keyword
MENU ▼
Read by QxMD icon Read
search

Immunoinflammatory response

keyword
https://www.readbyqxmd.com/read/27865382/bcg-infection-in-mice-is-promoted-by-na%C3%A3-ve-mesenchymal-stromal-cells-msc-and-suppressed-by-poly-a-u-conditioned-msc
#1
Yakov Sh Schwartz, Sergey N Belogorodtsev, Pavel N Filimonov, Andrey G Cherednichenko, Sergey V Pustylnikov, Vladimir A Krasnov
Mesenchymal stromal cells (MSC) transplantation is an actively studied therapeutic approach used in regenerative medicine and in the field of control of immunoinflammatory response. Conditioning of MSC in culture can form their predominantly pro- or anti-inflammatory phenotypes. We demonstrated that poly(A:U)-conditioning of bone marrow-derived mouse MSC induced predominantly pro-inflammatory phenotype. The effects of administration of naïve MSC (nMSC) or conditioned MSC (cMSC) on the course of mycobacterial infection were studied...
December 2016: Tuberculosis
https://www.readbyqxmd.com/read/27812916/gabab-receptors-as-modulating-target-for-inflammatory-responses-of-the-periodontal-ligament
#2
Anna Konermann, Thomas Van Dyke, Alpdogan Kantarci, Andreas Jäger
PDL cells express GABAB1 and GABAB2 receptors, which are regulated by inflammation and thus might be implicated in periodontal immunology. It was the aim of this study to elucidate the functional role of GABAB receptors in immunomodulation regarding activation of proregenerative versus proinflammatory mechanisms. Human PDL cells were exposed to GABA and/or GABAB receptor antagonist CGP-52432 alone or in combination with IL-1β to mimic inflammation. The influence on marker expression for inflammatory tissue destruction was determined via qRT-PCR and Luminex assays...
November 3, 2016: Cellular and Molecular Neurobiology
https://www.readbyqxmd.com/read/27765767/uvb-exposure-prevents-atherosclerosis-by-regulating-immunoinflammatory-responses
#3
Naoto Sasaki, Tomoya Yamashita, Kazuyuki Kasahara, Atsushi Fukunaga, Tomoyuki Yamaguchi, Takuo Emoto, Keiko Yodoi, Takuya Matsumoto, Kenji Nakajima, Tomoyuki Kita, Masafumi Takeda, Taiji Mizoguchi, Tomohiro Hayashi, Yoshihiro Sasaki, Mayumi Hatakeyama, Kumiko Taguchi, Ken Washio, Shimon Sakaguchi, Bernard Malissen, Chikako Nishigori, Ken-Ichi Hirata
OBJECTIVE: UVB irradiation is an established treatment for immunoinflammatory cutaneous disorders and has been shown to suppress cutaneous and systemic inflammatory diseases through modulation of the adaptive immune response. However, it remains unknown whether UVB irradiation prevents an immunoinflammatory disease of arteries such as atherosclerosis. APPROACH AND RESULTS: Here, we show that UVB exposure inhibits the development and progression of atherosclerosis in atherosclerosis-prone mice by expanding and enhancing the functional capacity of CD4(+) forkhead box P3(+) regulatory T cells and regulating proatherogenic T-cell responses...
October 20, 2016: Arteriosclerosis, Thrombosis, and Vascular Biology
https://www.readbyqxmd.com/read/27759429/gene-expression-profiles-of-hiv-aids-patients-with-qi-yin-deficiency-and-dampness-heat-retention
#4
Sa Liu, Yulong Chen, Shiping Xie, Qianlei Xu, Jianshe Chen, Changhai Wang, Zhao Wang, Suna Ma, Xingwei Wu, Ning Zhang
OBJECTIVES: Traditional Chinese Medicine (TCM) applied in the clinic as a complementary and alternative therapy has helped improve immunity and reduce side effects and symptomatic treatment in patients with HIV/AIDS. However, the mechanisms of TCM syndromes are not clear. Transcriptomics enables the study of such TCM syndromes. DESIGN: This study compared the messenger RNA (mRNA) expressions of healthy persons and patients with HIV/AIDS who had two common TCM syndromes, qi-yin deficiency and dampness-heat retention, to find the difference in HIV/AIDS with TCM syndromes...
