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Mycobacterium avium intracellulare

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https://www.readbyqxmd.com/read/29773092/preliminary-study-on-drug-susceptibility-profile-and-resistance-mechanisms-to-macrolides-of-clinical-isolates-of-non-tuberculous-mycobacteria-from-china
#1
Fu Li, Gui Lian Li, Hui Pang, Hai Can Liu, Tong Yang Xiao, Shuang Jun Li, Qiao Luo, Yi Jiang, Rui Bai Wang, Kang Lin Wan
OBJECTIVE: Macrolide susceptibility and drug resistance mechanisms of clinical non-tuberculous mycobacteria (NTM) isolates were preliminarily investigated for more accurate diagnosis and treatment of the infection in China. METHODS: Four macrolides, including clarithromycin (CLAR), azithromycin (AZM), roxithromycin (ROX), and erythromycin (ERY), were used to test the drug susceptibility of 310 clinical NTM isolates from six provinces of China with the broth microdilution method...
April 2018: Biomedical and Environmental Sciences: BES
https://www.readbyqxmd.com/read/29772918/cutaneous-nontuberculous-mycobacterial-infections-in-alberta-canada-an-epidemiologic-study-and-review
#2
Megan A Sander, Judith L Isaac-Renton, Gregory J Tyrrell
BACKGROUND: Cutaneous infections caused by nontuberculous mycobacteria (NTM) occur infrequently. Nonetheless, the incidence of NTM infections is reported to be increasing. In Canada, cutaneous NTM infections have not been well described. OBJECTIVES: A database review from 2006 to 2016 was done to assess species frequency, incidence, and trends of the most common cutaneous NTMs in the province of Alberta, Canada. We also reviewed major diagnostic and epidemiologic aspects of NTM cutaneous infections with a focus on Mycobacterium marinum...
May 1, 2018: Journal of Cutaneous Medicine and Surgery
https://www.readbyqxmd.com/read/29760127/-in-vitro-activity-of-clofazimine-against-non-tuberculous-mycobacteriaisolated-in-beijing-china
#3
Jingjing Luo, Xia Yu, Guanglu Jiang, Yuhong Fu, Fengmin Huo, Yifeng Ma, Fen Wang, Yuanyuan Shang, Qian Liang, Yi Xue, Hairong Huang
Due to the natural resistance of non-tuberculous mycobacteria(NTM) to lots of antibiotics,treatment of diseases caused by NTM is often long-termed but less successful.The main goal of this study was to evaluate the in vitro susceptibility to clofazimine of 209 isolates consisting of different NTM species isolated in Beijing,China. Furthermore,47 reference strains were also tested, including 30 rapidly growing mycobacterium (RGM) species and 17 slowly growing mycobacterium(SGM) species.The potential molecular mechanism contributing to clofazimine resistance of NTM was investigated as well...
May 14, 2018: Antimicrobial Agents and Chemotherapy
https://www.readbyqxmd.com/read/29738438/proctitis-caused-by-mycobacterium-avium-intracellulare-in-an-hiv-infected-patient
#4
Jose Armando Gonzales Zamora, Clara Milikowski
Infectious proctitis is usually associated with sexually transmitted diseases, especially in HIV-infected individuals. Limited information is found about the role of Mycobacterium avium-intracellulare as a causative agent for this condition. Here, we report the case of an HIV-infected patient with a CD4 count of 304 cells/uL and undetectable HIV viral load, who presented with constipation and painful defecation. Endoscopic evaluation was significant for shallow rectal ulcerations. Histopathology revealed poorly formed granulomas...
May 8, 2018: Diseases (Basel)
https://www.readbyqxmd.com/read/29718267/integrated-vaccine-screening-system-using-cellular-functional-capacity-in-vitro-to-assess-genuine-vaccine-protectiveness-in-ruminants
#5
Hannah B Pooley, Karren M Plain, Auriol C Purdie, Douglas J Begg, Richard J Whittington, Kumudika de Silva
Experimental trials in the natural host are essential for development and screening of effective vaccines. For chronic diseases of livestock such as paratuberculosis, these can be lengthy and costly in nature. An alternative is to screen vaccines in vitro; however, previous studies have found that vaccine success in vitro in existing screening assays does not translate to in vivo efficacy. To overcome these issues, we have developed a system that combines both in vivo and in vitro aspects. We hypothesise that the effectiveness of vaccine-induced immune responses mounted in vivo could be gauged by assessing the ability of immune cells to 'control' an in vitro infection...
