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https://www.readbyqxmd.com/read/29237008/pharmacokinetics-of-darunavir-cobicistat-and-etravirine-alone-and-co-administered-in-hiv-infected-patients
#1
José Moltó, Adrian Curran, Cristina Miranda, Elizabeth Challenger, José Ramón Santos, Esteban Ribera, Saye Khoo, Marta Valle, Bonaventura Clotet
Objectives: To determine the effect of etravirine on the pharmacokinetics of darunavir/cobicistat and vice versa. Safety and tolerability of this combination were also evaluated. Methods: Open-label, fixed-sequence trial in two cohorts of HIV-infected patients on therapy with darunavir/cobicistat 800/150 mg once daily (DRV cohort; n = 15) or etravirine 400 mg once daily (ETR cohort; n = 15). Etravirine or darunavir/cobicistat were added on days 1-14 and 1-7 in participants in the DRV or ETR cohort, respectively...
December 11, 2017: Journal of Antimicrobial Chemotherapy
https://www.readbyqxmd.com/read/29234463/xylan-extraction-from-pretreated-sugarcane-bagasse-using-alkaline-and-enzymatic-approaches
#2
Daniele Sporck, Felipe A M Reinoso, Jorge Rencoret, Ana Gutiérrez, José C Del Rio, André Ferraz, Adriane M F Milagres
Background: New biorefinery concepts are necessary to drive industrial use of lignocellulose biomass components. Xylan recovery before enzymatic hydrolysis of the glucan component is a way to add value to the hemicellulose fraction, which can be used in papermaking, pharmaceutical, and food industries. Hemicellulose removal can also facilitate subsequent cellulolytic glucan hydrolysis. Results: Sugarcane bagasse was pretreated with an alkaline-sulfite chemithermomechanical process to facilitate subsequent extraction of xylan by enzymatic or alkaline procedures...
2017: Biotechnology for Biofuels
https://www.readbyqxmd.com/read/29230230/comparative-performance-of-ground-vs-aerially-assessed-rgb-and-multispectral-indices-for-early-growth-evaluation-of-maize-performance-under-phosphorus-fertilization
#3
Adrian Gracia-Romero, Shawn C Kefauver, Omar Vergara-Díaz, Mainassara A Zaman-Allah, Boddupalli M Prasanna, Jill E Cairns, José L Araus
Low soil fertility is one of the factors most limiting agricultural production, with phosphorus deficiency being among the main factors, particularly in developing countries. To deal with such environmental constraints, remote sensing measurements can be used to rapidly assess crop performance and to phenotype a large number of plots in a rapid and cost-effective way. We evaluated the performance of a set of remote sensing indices derived from Red-Green-Blue (RGB) images and multispectral (visible and infrared) data as phenotypic traits and crop monitoring tools for early assessment of maize performance under phosphorus fertilization...
2017: Frontiers in Plant Science
https://www.readbyqxmd.com/read/29217433/hypertrophic-cardiomyopathy-linked-mutation-in-troponin-t-causes-myofibrillar-disarray-and-pro-arrhythmic-action-potential-changes-in-human-ipsc-cardiomyocytes
#4
Lili Wang, Kyungsoo Kim, Shan Parikh, Adrian Gabriel Cadar, Kevin R Bersell, Huan He, Jose R Pinto, Dmytro O Kryshtal, Bjorn C Knollmann
BACKGROUND: Mutations in cardiac troponin T (TnT) are linked to increased risk of ventricular arrhythmia and sudden death despite causing little to no cardiac hypertrophy. Studies in mice suggest that the hypertrophic cardiomyopathy (HCM)-associated TnT-I79N mutation increases myofilament Ca sensitivity and is arrhythmogenic, but whether findings from mice translate to human cardiomyocyte electrophysiology is not known. OBJECTIVES: To study the effects of the TnT-I79N mutation in human cardiomyocytes...
December 4, 2017: Journal of Molecular and Cellular Cardiology
https://www.readbyqxmd.com/read/29216482/enantiomeric-profiling-of-chiral-illicit-drugs-in-a-pan-european-study
#5
Erika Castrignanò, Zhugen Yang, Richard Bade, Jose A Baz-Lomba, Sara Castiglioni, Ana Causanilles, Adrian Covaci, Emma Gracia-Lor, Felix Hernandez, Juliet Kinyua, Ann-Kathrin McCall, Alexander L N van Nuijs, Christoph Ort, Benedek G Plósz, Pedram Ramin, Nikolaos I Rousis, Yeonsuk Ryu, Kevin V Thomas, Pim de Voogt, Ettore Zuccato, Barbara Kasprzyk-Hordern
The aim of this paper is to present the first study on spatial and temporal variation in the enantiomeric profile of chiral drugs in eight European cities. Wastewater-based epidemiology (WBE) and enantioselective analysis were combined to evaluate trends in illicit drug use in the context of their consumption vs direct disposal as well as their synthetic production routes. Spatial variations in amphetamine loads were observed with higher use in Northern European cities. Enantioselective analysis showed a general enrichment of amphetamine with the R-(-)-enantiomer in wastewater indicating its abuse...
