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JOURNAL ARTICLE
Sonia Torres-Riera, Adrià Arboix, Olga Parra, Luís García-Erolesa, María-José Sánchez-López
INTRODUCTION: There are limited data on the outcome of acute ischemic stroke oldest old women. We assessed clinical risk factors for in-hospital mortality in women aged 85 years or more with acute ischemic stroke. METHODS: This single-center retrospective cohort study included 506 women aged ≥ 85 years collected from a total of 4,600 patients with acute cerebral infarction registered in an ongoing 24-year hospital stroke database. The identification of clinical risk factors for in-hospital mortality was the primary endpoint of the study...
January 29, 2024: Cerebrovascular Diseases
#2
JOURNAL ARTICLE
İbrahim Sönmez, Héctor Martínez Riveros, Cinta Folch, Clara Suñer, Yesika Díaz, Lucía Alonso, Cristina Agusti, Adrià Mendoza, Eloy José Tarín-Vicente, Xènia Oller, Andrea Alemany, Àngel Rivero, Eva Orviz, Ana Silva-Klug, Oriol Mitjà, Jordi Casabona
OBJECTIVES: Recent outbreaks of the mpox (monkeypox) virus have been detected in dense sexual networks of gay and bisexual men who have sex with men (GBMSM). The objective of this study is to describe and compare the epidemiological and behavioural characteristics, as well as the sexual networks, of GBMSM diagnosed with mild mpox in Spain. METHODS: A prospective case-control study was conducted in Spain from July 2022 to February 2023. The study targeted a key population of GBMSM aged 18 years or older...
September 13, 2023: Sexually Transmitted Infections
#3
JOURNAL ARTICLE
Irene Diéguez Hernández-Vaquero, Anna Domènech Tàrrega, Adrià Costa-Roig, Miguel Couselo Jerez, Juan José Vila Carbó
INTRODUCTION: Portal vein thrombosis (PVT) is the most frequent cause of portal hypertension in paediatric population. Baveno VI Consensus considers endoscopic variceal ligation as the second therapeutic option after meso-Rex bypass (surgical shunt). AIM: Analyse the diagnostic profitability of non-invasive scales in order to predict the risk of oesophageal varices (OV) in children with PVT. MATERIAL AND METHODS: Descriptive retrospective study where every upper gastrointestinal endoscopy (UGE) carried on patients <15 years old with non-cirrhotic PVT were included...
August 9, 2023: Gastroenterología y Hepatología
#4
JOURNAL ARTICLE
Óscar Gasulla, Maria J Ledesma-Carbayo, Luisa N Borrell, Jordi Fortuny-Profitós, Ferran A Mazaira-Font, Jose María Barbero Allende, David Alonso-Menchén, Josep García-Bennett, Belen Del Río-Carrrero, Hector Jofré-Grimaldo, Aleix Seguí, Jorge Monserrat, Miguel Teixidó-Román, Adrià Torrent, Miguel Ángel Ortega, Melchor Álvarez-Mon, Angel Asúnsolo
Introduction: This study aimed to develop an individualized artificial intelligence model to help radiologists assess the severity of COVID-19's effects on patients' lung health. Methods: Data was collected from medical records of 1103 patients diagnosed with COVID-19 using RT- qPCR between March and June 2020, in Hospital Madrid-Group (HM-Group, Spain). By using Convolutional Neural Networks, we determine the effects of COVID-19 in terms of lung area, opacities, and pulmonary air density. We then combine these variables with age and sex in a regression model to assess the severity of these conditions with respect to fatality risk (death or ICU)...
2023: Frontiers in Bioengineering and Biotechnology
#5
JOURNAL ARTICLE
Jordi Sarto, Raquel Ruiz-García, Núria Guillén, Óscar Ramos-Campoy, Neus Falgàs, Diana Esteller, José Contador, Guadalupe Fernández, Yolanda González, Adrià Tort-Merino, Jordi Juncà-Parella, Bea Bosch, Sergi Borrego-Écija, Laura Molina-Porcel, Magda Castellví, Miguel Vergara, Anna Antonell, Josep María Augé, Laura Naranjo, Raquel Sanchez-Valle, Albert Lladó, Mircea Balasa
BACKGROUND AND OBJECTIVES: Blood-based biomarkers have emerged as minimally-invasive options for evaluating cognitive impairment. Most studies to date have assessed them in research cohorts, limiting their generalization to everyday clinical practice. We evaluated their diagnostic performance and clinical applicability in a prospective, real-world, memory clinic cohort. METHODS: All patients referred with suspected cognitive impairment between July 2019 and June 2021, were prospectively invited to participate...
