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Mycobacterium avium intracellulare

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https://www.readbyqxmd.com/read/28424429/the-volatile-molecule-signature-of-four-mycobacteria-species
#1
Theodore Mellors, Christiaan Rees, Wendy Wieland-Alter, C Fordham von Reyn, Jane E Hill
Mycobacteria are the leading cause of death from infectious disease worldwide and limitations in current diagnostics are hampering control efforts. In recent years, the use of small volatile molecules as diagnostic biomarkers for mycobacteria has shown promise for use in the rapid analysis of in vitro cultures as well as ex vivo diagnosis using breath or sputum. In this study, 18 strains from four mycobacteria species (Mycobacterium avium, M. bovis BCG, M. intracellulare and M. xenopi) were analyzed for the first time using two-dimensional gas chromatography time-of-flight mass spectrometry (GC×GC-TOFMS)...
April 20, 2017: Journal of Breath Research
https://www.readbyqxmd.com/read/28422754/mpeg1-perforin-2-mutations-in-human-pulmonary-nontuberculous-mycobacterial-infections
#2
Ryan M McCormack, Eva P Szymanski, Amy P Hsu, Elena Perez, Kenneth N Olivier, Eva Fisher, E Brook Goodhew, Eckhard R Podack, Steven M Holland
Perforin-2 is a highly conserved pore-forming protein encoded by macrophage expressed gene 1 (MPEG1). A number of studies have shown that Perforin-2-deficient mice are unable to survive following a bacterial challenge that is nonlethal in WT mice. There is also recent evidence that Mpeg1+/- heterozygous mice display an intermediate killing ability compared with Mpeg1 WT and Mpeg1-/- mice. Despite these in vivo findings, to date, no perforin-2 deficiencies have been associated with human disease. Here, we report four patients with persistent nontuberculous mycobacterial infection who had heterozygous MPEG1 mutations...
April 20, 2017: JCI Insight
https://www.readbyqxmd.com/read/28413773/a-m-%C3%A2-avium-complex-spondylodiscitis-in-a-middle-aged-woman-with-diabetes
#3
Irini Gerogianni, Stylianos Boutlas, Theophilos Karachalios, Eythymia Petinaki, Marianna Vlychou, K I Gourgoulianis
Spondylodiscitis, the inflammation of the vertebral bodies and the intervertebral disk space, is the reason for low back pain in a minority of cases. This is caused by various pathogens. Mycobacterium tuberculosis is responsible for 17-39% of all the cases of spondylodiscitis. On the contrast, spondylodiscitis from non tuberculous mycobacteria is extremely rare in literature. We describe a 68 -year old diabetic woman which is the first case of bone marrow involvement by M. intracellulare (member of M avium complex)with spondylodiscitis...
2017: Respiratory Medicine Case Reports
https://www.readbyqxmd.com/read/28377904/mycobacterium-avium-subsp-paratuberculosis-map-fatty-acids-profile-is-strain-dependent-and-changes-upon-host-macrophages-infection
#4
Marta Alonso-Hearn, Naiara Abendaño, Maria A Ruvira, Rosa Aznar, Mariana Landin, Ramon A Juste
Johne's disease is a chronic granulomatous enteritis of ruminants caused by the intracellular bacterium Mycobacterium avium subsp. paratuberculosis (Map). We previously demonstrated that Map isolates from sheep persisted within host macrophages in lower CFUs than cattle isolates after 7 days of infection. In the current study, we hypothesize that these phenotypic differences between Map isolates may be driven be the fatty acids (FAs) present on the phosphadidyl-1-myo-inositol mannosides of the Map cell wall that mediate recognition by the mannose receptors of host macrophages...
2017: Frontiers in Cellular and Infection Microbiology
https://www.readbyqxmd.com/read/28367886/changes-in-serum-iga-antibody-levels-against-the-glycopeptidolipid-core-antigen-during-antibiotic-treatment-of-mycobacterium-avium-complex-lung-disease
#5
Byung Woo Jhun, Su-Young Kim, Hye Yun Park, Kyeongman Jeon, Sung Jae Shin, Won-Jung Koh
We evaluated serial changes in the levels of serum immunoglobulin A (IgA) antibody to the glycopeptidolipid (GPL) core antigen during antibiotic treatment in 57 patients with M. avium complex (MAC) lung disease, at baseline (T0) and after 3 months (T3) and 6 months (T6) of treatment. The median patient age was 59 years and 37 (65%) were female. Etiologic organisms included M. avium in 32 (56%) patients and M. intracellulare in 25 (44%). Seven (12%) patients had the fibrocavitary form of the disease on computed tomography...
