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https://www.readbyqxmd.com/read/27910224/separating-and-identifying-the-four-stereoisomers-of-methyl-jasmonate-by-rp-hplc-and-using-cyclodextrins-in-a-novel-way
#1
Adrián Matencio, Mario J Bermejo-Gimeno, Francisco García-Carmona, José Manuel López-Nicolás
INTRODUCTION: Several authors have reported on the different bioactivities of methyl jasmonate (MeJA) stereoisomers. However, no simple, precise and cheap method for separating and identifying them using reversed-phase high performance liquid chromatography (RP-HPLC) has been developed. OBJECTIVE: (1) To create a simple, precise and cheap method for separating and identifying the four stereoisomers present in commercial racemic mixtures of MeJA and (2) to identify the four stereoisomers using molecular docking techniques and coinjection...
December 2, 2016: Phytochemical Analysis: PCA
https://www.readbyqxmd.com/read/27867538/classification-of-drugs-to-treat-multidrug-resistant-tuberculosis-mdr-tb-evidence-and-perspectives
#2
EDITORIAL
Adrian Rendon, Simon Tiberi, Anna Scardigli, Lia D'Ambrosio, Rosella Centis, Jose A Caminero, Giovanni Battista Migliori
No abstract text is available yet for this article.
October 2016: Journal of Thoracic Disease
https://www.readbyqxmd.com/read/27864607/computed-tomography-versus-invasive-coronary-angiography-design-and-methods-of-the-pragmatic-randomised-multicentre-discharge-trial
#3
Adriane E Napp, Robert Haase, Michael Laule, Georg M Schuetz, Matthias Rief, Henryk Dreger, Gudrun Feuchtner, Guy Friedrich, Miloslav Špaček, Vojtěch Suchánek, Klaus Fuglsang Kofoed, Thomas Engstroem, Stephen Schroeder, Tanja Drosch, Matthias Gutberlet, Michael Woinke, Pál Maurovich-Horvat, Béla Merkely, Patrick Donnelly, Peter Ball, Jonathan D Dodd, Martin Quinn, Luca Saba, Maurizio Porcu, Marco Francone, Massimo Mancone, Andrejs Erglis, Ligita Zvaigzne, Antanas Jankauskas, Gintare Sakalyte, Tomasz Harań, Malgorzata Ilnicka-Suckiel, Nuno Bettencourt, Vasco Gama-Ribeiro, Sebastian Condrea, Imre Benedek, Nada Čemerlić Adjić, Oto Adjić, José Rodriguez-Palomares, Bruno Garcia Del Blanco, Giles Roditi, Colin Berry, Gershan Davis, Erica Thwaite, Juhani Knuuti, Mikko Pietilä, Cezary Kępka, Mariusz Kruk, Radosav Vidakovic, Aleksandar N Neskovic, Ignacio Díez, Iñigo Lecumberri, Jacob Geleijns, Christine Kubiak, Anke Strenge-Hesse, The-Hoang Do, Felix Frömel, Iñaki Gutiérrez-Ibarluzea, Gaizka Benguria-Arrate, Hans Keiding, Christoph Katzer, Jacqueline Müller-Nordhorn, Nina Rieckmann, Mario Walther, Peter Schlattmann, Marc Dewey
OBJECTIVES: More than 3.5 million invasive coronary angiographies (ICA) are performed in Europe annually. Approximately 2 million of these invasive procedures might be reduced by noninvasive tests because no coronary intervention is performed. Computed tomography (CT) is the most accurate noninvasive test for detection and exclusion of coronary artery disease (CAD). To investigate the comparative effectiveness of CT and ICA, we designed the European pragmatic multicentre DISCHARGE trial funded by the 7th Framework Programme of the European Union (EC-GA 603266)...
