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adult cerebral palsy

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https://www.readbyqxmd.com/read/29341797/visual-dependence-affects-postural-sway-responses-to-continuous-visual-field-motion-in-individuals-with-cerebral-palsy
#1
Yawen Yu, Richard T Lauer, Carole A Tucker, Elizabeth D Thompson, Emily A Keshner
The current study aimed to explore the impact of visual dependence on sensorimotor coupling of postural sway and visual motion in adults and teens with spastic cerebral palsy (CP). We hypothesized that individuals with CP would exhibit greater magnitudes of sway than healthy individuals, and the presence of visual dependence (VD) would produce instability in the direction of visual motion. Participants stood in a virtual environment in which the visual scene remained static or continuously rotated 30 degree/second in pitch-up or pitch-down...
January 17, 2018: Developmental Neurorehabilitation
https://www.readbyqxmd.com/read/29339922/effect-of-rhythmic-auditory-cueing-on-gait-in-cerebral-palsy-a-systematic-review-and-meta-analysis
#2
REVIEW
Shashank Ghai, Ishan Ghai, Alfred O Effenberg
Auditory entrainment can influence gait performance in movement disorders. The entrainment can incite neurophysiological and musculoskeletal changes to enhance motor execution. However, a consensus as to its effects based on gait in people with cerebral palsy is still warranted. A systematic review and meta-analysis were carried out to analyze the effects of rhythmic auditory cueing on spatiotemporal and kinematic parameters of gait in people with cerebral palsy. Systematic identification of published literature was performed adhering to Preferred Reporting Items for Systematic Reviews and Meta-Analyses and American Academy for Cerebral Palsy and Developmental Medicine guidelines, from inception until July 2017, on online databases: Web of Science, PEDro, EBSCO, Medline, Cochrane, Embase and ProQuest...
2018: Neuropsychiatric Disease and Treatment
https://www.readbyqxmd.com/read/29337004/quantitative-sensory-testing-profiles-in-children-adolescents-and-young-adults-6-20-years-with-cerebral-palsy-hints-for-a-neuropathic-genesis-of-pain-syndromes
#3
M Blankenburg, J Junker, G Hirschfeld, E Michel, F Aksu, J Wager, B Zernikow
INTRODUCTION: Many patients with cerebral palsy (CP) suffer chronic pain as one of the most limiting factors in their quality of life. In CP patients, pain mechanisms are not well understood, and pain therapy remains a challenge. Quantitative sensory testing (QST) might provide unique information about the functional status of the somatosensory system and therefore better guide pain treatment. OBJECTIVES: To understand better the underlying pain mechanisms in pediatric CP patients, we aimed to assess clinical and pain parameters, as well as QST profiles, which were matched to the patients' cerebral imaging pathology...
December 30, 2017: European Journal of Paediatric Neurology: EJPN
https://www.readbyqxmd.com/read/29327313/reduction-of-pain-sensitivity-after-somatosensory-therapy-in-children-with-autism-spectrum-disorders
#4
Inmaculada Riquelme, Samar M Hatem, Pedro Montoya
Children with autism spectrum disorders (ASD) often present with somatosensory dysfunction including an abnormal reactivity to tactile stimuli and altered pain perception. A therapy based on somatosensory stimuli has shown effectiveness in reducing pain sensitivity among adults with cerebral palsy. The present study aims at exploring the influence of somatosensory therapy on somatosensory parameters in children with ASD. Children with high-functioning ASD were randomly assigned to either the intervention (n = 29) or the control group (n = 30)...
January 12, 2018: Journal of Abnormal Child Psychology
https://www.readbyqxmd.com/read/29295638/postural-asymmetry-in-non-ambulant-adults-with-cerebral-palsy-a-scoping-review
#5
Carlee Holmes, Kim Brock, Prue Morgan
PURPOSE: Non-ambulant adults with cerebral palsy are vulnerable to development of postural asymmetry and associated complications. The primary aim of this scoping review was to identify postural deformities in non-ambulant adults with cerebral palsy. MATERIALS AND METHODS: Comprehensive searches were undertaken in EMBASE, CINAHL, AMED, Cochrane, Psych INFO, and Joanna Briggs (1986-Jan 2017), supplemented by hand searching. Two reviewers independently extracted data using a customised tool focusing on study design, participant characteristics, postural descriptors, measurement tools, and interventions...