April 1, 2018: Pathogens and Disease
https://www.readbyqxmd.com/read/29706338/survival-of-mycobacterium-avium-subspecies-paratuberculosis-in-retail-pasteurised-milk
#6
Zara E Gerrard, Benjamin M C Swift, George Botsaris, Ross S Davidson, Michael R Hutchings, Jonathon N Huxley, Catherine E D Rees
A survey of retail purchased semi-skimmed pasteurised milk (n = 368) for Mycobacterium avium subspecies paratuberculosis (MAP) was conducted between May 2014 and June 2015 across the midlands of England using the Phage-PCR assay. Overall, 10.3% of the total samples collected contained viable MAP cells, confirming that pasteurisation is not capable of fully eliminating human exposure to viable MAP through milk. Comparison of the results gained using the Phage-PCR assay with the results of surveys using either culture or direct PCR suggest that the phage-PCR assay is able to detect lower numbers of cells, resulting in an increase in the number of MAP-positive samples detected...
September 2018: Food Microbiology
https://www.readbyqxmd.com/read/29702266/genome-sequence-of-mycobacterium-yongonense-rt-955-2015-isolate-from-a-patient-misdiagnosed-with-multi-drug-resistant-tuberculosis-first-clinical-isolate-in-tanzania
#7
Nicholaus Peter Mnyambwa, Dong-Jin Kim, Esther Ngadaya, Jongsik Chun, Sung-Min Ha, Pammla Petrucka, Kennedy Kwasi Addo, Rudovick R Kazwala, Sayoki G Mfinanga
BACKGROUND: Mycobacterium yongonense is a recently described novel species belonging to Mycobacterium avium complex which is the most prevalent etiology of non-tuberculous mycobacteria associated with pulmonary infections, and posing tuberculosis diagnostic challenges in high-burden, resource-constrained settings. METHODS: We used whole genome shotgun sequencing and comparative microbial genomic analyses to characterize the isolate from a patient diagnosed with multi-drug resistant tuberculosis (MDR-TB) after relapse...
April 24, 2018: International Journal of Infectious Diseases: IJID
https://www.readbyqxmd.com/read/29701251/determination-of-antibiotic-resistance-and-high-performance-liquid-chromatography-profiles-for-mycobacterium-species
#8
Türkan Toka Özer, Erkan Yula, Metin Doğan, Hüseyin Baskın
BACKGROUND: Incidence of mycobacterial infections has been increasing. However, diagnosis and treatment of mycobacterial infections can be difficult. The aim of this study was to investigate high-performance liquid chromatography (HPLC) analysis of the mycolic acids for rapid identification and dendrogram cluster analysis of mycobacterium species. METHODS: Clinical specimens received for mycobacterial culture and antimicrobial susceptibility test were processed by standard laboratory protocols...
April 27, 2018: Journal of Clinical Laboratory Analysis
https://www.readbyqxmd.com/read/29683417/whole-genome-sequence-analysis-of-the-mycobacterium-avium-complex-and-proposal-of-the-transfer-of-mycobacterium-yongonense-to-mycobacterium-intracellulare-subsp-yongonense-subsp-nov
#9
Maria Castejon, Maria Carmen Menéndez, Iñaki Comas, Ana Vicente, Maria J Garcia
Bacterial whole-genome sequences contain informative features of their evolutionary pathways. Comparison of whole-genome sequences have become the method of choice for classification of prokaryotes, thus allowing the identification of bacteria from an evolutionary perspective, and providing data to resolve some current controversies. Currently, controversy exists about the assignment of members of the Mycobacterium avium complex, as is for the cases of Mycobacterium yongonense and 'Mycobacterium indicus pranii'...
April 23, 2018: International Journal of Systematic and Evolutionary Microbiology
https://www.readbyqxmd.com/read/29622826/hot-tub-lung-an-intriguing-diffuse-parenchymal-lung-disease
#10
Mohan Rudrappa, Laxmi Kokatnur
In pulmonary medicine, identical pathogenesis due to varied etiological agents can present with indistinguishable clinical presentation, and produce similar laboratory and radiological changes. The importance of eliciting detailed occupational and social history from patients cannot be stressed enough when dealing with patients suffering from diffuse parenchymal lung diseases. Hot Tub Lung(HTL) is a perplexing pulmonary disease attributed to the Mycobacterium Avium-intracellulare Complex (MAC). MAC is a ubiquitous atypical mycobacterium present in moist environment, and is not considered pathogenic, without the predisposing conditions like immunosuppression...