November 18, 2016: European Radiology
https://www.readbyqxmd.com/read/27855057/-sensitivity-and-antibiotic-resistance-in-infections-of-the-musculoskeletal-system
#4
Argenis Mata-Hernández, Adrián Huematzin Rivera-Villa, Adrián Miguel-Pérez, José Manuel Pérez-Atanasio, Rubén Torres-González
BACKGROUND: Infections of the musculoskeletal system are a devastating complication for patients, due to it's long rehabilitation process and even sometimes the removal of the implant, the chronicity of infection, is often due to lack of coverage in empirical antibiotics. METHODS: A retrospective, observational, descriptive cohort study was performed. All cultures form musculoskeletal system infected patients reported of sensitivity and resistance of germs isolated were analyzed...
2016: Revista Médica del Instituto Mexicano del Seguro Social
https://www.readbyqxmd.com/read/27855056/-mixed-knee-arthrodesis-a-rescue-alternative-in-knee-periprosthetic-joint-infection
#5
Roberto Enrique López-Cervantes, Adrián Huematzin Rivera-Villa, Adrián Miguel-Pérez, René Morales-de Los Santos, Rubén Torres-González, José Manuel Pérez-Atanasio
BACKGROUND: Knee arthrodesis is a rescue procedure for patients with knee periprosthetic joint infection who are not candidates for a revision surgery. The actual methods present a high complication rate with only moderate efectivity. METHODS: We retrospectively analyzed 17 cases, of patients with knee periprosthetic joint infection and bone loss treated by intramedular expandable nail and monoplanar external fixator with a mínimum evolution of 1 year, evaluating the medical records and digitalized X-rays by 2 sub specialized doctors in osteoarticular rescue surgery...
2016: Revista Médica del Instituto Mexicano del Seguro Social
https://www.readbyqxmd.com/read/27854069/a-conceptual-framework-for-understanding-illegal-killing-of-large-carnivores
#6
REVIEW
Neil H Carter, José Vicente López-Bao, Jeremy T Bruskotter, Meredith Gore, Guillaume Chapron, Arlyne Johnson, Yaffa Epstein, Mahendra Shrestha, Jens Frank, Omar Ohrens, Adrian Treves
The growing complexity and global nature of wildlife poaching threaten the survival of many species worldwide and are outpacing conservation efforts. Here, we reviewed proximal and distal factors, both social and ecological, driving illegal killing or poaching of large carnivores at sites where it can potentially occur. Through this review, we developed a conceptual social-ecological system framework that ties together many of the factors influencing large carnivore poaching. Unlike most conservation action models, an important attribute of our framework is the integration of multiple factors related to both human motivations and animal vulnerability into feedbacks...
November 16, 2016: Ambio
https://www.readbyqxmd.com/read/27829791/resurrection-of-anolis-ustus-cope-1864-from-synonymy-with-anolis-sericeus-hallowell-1856-squamata-dactyloidae
#7
José Daniel Lara-Tufiño, Adrián Nieto-Montes de Oca, Aurelio Ramírez-Bautista, Levi N Gray
In this study, based on a morphological analysis, the resurrection of the name Anolis ustus Cope 1864, is proposed for populations from the Yucatán Peninsula (Campeche, Yucatán, and Quintana Roo, Mexico, and Belize), formerly referred as Anolis sericeus Hallowell, 1856. Anolis ustus differs from Anolis sericeus by its mean snout-vent length and number of gorgetal scales in males, in tibia length and head width in females, and dorsal and ventral scales for both sexes. In addition, Anolis ustus has a small dewlap of similar size between males and females, whereas in Anolis sericeus males have a dewlap much larger than that of the females...
