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JOURNAL ARTICLE
Claudio Marcelo Hernández Mosqueira, Humberto Eugenio Castillo Quezada, Sandro Fernandes da Silva, Sebastian Peña Troncoso, Mauricio Adrián Cresp Barría, Jaime Cárcamo-Oyarzun, Cristian Martínez-Salazar, Alexis Caniuqueo Vargas, José Fernandes Filho
INTRODUCTION: currently, regular physical exercise is the best tool available to promote people's well-being and improve their health. OBJECTIVE: the objective of the study was to determine the level of physical condition and nutritional status, as well as the relationship between them, in elementary school students in the city of Chillán. METHODS: the study is of the descriptive, cross-sectional, relational type. A total of 2500 students participated...
October 29, 2020: Nutrición Hospitalaria: Organo Oficial de la Sociedad Española de Nutrición Parenteral y Enteral
#22
JOURNAL ARTICLE
Thierry Gagné, Josée Lapalme, Adrian E Ghenadenik, Jennifer L OLoughlin, Katherine Frohlich
BACKGROUND: To better understand whether tobacco control policies are associated with changes in secondhand smoke (SHS) exposure across socioeconomic groups, we monitored differences in socioeconomic inequalities in SHS exposure in households and private vehicles among youth and adults before, during and after adoption of Quebec's 2015 An Act to Bolster Tobacco Control . METHODS: Using data from the Canadian Community Health Survey, we examined the prevalence of daily exposure to SHS in households and private vehicles among youth (ages 12 to 17) and adults (ages 18+) across levels of household education and income (separately) in 2013/2014, 2015/2016 and 2017/2018...
October 28, 2020: Tobacco Control
#23
JOURNAL ARTICLE
Jeffrey Seow, Carl Graham, Blair Merrick, Sam Acors, Suzanne Pickering, Kathryn J A Steel, Oliver Hemmings, Aoife O'Byrne, Neophytos Kouphou, Rui Pedro Galao, Gilberto Betancor, Harry D Wilson, Adrian W Signell, Helena Winstone, Claire Kerridge, Isabella Huettner, Jose M Jimenez-Guardeño, Maria Jose Lista, Nigel Temperton, Luke B Snell, Karen Bisnauthsing, Amelia Moore, Adrian Green, Lauren Martinez, Brielle Stokes, Johanna Honey, Alba Izquierdo-Barras, Gill Arbane, Amita Patel, Mark Kia Ik Tan, Lorcan O'Connell, Geraldine O'Hara, Eithne MacMahon, Sam Douthwaite, Gaia Nebbia, Rahul Batra, Rocio Martinez-Nunez, Manu Shankar-Hari, Jonathan D Edgeworth, Stuart J D Neil, Michael H Malim, Katie J Doores
Antibody responses to SARS-CoV-2 can be detected in most infected individuals 10-15 d after the onset of COVID-19 symptoms. However, due to the recent emergence of SARS-CoV-2 in the human population, it is not known how long antibody responses will be maintained or whether they will provide protection from reinfection. Using sequential serum samples collected up to 94 d post onset of symptoms (POS) from 65 individuals with real-time quantitative PCR-confirmed SARS-CoV-2 infection, we show seroconversion (immunoglobulin (Ig)M, IgA, IgG) in >95% of cases and neutralizing antibody responses when sampled beyond 8 d POS...