December 1, 2017: Water Research
https://www.readbyqxmd.com/read/29206820/-general-practitioner-certification
#6
José Adrián Rojas-Dosal
La regulación de la profesión médica es un proceso antiguo en nuestro país. Desde los tiempos del virreinato existía el Real Tribunal del Protomedicato, que tenía como función examinar a los médicos, cirujanos y boticarios para ser autorizados a ejercer su profesión; con el tiempo, esta función se fue relegando en otras estructuras administrativas que se fueron modificando, pero que la mantuvieron en vigor.
November 2017: Gaceta Médica de México
https://www.readbyqxmd.com/read/29188296/association-of-cerebral-amyloid-%C3%AE-aggregation-with-cognitive-functioning-in-persons-without-dementia
#7
Willemijn J Jansen, Rik Ossenkoppele, Betty M Tijms, Anne M Fagan, Oskar Hansson, William E Klunk, Wiesje M van der Flier, Victor L Villemagne, Giovanni B Frisoni, Adam S Fleisher, Alberto Lleó, Mark A Mintun, Anders Wallin, Sebastiaan Engelborghs, Duk L Na, Gäel Chételat, José Luis Molinuevo, Susan M Landau, Niklas Mattsson, Johannes Kornhuber, Osama Sabri, Christopher C Rowe, Lucilla Parnetti, Julius Popp, Tormod Fladby, William J Jagust, Pauline Aalten, Dong Young Lee, Rik Vandenberghe, Catarina Resende de Oliveira, Elisabeth Kapaki, Lutz Froelich, Adrian Ivanoiu, Tomasz Gabryelewicz, Marcel M Verbeek, Páscual Sanchez-Juan, Helmut Hildebrandt, Vincent Camus, Marzena Zboch, David J Brooks, Alexander Drzezga, Juha O Rinne, Andrew Newberg, Alexandre de Mendonça, Marie Sarazin, Gil D Rabinovici, Karine Madsen, Milica G Kramberger, Agneta Nordberg, Vincent Mok, Barbara Mroczko, David A Wolk, Philipp T Meyer, Magda Tsolaki, Philip Scheltens, Frans R J Verhey, Pieter Jelle Visser, Dag Aarsland, Daniel Alcolea, Myriam Alexander, Ina S Almdahl, Steven E Arnold, Inês Baldeiras, Henryk Barthel, Bart N M van Berckel, Kaj Blennow, Mark A van Buchem, Enrica Cavedo, Kewei Chen, Elena Chipi, Ann D Cohen, Stefan Förster, Juan Fortea, Kristian S Frederiksen, Yvonne Freund-Levi, Olymbia Gkatzima, Mark Forrest Gordon, Timo Grimmer, Harald Hampel, Lucrezia Hausner, Sabine Hellwig, Sanna-Kaisa Herukka, Peter Johannsen, Aleksandra Klimkowicz-Mrowiec, Sebastian Köhler, Norman Koglin, Koen van Laere, Mony de Leon, Viviana Lisetti, Wolfgang Maier, Jan Marcusson, Olga Meulenbroek, Hanne M Møllergård, John C Morris, Arto Nordlund, Gerald P Novak, George P Paraskevas, Gayan Perera, Oliver Peters, Inez H G B Ramakers, Lorena Rami, Eloy Rodríguez-Rodríguez, Catherine M Roe, Uros Rot, Eckart Rüther, Isabel Santana, Johannes Schröder, Sang W Seo, Hilkka Sorininen, Luiza Spiru, Erik Stomrud, Hanne Struyfs, Charlotte E Teunissen, Stephanie J B Vos, Linda J C van Waalwijk van Doorn, Gunhild Waldemar, Åsa K Wallin, Jens Wiltfang, Henrik Zetterberg
Importance: Cerebral amyloid-β aggregation is an early event in Alzheimer disease (AD). Understanding the association between amyloid aggregation and cognitive manifestation in persons without dementia is important for a better understanding of the course of AD and for the design of prevention trials. Objective: To investigate whether amyloid-β aggregation is associated with cognitive functioning in persons without dementia. Design, Setting, and Participants: This cross-sectional study included 2908 participants with normal cognition and 4133 with mild cognitive impairment (MCI) from 53 studies in the multicenter Amyloid Biomarker Study...