November 30, 2022: Neurology
#6
JOURNAL ARTICLE
Adrià Bermudo-Gallaguet, Mar Ariza, Rosalia Dacosta-Aguayo, Daniela Agudelo, Neus Camins-Vila, Maria Boldó, Òscar Carrera, Sandra Vidal, Blai Ferrer-Uris, Albert Busquets, Marc Via, Guillem Pera, Cynthia Cáceres, Meritxell Gomis, Alberto García-Molina, José María Tormos, Ana Arrabé, Gustavo Diez, Maria José Durà Mata, Pere Torán-Monserrat, Juan José Soriano-Raya, Sira Domènech, Alexandre Perera-Lluna, Kirk I Erickson, Maria Mataró
Background: Post-stroke cognitive and emotional complications are frequent in the chronic stages of stroke and have important implications for the functionality and quality of life of those affected and their caregivers. Strategies such as mindfulness meditation, physical exercise (PE), or computerized cognitive training (CCT) may benefit stroke patients by impacting neuroplasticity and brain health. Materials and methods: One hundred and forty-one chronic stroke patients are randomly allocated to receive mindfulness-based stress reduction + CCT ( n = 47), multicomponent PE program + CCT ( n = 47), or CCT alone ( n = 47)...
2022: Frontiers in Aging Neuroscience
#7
JOURNAL ARTICLE
Adrià Costa-Roig, José Antonio March-Villalba, Irene Diéguez, Ignacio Miró, Lucía Rodríguez, María Ángeles Conca, Alba Polo, Agustín Serrano
OBJECTIVE: To analyse the clinical evolution, the therapeutic strategies and the characteristics of the patients presenting enuresis attended at our outpatient clinic. MATERIAL AND METHODS: Retrospective study of patients <14 years old(yo) diagnosed of enuresis attended at our outpatient clinic (2011-2019) and completed their follow-up (remission or aged 15). Urotherapy was offered to all patients as initial management. The therapeutic strategies were classified as: first line (desmopressin or clock alarm), second line (desmo-pressin+alarm) and third line(anticholinergics)...
May 28, 2022: Archivos Españoles de Urología
#8
JOURNAL ARTICLE
Clara Grilo, Beatriz C Afonso, Filipe Afonso, Marta Alexandre, Sara Aliácar, Ana Almeida, Ivan Prego Alonso, Francisco Álvares, Paulo Alves, Paulo Célio Alves, Pedro Alves, Anabela Amado, Vitor Amendoeira, Francisco Amorim, Guilherme da Silva Aparício, Ricardo Araújo, Fernando Ascensão, Margarida Augusto, Victor Bandeira, A Márcia Barbosa, Soraia Barbosa, Sérgio Barbosa, Silvia Barreiro, Paulo Barros, Tânia Barros, Filomena Barros, Mafalda Basto, Joana Bernardino, Sara Bicho, Luis Eduardo Biedma, Marta Borges, Luis Braz, José Carlos Brito, Tiago Brito, João Alexandre Cabral, Javier Calzada, Cláudia Camarinha, Mafalda Carapuço, Paulo Cardoso, Mário Carmo, Carlos Carrapato, Maílis da Silva Carrilho, Diogo Filipe T C S Carvalho, Filipe Carvalho, João Carvalho, Diana Castro, Guilherme Castro, Joana Castro, Luis Roma Castro, Filipe Xavier Catry, Ana M Cerveira, André Cid, Rafael Clarke, Conceição Conde, José Conde, Jorge Costa, Mafalda Costa, Pedro Costa, Cristina Costa, André Pedro do Couto, João Craveiro, Marta Dias, Sofia Dias, Beatriz Duarte, Virginia Duro, Cláudia Encarnação, Sofia Eufrázio, António Fael, João Salvador Falé, Sandra Faria, Carlos Fernandes, Margarida Fernandes, Gonçalo Ferrão da Costa, Clara Ferreira, Diogo F