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https://www.readbyqxmd.com/read/28068290/a-collection-system-for-dry-solid-residues-from-exhaled-breath-for-analysis-via-atomic-force-microscopy
#1
Victor N Morozov, Andrey Y Mikheev
Exhaled air contains sub-micron droplets of lung liquid, which potentially bear biomarkers of lung diseases. After dehydration they form dry residue particles (DRPs). As a first step in developing techniques to characterize individual DRPs, a new electrostatic collector was designed in which DRPs are charged within a unipolar corona charger, concentrated in a cone funnel, and deposited onto a limited area of a highly oriented pyrolytic graphite surface. The collector captures 80%-90% of DRPs at an optimal flow rate of 0...
January 9, 2017: Journal of Breath Research
https://www.readbyqxmd.com/read/28065396/inhaled-corticosteroid-dose-response-in-asthma-should-we-measure-inflammation
#2
William J Anderson, Philip M Short, Sunny Jabbal, Brian J Lipworth
BACKGROUND: Inhaled corticosteroid (ICS) titration in asthma is primarily based on symptoms and pulmonary function. ICSs may not be increased on this basis despite residual airway inflammation. OBJECTIVE: To compare the dose-response relationships of ICSs on measures of pulmonary function, symptoms, and inflammation in patients with persistent asthma. METHODS: We performed a pooled post hoc analysis of 121 patients with mild to moderate asthma from 4 randomized clinical trials that incorporated an ICS dose ramp...
January 3, 2017: Annals of Allergy, Asthma & Immunology
https://www.readbyqxmd.com/read/28056907/lung-function-in-very-low-birth-weight-infants-after-pharmacological-and-surgical-treatment-of-patent-ductus-arteriosus-a-retrospective-analysis
#3
Payman Barikbin, Hannes Sallmon, Silke Wilitzki, Joachim Photiadis, Christoph Bührer, Petra Koehne, Gerd Schmalisch
BACKGROUND: The indications and strategies for treatment of patent ductus arteriosus (PDA) are controversial, and the safety and long-term benefits of surgical PDA closure remain uncertain. The aim of this study was to compare the lung function of very low birth weight (VLBW) infants after successful PDA treatment with a cyclooxygenase inhibitor or secondary surgical ligation. METHODS: A total of 114 VLBW infants (birth weight < 1500 g), including 94 infants (82%) with a birth weight < 1000 g, who received treatment for hemodynamically significant PDA (hsPDA), were examined at a median postmenstrual age of 48 weeks...
January 6, 2017: BMC Pediatrics
https://www.readbyqxmd.com/read/28046287/su-f-j-120-evaluation-of-the-combined-effect-of-body-orientation-and-breathing-on-organ-movement-in-thorax-using-multi-step-deformable-image-registration
#4
C Guy, E Weiss, S Che, W Sleeman, N Mukhopadhyay, M Rosu
PURPOSE: Use deformable registration to map more complex anatomies that include changes associated with both different body positions and breathing, and evaluate the resultant respiratory excursions for tumors and relevant organs at risk. METHODS: Same-day exhale and inhale datasets from prone and supine 4D CT scans of lung cancer patients have been registered using the Elastix software package through a 3 step process: (1) rigid registration for bony alignment (2) deformable multiresolution B-Spline registration of entire anatomy (3) deformable multiresolution B-Spline registration of lung parenchyma (to improve lung vasculature alignment)...
June 2016: Medical Physics
https://www.readbyqxmd.com/read/28038794/prognostic-role-of-exhaled-breath-condensate-ph-and-fraction-exhaled-nitric-oxide-in-systemic-sclerosis-related-interstitial-lung-disease
#5
Alfredo Guillen-Del Castillo, Sara Sánchez-Vidaurre, Carmen P Simeón-Aznar, María J Cruz, Vicente Fonollosa-Pla, Xavier Muñoz
INTRODUCTION: Interstitial lung disease (ILD) is one of the major causes of death in systemic sclerosis (SSc). This study investigated exhaled breath (EB) and exhaled breath condensate (EBC) biomarkers in patients with SSc and analyzed their role as a prognostic tool in SSc-related ILD. METHODS: Fraction exhaled nitric oxide (FeNO) and exhaled carbon monoxide (eCO) measured in EB, together with pH, nitrite, nitrate and interleukin-6 levels measured in EBC were prospectively analyzed in 35 patients with SSc...
