Xiao-Lin Hou, Bin Zhang, Kai Cheng, Fang Zhang, Xiao-Ting Xie, Wei Chen, Lin-Fang Tan, Jin-Xuan Fan, Bo Liu, Qiu-Ran Xu
Customizable and number-tunable enzyme delivery nanocarriers will be useful in tumor therapy. Herein, a phage vehicle, T4-Lox-DNA-Fe (TLDF), which adeptly modulates enzyme numbers using phage display technology to remodel the tumor microenvironment (TME) is presented. Regarding the demand for lactic acid in tumors, each phage is engineered to display 720 lactate oxidase (Lox), contributing to the depletion of lactic acid to restructure the tumor's energy metabolism. The phage vehicle incorporated dextran iron (Fe) with Fenton reaction capabilities...
April 6, 2024: Advanced Science (Weinheim, Baden-Wurttemberg, Germany)