March 28, 2017: Japanese Journal of Infectious Diseases
https://www.readbyqxmd.com/read/28356415/evaluation-of-the-genotype-ntm-dr-assay-for-identification-of-mycobacterium-chimaera
#6
Simone Mok, Thomas R Rogers, Margaret Fitzgibbon
Identification of species within the Mycobacterium avium Complex (MAC) is difficult and most current diagnostic laboratory tests cannot distinguish between species included in the complex. Differentiation of species within the MAC is important as Mycobacterium chimaera has recently emerged as major cause of invasive cardiovascular infections following open heart surgery. A new commercial diagnostic assay, GenoType NTM-DR ver. 1.0, is intended to differentiate between three species within the MAC, namely Mycobacterium avium, Mycobacterium intracellulare and Mycobacterium chimaera In this study we investigated an archival collection of 173 MAC isolates using 16S rRNA and 16S-23S ITS gene sequencing, and the GenoType NTM-DR was evaluated for identifying M...
March 29, 2017: Journal of Clinical Microbiology
https://www.readbyqxmd.com/read/28337084/therapeutic-drug-monitoring-of-continuous-infusion-doripenem-in-a-pediatric-patient-on-continuous-renal-replacement-therapy
#7
Jeffrey J Cies, Wayne S Moore, Susan B Conley, Paul Shea, Adela Enache, Arun Chopra
An 11-year-old African American male with severe combined immunodeficiency variant, non-cystic fibrosis bronchiectasis, pancreatic insufficiency, chronic mycobacterium avium-intracellulare infection, chronic sinusitis, and malnutrition presented with a 1-week history of fevers. He subsequently developed respiratory decompensation and cefepime was discontinued and doripenem was initiated. Doripenem was the carbapenem used due to a national shortage of meropenem. By day 7 the patient (24.7 kg) had a positive fluid balance of 6925 mL (28% FO), and on days 7 into 8 developed acute kidney injury evidenced by an elevated serum creatinine of 0...
January 2017: Journal of Pediatric Pharmacology and Therapeutics: JPPT: the Official Journal of PPAG
https://www.readbyqxmd.com/read/28333340/evaluation-of-the-new-genotype-ntm-dr-kit-for-the-molecular-detection-of-antimicrobial-resistance-in-non-tuberculous-mycobacteria
#8
Faiza Mougari, Jade Loiseau, Nicolas Veziris, Christine Bernard, Béatrice Bercot, Wladimir Sougakoff, Vincent Jarlier, Laurent Raskine, Emmanuelle Cambau
Objectives: Non-tuberculous mycobacteria (NTM) are emerging pathogens causing difficult-to-treat infections. We tested a new assay (GenoType NTM-DR) that detects natural and acquired resistance mechanisms to macrolides and aminoglycosides in frequently isolated NTM species. Methods: Performance was assessed on 102 isolates including reference strains [16 Mycobacterium avium , 10 Mycobacterium intracellulare , 8 Mycobacterium chimaera , 15 Mycobacterium chelonae and 53 Mycobacterium abscessus (including subsp...
February 28, 2017: Journal of Antimicrobial Chemotherapy
https://www.readbyqxmd.com/read/28330892/in-vitro-susceptibility-testing-of-tedizolid-against-nontuberculous-mycobacteria
#9
Barbara A Brown-Elliott, Richard J Wallace
Tedizolid is a new oxazolidinone with improved in vitro and intracellular potency against Mycobacterium tuberculosis, including multidrug resistant strains, and some species of nontuberculous mycobacteria (NTM) compared with linezolid.Using the current Clinical and Laboratory Standards Institute (CLSI) recommended method of broth microdilution, susceptibility testing of 170 isolates of rapidly growing mycobacteria showed equivalent or lower (1- to 8-fold MIC50 and/or MIC90 values) for tedizolid compared to linezolid...
March 22, 2017: Journal of Clinical Microbiology
https://www.readbyqxmd.com/read/28317808/isolation-and-characterization-of-nontuberculous-mycobacteria-from-patients-with-pulmonary-tuberculosis-in-ghana
#10
Isaac Darko Otchere, Adwoa Asante-Poku, Stephen Osei-Wusu, Samuel Yaw Aboagye, Dorothy Yeboah-Manu
OBJECTIVE/BACKGROUND: Nontuberculous mycobacterial (NTM) species are assuming public health importance in pulmonary diseases; they are increasingly being isolated, and importantly, most NTMs do not respond to routine tuberculosis (TB) drugs. This study aimed to identify NTMs isolated from pulmonary TB cases and also determine their susceptibility to streptomycin (STR), isoniazid (INH), and rifampicin (RIF). METHODS: A total of 1755 mycobacterial isolates, obtained between August 2012 and July 2014, from 2036 smear-positive pulmonary cases were identified using polymerase chain reaction amplification of IS6110, and hsp65 gene sequencing analysis...