September 2017: Ghana Medical Journal
https://www.readbyqxmd.com/read/29607168/the-outcomes-of-anatomical-lung-resection-for-nontuberculous-mycobacterial-lung-disease
#11
Tadashi Sakane, Katsunari Matsuoka, Sakiko Kumata, Risa Watanabe, Tetsu Yamada, Takahisa Matsuoka, Shinjiro Nagai, Mitsuhiro Ueda, Yoshihiro Miyamoto
Background: The number of cases of nontuberculous mycobacterial (NTM) lung disease has been increasing in recent years, and the efficacy of surgical treatment has been recognized. We investigated the clinical characteristics and behavior of NTM lung disease and analyzed the outcomes of surgery. Methods: The data of 25 patients who underwent anatomical resection for NTM lung disease in our institution between January 2004 and December 2014 were retrospectively examined...
February 2018: Journal of Thoracic Disease
https://www.readbyqxmd.com/read/29604199/antimycobacterial-potential-of-the-juniper-berry-essential-oil-in-tap-water
#12
Dolores Peruč, Ivana Gobin, Maja Abram, Dalibor Broznić, Tomislav Svalina, Sanja Štifter, Mladenka Malenica Staver, Brigita Tićac
Mycobacterium avium complex-related diseases are often associated with poorly maintained hot water systems. This calls for the development of new control strategies. The aim of this study was to investigate the activity of essential oils (EOs) from the Mediterranean plants, common juniper, immortelle, sage, lavandin, laurel, and white cedar against Mycobacterium avium ssp. avium, Mycobacterium intracellulare, and Mycobacterium gordonae in culturing broth and freshwater as their most common habitat. To do that, we developed a new method of water microdilution to determine their minimal effective concentrations (MEC)...
March 1, 2018: Arhiv za Higijenu Rada i Toksikologiju
https://www.readbyqxmd.com/read/29570591/the-emergence-of-non-tuberculous-mycobacterial-lymphadenitis-in-children-after-the-discontinuation-of-mandatory-bcg-immunization-in-france
#13
Adèle Lacroix, Caroline Piau, Philippe Lanotte, Anne Carricajo, Aurelie Guillouzouic, Olivia Peuchant, Anne Cady, Clarisse Dupin, Marie-Sarah Fangous, Christian Martin, Marie-Estelle Cariou, Florence Le Gall, Pascale Bemer, Pierre Tattevin
Eighty-five children were diagnosed with culture-confirmed non-tuberculous mycobacterial cervical lymphadenitis within the MYCOMED surveillance network in 2004-2013. The mean incidence sharply increased from 0.57 to 3.7 per 100,000 children/year, following discontinuation of mandatory BCG immunization in 2007. Cases were due to Mycobacterium avium (62.3%), M. intracellulare (15.3%), and M. lentiflavum(12.9%). Outcome was favorable in all, with or without surgery or antimycobacterial treatment.
March 21, 2018: Pediatric Infectious Disease Journal
https://www.readbyqxmd.com/read/29567906/nontuberculous-mycobacterial-empyema-in-an-immunocompetent-child
#14
Ira Shah, Forum Shah
Nontuberculous mycobacterium (NTM) species are mycobacterial species other than those belonging to the Mycobacterium Tuberculosis complex and Mycobacterium leprae. There are very few reports of NTM in immunocompetent children causing empyema. In this article, we report a 9-year-old immunocompetent girl who presented with Mycobacterium avium-intracellulare empyema.
January 2018: Indian Journal of Pathology & Microbiology
https://www.readbyqxmd.com/read/29546549/identification-of-mycobacterium-species-and-rhodococcus-equi-in-peccary-lymph-nodes
#15
Amanda Bonalume Cordeiro de Morais, Carmen Alicia Daza Bolaños, Ana Carolina Alves, Cássia Yumi Ikuta, Gustavo Henrique Batista Lara, Marcos Bryan Heinemann, Rogério Giuffrida, Fernando Paganini Listoni, Mateus de Souza Ribeiro Mioni, Rodrigo Garcia Motta, Shinji Takai, Márcio Garcia Ribeiro
Mycobacterium species and the virulence-associated proteins (vapA, vapB, and vapN genes) of Rhodococcus equi isolated from 330 lymph nodes of collared peccaries (Tayassu tajacu) and white-lipped peccaries (Tayassu pecari) intended for human consumption were investigated. Thirty-six (10.9%) R. equi strains were isolated; 3.3% (n = 11/330) were from white-lipped peccary lymph nodes, and 7.6% (25/330) were from collared peccary lymph nodes. Among the 11 isolates of R. equi from the white-lipped peccaries, 90...