November 2016: Journal of Alternative and Complementary Medicine: Research on Paradigm, Practice, and Policy
https://www.readbyqxmd.com/read/27597537/study-of-the-participation-of-mmp-7-emmprin-and-cyclophilin-a-in-the-pathogenesis-of-periodontal-disease
#5
Fernando José de Oliveira Nóbrega, Denise Hélen Imaculada Pereira de Oliveira, Rodrigo Gadelha Vasconcelos, Cassiano Francisco Weege Nonaka, Lélia Maria Guedes Queiroz
BACKGROUND AND OBJECTIVE: Periodontal disease is an infectious disease resulting from the immunoinflammatory response of the host to microorganisms present in the dental biofilm which causes tissue destruction. The objective of this study was to evaluate the immunohistochemical expression of matrix metalloproteinase 7 (MMP-7), extracellular matrix metalloproteinase inducer (EMMPRIN) and cyclophilin A (CypA) in periodontal disease. DESIGN: Gingival tissue samples were divided as follows: clinically healthy gingiva (n=32), biofilm-induced gingivitis (n=28), and chronic periodontitis (n=30)...
August 26, 2016: Archives of Oral Biology
https://www.readbyqxmd.com/read/27465553/mechanisms-underlying-the-association-between-obesity-and-hodgkin-lymphoma
#6
Andreia Matos, Joana Marinho-Dias, Sofia Ramalheira, Maria José Oliveira, Manuel Bicho, Ricardo Ribeiro
A solid body of knowledge indicates that overweight and obese subjects are prone to develop cancer, aggressive disease, and death more than their lean counterparts. While obesity has been causally associated with various cancers, only a limited number of studies beheld the link with classical Hodgkin lymphoma (HL). Contemporary meta-analysis and prospective studies confirmed the association of body mass index with HL. Besides epidemiological evidence, excess adiposity is known to influence tumor behavior through adipokines, adipose-derived stem cell migration, and metabolism regulation, and by modulating immunoinflammatory response...
July 27, 2016: Tumour Biology: the Journal of the International Society for Oncodevelopmental Biology and Medicine
https://www.readbyqxmd.com/read/27403524/dermal-%C3%AE-%C3%AE-t-cells-can-be-activated-by-mitochondrial-damage-associated-molecular-patterns
#7
Martin G Schwacha, Meenakshi Rani, Susannah E Nicholson, Aaron M Lewis, Travis L Holloway, Salvador Sordo, Andrew P Cap
BACKGROUND: Gamma delta T-cells have been shown to be important to the early immunoinflammatory response to injury, independent of infection. This unique T-cell population acts to regulate cell trafficking and the release of cytokines and growth factors. We propose this sterile inflammatory response is in part associated with damage associated molecular patterns (DAMPs) generated by major injury, such as burn, and mediated via toll-like receptors (TLRs). It is unknown whether DAMPs can activate resident γδ T-cells that reside in skin...
2016: PloS One
https://www.readbyqxmd.com/read/27200188/growth-hormone-releasing-peptide-6-enhances-the-healing-process-and-improves-the-esthetic-outcome-of-the-wounds
#8
Yssel Mendoza Marí, Maday Fernández Mayola, Ana Aguilera Barreto, Ariana García Ojalvo, Yilian Bermúdez Alvarez, Ana Janet Mir Benítez, Jorge Berlanga Acosta
In addition to its cytoprotective effects, growth hormone-releasing peptide 6 (GHRP-6) proved to reduce liver fibrotic induration. CD36 as one of the GHRP-6 receptors appears abundantly represented in cutaneous wounds granulation tissue. The healing response in a scenario of CD36 agonistic stimulation had not been previously investigated. Excisional full-thickness wounds (6 mmØ) were created in the dorsum of Wistar rats and topically treated twice a day for 5 days. The universal model of rabbit's ears hypertrophic scars was implemented and the animals were treated daily for 30 days...
2016: Plastic Surgery International
