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Mycobacterium avium intracellulare

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https://www.readbyqxmd.com/read/29109708/differential-identification-of-mycobacterial-species-using-high-resolution-melting-analysis
#1
Azar D Khosravi, Mohammad Hashemzadeh, Abdolrazagh Hashemi Shahraki, Ali Teimoori
Infections caused by non-tuberculous mycobacteria (NTM) is increasing wordwide. Due to the difference in treatment of NTM infections and tuberculosis, rapid species identification of mycobacterial clinical isolates is necessary for the effective management of mycobacterial diseases treatment and their control strategy. In this study, a cost-effective technique, real-time PCR coupled with high-resolution melting (HRM) analysis, was developed for the differentiation of Mycobacterial species using a novel rpoBC sequence...
2017: Frontiers in Microbiology
https://www.readbyqxmd.com/read/29067283/small-molecule-mediated-restoration-of-mitochondrial-function-augments-anti-mycobacterial-activity-of-human-macrophages-subjected-to-cholesterol-induced-asymptomatic-dyslipidemia
#2
Suman Asalla, Krishnaveni Mohareer, Sharmistha Banerjee
Mycobacterium tuberculosis (M.tb) infection manifests into tuberculosis (TB) in a small fraction of the infected population that comprises the TB susceptible group. Identifying the factors potentiating susceptibility to TB persistence is one of the prime agenda of TB control programs. Recently, WHO recognized diabetes as a risk factor for TB disease progression. The closely related pathological state of metabolic imbalance, dyslipidemia, is yet another emerging risk factor involving deregulation in host immune responses...
2017: Frontiers in Cellular and Infection Microbiology
https://www.readbyqxmd.com/read/29059250/causative-species-of-nontuberculous-mycobacterial-lung-disease-and-comparative-investigation-on-clinical-features-of-mycobacterium-abscessus-complex-disease-a-retrospective-analysis-for-two-major-hospitals-in-a-subtropical-region-of-japan
#3
COMPARATIVE STUDY
Hiroaki Nagano, Takeshi Kinjo, Yuichiro Nei, Shin Yamashiro, Jiro Fujita, Tomoo Kishaba
Nontuberculous mycobacteria (NTM) lung disease is increasing globally. Although the etiological epidemiology of NTM is different across regions, Mycobacterium avium complex (MAC) is the leading cause of NTM lung disease in most countries, including mainland Japan. Okinawa is located in the southernmost region of Japan and is the only prefecture categorized as a subtropical region in Japan, it is therefore likely the etiological epidemiology of NTM lung disease is different from mainland Japan. From 2009 to 2015, the medical records of patients, with respiratory specimens positive for NTMs, visiting or admitted to two Okinawan hospitals, were retrospectively analyzed...
2017: PloS One
https://www.readbyqxmd.com/read/29042494/insights-from-the-genome-sequence-of-mycobacterium-lepraemurium-massive-gene-decay-and-reductive-evolution
#4
Andrej Benjak, Tanvi P Honap, Charlotte Avanzi, Enrique Becerril-Villanueva, Iris Estrada-García, Oscar Rojas-Espinosa, Anne C Stone, Stewart T Cole
Mycobacterium lepraemurium is the causative agent of murine leprosy, a chronic, granulomatous disease similar to human leprosy. Due to the similar clinical manifestations of human and murine leprosy and the difficulty of growing both bacilli axenically, Mycobacterium leprae and M. lepraemurium were once thought to be closely related, although it was later suggested that M. lepraemurium might be related to Mycobacterium avium In this study, the complete genome of M. lepraemurium was sequenced using a combination of PacBio and Illumina sequencing...
October 17, 2017: MBio
https://www.readbyqxmd.com/read/28958380/disseminated-mycobacterium-avium-intracellulare-leading-to-protein-losing-enteropathy-in-an-elderly-man-with-idiopathic-cd4-lymphocytopenia
#5
Carlos J Perez-Lopez, Erving Arroyo, Maristely Rodriguez, Damarys Ortiz, Sylvette Nazario
No abstract text is available yet for this article.
October 2017: Annals of Allergy, Asthma & Immunology
https://www.readbyqxmd.com/read/28947712/evaluation-of-the-association-of-slc11a1-gene-polymorphism-with-incidence-of-paratuberculosis-in-goats
#6
Asha Abraham, Thomas Naicy, Kunniyoor Cheemani Raghavan, Joseph Siju, Thazhathuveettil Aravindakshan
Paratuberculosis is one of the chronic granulomatous enteritis that predominantly affects ruminants world wide, caused by Mycobacterium avium ssp. paratuberculosis (MAP). In ruminants, microsatellite polymorphisms of the 3' untranslated region (3'UTR) of the solute carrier family 11 member A1 (SLC11A1) gene were associated with resistance to intracellular pathogen infections. This research was carried out to detect the polymorphisms in A and B regions of the 3'UTR of SLC11A1 gene and to evaluate the potential association between these polymorphisms and MAP infection in goats...