December 27, 2016: Archivos de Bronconeumología
https://www.readbyqxmd.com/read/27999150/the-concave-shape-of-the-forced-expiratory-flow-volume-curve-in-3-seconds-is-a-practical-surrogate-of-fev1-fvc-for-the-diagnosis-of-airway-limitation-in-inadequate-spirometry
#6
Hao Li, Chunhong Liu, Yi Zhang, Wei Xiao
BACKGROUND: Spirometry is important for the differential diagnosis of dyspnea. However, some patients cannot exhale for ≥6 s to achieve the American Thoracic Society/European Respiratory Society criteria. The aim of this study was to demonstrate the reliability of a new parameter that quantifies the degree of concavity in the first 3 s to define airway limitation as a surrogate for the FEV1/FVC. METHODS: Four hundred spirometry test results were selected through complete random sampling...
December 20, 2016: Respiratory Care
https://www.readbyqxmd.com/read/27931302/new-insights-into-treatment-of-children-with-exercise-induced-asthma-symptoms
#7
Iwona Stelmach, Anna Sztafiska, Joanna Jerzyska, Daniela Podlecka, Pawe Majak, Wodzimierz Stelmach
BACKGROUND: Exercise is one of the most common triggers of bronchoconstriction and affects up to 80% of children with asthma. OBJECTIVE: The purpose of this randomized, double-blind, placebo-controlled study was to assess the effectiveness of treatment with ciclesonide 160 microgram, either alone, with a higher dose, with a leukotriene receptor antagonist (LTRA), or with a long-acting beta-agonist (LABA) in children with asthma with postexercise-induced symptoms...
November 2016: Allergy and Asthma Proceedings:
https://www.readbyqxmd.com/read/27931291/effects-of-the-addition-of-tiotropium-on-airway-dimensions-in-symptomatic-asthma
#8
Makoto Hoshino, Junichi Ohtawa, Kenta Akitsu
BACKGROUND: Tiotropium, a once-daily, long-acting anticholinergic bronchodilator, has shown efficacy and safety as an add-on to maintenance therapy in patients with symptomatic asthma. OBJECTIVE: The aim of the present study was to assess the effect of tiotropium on airway geometry and airway inflammation in patients with asthma who were symptomatic despite treatment with inhaled corticosteroid (ICS) plus a long-acting beta 2agonist (LABA). METHODS: In total, 53 patients with symptomatic asthma who received ICS plus LABA and who had a prebronchodilator forced expiratory volume in 1 second of 6090% of the predicted value were randomized to the addition of tiotropium 5 g once daily (n = 25) or no add-on (n = 28) to maintenance therapy for 48 weeks...
November 2016: Allergy and Asthma Proceedings:
https://www.readbyqxmd.com/read/27913032/intervention-studies-of-inhaled-corticosteroids-combined-with-long-acting-theophylline-or-long-acting-%C3%AE-2-agonists-in-patients-with-moderate-to-severe-asthma-a-randomized-controlled-study
#9
Yan Wang, Ping Chen, Anna Dai, Shengyun Shang, Lingfei Kong
PURPOSE: To evaluate and contrast the therapeutic effect and safety of fluticasone aerosol combined with theophylline tablets in patients with moderate to severe asthma, compared with salmeterol/fluticasone propionate aerosol. METHODS: After a screening period, patients meeting the inclusion criteria were randomly assigned to the experiment group (fluticasone aerosol combined with theophylline tablets) or the control group (salmeterol/fluticasone aerosol combined with placebo tablets) for 12 weeks of treatment...
December 2016: Clinical Therapeutics
https://www.readbyqxmd.com/read/27884795/forced-oscillation-technique-as-a-predictor-of-fev1-improvement-in-asthma
#10
Taisuke Akamatsu, Toshihiro Shirai, Yukiko Shimoda, Takahito Suzuki, Ichiro Hayashi, Rie Noguchi, Eisuke Mochizuki, Shogo Sakurai, Mika Saigusa, Akito Yamamoto, Yuichiro Shishido, Takefumi Akita, Satoru Morita, Kazuhiro Asada
The usefulness of the forced oscillation technique (FOT) for predicting the treatment outcomes in untreated asthmatic patients is unknown. We investigated whether FOT could predict an improvement in FEV1 following treatment. FOT, spirometry, and fractional exhaled nitric oxide were performed in 31 outpatients before and after undergoing a minimum of two months combination therapy of inhaled corticosteroids and long-acting β2-agonists. The patients were classified as responders or nonresponders to treatment based on the presence or absence of a 10% improvement in the FEV1...
