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https://www.readbyqxmd.com/read/29244733/the-association-of-triiodothyronine-to-thyroxine-ratio-with-body-mass-index-in-obese-nigerian-children-and-adolescents
#1
Mathias Abiodun Emokpae, Progress Arhenrhen Obazelu
The interest in the relationship between thyroid dysfunction and obesity is on the increase. This study compares the triiodothyronine-to-thyroxine (T3/T4) ratio in obese and lean children and adolescents, and correlates thyroid hormones with body mass index (BMI) in obese Nigerian children. It is a retrospective study of records of 76 obese children and adolescents with a BMI of 31.7 ± 0.1 kg/m² (26 males aged 10.9 ± 0.35 years, and 50 females aged 10.8 ± 0.4 years) that were referred to the laboratory for thyroid hormone evaluation because of their obese status...
December 15, 2017: Medical Sciences: Open Access Journal
https://www.readbyqxmd.com/read/29238244/influence-of-a-thermogenic-dietary-supplement-on-safety-markers-body-composition-energy-expenditure-muscular-performance-and-hormone-concentrations-a-randomized-placebo-controlled-double-blind-trial
#2
Grant M Tinsley, Stacie Urbina, Jacy Mullins, Jordan Outlaw, Sara Hayward, Matt Stone, Cliffa Foster, Colin Wilborn, Lem Taylor
Dietary supplementation is commonly employed by individuals seeking to improve body composition and exercise performance. The purpose of the present study was to examine the safety and effectiveness of a commercially available dietary supplement designed to promote thermogenesis and fat loss. In a randomized double-blind trial, participants were assigned to consume placebo or a multi-ingredient supplement containing caffeine, green tea extract, l-carnitine, evodiamine and other ingredients that purportedly enhance thermogenesis...
December 2017: Journal of Sports Science & Medicine
https://www.readbyqxmd.com/read/29211883/carcass-characteristics-meat-quality-and-fatty-acid-composition-of-wild-living-mallards-anas-platyrhynchos-l
#3
P Janiszewski, D Murawska, V Hanzal, M Gesek, D Michalik, M Zawacka
The aim of this study was to determine the carcass characteristics, meat quality, and fatty acid composition of wild-living mallards. The experimental materials comprised 30 mallards (1:1 sex ratio) harvested during the hunting season in northeastern Poland. The carcasses were transported to the laboratory where they were weighed individually, plucked, dressed, and dissected. The proximate chemical composition and physicochemical properties of meat and the fatty acid profile of breast muscle lipids were determined, and a histological analysis was performed...
December 2, 2017: Poultry Science
https://www.readbyqxmd.com/read/29189940/the-relationship-between-dietary-protein-content-body-condition-and-%C3%AE-15n-in-a-mammalian-omnivore
#4
Kelli L Hughes, John P Whiteman, Seth D Newsome
Seasonal reductions in food availability may cause animals to catabolize endogenous tissue and the resulting loss of lean mass can hinder their ability to forage and reproduce. While several studies have considered nitrogen isotopes (δ15N) as an indicator of catabolism, relationships between protein intake, body condition, and tissue δ15N have not been assessed simultaneously in controlled conditions. We conducted a feeding experiment on laboratory mice (Mus musculus) to test the effects of low (5%) versus high (30-40%) dietary protein content on lean mass, fat mass, and tissue δ15N...
November 30, 2017: Oecologia
https://www.readbyqxmd.com/read/29153692/effects-of-postpartum-uterine-curettage-in-the-recovery-from-preeclampsia-eclampsia-a-randomized-controlled-trial
#5
Gamaliel Mc Lean, Osvaldo Reyes, Rodrigo Velarde
OBJECTIVE: To evaluate if postpartum uterine curettage improved the clinical and laboratory parameters in patients with preeclampsia or eclampsia. METHODS: A total of 442 patients with preeclampsia/eclampsia were randomized to postpartum curettage (223) or no procedure (219). Systolic and diastolic blood pressure were recorded and analyzed at hours 6, 12, 24 and 48. Also, several laboratory values and diuresis were evaluated. RESULTS: No statistical differences were found between groups (curettage vs...