December 2020: Nature Microbiology
#24
MULTICENTER STUDY
Jose-Manuel Ramos-Rincon, Verónica Buonaiuto, Michele Ricci, Jesica Martín-Carmona, Diana Paredes-Ruíz, María Calderón-Moreno, Manel Rubio-Rivas, José-Luis Beato-Pérez, Francisco Arnalich-Fernández, Daniel Monge-Monge, Juan-Antonio Vargas-Núñez, Gonzalo Acebes-Repiso, Manuel Mendez-Bailon, Isabel Perales-Fraile, Gema-María García-García, Pablo Guisado-Vasco, Alaaeldeen Abdelhady-Kishta, Maria-de-Los-Reyes Pascual-Pérez, Cristina Rodríguez-Fernández-Viagas, Adrián Montaño-Martínez, Antonio López-Ruiz, Maria-Jesus Gonzalez-Juarez, Cristina Pérez-García, José-Manuel Casas-Rojo, Ricardo Gómez-Huelgas
BACKGROUND: Advanced age is a well-known risk factor for poor prognosis in COVID-19. However, few studies have specifically focused on very old inpatients with COVID-19. This study aims to describe the clinical characteristics of very old inpatients with COVID-19 and identify risk factors for in-hospital mortality at admission. METHODS: We conducted a nationwide, multicenter, retrospective, observational study in patients ≥ 80 years hospitalized with COVID-19 in 150 Spanish hospitals (SEMI-COVID-19) Registry (March 1-May 29, 2020)...
February 25, 2021: Journals of Gerontology. Series A, Biological Sciences and Medical Sciences
#25
JOURNAL ARTICLE
José A de la Peña-Celaya, Jocelyn Aguilar-Luevano, Luisa Ma Alcivar-Cedeño, José L Álvarez-Vera, Irene Anaya-Cuellar, Erika Añorve-Hernández, Luara L Arana-Luna, Luis Arteaga-Ortíz, Pamela E Báez-Islas, Luisa I Banda-García, Ramón A Bates-Martín, Dafne Itzel Campa-Monroy, Mariela Cardiel-Silva, Ángel de Jesús Castillo-Salas, Xóchitl Cota-Rangel, Guillermo Díaz-Vargas, M Eugenia Espitia-Ríos, Patricia Estrada-Domínguez, Denisse Fermín-Caminero, Alinka García-Camacho, Carolina García-Castillo, Katheryn B Garzón-Velásquez, Carlos Gil-Rondero, Lidia V Guerra-Alarcón, Ana K Hernández-Colín, Eleazar Hernández-Ruiz, Areli E Hernández-Alcántara, Silvia A Hernández-Cervantes, Wilfrido Herrera-Olivares, Gregorio Ignacio-Ibarra, Sergio I Inclán-Alarcón, Faustino Leyto-Cruz, Juan P Macías-Flores, Andrea Martínez-de la Vega, Mario Alberto Martínez-Ramírez, Jorge Martínez-Coronel, Jesús Emanuel Medina-Coral, Lizeth Meza-Dávalos, Leire Montoya-Jiménez, Alba Morales-Hernández, Elizabeth Morales-López, Javier de Jesús Morales-Adrián, Maricruz Morales-de Azcué, Aldo Mújica-Martínez, Juan L Murillo-Cruz, Jéssica Nájera-Martínez, Iris Mabel Narváez-Sarmiento, Lorena Nava-Villegas, Marco A Nava-Alpide, Juan J Orellana Garibay, Ma Teresa Palafox-Zaldívar, Orlando G Palma-Moreno, Eugenia P Paredes-Lozano, Ma Luisa Pedraza-Colín, Juan M Pérez-Zúñiga, Alejandra B Pérez-Lizardi, Flavio Rojas-Castillejos, Eduardo Romero-Martínez, Hilda Romero-Rodelo, Josué Ruiz-Contreras, Azucena Saavedra-González, Erick Saucedo-Montes, Luis G Silva-Michel, Karina Silva-Vera, Óscar Teomitzi-Sánchez, Fredy Tepepa-Flores, Yanet Ventura-Enríquez, Atenas Villela-Peña, Shendel P Vilchis-González, Nidia Zapata-Canto, Pedro A Zárate-Rodríguez, Martha Alvarado-Ibarra
To identify this increasingly common pathology, known as multiple myeloma (MM), it is necessary to refer to the specific factors that characterize it; to this end, the classic criteria known as CRAB (hyperkalemia, renal failure, anemia, and lytic lesions) are available, in which renal failure is one of the most frequent complications. Recently, three indisputable biomarkers have been described for the diagnostic support for MM, which are: more than 10% of clonal plasma cells in bone marrow or, a biopsy that corroborates the presence of a plasmacytoma, light chain ratio ≥ 100 mg/dL and more than one focal lesion on magnetic resonance imaging...
