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Mycobacterium avium intracellulare

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https://www.readbyqxmd.com/read/28719321/association-of-interferon-%C3%AE-receptor-1-gene-polymorphism-with-nontuberculous-mycobacterial-lung-infection-among-iranian-patients-with-pulmonary-disease
#1
Poopak Farnia, Jalaledin Ghanavi, Shima Saif, Parissa Farnia, Ali Akbar Velayati
Nontuberculous mycobacteria (NTM) cause significant pulmonary infections in humans. Researchers have reported an association between interferon-gamma receptor-1 (IFN-γR1 or IFNGR1) deficiency and susceptibility to NTM, but the relevance of polymorphism within these genes is not yet clear. In this study, a single nucleotide polymorphism (SNP), T to C, at position-56 in NTM patients with pulmonary disease was investigated. Molecular identification of Mycobacterium isolates was performed with hsp65 genes using polymerase chain reaction restriction fragment length polymorphism (PCR-RFLP)...
July 2017: American Journal of Tropical Medicine and Hygiene
https://www.readbyqxmd.com/read/28708727/splenic-involvement-in-disseminated-mycobacterium-avium-intracellulare-infection-magnetic-resonance-imaging-findings
#2
Haley Clark, Gaurav Khatri, Payal Kapur, Ivan Pedrosa
We report the imaging findings of a patient with disseminated Mycobacterium avium-intracellulare complex presenting with multiple splenic lesions incompletely characterized on computed tomography in whom magnetic resonance imaging helped narrow the differential diagnosis. We discuss the magnetic resonance imaging findings suggesting the diagnosis, including the presence of focal susceptibility artifact within the lesions (ie, signal drop on T1 in-phase imaging), marked hypointensity on diffusion-weighted imaging, and faint progressive peripheral enhancement after contrast administration...
July 13, 2017: Journal of Computer Assisted Tomography
https://www.readbyqxmd.com/read/28705770/in%C3%A2-vitro-activity-of-aminoglycosides-clofazimine-d-cycloserine-and-dapsone-against-83-mycobacterium-avium-complex-clinical-isolates
#3
Chen-Cheng Huang, Ming-Feng Wu, Hui-Chen Chen, Wei-Chang Huang
BACKGROUND/PURPOSE: Treatment success rates for Mycobacterium avium complex (MAC) diseases range from 50% to 55% only. To explore effective antimicrobials against either Mycobacteriumintracellulare or M. avium, we determined in vitro activities of five aminoglycosides, clofazimine, dapsone and d-cycloserine compared with primary (clarithromycin) and secondary (moxifloxacin and linezolid) antimycobacterial agents. METHODS: 83 non-duplicate clinical MAC isolates were collected from sputum and identified at the species level by PCR and restriction enzyme analysis of the 65 kDa hsp and rpoB genes...
June 28, 2017: Journal of Microbiology, Immunology, and Infection, Wei Mian Yu Gan Ran za Zhi
https://www.readbyqxmd.com/read/28665061/recovery-rates-of-non-tuberculous-mycobacteria-from-clinical-specimens-are-increasing-in-korean-tertiary-care-hospitals
#4
Namhee Kim, Jongyoun Yi, Chulhun L Chang
Non-tuberculous mycobacteria (NTM) are being recognized increasingly as the causative agents of opportunistic infections in humans. This study investigated the epidemiologic trends of NTM recovery from various clinical specimens in 2 Korean tertiary-care hospitals. We reviewed the laboratory records of patient samples cultured for mycobacteria between 2009 and 2015 at 2 tertiary-care hospitals in Korea. The medical records for patients with positive NTM samples were also reviewed. During the study period, 144,540 specimens were cultured for mycobacteria...
August 2017: Journal of Korean Medical Science
https://www.readbyqxmd.com/read/28659320/development-of-a-one-step-multiplex-pcr-assay-for-differential-detection-of-major-mycobacterium-species
#5
Hansong Chae, Seung Jung Han, Su Young Kim, Chang-Seok Ki, Hee Jae Huh, Dongeun Yong, Won-Jung Koh, Sung Jae Shin
The prevalence of tuberculosis continues to be high, and nontuberculous mycobacteria (NTM) infection has also emerged worldwide. Moreover, differential and accurate identification of mycobacteria to the species or subspecies level is an unmet clinical need. Here, we developed a one-step multiplex PCR assay using whole-genome analysis and bioinformatics to identify novel molecular targets. The aims of this assay were to: 1) discriminate between the Mycobacterium tuberculosis complex (MTBC) and NTM using rv0577 or RD750; 2) differentiate M...
