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https://www.readbyqxmd.com/read/29660865/effect-of-genotype-and-crop-year-on-the-nutritional-value-of-walnut-virgin-oil-and-defatted-flour
#1
Adrián Rabadán, José E Pardo, Arturo Pardo-Giménez, Manuel Álvarez-Ortí
The present study analyses the health-promoting compounds of walnut oil and walnut defatted flour obtained using hydraulic pressing. To identify the cultivar effect, nine walnut varieties were harvested in the same plot for two years to control environmental and agricultural management effects on kernel chemical traits. Beyond the variability reported in the products obtained from the different cultivars analysed, the crop year showed a crucial effect in the nutritional value of walnut products. Specifically, the variability caused for the crop year in the concentration of oleic and linoleic acids, phytosterols, polyphenols, tocopherols, proteins and essential minerals (K, Mg, P, S, Cu, Fe, Mn, Mo, Ni) was greater that the reported for the genotype...
April 12, 2018: Science of the Total Environment
https://www.readbyqxmd.com/read/29660078/respirable-uranyl-vanadate-containing-particulate-matter-derived-from-a-legacy-uranium-mine-site-exhibits-potentiated-cardiopulmonary-toxicity
#2
Katherine E Zychowski, Vamsi Kodali, Molly Harmon, Christina Tyler, Bethany Sanchez, Yoselin Ordonez Suarez, Guy Herbert, Abigail Wheeler, Sumant Avasarala, José M Cerrato, Nitesh K Kunda, Pavan Muttil, Chris Shuey, Adrian Brearley, Abdul-Mehdi Ali, Yan Lin, Mohammad Shoeb, Aaron Erdely, Matthew J Campen
Background: Exposure to windblown particulate matter (PM) arising from legacy uranium (U) mine sites in the Navajo Nation may pose a human health hazard due to their potentially high metal content, including U and vanadium (V). Objective: To assess the toxic impact of PM derived from Claim 28 (a priority U mine) compared to background PM, and consider the putative role of metal species U and V. Methods: Two representative sediment samples from Navajo Nation sites (Background PM and Claim 28 PM) were obtained, characterized in terms of chemistry and morphology, and fractioned to the respirable (≤10μm) fraction...
April 5, 2018: Toxicological Sciences: An Official Journal of the Society of Toxicology
https://www.readbyqxmd.com/read/29655894/hhipl-1-rs2895811-gene-polymorphism-is-associated-with-cardiovascular-risk-factors-and-cardiometabolic-parameters-in-mexicans-patients-with-myocardial-infarction
#3
José Manuel Rodríguez-Pérez, Rosalinda Posadas-Sánchez, Ruben Blachman-Braun, Gilberto Vargas-Alarcón, Carlos Posadas-Romero, Adrián Asael Rodríguez-Cortés, Fabiola López-Bautista, Carlos Alfonso Tovilla-Zárate, Emma Xochitl Rojas-Toledo, Verónica Marusa Borgonio-Cuadra, Nonanzit Pérez-Hernández
Several studies have reported the role of hedgehog interacting protein-like 1 (HHIPL-1) in different pathologies, including cardiovascular disease. The aim of the present study was to analyze the association of HHIPL-1 (rs2895811) polymorphism with myocardial infarction (MI), cardiometabolic parameters, and traditional cardiovascular risk factors in the Mexican population. The polymorphism was genotyped using a TaqMan assay in 1023 patients with MI and 1105 controls. A similar distribution of the polymorphism was observed between studied groups...
April 12, 2018: Gene
https://www.readbyqxmd.com/read/29644961/high-intensity-exercise-induced-intestinal-damage-is-protected-by-fermented-milk-supplemented-with-whey-protein-probiotic-and-pomegranate-punica-granatum-l
#4
Fernanda M Chaves, Igor L Baptista, Fernando M Simabuco, Paula G F Quaresma, Fabiola L Pena, Rosangela M N Bezerra, Jose R Pauli, Diogo T da Cunha, Patricia L Campos-Ferraz, Adriane E C Antunes
Here we evaluated the effect of fermented milk supplemented with whey protein (approximately 80 % protein), probiotic (Bifidobacterium animalis subsp. lactis BB12) and pomegranate juice (Punica granatum L.) on the physical performance, intestinal motility and villi structure, inflammatory markers and intestinal microbiota of rats under high-intensity acute exercise. In all, twenty-four Wistar rats were separated into groups: control (Ctrl), supplemented (Supp), exercised (Exe) and exercised and supplemented (Exe+Supp)...
