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https://www.readbyqxmd.com/read/29783084/organochlorine-pesticides-ocps-and-polychlorinated-biphenyls-pcbs-in-cyprinidae-fish-towards-hints-of-their-arrangements-using-advanced-classification-methods
#1
Snježana Herceg Romanić, Gordana Vuković, Darija Klinčić, Marijana Matek Sarić, Ivan Župan, Davor Antanasijević, Aleksandar Popović
To tackle the ever-present global concern regarding human exposure to persistent organic pollutants (POPs) via food products, this study strived to indicate associations between organochlorine pesticides (OCPs) and polychlorinated biphenyls (PCBs) in lake-fish tissue depending on the species and sampling season. Apart from the monitoring initiatives recommended in the Global Monitoring Plan for POPs, the study discussed 7 OCPs and 18 PCB congeners determined in three Cyprinidae species (rudd, carp, and Prussian carp) from Vransko Lake (Croatia), which are widely domesticated and reared as food fish across Europe and Asia...
May 18, 2018: Environmental Research
https://www.readbyqxmd.com/read/29782640/drug-gut-microbiota-interactions-implications-for-neuropharmacology
#2
REVIEW
Jacinta Walsh, Brendan T Griffin, Gerard Clarke, Niall P Hyland
The fate and activity of drugs are frequently dictated not only by the host per se but also by the microorganisms present in the gastrointestinal tract. The gut microbiome is known to, both directly and indirectly, affect drug metabolism. More evidence now hints at the impact that drugs can have on the function and composition of the gut microbiome. Both microbiota-mediated alterations in drug metabolism and drug-mediated alterations in the gut microbiome can have beneficial or detrimental effects on the host...
May 21, 2018: British Journal of Pharmacology
https://www.readbyqxmd.com/read/29778935/different-levels-of-pro-and-anti-inflammatory-cytokines-in-patients-with-unipolar-and-bipolar-depression
#3
Ruizhi Mao, Chen Zhang, Jun Chen, Guoqing Zhao, Rubai Zhou, Fan Wang, Jingjing Xu, Tao Yang, Yousong Su, Jia Huang, Zhiguo Wu, Lan Cao, Yong Wang, Yingyan Hu, Chengmei Yuan, Zhenghui Yi, Wu Hong, Zuowei Wang, Daihui Peng, Yiru Fang
BACKGROUND: Immune system dysregulation is critical in the physiopathology of major depressive disorder (MDD) and bipolar disorder (BD). However, it is unclear whether both diseases present the same inflammatory patterns during depressive episodes. We explored the differences in pro- and anti-inflammatory cytokines between unipolar and bipolar depression (BDD) and the trajectory of these cytokines after acute-phase treatment. METHODS: Sixty-four MDD patients, 61 BDD patients, and 62 healthy controls (HCs) were enrolled...
April 25, 2018: Journal of Affective Disorders
https://www.readbyqxmd.com/read/29777123/synthesis-fungicidal-activity-structure-activity-relationships-sars-and-density-functional-theory-dft-studies-of-novel-strobilurin-analogues-containing-arylpyrazole-rings
#4
Yuanyuan Liu, Kunzhi Lv, Yi Li, Qiuli Nan, Jinyuan Xu
A series of novel strobilurin analogues (1a-1f, 2a-2e, 3a-3e) containing arylpyrazole rings were synthesized and characterized by NMR spectroscopy. The structures of 1f, 2b and 3b were also determined by single crystal X-ray diffraction analysis. These analogues were collected together with other twenty-eight similar compounds 4a-4f, 5a-5h, 6a-6h and 7a-7f from our previous studies, for in vitro bioassays and thorough structure-activity relationships (SARs) studies. Most compounds exhibited excellent-to-good fungicidal activity against Rhizoctonia solani, especially 5c, 7a, 6c, and 3b with 98...
May 18, 2018: Scientific Reports
https://www.readbyqxmd.com/read/29775697/prodrome-and-non-prodrome-phenotypes-of-bladder-pain-syndrome-interstitial-cystitis
#5
John W Warren, Ningbo Jian, Lisa Gallicchio, David Wu, Daniel J Clauw
OBJECTIVE: To test the hypothesis that risk factors for BPS/IC in women differ between those with and without the BPS/IC prodrome. METHODS: Incident cases of BPS/IC and healthy controls were recruited nationally. More than half the BPS/IC cases reported subsyndromal urinary symptoms for decades before onset of BPS/IC and were identified as having the prodrome. Risk factors for BPS/IC were examined separately for cases with and without the prodrome using a set of matched controls...
