keyword
MENU ▼
Read by QxMD icon Read
search

erbb4

keyword
https://www.readbyqxmd.com/read/28435121/proteome-analysis-of-human-embryonic-stem-cells-organelles
#1
Faezeh Shekari, Hossein Nezari, Mehran Rezaei Larijani, Chia-Li Han, Hossein Baharvand, Yu-Ju Chen, Ghasem Hosseini Salekdeh
As the functions of proteins are associated with their cellular localization, the comprehensive sub-cellular proteome knowledge of human embryonic stem cells (hESCs) is indispensable for ensuring a therapeutic effect. Here, we have utilized a sub-cellular proteomics approach to analyze the localization of proteins in the nucleus, mitochondria, crude membrane, cytoplasm, heavy and light microsomes. Out of 2002 reproducibly identified proteins, we detected 762 proteins in a single organelle whereas 160 proteins were found in all sub-cellular fractions...
April 20, 2017: Journal of Proteomics
https://www.readbyqxmd.com/read/28432142/structural-similarities-between-neuregulin-1-3-isoforms-determine-their-subcellular-distribution-and-signaling-mode-in-central-neurons
#2
Detlef Vullhorst, Tanveer Ahmad, Irina Karavanova, Carolyn Keating, Andres Buonanno
The Neuregulin (NRG) family of ErbB ligands is comprised of numerous variants originating from the use of different genes, alternative promoters and splice variants. NRGs have generally been thought to be transported to axons and presynaptic terminals where they signal via ErbB3/4 receptors in paracrine or juxtacrine mode. However, we recently demonstrated that unprocessed pro-NRG2 accumulates on cell bodies and proximal dendrites, and that NMDAR activity is required for shedding of its ectodomain by metalloproteinases...
April 21, 2017: Journal of Neuroscience: the Official Journal of the Society for Neuroscience
https://www.readbyqxmd.com/read/28425244/genetic-association-analysis-of-erbb4-polymorphisms-with-the-risk-ofschizophrenia-susceptibility-in-a-jordanian-population-of-arab-descent
#3
Laith Al-Eitan, Sahar Al-Habahbeh, Rami Alkhatib
BACKGROUND/AIM: The ERBB4 gene encodes a transmembrane tyrosine kinase and is considered to be one of the risk genes of schizophrenia. Although there is evidence of the roles of genes and the environment in the etiology of schizophrenia, a comprehensive biological and genetic background of the disease is still lacking. The aim of this study is to assess whether genetic variation in the human ERBB4 gene is associated with vulnerability to schizophrenia in the Jordanian Arab population...
April 18, 2017: Turkish Journal of Medical Sciences
https://www.readbyqxmd.com/read/28421673/endothelial-erbb4-deficit-induces-alterations-in-exploratory-behavior-and-brain-energy-metabolism-in-mice
#4
Gang Wu, Xiu-Xiu Liu, Nan-Nan Lu, Qi-Bing Liu, Yun Tian, Wei-Feng Ye, Guo-Jun Jiang, Rong-Rong Tao, Feng Han, Ying-Mei Lu
AIMS: The receptor tyrosine kinase ErbB4 is present throughout the primate brain and has a distinct functional profile. In this study, we investigate the potential role of endothelial ErbB4 receptor signaling in the brain. RESULTS: Here, we show that the endothelial cell-specific deletion of ErbB4 induces decreased exploratory behavior in adult mice. However, the water maze task for spatial memory and the memory reconsolidation test reveal no changes; additionally, we observe no impairment in CaMKII phosphorylation in Cdh5Cre;ErbB4(f/f) mice, which indicates that the endothelial ErbB4 deficit leads to decreased exploratory activity rather than direct memory deficits...
April 18, 2017: CNS Neuroscience & Therapeutics
https://www.readbyqxmd.com/read/28402449/enhancement-of-trophoblast-differentiation-and-survival-by-low-molecular-weight-heparin-requires-heparin-binding-egf-like-growth-factor
#5
