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https://www.readbyqxmd.com/read/29450671/short-term-treatment-with-metformin-reduces-hepatic-lipid-accumulation-but-induces-liver-inflammation-in-obese-mice
#1
Alexandre Abilio de Souza Teixeira, Camila O Souza, Luana A Biondo, Loreana Sanches Silveira, Edson A Lima, Helena A Batatinha, Adriane Pereira Araujo, Michele Joana Alves, Sandro Massao Hirabara, Rui Curi, José Cesar Rosa Neto
The study aimed to evaluate the metabolic and inflammatory effects of short-term treatments (10 days) with metformin (MET) on the NAFLD caused by a high-fat diet (HFD) in C57BL/6 mice. After the treatment, histological liver slices were obtained, hepatocytes and macrophages were extracted and cultured with phosphate buffered saline, LPS (2.5 µg/mL) and MET (1 µM) for 24 h. Cytokine levels were determined by ELISA. NAFLD caused by the HFD was partially reduced by MET. The lipid accumulation induced by the HFD was not associated with liver inflammation; however, MET seemed to promote pro-inflammatory effects in liver, since it increased hepatic concentration of IL-1β, TNF-α, IL-6, MCP-1 and IFN-γ...
February 15, 2018: Inflammopharmacology
https://www.readbyqxmd.com/read/29449044/emerging-pollutants-ii-international-caparica-conference-on-pollutant-toxic-ions-and-molecules-2nd-ptim-2017
#2
EDITORIAL
Carlos Lodeiro, José Luis Capelo, Elisabete Oliveira, Adrián Fernández-Lodeiro
No abstract text is available yet for this article.
February 10, 2018: Journal of Hazardous Materials
https://www.readbyqxmd.com/read/29423709/an-ascomycota-coculture-in-batch-bioreactor-is-better-than-polycultures-for-cellulase-production
#3
Christian Hernández, Adriane M F Milagres, Gerardo Vázquez-Marrufo, Karla María Muñoz-Páez, José Antonio García-Pérez, Enrique Alarcón
Efficient hydrolysis of holocellulose depends on a proper balance between cellulase (endoglucanase, exoglucanase, β-glucosidase) and xylanase activities. The present study aimed to induce the production of cellulases and xylanases using liquid cultures (one, two, three, and four fungal strains on the same bioreactor) of wild strains of Trichoderma harzianum, Aspergillus niger, and Fusarium oxysporum. The strains were identified by amplification and analysis of the ITS rDNA region and the obtained sequences were deposited in Genbank...
February 8, 2018: Folia Microbiologica
https://www.readbyqxmd.com/read/29399697/a-60-kda-prolactin-variant-secreted-by-cervical-cancer-cells-modulates-apoptosis-and-cytokine-production
#4
Adrián Ramírez De Arellano, Annie Riera Leal, Edgar I Lopez-Pulido, Luis Renee González-Lucano, José Macías Barragan, Susana Del Toro Arreola, Mariel García-Chagollan, Claudia A Palafox-Sánchez, José F Muñoz-Valle, Ana Laura Pereira-Suárez
Prolactin (PRL) is associated with different types of cancer, such as cervical cancer. Recombinant PRL has antiapoptotic effect on cervical cancer cells, and it can also induce cytokine production on macrophages. A 60 kDa variant of PRL is produced by cervical cancer cells. The aim of the present study was to evaluate this variant's bioactivity, to test its effect on cervical cancer cell apoptosis, and to assess its ability to induce cytokine production on THP-1 macrophages. First, 60 kDa PRL was isolated and used to stimulate Nb2 cells...
January 19, 2018: Oncology Reports
https://www.readbyqxmd.com/read/29397883/relation-of-the-brugada-phenocopy-to-hyperkalemia-from-the-international-registry-on-brugada-phenocopy
#5
Grace Xu, Byron H Gottschalk, Daniel D Anselm, David G Benditt, Ankit Maheshwari, Shiva Sreenivasan, Raed Abu Shama, Gregory Dendramis, Héctor Barajas-Martínez, José Manuel Rubio Campal, Sam G Aznaurov, Adrian Baranchuk
Brugada phenocopies (BrPs) are clinical entities that differ in etiology from true congenital Brugada syndrome but have identical electrocardiographic (ECG) patterns. Hyperkalemia is known to be one of the causes of BrP. The aim of this study was to determine the clinical characteristics and evolution of hyperkalemia-induced BrP. Data from 27 cases of hyperkalemia-induced BrP were collected from the International Registry at www.brugadaphenocopy.com. Data were extracted from publications. Of the 27 patients included in the analysis, 18 (67%) were male; mean age was 53 ± 15 years (range 31 to 89)...
