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https://www.readbyqxmd.com/read/28810625/inhaled-corticosteroids-improve-lung-function-airway-hyper-responsiveness-and-airway-inflammation-but-not-symptom-control-in-patients-with-mild-intermittent-asthma-a-meta-analysis
#1
Wei Du, Ling Zhou, Yingmeng Ni, Yuanyuan Yu, Fang Wu, Guochao Shi
It remains controversial whether inhaled corticosteroid (ICS) should be used in patients with intermittent asthma. The present study aimed to assess the effect of ICS compared with placebo or other therapies in patients with intermittent asthma. Medline, Embase and CNKI databases were searched up to June 2016 and a meta-analysis was conducted. The findings demonstrated that in adult patients, when compared with placebo, ICS increased forced expiratory volume in 1 sec FEV1 [standardized mean difference (SMD), 0...
August 2017: Experimental and Therapeutic Medicine
https://www.readbyqxmd.com/read/28803201/influence-of-architectural-style-on-indoor-radon-concentration-in-a-radon-prone-area-a-case-study
#2
A Baeza, J García-Paniagua, J Guillén, B Montalbán
Indoor radon is a major health concern as it is a known carcinogenic. Nowadays there is a trend towards a greater energy conservation in buildings, which is reflected in an increasing number of regulations. But, can this trend increase the indoor radon concentration? In this paper, we selected a radon prone area in Spain and focused on single-family dwellings constructed in a variety of architectural styles. These styles ranged from 1729 up to 2014, with varying construction techniques (from local resources to almost universally standard building materials) and regulations in force (from none to the Spanish regulation in force)...
August 10, 2017: Science of the Total Environment
https://www.readbyqxmd.com/read/28791362/correlation-analysis-of-surfactant-protein-a-and-surfactant-protein-d-with-lung-function-in-exhaled-breath-condensate-from-lung-cancer-patients-with-and-without-copd
#3
Xuefeng Lin, Zhenlin Wu, Yichu Fan, Mingyou Chi, Xiaodong Wang, Xun Zhang, Daqiang Sun
Pulmonary surfactant protein A (SP‑A) and pulmonary surfactant protein D (SP‑D) are associated with the pathogenesis of chronic obstructive pulmonary disease (COPD). The aim of the present study was to determine the correlation between SP‑A, SP‑D and lung function in patients with COPD. A total of 60 patients with lung cancer undergoing unilateral lobectomy were selected and divided into three groups, including a non‑COPD group (n=20), a COPD treatment group (n=20) and a COPD control group (n=20)...
August 7, 2017: Molecular Medicine Reports
https://www.readbyqxmd.com/read/28751866/ventilatory-efficiency-in-children-and-adolescents-born-extremely-preterm
#4
Julie Hestnes, Hedda Hoel, Ole J Risa, Hanna O Romstøl, Ola Røksund, Bente Frisk, Einar Thorsen, Thomas Halvorsen, Hege H Clemm
Purpose: Children and adolescents born extremely preterm (EP) have lower dynamic lung volumes and gas transfer capacity than subjects born at term. Most studies also report lower aerobic capacity. We hypothesized that ventilatory efficiency was poorer and that breathing patterns differed in EP-born compared to term-born individuals. Methods: Two area-based cohorts of participants born with gestational age ≤28 weeks or birth weight ≤1000 g in 1982-85 (n = 46) and 1991-92 (n = 35) were compared with individually matched controls born at term...
2017: Frontiers in Physiology
https://www.readbyqxmd.com/read/28749779/weekly-personal-ozone-exposure-and-respiratory-health-in-a-panel-of-greek-schoolchildren
#5
Anna Karakatsani, Evangelia Samoli, Sophia Rodopoulou, Konstantina Dimakopoulou, Despina Papakosta, Dionisios Spyratos, Georgios Grivas, Sofia Tasi, Nikolaos Angelis, Athanasios Thirios, Anastasios Tsiotsios, Klea Katsouyanni
BACKGROUND: The association of ozone exposure with respiratory outcomes has been investigated in epidemiologic studies mainly including asthmatic children. The findings reported had methodological gaps and inconsistencies. OBJECTIVES: We aimed to investigate effects of personal ozone exposure on various respiratory outcomes in school-age children generally representative of the population during their normal activities. METHODS: We conducted a panel study in a representative sample of school-age children in the two major cities of Greece, Athens and Thessaloniki...