Alan D Bolnick, Jay M Bolnick, Hamid-Reza Kohan-Ghadr, Brian A Kilburn, Omar J Pasalodos, Pankaj K Singhal, Jing Dai, Michael P Diamond, D Randall Armant, Sascha Drewlo
STUDY QUESTION: Does low molecular weight heparin (LMWH) require heparin-binding epidermal growth factor (EGF)-like growth factor (HBEGF) signaling to induce extravillous trophoblast differentiation and decrease apoptosis during oxidative stress? SUMMARY ANSWER: LMWH increased HBEGF expression and secretion, and HBEGF signaling was required to stimulate trophoblast extravillous differentiation, increase invasion in vitro and reduce trophoblast apoptosis during oxidative stress...
April 10, 2017: Human Reproduction
https://www.readbyqxmd.com/read/28394918/a-novel-technique-of-serial-biopsy-in-mouse-brain-tumour-models
#6
Sasha Rogers, Hilary Hii, Joel Huang, Mathew Ancliffe, Nick G Gottardo, Peter Dallas, Sharon Lee, Raelene Endersby
Biopsy is often used to investigate brain tumour-specific abnormalities so that treatments can be appropriately tailored. Dacomitinib (PF-00299804) is a tyrosine kinase inhibitor (TKI), which is predicted to only be effective in cancers where the targets of this drug (EGFR, ERBB2, ERBB4) are abnormally active. Here we describe a method by which serial biopsy can be used to validate response to dacomitinib treatment in vivo using a mouse glioblastoma model. In order to determine the feasibility of conducting serial brain biopsies in mouse models with minimal morbidity, and if successful, investigate whether this can facilitate evaluation of chemotherapeutic response, an orthotopic model of glioblastoma was used...
2017: PloS One
https://www.readbyqxmd.com/read/28394697/genetic-study-of-neuregulin-1-and-receptor-tyrosine-protein-kinase-erbb-4-in-tardive-dyskinesia
#7
Clement C Zai, Arun K Tiwari, Nabilah I Chowdhury, Zeynep Yilmaz, Vincenzo de Luca, Daniel J Müller, Steven G Potkin, Jeffrey A Lieberman, Herbert Y Meltzer, Aristotle N Voineskos, Gary Remington, James L Kennedy
OBJECTIVES: Tardive dyskinesia (TD) is a movement disorder that may develop as a side effect of antipsychotic medication. The aetiology underlying TD is unclear, but a number of mechanisms have been proposed. METHODS: We investigated single-nucleotide polymorphisms (SNPs) in the genes coding for neuregulin-1 and erbB-4 receptor in our sample of 153 European schizophrenia patients for possible association with TD. RESULTS: We found the ERBB4 rs839523 CC genotype to be associated with risk for TD occurrence and increased severity as measured by the Abnormal Involuntary Movement Scale (AIMS) (P = ...
April 10, 2017: World Journal of Biological Psychiatry
https://www.readbyqxmd.com/read/28394324/abnormal-wiring-of-cck-basket-cells-disrupts-spatial-information-coding
#8
Isabel Del Pino, Jorge R Brotons-Mas, André Marques-Smith, Aline Marighetto, Andreas Frick, Oscar Marín, Beatriz Rico
The function of cortical GABAergic interneurons is largely determined by their integration into specific neural circuits, but the mechanisms controlling the wiring of these cells remain largely unknown. This is particularly true for a major population of basket cells that express the neuropeptide cholecystokinin (CCK). Here we found that the tyrosine kinase receptor ErbB4 was required for the normal integration into cortical circuits of basket cells expressing CCK and vesicular glutamate transporter 3 (VGlut3)...
April 10, 2017: Nature Neuroscience
https://www.readbyqxmd.com/read/28386192/study-of-lung-cancer-regulatory-network-that-involves-erbb4-and-tumor-marker-gene
#9
Xuhui Ma, Lu Li, Tongde Tian, Huaimin Liu, Qiujian Li, Qilong Gao