Ferreira, Eduardo Ferreira, Joaquim Pedro Ferreira, João Ferreira, Diana Ferreira, Carlos Fonseca, Inês Fontes, Ricardo Fragoso, Claudia Franco, Tamira Freitas, Sofia I Gabriel, Rory Gibb, Patricia Gil, Carla Patricia Jorge Gomes, Pedro Horta, Pedro Gomes, Verónica Gomes, Filipa Grilo, Américo Guedes, Filipa Guilherme, Iván Gutiérrez, Henry Harper, José M Herrera, Dário Hipólito, Samuel Infante, José Jesus, Kate E Jones, Marina I Laborde, Luís Lamas de Oliveira, Inês Leitão, Rita Lemos, Cátia Lima, Paloma Linck, Hugo Lopes, Susana Lopes, Adrià López-Baucells, Armando Loureiro, Filipa Loureiro, Rui Lourenço, Sofia Lourenço, Paula Lucas, Ana Magalhães, Cristina Maldonado, Fabio Marcolin, Sara Marques, J Tiago Marques, Carina Marques, Paulo Marques, Pedro Caetano Marrecas, Frederico Martins, Raquel Martins, Miguel Mascarenhas, Vanessa A Mata, Ana Rita Mateus, Milene Matos, Denis Medinas, Tiago Mendes, Gabriel Mendes, Frederico Mestre, Catarina Milhinhas, António Mira, Rita I Monarca, Norberto Monteiro, Barbara Monteiro, Pedro Monterroso, Mónia Nakamura, Nuno Negrões, Eva K Nóbrega, Miguel Nóvoa, Manuel Nunes, Nuno Jardim Nunes, Flávio Oliveira, José Miguel Oliveira, Jorge M Palmeirim, João Pargana, Anabela Paula, Joana Paupério, Nuno M Pedroso, Guilherme Pereira, Pedro F Pereira, José Pereira, Maria João Ramos Pereira, Francisco Petrucci-Fonseca, Miguel Pimenta, Sara Pinto, Nuno Pinto, Rosa Pires, Ricardo Pita, Carlos Pontes, Marisa Quaresma, João Queirós, Luís Queirós, Ana Rainho, Maria da Graça Ramalhinho, Patrícia Ramalho, Helena Raposeira, Francisco Rasteiro, Hugo Rebelo, Frederico Tátá Regala, Dyana Reto, Sérgio Bruno Ribeiro, Helena Rio-Maior, Ricardo Rocha, Rita Gomes Rocha, Luísa Rodrigues, Jacinto Román, Sara Roque, Luís Miguel Rosalino, Inês T do Rosário, Mariana Rossa, Danilo Russo, Pedro Sá, Helena Sabino-Marques, Vânia Salgueiro, Helena Santos, Joana Santos, João P V Santos, Nuno Santos, Sara Santos, Carlos Pedro Santos, Margarida Santos-Reis, Ana Serronha, Pablo Sierra, Bruno Silva, Carla S G M Silva, Clara Silva, Diogo Silva, Luís P da Silva, Ricardo Silva, Carmen Silva, Flavio Manoel Rodrigues da Silva Júnior, Pedro Sousa, Diana Sousa-Guedes, Giulia Spadoni, Joaquim T Tapisso, Daniela Teixeira, Sérgio Teixeira, Nuno Teixeira, Rita T Torres, Paulo Travassos, Hélia Vale-Gonçalves, Nuno Cidraes-Vieira, Sophie von Merten, Maria da Luz Mathias
Mammals are threatened worldwide, with ca. 26% of all species being included in the IUCN threatened categories. This overall pattern is primarily associated to habitat loss or degradation, and human persecution for terrestrial mammals, and pollution, open net fishing, climate change and prey depletion for marine mammals. Mammals play a key role in maintaining ecosystems functionality and resilience, and therefore information on their distribution is crucial to delineate and support conservation actions. MAMMALS IN PORTUGAL is a publicly available data set compiling unpublished geo-referenced occurrence records of 92 terrestrial, volant, and marine mammals in mainland Portugal and archipelagos of Azores and Madeira that includes 107,852 data entries between 1873 and 2021 (72% of the data occurring in 2000 and 2021)...