January 2017: International Journal of Mycobacteriology
https://www.readbyqxmd.com/read/28297817/-distribution-and-drug-resistance-of-nontuberculous-mycobacteria-in-beijing
#11
J Zhang, J R Su, B C Ding, J W Liu, J L Yi, X Y Yang, N H Wang, S M Wang
Objective: To analyze the distribution and drug resistance of nontuberculous mycobacteria(NTM) in Beijing. Methods: Using PCR-fluorescence probe method we identified 1 552 mycobacterial isolates in 2009 and 1 553 mycobacterial isolates in 2013, which were stored by Beijing Research Institute for Tuberculosis Control.All identified NTM strains were confirmed by 16S rRNA gene sequencing, and drug sensitivity testing was performed by using 1% ratio method.SPSS 13.0 was used for statistical analysis. Results: The isolation rate for NTM in 2009 and 2013 was 3...
March 12, 2017: Chinese Journal of Tuberculosis and Respiratory Diseases
https://www.readbyqxmd.com/read/28291631/distribution-and-clinical-significance-of-mycobacterium-avium-complex-species-isolated-from-respiratory-specimens
#12
Su-Young Kim, Sun Hye Shin, Seong Mi Moon, Bumhee Yang, Hojoong Kim, O Jung Kwon, Hee Jae Huh, Chang-Seok Ki, Nam Yong Lee, Sung Jae Shin, Won-Jung Koh
Mycobacterium avium complex (MAC) was originally composed of 2 species, M. avium and M. intracellulare. However, several new species closely related to M. intracellulare have recently been identified. In addition, M. avium has been further subdivided into 4 subspecies. The aim of this study was to determine the proportion of different MAC species recovered from respiratory specimens and to elucidate the clinical relevance of these species. Clinical isolates, from 219 patients, that had been initially identified as M...
March 2, 2017: Diagnostic Microbiology and Infectious Disease
https://www.readbyqxmd.com/read/28280641/prosthetic-joint-infection-due-to-mycobacterium-avium-intracellulare-in-a-patient-with-rheumatoid-arthritis-a-case-report-and-review-of-the-literature
#13
Nicholas E Ingraham, Brenton Schneider, Jonathan D Alpern
Nontuberculous mycobacteria (NTM) are a rare cause of prosthetic joint infections (PJI). However, the prevalence of NTM infections may be increasing with the rise of newer immunosuppressive medications such as biologics. In this case report, we describe a rare complication of immunosuppressive therapies and highlight the complexity of diagnosing and treating PJI due to NTM. The patient is a 79-year-old Caucasian male with a history of severe destructive rheumatoid arthritis on several immunosuppressive agents and right hip osteoarthritis s/p total hip arthroplasty 15 years previously with several complex revisions, presenting with several weeks of worsening right hip and abdominal pain...
2017: Case Reports in Infectious Diseases
https://www.readbyqxmd.com/read/28265761/risk-factors-of-non-tuberculous-mycobacterial-lymphadenitis-in-children-a-case-control-study
#14
Patricia W Garcia-Marcos, Mercedes Plaza-Fornieles, Ana Menasalvas-Ruiz, Ramon Ruiz-Pruneda, Pedro Paredes-Reyes, Santiago Alfayate Miguelez
The aim of the present study is to clarify the association between environmental exposures and non-tuberculous mycobacterial (NTM) lymphadenitis, during the last decade, in a population of children. In children up to 14 years of age in a pediatric tertiary hospital, all cases of NTM lymphadenopathy with a specific microbiological diagnosis, from January 2004 to January 2015, were reviewed. This is a case-control study (1:5 proportion), in which the prevalence of environmental factors between cases and controls was compared by means of a multivariate logistic regression analysis...
March 6, 2017: European Journal of Pediatrics
https://www.readbyqxmd.com/read/28242674/in-vitro-activity-of-bedaquiline-against-nontuberculous-mycobacteria-in-china
#15
Yu Pang, Huiwen Zheng, Yaoju Tan, Yuanyuan Song, Yanlin Zhao
The main goal of our study was to evaluate in vitro drug susceptibility of bedaquiline against six prevalent pathogenic nontuberculous mycobacteria (NTM) diseases in China. In addition, we investigated the potential molecular mechanism contributing to the bedaquiline resistance in these different NTM species. For slowly growing mycobacteria (SGM), bedaquiline exhibited the highest activity against Mycobacterium avium, the MIC50 and MIC90 were 0.03 and 16 mg/L, respectively. Of rapidly growing mycobacteria (RGM), Mycobacterium abscessus subsp...