January 2, 2018: Disability and Rehabilitation
https://www.readbyqxmd.com/read/29288070/neonatal-erythropoietin-mitigates-impaired-gait-social-interaction-and-diffusion-tensor-imaging-abnormalities-in-a-rat-model-of-prenatal-brain-injury
#6
Shenandoah Robinson, Christopher J Corbett, Jesse L Winer, Lindsay A S Chan, Jessie R Maxwell, Christopher V Anstine, Tracylyn R Yellowhair, Nicholas A Andrews, Yirong Yang, Laurel O Sillerud, Lauren L Jantzie
Children who are born preterm are at risk for encephalopathy of prematurity, a leading cause of cerebral palsy, cognitive delay and behavioral disorders. Current interventions are limited and none have been shown to reverse cognitive and behavioral impairments, a primary determinant of poor quality of life for these children. Moreover, the mechanisms of perinatal brain injury that result in functional deficits and imaging abnormalities in the mature brain are poorly defined, limiting the potential to target interventions to those who may benefit most...
December 26, 2017: Experimental Neurology
https://www.readbyqxmd.com/read/29284423/the-relationship-between-lower-limb-muscle-volume-and-body-mass-in-ambulant-individuals-with-bilateral-cerebral-palsy
#7
Jonathan J Noble, Emily Chruscikowski, Nicola R D Fry, Andrew P Lewis, Martin Gough, Adam P Shortland
BACKGROUND: Individuals with cerebral palsy have smaller muscle volumes normalised to body mass than their typically developing peers. The aim of this study is to investigate the relationship between lower limb muscle volume and body mass in young people with bilateral cerebral palsy and their typically developing peers. METHODS: Twenty-five participants with bilateral cerebral palsy (aged 14.7±3.0 years, GMFCS level I-III) and 25 of their typically developing peers (aged 16...
December 29, 2017: BMC Neurology
https://www.readbyqxmd.com/read/29284178/what-is-the-current-practice-of-therapists-in-the-measurement-of-somatosensation-in-children-with-cerebral-palsy-and-other-neurological-disorders
#8
Corrin Walmsley, Susan Taylor, Timothy Parkins, Leeanne Carey, Sonya Girdler, Catherine Elliott
BACKGROUND/AIM: Somatosensation is the ability to detect and recognise body sensations such as touch, vibration, pressure, pain, temperature and proprioception. Cerebral palsy is a neurological disorder that is often accompanied by impairments in somatosensation. Current somatosensory assessments have limited psychometrics established for use with these children. The aim of this study was to identify therapists' current practice and perspectives related to the assessment of somatosensation in children with neurological disorders...
December 28, 2017: Australian Occupational Therapy Journal
https://www.readbyqxmd.com/read/29277025/fatigue-quality-of-life-and-walking-ability-in-adults-with-cerebral-palsy
#9
Sofia Lundh, Salmir Nasic, Jacques Riad
INTRODUCTION: Few studies on fatigue, quality of life and walking ability in adults with cerebral palsy (CP) are available. It is unclear whether these variables are associated. AIM: The aim was to study the influence of CP on fatigue, quality of life, and gait of adult patients. MATERIAL AND METHODS: Three-dimensional gait analysis was performed on 24 women and 26 men, mean age 32.1 (range 21.7-67.2), 23 with unilateral and 27 with bilateral CP...
December 16, 2017: Gait & Posture
https://www.readbyqxmd.com/read/29247458/the-tyneside-pegboard-test-development-validation-and-observations-in-unilateral-cerebral-palsy
#10
Anna P Basu, Emma V Kirkpatrick, Blythe Wright, Janice E Pearse, Kate E Best, Janet A Eyre
AIM: The aims of this study were twofold: first, to develop and validate a timed test of unimanual and bimanual dexterity suitable for those with disability affecting hand function; second, to explore relationships between unimanual and bimanual completion times. METHOD: We developed the Tyneside Pegboard Test (TPT), an electronically timed test with three peg sizes, incorporating an asymmetrical bimanual task. Nine hundred and seventy-four participants (455 males, 519 females; age range 4-80y) provided normative data...
