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Leonardo Roever, Elmiro Santos Resende, Angélica Lemos Debs Diniz, Nilson Penha-Silva, João Lucas O'Connell, Paulo Fernando Silva Gomes, Hugo Ribeiro Zanetti, Anaisa Silva Roerver-Borges, Fernando César Veloso, Fernanda Rodrigues de Souza, Poliana Rodrigues Alves Duarte, Thiago Montes Fidale, Antonio Casella-Filho, Paulo Magno Martins Dourado, Antonio Carlos Palandri Chagas, Sadeq Ali-Hasan-Al-Saegh, Paulo Eduardo Ocke Reis, Rogério de Melo Costa Pinto, Gustavo B F Oliveira, Álvaro Avezum, Mansueto Neto, André Rodrigues Durães, Rose Mary Ferreira Lisboa da Silva, Antonio José Grande, Celise Denardi, Renato Delascio Lopes, Nitesh Nerlekar, Shahab Alizadeh, Adrian V Hernandez, Maria Inês da Rosa, Giuseppe Biondi-Zoccai
INTRODUCTION: The prevalence of metabolic syndrome (MetS) and MetS-related stroke is set to increase dramatically in coming decades. MetS is a complex disease that includes endothelial dysfunction, insulin resistance, diabetes, hypertension, ectopic obesity, and dyslipidaemia and an increased risk of cardiovascular events. One function of high-density lipoprotein (HDL) cholesterol (HDL-C) is the cholesterol-efflux pathway, which is the pathway where cholesterol is removed from macrophages within the arterial walls back into the bloodstream and out to the liver...
June 2018: Medicine (Baltimore)
Ugur Ozturk, Dadiyorto Wendi, Irene Crisologo, Adrian Riemer, Ankit Agarwal, Kristin Vogel, José Andrés López-Tarazón, Oliver Korup
Flash floods and debris flows are iconic hazards in mountainous regions with steep relief, high rainfall intensities, rapid snowmelt events, and abundant sediments. The cuesta landscapes of southern Germany hardly come to mind when dealing with such hazards. A series of heavy rainstorms dumping up to 140 mm in 2 h caused destructive flash floods and debris flows in May 2016. The most severe damage occurred in the Braunsbach municipality, which was partly buried by 42,000 m3 of boulders, gravel, mud, and anthropogenic debris from the small catchment of Orlacher Bach (~6 km2 )...
June 1, 2018: Science of the Total Environment
José Edgardo Dipierri, Rubén Adrian Bronberg
Debido al incremento de casos de microcefalia por virus Zika en Brasil el Ministerio de Salud de Argentina recomienda incrementar la vigilancia de esta malformación. A fin de profundizar el conocimiento del comportamiento epidemiológico de microcefalia en el país se analiza la mortalidad infantil por microcefalia entre 1998-2012. Los datos proceden de la Dirección de Estadísticas e Información de Salud (DEIS). Se calculó por provincias y regiones la tasa de mortalidad infantil por microcefalia (TMI-M) y se realizó un análisis de agrupamiento a nivel departamental...
September 8, 2017: Revista de la Facultad de Ciencias Médicas
Alan G Contreras, Aurora Casillas-Abundis, Josefina Alberú, Luis Llorente, Guadalupe Lima, Adriana Arvizu, Adrián de Santiago, Mario Vilatobá, Julio Granados, Luis E Morales-Buenrostro, Rodrigo Cruz, José M Arreola-Guerra
The aim of this study is to compare the association and the predictive capacity of DSA MFI, complement fixing capacity (C3d assay) and IgG subclasses determination in the prediction of FCxM result. METHODS: We used cryopreserved (70C) sera from potential renal transplant recipients, containing DSA against their respective potential donors. All patients showed negative AHG-CDC CxM and either positive or negative FCxM. Class I and Class II HLA-DSA were determined by Luminex SAB. C3d were detected by luminex (Lifecodes®Immucor), DSA IgG 1-4 subclasses were evaluated using monoclonal antibodies specific for IgG subclasses (Luminex)...
June 6, 2018: Transplant Immunology
Adrián Macho-González, Alba Garcimartín, Feras Naes, María Elvira López-Oliva, Ángela Amores-Arrojo, Maria Jose Gonzales-Muñoz, Sara Bastida, Juana Benedi, Francisco J Sanchez-Muniz
Increased postprandial lipemia is a cardiovascular disease (CVD) risk factor. Carob fruit extract (CFE) contains condensed tannins whose intake has been inversely related to CVD. The objective was to evaluate the in vitro pancreatic lipase activity in presence of CFE and the in vivo effect of CFE on postprandial lipemia of healthy Wistar rats in acute and subchronic digestibility studies, and to relate it with changes in fat digestion and absorption. CFE significantly reduced pancreatic lipase activity. A peak delay and a dose-dependent decrease of plasma triglyceride and cholesterol areas-under-the-curve were observed, effects that were increased after the subchronic treatment...