May 15, 2018: Urology
https://www.readbyqxmd.com/read/29775323/searching-for-new-physics-with-b%C3%A2-s%C3%AF-%C3%AF-processes
#6
Bernat Capdevila, Andreas Crivellin, Sébastien Descotes-Genon, Lars Hofer, Joaquim Matias
In recent years, intriguing hints for the violation of lepton flavor universality (LFU) have been accumulated in semileptonic B decays, both in the charged-current transitions b→cℓ^{-}ν[over ¯]_{ℓ} (i.e., R_{D}, R_{D^{*}}, and R_{J/ψ}) and the neutral-current transitions b→sℓ^{+}ℓ^{-} (i.e., R_{K} and R_{K^{*}}). Hints for LFU violation in R_{D^{(*)}} and R_{J/ψ} point at large deviations from the standard model (SM) in processes involving tau leptons. Moreover, LHCb has reported deviations from the SM expectations in b→sμ^{+}μ^{-} processes as well as in the ratios R_{K} and R_{K^{*}}, which together point at new physics (NP) affecting muons with a high significance...
May 4, 2018: Physical Review Letters
https://www.readbyqxmd.com/read/29774433/dynamic-and-thermodynamic-crossover-scenarios-in-the-kob-andersen-mixture-insights-from-multi-cpu-and-multi-gpu-simulations
#7
Daniele Coslovich, Misaki Ozawa, Walter Kob
The physical behavior of glass-forming liquids presents complex features of both dynamic and thermodynamic nature. Some studies indicate the presence of thermodynamic anomalies and of crossovers in the dynamic properties, but their origin and degree of universality is difficult to assess. Moreover, conventional simulations are barely able to cover the range of temperatures at which these crossovers usually occur. To address these issues, we simulate the Kob-Andersen Lennard-Jones mixture using efficient protocols based on multi-CPU and multi-GPU parallel tempering...
May 17, 2018: European Physical Journal. E, Soft Matter
https://www.readbyqxmd.com/read/29773956/imbalance-p-values-for-baseline-covariates-in-randomized-controlled-trials-a-last-resort-for-the-use-of-p-values-a-pro-and-contra-debate
#8
Andreas Stang, Christopher Baethge
Background: Results of randomized controlled trials (RCTs) are usually accompanied by a table that compares covariates between the study groups at baseline. Sometimes, the investigators report p values for imbalanced covariates. The aim of this debate is to illustrate the pro and contra of the use of these p values in RCTs. Pro: Low p values can be a sign of biased or fraudulent randomization and can be used as a warning sign. They can be considered as a screening tool with low positive-predictive value...
2018: Clinical Epidemiology
https://www.readbyqxmd.com/read/29771509/extzbox-a-glowing-cyclophane-for-live-cell-imaging
#9
Indranil Roy, Sharan Bobbala, Jiawang Zhou, Minh T Nguyen, Siva Krishna Mohan Nalluri, Yilei Wu, Daniel Ferris, Evan Alexander Scott, Michael R Wasielewski, J Fraser Stoddart
The ideal fluorescent probe for live-cell imaging is bright, non-cytotoxic and can be delivered easily into the living cells in an efficient manner. The design of synthetic fluorophores, having all three of these properties, however, has proved to be challenging. Here, we introduce a simple, yet effective, strategy based on well-established chemistry for designing a new class of fluorescent probes for live-cell imaging. A box-like hybrid cyclophane, namely ExTzBox•4X (6•4X, X = PF6 - , Cl- ), has been synthesized by connecting an extended viologen (ExBIPY) and a dipyridyl thiazolothiazole (TzBIPY) unit in an end-to-end fashion with two p-xylylene ( p-Xy) linkers...
May 17, 2018: Journal of the American Chemical Society
https://www.readbyqxmd.com/read/29768483/transport-of-enniatin-b-and-enniatin-b1-across-the-blood-brain-barrier-and-hints-for-neurotoxic-effects-in-cerebral-cells
#10
Isabel Krug, Matthias Behrens, Melanie Esselen, Hans-Ulrich Humpf
Enniatins are common contaminants of food and feed and belong to the group of the "emerging" mycotoxins, which are produced by various Fusarium species. Although a wide range of toxic effects, like antibacterial, antifungal, insecticidal and cytotoxic properties, have been described in vitro, so far, no cases of mycotoxicosis connected to enniatins in vivo are reported. Among this group of mycotoxins, enniatin B and enniatin B1 are the most prevalent compounds and therefore are present in the human diet...