Our purpose is to screen out serum tumor markers closely correlated to the nature of solitary pulmonary nodule (SPN) and to draw a regulatory network containing genes correlated to lung cancer. Two hundred and sixty cases of SPN patients confirmed through pathological diagnosis were collected as subjects, factors closely correlated to the nature of SPN were screened out from eight tumor markers through Fisher discriminant method, and functional annotation and pathway analysis were conducted on erbB4 as well as its tumor marker genes by GO and KEGG databases...
March 2017: Saudi Journal of Biological Sciences
https://www.readbyqxmd.com/read/28384043/association-of-%C3%AE-secretase-functional-polymorphism-with-risk-of-schizophrenia
#10
Simin Rahimi-Aliabadi, Neda Shahmohammadibeni, Javad Jamshidi, Ehsan Esmaili Shandiz, Reza Mirfakhraie, Mina Ohadi, Farhad Ramezani Nejad, Nader Mansoori, Mohammad Taheri, Fatemeh Gholipour, Susan Moudi, Gouya Tayebi, Shahram Divsalar, Hossein Darvish, Abolfazl Movafagh
AIM: The NRG1-ERBB4 neurotransmitter signaling pathway plays a key role in the pathogenesis of schizophrenia (SZ). The intronic single-nucleotide polymorphism rs707284 in ERBB4 links to PI3K-AKT suppression in SZ. Another protein indirectly affecting NRG1-ERBB4 signaling is β-secretase, which is encoded by the BACE1 gene, and activates NRG1 by proteolytic cleavage. In this study, we aimed to investigate the association of ERBB4 rs707284 and BACE1 rs490460 with the risk of SZ in an Iranian population...
April 2017: Genetic Testing and Molecular Biomarkers
https://www.readbyqxmd.com/read/28383694/genetic-variations-in-cancer-related-significantly-mutated-genes-and-lung-cancer-susceptibility
#11
Y Zhang, L Zhang, R Li, D W Chang, Y Ye, J D Minna, J A Roth, B Han, X Wu
Background: Cancer initiation and development are driven by key mutations in driver genes. Applying high-throughput sequencing technologies and bioinformatic analyses, The Cancer Genome Atlas (TCGA) project has identified panels of somatic mutations that contributed to the etiology of various cancers. However, there are few studies investigating the germline genetic variations in these significantly mutated genes (SMGs) and lung cancer susceptibility. Patients and Methods: We comprehensively evaluated 1655 tagged SNPs located in 127 SMGs identified by TCGA, and test their association with lung cancer risk in large-scale case-control study...
April 5, 2017: Annals of Oncology: Official Journal of the European Society for Medical Oncology
https://www.readbyqxmd.com/read/28379301/embryo-arrest-and-reactivation-potential-candidates-controlling-embryonic-diapause-in-the-tammar-wallaby-and-mink1
#12
Jane C Fenelon, Geoffrey Shaw, Stephen R Frankenberg, Bruce D Murphy, Marilyn B Renfree
Embryonic diapause is period of developmental arrest which requires coordination of a molecular cross-talk between the endometrium and blastocyst to ensure a successful reactivation, but the exact mechanisms are undefined. The objectives of this study were to screen the tammar blastocyst for potential diapause control factors and to investigate the potential for members of the epidermal growth factor (EGF) family to coordinate reactivation. A select number of factors were also examined in the mink to determine whether their expression patterns were conserved across diapause species...
March 31, 2017: Biology of Reproduction
https://www.readbyqxmd.com/read/28371053/nanoparticulate-tio2-mediated-inhibition-of-the-wnt-signaling-pathway-causes-dendritic-development-disorder-in-cultured-rat-hippocampal-neurons
#13
Fashui Hong, Yuguan Ze, Yaoming Zhou, Jie Hong, Xiaohon Yu, Lei Sheng, Ling Wang
Titanium dioxide nanoparticles (TiO2 NPs) are increasingly used in daily life, in industry and in environmental clearing, but their potential neurodevelopmental toxicity has been highly debated. In this study, we explored whether TiO2 NPs inhibited development of dendritic morphology and identified possible molecular mechanisms associated with this inhibition in primary cultured rat hippocampal neurons. Results showed that TiO2 NPs decreased neurite length, the number of branches and the spine density, and impaired mitochondrial function in the developing neurons...
