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https://www.readbyqxmd.com/read/28105874/participation-and-the-gradual-path-to-a-better-life-for-autistic-people
#1
James Cusack
No abstract text is available yet for this article.
February 2017: Autism: the International Journal of Research and Practice
https://www.readbyqxmd.com/read/28105642/what-do-popular-youtube-tm-videos-say-about-vaccines
#2
C H Basch, P Zybert, R Reeves, C E Basch
BACKGROUND: The unregulated social network YouTube(TM) has become an increasingly popular source of information on health topics such as vaccine safety. With a reach of over one billion users per month, the potential for misinformation is significant. METHODS: Using the keywords 'vaccine safety' and 'vaccines and children', 87 of the most widely viewed YouTube(TM) videos were identified and analyzed for content, author status and view count. RESULTS: The range of view counts was 25 532 to 6 229 835, with a median of 62 075 views per video...
January 19, 2017: Child: Care, Health and Development
https://www.readbyqxmd.com/read/28104555/something-to-talk-about-gossip-increases-oxytocin-levels-in-a-near-real-life-situation
#3
Natascia Brondino, Laura Fusar-Poli, Pierluigi Politi
Gossip is a pervasive social behavior. Its evolutionary survival seems related to its social functions, such as establishing group rules, punishing trespassers, exercising social influence through reputational systems, and developing and strengthening social bonds. We aimed at evaluating the effect of gossip on hormones (oxytocin and cortisol) and at identifying potential mediators of hormonal response to gossip. Twenty-two female students were randomly assigned to a gossip conversation or to an emotional non-gossip conversation...
January 4, 2017: Psychoneuroendocrinology
https://www.readbyqxmd.com/read/28104412/features-of-the-broader-autism-phenotype-in-people-with-epilepsy-support-shared-mechanisms-between-epilepsy-and-autism-spectrum-disorder
#4
REVIEW
Annie E Richard, Ingrid E Scheffer, Sarah J Wilson
RICHARD, A.E., I.E. Scheffer and S.J. Wilson. Features of the broader autism phenotype in people with epilepsy support shared mechanisms between epilepsy and autism spectrum disorder. NEUROSCI BIOBEHAV REV 21(1) XXX-XXX, 2016.- To inform on mechanisms underlying the comorbidity of epilepsy and autism spectrum disorder (ASD), we conducted meta-analyses to test whether impaired facial emotion recognition (FER) and theory of mind (ToM), key phenotypic traits of ASD, are more common in people with epilepsy (PWE) than controls...
January 16, 2017: Neuroscience and Biobehavioral Reviews
https://www.readbyqxmd.com/read/28104272/-preventing-carer-burnout
#5
REVIEW
Isabelle de Montety, Edgar Moussaoui, Jean-Marc Baleyte
The issue of the burnout of carers of disabled family members has been raising concern for several years. It is essential to identify the signs of suffering in the carer in order to put in place adapted support which will also be beneficial for the person being cared for. Autism, a disability which has a significant impact on the family circle, is an example of a condition for which providing support to carers is essential.
January 2017: Soins. Pédiatrie, Puériculture
https://www.readbyqxmd.com/read/28104056/psychological-distress-in-jordanian-parents-of-children-with-autism-spectrum-disorder-the-role-of-positive-reappraisal-coping
#6
Ahmad Rayan, Muayyad Ahmad
BACKGROUND: Parents of children with autism spectrum disorder (ASD) frequently report poor psychological well-being. Positive reappraisal coping (PRC) is a coping strategy which offers a protective effect from anxiety and depression. However, the association between PRC and the psychological distress in parents of children with ASD has yet to be established. AIM: This study examines the association between PRC and the psychological distress in parents of children with ASD...
February 2017: Archives of Psychiatric Nursing
https://www.readbyqxmd.com/read/28103059/re-worsening-psychosis-after-fever-of-unknown-origin-in-an-adolescent-boy-with-autism-by-huynh-et-al-j-child-adolesc-psychopharmacol-2013-23-224-227
#7
Keith Fluegge
No abstract text is available yet for this article.