2016: ZooKeys
https://www.readbyqxmd.com/read/27811056/cxcr4-identifies-transitional-bone-marrow-premonocytes-that-replenish-the-mature-monocyte-pool-for-peripheral-responses
#8
Shu Zhen Chong, Maximilien Evrard, Sapna Devi, Jinmiao Chen, Jyue Yuan Lim, Peter See, Yiru Zhang, José M Adrover, Bernett Lee, Leonard Tan, Jackson L Y Li, Ka Hang Liong, Cindy Phua, Akhila Balachander, Adrian Boey, David Liebl, Suet Mien Tan, Jerry K Y Chan, Karl Balabanian, John E Harris, Mariaelvy Bianchini, Christian Weber, Johan Duchene, Josephine Lum, Michael Poidinger, Qingfeng Chen, Laurent Rénia, Cheng-I Wang, Anis Larbi, Gwendalyn J Randolph, Wolfgang Weninger, Mark R Looney, Matthew F Krummel, Subhra K Biswas, Florent Ginhoux, Andrés Hidalgo, Françoise Bachelerie, Lai Guan Ng
It is well established that Ly6C(hi) monocytes develop from common monocyte progenitors (cMoPs) and reside in the bone marrow (BM) until they are mobilized into the circulation. In our study, we found that BM Ly6C(hi) monocytes are not a homogenous population, as current data would suggest. Using computational analysis approaches to interpret multidimensional datasets, we demonstrate that BM Ly6C(hi) monocytes consist of two distinct subpopulations (CXCR4(hi) and CXCR4(lo) subpopulations) in both mice and humans...
October 17, 2016: Journal of Experimental Medicine
https://www.readbyqxmd.com/read/27806673/sprint-performance-and-mechanical-outputs-computed-with-an-iphone-app-comparison-with-existing-reference-methods
#9
Natalia Romero-Franco, Pedro Jiménez-Reyes, Adrián Castaño-Zambudio, Fernando Capelo-Ramírez, Juan José Rodríguez-Juan, Jorge González-Hernández, Francisco Javier Toscano-Bendala, Víctor Cuadrado-Peñafiel, Carlos Balsalobre-Fernández
The purpose of this study was to assess validity and reliability of sprint performance outcomes measured with an iPhone application (named: MySprint) and existing field methods (i.e. timing photocells and radar gun). To do this, 12 highly trained male sprinters performed 6 maximal 40-m sprints during a single session which were simultaneously timed using 7 pairs of timing photocells, a radar gun and a newly developed iPhone app based on high-speed video recording. Several split times as well as mechanical outputs computed from the model proposed by Samozino et al...
November 3, 2016: European Journal of Sport Science
https://www.readbyqxmd.com/read/27797291/everolimus-eluting-stents-or-bypass-surgery-for-left-main-coronary-artery-disease
#10
Gregg W Stone, Joseph F Sabik, Patrick W Serruys, Charles A Simonton, Philippe Généreux, John Puskas, David E Kandzari, Marie-Claude Morice, Nicholas Lembo, W Morris Brown, David P Taggart, Adrian Banning, Béla Merkely, Ferenc Horkay, Piet W Boonstra, Ad J van Boven, Imre Ungi, Gabor Bogáts, Samer Mansour, Nicolas Noiseux, Manel Sabaté, José Pomar, Mark Hickey, Anthony Gershlick, Pawel Buszman, Andrzej Bochenek, Erick Schampaert, Pierre Pagé, Ovidiu Dressler, Ioanna Kosmidou, Roxana Mehran, Stuart J Pocock, A Pieter Kappetein
Background Patients with obstructive left main coronary artery disease are usually treated with coronary-artery bypass grafting (CABG). Randomized trials have suggested that drug-eluting stents may be an acceptable alternative to CABG in selected patients with left main coronary disease. Methods We randomly assigned 1905 eligible patients with left main coronary artery disease of low or intermediate anatomical complexity to undergo either percutaneous coronary intervention (PCI) with fluoropolymer-based cobalt-chromium everolimus-eluting stents (PCI group, 948 patients) or CABG (CABG group, 957 patients)...