February 27, 2017: Antimicrobial Agents and Chemotherapy
https://www.readbyqxmd.com/read/28040888/seasonal-assessment-of-opportunistic-premise-plumbing-pathogens-in-roof-harvested-rainwater-tanks
#16
Kerry A Hamilton, Warish Ahmed, Andrew Palmer, Kylie Smith, Simon Toze, Charles N Haas
A seasonal study on the occurrence of six opportunistic premise plumbing pathogens (OPPPs) in 24 roof-harvested rainwater (RHRW) tanks repeatedly sampled over six monthly sampling events (n = 144) from August 2015 to March 2016 was conducted using quantitative qPCR. Fecal indicator bacteria (FIB) Escherichia coli (E. coli) and Enterococcus spp. were enumerated using culture-based methods. All tank water samples over the six events were positive for at least one OPPP (Legionella spp., Legionella pneumophila, Mycobacterium avium, Mycobacterium intracellulare, Pseudmonas aeruginosa, or Acanthamoeba spp...
January 26, 2017: Environmental Science & Technology
https://www.readbyqxmd.com/read/27959960/nontuberculous-mycobacterial-infections-in-a-french-hospital-a-12-year-retrospective-study
#17
Peggy Blanc, Hervé Dutronc, Olivia Peuchant, Frédéric-Antoine Dauchy, Charles Cazanave, Didier Neau, Gaëtane Wirth, Jean-Luc Pellegrin, Philippe Morlat, Patrick Mercié, José-Manuel Tunon-de-Lara, Marie-Sylvie Doutre, Philippe Pélissier, Michel Dupon
BACKGROUND: Nontuberculous mycobacteria (NTM) are environmental organisms associated with a range of infections. Reports of NTM epidemiology are mainly focused on pulmonary infections and isolations, and extrapulmonary infections are less frequently described. METHODS: We conducted a retrospective study of NTM infections at the Bordeaux University Hospital, France, between January 2002 and December 2013. We used the microbiologic component of the American Thoracic Society/Infectious Diseases Society of America's pulmonary NTM disease criteria to define cases of pulmonary NTM, and patients with isolates from a normally sterile site were classified as having extrapulmonary disease...
2016: PloS One
https://www.readbyqxmd.com/read/27918379/nontuberculous-mycobacteria-in-children-a-focus-on-bloodstream-infections
#18
Laila S Al Yazidi, Ben J Marais, Briony Hazelton, Alexander Outhred, Alison Kesson
BACKGROUND: Nontuberculous mycobacteria (NTM) are ubiquitous organisms with variable disease-causing potential. Bloodstream infections caused by NTM in children are poorly described. METHODS: We describe a retrospective case series of children with culture-confirmed mycobacterial disease managed at the Children's Hospital at Westmead between July 2005 and June 2015. RESULTS: Sixty-five patients had 149 positive NTM cultures; 55 (83.0%) episodes in 54 patients were considered clinically significant...
April 2017: Pediatric Infectious Disease Journal
https://www.readbyqxmd.com/read/27915187/dose-response-models-and-a-quantitative-microbial-risk-assessment-framework-for-the-mycobacterium-avium-complex-that-account-for-recent-developments-in-molecular-biology-taxonomy-and-epidemiology
#19
REVIEW
Kerry A Hamilton, Mark H Weir, Charles N Haas
Mycobacterium avium complex (MAC) is a group of environmentally-transmitted pathogens of great public health importance. This group is known to be harbored, amplified, and selected for more human-virulent characteristics by amoeba species in aquatic biofilms. However, a quantitative microbial risk assessment (QMRA) has not been performed due to the lack of dose response models resulting from significant heterogeneity within even a single species or subspecies of MAC, as well as the range of human susceptibilities to mycobacterial disease...
February 1, 2017: Water Research
https://www.readbyqxmd.com/read/27911922/nucleic-acid-amplification-testing-and-sequencing-combined-with-acid-fast-staining-in-needle-biopsy-lung-tissues-for-the-diagnosis-of-smear-negative-pulmonary-tuberculosis
#20
Faming Jiang, Weiwei Huang, Ye Wang, Panwen Tian, Xuerong Chen, Zongan Liang
BACKGROUND: Smear-negative pulmonary tuberculosis (PTB) is common and difficult to diagnose. In this study, we investigated the diagnostic value of nucleic acid amplification testing and sequencing combined with acid-fast bacteria (AFB) staining of needle biopsy lung tissues for patients with suspected smear-negative PTB. METHODS: Patients with suspected smear-negative PTB who underwent percutaneous transthoracic needle biopsy between May 1, 2012, and June 30, 2015, were enrolled in this retrospective study...
2016: PloS One
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