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https://www.readbyqxmd.com/read/28938110/monitoring-harm-perceptions-of-smokeless-tobacco-products-among-u-s-adults-health-information-national-trends-survey-2012-2014-2015
#1
Shari P Feirman, Elisabeth A Donaldson, Mark Parascandola, Kimberly Snyder, Cindy Tworek
INTRODUCTION: Changes to the U.S. smokeless tobacco landscape in recent years include a change to health warnings on packages, the implementation of bans in some stadiums, and the launch of a federal youth prevention campaign. It is unclear whether such changes have impacted consumer beliefs about smokeless tobacco. This study examines relative harm perceptions of smokeless tobacco compared to cigarettes among adults and assesses changes in smokeless tobacco harm perceptions over time...
September 9, 2017: Addictive Behaviors
https://www.readbyqxmd.com/read/28938012/f-map-a-bayesian-approach-to-infer-the-gene-regulatory-network-using-external-hints
#2
Maryam Shahdoust, Hamid Pezeshk, Hossein Mahjub, Mehdi Sadeghi
The Common topological features of related species gene regulatory networks suggest reconstruction of the network of one species by using the further information from gene expressions profile of related species. We present an algorithm to reconstruct the gene regulatory network named; F-MAP, which applies the knowledge about gene interactions from related species. Our algorithm sets a Bayesian framework to estimate the precision matrix of one species microarray gene expressions dataset to infer the Gaussian Graphical model of the network...
2017: PloS One
https://www.readbyqxmd.com/read/28937300/infants-processing-of-prosodic-cues-electrophysiological-evidence-for-boundary-perception-beyond-pause-detection
#3
Julia Holzgrefe-Lang, Caroline Wellmann, Barbara Höhle, Isabell Wartenburger
Infants as young as six months are sensitive to prosodic phrase boundaries marked by three acoustic cues: pitch change, final lengthening, and pause. Behavioral studies suggest that a language-specific weighting of these cues develops during the first year of life; recent work on German revealed that eight-month-olds, unlike six-month-olds, are capable of perceiving a prosodic boundary on the basis of pitch change and final lengthening only. The present study uses Event-Related Potentials (ERPs) to investigate the neuro-cognitive development of prosodic cue perception in German-learning infants...
September 1, 2017: Language and Speech
https://www.readbyqxmd.com/read/28936025/swelling-of-latex-particles-towards-a-solution-of-the-riddle
#4
Amit Tripathi, Chunxiang Wei, Klaus Tauer
The assumption that during emulsion polymerization, the monomer molecules simply diffuse through the aqueous phase into the latex particles is a commonplace. However, there are experimental hints that this might not be that easy. Here, simulation results are discussed based on Fick's diffusion laws regarding the swelling of latex particles. The results of quantitative application of these laws for swelling of latex particles allow the conclusion that the instantaneous replenishment of the consumed monomer during emulsion polymerization requires a close contact between the monomer and the polymer particles...
2017: Colloid and Polymer Science
https://www.readbyqxmd.com/read/28935773/a-randomized-double-blinded-phase-ii-trial-of-gemcitabine-and-nab-paclitaxel-plus-apatorsen-or-placebo-in-patients-with-metastatic-pancreatic-cancer-the-rainier-trial
#5
Andrew H Ko, Patrick B Murphy, James D Peyton, Dianna L Shipley, Ahmed Al-Hazzouri, Francisco A Rodriguez, Mark S Womack, Henry Q Xiong, David M Waterhouse, Margaret A Tempero, Shuangli Guo, Cassie M Lane, Chris Earwood, Laura M DeBusk, Johanna C Bendell
LESSONS LEARNED: The addition of the heat shock protein 27 (Hsp27)-targeting antisense oligonucleotide, apatorsen, to a standard first-line chemotherapy regimen did not result in improved survival in unselected patients with metastatic pancreatic cancer.Findings from this trial hint at the possible prognostic and predictive value of serum Hsp27 that may warrant further investigation. BACKGROUND: This randomized, double-blinded, phase II trial evaluated the efficacy of gemcitabine/nab-paclitaxel plus either apatorsen, an antisense oligonucleotide targeting heat shock protein 27 (Hsp27) mRNA, or placebo in patients with metastatic pancreatic cancer...