February 7, 2022: Ecology
#9
JOURNAL ARTICLE
José Contador, Nuria Guillén, Adrià Tort-Merino, Mircea Balasa, Neus Falgàs Martínez, Jaume Olives, Magdalena Castellví, Jordi Juncà-Parella, Sergi Borrego-Écija, Beatriz Bosch-Capdevila, Guadalupe Fernández-Villullas, Oscar Ramos-Campoy, Anna Antonell, Raquel Sanchez-Valle, Albert Lladó
BACKGROUND: The ongoing COVID-19 pandemic and related care policies have affected dementia patients. The characteristics of early-onset dementia (EOD, <65 years) patients in 2020 may provide insights on how to rearrange the provision of care. METHOD: We retrospectively reviewed, from 2016 to 2020, the demographic and clinical data of the new referrals at our EOD clinic (Hospital Clínic Barcelona). We used Fisher's Exact test and Mann-Whitney U test in R4.0.2 (https://www...
December 2021: Alzheimer's & Dementia: the Journal of the Alzheimer's Association
#10
JOURNAL ARTICLE
Verónica Prado, María Hernández-Tejero, Marcus M Mücke, Francesc Marco, Wenyi Gu, Alex Amoros, David Toapanta, Enric Reverter, Carlos de la Peña-Ramirez, Laura Altenpeter, Octavi Bassegoda, Gabriel Mezzano, Fátima Aziz, Adria Juanola, Sergio Rodríguez-Tajes, Vanessa Chamorro, David López, Marta Reyes, Michael Hogardt, Volkhard A J Kempf, Philip G Ferstl, Stefan Zeuzem, José Antonio Martínez, Jordi Vila, Vicente Arroyo, Jonel Trebicka, Javier Fernandez
BACKGROUND & AIMS: It remains unclear whether rectal colonization with multidrug-resistant organisms (MDROs) is prevalent and predisposes to infections by the same pathogens in patients with cirrhosis. METHODS: Two series of critically ill patients were evaluated. In the Barcelona cohort, 486 consecutive patients were prospectively evaluated, 129 with and 357 without cirrhosis (2015-2016). Rectal swabs were performed at admission and weekly thereafter (until intensive care unit [ICU] discharge) to detect MDRO colonization...
May 2022: Journal of Hepatology
#11
JOURNAL ARTICLE
José Contador, Agnès Pérez-Millan, Nuria Guillen, Adrià Tort-Merino, Mircea Balasa, Neus Falgàs, Jaume Olives, Magdalena Castellví, Sergi Borrego-Écija, Beatriz Bosch, Guadalupe Fernández-Villullas, Oscar Ramos-Campoy, Anna Antonell, Nuria Bargalló, Raquel Sanchez-Valle, Roser Sala-Llonch, Albert Lladó
BACKGROUND: MRI atrophy predicts cognitive status in AD. However, this relationship has not been investigated in early-onset AD (EOAD, < 65 years) patients with a biomarker-based diagnosis. METHODS: Forty eight EOAD (MMSE ≥ 15; A + T + N +) and forty two age-matched healthy controls (HC; A - T - N -) from a prospective cohort underwent full neuropsychological assessment, 3T-MRI scan and lumbar puncture at baseline. Participants repeated the cognitive assessment annually...
October 19, 2021: Journal of Neurology
#12
JOURNAL ARTICLE
José Contador, Agnès Pérez-Millán, Adrià Tort-Merino, Mircea Balasa, Neus Falgàs, Jaume Olives, Magdalena Castellví, Sergi Borrego-Écija, Beatriz Bosch, Guadalupe Fernández-Villullas, Oscar Ramos-Campoy, Anna Antonell, Nuria Bargalló, Raquel Sanchez-Valle, Roser Sala-Llonch, Albert Lladó
There is evidence longitudinal atrophy in posterior brain areas in early-onset Alzheimer's disease (EOAD; aged < 65 years), but no studies have been conducted in an EOAD cohort with fluid biomarkers characterization. We used 3T-MRI and Freesurfer 6.0 to investigate cortical and subcortical gray matter loss at two years in 12 EOAD patients (A + T + N + ) compared to 19 controls (A-T-N-) from the Hospital Clínic Barcelona cohort. We explored group differences in atrophy patterns and we correlated atrophy and baseline CSF-biomarkers levels in EOAD...