February 2017: Respiratory Physiology & Neurobiology
https://www.readbyqxmd.com/read/27825992/prevalence-determinants-and-clinical-correlates-of-vitamin-d-deficiency-in-adults-with-inhaled-corticosteroid-treated-asthma-in-london-uk
#11
REVIEW
David A Jolliffe, Kate Kilpin, Beverley D MacLaughlin, Claire L Greiller, Richard L Hooper, Neil C Barnes, Peter M Timms, Raj K Rajakulasingam, Angshu Bhowmik, Aklak B Choudhury, David E Simcock, Elina Hyppönen, Christopher J Corrigan, Robert T Walton, Christopher J Griffiths, Adrian R Martineau
Vitamin D deficiency is common in children with asthma, and it associates with poor asthma control, reduced forced expiratory volume in one second (FEV1) and increased requirement for inhaled corticosteroids (ICS). Cross-sectional studies investigating the prevalence, determinants and clinical correlates of vitamin D deficiency in adults with asthma are lacking. We conducted a multi-centre cross-sectional study in 297 adults with a medical record diagnosis of ICS-treated asthma living in London, UK. Details of potential environmental determinants of vitamin D status, asthma control and medication use were collected by questionnaire; blood samples were taken for analysis of serum 25(OH)D concentration and DNA extraction, and participants underwent measurement of weight, height and fractional exhaled nitric oxide concentration (FeNO), spirometry and sputum induction for determination of lower airway eosinophil counts (n=35 sub-group)...
November 5, 2016: Journal of Steroid Biochemistry and Molecular Biology
https://www.readbyqxmd.com/read/27825189/exhaled-nitric-oxide-levels-to-guide-treatment-for-children-with-asthma
#12
REVIEW
Helen L Petsky, Kayleigh M Kew, Anne B Chang
BACKGROUND: Asthma guidelines aim to guide health practitioners to optimise treatment for patients to minimise symptoms, improve or maintain good lung function, and prevent acute exacerbations. The principle of asthma guidelines is based on a step-up or step-down regimen of asthma medications to maximise health using minimum doses. Fractional exhaled nitric oxide (FeNO) is a marker of eosinophilic inflammation and tailoring asthma medications in accordance to airway eosinophilic levels may improve asthma outcomes such as indices of control or reduce exacerbations, or both...
9, 2016: Cochrane Database of Systematic Reviews
https://www.readbyqxmd.com/read/27783458/combined-use-of-fractional-exhaled-nitric-oxide-and-bronchodilator-response-in-predicting-future-loss-of-asthma-control-among-children-with-atopic-asthma
#13
Je-Kyung Kim, Jae-Yub Jung, Heon Kim, Sang-Yong Eom, Youn-Soo Hahn
BACKGROUND AND OBJECTIVE: Recognition of patients at risk of asthma exacerbation is important for future asthma care and improved outcome. The aim of the present study was to see whether measurements of bronchodilator response (BDR) and fractional exhaled nitric oxide (FeNO) in combination provide prognostic information superior to either measurement alone in children with atopic asthma. METHODS: A total of 201 atopic children aged 8-16 years with intermittent or mild persistent asthma were included...
October 26, 2016: Respirology: Official Journal of the Asian Pacific Society of Respirology
https://www.readbyqxmd.com/read/27736038/multidisciplinary-treatment-in-children-with-problematic-severe-asthma-a-prospective-evaluation
#14
Marieke Verkleij, Anita Beelen, Bart E van Ewijk, Rinie Geenen
OBJECTIVE: For children with problematic severe asthma, achieving adequate control of asthma is difficult. The aim of this prospective observational study was to evaluate the effects of intensive multidisciplinary inpatient treatment on multiple outcome variables in children with problematic severe asthma. METHODS: Participants were 89 children with problematic severe asthma (mean age 13.6 ± 2.5 years) treated in tertiary care clinics at high altitude (Switzerland) or sea level (Netherlands) and their parents (85 mothers, 55 fathers)...
October 13, 2016: Pediatric Pulmonology
https://www.readbyqxmd.com/read/27718262/a-12-week-randomized-parallel-group-proof-of-concept-study-of-tulobuterol-patch-and-salmeterol-inhaler-as-add-on-therapy-in-adult-onset-mild-to-moderate-asthma
#15
Hideki Inoue, Akio Niimi, Hisako Matsumoto, Isao Ito, Tsuyoshi Oguma, Kojiro Otsuka, Tomoshi Takeda, Hitoshi Nakaji, Tomoko Tajiri, Toshiyuki Iwata, Tadao Nagasaki, Michiaki Mishima
Patch formulation of tulobuterol has been used in asthma treatment as a long-acting β2 -agonist (LABA) through sustained skin absorption. Its treatment efficacy, especially in small airways, remains poorly understood. The study aim was to investigate LABA add-on effects of tulobuterol patch (TP) and salmeterol inhaler (SA) on pulmonary function, asthma control and health status. Patients who had adult-onset under-control asthma, despite taking inhaled corticosteroids, were enrolled in a randomized, open-label, parallel-group, proof-of-concept study of 12-week add-on treatment with TP (n=16) or SA (n=17)...