September 21, 2017: Oncologist
https://www.readbyqxmd.com/read/28934807/development-of-report-turnaround-times-in-a-university-department-of-radiology-during-implementation-of-a-reformed-curriculum-for-undergraduate-medical-education
#6
Liane Albrecht, Martin H Maurer, Tim Seithe, Joachim Braun, Richard Gummert, Jonas Auer, Keno Sponheuer, Tobias Philipp Meyl, Bernd Hamm, Maximilian de Bucourt
Purpose The implementation of a reformed curriculum for undergraduate medical education with a problem-oriented focus and more bedside teaching in small groups increases the academic teaching workload. The aim of this study was to investigate whether this increase in teaching duties is associated with an increase in report turnaround times of radiologists or increased unplanned absence during term times compared with term breaks (lecture-free periods) and over the whole period under investigation. Materials and Methods The database of all radiological examinations performed at a large German university hospital was retrospectively analyzed for a two-year period from the winter term 2011/12 to the summer term 2013...
September 21, 2017: RöFo: Fortschritte Auf Dem Gebiete der Röntgenstrahlen und der Nuklearmedizin
https://www.readbyqxmd.com/read/28934750/frontotemporal-dementia-caused-by-the-p301l-mutation-in-the-mapt-gene-clinicopathological-features-of-13-cases-from-the-same-geographical-origin-in-barcelona-spain
#7
Sergi Borrego-Écija, Joana Morgado, Leire Palencia-Madrid, Oriol Grau-Rivera, Ramón Reñé, Isabel Hernández, Consuelo Almenar, Mircea Balasa, Anna Antonell, José Luis Molinuevo, Albert Lladó, Marian Martínez de Pancorbo, Ellen Gelpi, Raquel Sánchez-Valle
BACKGROUND/AIMS: We identified and studied 13 patients carrying the P301L mutation in the MAPT gene from the same area (Baix Llobregat County) in Barcelona, Spain. METHODS: The demographic and clinical features were reviewed retrospectively. Detailed neuropathological characterization was obtained in 9 subjects. To investigate the origin of the P301L mutation in these families, 20 single nucleotide polymorphisms (SNPs) in the MAPT gene were analyzed. RESULTS: The mean age at disease onset was 51 years and the mean disease duration was 7 years...
September 22, 2017: Dementia and Geriatric Cognitive Disorders
https://www.readbyqxmd.com/read/28934526/mechanisms-of-memory-retrieval-in-slow-wave-sleep
#8
Scott A Cairney, Justyna M Sobczak, Shane Lindsay, M Gareth Gaskell
Study Objectives: Memories are strengthened during sleep. The benefits of sleep for memory can be enhanced by re-exposing the sleeping brain to auditory cues; a technique known as targeted memory reactivation (TMR). Prior studies have not assessed the nature of the retrieval mechanisms underpinning TMR: the matching process between auditory stimuli encountered during sleep and previously encoded memories. We carried out two experiments to address this issue. Methods: In Experiment 1, participants associated words with verbal and nonverbal auditory stimuli before an overnight interval in which subsets of these stimuli were replayed in slow-wave sleep...
September 1, 2017: Sleep
https://www.readbyqxmd.com/read/28934400/genomic-characterisation-of-environmental-pseudomonas-aeruginosa-isolated-from-dental-unit-waterlines-revealed-the-insertion-sequence-ispa11-as-a-chaotropic-element
#9
Antony T Vincent, Luca Freschi, Julie Jeukens, Irena Kukavica-Ibrulj, Jean-Guillaume Emond-Rheault, Annie Leduc, Brian Boyle, Fabrice Jean-Pierre, Marie-Christine Groleau, Eric Déziel, Jean Barbeau, Steve J Charette, Roger C Levesque
The bacterium Pseudomonas aeruginosa is well known to have a remarkable adaptive capacity allowing it to colonise many environments. A recent study on environmental isolates from dental unit waterlines (DUWLs) hinted at a genetic clustering into two groups. Isolates from one of these groups, named cluster III, were shown to have unusual phenotypes for environmental isolates, such as an increased biofilm production. To have a better ecological view, more specifically on isolates from cluster III, the complete genomes of 39 isolates including 16 from DUWLs were sequenced...