August 25, 2021: NeuroImage: Clinical
#13
Juliette Coignard, Michael Lush, Jonathan Beesley, Tracy A O'Mara, Joe Dennis, Jonathan P Tyrer, Daniel R Barnes, Lesley McGuffog, Goska Leslie, Manjeet K Bolla, Muriel A Adank, Simona Agata, Thomas Ahearn, Kristiina Aittomäki, Irene L Andrulis, Hoda Anton-Culver, Volker Arndt, Norbert Arnold, Kristan J Aronson, Banu K Arun, Annelie Augustinsson, Jacopo Azzollini, Daniel Barrowdale, Caroline Baynes, Heko Becher, Marina Bermisheva, Leslie Bernstein, Katarzyna Białkowska, Carl Blomqvist, Stig E Bojesen, Bernardo Bonanni, Ake Borg, Hiltrud Brauch, Hermann Brenner, Barbara Burwinkel, Saundra S Buys, Trinidad Caldés, Maria A Caligo, Daniele Campa, Brian D Carter, Jose E Castelao, Jenny Chang-Claude, Stephen J Chanock, Wendy K Chung, Kathleen B M Claes, Christine L Clarke, J Margriet Collée, Don M Conroy, Kamila Czene, Mary B Daly, Peter Devilee, Orland Diez, Yuan Chun Ding, Susan M Domchek, Thilo Dörk, Isabel Dos-Santos-Silva, Alison M Dunning, Miriam Dwek, Diana M Eccles, A Heather Eliassen, Christoph Engel, Mikael Eriksson, D Gareth Evans, Peter A Fasching, Henrik Flyger, Florentia Fostira, Eitan Friedman, Lin Fritschi, Debra Frost, Manuela Gago-Dominguez, Susan M Gapstur, Judy Garber, Vanesa Garcia-Barberan, Montserrat García-Closas, José A García-Sáenz, Mia M Gaudet, Simon A Gayther, Andrea Gehrig, Vassilios Georgoulias, Graham G Giles, Andrew K Godwin, Mark S Goldberg, David E Goldgar, Anna González-Neira, Mark H Greene, Pascal Guénel, Lothar Haeberle, Eric Hahnen, Christopher A Haiman, Niclas Håkansson, Per Hall, Ute Hamann, Patricia A Harrington, Steven N Hart, Wei He, Frans B L Hogervorst, Antoinette Hollestelle, John L Hopper, Darling J Horcasitas, Peter J Hulick, David J Hunter, Evgeny N Imyanitov, Agnes Jager, Anna Jakubowska, Paul A James, Uffe Birk Jensen, Esther M John, Michael E Jones, Rudolf Kaaks, Pooja Middha Kapoor, Beth Y Karlan, Renske Keeman, Elza Khusnutdinova, Johanna I Kiiski, Yon-Dschun Ko, Veli-Matti Kosma, Peter Kraft, Allison W Kurian, Yael Laitman, Diether Lambrechts, Loic Le Marchand, Jenny Lester, Fabienne Lesueur, Tricia Lindstrom, Adria Lopez-Fernández, Jennifer T Loud, Craig Luccarini, Arto Mannermaa, Siranoush Manoukian, Sara Margolin, John W M Martens, Noura Mebirouk, Alfons Meindl, Austin Miller, Roger L Milne, Marco Montagna, Katherine L Nathanson, Susan L Neuhausen, Heli Nevanlinna, Finn C Nielsen, Katie M O'Brien, Olufunmilayo I Olopade, Janet E Olson, Håkan Olsson, Ana Osorio, Laura Ottini, Tjoung-Won Park-Simon, Michael T Parsons, Inge Sokilde Pedersen, Beth Peshkin, Paolo Peterlongo, Julian Peto, Paul D P Pharoah, Kelly-Anne Phillips, Eric C Polley, Bruce Poppe, Nadege Presneau, Miquel Angel Pujana, Kevin Punie, Paolo Radice, Johanna Rantala, Muhammad U Rashid, Gad Rennert, Hedy S Rennert, Mark Robson, Atocha Romero, Maria Rossing, Emmanouil Saloustros, Dale P Sandler, Regina Santella, Maren T Scheuner, Marjanka K Schmidt, Gunnar Schmidt, Christopher Scott, Priyanka Sharma, Penny Soucy, Melissa C Southey, John J Spinelli, Zoe Steinsnyder, Jennifer Stone, Dominique Stoppa-Lyonnet, Anthony Swerdlow, Rulla M Tamimi, William J Tapper, Jack A Taylor, Mary Beth Terry, Alex Teulé, Darcy L Thull, Marc Tischkowitz, Amanda E Toland, Diana Torres, Alison H Trainer, Thérèse Truong, Nadine Tung, Celine M Vachon, Ana Vega, Joseph Vijai, Qin Wang, Barbara Wappenschmidt, Clarice R Weinberg, Jeffrey N Weitzel, Camilla Wendt, Alicja Wolk, Siddhartha Yadav, Xiaohong R Yang, Drakoulis Yannoukakos, Wei Zheng, Argyrios Ziogas, Kristin K Zorn, Sue K Park, Mads Thomassen, Kenneth Offit, Rita K Schmutzler, Fergus J Couch, Jacques Simard, Georgia Chenevix-Trench, Douglas F Easton, Nadine Andrieu, Antonis C Antoniou