March 28, 2017: Journal of Biomedical Materials Research. Part A
https://www.readbyqxmd.com/read/28368926/basal-cell-carcinoma-with-matrical-differentiation-clinicopathologic-immunohistochemical-and-molecular-biological-study-of-22-cases
#14
Liubov Kyrpychova, Richard A Carr, Petr Martinek, Tomas Vanecek, Raul Perret, Magdalena Chottová-Dvořáková, Michal Zamecnik, Ladislav Hadravsky, Michal Michal, Dmitry V Kazakov
Basal cell carcinoma (BCC) with matrical differentiation is a fairly rare neoplasm, with about 30 cases documented mainly as isolated case reports. We studied a series of this neoplasm, including cases with an atypical matrical component, a hitherto unreported feature. Lesions coded as BCC with matrical differentiation were reviewed; 22 cases were included. Immunohistochemical studies were performed using antibodies against BerEp4, β-catenin, and epithelial membrane antigen (EMA). Molecular genetic studies using Ion AmpliSeq Cancer Hotspot Panel v2 by massively parallel sequencing on Ion Torrent PGM were performed in 2 cases with an atypical matrical component (1 was previously subjected to microdissection to sample the matrical and BCC areas separately)...
March 31, 2017: American Journal of Surgical Pathology
https://www.readbyqxmd.com/read/28359267/aberrant-expression-of-alk-and-ezh2-in-merkel-cell-carcinoma
#15
Tuukka Veija, Virve Koljonen, Tom Bohling, Mia Kero, Sakari Knuutila, Virinder Kaur Sarhadi
BACKGROUND: Distinct characteristic features categorize Merkel cell carcinoma (MCC) into two subgroups according to the Merkel cell polyomavirus infection. Many mutational studies on MCC have been carried out in recent years without identifying a prominent driver mutation. However, there is paucity reporting the expression of cancer genes at the RNA level in MCC tumors. In this study, we studied the RNA expression profiles of 26 MCC tumors, with a goal to identify prospective molecular targets that could improve the treatment strategies of MCC...
March 31, 2017: BMC Cancer
https://www.readbyqxmd.com/read/28356599/towards-personalized-medicine-in-melanoma-implementation-of-a-clinical-next-generation-sequencing-panel
#16
Blanca de Unamuno Bustos, Rosa Murria Estal, Gema Pérez Simó, Inmaculada de Juan Jimenez, Begoña Escutia Muñoz, Mercedes Rodríguez Serna, Victor Alegre de Miquel, Margarita Llavador Ros, Rosa Ballester Sánchez, Eduardo Nagore Enguídanos, Sarai Palanca Suela, Rafael Botella Estrada
Molecular diagnostics are increasingly performed routinely in the diagnosis and management of patients with melanoma due to the development of novel therapies that target specific genetic mutations. The development of next-generation sequencing (NGS) technologies has enabled to sequence multiple cancer-driving genes in a single assay, with improved sensitivity in mutation detection. The main objective of this study was the design and implementation of a melanoma-specific sequencing panel, and the identification of the spectrum of somatic mutations in a series of primary melanoma samples...
March 29, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28347234/clinical-value-of-mir-145-5p-in-nsclc-and-potential-molecular-mechanism-exploration-a-retrospective-study-based-on-geo-qrt-pcr-and-tcga-data
#17
Ting-Qing Gan, Zu-Cheng Xie, Rui-Xue Tang, Tong-Tong Zhang, Dong-Yao Li, Zu-Yun Li, Gang Chen