September 1, 2017: FEMS Microbiology Ecology
https://www.readbyqxmd.com/read/28934229/above-and-below-ground-carbohydrate-allocation-differs-between-ash-fraxinus-excelsior-l-and-beech-fagus-sylvatica-l
#10
Ronny Thoms, Michael Köhler, Arthur Gessler, Gerd Gleixner
We investigated soluble carbohydrate transport in trees that differed in their phloem loading strategies in order to better understand the transport of photosynthetic products into the roots and the rhizosphere as this knowledge is needed to better understand the respiratory processes in the rhizosphere. We compared beech, which is suggested to use mainly passive loading of transport sugars along a concentration gradient into the phloem, with ash that uses active loading and polymer trapping of raffinose family oligosaccharides (RFOs)...
2017: PloS One
https://www.readbyqxmd.com/read/28930230/angelica-sinensis-oliv-diels-influence-of-value-chain-on-quality-criteria-and-marker-compounds-ferulic-acid-and-z-ligustilide
#11
Nino Giacomelli, Yang Yongping, Franz K Huber, Anita Ankli, Caroline S Weckerle
Background:Dang gui (Apiaceae; Angelica sinensis radix) is among the most often used Chinese medicinal plants. However, hardly anything is known about its value chain and its influence on the main marker compounds of the drug. The aim of this study is to investigate the value chain of dang gui in Gansu and Yunnan, and the analysis of the marker compounds ferulic acid and Z-ligustilide concentration in relation to quality criteria such as the production area and size of the roots. Methods: During six months of field research in China, semi-structured interviews with various stakeholders of the value chain were undertaken and plant material was collected...
March 14, 2017: Medicines (Basel, Switzerland)
https://www.readbyqxmd.com/read/28929194/adapting-secretory-proteostasis-and-function-through-the-unfolded-protein-response
#12
Madeline Y Wong, Andrew S DiChiara, Patreece H Suen, Kenny Chen, Ngoc-Duc Doan, Matthew D Shoulders
Cells address challenges to protein folding in the secretory pathway by engaging endoplasmic reticulum (ER)-localized protective mechanisms that are collectively termed the unfolded protein response (UPR). By the action of the transmembrane signal transducers IRE1, PERK, and ATF6, the UPR induces networks of genes whose products alleviate the burden of protein misfolding. The UPR also plays instructive roles in cell differentiation and development, aids in the response to pathogens, and coordinates the output of professional secretory cells...
September 20, 2017: Current Topics in Microbiology and Immunology
https://www.readbyqxmd.com/read/28926251/correction-to-theoretical-study-on-the-acidities-of-chiral-phosphoric-acids-in-dimethyl-sulfoxide-hints-for-organocatalysis
#13
Chen Yang, Xiao-Song Xue, Jia-Lu Jin, Xin Li, Jin-Pei Cheng
No abstract text is available yet for this article.
September 19, 2017: Journal of Organic Chemistry
https://www.readbyqxmd.com/read/28923128/-items-for-criticism-not-in-sequence-joseph-delee-pare-lorentz-and-the-fight-for-life-1940
#14
Caitjan Gainty
In the late 1920s, the American obstetrician Joseph DeLee brought the motion-picture camera into the birth room. Following that era's trend of adapting industrial efficiency practices for medical environments, DeLee's films give spectacular and unexpected expression to the engineering concept of 'streamlining'. Accomplishing what more tangible obstetric streamlining practices had failed to, DeLee's cameras, and his post-production manipulation, shifted birth from messy and dangerous to rationalized, efficient, death-defying...
September 2017: British Journal for the History of Science
https://www.readbyqxmd.com/read/28922730/long-non-coding-rna-pcat-1-contributes-to-tumorigenesis-by-regulating-fscn1-via-mir-145-5p-in-prostate-cancer
#15
Weibo Xu, Junkai Chang, Xinyi Du, Junqing Hou
Prostate cancer associated lncRNA transcript 1 (PCAT-1) has been identified as an oncogenic long non-coding RNA (lncRNA) in some solid tumors, including prostate cancer (PC). However, the molecular mechanism of PCAT-1 involved in PC is poorly defined. In this study, we found that PCAT-1 expression was up-regulated and miR-145-5p expression was down-regulated in PC tissues and cells. Function analysis indicated that PCAT-1 overexpression promoted proliferation, migration, invasion and inhibited apoptosis of PC cells...