A Correction to this paper has been published: https://doi.org/10.1038/s41467-021-23162-4.
May 14, 2021: Nature Communications
#14
JOURNAL ARTICLE
Antonio Julià, Sergio H Martínez-Mateu, Eugeni Domènech, Juan D Cañete, Carlos Ferrándiz, Jesús Tornero, Javier P Gisbert, Antonio Fernández-Nebro, Esteban Daudén, Manuel Barreiro-de Acosta, Carolina Pérez, Rubén Queiró, Francisco Javier López-Longo, José Luís Sánchez Carazo, Juan Luís Mendoza, Mercedes Alpéri, Carlos Montilla, José Javier Pérez Venegas, Fernando Muñoz, Santos Castañeda, Adrià Aterido, María López Lasanta, Sara Marsal
BACKGROUND/OBJECTIVES: Immune-mediated inflammatory diseases (IMIDs) are prevalent diseases. There is, however, a lack of understanding of the link between diet and IMIDs, how much dietary patterns vary between them and if there are food groups associated with a worsening of the disease. SUBJECTS/METHODS: To answer these questions we analyzed a nation-wide cohort of n = 11,308 patients from six prevalent IMIDs and 2050 healthy controls. We compared their weekly intake of the major food categories, and used a Mendelian randomization approach to determine which dietary changes are caused by disease...
April 23, 2021: European Journal of Clinical Nutrition
#15
JOURNAL ARTICLE
Frederico F Martins, Ángel Sánchez-González, Jose Lanuza, Haralampos N Miras, Xabier Lopez, Nuno A G Bandeira, Adrià Gil
Phosphoester hydrolysis is an important chemical step in DNA repair. One archetypal molecular model of phosphoesters is para-nitrophenylphosphate (pNPP). It has been shown previously that the presence of molecular metal oxide [Mo 7 O 24 ] 6- may catalyse the hydrolysis of pNPP through the partial decomposition of polyoxomolybdate framework resulting in a [(PO 4 ) 2 Mo 5 O 15 ] 6- product. Real-time monitoring of the catalytic system using electrospray ionisation mass spectrometry (ESI-MS) provided a glance into the species present in the reaction mixture and identification of potential catalytic candidates...
April 22, 2021: Chemistry: a European Journal
#16
JOURNAL ARTICLE
Adrià Tort-Merino, Natalia Valech, Matti Laine, Jaume Olives, María León, Mirian Ecay-Torres, Ainara Estanga, Pablo Martínez-Lage, Juan Fortea, José Luis Molinuevo, Raquel Sánchez-Valle, Antoni Rodriguez-Fornells, Lorena Rami
We studied a sample of cognitively unimpaired individuals, with and without subjective cognitive decline (SCD), in order to investigate accelerated long-term forgetting (ALF) and to explore the relationships between objective and subjective cognitive performance and cerebrospinal fluid (CSF) Alzheimer's disease (AD) biomarkers. Fifty-two individuals were included and SCD was quantified through the Subjective Cognitive Decline Questionnaire (SCD-Q), using its validated cutoff to classify subjects as Low SCD-Q (n=21) or High SCD-Q (n=31)...