October 31, 2016: New England Journal of Medicine
https://www.readbyqxmd.com/read/27759919/a-synthesis-of-radial-growth-patterns-preceding-tree-mortality
#11
Maxime Cailleret, Steven Jansen, Elisabeth M R Robert, Lucía Desoto, Tuomas Aakala, Joseph A Antos, Barbara Beikircher, Christof Bigler, Harald Bugmann, Marco Caccianiga, Vojtěch Čada, J Julio Camarero, Paolo Cherubini, Hervé Cochard, Marie R Coyea, Katarina Čufar, Adrian J Das, Hendrik Davi, Sylvain Delzon, Michael Dorman, Guillermo Gea-Izquierdo, Sten Gillner, Laurel J Haavik, Henrik Hartmann, Ana-Maria Hereş, Kevin R Hultine, Pavel Janda, Jeffrey M Kane, Vyacheslav I Kharuk, Thomas Kitzberger, Tamir Klein, Koen Kramer, Frederic Lens, Tom Levanic, Juan Carlos Linares Calderon, Francisco Lloret, Raquel Lobo-Do-Vale, Fabio Lombardi, Rosana López Rodríguez, Harri Mäkinen, Stefan Mayr, Ilona Mészáros, Juha M Metsaranta, Francesco Minunno, Walter Oberhuber, Andreas Papadopoulos, Mikko Peltoniemi, Any Mary Petritan, Brigitte Rohner, Gabriel Sangüesa-Barreda, Dimitrios Sarris, Jeremy M Smith, Amanda B Stan, Frank Sterck, Dejan B Stojanović, Maria Laura Suarez, Miroslav Svoboda, Roberto Tognetti, José M Torres-Ruiz, Volodymyr Trotsiuk, Ricardo Villalba, Floor Vodde, Alana R Westwood, Peter H Wyckoff, Nikolay Zafirov, Jordi Martínez-Vilalta
Tree mortality is a key factor influencing forest functions and dynamics, but our understanding of the mechanisms leading to mortality and the associated changes in tree growth rates are still limited. We compiled a new pan-continental tree-ring width database from sites where both dead and living trees were sampled (2,970 dead and 4,224 living trees from 190 sites, including 36 species), and compared early and recent growth rates between trees that died and those that survived a given mortality event. We observed a decrease in radial growth before death in ca...
October 19, 2016: Global Change Biology
https://www.readbyqxmd.com/read/27759799/-basic-questionnaire-and-methodological-criteria-for-surveys-on-working-conditions-employment-and-health-in-latin-america-and-the-caribbean
#12
Fernando G Benavides, Pamela Merino-Salazar, Cecilia Cornelio, Ada Avila Assunção, Andrés A Agudelo-Suárez, Marcelo Amable, Lucía Artazcoz, Jonh Astete, Douglas Barraza, Fabián Berhó, Lino Carmenate Milián, George Delclòs, Lorena Funcasta, Johanna Gerke, David Gimeno, María José Itatí-Iñiguez, Eduardo de Paula Lima, David Martínez-Iñigo, Adriane Mesquita de Medeiros, Lida Orta, Javier Pinilla, Fernando Rodrigo, Marianela Rojas, Iselle Sabastizagal, Clelia Vallebuona, Greet Vermeylen, Gloria H Villalobos, Alejandra Vives
This article aimed to present a basic questionnaire and minimum methodological criteria for consideration in future Surveys on Working Conditions, Employment, and Health in Latin America and the Caribbean. A virtual and face-to-face consensus process was conducted with participation by a group of international experts who used the surveys available up until 2013 as the point of departure for defining the proposal. The final questionnaire included 77 questions grouped in six dimensions: socio-demographic characteristics of workers and companies; employment conditions; working conditions; health status; resources and preventive activities; and family characteristics...
October 10, 2016: Cadernos de Saúde Pública
https://www.readbyqxmd.com/read/27746189/characterization-and-comparative-analysis-of-the-genome-of-puccinia-sorghi-schwein-the-causal-agent-of-maize-common-rust
#13
Lucia Rochi, María José Diéguez, Germán Burguener, Martín Alejandro Darino, María Fernanda Pergolesi, Lorena Romina Ingala, Alba Romina Cuyeu, Adrián Turjanski, Enrique Domingo Kreff, Francisco Sacco
Rust fungi are one of the most devastating pathogens of crop plants. The biotrophic fungus Puccinia sorghi Schwein (Ps) is responsible for maize common rust, an endemic disease of maize (Zea mays L) in Argentina that causes significant yield losses in corn production. In spite of this, the Ps genomic sequence was not available. We used Illumina sequencing to rapidly produce the 99.6 Mb draft genome sequence of Ps race RO10H11247, derived from a single-uredinial isolate from infected maize leaves collected in the Argentine Corn Belt Region during 2010...