https://www.readbyqxmd.com/read/27160758/inflammation-endothelial-dysfunction-and-arterial-stiffness-as-therapeutic-targets-in-cardiovascular-medicine
#9
Vittoriano Della Corte, Antonino Tuttolomondo, Rosaria Pecoraro, Domenico Di Raimondo, Valerio Vassallo, Antonio Pinto
In the last decades, many factors thought to be associated with the atherosclerotic process and cardiovascular events have been studied, and some of these have been shown to correlate with clinical outcome, such as arterial stiffness, endothelial dysfunction and immunoinflammatory markers. Arterial stiffness is an important surrogate marker that describes the capability of an artery to expand and contract in response to pressure changes. It can be assessed with different techniques, such as the evaluation of PWV and AIx...
2016: Current Pharmaceutical Design
https://www.readbyqxmd.com/read/27040670/modulation-of-inflammatory-and-oxidative-status-by-exercise-attenuates-cardiac-morphofunctional-remodeling-in-experimental-chagas-cardiomyopathy
#10
Rômulo D Novaes, Reggiani V Gonçalves, Arlete R Penitente, Luiz Henrique M Bozi, Clóvis A Neves, Izabel R S C Maldonado, Antônio J Natali, André Talvani
AIMS: The rational basis that explains the benefits of exercise therapy on Chagas cardiomyopathy (ChC) is poorly understood. This study investigated the impact of an exercise program on exercise performance, heart parasitism, immunoinflammatory response, fibrogenesis, oxidative damage, and cardiomyocytes contractility in experimental ChC. MAIN METHODS: Wistar rats were subjected to a 9-week treadmill running training and challenged with Trypanosoma cruzi. Control animals remained sedentary...
May 1, 2016: Life Sciences
https://www.readbyqxmd.com/read/26992426/tumour-associated-and-non-tumour-associated-microbiota-in-colorectal-cancer
#11
Burkhardt Flemer, Denise B Lynch, Jillian M R Brown, Ian B Jeffery, Feargal J Ryan, Marcus J Claesson, Micheal O'Riordain, Fergus Shanahan, Paul W O'Toole
OBJECTIVE: A signature that unifies the colorectal cancer (CRC) microbiota across multiple studies has not been identified. In addition to methodological variance, heterogeneity may be caused by both microbial and host response differences, which was addressed in this study. DESIGN: We prospectively studied the colonic microbiota and the expression of specific host response genes using faecal and mucosal samples ('ON' and 'OFF' the tumour, proximal and distal) from 59 patients undergoing surgery for CRC, 21 individuals with polyps and 56 healthy controls...
March 18, 2016: Gut
https://www.readbyqxmd.com/read/26859687/bone-biology-related-gingival-transcriptome-in-ageing-and-periodontitis-in-non-human-primates
#12
Subramanya N Pandruvada, Octavio A Gonzalez, Sreenatha Kirakodu, Sudha Gudhimella, Arnold J Stromberg, Jeffrey L Ebersole, Luis Orraca, Janis Gonzalez-Martinez, Michael J Novak, Sarandeep S Huja
AIM: Cellular and molecular immunoinflammatory changes in gingival tissues drive alveolar bone loss in periodontitis. Since ageing is a risk factor for periodontitis, we sought to identify age-related gingival transcriptome changes associated with bone metabolism in both healthy and in naturally occurring periodontitis. MATERIALS AND METHODS: Adult (12-16 years) and aged (18-23 years) non-human primates (M. mulatta) (n = 24) were grouped into healthy and periodontitis...
May 2016: Journal of Clinical Periodontology
https://www.readbyqxmd.com/read/26646180/near-infrared-photoactivatable-control-of-ca-2-signaling-and-optogenetic-immunomodulation
#13
Lian He, Yuanwei Zhang, Guolin Ma, Peng Tan, Zhanjun Li, Shengbing Zang, Xiang Wu, Ji Jing, Shaohai Fang, Lijuan Zhou, Youjun Wang, Yun Huang, Patrick G Hogan, Gang Han, Yubin Zhou