November 29, 2017: JAMA Psychiatry
https://www.readbyqxmd.com/read/29187698/evaluation-of-schistosoma-japonicum-thioredoxin-peroxidase-1-as-a-potential-circulating-antigen-target-for-the-diagnosis-of-asian-schistosomiasis
#8
Adrian Miki C Macalanda, Jose Ma M Angeles, Kharleezelle J Moendeg, Anh Tm Dang, Luna Higuchi, Noboru Inoue, Xuenan Xuan, Masashi Kirinoki, Yuichi Chigusa, Lydia R Leonardo, Elena A Villacorte, Pilarita T Rivera, Yasuyuki Goto, Shin-Ichiro Kawazu
Asian schistosomiasis caused by Schistosoma japonicum is a serious zoonotic disease endemic in China, the Philippines and parts of Indonesia. Mass drug administration in endemic areas resulted to decline in disease severity and intensity. The low intensity of infection limits the use of current parasitological methods for schistosomiasis diagnosis. Detection of parasite circulating antigens might provide more informative result as it may indicate the true status of infection. In this study, S. japonicum thioredoxin peroxidase-1 (SjTPx-1) a 22 kDa secreted antioxidant enzyme expressed throughout the life stages of the parasite was evaluated for its potential use as a biomarker for schistosomiasis japonica infection...
November 28, 2017: Journal of Veterinary Medical Science
https://www.readbyqxmd.com/read/29174812/amino-acid-and-peptide-prodrugs-of-diphenylpropanones-positive-allosteric-modulators-of-%C3%AE-7-nicotinic-receptors-with-analgesic-activity
#9
Beatriz Balsera, José Mulet, Salvador Sala, Francisco Sala, Roberto de la Torre-Martínez, Sara González-Rodríguez, Adrián Plata, Lieve Naesens, Asia Fernández-Carvajal, Antonio Ferrer-Montiel, Manuel Criado, María Jesús Pérez de Vega, Rosario González-Muñiz
α7 Nicotinic acetylcholine receptors (nAChRs) are ion channels implicated in a number of CNS pathological processes, including pain and psychiatric, cognitive and inflammatory diseases. Comparing with orthosteric agonism, positive allosteric modulation of these channels constitutes an interesting approach to achieve selectivity versus other nicotinic receptors. We have recently described new chalcones and 1,3-diphenylpropanones as positive allosteric modulators (PAMs) of α7 nAChRs, which proved to have good analgesic activities but poor pharmacokinetic properties...
November 2, 2017: European Journal of Medicinal Chemistry
https://www.readbyqxmd.com/read/29163251/consumer-neuroscience-based-metrics-predict-recall-liking-and-viewing-rates-in-online-advertising
#10
Jaime Guixeres, Enrique Bigné, Jose M Ausín Azofra, Mariano Alcañiz Raya, Adrián Colomer Granero, Félix Fuentes Hurtado, Valery Naranjo Ornedo
The purpose of the present study is to investigate whether the effectiveness of a new ad on digital channels (YouTube) can be predicted by using neural networks and neuroscience-based metrics (brain response, heart rate variability and eye tracking). Neurophysiological records from 35 participants were exposed to 8 relevant TV Super Bowl commercials. Correlations between neurophysiological-based metrics, ad recall, ad liking, the ACE metrix score and the number of views on YouTube during a year were investigated...
2017: Frontiers in Psychology
https://www.readbyqxmd.com/read/29136639/structural-and-kinetic-considerations-on-the-catalysis-of-deoxyarbutin-by-tyrosinase
#11
Antonio Garcia-Jimenez, Jose Antonio Teruel-Puche, Pedro Antonio Garcia-Ruiz, Adrian Saura-Sanmartin, Jose Berna, Francisco Garcia-Canovas, José Neptuno Rodriguez-Lopez
Deoxyarbutin, a potent inhibitor of tyrosinase, could act as substrate of the enzyme. Oxytyrosinase is able to hydroxylate deoxyarbutin and finishes the catalytic cycle by oxidizing the formed o-diphenol to quinone, while the enzyme becomes deoxytyrosinase, which evolves to oxytyrosinase in the presence of oxygen. This compound is the only one described that does not release o-diphenol after the hydroxylation step. Oxytyrosinase hydroxylates the deoxyarbutin in ortho position of the phenolic hydroxyl group by means of an aromatic electrophilic substitution...
