multicentre, randomised controlled trial with a 16-month follow-up, asthmatic children (6-16 years) treated in eight Dutch hospitals were randomised to usual care (4-monthly outpatient visits) and online care using a virtual asthma clinic (VAC) (8-monthly outpatient visits with monthly web-based monitoring)...
October 2017: European Respiratory Journal: Official Journal of the European Society for Clinical Respiratory Physiology
https://www.readbyqxmd.com/read/28979110/differences-in-systemic-inflammation-between-cigarette-and-biomass-smoke-induced-copd
#14
Rafael Golpe, Irene Martín-Robles, Pilar Sanjuán-López, Luis Pérez-de-Llano, Carlos González-Juanatey, José L López-Campos, Elena Arellano-Orden
BACKGROUND AND OBJECTIVE: It is known that biomarkers of systemic inflammation are raised in COPD caused by tobacco (T-COPD) compared with healthy controls, but there is less information on the inflammatory status of subjects with COPD caused by biomass smoke (B-COPD). In addition, the possible (if any) differences in inflammation between both types of the disease are still not well known. The aim of this study was to assess the inflammatory profile in B-COPD and T-COPD. METHODS: A total of 20 subjects (15 men and five women) with T-COPD were matched one to one for sex, age and forced expiratory volume in 1 s (FEV1) to 20 B-COPD patients...
2017: International Journal of Chronic Obstructive Pulmonary Disease
https://www.readbyqxmd.com/read/28959121/inhaled-steroids-and-active-smoking-drive-chronic-obstructive-pulmonary-disease-symptoms-and-biomarkers-to-a-greater-degree-than-airflow-limitation
#15
Philip E Silkoff, Dave Singh, J Mark FitzGerald, Andreas Eich, Andrea Ludwig-Sengpiel, Geoffrey C Chupp, Vibeke Backer, Celeste Porsbjerg, Pierre-Olivier Girodet, Mark T Dransfield, Frederic Baribaud, Vedrana S Susulic, Matthew J Loza
RATIONALE: Chronic obstructive pulmonary disease (COPD) is a heterogeneous disease, and development of novel therapeutics requires an understanding of pathophysiologic phenotypes. OBJECTIVES: The purpose of the Airways Disease Endotyping for Personalized Therapeutics (ADEPT) study was to correlate clinical features and biomarkers with molecular characteristics in a well-profiled COPD cohort. METHODS: A total of 67 COPD subjects (forced expiratory volume in the first second of expiration [FEV1]: 45%-80% predicted) and 63 healthy smoking and nonsmoking controls underwent multiple assessments including patient questionnaires, lung function, and clinical biomarkers including fractional exhaled nitric oxide (FENO), induced sputum, and blood...
2017: Biomarker Insights
https://www.readbyqxmd.com/read/28942008/transport-of-ellipsoid-fibers-in-oscillatory-shear-flows-implications-for-aerosol-deposition-in-deep-airways
#16
Lihi Shachar-Berman, Yan Ostrovski, Alessandro De Rosis, Stavros Kassinos, Josué Sznitman
It is widely acknowledged that inhaled fibers, e.g. air pollutants and anthropogenic particulate matter, hold the ability to deposit deep into the lungs reaching the distal pulmonary acinar airways as a result of their aerodynamic properties; these particles tend to align with the flow and thus stay longer airborne relative to their spherical counterpart, due to higher drag forces that resist sedimentation. Together with a high surface-to-volume ratio, such characteristics may render non-spherical particles, and fibers in particular, potentially attractive airborne carriers for drug delivery...
September 20, 2017: European Journal of Pharmaceutical Sciences
https://www.readbyqxmd.com/read/28940836/small-airway-involvement-in-the-late-allergic-response-in-asthma
#17
Henning Stenberg, Zuzana Diamant, Jaro Ankerst, Leif Bjermer, Ellen Tufvesson
BACKGROUND: Allergy and asthma are closely linked. Inhalation of allergen induces an early allergic response (EAR) within the airways of allergic asthmatic subjects, which is followed by a late allergic response (LAR) in approximately 50% of the subjects. The LAR is defined as a drop in forced expiratory volume in 1 s (FEV1 ) from baseline usually occurring 4-8 h after exposure, and is believed to affect small airways. However, FEV1 is insensitive to changes in small airway physiology...
September 21, 2017: Clinical and Experimental Allergy: Journal of the British Society for Allergy and Clinical Immunology
https://www.readbyqxmd.com/read/28929816/which-inhaled-corticosteroid-and-long-acting-%C3%AE-agonist-combination-is-better-in-patients-with-moderate-to-severe-asthma-a-dry-powder-inhaler-or-a-pressurized-metered-dose-inhaler
#18
Masato Muraki, Kyuya Gose, Soichiro Hanada, Hirochiyo Sawaguchi, Yuji Tohda
Two main types of devices are used to facilitate the administration of inhaled corticosteroid (ICS) and long-acting β-agonist (LABA) in combination, dry powder inhalers (DPIs) and pressurized metered-dose inhalers (pMDIs). There are few reports comparing the effects of the two devices, and it is unknown which should be recommended for asthma patients with given sets of characteristics. In the current study, the beneficial effects and side effects associated with DPIs and pMDIs were compared, and the question of which device should be recommended for asthma patients was investigated...
November 2017: Drug Delivery
https://www.readbyqxmd.com/read/28917963/an-efficient-computational-fluid-particle-dynamics-method-to-predict-deposition-in-a-simplified-approximation-of-the-deep-lung
#19
P G Koullapis, P Hofemeier, J Sznitman, S C Kassinos
High-fidelity simulations of the complete airway tree are still largely beyond current computational capabilities. Towards large-scale simulations of the human lung, the current study introduces a numerical methodology to predict particle deposition in a simplified approximation of the deep lung during a full breathing cycle. The geometrical model employed consists of an idealised bronchial tree that represents generations 10 to 19 of the conducting zone and an heterogeneous acinar model created using a space-filling algorithm...
September 13, 2017: European Journal of Pharmaceutical Sciences
https://www.readbyqxmd.com/read/28874982/measurement-of-milwaukee-brace-pad-pressure-in-adolescent-round-back-deformity-treatment
#20
Taher Babaee, Mojtaba Kamyab, Amir Ahmadi, Mohammad Ali Sanjari, Mohammad Saleh Ganjavian
STUDY DESIGN: In this prospective study, we measured the pad pressures of the Milwaukee brace in adolescent hyperkyphosis treatment. PURPOSE: We evaluated the skin-brace interface forces exerted by the main pads of the Milwaukee brace. OVERVIEW OF LITERATURE: A fundamental factor associated with brace effectiveness in spinal deformity is pad force adjustment. However, few studies have evaluated the in-brace force magnitude and its effect on curve correction...
August 2017: Asian Spine Journal
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