December 16, 2017: Developmental Medicine and Child Neurology
https://www.readbyqxmd.com/read/29244098/clemastine-rescues-myelination-defects-and-promotes-functional-recovery-in-hypoxic-brain-injury
#11
Bruce A C Cree, Jianqin Niu, Kimberly K Hoi, Chao Zhao, Scott D Caganap, Roland G Henry, Dang Q Dao, Daniel R Zollinger, Feng Mei, Yun-An A Shen, Robin J M Franklin, Erik M Ullian, Lan Xiao, Jonah R Chan, Stephen P J Fancy
Hypoxia can injure brain white matter tracts, comprised of axons and myelinating oligodendrocytes, leading to cerebral palsy in neonates and delayed post-hypoxic leukoencephalopathy (DPHL) in adults. In these conditions, white matter injury can be followed by myelin regeneration, but myelination often fails and is a significant contributor to fixed demyelinated lesions, with ensuing permanent neurological injury. Non-myelinating oligodendrocyte precursor cells are often found in lesions in plentiful numbers, but fail to mature, suggesting oligodendrocyte precursor cell differentiation arrest as a critical contributor to failed myelination in hypoxia...
December 13, 2017: Brain: a Journal of Neurology
https://www.readbyqxmd.com/read/29238959/cognition-in-childhood-dystonia-a-systematic-review
#12
REVIEW
Maraike A Coenen, Hendriekje Eggink, Marina A Tijssen, Jacoba M Spikman
AIM: Cognitive impairments have been established as part of the non-motor phenomenology of adult dystonia. In childhood dystonia, the extent of cognitive impairments is less clear. This systematic review aims to present an overview of the existing literature to elucidate the cognitive profile of primary and secondary childhood dystonia. METHOD: Studies focusing on cognition in childhood dystonia were searched in MEDLINE and PsychInfo up to October 2017. We included studies on idiopathic and genetic forms of dystonia as well as dystonia secondary to cerebral palsy and inborn errors of metabolism...
December 14, 2017: Developmental Medicine and Child Neurology
https://www.readbyqxmd.com/read/29190010/are-mechanically-sensitive-regulators-involved-in-the-function-and-patho-physiology-of-cerebral-palsy-related-contractures
#13
Jessica Pingel, Frank Suhr
Skeletal muscle tissue is mechanosensitive, as it is able to sense mechanical impacts and to translate these into biochemical signals making the tissue adapt. Among its mechanosensitive nature, skeletal muscle tissue is the largest metabolic organ of the human body. Disturbances in skeletal muscle mechanosensing and metabolism cause and contribute to many diseases, i.e. muscular dystrophies/myopathies, cardiovascular diseases, COPD or diabetes mellitus type 2. A less commonly focused muscle-related disorder is clinically known as muscle contractures that derive from cerebral palsy (CP) conditions in young and adults...
November 30, 2017: Journal of Muscle Research and Cell Motility
https://www.readbyqxmd.com/read/29186196/the-integration-of-probabilistic-information-during-sensorimotor-estimation-is-unimpaired-in-children-with-cerebral-palsy
#14
Claire Chambers, Taegh Sokhey, Deborah Gaebler-Spira, Konrad P Kording
BACKGROUND: It is important to understand the motor deficits of children with Cerebral Palsy (CP). Our understanding of this motor disorder can be enriched by computational models of motor control. One crucial stage in generating movement involves combining uncertain information from different sources, and deficits in this process could contribute to reduced motor function in children with CP. Healthy adults can integrate previously-learned information (prior) with incoming sensory information (likelihood) in a close-to-optimal way when estimating object location, consistent with the use of Bayesian statistics...
2017: PloS One
https://www.readbyqxmd.com/read/29176957/manual-dexterity-and-intralimb-coordination-assessment-to-distinguish-different-levels-of-impairment-in-boccia-players-with-cerebral-palsy
#15
Alba Roldan, Rafael Sabido, David Barbado, Carla Caballero, Raúl Reina
Background: Boccia is a paralympic sport played by athletes with severe neurological impairments affecting all four limbs. Impaired manual dexterity (MD) and intralimb coordination (ILC) may limit individuals' ability to perform certain activities such as grasping, releasing, or manipulating objects, which are essential tasks for daily life or to participate in para sports such as boccia. However, there are currently no specific instruments available to assess hand-arm coordination in boccia players with severe cerebral palsy (CP)...