January 19, 2017: Journal of Child and Adolescent Psychopharmacology
https://www.readbyqxmd.com/read/28102992/environmental-factors-associated-with-autism-spectrum-disorder-a-scoping-review-for-the-years-2003-2013
#8
M Ng, J G de Montigny, M Ofner, M T Do
INTRODUCTION: The number of children diagnosed with autism spectrum disorder (ASD) has been rapidly rising in the past decade. The etiology of this disorder, however, is largely unknown, although the environmental relative to the genetic contribution is substantial. We conducted a scoping review to comprehensively assess the current state of knowledge of the environmental factors present from preconception to early life associated with ASD, and to identify research gaps. METHODS: We searched electronic databases MEDLINE, PsycINFO and ERIC for articles on potential risk factors or protective factors from the physical and social environments associated with ASD and its subclassifications published between 1 January, 2003, and 12 July, 2013...
January 2017: Health Promotion and Chronic Disease Prevention in Canada
https://www.readbyqxmd.com/read/28102641/evidence-of-a-reduction-over-time-in-the-behavioral-severity-of-autistic-disorder-diagnoses
#9
Andrew J O Whitehouse, Matthew N Cooper, Keely Bebbington, Gail Alvares, Ashleigh Lin, John Wray, Emma J Glasson
The increasing prevalence of Autism Spectrum Disorders (ASD) may in part be due to a shift in the diagnostic threshold that has led to individuals with a less severe behavioral phenotype receiving a clinical diagnosis. This study examined whether there were changes over time in the qualitative and quantitative phenotype of individuals who received the diagnosis of Autistic Disorder. Data were from a prospective register of new diagnoses in Western Australia (n = 1252). From 2000 to 2006, we examined differences in both the percentage of newly diagnosed cases that met each criterion as well as severity ratings of the behaviors observed (not met, partially met, mild/moderate and extreme)...
January 19, 2017: Autism Research: Official Journal of the International Society for Autism Research
https://www.readbyqxmd.com/read/28102566/annual-research-review-understudied-populations-within-the-autism-spectrum-current-trends-and-future-directions-in-neuroimaging-research
#10
REVIEW
Allison Jack, Kevin A Pelphrey
BACKGROUND: Autism spectrum disorders (ASDs) are a heterogeneous group of neurodevelopmental conditions that vary in both etiology and phenotypic expression. Expressions of ASD characterized by a more severe phenotype, including autism with intellectual disability (ASD + ID), autism with a history of developmental regression (ASD + R), and minimally verbal autism (ASD + MV) are understudied generally, and especially in the domain of neuroimaging. However, neuroimaging methods are a potentially powerful tool for understanding the etiology of these ASD subtypes...
January 19, 2017: Journal of Child Psychology and Psychiatry, and Allied Disciplines
https://www.readbyqxmd.com/read/28102493/a-meta-analysis-of-working-memory-impairments-in-autism-spectrum-disorders
#11
REVIEW
Ya Wang, Yi-Bing Zhang, Lu-Lu Liu, Ji-Fang Cui, Jing Wang, David H K Shum, Therese van Amelsvoort, Raymond C K Chan
Autism spectrum disorders (ASD) are characterized by executive dysfunction, and working memory (WM) comprises one core component of executive function. Many studies have investigated WM impairments in individuals with ASD, however, a conclusive agreement has not been reached. The present study provided a meta-analytic review of WM impairments in individuals with ASD and evaluated potential moderating variables of this problem. Twenty-eight studies were included in this study, and the participants comprised 819 individuals with ASD and 875 healthy controls...