July 21, 2017: Environmental Health Perspectives
https://www.readbyqxmd.com/read/28748646/small-airway-dysfunction-in-chronic-hypersensitivity-pneumonitis
#6
Selene Guerrero Zúñiga, Julia Sánchez Hernández, Heidegger Mateos Toledo, Mayra Mejía Ávila, Laura Gochicoa-Rangel, José Luis Miguel Reyes, Moisés Selman, Luis Torre-Bouscoulet
BACKGROUND AND OBJECTIVE: Lung biopsies from patients with hypersensitivity pneumonitis (HP) have demonstrated small airway (SA) involvement, but there is no information concerning SA function in HP, and it is unknown whether pharmacological treatment could modify its function. SA function in patients with chronic HP using ultrasonic pneumography (UPG) and impulse oscillometry (IOS) was explored. We also compared initial results with those obtained after 4 weeks of standardized treatment with azathioprine and prednisone...
July 26, 2017: Respirology: Official Journal of the Asian Pacific Society of Respirology
https://www.readbyqxmd.com/read/28713086/intensifying-approach-to-the-therapy-of-patients-with-constellation-of-the-diseases-chronic-obstructive-pulmonary-disease-and-osteoarthritis
#7
Vyacheslav N Zhdan, Maksim М Potyazhenko, Galina S Khaymenova, Nadezhda N Lyulka, Tatyana V Dubrovinskaya, Igor V Ivanitsky
INTRODUCTION: Chronic obstructive pulmonary disease (COPD) is one of 21st century. About 210 million people all over the world are suffering with COPD, and annually 3 million people die of it. Under the influence of different factors, such as smoking, air prolusion, evaporation of chemicals, poisoning effect of chemical firings, inflammation processes take place in lungs, and if it is prolonged and take place simultaneously with morphological changes in the lungs, it it provide the de4velopment of the systemic inflammation process...
2017: Wiadomości Lekarskie: Organ Polskiego Towarzystwa Lekarskiego
https://www.readbyqxmd.com/read/28704185/phenotypes-determined-by-cluster-analysis-in-moderate-to-severe-bronchial-asthma
#8
Vania M Youroukova, Denitsa G Dimitrova, Anna D Valerieva, Spaska S Lesichkova, Tsvetelina V Velikova, Ekaterina I Ivanova-Todorova, Kalina D Tumangelova-Yuzeir
BACKGROUND: Bronchial asthma is a heterogeneous disease that includes various subtypes. They may share similar clinical characteristics, but probably have different pathological mechanisms. AIM: To identify phenotypes using cluster analysis in moderate to severe bronchial asthma and to compare differences in clinical, physiological, immunological and inflammatory data between the clusters. PATIENTS AND METHODS: Forty adult patients with moderate to severe bronchial asthma out of exacerbation were included...
June 1, 2017: Folia Medica
https://www.readbyqxmd.com/read/28696913/linking-physiological-parameters-to-perturbations-in-the-human-exposome-environmental-exposures-modify-blood-pressure-and-lung-function-via-inflammatory-cytokine-pathway
#9
Matthew A Stiegel, Joachim D Pleil, Jon R Sobus, Tina Stevens, Michael C Madden
Human biomonitoring is an indispensable tool for evaluating the systemic effects derived from external stressors including environmental pollutants, chemicals from consumer products, and pharmaceuticals. The aim of this study was to explore consequences of environmental exposures to diesel exhaust (DE) and ozone (O3) and ultimately to interpret these parameters from the perspective of in vitro to in vivo extrapolation. In particular, the objective was to use cytokine expression at the cellular level as a biomarker for physiological systemic responses such as blood pressure and lung function at the systemic level...
July 11, 2017: Journal of Toxicology and Environmental Health. Part A
https://www.readbyqxmd.com/read/28692015/the-association-between-particulate-matter-air-pollution-and-respiratory-health-in-elderly-with-type-2-diabetes-mellitus
#10
Yanhui Hao, Jing Zhao, Kan Wang, Nannan Feng, Pin Sun, Renjie Chen, Bin Han, Zhipeng Bai, Yiliang Zhu, Ying Gao, Zhao-Lin Xia
OBJECTIVE: We investigated the association between respiratory health and particulate matter (PM) air pollution in elderly type 2 diabetes mellitus (T2DM) pre-, during, and post-the Chinese Lunar New Year (CLNY) holiday in Shanghai, China. METHODS: We conducted repeated measurements of lung function and inflammation biomarker in a cohort consisted of 60 participants with T2DM. RESULTS: Decreased PM2.5 exposure had an effect on respiratory health by increasing in forced expiratory flow in 1 second (FEV1) and forced vital capacity (FVC)...