March 31, 2021: International Journal of Geriatric Psychiatry
#17
JOURNAL ARTICLE
Sonia Mendoza-Grey, Jose Ramos-Muniz, Adria N Armbrister, Ana F Abraído-Lanza
Breast cancer is the most commonly diagnosed cancer among Latinas. Dominican women in particular have a higher lifetime risk of breast cancer than do other Latinas in the U.S. This study examines how gender, ethnic, and language concordance between providers and patients are associated with recent mammography screening for Latina immigrant women from the Dominican Republic. We conducted structured interviews, in Spanish, with 419 Dominican women aged 40 years or older living in New York City. Using bivariate analysis and logistic regressions, we tested whether patient-provider gender, ethnic, and language concordance was associated with recent mammography when controlling for demographic covariates, breast cancer screening knowledge, and self-rated health...
March 3, 2021: Journal of Immigrant and Minority Health
#18
MULTICENTER STUDY
Juliette Coignard, Michael Lush, Jonathan Beesley, Tracy A O'Mara, Joe Dennis, Jonathan P Tyrer, Daniel R Barnes, Lesley McGuffog, Goska Leslie, Manjeet K Bolla, Muriel A Adank, Simona Agata, Thomas Ahearn, Kristiina Aittomäki, Irene L Andrulis, Hoda Anton-Culver, Volker Arndt, Norbert Arnold, Kristan J Aronson, Banu K Arun, Annelie Augustinsson, Jacopo Azzollini, Daniel Barrowdale, Caroline Baynes, Heiko Becher, Marina Bermisheva, Leslie Bernstein, Katarzyna Białkowska, Carl Blomqvist, Stig E Bojesen, Bernardo Bonanni, Ake Borg, Hiltrud Brauch, Hermann Brenner, Barbara Burwinkel, Saundra S Buys, Trinidad Caldés, Maria A Caligo, Daniele Campa, Brian D Carter, Jose E Castelao, Jenny Chang-Claude, Stephen J Chanock, Wendy K Chung, Kathleen B M Claes, Christine L Clarke, J Margriet Collée, Don M Conroy, Kamila Czene, Mary B Daly, Peter Devilee, Orland Diez, Yuan Chun Ding, Susan M Domchek, Thilo Dörk, Isabel Dos-Santos-Silva, Alison M Dunning, Miriam Dwek, Diana M Eccles, A Heather Eliassen, Christoph Engel, Mikael Eriksson, D Gareth Evans, Peter A Fasching, Henrik Flyger, Florentia Fostira, Eitan Friedman, Lin Fritschi, Debra Frost, Manuela Gago-Dominguez, Susan M Gapstur, Judy Garber, Vanesa Garcia-Barberan, Montserrat García-Closas, José A García-Sáenz, Mia M Gaudet, Simon A Gayther, Andrea Gehrig, Vassilios Georgoulias, Graham G Giles, Andrew K Godwin, Mark S Goldberg, David E Goldgar, Anna González-Neira, Mark H Greene, Pascal Guénel, Lothar Haeberle, Eric Hahnen, Christopher A Haiman, Niclas Håkansson, Per Hall, Ute Hamann, Patricia A Harrington, Steven N Hart, Wei He, Frans B L Hogervorst, Antoinette Hollestelle, John L Hopper, Darling J Horcasitas, Peter J Hulick, David J Hunter, Evgeny N Imyanitov, Agnes Jager, Anna Jakubowska, Paul A James, Uffe Birk Jensen, Esther M John, Michael E Jones, Rudolf Kaaks, Pooja Middha Kapoor, Beth Y Karlan, Renske Keeman, Elza Khusnutdinova, Johanna I Kiiski, Yon-Dschun Ko, Veli-Matti Kosma, Peter Kraft, Allison W Kurian, Yael Laitman, Diether Lambrechts, Loic Le Marchand, Jenny Lester, Fabienne Lesueur, Tricia Lindstrom, Adria Lopez-Fernández, Jennifer T Loud, Craig Luccarini, Arto Mannermaa, Siranoush Manoukian, Sara Margolin, John W M Martens, Noura Mebirouk, Alfons Meindl, Austin Miller, Roger L Milne, Marco Montagna, Katherine L Nathanson, Susan L Neuhausen, Heli Nevanlinna, Finn C Nielsen, Katie M O'Brien, Olufunmilayo I Olopade, Janet E Olson, Håkan Olsson, Ana Osorio, Laura Ottini, Tjoung-Won Park-Simon, Michael T Parsons, Inge