January 19, 2017: Neuropsychology Review
https://www.readbyqxmd.com/read/28102228/maternal-immune-activation-causes-behavioral-impairments-and-altered-cerebellar-cytokine-and-synaptic-protein-expression
#12
Gurudutt Pendyala, Shinnyi Chou, Yoosun Jung, Pierluca Coiro, Elizabeth Spartz, Ragunathan Padmashri, Ming Li, Anna Dunaevsky
Emerging epidemiology studies indicate that maternal immune activation (MIA) resulting from inflammatory stimuli such as viral or bacterial infections during pregnancy serves as a risk factor for multiple neurodevelopmental disorders including autism spectrum disorders and schizophrenia. Although alterations in the cortex and hippocampus of MIA offspring have been described, less evidence exists on the impact on the cerebellum. Here, we report altered expression of cytokines and chemokines in the cerebellum of MIA offspring, including increase in the neuroinflammatory cytokine TNF-α and its receptor TNFR1...
January 19, 2017: Neuropsychopharmacology: Official Publication of the American College of Neuropsychopharmacology
https://www.readbyqxmd.com/read/28102151/pleiotropic-genetic-effects-influencing-sleep-and-neurological-disorders
#13
REVIEW
Olivia J Veatch, Brendan T Keenan, Philip R Gehrman, Beth A Malow, Allan I Pack
Research evidence increasingly points to the large impact of sleep disturbances on public health. Many aspects of sleep are heritable and genes influencing traits such as timing, EEG characteristics, sleep duration, and response to sleep loss have been identified. Notably, large-scale genome-wide analyses have implicated numerous genes with small effects on sleep timing. Additionally, there has been considerable progress in the identification of genes influencing risk for some neurological sleep disorders. For restless legs syndrome, implicated variants are typically in genes associated with neuronal development...
February 2017: Lancet Neurology
https://www.readbyqxmd.com/read/28101892/an-assessment-of-differential-reinforment-procedures-for-learners-with-autism-spectrum-disorder
#14
Kate A Johnson, Jason C Vladescu, Tiffany Kodak, Tina M Sidener
Differential reinforcement procedures may promote unprompted correct responding, resulting in a quicker transfer of stimulus control than nondifferential reinforcement. Recent studies that have compared reinforcement arrangements have found that the most effective arrangement may differ across participants. The current study conducted an assessment of differential reinforcement arrangements (i.e., quality, schedule, and magnitude) and nondifferential reinforcement to identify the most effective arrangement for each participant...
January 19, 2017: Journal of Applied Behavior Analysis
https://www.readbyqxmd.com/read/28101845/feasibility-acceptability-and-preliminary-treatment-outcomes-in-a-school-based-cbt-intervention-program-for-adolescents-with-asd-and-anxiety-in-singapore
#15
Irene E Drmic, Mariam Aljunied, Judy Reaven
Adolescents with autism spectrum disorder (ASD) are at high risk for anxiety difficulties and disorders. Clinic-based cognitive behavioral therapy (CBT) is effective; however, few published school-based CBT programs for youth with ASD exist. In this study, the Facing Your Fears CBT protocol was adapted for delivery and piloted within a school setting by non-clinicians, with culturally appropriate adaptations. 44 13-15 aged youth with ASD from 22 mainstream schools in Singapore participated. Feasibility, acceptability and preliminary treatment outcomes were examined...
January 18, 2017: Journal of Autism and Developmental Disorders
https://www.readbyqxmd.com/read/28101829/autism-spectrum-disorders%C3%A2-diagnosis-and-management
#16
REVIEW
Sharmila Banerjee Mukherjee
Autism Spectrum Disorder (ASD) is a neuro-developmental disorder commonly seen in children. It is characterized by age inappropriate, impaired social communication and the presence of stereotypic behavior. This disorder is hypothesized to result from cerebral dysfunction arising from a complex interaction between genetic, epigenetic and environmental factors. ASD should be suspected in children failing ASD specific screening tests, in the presence of red flags in social, language and/or play domains, in children with developmental or language delay, abnormal behavior, poor school performance or in those who are at high risk...