June 7, 2018: Journal of Agricultural and Food Chemistry
Antonio Arnaiz-Villena, Ignacio Juarez, Jose Palacio-Gruber, Ester Muñiz, Cristina Campos, Jorge Martinez-Laso, Jorge Nieto, Adrian Lopez-Nares, Jose Manuel Martin-Villa, Carlos Silvera
Original San Basilio de Palenque population (North Colombia) fled from Spanish traders that carried them as slaves and they funded in nearby Maria mountains a fortified town (Palenque). They started helping new Africans brought as slaves to flee and join them. Most of them spoke a Bantu-Congo language and nowadays they speak the only one extant Bantu-Spanish Creole language. Spanish Crown were forced to issue a decree declaring them free (1691 AD), more than 100 years before than Haiti Republic existed. HLA-A, -B, -DRB1 and -DQB1 alleles were studied and further computer procedures were performed with Arlequin 3...
June 1, 2018: Human Immunology
Andrea K Wittenborn, Adrian J Blow, Kendal Holtrop, José R Parra-Cardona
There is a critical need for high-quality and accessible treatments to improve mental health. Yet, there are indications that the research being conducted by contemporary marriage and family therapy (MFT) scholars focuses less on advancing and disseminating clinical interventions than in previous decades. In this article, we describe challenges to increasing rigorous clinical research in MFT. We use systems mapping and the intervention-level framework to identify strategic goals designed to drive innovation in clinical research in the field...
June 4, 2018: Journal of Marital and Family Therapy
Alexandra González Aguña, Virginia Díaz Teruel, Adrián Satamaría Pérez, Jorge Luis Gómez González, Ma Lourdes Jiménez Rodríguez, José Ma Santamaría García, Sylvia Claudine Ramírez Sánchez, Niurka Vialart Vidal, Daniel Flavio Condor Camara
The diagnosis of care problems is a complex process that involves many variables and inferences. This competence begins to acquire during the student stage, but matures later. The qualified professional continues to settle and perfect this judgment ability. Expert Systems are technologies that can help in making decisions such as diagnosis. The objective of this study is to build an Expert System in order to help in diagnosis of care problems by means of taxonomic triangulation technique. The deductive method follows three phases that result in the representation of expert knowledge through an associative network, the construction of a verified and validated prototype and, finally, the design of an app through a document of requirements specification in IEEE standard...
2018: Studies in Health Technology and Informatics
Adrián Canizalez-Román, Abraham Campos-Romero, José A Castro-Sánchez, Mario A López-Martínez, Francisco J Andrade-Muñoz, Cinthia K Cruz-Zamudio, Tania G Ortíz-Espinoza, Nidia León-Sicairos, Alma M Gaudrón Llanos, Jorge Velázquez-Román, Héctor Flores-Villaseñor, Secundino Muro-Amador, Jesús J Martínez-García, Jonathan Alcántar-Fernández
Objective: To determine the frequency and distribution of ABO and Rh (D) antigens and, additionally, investigate gene diversity and the structure of Mexican populations. Materials and Methods: Blood groups were tested in 271,164 subjects from 2014 to 2016. The ABO blood group was determined by agglutination using the antibodies anti-A, Anti-B, and Anti-D for the Rh factor, respectively. Results: The overall distribution of ABO and Rh (D) groups in the population studied was as follows: O: 61...
2018: BioMed Research International
David A Wolk, Carl Sadowsky, Beth Safirstein, Juha O Rinne, Ranjan Duara, Richard Perry, Marc Agronin, Jose Gamez, Jiong Shi, Adrian Ivanoiu, Lennart Minthon, Zuzana Walker, Steen Hasselbalch, Clive Holmes, Marwan Sabbagh, Marilyn Albert, Adam Fleisher, Paul Loughlin, Eric Triau, Kirk Frey, Peter Høgh, Andrea Bozoki, Roger Bullock, Eric Salmon, Gillian Farrar, Christopher J Buckley, Michelle Zanette, Paul F Sherwin, Andrea Cherubini, Fraser Inglis
Importance: Patients with amnestic mild cognitive impairment (aMCI) may progress to clinical Alzheimer disease (AD), remain stable, or revert to normal. Earlier progression to AD among patients who were β-amyloid positive vs those who were β-amyloid negative has been previously observed. Current research now accepts that a combination of biomarkers could provide greater refinement in the assessment of risk for clinical progression. Objective: To evaluate the ability of flutemetamol F 18 and other biomarkers to assess the risk of progression from aMCI to probable AD...