January 2017: Clinical and Experimental Pharmacology & Physiology
https://www.readbyqxmd.com/read/27697801/the-effect-of-ivabradine-on-functional-capacity-in-patients-with-chronic-obstructive-pulmonary-disease
#16
Kareem Mahmoud, Hussien Heshmat Kassem, Essam Baligh, Usama ElGameel, Yosri Akl, Hossam Kandil
Increased sympathetic tone and use of bronchodilators increase heart rate and this may worsen functional capacity in patients with chronic obstructive pulmonary disease (COPD). The aim of this study was to look at the short-term effect of the heart rate lowering drug ivabradine on clinical status in COPD patients.We randomised 80 COPD patients with sinus heart rate ≥90 bpm into either taking ivabradine 7.5 mg twice per day or placebo for two weeks. We assessed all patients using the modified Borg scale and 6-minute walk test at baseline and then again 2 weeks after randomisation...
October 2016: Clinical Medicine: Journal of the Royal College of Physicians of London
https://www.readbyqxmd.com/read/27660432/fractional-exhaled-nitric-oxide-levels-in-asthma-copd-overlap-syndrome-analysis-of-the-national-health-and-nutrition-examination-survey-2007-2012
#17
Tadahiro Goto, Carlos A Camargo, Kohei Hasegawa
PURPOSE: Recent studies propose TH2-mediated inflammation in patients with asthma-chronic obstructive pulmonary disease (COPD) overlap syndrome (ACOS). However, little is known about whether fractional exhaled nitric oxide (FeNO) differs between patients with ACOS and those with COPD alone. To address this knowledge gap, a nationally representative sample was analyzed to determine the difference in FeNO levels between patients with ACOS and those with COPD alone in the US population. PATIENTS AND METHODS: This is a cross-sectional analysis of the National Health and Nutrition Examination Survey from 2007 through 2012...
2016: International Journal of Chronic Obstructive Pulmonary Disease
https://www.readbyqxmd.com/read/27649851/clinical-characteristics-of-eosinophilic-asthma-exacerbations
#18
Asger Bjerregaard, Ingrid A Laing, Vibeke Backer, Markus Fally, Siew-Kim Khoo, Glenys Chidlow, Chisha Sikazwe, David W Smith, Peter Le Souëf, Celeste Porsbjerg
BACKGROUND AND OBJECTIVE: Airway eosinophilia is associated with an increased risk of asthma exacerbations; however, the impact on the severity of exacerbations is largely unknown. We describe the sputum inflammatory phenotype during asthma exacerbation and correlate it with severity and treatment response. METHODS: Patients presenting to hospital with an asthma exacerbation were recruited during a 12-month period and followed up after 4 weeks. Induced sputum was collected at both visits...
February 2017: Respirology: Official Journal of the Asian Pacific Society of Respirology
https://www.readbyqxmd.com/read/27625090/living-near-a-major-road-in-beijing-association-with-lower-lung-function-airway-acidification-and-chronic-cough
#19
Zhan-Wei Hu, Yan-Ni Zhao, Yuan Cheng, Cui-Yan Guo, Xi Wang, Nan Li, Jun-Qing Liu, Hui Kang, Guo-Guang Xia, Ping Hu, Ping-Ji Zhang, Jing Ma, Ying Liu, Cheng Zhang, Li Su, Guang-Fa Wang
BACKGROUND: The effects of near-road pollution on lung function in China have not been well studied. We aimed to investigate the effects of long-term exposure to traffic-related air pollution on lung function, airway inflammation, and respiratory symptoms. METHODS: We enrolled 1003 residents aged 57.96 ± 8.99 years living in the Shichahai Community in Beijing. Distances between home addresses and the nearest major roads were measured to calculate home-road distance...
2016: Chinese Medical Journal
https://www.readbyqxmd.com/read/27615041/-comparison-of-effects-of-exhalation-and-inhalation-breathing-exercises-on-pulmonary-function-and-complications-in-elderly-patients-with-upper-abdominal-surgery
#20
Mijee Koo, Sunkyung Hwang
PURPOSE: The purpose of this study was to identify the effects of exhalation breathing exercises using expirometer and that of inhalation breathing exercises using incentive spirometry on pulmonary function and complications in elderly patients with upper-abdominal surgery. METHODS: The research design was a nonequivalent control group non-synchronized design. Participants were 63 patients who underwent upper-abdominal surgery under general anesthesia (32 in experiment group, 31 in control group)...
August 2016: Journal of Korean Academy of Nursing
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