July 6, 2017: Journal of Occupational and Environmental Medicine
https://www.readbyqxmd.com/read/28676036/tobacco-use-among-kyrgyzstan-medical-students-an-11-year-follow-up-cross-sectional-study
#11
Nurlan Brimkulov, Denis Vinnikov, Zhamilia Dzhilkiadarova, Aigerim Aralbaeva
BACKGROUND: Medical students are the first line active force to combat tobacco epidemic, but they may suffer from high smoking prevalence and wrong attitude themselves. The aim of the study was to assess the effect of current curriculum on smoking behavior of medical students in Kyrgyzstan. METHODS: 20% random sample of all 6 years of the School of Medicine in Kyrgyz State Medical Academy were interviewed in spring 2016. The questionnaire included sections on tobacco products consumption and knowledge and attitude to counseling...
July 4, 2017: BMC Public Health
https://www.readbyqxmd.com/read/28663317/a-sputum-gene-expression-signature-predicts-oral-corticosteroid-response%C3%A2-in%C3%A2-asthma
#12
Bronwyn S Berthon, Peter G Gibson, Lisa G Wood, Lesley K MacDonald-Wicks, Katherine J Baines
Biomarkers that predict responses to oral corticosteroids (OCS) facilitate patient selection for asthma treatment. We hypothesised that asthma patients would respond differently to OCS therapy, with biomarkers and inflammometry predicting response.Adults with stable asthma underwent a randomised controlled cross-over trial of 50 mg prednisolone daily for 10 days (n=55). A six-gene expression biomarker signature (CLC, CPA3, DNASE1L3, IL1B, ALPL and CXCR2) in induced sputum, and eosinophils in blood and sputum were assessed and predictors of response were investigated (changes in forced expiratory volume in 1 s (ΔFEV1), six-item Asthma Control Questionnaire score (ΔACQ6) or exhaled nitric oxide fraction (ΔFeNO))...
June 2017: European Respiratory Journal: Official Journal of the European Society for Clinical Respiratory Physiology
https://www.readbyqxmd.com/read/28660856/innovative-exhaled-breath-analysis-with-old-breathing-manoeuvres-is-there-a-problem-or-an-advantage
#13
Marieann Högman
As the field of exhaled breath research is expanding, the question that arises is can the old usual method of spirometry be used in all cases? The answer is yes for some analysation methods and definitely not for others: it all depends on the result you are looking for. Exhaled breath condensate collection can be accomplished with silent tidal breathing, but not in the analysation of the amount of exhaled particles, as they become very low during tidal breathing. There are gases that are exhalation flow dependent, e...
June 29, 2017: Journal of Breath Research
https://www.readbyqxmd.com/read/28656903/association-of-extended-nitric-oxide-parameters-with-bronchial-hyperresponsiveness-and-bronchodilator-response-in-children-with-asthma
#14
Yoon Hee Kim, In Suk Sol, Seo Hee Yoon, Min Jung Kim, Kyung Won Kim, Myunghyun Sohn, Kyu-Earn Kim
Theoretical non-linear modeling of exhaled nitric oxide has revealed extended flow-independent parameters that could explain where or how nitric oxide is produced in the lung and transferred to the airway gas stream. We aimed to evaluate the associations of bronchial hyperresponsiveness and bronchodilator response with extended flow-independent nitric oxide parameters. Nitric oxide (30, 50, 100, 200 mL/s) was measured in 432 children with asthma on the same day as either methacholine challenge test (n=156) or spirometry with bronchodilator (n=276; 96 previously diagnosed with asthma and treated with inhaled corticosteroid, 37 with acute exacerbation treated with systemic corticosteroid)...
June 28, 2017: Journal of Breath Research
https://www.readbyqxmd.com/read/28625120/the-effects-of-ramadan-fasting-on-the-spirometric-data-of-healthy-adult-males
#15
Imed Latiri, Siwar Sandid, Mohamed Amine Fennani, Mohamed Hadrich, Tasnim Masmoudi, Chiraz Maatoug, Makrem Zammit-Chatti, Karim Chamari, Helmi Ben Saad
The few studies carried out on the effects of Ramadan fasting (RF) on spirometric values present contradictory conclusions. This study aimed at assessing whether RF affects healthy adults' spirometric values. Twenty-nine nonsmoking healthy males ( M ± standard error of mean [ SEM] of age: 27 ± 1 years) who fasted during Ramadan (June 29-July 28, 2014) volunteered to the study. Three periods (before-Ramadan [June 23-25], mid-Ramadan [July 14-16] and after-Ramadan [August 11-14]) were selected for spirometry measurements that were consistently performed 5...