June 28, 2017: Journal of Clinical Microbiology
https://www.readbyqxmd.com/read/28623492/recombinant-20-8-kda-protein-of-mycobacterium-avium-subsp-paratuberculosis-based-sero-diagnosis-of-paratuberculosis
#6
P P Goswami, Gokul Chand, N S Prasad, R Deb, S H Basagoudanavar
Johne's disease or paratuberculosis is a chronic infectious enteric disease of ruminants caused by the intracellular pathogen. The control of the Johne's disease is hampered by lack of specific diagnostic tests. In this study, we have cloned and expressed the N-terminal region of the locus tag Map 1637c encoding 20.8-kDa (r20.8) protein of Mycobacterium avium subsp. paratuberculosis. The recombinant protein r20.8 was expressed in high levels in Escherichia coli. The protein r20.8 was purified by single-step chromatography using Ni-NTA agarose...
July 2017: 3 Biotech
https://www.readbyqxmd.com/read/28619015/nontuberculosis-mycobacterial-infections-at-a-specialized-tuberculosis-treatment-centre-in-the-republic-of-korea
#7
Hee Jung Yoon, Hwa Young Choi, Moran Ki
BACKGROUND: The incidence of nontuberculous mycobacteria (NTM) infections is increasing worldwide, however formal evaluations of the epidemiology of NTM infections are limited. Understanding the trends and true prevalence of NTM is a major priority for optimizing infection control programmes and resources. The purpose of this study was to investigate the epidemiology, clinical manifestations, and radiologic findings in NTM-infected patients at specialized Tuberculosis (Tb) treatment centre in South Korea, which is endemic to Tb, and find solutions to control NTM infections...
June 15, 2017: BMC Infectious Diseases
https://www.readbyqxmd.com/read/28606745/the-characteristics-of-patients-with-pulmonary-mycobacterium-avium-intracellulare-complex-disease-diagnosed-by-bronchial-lavage-culture-compared-to-those-diagnosed-by-sputum-culture
#8
Koichi Maekawa, Megumi Naka, Saki Shuto, Yuka Harada, Yumiko Ikegami
BACKGROUND AND OBJECTIVE: The utility of bronchoscopy for the diagnosis of pulmonary Mycobacterium avium-intracellulare complex (MAC) disease has been reported; however, which patients require bronchoscopy remains unclear. Our objective was to identify the characteristics of the patients in whom bronchoscopy is needed for the diagnosis of MAC disease. METHODS: Fifty-four patients with pulmonary MAC disease were divided into two groups according to established diagnostic criteria: 39 patients were diagnosed by sputum culture and 15 patients were diagnosed by bronchial lavage culture...
June 10, 2017: Journal of Infection and Chemotherapy: Official Journal of the Japan Society of Chemotherapy
https://www.readbyqxmd.com/read/28573139/analysis-of-differentially-expressed-proteins-in-mycobacterium-avium-infected-macrophages-comparing-with-mycobacterium-tuberculosis-infected-macrophages
#9
Dongjun Yang, Xin Fu, Shiyi He, Xueping Ning, Min Ling
Mycobacterium avium (MA) belongs to the intracellular parasitic bacteria. To better understand how MA survives within macrophages and the different pathogenic mechanisms of MA and Mycobacterium tuberculosis (MTB), tandem mass tag (TMT) and liquid chromatography-tandem mass spectrometry (LC-MS/MS) analysis have been used to determine the proteins which are differentially expressed in MA-infected and MTB-infected macrophages. 369 proteins were found to be differentially expressed in MA-infected cells but not in MTB-infected cells...
2017: BioMed Research International
https://www.readbyqxmd.com/read/28538280/a-case-of-cavitary-pulmonary-mycobacterium-avium-intracellulare-infection-in-the-setting-of-leflunomide-treatment
#10
Daniel E Winetsky, Jennifer Myers, Steffan Schulz, Gregory Tino, Marissa Wilck
No abstract text is available yet for this article.