April 2018: British Journal of Nutrition
https://www.readbyqxmd.com/read/29611142/combined-transcranial-direct-current-stimulation-and-virtual-reality-based-paradigm-for-upper-limb-rehabilitation-in-individuals-with-restricted-movements-a-feasibility-study-with-a-chronic-stroke-survivor-with-severe-hemiparesis
#5
María Antonia Fuentes, Adrián Borrego, Jorge Latorre, Carolina Colomer, Mariano Alcañiz, María José Sánchez-Ledesma, Enrique Noé, Roberto Llorens
Impairments of the upper limb function are a major cause of disability and rehabilitation. Most of the available therapeutic options are based on active exercises and on motor and attentional inclusion of the affected arm in task oriented movements. However, active movements may not be possible after severe impairment of the upper limbs. Different techniques, such as mirror therapy, motor imagery, and non-invasive brain stimulation have been shown to elicit cortical activity in absence of movements, which could be used to preserve the available neural circuits and promote motor learning...
April 2, 2018: Journal of Medical Systems
https://www.readbyqxmd.com/read/29610194/the-combination-of-daptomycin-plus-fosfomycin-has-synergistic-potent-and-rapid-bactericidal-activity-against-methicillin-resistant-staphylococcus-aureus-mrsa-in-a-rabbit-model-of-experimental-endocarditis-ee
#6
Cristina García-de-la-Mària, Oriol Gasch, Javier García-Gonzalez, Dolors Soy, Evelyn Shaw, Juan Ambrosioni, Manel Almela, Juan M Pericàs, Adrián Tellez, Carlos Falces, Marta Hernandez-Meneses, Elena Sandoval, Eduard Quintana, Barbara Vidal, Jose M Tolosana, David Fuster, Jaume Llopis, Miquel Pujol, Asuncion Moreno, Francesc Marco, Jose M Miró
This study aims to investigate whether the addition of fosfomycin or cloxacillin to daptomycin provides better outcomes in the treatment of methicillin-resistant Staphylococcus aureus (MRSA) experimental aortic endocarditis in rabbits. Five MRSA strains were used to perform in vitro time-kill studies at standard (105) and high (108) inocula. Combined therapy was compared with daptomycin monotherapy treatment in the MRSA experimental endocarditis model. A human-like pharmacokinetics model was applied and the equivalents of cloxacillin 2g/4hiv, fosfomycin 2g/6h iv and daptomycin 6-10mg/kg/d iv were administered...
April 2, 2018: Antimicrobial Agents and Chemotherapy
https://www.readbyqxmd.com/read/29601787/prevalence-of-the-apolipoprotein-e-%C3%AE%C2%B54-allele-in-amyloid-%C3%AE-positive-subjects-across-the-spectrum-of-alzheimer-s-disease
#7
Niklas Mattsson, Colin Groot, Willemijn J Jansen, Susan Landau, Victor Villemagne, Sebastiaan Engelborghs, Mark Mintun, Alberto Lleo, José Luis Molinuevo, William Jagust, Giovanni B Frisoni, Adrian Ivanoiu, Gaël Chételat, Catarina Resende de Oliveira, Karen M Rodrigue, Johannes Kornhuber, Anders Wallin, Aleksandra Klimkowicz-Mrowiec, Ramesh Kandimella, Julius Popp, Pauline P Aalten, Dag Aarsland, Daniel Alcolea, Ina S Almdahl, Inês Baldeiras, Mark A van Buchem, Enrica Cavedo, Kewei Chen, Ann D Cohen, Stefan Förster, Juan Fortea, Kristian S Frederiksen, Yvonne Freund-Levi, Kiran Dip Gill, Olymbia Gkatzima, Timo Grimmer, Harald Hampel, Sanna-Kaisa Herukka, Peter Johannsen, Koen van Laere, Mony de Leon, Wolfgang Maier, Jan Marcusson, Olga Meulenbroek, Hanne M Møllergård, John C Morris, Barbara Mroczko, Arto Nordlund, Sudesh Prabhakar, Oliver Peters, Lorena Rami, Eloy Rodríguez-Rodríguez, Catherine M Roe, Eckart Rüther, Isabel Santana, Johannes Schröder, Sang W Seo, Hilkka Soininen, Luiza Spiru, Erik Stomrud, Hanne Struyfs, Charlotte