January 19, 2017: Indian Journal of Pediatrics
https://www.readbyqxmd.com/read/28101530/integrative-analysis-of-disease-signatures-shows-inflammation-disrupts-juvenile-experience-dependent-cortical-plasticity
#17
Milo R Smith, Poromendro Burman, Masato Sadahiro, Brian A Kidd, Joel T Dudley, Hirofumi Morishita
Throughout childhood and adolescence, periods of heightened neuroplasticity are critical for the development of healthy brain function and behavior. Given the high prevalence of neurodevelopmental disorders, such as autism, identifying disruptors of developmental plasticity represents an essential step for developing strategies for prevention and intervention. Applying a novel computational approach that systematically assessed connections between 436 transcriptional signatures of disease and multiple signatures of neuroplasticity, we identified inflammation as a common pathological process central to a diverse set of diseases predicted to dysregulate plasticity signatures...
November 2016: ENeuro
https://www.readbyqxmd.com/read/28100736/methyl-cpg-binding-protein-mbd1-regulates-neuronal-lineage-commitment-through-maintaining-adult-neural-stem-cell-identity
#18
Emily M Jobe, Yu Gao, Brian E Eisinger, Janessa K Mladucky, Charles C Giuliani, Laurel E Kelnhofer, Xinyu Zhao
: Methyl-CpG-binding domain 1 (MBD1) belongs to a family of methyl-CpG-binding proteins that are epigenetic "readers" linking DNA methylation to transcriptional regulation. MBD1 is expressed in neural stem cells residing in the dentate gyrus of the adult hippocampus (aNSCs) and MBD1 deficiency leads to reduced neuronal differentiation, impaired neurogenesis, learning deficits, and autism-like behaviors in mice; however, the precise function of MBD1 in aNSCs remains unexplored. Here, we show that MBD1 is important for maintaining the integrity and stemness of NSCs, which is critical for their ability to generate neurons...
January 18, 2017: Journal of Neuroscience: the Official Journal of the Society for Neuroscience
https://www.readbyqxmd.com/read/28100473/delineating-the-phenotypic-spectrum-of-bainbridge-ropers-syndrome-12-new-patients-with-de-novo-heterozygous-loss-of-function-mutations-in-asxl3-and-review-of-published-literature
#19
M Balasubramanian, J Willoughby, A E Fry, A Weber, H V Firth, C Deshpande, J N Berg, K Chandler, K A Metcalfe, W Lam, D Pilz, S Tomkins
BACKGROUND: Bainbridge-Ropers syndrome (BRPS) is a recently described developmental disorder caused by de novo truncating mutations in the additional sex combs like 3 (ASXL3) gene. To date, there have been fewer than 10 reported patients. OBJECTIVES: Here, we delineate the BRPS phenotype further by describing a series of 12 previously unreported patients identified by the Deciphering Developmental Disorders study. METHODS: Trio-based exome sequencing was performed on all 12 patients included in this study, which found a de novo truncating mutation in ASXL3...
January 18, 2017: Journal of Medical Genetics
https://www.readbyqxmd.com/read/28099978/association-of-perinatal-risk-factors-with-autism-spectrum-disorder
#20
Darios Getahun, Michael J Fassett, Morgan R Peltier, Deborah A Wing, Anny H Xiang, Vicki Chiu, Steven J Jacobsen
Objective To examine the association between exposures to perinatal factors and autism spectrum disorders (ASD). Study Design A retrospective cohort study of ASD among children born in Kaiser Permanente Southern California hospitals between 1991 and 2009 (n = 594,638). Medical records were used to determine exposure to perinatal (antepartum and intrapartum) complications. ASD was diagnosed using DSM-IV criteria. Multivariable Cox regression was used to estimate hazard ratios (HRs). Result Children with ASD were more likely to be exposed to perinatal complications (HR = 1...
January 18, 2017: American Journal of Perinatology
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