2020: Gaceta Médica de México
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JOURNAL ARTICLE
Noelia Domínguez-Morueco, Luis Moreno-Merino, Daniel Molins-Delgado, M Silvia Díaz-Cruz, Òscar Aznar-Alemany, Ethel Eljarrat, Marinella Farré, Jerónimo López-Martínez, Miren López de Alda, Adrián Silva, Juan José Durán Valsero, Yolanda Valcárcel
This study aimed to evaluate the presence of ultraviolet filters (UV-Fs), benzotriazoles, pyrethroids and per- and polyfluoroalkyl substances (PFASs) in freshwater and wastewater from the northern Antarctic Peninsula region. All water samples analyzed contained UV-Fs residues and high concentrations were detected in anthropogenic impacted sites (< LOD up to 1300 ng/L). Likewise, benzotriazoles were detected in all water samples (< LOQ-920 ng/L). Regarding suspended particulate matter, almost all UV-Fs and all benzotriazoles were measured at concentrations ranging from < LOQ to 33 µg/g dry weight...
October 24, 2020: Ambio
#27
JOURNAL ARTICLE
Adrián Mosquera Orgueira, José Ángel Díaz Arias, Miguel Cid López, Andrés Peleteiro Raíndo, Beatriz Antelo Rodríguez, Carlos Aliste Santos, Natalia Alonso Vence, Ángeles Bendaña López, Aitor Abuín Blanco, Laura Bao Pérez, Marta Sonia González Pérez, Manuel Mateo Pérez Encinas, Máximo Francisco Fraga Rodríguez, José Luis Bello López
BACKGROUND: Thirty to forty percent of patients with Diffuse Large B-cell Lymphoma (DLBCL) have an adverse clinical evolution. The increased understanding of DLBCL biology has shed light on the clinical evolution of this pathology, leading to the discovery of prognostic factors based on gene expression data, genomic rearrangements and mutational subgroups. Nevertheless, additional efforts are needed in order to enable survival predictions at the patient level. In this study we investigated new machine learning-based models of survival using transcriptomic and clinical data...
October 21, 2020: BMC Cancer
#28
JOURNAL ARTICLE
Jesús Maldonado, Ana Belén González-Guerrero, Adrián Fernández-Gavela, Juan José González-López, Laura M Lechuga
Infections by multidrug-resistant bacteria are becoming a major healthcare emergence with millions of reported cases every year and an increasing incidence of deaths. An advanced diagnostic platform able to directly detect and identify antimicrobial resistance in a faster way than conventional techniques could help in the adoption of early and accurate therapeutic interventions, limiting the actual negative impact on patient outcomes. With this objective, we have developed a new biosensor methodology using an ultrasensitive nanophotonic bimodal waveguide interferometer (BiMW), which allows a rapid and direct detection, without amplification, of two prevalent and clinically relevant Gram-negative antimicrobial resistance encoding sequences: the extended-spectrum betalactamase-encoding gene blaCTX-M-15 and the carbapenemase-encoding gene blaNDM-5 We demonstrate the extreme sensitivity and specificity of our biosensor methodology for the detection of both gene sequences...
October 19, 2020: Diagnostics
#29
JOURNAL ARTICLE
Lucía Jiménez-Gonzalo, Rosa Romero-Moreno, María Del Sequeros Pedroso-Chaparro, José Adrián Fernandes-Pires, Samara Barrera-Caballero, Javier Olazarán, Andrés Losada-Baltar
OBJECTIVES: Behavioral problems in people with dementia are a source of depression and anxiety for caregivers, who experience high levels of sleep problems. The present study aims to explore the role of sleep problems on the relationship between behavioral problems associated with dementias - considering its different dimensions - and family caregivers' depressive and anxious symptoms. METHOD: 264 family caregivers participated in the study. Through face-to-face interviews, sociodemographic and health variables, caregivers' depressive and anxious symptoms were measured, as well as their sleep problems...