September 2017: Journal of Genetics
https://www.readbyqxmd.com/read/28943322/contribution-of-intercellular-adhesion-molecule-1-icam-1-to-control-mycobacterium-avium-infection
#7
Rafaella R de Paula, Fábio V Marinho, Julia S Fahel, Sergio C Oliveira
Mycobacterium avium is a facultative intracellular opportunistic pathogen especially relevant in cases of people living with AIDS. The aim of this study was to evaluate the role of intercellular adhesion molecule 1 (ICAM-1) in the inflammatory response against M. avium infection. Mice deficient for ICAM-1 (ICAM KO) and infected with M. avium presented increased bacterial load in the spleen, liver and lungs compared to C57BL/6. Moreover, ICAM deficient mice presented reduced granuloma area in liver at 30 days post-infection with reduced numbers of lymphocytes and granulocytes...
September 22, 2017: Microbes and Infection
https://www.readbyqxmd.com/read/28940325/evaluation-of-the-rt-lamp-and-lamp-methods-for-detection-of-mycobacterium-tuberculosis
#8
Dandan Wu, Jiwen Kang, Baosheng Li, Dianxing Sun
BACKGROUND: The current methods for detecting Mycobacterium tuberculosis (Mtb) are not clinically optimal. Standard culture methods (SCMs) are slow, costly, or unreliable, and loop-mediated isothermal amplification (LAMP) cannot differentiate live Mtb. METHODS: This study compared reverse transcription (RT)-LAMP, LAMP, and an SCM for detecting Mtb. A first experiment tested the sensitivity and specificity of primers for 9 species of Mycobacterium (H37Rv, M. intracellulare, M...
September 22, 2017: Journal of Clinical Laboratory Analysis
https://www.readbyqxmd.com/read/28922813/meta-analyses-and-the-evidence-base-for-microbial-outcomes-in-the-treatment-of-pulmonary-mycobacterium-avium-intracellulare-complex-disease
#9
Jotam G Pasipanodya, Deborah Ogbonna, Devyani Deshpande, Shashikant Srivastava, Tawanda Gumbo
Objectives: To perform a systematic review and meta-analysis of the level of funding support and the sputum culture conversion rates in pulmonary Mycobacterium avium-intracellulare complex (P-MAC) disease in adult patients without cystic fibrosis or HIV infection, treated with recommended antibiotic regimens. Methods: We performed a literature search to identify clinical trials, prospective studies and registries that reported outcomes in P-MAC patients. Studies that reported P-MAC diagnosis and treatments based on established guidelines met the inclusion criteria and were examined for bias and quality...
September 1, 2017: Journal of Antimicrobial Chemotherapy
https://www.readbyqxmd.com/read/28922812/treatment-of-mycobacterium-avium-intracellulare-complex-a-great-leap-forward
#10
Jan-Willem C Alffenaar, Jakko van Ingen
No abstract text is available yet for this article.
September 1, 2017: Journal of Antimicrobial Chemotherapy
https://www.readbyqxmd.com/read/28922810/a-shock-and-awe-thioridazine-and-moxifloxacin-combination-based-regimen-for-pulmonary-mycobacterium-avium-intracellulare-complex-disease
#11
Shashikant Srivastava, Devyani Deshpande, Carleton M Sherman, Tawanda Gumbo
Objectives: To develop a thioridazine/moxifloxacin-based combination regimen for treatment of pulmonary infection due to Mycobacterium avium-intracellulare complex (MAC) that kills bacteria faster than the standard treatment regimen. Methods: Monocytes were infected with MAC and inoculated into the hollow-fibre system model for pulmonary MAC disease (HFS-MAC). We co-administered ethambutol plus azithromycin daily for 28 days, to achieve the same human concentration-time profiles that result from standard doses, in three HFS-MAC systems...
