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Milena M McLaughlin, Erik W Skoglund, Michael G Ison
INTRODUCTION: Peramivir (BCX-1812, RWJ-270201) is a highly selective inhibitor of influenza A and B neuraminidase that has recently been approved in the USA by the FDA to treat acute, uncomplicated influenza in adults. AREAS COVERED: This review examines the discovery and development of peramavir as well as its role in the treatment of influenza. Peramivir is currently the only FDA-approved anti-influenza agent that can be given as an intravenous injection, granting it a unique role in therapy with the potential to improve adherence and outcomes in patients who are unable to tolerate oral agents...
2015: Expert Opinion on Pharmacotherapy
Paul Taylor Akins, John Belko, Timothy M Uyeki, Yekaterina Axelrod, Kenneth K Lee, James Silverthorn
BACKGROUND: Influenza virus infection of the respiratory tract is associated with a range of neurologic complications. The emergence of 2009 pandemic influenza A (H1N1) virus has been linked to neurological complications, including encephalopathy and encephalitis. METHODS: Case report and literature review. RESULTS: We reviewed case management of a 20-year old Hispanic male who developed febrile upper respiratory tract signs and symptoms followed by a confusional state...
December 2010: Neurocritical Care
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