E Teunissen, Frans R J Verhey, Stephanie J B Vos, Linda J C van Waalwijk van Doorn, Gunhild Waldemar, Åsa K Wallin, Jens Wiltfang, Rik Vandenberghe, David J Brooks, Tormod Fladby, Christopher C Rowe, Alexander Drzezga, Marcel M Verbeek, Marie Sarazin, David A Wolk, Adam S Fleisher, William E Klunk, Duk L Na, Pascual Sánchez-Juan, Dong Young Lee, Agneta Nordberg, Magda Tsolaki, Vincent Camus, Juha O Rinne, Anne M Fagan, Henrik Zetterberg, Kaj Blennow, Gil D Rabinovici, Oskar Hansson, Bart N M van Berckel, Wiesje M van der Flier, Philip Scheltens, Pieter Jelle Visser, Rik Ossenkoppele
INTRODUCTION: Apolipoprotein E (APOE) ε4 is the major genetic risk factor for Alzheimer's disease (AD), but its prevalence is unclear because earlier studies did not require biomarker evidence of amyloid β (Aβ) pathology. METHODS: We included 3451 Aβ+ subjects (853 AD-type dementia, 1810 mild cognitive impairment, and 788 cognitively normal). Generalized estimating equation models were used to assess APOE ε4 prevalence in relation to age, sex, education, and geographical location...
March 27, 2018: Alzheimer's & Dementia: the Journal of the Alzheimer's Association
https://www.readbyqxmd.com/read/29569254/stem-cell-therapy-in-st-segment-elevation-myocardial-infarction-with-reduced-ejection-fraction-a-multicenter-double-blind-randomized-trial
#8
José C Nicolau, Remo H M Furtado, Suzana A Silva, Carlos E Rochitte, Anis Rassi, João B M C Moraes, Edgard Quintella, Costantino R Costantini, Adrian P M Korman, Marco A Mattos, Hélio J Castello, Adriano Caixeta, Hans F R Dohmann, Antonio C C de Carvalho
BACKGROUND: Left ventricular ejection fraction (LVEF) is a major determinant of long-term prognosis after ST-segment elevation myocardial infarction (STEMI). STEMI patients with reduced LVEF have a poor prognosis, despite successful reperfusion and the use of renin-angiotensin-aldosterone inhibitors. HYPOTHESIS: Intracoronary infusion of bone marrow-derived mononuclear cells (BMMC) may improve LVEF in STEMI patients successfully reperfused. METHODS: The main inclusion criteria for this double-blind, randomized, multicenter study were patient age 30 to 80 years, LVEF ≤50%, successful angioplasty of infarct-related artery, and regional dysfunction in the infarct-related area analyzed before cell injection...
March 22, 2018: Clinical Cardiology
https://www.readbyqxmd.com/read/29567403/comparisons-of-schizotypal-traits-across-12-countries-results-from-the-international-consortium-for-schizotypy-research
#9
Eduardo Fonseca-Pedrero, Raymond C K Chan, Martin Debbané, David Cicero, Lisa C Zhang, Colleen Brenner, Emma Barkus, Richard J Linscott, Thomas Kwapil, Neus Barrantes-Vidal, Alex Cohen, Adrian Raine, Michael T Compton, Erin B Tone, Julie Suhr, José Muñiz, Alicia Pérez de Albéniz, Axit Fumero, Stella Giakoumaki, Ioannis Tsaousis, Antonio Preti, Michael Chmielewski, Julien Laloyaux, Anwar Mechri, Mohamed Aymen Lahmar, Viviana Wuthrich, Frank Larøi, Johanna C Badcock, Assen Jablensky, Javier Ortuño-Sierra
BACKGROUND: Schizotypal traits are expressions of underlying vulnerability to psychotic disorders which have a potential impact on mental health status, neurocognition, quality of life, and daily functioning. To date, little research has examined epidemiologic landscape of schizotypal traits at the cross-national level. Our aim was to study the expression of schizotypal traits by sex, age, and country in a combined sample gathered from 12 countries. METHODS: A total of 27,001 participants completed the Schizotypal Personality Questionnaire (SPQ)...