2018: PloS One
https://www.readbyqxmd.com/read/29768069/analyzing-trend-for-u-s-immigrants-e-health-engagement-from-2008-to-2013
#11
Xinyan Zhao, Bo Yang, Chau-Wai Wong
Our study examines the trend of U.S. immigrants' engagement in various e-health activities and how immigrants' use of e-health technologies is associated with their cultural characteristics over years. Aggregating three national representative samples of U.S. immigrants from the Health Information National Trends Survey (HINTS) conducted between 2008 and 2013, our results from trend analyses and logistic regressions revealed that the U.S. immigrants exhibited an increasing trend on two types of e-health engagement: tracking personal health information online and communicating with a doctor online...
May 16, 2018: Health Communication
https://www.readbyqxmd.com/read/29765799/a-novel-copper-precursor-for-electron-beam-induced-deposition
#12
Caspar Haverkamp, George Sarau, Mikhail N Polyakov, Ivo Utke, Marcos V Puydinger Dos Santos, Silke Christiansen, Katja Höflich
A fluorine free copper precursor, Cu(tbaoac)2 with the chemical sum formula CuC16 O6 H26 is introduced for focused electron beam induced deposition (FEBID). FEBID with 15 keV and 7 nA results in deposits with an atomic composition of Cu:O:C of approximately 1:1:2. Transmission electron microscopy proved that pure copper nanocrystals with sizes of up to around 15 nm were dispersed inside the carbonaceous matrix. Raman investigations revealed a high degree of amorphization of the carbonaceous matrix and showed hints for partial copper oxidation taking place selectively on the surfaces of the deposits...
2018: Beilstein Journal of Nanotechnology
https://www.readbyqxmd.com/read/29760760/differences-in-the-reliance-on-cuticular-hydrocarbons-as-sexual-signaling-and-species-discrimination-cues-in-parasitoid-wasps
#13
Jan Buellesbach, Sebastian G Vetter, Thomas Schmitt
Background: Cuticular hydrocarbons (CHC) have been documented to play crucial roles as species- and sex-specific cues in the chemical communication systems of a wide variety of insects. However, whether they are sufficient by themselves as the sole cue triggering sexual behavior as well as preference of con- over heterospecific mating partners is rarely assessed. We conducted behavioral assays in three representative species of parasitoid wasps (Hymenoptera: Pteromalidae) to determine their reliance on CHC as species-specific sexual signaling cues...
2018: Frontiers in Zoology
https://www.readbyqxmd.com/read/29758235/innovation-and-trends-in-the-development-and-approval-of-antiviral-medicines-1987-2017-and-beyond
#14
REVIEW
Shuvam Chaudhuri, Julian A Symons, Jerome Deval
2017 marked the 30th anniversary of the approval of zidovudine (AZT) as the first HIV/AIDS therapy. Since then, more than eighty antiviral drugs have received FDA approval, half of which treat HIV infection. Here, we provide a retrospective analysis of approved antiviral drugs, including therapeutics against other major chronic infections such as hepatitis B and C, and herpes viruses, over the last thirty years. During this time, only a few drugs were approved to treat acute viral infections, mainly influenza...
May 15, 2018: Antiviral Research
https://www.readbyqxmd.com/read/29758227/effects-of-feedback-delay-on-learning-from-positive-and-negative-feedback-in-patients-with-parkinson-s-disease-off-medication
#15
Benjamin Weismüller, Marta Ghio, Kazimierz Logmin, Christian Hartmann, Alfons Schnitzler, Bettina Pollok, Martin Südmeyer, Christian Bellebaum
Phasic dopamine (DA) signals conveyed from the substantia nigra to the striatum and the prefrontal cortex crucially affect learning from feedback, with DA bursts facilitating learning from positive feedback and DA dips facilitating learning from negative feedback. Consequently, diminished nigro-striatal dopamine levels as in unmedicated patients suffering from Parkinson's Disease (PD) have been shown to lead to a negative learning bias. Recent studies suggested a diminished striatal contribution to feedback processing when the outcome of an action is temporally delayed...