The application of current channelrhodopsin-based optogenetic tools is limited by the lack of strict ion selectivity and the inability to extend the spectra sensitivity into the near-infrared (NIR) tissue transmissible range. Here we present an NIR-stimulable optogenetic platform (termed 'Opto-CRAC') that selectively and remotely controls Ca(2+) oscillations and Ca(2+)-responsive gene expression to regulate the function of non-excitable cells, including T lymphocytes, macrophages and dendritic cells. When coupled to upconversion nanoparticles, the optogenetic operation window is shifted from the visible range to NIR wavelengths to enable wireless photoactivation of Ca(2+)-dependent signaling and optogenetic modulation of immunoinflammatory responses...
December 8, 2015: ELife
https://www.readbyqxmd.com/read/26489863/herpesvirus-entry-mediator-on-radiation-resistant-cell-lineages-promotes-ocular-herpes-simplex-virus-1-pathogenesis-in-an-entry-independent-manner
#14
Rebecca G Edwards, Sarah J Kopp, Andrew H Karaba, Douglas R Wilcox, Richard Longnecker
UNLABELLED: Ocular herpes simplex virus 1 (HSV-1) infection leads to a potentially blinding immunoinflammatory syndrome, herpes stromal keratitis (HSK). Herpesvirus entry mediator (HVEM), a widely expressed tumor necrosis factor (TNF) receptor superfamily member with diverse roles in immune signaling, facilitates viral entry through interactions with viral glycoprotein D (gD) and is important for HSV-1 pathogenesis. We subjected mice to corneal infection with an HSV-1 mutant in which HVEM-mediated entry was specifically abolished and found that the HVEM-entry mutant produced clinical disease comparable to that produced by the control virus...
2015: MBio
https://www.readbyqxmd.com/read/26482920/-trp-inflammation-relationship-in-cardiovascular-system
#15
REVIEW
Tomohiro Numata, Kiriko Takahashi, Ryuji Inoue
Despite considerable advances in the research and treatment, the precise relationship between inflammation and cardiovascular (CV) disease remains incompletely understood. Therefore, understanding the immunoinflammatory processes underlying the initiation, progression, and exacerbation of many cardiovascular diseases is of prime importance. The innate immune system has an ancient origin and is well conserved across species. Its activation occurs in response to pathogens or tissue injury. Recent studies suggest that altered ionic balance, and production of noxious gaseous mediators link to immune and inflammatory responses with altered ion channel expression and function...
May 2016: Seminars in Immunopathology
https://www.readbyqxmd.com/read/26416041/prognostic-impact-of-tumor-lymphocytic-infiltrates-in-patients-with-breast-cancer-undergoing-neoadjuvant-chemotherapy
#16
Nilufer Avci, Adem Deligonul, Sahsine Tolunay, Erdem Cubukcu, Omer Fatih Olmez, Ozgur Altmisdortoglu, Ozgur Tanriverdi, Asude Aksoy, Ender Kurt, Turkkan Evrensel
PURPOSE: The presence of a pronounced tumor lymphocytic infiltrate (TLI) is deemed to reflect the presence of an immunoinflammatory response against the tumor and may thus have prognostic significance. We investigated the prognostic value of TLI detected in pathological specimens collected following neoadjuvant chemotherapy (NACT) in patients with breast cancer. METHODS: 100 consecutive patients with breast cancer (mean age 47.8±11.4 years) who were scheduled to undergo anthracycline-and/or taxane-containing NACT were enrolled...
July 2015: Journal of B.U.ON.: Official Journal of the Balkan Union of Oncology
https://www.readbyqxmd.com/read/26347200/relationship-between-periodontitis-and-rheumatoid-arthritis-review-of-the-literature
#17
REVIEW
Vilana Maria Adriano Araújo, Iracema Matos Melo, Vilma Lima