October 13, 2016: Fungal Genetics and Biology: FG & B
https://www.readbyqxmd.com/read/27723084/isolation-of-primary-fibroblast-culture-from-wildlife-the-panthera-onca-case-to-preserve-a-south-american-endangered-species
#14
Ana Cecilia Mestre-Citrinovitz, Adrián Jorge Sestelo, María Belén Ceballos, José Lino Barañao, Patricia Saragüeta
Cell line establishment of somatic cells is a valuable resource to preserve genetic material of rare, difficult-to-find, endangered and giant species like Jaguar (Panthera onca), the largest South American felid. This unit focuses on the isolation and culture of fibroblasts from Jaguar skin and muscle biopsies, and ear cartilage dissection immediately after death to preserve one of the several endangered species in this biome. These culture techniques enabled us to contribute 570 samples from 45 autochthonous and endangered species, including Jaguar...
October 10, 2016: Current Protocols in Molecular Biology
https://www.readbyqxmd.com/read/27716759/-correlation-between-the-presence-and-intensity-of-symptoms-and-the-results-of-hydrogen-breath-tests-in-the-diagnosis-of-carbohydrate-intolerance
#15
María Teresa Sánchez-Ávila, Karla Lorena Chávez Caraza, Adrián Marcelo González Gil, Jaime Javier Cantú Pompa, Edgar Moreno Medrano, Luis Alonso Morales-Garza
BACKGROUND: Hydrogen breath tests (HBT) are used to confirm the diagnosis of carbohydrate intolerance or small intestinal bacterial overgrowth (SIBO). OBJECTIVE: Determine the existence of a correlation between the presence and intensity of symptoms experimented by the patient after the ingestion of a carbohydrate load and the test result. MATERIALS AND METHODS: This is an observational, retrospective and analytic study, in which all patients' files from year 2008 to 2014 containing a report of a HBT performed at Hospital San José TEC de Monterrey were revised...
July 2016: Revista de Gastroenterología del Perú: órgano Oficial de la Sociedad de Gastroenterología del Perú
https://www.readbyqxmd.com/read/27714695/regulation-of-oligodendrocyte-differentiation-and-myelination-by-nuclear-receptors-role-in-neurodegenerative-disorders
#16
Adrián Sandoval-Hernández, María José Contreras, Jenny Jaramillo, Gonzalo Arboleda
During development and through adulthood, differentiation of diverse cell types is controlled by specific genetic and molecular programs for which transcription factors are master regulators of gene expression. Here, we present an overview of the role of nuclear receptors and their selective pharmacological modulators in oligodendrocytes linage, their role in myelination and remyelination and their potential use as a therapeutic strategy for demyelinating diseases. We discuss several aspects of nuclear receptors including: (1) the biochemistry of nuclear receptors superfamily; (2) their role on stem cells physiology, focusing in differentiation and cell removal; (3) the role of nuclear receptor in the oligodendrocytes cell linage, from oligodendrocyte progenitors cells to mature myelinating cells; and (4) the therapeutics opportunities of nuclear receptors for specific demyelinating diseases...
2016: Advances in Experimental Medicine and Biology
https://www.readbyqxmd.com/read/27704799/post-gold-king-mine-spill-investigation-of-metal-stability-in-water-and-sediments-of-the-animas-river-watershed
#17
Lucia Rodriguez-Freire, Sumant M Avasarala, Abdul-Mehdi S Ali, Diane Agnew, Joseph H Hoover, Kateryna Artyushkova, Drew E Latta, Eric John Peterson, Johnnye Lewis, Laura J Crossey, Adrian J Brearley, Jose M Cerrato
We applied spectroscopy, microscopy, diffraction, and aqueous chemistry methods to investigate the persistence of metals in water and sediments from the Animas River 13 days after the Gold King Mine spill (August 5, 2015). The Upper Animas River watershed, located in San Juan CO, is heavily mineralized and impacted by acid mine drainage, with low pH water and elevated metal concentrations in sediments (108.4±1.8 mg kg(-1) Pb, 32.4±0.5 mg kg(-1) Cu, 729.6±5.7 mg kg(-1) Zn and 51,314.6±295.4 mg kg(-1) Fe)...