May 14, 2018: JAMA Neurology
Juan Fernando Sánchez Vega, Magdali Del Rocío Murillo Bacilio, Adrián Santiago Vintimilla Condoy, Araceli Miroslava Palta González, José Alfredo Crespo Astudillo, Franklin Geovany Mora-Bravo
BACKGROUND: Cancer antigen (CA) 125 (CA-125) is used in ovarian cancer detection and monitoring, whose serum level has a positive correlation with tumor stage. The aim of this study was to obtain a prediction metastasis equation in a group of patients with ovarian cancer based on Ca-125. METHODS: A 2-group comparative observational study was conducted at a single oncologic institution (SOLCA) in Cuenca-Ecuador. All patients who were diagnosed with ovarian cancer between January 1996 and December 2016 were included in the current study...
May 24, 2018: BMC Cancer
Juan Ambrosioni, Adrian Tellez, Marta Hernandez-Meneses, Jaume Llopis, Asuncion Moreno, José M Miró
No abstract text is available yet for this article.
May 21, 2018: Clinical Infectious Diseases: An Official Publication of the Infectious Diseases Society of America
Alejandro Sanz-Bravo, Adrian Martin-Esteban, Jonas J W Kuiper, Marina García-Peydró, Eilon Barnea, Arie Admon, José A López de Castro
Virtually all patients of the rare inflammatory eye disease birdshot chorioretinopathy (BSCR) carry the HLA-A*29:02 allele. BSCR is also associated with endoplasmic reticulum aminopeptidase 2 (ERAP2), an enzyme involved in processing HLA class I ligands, thus implicating the A*29:02 peptidome in this disease. To investigate the relationship between both risk factors we employed label-free quantitative mass spectrometry to characterize the effects of ERAP2 on the A*29:02-bound peptidome. An ERAP2-negative cell line was transduced with lentiviral constructs containing GFP-ERAP2 or GFP alone, and the A*29:02 peptidomes from both transduced cells were compared...
May 16, 2018: Molecular & Cellular Proteomics: MCP
Pietro Fratta, Prasanth Sivakumar, Jack Humphrey, Kitty Lo, Thomas Ricketts, Hugo Oliveira, Jose M Brito-Armas, Bernadett Kalmar, Agnieszka Ule, Yichao Yu, Nicol Birsa, Cristian Bodo, Toby Collins, Alexander E Conicella, Alan Mejia Maza, Alessandro Marrero-Gagliardi, Michelle Stewart, Joffrey Mianne, Silvia Corrochano, Warren Emmett, Gemma Codner, Michael Groves, Ryutaro Fukumura, Yoichi Gondo, Mark Lythgoe, Erwin Pauws, Emma Peskett, Philip Stanier, Lydia Teboul, Martina Hallegger, Andrea Calvo, Adriano Chiò, Adrian M Isaacs, Nicolas L Fawzi, Eric Wang, David E Housman, Francisco Baralle, Linda Greensmith, Emanuele Buratti, Vincent Plagnol, Elizabeth Mc Fisher, Abraham Acevedo-Arozena
TDP-43 (encoded by the gene TARDBP ) is an RNA binding protein central to the pathogenesis of amyotrophic lateral sclerosis (ALS). However, how TARDBP mutations trigger pathogenesis remains unknown. Here, we use novel mouse mutants carrying point mutations in endogenous Tardbp to dissect TDP-43 function at physiological levels both in vitro and in vivo Interestingly, we find that mutations within the C-terminal domain of TDP-43 lead to a gain of splicing function. Using two different strains, we are able to separate TDP-43 loss- and gain-of-function effects...
May 15, 2018: EMBO Journal
Moisés Rodríguez-Mañero, Estrella López-Pardo, Alberto Cordero, Omar Kreidieh, José Novo Platas, Luis Valdés, Adrian Cid-Menendez, Javier García-Seara, María Pereira-Vázquez, Jose-Luis Martínez-Sande, Alberto Ruano, Carlos Peña-Gil, Pilar Mazón, Jose María García-Acuña, José Ramón González-Juanatey
INTRODUCTION: Atrial fibrillation might increase the risk of dementia. We aim to test the hypothesis that dementia could reclassify the actual risk of stroke and death predicted by the CHA2DS2-VASc in patients with atrial fibrillation (AF). METHODS: A prospective study performed in a specific health care area. RESULTS: From our health care area (n = 348,985), throughout 2013, AF was codified in 7,990 (2.08%). Mean age was 76.83 ± 10.5, mean CHA2DS2-VASc = 3...