Periodontitis (PD) and rheumatoid arthritis (RA) are immunoinflammatory diseases where leukocyte infiltration and inflammatory mediators induce alveolar bone loss, synovitis, and joint destruction, respectively. Thus, we reviewed the relationship between both diseases considering epidemiological aspects, mechanical periodontal treatment, inflammatory mediators, oral microbiota, and antibodies, using the keywords "periodontitis" and "rheumatoid arthritis" in PubMed database between January 2012 and March 2015, resulting in 162 articles...
2015: Mediators of Inflammation
https://www.readbyqxmd.com/read/26052926/gene-expression-profiling-of-human-vaginal-cells-in-vitro-discriminates-compounds-with-pro-inflammatory-and-mucosa-altering-properties-novel-biomarkers-for-preclinical-testing-of-hiv-microbicide-candidates
#18
Irina A Zalenskaya, Theresa Joseph, Jasmin Bavarva, Nazita Yousefieh, Suzanne S Jackson, Titilayo Fashemi, Hidemi S Yamamoto, Robert Settlage, Raina N Fichorova, Gustavo F Doncel
BACKGROUND: Inflammation and immune activation of the cervicovaginal mucosa are considered factors that increase susceptibility to HIV infection. Therefore, it is essential to screen candidate anti-HIV microbicides for potential mucosal immunomodulatory/inflammatory effects prior to further clinical development. The goal of this study was to develop an in vitro method for preclinical evaluation of the inflammatory potential of new candidate microbicides using a microarray gene expression profiling strategy...
2015: PloS One
https://www.readbyqxmd.com/read/25996609/spontaneous-post-transplant-disorders-in-nod-cg-prkdcscid-il2rgtm1sug-jictac-nog-mice-engrafted-with-patient-derived-metastatic-melanomas
#19
Enrico Radaelli, Els Hermans, Lorna Omodho, Annick Francis, Sara Vander Borght, Jean-Christophe Marine, Joost van den Oord, Frédéric Amant
Patient-derived tumor xenograft (PDTX) approach is nowadays considered a reliable preclinical model to study in vivo cancer biology and therapeutic response. NOD scid and Il2rg-deficient mice represent the "gold standard" host for the generation of PDTXs. Compared to other immunocompromised murine lines, these mice offers several advantages including higher engraftment rate, longer lifespan and improved morphological and molecular preservation of patient-derived neoplasms. Here we describe a spectrum of previously uncharacterized post-transplant disorders affecting 14/116 (12%) NOD...
2015: PloS One
https://www.readbyqxmd.com/read/25990461/monocyte-trafficking-across-the-vessel-wall
#20
REVIEW
Teresa Gerhardt, Klaus Ley
Monocytes fundamentally contribute to immune surveillance and the inflammatory response in immunoinflammatory diseases like atherosclerosis. Recruitment of these cells to the site of injury requires their trafficking across the blood vessel wall. A series of events, including capture, rolling, slow rolling, arrest, adhesion strengthening, and lateral locomotion, precede monocyte transmigration. Recent investigations have revealed new aspects of this cascade. This article revisits some conventional paradigms and selectively highlights new findings, including novel insights into monocyte differentiation and recently identified functional mediators, signalling pathways, and new structural aspects of monocyte extravasation...
August 1, 2015: Cardiovascular Research
keyword
keyword
114077
1
2
Fetch more papers »
Fetching more papers... Fetching...
Read by QxMD. Sign in or create an account to discover new knowledge that matter to you.
Remove bar
Read by QxMD icon Read
×

Search Tips

Use Boolean operators: AND/OR

diabetic AND foot
diabetes OR diabetic

Exclude a word using the 'minus' sign

Virchow -triad

Use Parentheses

water AND (cup OR glass)

Add an asterisk (*) at end of a word to include word stems

Neuro* will search for Neurology, Neuroscientist, Neurological, and so on

Use quotes to search for an exact phrase

"primary prevention of cancer"
(heart or cardiac or cardio*) AND arrest -"American Heart Association"