October 21, 2020: Behavioral Sleep Medicine
#30
JOURNAL ARTICLE
Adrián M Garza-Gangemi, Ricardo A Castillejos-Molina, Guillermo Gueglio, Ignacio P Tobia Gonzalez, Alberto M Jurado, Luis Meza-Montoya, Carlos H Scorticati, Walter Henriques-da-Costa, Juan Yandian, Luis Ubillos, Sidney Glina, Marcos Tobias-Machado, Oscar Rodríguez-Faba, Carlos Ameri, Alejandro Nolazco, Pablo Martinez, Gustavo Franco-Carvalhal, Ruben G Bengio, Leandro Cristian Arribillaga, Raúl Langenhin, Diego Muguruza, José G Campos-Salcedo, Edgar I Bravo-Castro, Pablo A Mingote, Nicolás Ginestar, Ana M Autran-Gomez, Raúl Langenhin, Roberto Puente, Ricardo Decia, Gustavo Cardoso-Guimarães, Raúl Langenhin, Joan Palou-Redorta, Diego Abreu-Clavijo, Stenio de-Cassio-Zequi, Francisco T Rodriguez-Covarrubias
BACKGROUND: The incidence of renal cell carcinoma (RCC) is increasing globally due to an aging population and widespread use of imaging studies. OBJECTIVE: The aim of this study was to describe the characteristics and perioperative outcomes of RCC surgery in very elderly patients (VEP), ≥ 75 years of age. METHODS: This is a retrospective comparative study of 3656 patients who underwent the treatment for RCC from 1990 to 2015 in 28 centers from eight Latin American countries...
May 7, 2020: Revista de Investigación Clínica; Organo del Hospital de Enfermedades de la Nutrición
#31
JOURNAL ARTICLE
José L Neira, Bruno Rizzuti, Ana Jiménez-Alesanco, Olga Abián, Adrián Velázquez-Campoy, Juan L Iovanna
Numerous carrier proteins intervene in protein transport from the cytoplasm to the nucleus in eukaryotic cells. One of those is importin α, with several human isoforms; among them, importin α3 (Impα3) features a particularly high flexibility. The protein NUPR1L is an intrinsically disordered protein (IDP), evolved as a paralogue of nuclear protein 1 (NUPR1), which is involved in chromatin remodeling and DNA repair. It is predicted that NUPR1L has a nuclear localization sequence (NLS) from residues Arg51 to Gln74, in order to allow for nuclear translocation...
October 8, 2020: International Journal of Molecular Sciences
#32
JOURNAL ARTICLE
Javier Milagro, Adrián Hernández-Vicente, David Hernando, José A Casajús, Nuria Garatachea, Raquel Bailón, Esther Pueyo
Under the hypothesis that sympathetic control of ventricular repolarization may change once the second ventilatory threshold (VT2) has been reached, a novel methodology for noninvasive VT2 estimation based on the analysis of the T wave from the electrocardiogram (ECG) is proposed, and potential underlying physiological mechanisms are suggested. 25 volunteers (33.4 ± 5.2 years) underwent an incremental power cycle ergometer test (25 W/minute). During the test, respiratory gas exchange and multi-lead ECG were acquired...
October 10, 2020: Scandinavian Journal of Medicine & Science in Sports
#33
JOURNAL ARTICLE
Fanny Joubert, Adrian Guerrero-Moreno, Darine Fakih, Elodie Reboussin, Claire Gaveriaux-Ruff, Maria Carmen Acosta, Juana Gallar, José Alain Sahel, Laurence Bodineau, Christophe Baudouin, William Rostène, Stéphane Mélik-Parsadaniantz, Annabelle Réaux-Le Goazigo
Corneal pain is considered to be a core symptom of ocular surface disruption and inflammation. The management of this debilitating condition is still a therapeutic challenge. Recent evidence supports a role of the opioid system in the management of corneal nociception. However, the functional involvement of the mu opioid receptor (MOR) underlying this analgesic effect is not known. We first investigated the expression of the MOR in corneal nerve fibers and trigeminal ganglion (TG) neurons in control mice and a mouse model of corneal inflammatory pain...