May 11, 2018: Neuropsychologia
https://www.readbyqxmd.com/read/29756303/cholesteric-liquid-crystal-shells-as-enabling-material-for-information-rich-design-and-architecture
#16
REVIEW
Mathew Schwartz, Gabriele Lenzini, Yong Geng, Peter B Rønne, Peter Y A Ryan, Jan P F Lagerwall
The responsive and dynamic character of liquid crystals (LCs), arising from their ability to self-organize into long-range ordered structures while maintaining fluidity, has given them a role as key enabling materials in the information technology that surrounds us today. Ongoing research hints at future LC-based technologies of entirely different types, for instance by taking advantage of the peculiar behavior of cholesteric liquid crystals (CLCs) subject to curvature. Spherical shells of CLC reflect light omnidirectionally with specific polarization and wavelength, tunable from the UV to the infrared (IR) range, with complex patterns arising when many of them are brought together...
May 14, 2018: Advanced Materials
https://www.readbyqxmd.com/read/29755670/systemic-inflammatory-status-predict-the-outcome-of-k-ras-wt-metastatic-colorectal-cancer-patients-receiving-the-thymidylate-synthase-poly-epitope-peptide-anticancer-vaccine
#17
Pierpaolo Correale, Cirino Botta, Nicoletta Staropoli, Valerio Nardone, Pierpaolo Pastina, Cristina Ulivieri, Claudia Gandolfo, Tatiana Cosima Baldari, Stefano Lazzi, Domenico Ciliberto, Rocco Giannicola, Antonella Fioravanti, Antonio Giordano, Silvia Zappavigna, Michele Caraglia, Pierfrancesco Tassone, Luigi Pirtoli, Maria Grazia Cusi, Pierosandro Tagliaferri
TSPP is an anticancer poly-epitope peptide vaccine to thymidylate synthase, recently investigated in the multi-arm phase Ib TSPP/VAC1 trial. TSPP vaccination induced immune-biological effects and showed antitumor activity in metastatic colorectal cancer (mCRC) patients and other malignancies. Progression-free and overall survival of 41 mCRC patients enrolled in the study correlated with baseline levels of CEA, immune-inflammatory markers (neutrophil/lymphocyte ratio, CRP, ESR, LDH, ENA), IL-4 and with post-treatment change in p-ANCA and CD56dim CD16bright NKs ( p < 0...
April 17, 2018: Oncotarget
https://www.readbyqxmd.com/read/29755165/open-access-to-the-evidence-helpful-hints-to-save-valuable-time-and-resources-in-the-quest-to-provide-evidence-informed-physiotherapy-interventions
#18
EDITORIAL
Linda McLean, Paola Durando
No abstract text is available yet for this article.
2018: Physiotherapy Canada. Physiothérapie Canada
https://www.readbyqxmd.com/read/29753882/circulating-tumor-microemboli-progress-in-molecular-understanding-and-enrichment-technologies
#19
REVIEW
Muhammad Umer, Ramanathan Vaidyanathan, Nam-Trung Nguyen, Muhammad J A Shiddiky
Circulating tumor cells (CTCs) and their clusters, also known as circulating tumor microemboli (CTM), have emerged as valuable tool that can provide mechanistic insights into the tumor heterogeneity, clonal evolution, and stochastic events within the metastatic cascade. However, recent investigations have hinted that CTM may not be mere aggregates of tumor cells but cells comprising CTM exhibit distinct phenotypic and molecular characteristics in comparison to single CTCs. Moreover, in many cases CTM demonstrated higher metastatic potential and resistance to apoptosis as compared to their single cell counterparts...
May 10, 2018: Biotechnology Advances
https://www.readbyqxmd.com/read/29749543/comprehensive-analysis-of-the-clinical-significance-and-prospective-molecular-mechanisms-of-differentially-expressed-autophagy-related-genes-in-thyroid-cancer
#20
Peng Lin, Yun He, Dong-Yue Wen, Xiao-Jiao Li, Jing-Jing Zeng, Wei-Jia Mo, Qing Li, Jin-Bo Peng, Yu-Quan Wu, Deng-Hua Pan, Hai-Yuan Li, Qiu-Yan Mo, Yun-Peng Wei, Hong Yang, Gang Chen
Thyroid cancer (TC) is the most common endocrine malignancy, accounting for approximately 90% of all malignancies of the endocrine system. Despite the fact that patients with TC tend to have good prognoses, the high incidence rate and lymph node metastases remain unresolved issues. Autophagy is an indispensable process that maintains intracellular homeostasis; however, the role of autophagy in several steps of the initiation and progression of TC has not yet been elucidated. In this study, we first identified several autophagy-related genes (ARGs) that were provoked in the onset of TC...
May 11, 2018: International Journal of Oncology
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