December 29, 2017: American Journal of Cardiology
https://www.readbyqxmd.com/read/29395491/epistasis-analysis-of-metabolic-genes-polymorphisms-associated-with-ischemic-heart-disease-in-yucatan
#6
Igrid García-González, Roger Iván López-Díaz, José Reyes Canché-Pech, Alberto de Jesús Solís-Cárdenas, Jorge A Flores-Ocampo, Renán Mendoza-Alcocer, Luis Fernando Herrera-Sánchez, Marco Antonio Jiménez-Rico, Adrián Alejandro Ceballos-López, María E López-Novelo
OBJECTIVE: Epistasis is a type of genetic interaction that could explain much of the phenotypic variability of complex diseases. In this work, the effect of epistasis of metabolic genes and cardiovascular risk on the susceptibility to the development of ischemic heart disease in Yucatan was determined. METHODS: Case-control study in 79 Yucatecan patients with ischemic heart disease and 101 healthy controls matched by age and origin with cases. The polymorphisms -108CT, Q192R, L55M (paraoxonase 1; PON1), C677T, A1298C (methylenetetrahydrofolate reductase; MTHFR), and the presence/absence of the glutathione S-transferase T1 (GSTT1) gene were genotyped...
January 28, 2018: Clínica e Investigación en Arteriosclerosis
https://www.readbyqxmd.com/read/29370982/production-of-lutein-and-polyunsaturated-fatty-acids-by-the-acidophilic-eukaryotic-microalga-coccomyxa-onubensis-under-abiotic-stress-by-salt-or-ultraviolet-light
#7
Elisabeth Bermejo, María C Ruiz-Domínguez, María Cuaresma, Isabel Vaquero, Adrian Ramos-Merchante, José M Vega, Carlos Vílchez, Inés Garbayo
In this study, the effect of abiotic stress on the acidophilic eukaryotic microalga, Coccomyxa onubensis, was analyzed for the production of lutein and PUFAs (polyunsaturated fatty acids). It grows autotrophically at a pH of 2.5. It showed a growth rate of 0.30 d-1, and produced approximately 122.50 mg.L-1.d-1 biomass, containing lipids (300.39 mg g-1dw), lutein (5.30 mg g-1dw), and β-carotene (1.20 mg g-1dw). The fatty acid methyl ester (FAME) fraction was 89.70 mg g-1dw with abundant palmitic acid (28...
January 20, 2018: Journal of Bioscience and Bioengineering
https://www.readbyqxmd.com/read/29363534/natural-disease-course-of-crohn-s-disease-during-the-first-5-years-after-diagnosis-in-a-european-population-based-inception-cohort-an-epi-ibd-study
#8
Johan Burisch, Gediminas Kiudelis, Limas Kupcinskas, Hendrika Adriana Linda Kievit, Karina Winther Andersen, Vibeke Andersen, Riina Salupere, Natalia Pedersen, Jens Kjeldsen, Renata D'Incà, Daniela Valpiani, Doron Schwartz, Selwyn Odes, Jóngerð Olsen, Kári Rubek Nielsen, Zsuzsanna Vegh, Peter Laszlo Lakatos, Alina Toca, Svetlana Turcan, Konstantinos H Katsanos, Dimitrios K Christodoulou, Mathurin Fumery, Corinne Gower-Rousseau, Stefania Chetcuti Zammit, Pierre Ellul, Carl Eriksson, Jonas Halfvarson, Fernando Jose Magro, Dana Duricova, Martin Bortlik, Alberto Fernandez, Vicent Hernández, Sally Myers, Shaji Sebastian, Pia Oksanen, Pekka Collin, Adrian Goldis, Ravi Misra, Naila Arebi, Ioannis P Kaimakliotis, Inna Nikuina, Elena Belousova, Marko Brinar, Silvija Cukovic-Cavka, Ebbe Langholz, Pia Munkholm
OBJECTIVE: The Epi-IBD cohort is a prospective population-based inception cohort of unselected patients with inflammatory bowel disease from 29 European centres covering a background population of almost 10 million people. The aim of this study was to assess the 5-year outcome and disease course of patients with Crohn's disease (CD). DESIGN: Patients were followed up prospectively from the time of diagnosis, including collection of their clinical data, demographics, disease activity, medical therapy, surgery, cancers and deaths...