October 2017: Pregnancy Hypertension
https://www.readbyqxmd.com/read/29112514/effects-of-intravenous-cold-saline-on-hyperthermic-athletes-representative-of-large-football-players-and-small-endurance-runners
#6
Katherine E Morrison, Natasha Desai, Christopher McGuigan, Megan Lennon, Sandra Fowkes Godek
OBJECTIVE: To evaluate the cooling effects of intravenous (IV) cold normal (0.9%) saline on hyperthermic athletes. DESIGN: Randomized crossover study design. SETTING: Controlled research laboratory. PARTICIPANTS: Twelve male participants who were representative of a collegiate cross-country (6) and American football (6) population. INTERVENTIONS: Participants underwent body composition analysis using a BodPod...
October 27, 2017: Clinical Journal of Sport Medicine: Official Journal of the Canadian Academy of Sport Medicine
https://www.readbyqxmd.com/read/29106028/association-of-high-anti-cyclic-citrullinated-peptide-seropositivity-and%C3%A2-lean-mass-index-with-low-bone-mineral-density-in-rheumatoid-arthritis
#7
Katherine D Wysham, Dolores M Shoback, John B Imboden, Patricia P Katz
OBJECTIVE: Osteoporotic fractures are associated with high morbidity and mortality. Persons with rheumatoid arthritis (RA) have twice the risk of osteoporosis-related fracture than age-matched controls, the causes for which remain unknown. We investigated contributions of RA characteristics, medication use, and body composition to low bone mineral density (BMD) in patients with RA. METHODS: Data were from the Arthritis, Body Composition, and Disability Study (n=138; 82 women, 56 men)...
November 5, 2017: Arthritis Care & Research
https://www.readbyqxmd.com/read/29096612/relationships-between-cognitive-function-and-body-composition-among-community-dwelling-older-adults-a-cross-sectional-study
#8
Hye-Mi Noh, Sohee Oh, Hong Ji Song, Eun Young Lee, Jin-Young Jeong, Ohk-Hyun Ryu, Kyung-Soon Hong, Dong-Hyun Kim
BACKGROUND: Previous studies reported mixed results regarding the association between cognition and body weight in late life. We evaluated the relationships between cognitive function and body composition among community-dwelling older adults. METHODS: Three hundred twenty subjects (≥65 years, women 53%) with available data of cognitive function and body composition from 2010 Hallym Aging Study. Cognitive function was assessed using Korean Mini-Mental State Examination (K-MMSE)...
November 2, 2017: BMC Geriatrics
https://www.readbyqxmd.com/read/29058595/world-wide-immunoscore-task-force-meeting-report-from-the-melanoma-bridge-napoli-november-30th-december-3rd-2016
#9
Jerome Galon, Alessandro Lugli, Carlo Bifulco, Franck Pages, Giuseppe Masucci, Francesco M Marincola, Paolo A Ascierto
The predictive accuracy of the traditional staging system is based on disease progression as a tumour cell-autonomous process, but it fails to incorporate the effects of the host immune response. A precise analysis of the immune component of the tumour microenvironment by computer-based analysis may be essential to managing patients better, opening the road to an expertise in this new emerging field. The Immunoscore as a new possible approach in the classification of cancer, designated TNM-Immune, studied in colon cancer patients with predictive and prognostic value...
October 20, 2017: Journal of Translational Medicine
https://www.readbyqxmd.com/read/29050649/obesity-status-influences-the-relationship-among-serum-osteocalcin-iron-stores-and-insulin-sensitivity
#10
Gemma Xifra, José María Moreno-Navarrete, María Moreno, Wifredo Ricart, José Manuel Fernández-Real
BACKGROUND & AIMS: Increased iron stores significantly influence the clinical course of several chronic metabolic diseases. Recent studies have shown that iron overload decreases osteocalcin. We aimed to explore the relationship among osteocalcin, iron stores and insulin sensitivity. METHODS: Extensive clinical and laboratory measurements, including serum ferritin, cross-linked C-telopeptide of type I collagen (CTX) and osteocalcin (OC) concentrations, were analyzed in 250 adult consecutive Caucasian men...