March 19, 2018: Schizophrenia Research
https://www.readbyqxmd.com/read/29564940/quantitative-measurement-of-oxidative-damage-in-erythrocytes-as-indicator-in-benzene-intoxications
#10
José Luis Martínez-Rodríguez, Rosalinda Gutiérrez-Hernández, Claudia Araceli Reyes-Estrada, Angelica Judith Granados-López, Tatiana Arcos-Ortega, Jesús Adrián López
The metabolism of aromatic hydrocarbons by the organism forms products that cause cell death depending on the type of exposure. Benzene exposure has been linked to oxidative stress, hepatic damage, aplastic anemia and hematopoietic cancer as lymphoid and myeloid leukemia. However, there are not fast methods to evaluate chronically benzene exposure in human blood. The objective of this work was the evaluation of the correlation between oxidative damage with benzene exposure and the level of Cellular Plasma Membrane Stability (CPMS) in erythrocytes to use it as a future indicator to determine the grade of benzene intoxications...
March 22, 2018: Toxicology Mechanisms and Methods
https://www.readbyqxmd.com/read/29557041/tio-2-based-fe-3-o-4-sio-2-reduced-graphene-oxide-magnetically-recoverable-photocatalysts-for-imazalil-degradation-in-a-synthetic-wastewater
#11
Dunia E Santiago, Luisa M Pastrana-Martínez, Elisenda Pulido-Melián, Javier Araña, Joaquim L Faria, Adrián M T Silva, Óscar González-Díaz, José M Doña-Rodríguez
Magnetite (Fe3 O4 ), a core-shell material (SiO2 @Fe3 O4 ), and reduced graphene oxide-Fe3 O4 (referred as rGO-MN) were used as supports of a specific highly active TiO2 photocatalyst. Thermal treatments at 200 or 450 °C, different atmospheres (air or N2 ), and TiO2 :support weight ratios (1.0, 1.5, or 2.0) were investigated. X-ray diffractograms revealed that magnetite is not oxidized to hematite when the core-shell SiO2 @Fe3 O4 material-or a N2 atmosphere (instead of air) in the thermal treatment-was employed to prepare the TiO2 -based catalysts (the magnetic properties being preserved)...
March 2, 2018: Environmental Science and Pollution Research International
https://www.readbyqxmd.com/read/29551403/paediatric-asthma-treatment-what-to-do-when-international-guidelines-recommendations-don-t-agree
#12
Désirée E S Larenas Linnemann, Margarita Fernández Vega, Jorge Agustín Luna Pech, Jimena Villaverde Rosas, José Antonio Ortega Martell, Blanca Estela Del Río Navarro, María Del Carmen Cano Salas, Jade Romero Lombard, Erika Del Carmen López Estrada, Monica Rodriguez-González, José Luis Mayorga Butrón, Jorge Salas Hernández, Juan Carlos Vázquez García, Ignacio Ortiz Aldana, Mario Humberto Vargas Becerra, Martín Bedolla Barajas, Noel Rodríguez Pérez, Ambrocio Aguilar Aranda, Carlos Adrián Jiménez González, Carlos García Bolaños, Claudia Garrido Galindo, David Alejandro Mendoza Hernández, Enrique Mendoza López, Gerardo López Pérez, Guillermo Hideo Wakida Kuzonoki, Héctor Hernán Ruiz Gutiérrez, Héctor León Molina, Héctor Martínez de la Lanza, Héctor Stone Aguilar, Javier Gómez Vera, Jorge Olvera Salinas, José Joel Oyoqui Flores, José Luis Gálvez Romero, José Santos Lozano Saenz, Juan Ignacio Salgado Gama, Marcos Alejandro Jiménez Chobillon, Martha Angélica García Avilés, Martha Patricia Guinto Balanzar, Miguel Alejandro Medina Ávalos, Robert Camargo Angeles, Rogelio García Torrentera, Saraí Toral Freyre, Gabriel Montes Narvaez, Héctor Solorio Gómez, Juan Rosas Peña, Sergio Jesús Romero Tapia, Adela Reyes Herrera, Francisco Cuevas Schacht, Joaquín Esquer Flores, José Antonio Sacre Hazouri, Lorenzo Compean Martínez, Pablo Julián Medina Sánchez, Sergio Garza Salinas, Carlos Baez Loyola, Iraís Romero Alvarado, José Luis Miguel Reyes, Laura Elizabeth Huerta Espinosa, Manuel Ángel Correa Flores, Ricardo Castro Martínez
No abstract text is available yet for this article.