January 23, 2018: Gut
https://www.readbyqxmd.com/read/29360754/characterization-of-different-cable-ferrite-materials-to-reduce-the-electromagnetic-noise-in-the-2-150-khz-frequency-range
#9
Adrian Suarez, Jorge Victoria, Antonio Alcarria, Jose Torres, Pedro A Martinez, Julio Martos, Jesus Soret, Raimundo Garcia-Olcina, Steffen Muetsch
The gap of standardization for conducted and field coupled electromagnetic interferences (EMI) in the 2-150 kHz frequency range can lead to Electromagnetic Compatibility (EMC) problems. This is caused by power systems such as Pulse Width Modulation (PWM) controlled rectifiers, photovoltaic inverters or charging battery units in electric vehicles. This is a very important frequency spectral due to interferences generated in a wide range of devices and, specifically, communication problems in the new technologies and devices incorporated to the traditional grid to convert it into a Smart Grid...
January 23, 2018: Materials
https://www.readbyqxmd.com/read/29359837/a-cluster-of-donor-derived-cryptococcus-neoformans-infection-affecting-lung-liver-and-kidney-transplant-recipients-case-report-and-review-of-literature
#10
Jose F Camargo, Jacques Simkins, Denise C Schain, A Adrian Gonzalez, Maria L Alcaide, Shweta Anjan, Giselle Guerra, David Roth, Warren L Kupin, Adela Mattiazzi, Yaohong Tan, Clara Milikowski, Michele I Morris, Lilian M Abbo
Donor-derived infections (DDIs) are a very rare but potentially devastating complication of solid organ transplantation. Here we present a cluster of proven donor-derived cryptococcal infection in the kidney, liver and lung recipients from a single donor. Remarkably, the onset of illness in the kidney and liver recipients occurred more than 8-12 weeks after transplantation, which is beyond the incubation period previously reported for donor-derived cryptococcosis. DDI should always be considered in the differential diagnosis of transplant recipients admitted with febrile illness, even when presenting beyond the first month post transplant...
January 23, 2018: Transplant Infectious Disease: An Official Journal of the Transplantation Society
https://www.readbyqxmd.com/read/29353019/induction-by-innate-defence-regulator-peptide-1018-of-pro-angiogenic-molecules-and-endothelial-cell-migration-in-a-high-glucose-environment
#11
Paulina Marin-Luevano, Valentin Trujillo, Adrian Rodriguez-Carlos, Irma González-Curiel, Jose A Enciso-Moreno, Robert E W Hancock, Bruno Rivas-Santiago
Synthetic innate defence regulator (IDR) peptides such as IDR-1018 modulate immunity to promote key protective functions including chemotaxis, wound healing, and anti-infective activity, while suppressing pro-inflammatory responses to non-pathological levels. Here we demonstrated that IDR-1018 induced, by up to 75-fold, pro-angiogenic VEGF-165 in keratinocytes but suppressed this isoform in endothelial cells. It also induced early angiogenin and prolonged anti-inflammatory TGFβ expression on endothelial cells, while suppressing early pro-inflammatory IL-1β expression levels...
January 15, 2018: Peptides
https://www.readbyqxmd.com/read/29327362/p-wave%C3%A2-and-interatrial-block-new-predictor-for-atrial-high-rate-episodes-in-patients-with-cardiac-implantable-electronic-devices
#12
José M Rubio Campal, Juan Benezet-Mazuecos, José Antonio Iglesias Bravo, Pepa Sánchez Borque, Ángel Miracle Blanco, Juan José de la Vieja Alarcón, Jaime Martínez Mariscal, Adrian M Baranchuk, Jerónimo Farré Muncharaz
BACKGROUND: The presence of interatrial block (IAB) is associated with the development of atrial fibrillation (AF). The aim of this study was to determine whether P-wave duration and presence of IAB before the implantation of a cardiac implantable electronic device (CIED) are associated with the presence of atrial high rate episodes (AHRE), during long-term follow-up. METHODS: 380 patients (57% men; 75 ± 10 years) were included. IAB was defined according to the International Consensus Criteria...