2017: Frontiers in Neurology
https://www.readbyqxmd.com/read/29167992/slow-correction-of-severe-spastic-hyperlordosis-in-an-adult-by-means-of-magnetically-expandable-rods
#16
Christof Birkenmaier, Melvin D'Anastasi, Bernd Wegener, Carolin Melcher
BACKGROUND: We describe a case of severe and progressive lumbar hyperlordosis (160°) in a 28-year-old female university student with cerebral palsy. Her main complaints were abdominal wall pain and increasing inability to sit in her custom wheelchair. METHOD: When deciding on our opinion about the most promising treatment strategy, we contemplated slow continued correction by means of percutaneously expandable magnetic rods (MAGEC) after the index surgery as a key component of a satisfactory correction in this severe and rigid curve...
November 22, 2017: European Spine Journal
https://www.readbyqxmd.com/read/29159041/white-matter-alterations-and-their-associations-with-motor-function-in-young-adults-born-preterm-with-very-low-birth-weight
#17
Ingrid Marie Husby Hollund, Alexander Olsen, Jon Skranes, Ann-Mari Brubakk, Asta K Håberg, Live Eikenes, Kari Anne I Evensen
Very low birth weight (VLBW: ≤ 1500 g) individuals have an increased risk of white matter alterations and neurodevelopmental problems, including fine and gross motor problems. In this hospital-based follow-up study, the main aim was to examine white matter microstructure and its relationship to fine and gross motor function in 31 VLBW young adults without cerebral palsy compared with 31 term-born controls, at mean age 22.6 ± 0.7 years. The participants were examined with tests of fine and gross motor function (Trail Making Test-5: TMT-5, Grooved Pegboard, Triangle from Movement Assessment Battery for Children-2: MABC-2 and High-level Mobility Assessment Tool: HiMAT) and diffusion tensor imaging (DTI)...
2018: NeuroImage: Clinical
https://www.readbyqxmd.com/read/29123403/effects-of-short-term-piano-training-on-measures-of-finger-tapping-somatosensory-perception-and-motor-related-brain-activity-in-patients-with-cerebral-palsy
#18
Ana Alves-Pinto, Stefan Ehrlich, Gordon Cheng, Varvara Turova, Tobias Blumenstein, Renée Lampe
Playing a musical instrument demands the integration of sensory and perceptual information with motor processes in order to produce a harmonic musical piece. The diversity of brain mechanisms involved and the joyful character of playing an instrument make musical instrument training a potential vehicle for neurorehabilitation of motor skills in patients with cerebral palsy (CP). This clinical condition is characterized by motor impairments that can affect, among others, manual function, and limit severely the execution of basic daily activities...
2017: Neuropsychiatric Disease and Treatment
https://www.readbyqxmd.com/read/29105760/should-the-gross-motor-function-classification-system-be-used-for-children-who-do-not-have-cerebral-palsy
#19
REVIEW
Megan Towns, Peter Rosenbaum, Robert Palisano, F Virginia Wright
This literature review addressed four questions. (1) In which populations other than cerebral palsy (CP) has the Gross Motor Function Classification System (GMFCS) been applied? (2) In what types of study, and why was it used? (3) How was it modified to facilitate these applications? (4) What justifications and evidence of psychometric adequacy were used to support its application? A search of PubMed, MEDLINE, and Embase databases (January 1997 to April 2017) using the terms: 'GMFCS' OR 'Gross Motor Function Classification System' yielded 2499 articles...
November 5, 2017: Developmental Medicine and Child Neurology
https://www.readbyqxmd.com/read/29100187/mechanical-muscle-and-tendon-properties-of-the-plantar-flexors-are-altered-even-in-highly-functional-children-with-spastic-cerebral-palsy
#20
Annika Kruse, Christian Schranz, Martin Svehlik, Markus Tilp
BACKGROUND: Recent ultrasound studies found increased passive muscle stiffness and no difference in tendon stiffness in highly impaired children and young adults with cerebral palsy. However, it is not known if muscle and tendon mechanical properties are already altered in highly functional children with cerebral palsy. Therefore, the purpose of this study was to compare the mechanical and material properties of the plantar flexors in highly functional children with cerebral palsy and typically developing children...
October 28, 2017: Clinical Biomechanics
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