Sokilde Pedersen, Beth Peshkin, Paolo Peterlongo, Julian Peto, Paul D P Pharoah, Kelly-Anne Phillips, Eric C Polley, Bruce Poppe, Nadege Presneau, Miquel Angel Pujana, Kevin Punie, Paolo Radice, Johanna Rantala, Muhammad U Rashid, Gad Rennert, Hedy S Rennert, Mark Robson, Atocha Romero, Maria Rossing, Emmanouil Saloustros, Dale P Sandler, Regina Santella, Maren T Scheuner, Marjanka K Schmidt, Gunnar Schmidt, Christopher Scott, Priyanka Sharma, Penny Soucy, Melissa C Southey, John J Spinelli, Zoe Steinsnyder, Jennifer Stone, Dominique Stoppa-Lyonnet, Anthony Swerdlow, Rulla M Tamimi, William J Tapper, Jack A Taylor, Mary Beth Terry, Alex Teulé, Darcy L Thull, Marc Tischkowitz, Amanda E Toland, Diana Torres, Alison H Trainer, Thérèse Truong, Nadine Tung, Celine M Vachon, Ana Vega, Joseph Vijai, Qin Wang, Barbara Wappenschmidt, Clarice R Weinberg, Jeffrey N Weitzel, Camilla Wendt, Alicja Wolk, Siddhartha Yadav, Xiaohong R Yang, Drakoulis Yannoukakos, Wei Zheng, Argyrios Ziogas, Kristin K Zorn, Sue K Park, Mads Thomassen, Kenneth Offit, Rita K Schmutzler, Fergus J Couch, Jacques Simard, Georgia Chenevix-Trench, Douglas F Easton, Nadine Andrieu, Antonis C Antoniou
Breast cancer (BC) risk for BRCA1 and BRCA2 mutation carriers varies by genetic and familial factors. About 50 common variants have been shown to modify BC risk for mutation carriers. All but three, were identified in general population studies. Other mutation carrier-specific susceptibility variants may exist but studies of mutation carriers have so far been underpowered. We conduct a novel case-only genome-wide association study comparing genotype frequencies between 60,212 general population BC cases and 13,007 cases with BRCA1 or BRCA2 mutations...
February 17, 2021: Nature Communications
#19
REVIEW
Marta Ávalos-Moreno, Araceli López-Tejada, Jose L Blaya-Cánovas, Francisca E Cara-Lupiañez, Adrián González-González, Jose A Lorente, Pedro Sánchez-Rovira, Sergio Granados-Principal
Triple-negative breast cancer (TNBC) is the most aggressive type of breast cancer which presents a high rate of relapse, metastasis, and mortality. Nowadays, the absence of approved specific targeted therapies to eradicate TNBC remains one of the main challenges in clinical practice. Drug discovery is a long and costly process that can be dramatically improved by drug repurposing, which identifies new uses for existing drugs, both approved and investigational. Drug repositioning benefits from improvements in computational methods related to chemoinformatics, genomics, and systems biology...
October 29, 2020: Journal of Personalized Medicine
#20
JOURNAL ARTICLE
Sandra Morales, Adrián Colomer, José M Mossi, Rocío Del Amor, David Woldbye, Kristian Klemp, Michael Larsen, Valery Naranjo
BACKGROUND AND OBJECTIVE: Optical coherence tomography (OCT) is a useful technique to monitor retinal layer state both in humans and animal models. Automated OCT analysis in rats is of great relevance to study possible toxic effect of drugs and other treatments before human trials. In this paper, two different approaches to detect the most significant retinal layers in a rat OCT image are presented. METHODS: One approach is based on a combination of local horizontal intensity profiles along with a new proposed variant of watershed transformation and the other is built upon an encoder-decoder convolutional network architecture...
October 9, 2020: Computer Methods and Programs in Biomedicine
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