October 6, 2020: Biomedicine & Pharmacotherapy
#34
JOURNAL ARTICLE
Alejandro Mendoza-Alvarez, Adrián Muñoz-Barrera, Luis Alberto Rubio-Rodríguez, Itahisa Marcelino-Rodriguez, Almudena Corrales, Antonio Iñigo-Campos, Ariel Callero, Eva Perez-Rodriguez, Jose Carlos Garcia-Robaina, Rafaela González-Montelongo, Jose Miguel Lorenzo-Salazar, Carlos Flores
BACKGROUND: Hereditary angioedema is a rare genetic condition caused by C1 esterase inhibitor deficiency, dysfunction, or kinin cascade dysregulation, leading to an increased bradykinin plasma concentration. Hereditary angioedema is a poorly recognized clinical entity and is very often misdiagnosed as a histaminergic angioedema. Despite its genetic nature, first-line genetic screening is not integrated in routine diagnosis. Consequently, a delay in the diagnosis, and inaccurate or incomplete diagnosis and treatment of hereditary angioedema are common...
October 9, 2020: Journal of Medical Internet Research
#35
MULTICENTER STUDY
Julio García-Suárez, Javier de la Cruz, Ángel Cedillo, Pilar Llamas, Rafael Duarte, Víctor Jiménez-Yuste, José Ángel Hernández-Rivas, Rodrigo Gil-Manso, Mi Kwon, Pedro Sánchez-Godoy, Pilar Martínez-Barranco, Blanca Colás-Lahuerta, Pilar Herrera, Laurentino Benito-Parra, Adrián Alegre, Alberto Velasco, Arturo Matilla, María Concepción Aláez-Usón, Rafael Martos-Martínez, Carmen Martínez-Chamorro, Keina Susana-Quiroz, Juan Francisco Del Campo, Adolfo de la Fuente, Regina Herráez, Adriana Pascual, Elvira Gómez, Jaime Pérez-Oteyza, Elena Ruiz, Arancha Alonso, José González-Medina, Lucía Núñez Martín-Buitrago, Miguel Canales, Isabel González-Gascón, María Carmen Vicente-Ayuso, Susana Valenciano, María García Roa, Pablo Estival Monteliu, Javier López-Jiménez, Cristián Escolano Escobar, Javier Ortiz-Martín, José Luis Diez-Martin, Joaquín Martinez-Lopez
BACKGROUND: Patients with cancer have been shown to have a higher risk of clinical severity and mortality compared to non-cancer patients with COVID-19. Patients with hematologic malignancies typically are known to have higher levels of immunosuppression and may develop more severe respiratory viral infections than patients with solid tumors. Data on COVID-19 in patients with hematologic malignancies are limited. Here we characterize disease severity and mortality and evaluate potential prognostic factors for mortality...
October 8, 2020: Journal of Hematology & Oncology
#36
JOURNAL ARTICLE
Francisco Daniel Pérez-Cano, Adrián Luque-Luque, Juan José Jiménez-Delgado
BACKGROUND AND OBJECTIVE: the acquisition of microscopic images of human bones is a complex and expensive process. Moreover, the objective of obtaining a large data bank with microscopic images in order to carry out massive studies or to train automatic generation algorithms is not an option. Consequently, most of the current work focuses on the analysis of small regions captured by a microscope. The aim is the development of a tool to represent bone tissue at microscopic levels which is suitable for performing physical simulations, as well as for the diagnosis of various diseases...