October 6, 2017: Clinical Nutrition: Official Journal of the European Society of Parenteral and Enteral Nutrition
https://www.readbyqxmd.com/read/29046921/pioglitazone-reduces-cold-induced-brown-fat-glucose-uptake-despite-induction-of-browning-in-cultured-human-adipocytes-a-randomised-controlled-trial-in-humans
#11
Rebecca K C Loh, Melissa F Formosa, Nina Eikelis, David A Bertovic, Mitchell J Anderson, Shane A Barwood, Shane Nanayakkara, Neale D Cohen, Andre La Gerche, Anne T Reutens, Kenneth S Yap, Thomas W Barber, Gavin W Lambert, Martin H Cherk, Stephen J Duffy, Bronwyn A Kingwell, Andrew L Carey
AIMS/HYPOTHESIS: Increasing brown adipose tissue (BAT) activity is a possible therapeutic strategy to increase energy expenditure and glucose and lipid clearance to ameliorate obesity and associated comorbidities. The thiazolidinedione (TZD) class of glucose-lowering drugs increase BAT browning in preclinical experimental models but whether these actions extend to humans in vivo is unknown. The aim of this study was to determine the effect of pioglitazone treatment on adipocyte browning and adaptive thermogenesis in humans...
October 18, 2017: Diabetologia
https://www.readbyqxmd.com/read/29043447/-lean-management-in-the-pathology-laboratory
#12
A Blank, H Dawson, C Hammer, A Perren, A Lugli
No abstract text is available yet for this article.
November 2017: Der Pathologe
https://www.readbyqxmd.com/read/28958963/lean-management-and-medical-laboratory-application-in-transfusionnal-immuno-hematology
#13
Jean-Baptiste Thibert, Françoise Le Vacon, Bruno Danic
Despite a common use in industrial applications, only a few studies describe the lean management methods in medical laboratory. These tools have been evaluated in analysis laboratory of blood donors, especially in immuno-hematology sector. The aim was to optimize the organization and maintain team cohesion and strong staff involvement in a restructuring context. The tools used and the results obtained are presented in this study.
October 1, 2017: Annales de Biologie Clinique
https://www.readbyqxmd.com/read/28937782/cold-water-immersion-cooling-rates-in-football-linemen-and-cross-country-runners-with-exercise-induced-hyperthermia
#14
Sandra Fowkes Godek, Katherine E Morrison, Gregory Scullin
CONTEXT:   Ideal and acceptable cooling rates in hyperthermic athletes have been established in average-sized participants. Football linemen (FBs) have a small body surface area (BSA)-to-mass ratio compared with smaller athletes, which hinders heat dissipation. OBJECTIVE:   To determine cooling rates using cold-water immersion in hyperthermic FBs and cross-country runners (CCs). DESIGN:   Cohort study. SETTING:   Controlled university laboratory...
October 2017: Journal of Athletic Training
https://www.readbyqxmd.com/read/28912902/effects-of-dapagliflozin-on-body-composition-and-liver-tests-in-patients-with-nonalcoholic-steatohepatitis-associated-with-type-2-diabetes-mellitus-a-prospective-open-label-uncontrolled-study
#15
Hiroshi Tobita, Shuichi Sato, Tatsuya Miyake, Shunji Ishihara, Yoshikazu Kinoshita
BACKGROUND: Nonalcoholic steatohepatitis (NASH) is an active form of nonalcoholic fatty liver disease. Risk factors for NASH include type 2 diabetes mellitus (T2DM) and obesity. Sodium-glucose cotransporter 2 (SGLT2) inhibitors used to treat T2DM prevent glucose reabsorption in the kidney and increase glucose urinary excretion. Dapagliflozin is a potent, selective SGLT2 inhibitor that reduces hyperglycemia in patients with T2DM and has been demonstrated to reduce some complications associated with NASH in rodent models...