June 2017: Journal of Clinical Rheumatology: Practical Reports on Rheumatic & Musculoskeletal Diseases
https://www.readbyqxmd.com/read/28512635/drug-susceptibility-of-33-reference-strains-of-slowly-growing-mycobacteria-to-19-antimicrobial-agents
#11
Hui Pang, Yi Jiang, Kanglin Wan
Objectives. Slowly growing mycobacteria (SGM) are prevalent worldwide and cause an extensive spectrum of diseases. Methods. In this study, the antimicrobial susceptibility of 33 reference strains of SGM to 19 antimicrobial agents was tested using a modified microdilution method. Results. Cefmetazole (32/33) and azithromycin (32/33) exhibited the highest antimicrobial activity, and dapsone (9/33) exhibited the lowest activity against the tested strains. Cefoxitin (30/33), cefoperazone (28/33), and cefepime (28/33) were effective against a high proportion of strains, and macrolides were also highly effective as well as offering the benefit of convenient oral administration to patients...
2017: BioMed Research International
https://www.readbyqxmd.com/read/28511780/anti-mycobacterium-avium-complex-activity-of-clarithromycin-rifampin-rifabutin-and-ethambutol-in-combination-with-adenosine-5-triphosphate
#12
Yutaka Tatano, Seiko Yamabe, Chiaki Sano, Haruaki Tomioka
We previously reported that adenosine 5'-triphosphate (ATP) inhibited the growth of various bacteria, including mycobacteria, Staphylococcus, and Pseudomonas, without damaging bacterial surface structures. Notably, ATP's antibacterial activity was found to be attributable to its iron-chelating ability. ATP exhibited combined effects with some antimicrobials against Mycobacterium intracellulare and methicillin-resistant S. aureus, suggesting its usefulness as an adjunctive drug in the chemotherapy against certain intractable infections...
May 2, 2017: Diagnostic Microbiology and Infectious Disease
https://www.readbyqxmd.com/read/28506264/an-association-between-pulmonary-mycobacterium-avium-intracellulare-complex-infections-and-biomarkers-of-th2-type-inflammation
#13
Paul E Pfeffer, Susan Hopkins, Ian Cropley, David M Lowe, Marc Lipman
BACKGROUND: The rising incidence of pulmonary Mycobacterium avium-intracellulare complex (MAI) infection is unexplained but parallels the growing world-wide epidemic of allergic disease. We hypothesized an association between pulmonary MAI infection and Th2-type immune responses as seen in allergy. METHODS: Biomarkers of patient Th2-type immune responses (peripheral blood eosinophil counts and serum IgE levels) were compared between patients with positive pulmonary samples for tuberculosis and non-tuberculous mycobacterial (NTM) infection...
May 15, 2017: Respiratory Research
https://www.readbyqxmd.com/read/28504926/accurate-differentiation-of-mycobacterium-chimaera-from-mycobacterium-intracellulare-by-maldi-tof-ms-analysis
#14
Arthur B Pranada, Ellen Witt, Michael Bienia, Markus Kostrzewa, Markus Timke
PURPOSE: The increasing number of infections caused by nontuberculous mycobacteria (NTM) has prompted the need for rapid and precise identification methods of these pathogens. Several studies report the applicability of MALDI-TOF mass spectrometry (MS) for identification of NTM. However, some closely related species have very similar spectral mass fingerprints, and until recently, Mycobacterium chimaera and M. intracellulare could not be separated from each other by MALDI-TOF MS. METHODOLOGY: The conventional identification methods used in routine diagnostics have similar limitations...
May 2017: Journal of Medical Microbiology
https://www.readbyqxmd.com/read/28468858/misidentification-of-mycobacterium-paraense-as-mycobacterium-avium-complex-by-accuprobe
#15
LETTER
Husain Poonawala, Vincent E Piscitelli, Lynn Ladutko, Sheldon Campbell
No abstract text is available yet for this article.