July 2017: American Journal of Men's Health
https://www.readbyqxmd.com/read/28606216/comparable-reductions-in-hyperpnoea-induced-bronchoconstriction-and-markers-of-airway-inflammation-after-supplementation-with-6%C3%A2-2-and-3%C3%A2-1-g-d-of-long-chain-n-3-pufa-in-adults-with-asthma
#16
Neil C Williams, Kirsty A Hunter, Dominick E Shaw, Kim G Jackson, Graham R Sharpe, Michael A Johnson
Although high dose n-3 PUFA supplementation reduces exercise- and hyperpnoea-induced bronchoconstriction (EIB/HIB), there are concurrent issues with cost, compliance and gastrointestinal discomfort. It is thus pertinent to establish the efficacy of lower n-3 PUFA doses. Eight male adults with asthma and HIB and eight controls without asthma were randomly supplemented with two n-3 PUFA doses (6·2 g/d (3·7 g EPA and 2·5 g DHA) and 3·1 g/d (1·8 g EPA and 1·3 g DHA)) and a placebo, each for 21 d followed by 14 d washout...
May 2017: British Journal of Nutrition
https://www.readbyqxmd.com/read/28592704/the-added-value-of-exhaled-breath-temperature-in-respiratory-medicine
#17
Todor A Popov, Tanya Kralimarkova, Marina Labor, Davor Plavec
Recognition of the huge economic burden chronic respiratory diseases pose for society motivated fundamental and clinical research leading to insight into the role of airway inflammation in various disease entities and their phenotypes. However, no easy, cheap and patient-friendly methods to assess it have found a place in routine clinical practice. Measurement of exhaled breath temperature (EBT) has been suggested as a non-invasive method to detect inflammatory processes in the airways as a result of increased blood flow within the airway walls...
June 8, 2017: Journal of Breath Research
https://www.readbyqxmd.com/read/28592098/-the-effect-of-short-term-exposure-to-ambient-no-2-on-lung-function-and-fractional-exhaled-nitric-oxide-in-33-chronic-obstructive-pulmonary-disease-patients
#18
J Shan, Y Ni, W Dong, J H Xu, L Pan, H Y Li, X Yang, S W Wu, Y H Chen, F R Deng, X B Guo
Objectives: To investigate the effect of short-term exposure to ambient NO(2) has influence on lung function and fractional exhaled nitric oxide (FeNO) in chronic obstructive pulmonary disease (COPD) patients. Methods: A panel of doctor-diagnosed stable COPD patients (n=33) were recruited and repeatedly measured for lung function and FeNO from December 2013 to October 2014. The patients who lived in Beijing for more than one year and aged between 60 and 85 years old were included in the study. We excluded patients with asthma, bronchial tensor, lung cancer and other respiratory disorders other than chronic obstructive pulmonary disease and occupational exposure and chest trauma surgery patients...
June 6, 2017: Zhonghua Yu Fang Yi Xue za Zhi [Chinese Journal of Preventive Medicine]
https://www.readbyqxmd.com/read/28592061/-value-of-forced-expiratory-volume-in-6-seconds-fev-6-in-the-evaluation-of-pulmonary-function-in-chinese-elderly-males
#19
M M Pan, H S Zhang, T Y Sun
Objective: To evaluate the value of forced expiratory volume in 6 seconds (FEV(6)) in the evaluation of pulmonary function in Chinese elderly males. Methods: Pulmonary function tests of elderly who had received regular physical examination in Beijing Hospital from July 2003 to April 2015 were analyzed on subjects with the following characteristics: aged 60 years or older, completion of bronchial dilation test and able to exhale for at least six seconds. The included subjects were divided into 2 groups: 60-<80 years group and ≥80 years group...
May 30, 2017: Zhonghua Yi Xue za Zhi [Chinese medical journal]
https://www.readbyqxmd.com/read/28559470/flow-decay-a-novel-spirometric-index-to-quantify-dynamic-airway-resistance
#20
Anita Oh, Tessa A Morris, Isaac T Yoshii, Timothy A Morris
BACKGROUND: Dynamic airway resistance from obstructive disease causes a concavity in the mid-expiratory portion of the spirometric flow-volume loop. We developed a simple model to measure the exponential decay in air flow during forced exhalation to quantify the extent of dynamic airway obstruction and facilitate the detection of obstructive airway diseases clinically. METHODS: We calculated flow decay as the slope of volume versus ln(1/flow) in mid-exhalation. We derived the normal range in a derivation group of healthy volunteers in whom spirometry had been performed repeatedly...
May 30, 2017: Respiratory Care
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