September 1, 2017: Journal of Antimicrobial Chemotherapy
https://www.readbyqxmd.com/read/28922809/a-novel-ceftazidime-avibactam-rifabutin-tedizolid-and-moxifloxacin-cartm-regimen-for-pulmonary-mycobacterium-avium-disease
#12
Devyani Deshpande, Shashikant Srivastava, Jotam G Pasipanodya, Pooi S Lee, Tawanda Gumbo
Objectives: To compare the efficacy of ceftazidime/avibactam plus tedizolid-based combination regimens with the standard therapy of azithromycin, ethambutol and rifabutin for the treatment of pulmonary Mycobacterium avium complex (MAC) disease. Methods: We mimicked the human pulmonary concentration-time profiles of ceftazidime/avibactam and tedizolid in combination, ceftazidime/avibactam, rifabutin, tedizolid and moxifloxacin (CARTM), and the standard regimen and examined microbial kill in triplicate hollow-fibre system model of intracellular pulmonary MAC (HFS-MAC) units...
September 1, 2017: Journal of Antimicrobial Chemotherapy
https://www.readbyqxmd.com/read/28922808/the-discovery-of-ceftazidime-avibactam-as-an-anti-mycobacterium-avium-agent
#13
Devyani Deshpande, Shashikant Srivastava, Moti L Chapagain, Pooi S Lee, Kayle N Cirrincione, Jotam G Pasipanodya, Tawanda Gumbo
Objectives: To determine if ceftaroline and ceftazidime combined with avibactam are efficacious against pulmonary Mycobacterium avium complex (MAC) disease. Methods: First, we performed a concentration-effect study of ceftaroline and ceftaroline/avibactam against extracellular MAC in test tubes. Given the difficulty of obtaining avibactam at the time of experimentation, we used a single concentration of commercial ceftazidime/avibactam, and two sets of non-treated controls, one with ceftazidime/avibactam and the other without...
September 1, 2017: Journal of Antimicrobial Chemotherapy
https://www.readbyqxmd.com/read/28922807/tedizolid-is-highly-bactericidal-in-the-treatment-of-pulmonary-mycobacterium-avium-complex-disease
#14
Devyani Deshpande, Shashikant Srivastava, Jotam G Pasipanodya, Pooi S Lee, Tawanda Gumbo
Objectives: To determine if tedizolid is effective for pulmonary Mycobacterium avium complex (MAC) disease, and to use pharmacokinetics/pharmacodynamics to design optimal doses. Methods: We performed an exposure-response experiment in the hollow-fibre system model of intracellular MAC (HFS-MAC). We mimicked the tedizolid concentration-time profiles achieved in the lungs of patients treated once daily for 28 days. The HFS-MAC was sampled at intervals to determine the tedizolid pharmacokinetics and MAC intracellular burden...
September 1, 2017: Journal of Antimicrobial Chemotherapy
https://www.readbyqxmd.com/read/28920813/mycobacteriosis-in-captive-psittacines-a-brief-review-and-case-series-in-common-companion-species-eclectus-roratus-amazona-oratrix-and-pionites-melanocephala
#15
Anna Elizabeth McRee, Christine T Higbie, Javier G Nevarez, Nathalie T Rademacher, Thomas N Tully
In 2015, three psittacines were presented within 30 days, each with differing clinical signs and patient histories. A 13-yr-old male eclectus parrot (Eclectus roratus) was presented for weakness, depression, and acute anorexia. On presentation it was determined to have a heart murmur, severely elevated white blood cell count (93.9 10(3)/μl) with a left shift (2.8 10(3)/μl bands), and anemia (30%). Severe hepatomegaly was noted on radiographs, ultrasonography, and computed tomography. A cytological sample of the liver obtained through a fine needle aspirate revealed intracellular acid-fast bacilli identified as Mycobacterium avium...
September 2017: Journal of Zoo and Wildlife Medicine: Official Publication of the American Association of Zoo Veterinarians
https://www.readbyqxmd.com/read/28879160/performance-of-xpert-%C3%A2-mtb-rif-among-tuberculosis-outpatients-in-lilongwe-malawi
#16
Tarsizio Chikaonda, Nelson Nguluwe, Brian Barnett, Runa H Gokhale, Robert Krysiak, Isaac Thengolose, Nora E Rosenberg, Christopher Stanley, James Mpunga, Irving F Hoffman, Mina Hosseinipour, Lesley Scott, Wendy Stevens
BACKGROUND: Xpert(®) MTB/RIF is a molecular test for the detection of Mycobacterium tuberculosis and rifampicin resistance. It is considered to be a great advance over smear microscopy and culture. However, there is very little information regarding the performance characteristics of Xpert MTB/RIF in Malawi. OBJECTIVE: We aimed to evaluate the performance of Xpert MTB/RIF in a Malawian setting. METHODS: Stored sputum pellets were processed on Xpert MTB/RIF between June 2012 and May 2014...