January 12, 2018: Pacing and Clinical Electrophysiology: PACE
https://www.readbyqxmd.com/read/29319604/the-european-society-of-regional-anaesthesia-and-pain-therapy-american-society-of-regional-anesthesia-and-pain-medicine-recommendations-on-local-anesthetics-and-adjuvants-dosage-in-pediatric-regional-anesthesia
#13
Santhanam Suresh, Claude Ecoffey, Adrian Bosenberg, Per-Anne Lonnqvist, Gildasio S de Oliveira, Oscar de Leon Casasola, José de Andrés, Giorgio Ivani
BACKGROUND AND OBJECTIVES: Dosage of local anesthetics (LAs) used for regional anesthesia in children is not well determined. In order to evaluate and come to a consensus regarding some of these controversial topics, The European Society of Regional Anaesthesia and Pain Therapy (ESRA) and the American Society of Regional Anesthesia and Pain Medicine (ASRA) developed a Joint Committee Practice Advisory on Local Anesthetics and Adjuvants Dosage in Pediatric Regional Anesthesia. METHODS: Representatives from both ASRA and ESRA composed the joint committee practice advisory...
January 9, 2018: Regional Anesthesia and Pain Medicine
https://www.readbyqxmd.com/read/29318095/green-and-red-fluorescent-dyes-for-translational-applications-in-imaging-and-sensing-analytes-a-dual-color-flag
#14
REVIEW
Elisabete Oliveira, Emilia Bértolo, Cristina Núñez, Viviane Pilla, Hugo M Santos, Javier Fernández-Lodeiro, Adrian Fernández-Lodeiro, Jamila Djafari, José Luis Capelo, Carlos Lodeiro
Red and green are two of the most-preferred colors from the entire chromatic spectrum, and red and green dyes are widely used in biochemistry, immunohistochemistry, immune-staining, and nanochemistry applications. Selective dyes with green and red excitable chromophores can be used in biological environments, such as tissues and cells, and can be irradiated with visible light without cell damage. This critical review, covering a period of five years, provides an overview of the most-relevant results on the use of red and green fluorescent dyes in the fields of bio-, chemo- and nanoscience...
January 2018: ChemistryOpen
https://www.readbyqxmd.com/read/29318092/green-and-red-fluorescent-dyes-for-translational-applications-in-imaging-and-sensing-analytes-a-dual-color-flag
#15
Elisabete Oliveira, Emilia Bértolo, Cristina Núñez, Viviane Pilla, Hugo M Santos, Javier Fernández-Lodeiro, Adrian Fernández-Lodeiro, Jamila Djafari, José Luis Capelo, Carlos Lodeiro
Invited for this month's cover picture is the BIOSCOPE group of Professors Carlos Lodeiro and José Luis Capelo at the REQUIMTE/UCIBIO-LAQv-FCT University NOVA of Lisbon (Portugal), and their collaborators. The cover picture is devoted to Translational Research, and shows the Portuguese Flag represented by the interaction between cells and Janus gold/silver nanoparticles functionalized with rhodamine (red) and Fluorescein (green) dyes as tools for biomedical translational research. Read the full text of their Review at 10...
January 2018: ChemistryOpen
https://www.readbyqxmd.com/read/29314762/opportunistic-infections-in-patients-with-idiopathic-inflammatory-myopathies
#16
Ada Redondo-Benito, Adrian Curran, Ana Villar-Gomez, Ernesto Trallero-Araguas, Andreu Fernández-Codina, Iago Pinal-Fernandez, Jose Ángel Rodrigo-Pendás, Albert Selva-O'Callaghan
AIM: To describe the prevalence, clinical characteristics and risk factors of opportunistic infection (OI) in a cohort of patients with inflammatory myopathies, and compare mortality rates between those with and without OIs. METHODS: In total, 204 patients from our myositis cohort were reviewed to identify patients who had experienced an OI during the period 1986-2014. The patients' clinical characteristics, treatments received, and outcomes were systematically recorded...