2017: Current Therapeutic Research, Clinical and Experimental
https://www.readbyqxmd.com/read/28905722/calculation-of-glucose-dose-for-intraperitoneal-glucose-tolerance-tests-in-lean-and-obese-mice
#16
Mikkel S Jørgensen, Kristina S Tornqvist, Henning Hvid
Glucose tolerance tests are used frequently in nonclinical research with laboratory animals, for example during characterization of obese phenotypes. Despite published standard operating procedures for glucose tolerance tests in rodents, how glucose doses should be calculated when obese and lean animals are compared is not well documented. Typically the glucose dose is calculated as 2 g/kg body weight, regardless of body composition. With this approach, obese mice receive larger glucose doses than do lean animals, potentially leading to overestimation of glucose intolerance in obese animals...
January 1, 2017: Journal of the American Association for Laboratory Animal Science: JAALAS
https://www.readbyqxmd.com/read/28877894/later-circadian-timing-of-food-intake-is-associated-with-increased-body-fat
#17
Andrew W McHill, Andrew Jk Phillips, Charles A Czeisler, Leigh Keating, Karen Yee, Laura K Barger, Marta Garaulet, Frank Ajl Scheer, Elizabeth B Klerman
Background: Weight gain and obesity have reached alarming levels. Eating at a later clock hour is a newly described risk factor for adverse metabolic health; yet, how eating at a later circadian time influences body composition is unknown. Using clock hour to document eating times may be misleading owing to individual differences in circadian timing relative to clock hour.Objective: This study examined the relations between the timing of food consumption relative to clock hour and endogenous circadian time, content of food intake, and body composition...
November 2017: American Journal of Clinical Nutrition
https://www.readbyqxmd.com/read/28870249/improving-emergency-department-radiology-transportation-time-a-successful-implementation-of-lean-methodology
#18
Eveline A Hitti, Ghada R El-Eid, Hani Tamim, Rana Saleh, Miriam Saliba, Lena Naffaa
BACKGROUND: Emergency Department overcrowding has become a global problem and a growing safety and quality concern. Radiology and laboratory turnaround time, ED boarding and increased ED visits are some of the factors that contribute to ED overcrowding. Lean methods have been used in the ED to address multiple flow challenges from improving door-to-doctor time to reducing length of stay. The objective of this study is to determine the effectiveness of using Lean management methods on improving Emergency Department transportation times for plain radiography...
September 5, 2017: BMC Health Services Research
https://www.readbyqxmd.com/read/28821636/twenty-four-hour-rhythmicity-of-circulating-metabolites-effect-of-body-mass-and-type-2-diabetes
#19
Cheryl M Isherwood, Daan R Van der Veen, Jonathan D Johnston, Debra J Skene
Metabolic profiling of individuals with type 2 diabetes mellitus (T2DM) has previously been limited to single-time-point samples, ignoring time-of-day variation. Here, we tested our hypothesis that body mass and T2DM affect daily rhythmicity and concentrations of circulating metabolites across a 24-h day in 3 age-matched, male groups-lean, overweight/obese (OW/OB), and OW/OB with T2DM-in controlled laboratory conditions, which were not confounded by large meals. By using targeted liquid chromatography/mass spectrometry metabolomics, we quantified 130 plasma metabolites every 2 h over 24 h, and we show that average metabolite concentrations were significantly altered by increased body mass (90 of 130) and T2DM (56 of 130)...
August 18, 2017: FASEB Journal: Official Publication of the Federation of American Societies for Experimental Biology
https://www.readbyqxmd.com/read/28805979/effects-of-mtor-inhibition-on-cardiac-and-adipose-tissue-pathology-and-glucose-metabolism-in-rats-with-metabolic-syndrome
#20
Ayako Uchinaka, Mamoru Yoneda, Yuichiro Yamada, Toyoaki Murohara, Kohzo Nagata
The mammalian target of rapamycin (mTOR) is a regulator of metabolism and is implicated in pathological conditions such as obesity and diabetes. We aimed to investigate the role of mTOR in obesity. A new animal model of metabolic syndrome (MetS), named DahlS.Z-Lepr(fa) /Lepr(fa) (DS/obese) rats was established previously in our laboratory. In this study, we used this model to evaluate the effects of mTOR inhibition on cardiac and adipose tissue pathology and glucose metabolism. DS/obese rats were treated with the mTOR inhibitor, everolimus, (0...
August 2017: Pharmacology Research & Perspectives
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