MicroRNAs have been reported to be involved in various biological processes. Here, we performed a systematic analysis to explore the clinical value and potential molecular mechanism of miR-145-5p in non-small cell lung cancer. First, a meta-analysis was performed with eligible literature, followed by microRNA microarrays in the Gene Expression Omnibus database, to verify the diagnostic and prognostic values of miR-145-5p. A cohort of 125 clinical paired non-small cell lung cancer samples was next used to detect the level of miR-145-5p and to explore the relationship of miR-145-5p with clinicopathological parameters...
March 2017: Tumour Biology: the Journal of the International Society for Oncodevelopmental Biology and Medicine
https://www.readbyqxmd.com/read/28338897/specialized-information-processing-deficits-and-distinct-metabolomic-profiles-following-tm-domain-disruption-of-nrg1
#18
Colm M P O'Tuathaigh, Naina Mathur, Matthew J O'Callaghan, Lynsey MacIntyre, Richard Harvey, Donna Lai, John L Waddington, Benjamin S Pickard, David G Watson, Paula M Moran
Although there is considerable genetic and pathologic evidence for an association between neuregulin 1 (NRG1) dysregulation and schizophrenia, the underlying molecular and cellular mechanisms remain unclear. Mutant mice containing disruption of the transmembrane (TM) domain of the NRG1 gene constitute a heuristic model for dysregulation of NRG1-ErbB4 signaling in schizophrenia. The present study focused on hitherto uncharacterized information processing phenotypes in this mutant line. Using a mass spectrometry-based metabolomics approach, we also quantified levels of unique metabolites in brain...
March 11, 2017: Schizophrenia Bulletin
https://www.readbyqxmd.com/read/28338617/egfr-family-members-regulation-of-autophagy-is-at-a-crossroads-of-cell-survival-and-death-in-cancer
#19
REVIEW
Elizabeth Henson, Yongqiang Chen, Spencer Gibson
The epidermal growth factor receptor (EGFR) signaling pathways are altered in many cancers contributing to increased cell survival. These alterations are caused mainly through increased expression or mutation of EGFR family members EGFR, ErbB2, ErbB3, and ErbB4. These receptors have been successfully targeted for cancer therapy. Specifically, a monoclonal antibody against ErbB2, trastuzumab, and a tyrosine kinase inhibitor against EGFR, gefitinib, have improved the survival of breast and lung cancer patients...
March 24, 2017: Cancers
https://www.readbyqxmd.com/read/28334319/erbb4-acts-as-a-suppressor-in-the-development-of-hepatocellular-carcinoma
#20
Yao Liu, Liming Song, Hengli Ni, Lina Sun, Weijuan Jiao, Lin Chen, Qun Zhou, Tong Shen, Hongxia Cui, Tianming Gao, Jianming Li
ERBB4, one member of the epidermal growth factor receptor (EGFR) family, plays a key role in physiological and pathological processes. Recently, we identified that ERBB4 played a protective role from chronic hepatitis B virus infection. However, the role of ERBB4 in hepatocellular carcinoma (HCC) is still unclear. Here, we explore the role of ERBB4 in the development of HCC using in vitro models, in vivo animal models and clinical samples of HCC. Liver-specific ERBB4 knockout alleles and full ERBB4 except heart knockout mice were used in this study...
April 1, 2017: Carcinogenesis
keyword
keyword
114068
1
2
Fetch more papers »
Fetching more papers... Fetching...
Read by QxMD. Sign in or create an account to discover new knowledge that matter to you.
Remove bar
Read by QxMD icon Read
×

Search Tips

Use Boolean operators: AND/OR

diabetic AND foot
diabetes OR diabetic

Exclude a word using the 'minus' sign

Virchow -triad

Use Parentheses

water AND (cup OR glass)

Add an asterisk (*) at end of a word to include word stems

Neuro* will search for Neurology, Neuroscientist, Neurological, and so on

Use quotes to search for an exact phrase

"primary prevention of cancer"
(heart or cardiac or cardio*) AND arrest -"American Heart Association"