May 15, 2018: Neuroepidemiology
Cristian Adrián Márquez-Ramírez, José Lucio Hernández de la Paz, Omar Ortiz-Avila, Andrés Raya-Farias, Juan Carlos González-Hernández, Alain Raimundo Rodríguez-Orozco, Rafael Salgado-Garciglia, Alfredo Saavedra-Molina, Daniel Godínez-Hernández, Christian Cortés-Rojo
OBJECTIVE: Angiotensin II (Ang-II) antagonism alleviates hypertensive kidney damage by improving mitochondrial function and decreasing oxidative stress. This condition also is associated with altered renal vascular tone due to enhanced constriction by Ang-II. Thus, approaches ameliorating these events are desirable to alleviate kidney damage. Avocado oil, a source of antioxidants and oleic acid, is known to improve mitochondrial function, while oleic acid has antihypertensive effects...
March 20, 2018: Nutrition
Dan Ionuţ Cosma, Andrei Corbu, Dan Viorel Nistor, Adrian Todor, Madalina Valeanu, Jose Morcuende, Sorin Man
PURPOSE: The aim of the study was to evaluate the role of joint hyperlaxity (by Beighton score) as a protective factor for clubfoot relapse. METHODS: Patients with idiopathic clubfoot treated with the Ponseti method between January 2004 and December 2012, without other congenital foot deformity, and not previously treated by open surgery were included in either the Relapse group (n = 23) if it was a clubfoot relapse or the Control group (n = 19) if no relapse was noted...
May 7, 2018: International Orthopaedics
Adrian Israel Martinez-Franco, Melchor Sanchez-Mendiola, Juan Jose Mazon-Ramirez, Isaias Hernandez-Torres, Carlos Rivero-Lopez, Troy Spicer, Adrian Martinez-Gonzalez
BACKGROUND: Clinical reasoning is an essential skill in physicians, required to address the challenges of accurate patient diagnoses. The goal of the study was to compare the diagnostic accuracy in Family Medicine residents, with and without the use of a clinical decision support tool (DXplain METHODS: A total of 87 first-year Family Medicine residents, training at the National Autonomous University of Mexico (UNAM) Postgraduate Studies Division in Mexico City, participated voluntarily in the study...
May 7, 2018: Diagnosis
Laura Vian, Aleksandra Pękowska, Suhas S P Rao, Kyong-Rim Kieffer-Kwon, Seolkyoung Jung, Laura Baranello, Su-Chen Huang, Laila El Khattabi, Marei Dose, Nathanael Pruett, Adrian L Sanborn, Andres Canela, Yaakov Maman, Anna Oksanen, Wolfgang Resch, Xingwang Li, Byoungkoo Lee, Alexander L Kovalchuk, Zhonghui Tang, Steevenson Nelson, Michele Di Pierro, Ryan R Cheng, Ido Machol, Brian Glenn St Hilaire, Neva C Durand, Muhammad S Shamim, Elena K Stamenova, José N Onuchic, Yijun Ruan, Andre Nussenzweig, David Levens, Erez Lieberman Aiden, Rafael Casellas
Cohesin extrusion is thought to play a central role in establishing the architecture of mammalian genomes. However, extrusion has not been visualized in vivo, and thus, its functional impact and energetics are unknown. Using ultra-deep Hi-C, we show that loop domains form by a process that requires cohesin ATPases. Once formed, however, loops and compartments are maintained for hours without energy input. Strikingly, without ATP, we observe the emergence of hundreds of CTCF-independent loops that link regulatory DNA...
May 17, 2018: Cell
Emiy Yokoyama, Margarita Chávez-Saldaña, Lorena Orozco, Francisco Cuevas, José Luis Lezana, Rosa María Vigueras-Villaseñor, Julio Cesar Rojas-Castañeda, Daniel Adrian Landero
BACKGROUND: The variation in cystic fibrosis (CF) lung disease not always is explained by the CFTR genotype, so it has become apparent that modifier genes must play a considerable role in the phenotypic heterogeneity of CF, so we investigated the association of allelic variants in modifier genes that modulate the severity of lung function in a group of Mexican patients diagnosed with CF. METHODS: We included 140 CF patients classified according to lung phenotype and analyzed 17 single nucleotide polymorphisms (SNPs) by TaqMan® allelic discrimination...
April 24, 2018: Archives of Medical Research
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