2017: PloS One
https://www.readbyqxmd.com/read/29136121/mechanical-thrombectomy-for-acute-ischemic-stroke-secondary-to-infective-endocarditis
#12
Juan Ambrosioni, Xabier Urra, Marta Hernández-Meneses, Manel Almela, Carlos Falces, Adrian Tellez, Eduard Quintana, David Fuster, Elena Sandoval, Barbara Vidal, Jose M Tolosana, Asunción Moreno, Angel Chamorro, José M Miró
Intravenous thrombolysis is contraindicated in acute ischemic stroke secondary to infective endocarditis. We report our initial experience of six cases with proximal vessel occlusion treated with mechanical thrombectomy. It was safe (no bleeding) and effective (significant, early neurological improvement) and might therefore be useful in this clinical setting.
November 9, 2017: Clinical Infectious Diseases: An Official Publication of the Infectious Diseases Society of America
https://www.readbyqxmd.com/read/29133410/unprecedented-pathway-of-reducing-equivalents-in-a-diflavin-linked-disulfide-oxidoreductase
#13
Rubén M Buey, Juan B Arellano, Luis López-Maury, Sergio Galindo-Trigo, Adrián Velázquez-Campoy, José L Revuelta, José M de Pereda, Francisco J Florencio, Peter Schürmann, Bob B Buchanan, Monica Balsera
Flavoproteins participate in a wide variety of physiologically relevant processes that typically involve redox reactions. Within this protein superfamily, there exists a group that is able to transfer reducing equivalents from FAD to a redox-active disulfide bridge, which further reduces disulfide bridges in target proteins to regulate their structure and function. We have identified a previously undescribed type of flavin enzyme that is exclusive to oxygenic photosynthetic prokaryotes and that is based on the primary sequence that had been assigned as an NADPH-dependent thioredoxin reductase (NTR)...
November 13, 2017: Proceedings of the National Academy of Sciences of the United States of America
https://www.readbyqxmd.com/read/29129759/dampening-of-the-bone-formation-response-following-repeat-dosing-with-sclerostin-antibody-in-mice-is-associated-with-up-regulation-of-wnt-antagonists
#14
Gill Holdsworth, Kevin Greenslade, Joby Jose, Zofia Stencel, Hishani Kirby, Adrian Moore, Hua Zhu Ke, Martyn K Robinson
Administration of antibodies to sclerostin (Scl-Ab) has been shown to increase bone mass, bone mineral density (BMD) and bone strength by increasing bone formation and decreasing bone resorption in both animal studies and human clinical trials. In these studies, the magnitude and rate of increase in bone formation markers is attenuated upon repeat dosing with Scl-Ab despite a continuous and progressive increase in BMD. Here, we investigated whether the attenuation in the bone formation response following repeated administration of Scl-Ab was associated with increased expression of secreted antagonists of Wnt signalling and determined how the circulating marker of bone formation, P1NP, responded to single, or multiple doses, of Scl-Ab four days post-dosing...
November 9, 2017: Bone
https://www.readbyqxmd.com/read/29120438/four-ethical-priorities-for-neurotechnologies-and-ai
#15
Rafael Yuste, Sara Goering, Blaise Agüera Y Arcas, Guoqiang Bi, Jose M Carmena, Adrian Carter, Joseph J Fins, Phoebe Friesen, Jack Gallant, Jane E Huggins, Judy Illes, Philipp Kellmeyer, Eran Klein, Adam Marblestone, Christine Mitchell, Erik Parens, Michelle Pham, Alan Rubel, Norihiro Sadato, Laura Specker Sullivan, Mina Teicher, David Wasserman, Anna Wexler, Meredith Whittaker, Jonathan Wolpaw
No abstract text is available yet for this article.
November 8, 2017: Nature
https://www.readbyqxmd.com/read/29115951/letter-to-the-editor-round-table-unites-to-tackle-culture-change-in-an-effort-to-improve-animal-research-reporting
#16
EDITORIAL
Nicola J Osborne, Merel Ritskes-Hoitinga, Amrita Ahluwahlia, Sabina Alam, Matthew Brown, Hayley Henderson, Wim de Leeuw, Joan Marsh, David Moher, Erica van Oort, Frances Rawle, Beat M Riederer, Jose Sanchez-Morgado, Emily S Sena, Caroline Struthers, Matthew Westmore, Marc T Avey, Rony Kalman, Annette O'Connor, Jan Sargeant, Anja Petrie, Adrian Smith
A round table discussion was held during the LAVA-ESLAV-ECLAM conference on Reproducibility of Animal Studies on the 25th of September 2017 in Edinburgh. The aim of the round table was to discuss how to enhance the rate at which the quality of reporting animal research can be improved. This signed statement acknowledges the efforts that participant organizations have made towards improving the reporting of animal studies and confirms an ongoing commitment to drive further improvements, calling upon both academics and laboratory animal veterinarians to help make this cultural change...