July 2017: Journal of Clinical Microbiology
https://www.readbyqxmd.com/read/28424429/the-volatile-molecule-signature-of-four-mycobacteria-species
#16
Theodore Mellors, Christiaan Rees, Wendy Wieland-Alter, C Fordham von Reyn, Jane E Hill
Mycobacteria are the leading cause of death from infectious disease worldwide and limitations in current diagnostics are hampering control efforts. In recent years, the use of small volatile molecules as diagnostic biomarkers for mycobacteria has shown promise for use in the rapid analysis of in vitro cultures as well as ex vivo diagnosis using breath or sputum. In this study, 18 strains from four mycobacteria species (Mycobacterium avium, M. bovis BCG, M. intracellulare and M. xenopi) were analyzed for the first time using two-dimensional gas chromatography time-of-flight mass spectrometry (GC×GC-TOFMS)...
April 20, 2017: Journal of Breath Research
https://www.readbyqxmd.com/read/28422754/mpeg1-perforin-2-mutations-in-human-pulmonary-nontuberculous-mycobacterial-infections
#17
Ryan M McCormack, Eva P Szymanski, Amy P Hsu, Elena Perez, Kenneth N Olivier, Eva Fisher, E Brook Goodhew, Eckhard R Podack, Steven M Holland
Perforin-2 is a highly conserved pore-forming protein encoded by macrophage expressed gene 1 (MPEG1). A number of studies have shown that Perforin-2-deficient mice are unable to survive following a bacterial challenge that is nonlethal in WT mice. There is also recent evidence that Mpeg1+/- heterozygous mice display an intermediate killing ability compared with Mpeg1 WT and Mpeg1-/- mice. Despite these in vivo findings, to date, no perforin-2 deficiencies have been associated with human disease. Here, we report four patients with persistent nontuberculous mycobacterial infection who had heterozygous MPEG1 mutations...
April 20, 2017: JCI Insight
https://www.readbyqxmd.com/read/28413773/a-m-%C3%A2-avium-complex-spondylodiscitis-in-a-middle-aged-woman-with-diabetes
#18
Irini Gerogianni, Stylianos Boutlas, Theophilos Karachalios, Eythymia Petinaki, Marianna Vlychou, K I Gourgoulianis
Spondylodiscitis, the inflammation of the vertebral bodies and the intervertebral disk space, is the reason for low back pain in a minority of cases. This is caused by various pathogens. Mycobacterium tuberculosis is responsible for 17-39% of all the cases of spondylodiscitis. On the contrast, spondylodiscitis from non tuberculous mycobacteria is extremely rare in literature. We describe a 68 -year old diabetic woman which is the first case of bone marrow involvement by M. intracellulare (member of M avium complex)with spondylodiscitis...
2017: Respiratory Medicine Case Reports
https://www.readbyqxmd.com/read/28377904/mycobacterium-avium-subsp-paratuberculosis-map-fatty-acids-profile-is-strain-dependent-and-changes-upon-host-macrophages-infection
#19
Marta Alonso-Hearn, Naiara Abendaño, Maria A Ruvira, Rosa Aznar, Mariana Landin, Ramon A Juste
Johne's disease is a chronic granulomatous enteritis of ruminants caused by the intracellular bacterium Mycobacterium avium subsp. paratuberculosis (Map). We previously demonstrated that Map isolates from sheep persisted within host macrophages in lower CFUs than cattle isolates after 7 days of infection. In the current study, we hypothesize that these phenotypic differences between Map isolates may be driven be the fatty acids (FAs) present on the phosphadidyl-1-myo-inositol mannosides of the Map cell wall that mediate recognition by the mannose receptors of host macrophages...
2017: Frontiers in Cellular and Infection Microbiology
https://www.readbyqxmd.com/read/28367886/changes-in-serum-iga-antibody-levels-against-the-glycopeptidolipid-core-antigen-during-antibiotic-treatment-of-mycobacterium-avium-complex-lung-disease
#20
Byung Woo Jhun, Su-Young Kim, Hye Yun Park, Kyeongman Jeon, Sung Jae Shin, Won-Jung Koh
We evaluated serial changes in the levels of serum immunoglobulin A (IgA) antibody to the glycopeptidolipid (GPL) core antigen during antibiotic treatment in 57 patients with M. avium complex (MAC) lung disease, at baseline (T0) and after 3 months (T3) and 6 months (T6) of treatment. The median patient age was 59 years and 37 (65%) were female. Etiologic organisms included M. avium in 32 (56%) patients and M. intracellulare in 25 (44%). Seven (12%) patients had the fibrocavitary form of the disease on computed tomography...
March 28, 2017: Japanese Journal of Infectious Diseases
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