March 15, 2018: Tropical Animal Health and Production
https://www.readbyqxmd.com/read/29516886/virulence-of-mycobacterium-avium-subsp-hominissuis-human-isolates-in-an-in-vitro-macrophage-infection-model
#16
Laura Rindi, Nicoletta Lari, Carlo Garzelli
Background: Mycobacterium avium subsp. hominissuis (MAH) is an environmental opportunistic pathogen for humans and swine worldwide; in humans, the vast majority of MAH infections is due to strains belonging to specific genotypes, such as the internal transcribed spacer (ITS)-sequevars Mav-A and Mav-B that mostly cause pulmonary infections in elderly patients and severe disseminated infections in acquired immunodeficiency syndrome patients, respectively. To test whether the different types of infections in distinct patients' populations might reflect a different virulence of the infecting genotypes, MAH human isolates, genotyped by ITS sequencing and MIRU-VNTR minisatellite analysis, were studied for the capacity to infect and replicate in human macrophages in vitro...
January 2018: International Journal of Mycobacteriology
https://www.readbyqxmd.com/read/29483164/the-many-lives-of-nontuberculous-mycobacteria
#17
Tiffany A Claeys, Richard T Robinson
Nontuberculous mycobacteria (NTM) include species that colonize human epithelia, as well as species that are ubiquitous in soil and aquatic environments. NTM that primarily inhabit soil and aquatic environments include the Mycobacterium avium complex (MAC, M. avium and Mycobacterium intracellulare ) and the Mycobacterium abscessus complex (MABSC, M. abscessus subspecies abscessus , massiliense , and bolletii ), and can be free-living, biofilm-associated, or amoeba-associated. Although NTM are rarely pathogenic in immunocompetent individuals, those who are immunocompromised - due to either an inherited or acquired immunodeficiency - are highly susceptible to NTM infection (NTMI)...
February 26, 2018: Journal of Bacteriology
https://www.readbyqxmd.com/read/29458660/identification-of-antigenic-proteins-from-mycobacterium-avium-subspecies-paratuberculosis-cell-envelope-by-comparative-proteomic-analysis
#18
Shanmugasundaram Karuppusamy, Lucy Mutharia, David Kelton, Niel Karrow, Gordon Kirby
Johne's disease (JD) is a contagious, chronic granulomatous enteritis of ruminants caused by Mycobacterium avium subsp. paratuberculosis (MAP). The aim of this study was to identify antigenic proteins from the MAP cell envelope (i.e. cell wall and cytoplasmic membranes) by comparing MAP, M. avium subsp. hominissuis (MAH) and M. smegmatis (MS) cell envelope protein profiles using a proteomic approach. Composite two-dimensional (2D) difference gel electrophoresis images revealed 13 spots present only in the image of the MAP cell envelope proteins...
March 2018: Microbiology
https://www.readbyqxmd.com/read/29441757/changing-epidemiology-of-nontuberculous-mycobacterial-lung-diseases-in-a-tertiary-referral-hospital-in-korea-between-2001-and-2015
#19
Ryoung Eun Ko, Seong Mi Moon, Soohyun Ahn, Byung Woo Jhun, Kyeongman Jeon, O Jung Kwon, Hee Jae Huh, Chang Seok Ki, Nam Yong Lee, Won Jung Koh
This study investigated the changes in the major etiologic organisms and clinical phenotypes of nontuberculous mycobacterial lung disease (NTM-LD) over a recent 15-year period in Korea. The increase of number of patients with NTM-LD was primarily due to an increase of Mycobacterium avium complex (MAC) lung disease (LD). Among MAC cases, the proportion of M. avium increased compared with M. intracellulare, whereas the incidence of M. abscessus complex and M. kansasii LD remained relatively stable. The proportion of cases of the nodular bronchiectatic form increased compared with the fibrocavitary form of NTM-LD...
February 19, 2018: Journal of Korean Medical Science
https://www.readbyqxmd.com/read/29325687/clinical-significance-and-epidemiologic-analyses-of-mycobacterium-avium-and-mycobacterium-intracellulare-lung-disease-from-post-marketing-surveillance
#20
Katsuhiro Suzuki, Atsuyuki Kurashima, Kinji Tatsuno, Jun-Ichi Kadota
BACKGROUND: In Japan, nontuberculous mycobacterial lung disease is mostly attributable to Mycobacterium avium complex (MAC), i.e., M. avium or M. intracellulare. However, clinical features of the disease caused by these two pathogens have not been studied sufficiently yet. METHODS: A post-marketing survey of clarithromycin was performed at 130 facilities across Japan. The data on patients with M. avium infection and patients with M. intracellulare infection were selected from this survey for comparison of background variables and clinical features of the two pathogens...
January 2018: Respiratory Investigation
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