November 7, 2017: BMC Veterinary Research
https://www.readbyqxmd.com/read/29106631/effect-of-renin-angiotensin-aldosterone-system-blockade-in-adults-with-diabetes-mellitus-and-advanced-chronic-kidney-disease-not-on-dialysis-a-systematic-review-and-meta-analysis
#17
Ionut Nistor, Johan De Sutter, Christiane Drechsler, David Goldsmith, Maria Jose Soler, Charles Tomson, Andrzej Wiecek, Mihaela-Dora Donciu, Davide Bolignano, Wim Van Biesen, Adrian Covic
The presumed superiority of renin-angiotensin-aldosterone system (RAAS)-blocking agents over other antihypertensive agents in patients with diabetes to delay development of end-stage kidney disease (ESKD) has recently been challenged. In addition, there is ongoing uncertainty whether RAAS-blocking agents reduce mortality and/or delay ESKD in patients with diabetes and chronic kidney disease (CKD) stages 3-5. In this subgroup, there might be an expedited need for renal replacement therapy (RRT) when RAAS-blocking agents are used...
July 2, 2017: Nephrology, Dialysis, Transplantation
https://www.readbyqxmd.com/read/29102871/impact-of-multiple-sclerosis-on-quality-of-life-comparison-with-systemic-lupus-erythematosus
#18
Edgar Carnero Contentti, Néstor David Genco, Javier Pablo Hryb, Mercedes Caspi, Edson Chiganer, José Luis Di Pace, Pablo Adrián López, Carmen Lessa, Alejandro Caride, Mónica Perassolo
OBJECTIVE: To report the impact of multiple sclerosis (MS) on patients' quality of life (QoL) compared to systemic lupus erythematosus (SLE) using the 36-Item Short Form (SF-36) health questionnaire in Argentina. PATIENTS AND METHODS: Cross-sectional study. All consecutive MS patients, SLE and healthy controls (HC) were included. Demographics, clinical and radiological aspects, EDSS and SF-36 were assessed. RESULTS: A total of 191 subjects were included (MS=74, SLE=30 and HC=87)...
October 31, 2017: Clinical Neurology and Neurosurgery
https://www.readbyqxmd.com/read/29102505/validity-of-self-reported-intensity-of-exposure-to-second-hand-smoke-at-home-against-environmental-and-personal-markers
#19
José M Martínez-Sánchez, Adrián González-Marrón, Juan Carlos Martín-Sánchez, Xisca Sureda, Marcela Fu, Raúl Pérez-Ortuño, Cristina Lidón-Moyano, Iñaki Galán, José Antonio Pascual, Esteve Fernández
The objective of this study was to assess the validity of two questions about the perception of intensity of exposure to secondhand smoke (SHS) at home using as a reference environmental markers (airborne nicotine and benzene) and biomarkers of exposure (cotinine in saliva and urine). This was a cross-sectional study in a convenience sample of 49 non-smoking volunteers. We found a high correlation between self-reported SHS exposure and airborne nicotine (rsp=0.806, p<0.05), salivary cotinine (rsp=0.752, p<0...
November 1, 2017: Gaceta Sanitaria
https://www.readbyqxmd.com/read/29080822/action-of-tyrosinase-on-caffeic-acid-and-its-n-nonyl-ester-catalysis-and-suicide-inactivation
#20
Antonio Garcia-Jimenez, Jose Antonio Teruel-Puche, Pedro Antonio Garcia-Ruiz, Adrian Saura-Sanmartin, Jose Berna, Jose Neptuno Rodríguez-López, Francisco Garcia-Canovas
Different mechanisms for inhibiting tyrosinase can be designed to avoid postharvest quality losses of fruits and vegetables. The action of tyrosinase on caffeic acid and its n-nonyl ester (n-nonyl caffeate) was characterized kinetically in this work. The results lead us to propose that both compounds are suicide substrates of tyrosinase, for which we establish the catalytic and inactivation efficiencies. The ester is more potent as inactivator than the caffeic acid and the number of turnovers made by one molecule of the enzyme before its inactivation (r) is lower for the ester...
October 25, 2017: International Journal of Biological Macromolecules
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