October 5, 2016: Environmental Science & Technology
https://www.readbyqxmd.com/read/27690702/clinical-management-of-community-acquired-pneumonia-in-the-elderly-patient
#18
Catia Cilloniz, Adrian Ceccato, Alicia San Jose, Antoni Torres
Community acquired pneumonia (CAP) is a major health problem in elderly persons and is associated with high morbidity and mortality. Areas covered: This article reviews the most recent publications relative to CAP in the elderly population, with a focus on epidemiology, prognostic factors, microbial etiology, therapy and prevention. The data discussed in this review were mainly obtained from a non-systematic review using Medline, and references from relevant articles. Expert Commentary: CAP can occur at any age, but its incidence and risk of death are linked to increasing age...
October 3, 2016: Expert Review of Respiratory Medicine
https://www.readbyqxmd.com/read/27688904/c1q-assay-results-in-complement-dependent-cytotoxicity-crossmatch-negative-renal-transplant-candidates-with-donor-specific-antibodies-high-specificity-but-low-sensitivity-when-predicting-flow-crossmatch
#19
José M Arreola-Guerra, Natalia Castelán, Adrián de Santiago, Adriana Arvizu, Norma Gonzalez-Tableros, Mayra López, Isaac Salcedo, Mario Vilatobá, Julio Granados, Luis E Morales-Buenrostro, Josefina Alberú
The aim of the present study was to describe the association of positive flow cross match (FXM) and C1q-SAB. Methods. In this observational, cross-sectional, and comparative study, patients included had negative AHG-CDC-XM and donor specific antibodies (DSA) and were tested with FXM. All pretransplant sera were tested with C1q-SAB assay. Results. A total of 50 donor/recipient evaluations were conducted; half of them had at least one C1q+ Ab (n = 26, 52%). Ten patients (20.0%) had DSA C1q+ Ab. Twenty-five (50%) FXMs were positive...
2016: Journal of Transplantation
https://www.readbyqxmd.com/read/27677649/identification-of-aminopyrimidine-sulfonamides-as-potent-modulators-of-wag31-mediated-cell-elongation-in-mycobacteria
#20
Vinayak Singh, Neeraj Dhar, János Pató, Gaëlle S Kolly, Jana Korduláková, Martin Forbak, Joanna C Evans, Rita Székely, Jan Rybniker, Zuzana Palčeková, Júlia Zemanová, Isabella Santi, François Signorino-Gelo, Liliana Rodrigues, Anthony Vocat, Adrian S Covarrubias, Monica G Rengifo, Kai Johnsson, Sherry Mowbray, Joseph Buechler, Vincent Delorme, Priscille Brodin, Graham W Knott, José A Aínsa, Digby F Warner, György Kéri, Katarína Mikušová, John D McKinney, Stewart T Cole, Valerie Mizrahi, Ruben C Hartkoorn
There is an urgent need to discover new anti-tubercular agents with novel mechanisms of action in order to tackle the scourge of drug-resistant tuberculosis. Here, we report the identification of such a molecule - an AminoPYrimidine-Sulfonamide (APYS1) that has potent, bactericidal activity against M. tuberculosis. Mutations in APYS1-resistant M. tuberculosis mapped exclusively to wag31, a gene that encodes a scaffolding protein thought to orchestrate cell elongation. Recombineering confirmed that a Gln201Arg mutation in Wag31 was sufficient to cause resistance to APYS1, however, neither overexpression nor conditional depletion of wag31 impacted M...
September 28, 2016: Molecular Microbiology
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