March 15, 2018: Annals of Allergy, Asthma & Immunology
https://www.readbyqxmd.com/read/29530795/amphipathic-helical-peptides-hamper-protein-protein-interactions-of-the-intrinsically-disordered-chromatin-nuclear-protein-1-nupr1
#13
Patricia Santofimia-Castaño, Bruno Rizzuti, Olga Abián, Adrián Velázquez-Campoy, Juan L Iovanna, José L Neira
BACKGROUND: NUPR1 is a multifunctional intrinsically disordered protein (IDP) involved, among other functions, in chromatin remodelling, and development of pancreatic ductal adenocarcinoma (PDAC). It interacts with several biomolecules through hydrophobic patches around residues Ala33 and Thr68. The drug trifluoperazine (TFP), which hampers PDAC development in xenografted mice, also binds to those regions. Because of the large size of the hot-spot interface of NUPR1, small molecules could not be adequate to modulate its functions...
March 9, 2018: Biochimica et Biophysica Acta
https://www.readbyqxmd.com/read/29490589/school-of-medicine-of-federal-university-of-rio-grande-do-norte-a-traditional-curriculum-with-innovative-trends-in-medical-education
#14
Daniel Fernandes Mello De Oliveira, Breno C C Simas, Adrian Lucca Guimarães Caldeira, Augusto De Galvão E Brito Medeiros, Marise Reis Freitas, José Diniz, Rosiane Diniz
INTRODUCTION: The Medical School of the Federal University of Rio Grande do Norte (UFRN) is one of the biggest public medical schools in Northeast Brazil. In the last decade, significant investment in faculty development, innovative learning methodologies and student engagement has been key milestones in educational improvement at this medical school, harnessed to recent political changes that strengthened community-based and emergency education. This study describes how curriculum changes in UFRN Medical School have been responsible for major improvements in medical education locally and which impacts such transformations may have on the educational community...
February 28, 2018: Medical Teacher
https://www.readbyqxmd.com/read/29477517/invited-review-bioactive-compounds-produced-during-cheese-ripening-and-health-effects-associated-with-aged-cheese-consumption
#15
Lourdes Santiago-López, Jose E Aguilar-Toalá, Adrián Hernández-Mendoza, Belinda Vallejo-Cordoba, Andrea M Liceaga, Aarón F González-Córdova
Traditionally, cheese is manufactured by converting fluid milk to a semisolid mass through the use of a coagulating agent, such as rennet, acid, heat plus acid, or a combination thereof. Cheese can vary widely in its characteristics, including color, aroma, texture, flavor, and firmness, which can generally be attributed to the production technology, source of the milk, moisture content, and length of aging, in addition to the presence of specific molds, yeast, and bacteria. Among the most important bacteria, lactic acid bacteria (LAB) play a critical role during the cheese-making process...
February 21, 2018: Journal of Dairy Science
https://www.readbyqxmd.com/read/29476766/attitudes-towards-tobacco-product-regulations-and-their-relationship-with-the-tobacco-control-policies
#16
Cristina Lidón-Moyano, Marc Sampedro-Vida, Nuria Matilla-Santander, Juan Carlos Martín-Sánchez, Adrián González-Marrón, Kailey Bunch, Jose M Martínez-Sánchez
The objective of this work is to describe the acceptability of some tobacco products regulations and to explore their relation with tobacco control legislation levels in Europe. We used data on tobacco control activities in Europe in 2007, 2010 and 2013 measured by the Tobacco Control Scale (TCS) and data regarding attitudes about tobacco control regulations (i.e. adding picture health warnings on all packages of tobacco products or increasing taxes on tobacco products) from the Special Eurobarometer of 2009, 2012 and 2014 (n = 80,831)...