2017: African Journal of Laboratory Medicine
https://www.readbyqxmd.com/read/28875176/lactoferricin-peptides-increase-macrophages-capacity-to-kill-mycobacterium-avium
#17
Tânia Silva, Ana C Moreira, Kamran Nazmi, Tânia Moniz, Nuno Vale, Maria Rangel, Paula Gomes, Jan G M Bolscher, Pedro N Rodrigues, Margarida Bastos, Maria Salomé Gomes
Mycobacterial infections cause a significant burden of disease and death worldwide. Their treatment is long, toxic, costly, and increasingly prone to failure due to bacterial resistance to currently available antibiotics. New therapeutic options are thus clearly needed. Antimicrobial peptides represent an important source of new antimicrobial molecules, both for their direct activity and for their immunomodulatory potential. We have previously reported that a short version of the bovine antimicrobial peptide lactoferricin with amino acids 17 to 30 (LFcin17-30), along with its variants obtained by specific amino acid substitutions, killed Mycobacterium avium in broth culture...
July 2017: MSphere
https://www.readbyqxmd.com/read/28855835/distribution-of-non-tuberculosis-mycobacteria-strains-from-suspected-tuberculosis-patients-by-heat-shock-protein-65-pcr-rflp
#18
Ali Nour-Neamatollahie, Nayereh Ebrahimzadeh, Seyed Davar Siadat, Farzam Vaziri, Mona Eslami, Abbas Akhavan Sepahi, Sharareh Khanipour, Morteza Masoumi, Fatemeh Sakhaee, Morteza Ghazanfari Jajin, Ahmadreza Bahrmand, Abolfazl Fateh
The genus Mycobacterium contains more than 150 species. Non-tuberculosis mycobacteria (NTM) often cause extrapulmonary and pulmonary disease. Mycobacteria detection at species level is necessary and provides useful information on epidemiology and facilitates successful treatment of patients. This retrospective study aimed to determine the incidence of the NTM isolates and Mycobacterium tuberculosis (Mtb) in clinical specimens collected from Iranian patients during February 2011-December 2013, by PCR-restriction fragment length polymorphism analysis (PRA) of the hsp65 gene...
September 2017: Saudi Journal of Biological Sciences
https://www.readbyqxmd.com/read/28837070/mechanisms-of-antimicrobial-action-of-cinnamon-and-oregano-oils-cinnamaldehyde-carvacrol-2-5-dihydroxybenzaldehyde-and-2-hydroxy-5-methoxybenzaldehyde-against-mycobacterium-avium-subsp-paratuberculosis-map
#19
Stella W Nowotarska, Krzysztof Nowotarski, Irene R Grant, Christopher T Elliott, Mendel Friedman, Chen Situ
The antimicrobial modes of action of six naturally occurring compounds, cinnamon oil, cinnamaldehyde, oregano oil, carvacrol, 2,5-dihydroxybenzaldehyde, and 2-hydroxy-5-methoxybenzaldehyde, previously found to inhibit the growth of Mycobacterium avium subsp. paratuberculosis (Map) reported to infect food animals and humans and to be present in milk, cheese, and meat, were investigated. The incubation of Map cultures in the presence of all six compounds caused phosphate ions to leak into the extracellular environment in a time- and concentration-dependent manner...
August 24, 2017: Foods (Basel, Switzerland)
https://www.readbyqxmd.com/read/28806745/persistent-mycobacteria-evade-an-antibacterial-program-mediated-by-phagolysosomal-tlr7-8-myd88-in-human-primary-macrophages
#20
Alexandre Gidon, Signe Elisabeth Åsberg, Claire Louet, Liv Ryan, Markus Haug, Trude Helen Flo
Pathogenic mycobacteria reside in macrophages where they avoid lysosomal targeting and degradation through poorly understood mechanisms proposed to involve arrest of phagosomal maturation at an early endosomal stage. A clear understanding of how this relates to host defenses elicited from various intracellular compartments is also missing and can only be studied using techniques allowing single cell and subcellular analyses. Using confocal imaging of human primary macrophages infected with Mycobacterium avium (Mav) we show evidence that Mav phagosomes are not arrested at an early endosomal stage, but mature to a (LAMP1+/LAMP2+/CD63+) late endosomal/phagolysosomal stage where inflammatory signaling and Mav growth restriction is initiated through a mechanism involving Toll-like receptors (TLR) 7 and 8, the adaptor MyD88 and transcription factors NF-κB and IRF-1...
August 2017: PLoS Pathogens
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