September 14, 2017: Biomedicine & Pharmacotherapy, Biomédecine & Pharmacothérapie
https://www.readbyqxmd.com/read/28920665/kinetic-and-thermodynamic-control-of-structure-transformations-in-a-family-of-cobalt-ii-organic-frameworks
#16
Qiang Chen, Rui Feng, Jian Xu, Yan-Yuan Jia, Ting-Ting Wang, Ze Chang, Xian-He Bu
Dynamic metal-organic frameworks (MOFs) that respond to external stimuli have recently attracted great attention. However, the subtle control of dynamical processes as well as the illustration of the underlying mechanism, which is crucial for the targeted construction and modulation propose, is extremely challenging. Herein, we report the achievement of simultaneous kinetic and thermodynamic modulation of the structure transformation processes of a family of cobalt(II)-organic frameworks, through the rational combination of co-ligand replacement, solvent molecule substitution and ligand-based solid solution strategies...
September 18, 2017: ACS Applied Materials & Interfaces
https://www.readbyqxmd.com/read/28918554/genome-wide-identification-classification-evolutionary-analysis-and-gene-expression-patterns-of-the-protein-kinase-gene-family-in-wheat-and-aegilops-tauschii
#17
Jun Yan, Peisen Su, Zhaoran Wei, Eviatar Nevo, Lingrang Kong
In this study we systematically identified and classified PKs in Triticum aestivum, Triticum urartu and Aegilops tauschii. Domain distribution and exon-intron structure analyses of PKs were performed, and we found conserved exon-intron structures within the exon phases in the kinase domain. Collinearity events were determined, and we identified various T. aestivum PKs from polyploidizations and tandem duplication events. Global expression pattern analysis of T. aestivum PKs revealed that some PKs might participate in the signaling pathways of stress response and developmental processes...
September 16, 2017: Plant Molecular Biology
https://www.readbyqxmd.com/read/28915661/small-molecular-floribundiquinone-b-derived-from-medicinal-plants-inhibits-acetylcholinesterase-activity
#18
Bing Niu, Mengying Zhang, Pu Du, Li Jiang, Rui Qin, Qiang Su, Fuxue Chen, Dongshu Du, Yilai Shu, Kuo-Chen Chou
Being a neurodegenerative disorder, Alzheimer's disease (AD) is the one of the most terrible diseases. And acetylcholinesterase (AChE) is considered as an important target for treating AD. Acetylcholinesterase inhibitors (AChEI) are considered to be one of the effective drugs for the treatment of AD. The aim of this study is to find a novel potential AChEI as a drug for the treatment of AD. In this study, instead of using the synthetic compounds, we used those extracted from plants to investigate the interaction between floribundiquinone B (FB) and AChE by means of both the experimental approach such as fluorescence spectra, ultraviolet-visible (UV-vis) absorption spectrometry, circular dichroism (CD) and the theoretical approaches such as molecular docking...
August 22, 2017: Oncotarget
https://www.readbyqxmd.com/read/28914204/a-review-on-the-effects-of-testosterone-supplementation-in-hypogonadal-men-with-cognitive-impairment
#19
Mohamad Nur Vaizura, Soelaiman Ima-Nirwana, Kok-Yong Chin
Cognitive function and testosterone level of men decline concurrently with aging. Low testosterone levels are associated with higher risk of Alzheimer's disease and mild cognitive impairment in men. There are continuous debates on whether this relationship is casual or causal. This paper aims to summarize the current evidence on the association between testosterone level and cognitive function in elderly men. The presence of testosterone, androgen receptor and its responsive genes hint that testosterone has biological functions in the central nervous system...
September 13, 2017: Current Drug Targets
https://www.readbyqxmd.com/read/28912007/adventitial-adipogenic-degeneration-is-an-unidentified-contributor-to-aortic-wall-weakening-in-the-abdominal-aortic-aneurysm
#20
Stefan A Doderer, Gabor Gäbel, Vivianne B C Kokje, Bernd H Northoff, Lesca M Holdt, Jaap F Hamming, Jan H N Lindeman
OBJECTIVE: The processes driving human abdominal aortic aneurysm (AAA) progression are not fully understood. Although antiinflammatory and proteolytic strategies effectively quench aneurysm progression in preclinical models, so far all clinical interventions failed. These observations hint at an incomplete understanding of the processes involved in AAA progression and rupture. Interestingly, strong clinical and molecular associations exist between popliteal artery aneurysms (PAAs) and AAAs; however, PAAs have an extremely low propensity to rupture...
September 11, 2017: Journal of Vascular Surgery
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