September 28, 2020: Computer Methods and Programs in Biomedicine
#37
JOURNAL ARTICLE
Juan Pablo Arab, Melisa Dirchwolf, Mário Reis Álvares-da-Silva, Francisco Barrera, Carlos Benítez, Marlene Castellanos-Fernandez, Graciela Castro-Narro, Norberto Chavez-Tapia, Daniela Chiodi, Helma Cotrim, Kenneth Cusi, Claudia Pinto Marques Souza de Oliveira, Javier Díaz, Eduardo Fassio, Solange Gerona, Marcos Girala, Nelia Hernandez, Sebastián Marciano, Walter Masson, Nahum Méndez-Sánchez, Nathalie Leite, Adelina Lozano, Martín Padilla, Arturo Panduro, Raymundo Paraná, Edison Parise, Marlene Perez, Jaime Poniachik, Juan Carlos Restrepo, Andrés Ruf, Marcelo Silva, Martín Tagle, Monica Tapias, Kenia Torres, Eduardo Vilar-Gomez, José Eduardo Costa Gil, Adrian Gadano, Marco Arrese
Non-alcoholic fatty liver disease (NAFLD) currently represents an epidemic worldwide. NAFLD is the most frequently diagnosed chronic liver disease, affecting 20-30% of the general population. Furthermore, its prevalence is predicted to increase exponentially in the next decades, concomitantly with the global epidemic of obesity, type 2 diabetes mellitus (T2DM), and sedentary lifestyle. NAFLD is a clinical syndrome that encompasses a wide spectrum of associated diseases and hepatic complications such as hepatocellular carcinoma (HCC)...
2020: Annals of Hepatology
#38
Carl Froilan D Leochico, Adrian I Espiritu, Sharon D Ignacio, Jose Alvin P Mojica
Background: Despite being known abroad as a viable alternative to face-to-face consultation and therapy, telerehabilitation has not fully emerged in developing countries like the Philippines. In the midst of the coronavirus disease 2019 (COVID-19) pandemic, wherein social distancing disrupted the in-clinic delivery of rehabilitation services, Filipinos attempted to explore telerehabilitation. However, several hindrances were observed especially during the pre-implementation phase of telerehabilitation, necessitating a review of existing local evidences...
2020: Frontiers in Neurology
#39
JOURNAL ARTICLE
John Gregson, Gregg W Stone, Ori Ben-Yehuda, Björn Redfors, David E Kandzari, Marie-Claude Morice, Martin B Leon, Ioanna Kosmidou, Nicholas J Lembo, W Morris Brown, Dimitri Karmpaliotis, Adrian P Banning, Jose Pomar, Manel Sabaté, Charles A Simonton, Ovidiu Dressler, Arie Pieter Kappetein, Joseph F Sabik, Patrick W Serruys, Stuart J Pocock
BACKGROUND: Varying definitions of procedural myocardial infarction (PMI) are in widespread use. OBJECTIVES: This study sought to determine the rates and clinical relevance of PMI using different definitions in patients with left main coronary artery disease randomized to percutaneous coronary intervention (PCI) versus coronary artery bypass grafting (CABG) surgery in the EXCEL (Evaluation of XIENCE versus Coronary Artery Bypass Surgery for Effectiveness of Left Main Revascularization) trial...
October 6, 2020: Journal of the American College of Cardiology
#40
REVIEW
Adrián Matencio, Fabrizio Caldera, Claudio Cecone, José Manuel López-Nicolás, Francesco Trotta
There have been many reviews of the cyclic oligosaccharide cyclodextrin (CD) and CD-based materials used for drug delivery, but the capacity of CDs to complex different agents and their own intrinsic properties suggest they might also be considered for use as active drugs, not only as carriers. The aim of this review is to summarize the direct use of CDs as drugs, without using its complexing potential with other substances. The direct application of another oligosaccharide called cyclic nigerosyl-1,6-nigerose (CNN) is also described...
September 29, 2020: Pharmaceuticals
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