January 5, 2018: International Journal of Rheumatic Diseases
https://www.readbyqxmd.com/read/29288053/the-histidine-phosphocarrier-protein-hpr-binds-to-the-highly-thermostable-regulator-of-sigma-d-protein-rsd-and-its-isolated-helical-fragments
#17
José L Neira, Felipe Hornos, Concetta Cozza, Ana Cámara-Artigas, Olga Abián, Adrián Velázquez-Campoy
The phosphotransferase system (PTS) controls the preferential use of sugars in bacteria and it is also involved in other processes, such as chemotaxis. It is formed by a protein cascade in which the first two proteins are general (namely, EI and HPr) and the others are sugar-specific permeases. The Rsd protein binds specifically to the RNA polymerase (RNAP) σ70 factor. We first characterized the conformational stability of Escherichia coli Rsd. And second, we delineated the binding regions of Streptomyces coelicolor, HPrsc, and E...
December 26, 2017: Archives of Biochemistry and Biophysics
https://www.readbyqxmd.com/read/29286293/pinnatifidenyne-derived-ethynyl-oxirane-acetogenins-from-laurencia-viridis
#18
Adrián Morales-Amador, Caterina R de Vera, Olivia Márquez-Fernández, Antonio Hernández Daranas, José M Padrón, José J Fernández, María L Souto, Manuel Norte
Red algae of Laurencia continue to provide wide structural diversity and complexity of halogenated C15 acetogenin medium-ring ethers. Here, we described the isolation of three new C15 acetogenins (3-5), and one truncated derivative (6) from Laurencia viridis collected on the Canary Islands. These compounds are interesting variations on the pinnatifidenyne structure that included the first examples of ethynyl oxirane derivatives (3-4). The structures were elucidated by extensive study of NMR (Nuclear Magnetic Resonance) data, J-based configuration analysis and DFT (Density Functional Theory) calculations...
December 29, 2017: Marine Drugs
https://www.readbyqxmd.com/read/29279235/attitudes-toward-working-conditions-are-european-union-workers-satisfied-with-their-working-hours-and-work-life-balance
#19
Nuria Matilla-Santander, Cristina Lidón-Moyano, Adrián González-Marrón, Kailey Bunch, Juan Carlos Martín-Sánchez, José M Martínez-Sánchez
OBJECTIVE: To describe the satisfaction with working hours and satisfaction with work-life balance and their association in the European Union (EU-28). METHOD: This is a cross-sectional study based on data from the Flash Eurobarometer 398 among workers of the EU-28 from 2014 (n=13,683). We calculated percentages and their 95% confidence intervals (95%CI). We also applied a multi-level generalised linear model using the Poisson family, to calculate the adjusted prevalence ratios (aPR) of satisfaction with work-life balance based on working hours...
December 23, 2017: Gaceta Sanitaria
https://www.readbyqxmd.com/read/29261736/randomized-clinical-trial-to-evaluate-the-effect-of-fecal-microbiota-transplant-for-initial-clostridium-difficile-infection-in-intestinal-microbiome
#20
RANDOMIZED CONTROLLED TRIAL
Adrián Camacho-Ortiz, Eva María Gutiérrez-Delgado, Jose F Garcia-Mazcorro, Soraya Mendoza-Olazarán, Adrián Martínez-Meléndez, Laura Palau-Davila, Simon D Baines, Héctor Maldonado-Garza, Elvira Garza-González
OBJECTIVE: The aim of this study was to evaluate the impact of fecal donor-unrelated donor mix (FMT-FURM) transplantation as first-line therapy for C. difficile infection (CDI) in intestinal microbiome. METHODS: We designed an open, two-arm pilot study with oral vancomycin (250mg every 6 h for 10-14 days) or FMT-FURM as treatments for the first CDI episode in hospitalized adult patients in Hospital Universitario "Dr. Jose Eleuterio Gonzalez". Patients were randomized by a closed envelope method in a 1: 1 ratio to either oral vancomycin or FMT-FURM...
2017: PloS One
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