February 21, 2018: Preventive Medicine
https://www.readbyqxmd.com/read/29473411/levamisole-a-common-adulterant-in-cocaine-street-samples-hindering-electrochemical-detection-of-cocaine
#17
Mats de Jong, Anca Florea, Anne-Mare de Vries, Alexander L N van Nuijs, Adrian Covaci, Filip Van Durme, Jose C Martins, Nele Samyn, Karolien De Wael
The present work investigates the electrochemical determination of cocaine in the presence of levamisole, one of the most common adulterants found in cocaine street samples. Levamisole misleads cocaine colour tests, giving a blue colour (positive test) even in the absence of cocaine. Moreover, the electrochemical detection of cocaine is also affected by the presence of levamisole, with a suppression of the oxidation signal of cocaine. When levamisole is present in the sample in ratios higher than 1:1, the cocaine signal is no longer detected, thus leading to false negative results...
February 23, 2018: Analytical Chemistry
https://www.readbyqxmd.com/read/29472993/life-histories-predict-genetic-diversity-and-population-structure-within-three-species-of-octopus-targeted-by-small-scale-fisheries-in-northwest-mexico
#18
José F Domínguez-Contreras, Adrian Munguia-Vega, Bertha P Ceballos-Vázquez, Marcial Arellano-Martínez, Francisco J García-Rodríguez, Melanie Culver, Hector Reyes-Bonilla
The fishery for octopus in Northwest Mexico has increased to over 2,000 tons annually, but to date the specific composition of the catch has been ignored. With at least three main species targeted by artisanal fisheries in the region with distinct life histories, the lack of basic biological information about the distribution, metapopulation size and structure of each species could impede effective fisheries management to avoid overexploitation. We tested if different life histories of three species of octopus could help predict observed patterns of genetic diversity, population dynamics, structure and connectivity and how this information could be relevant to the sustainable management of the fishery...
2018: PeerJ
https://www.readbyqxmd.com/read/29469048/results-of-liver-transplantation-for-hepatocellular-carcinoma-in-a-multicenter-latin-american-cohort-study
#19
Federico Piñero, Paulo Costa, Yuri L Boteon, Sergio Hoyos Duque, Sebastian Marciano, Margarita Anders, Adriana Varón, Alina Zerega, Jaime Poniachik, Alejandro Soza, Martín Padilla Machaca, Josemaría Menéndez, Rodrigo Zapata, Mario Vilatoba, Linda Muñoz, Martín Maraschio, Martín Fauda, Lucas McCormack, Adrian Gadano, Ilka Sf Boin, Jose H Parente García, Marcelo Silva
BACKGROUND AND AIMS: Heterogeneous data has been reported regarding liver transplantation (LT) for hepatocellular carcinoma (HCC) in Latin America. We aimed to describe treatment during waiting list, survival and recurrence of HCC after LT in a multicenter study from Latin America. MATERIAL AND METHODS: Patients with HCC diagnosed prior to transplant (cHCC) and incidentally found in the explanted liver (iHCC) were included. Imaging-explanted features were compared in cHCC (non-discordant if pre and post-LT were within Milan, discordant if pre-LT was within and post-LT exceeding Milan)...
March 1, 2018: Annals of Hepatology
https://www.readbyqxmd.com/read/29468647/brentuximab-vedotin-prior-to-allogeneic-stem-cell-transplantation-in-hodgkin-lymphoma-a-report-from-the-ebmt-lymphoma-working-party
#20
Ali Bazarbachi, Ariane Boumendil, Hervé Finel, Mohamad Mohty, Luca Castagna, Karl S Peggs, Didier Blaise, Boris Afanasyev, José L Diez-Martin, Jorge Sierra, Adrian Bloor, Carmen Martinez, Stephen Robinson, Ram Malladi, Jean El-Cheikh, Paolo Corradini, Silvia Montoto, Peter Dreger, Anna Sureda
Brentuximab vedotin (BV) is an anti-CD30 antibody-drug conjugate. Preliminary data suggest that BV might improve outcomes after allogeneic stem cell transplantation (SCT) for Hodgkin lymphoma (HL) when used as pre-transplant salvage therapy. Between 2010 and 2014, 428 adult patients underwent an allogeneic SCT for classical HL at participating centres of the European Society for Blood and Marrow Transplantation. We compared the outcomes of 210 patients who received BV prior to allogeneic SCT with that of 218 patients who did not receive BV...
February 22, 2018: British Journal of Haematology
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